Multi-stage crushing device for valaciclovir hydrochloride production

Abstract

The utility model belongs to the technical field of valaciclovir production equipment, and particularly relates to a multi-stage crushing device for valaciclovir hydrochloride production, which comprises a box body, a barrel body fixedly mounted at the top of the box body, a first motor fixedly mounted at the top of the barrel body, a feeding hole formed in the side edge, corresponding to the first motor, of the top of the barrel body, and a guide hopper fixedly mounted in the box body, according to the valaciclovir raw material crushing device, valaciclovir raw materials are added into the barrel through the feeding port, at the moment, the first motor rotates, the crushing blades are driven to rotate through the rotating shaft, and therefore the valaciclovir raw materials are crushed; and the crushed raw materials fall between two groups of crushing rollers through a guide hopper, meanwhile, a second motor is started, the crushing rollers are driven to rotate through a rotating rod, the crushed raw materials are subjected to secondary crushing, and the phenomenon of incomplete crushing is prevented.

Description

Technical Field

[0001] This utility model relates to the technical field of valacyclovir production equipment, specifically a multi-stage pulverizing device for the production of valacyclovir hydrochloride. Background Technology

[0002] Valacyclovir hydrochloride is the hydrochloride salt of valacyclovir, which is a precursor of acyclovir-L-valine ester. Acyclovir is a synthetic purine nucleoside analog, chemically named 9-(2-hydroxyethoxymethyl)guanine (CAS No. 59277-89-3). It appears as a white to pale yellow crystalline powder and is widely used clinically worldwide as a treatment for herpes, shingles, and other skin conditions.

[0003] The existing technology has the following shortcomings; the existing technology, disclosed in CN211937090U, "A multi-stage pulverizing device for the production of valacyclovir hydrochloride", "includes a hollow cylindrical box with a feed inlet on the upper surface of the box; a conical baffle is provided inside the box; the internal area of ​​the box above the baffle is a pulverizing chamber, and the internal area of ​​the box below the baffle is a collecting chamber; a primary pulverizing device is connected to the upper surface of the pulverizing chamber, and a secondary pulverizing device is provided below the primary pulverizing device; a collecting tray is provided on the lower surface of the collecting chamber, and a handle is connected to one side of the collecting tray; an independent heating chamber is also provided above the pulverizing chamber, and the heating chamber is connected to the collecting chamber at the bottom through a heat-conducting pipe";

[0004] The aforementioned equipment uses two types of crushing devices—a rotary crushing roller and a compression crushing device—to perform multi-stage crushing of the added valacyclovir intermediate. This solves the shortcomings of existing technologies, such as poor crushing effect and incomplete crushing. It features good crushing effect, one-time crushing, no need for refeeding, and high efficiency. However, it can only crush valacyclovir to one specification at a time. When it is necessary to crush valacyclovir to different specifications, multiple crushing devices of different specifications are required, which is inconvenient for crushing valacyclovir to multiple specifications as needed. Utility Model Content

[0005] To address the shortcomings of existing technologies, this invention provides a multi-stage pulverizing device for the production of valacyclovir hydrochloride, thereby solving the problems mentioned in the background section.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a multi-stage pulverizing device for the production of valacyclovir hydrochloride, comprising a housing, a cylinder fixedly installed on the top of the housing, a first motor fixedly installed on the top of the cylinder, a feed inlet on the side of the top of the cylinder corresponding to the first motor, a guide hopper fixedly installed inside the housing, two sets of support plates fixedly installed inside the housing below the guide hopper, and a pulverizing roller provided between the two sets of support plates.

[0007] As a preferred embodiment of this utility model, a rotating shaft is fixedly installed at the output end of the first motor, and a crushing blade is fixedly installed on the outer surface of the rotating shaft, extending to the bottom of the cylinder.

[0008] As a preferred technical solution of this utility model, the support plate has a through hole, and two sets of sliding plates are slidably installed inside the through hole. A second motor is fixedly installed on the outside of one set of sliding plates, and a rotating rod is rotatably installed between each pair of corresponding sliding plates. The crushing roller is fixedly installed on the rotating rod.

[0009] As a preferred embodiment of this utility model, one end of one set of rotating rods is fixedly connected to the second motor, and the other ends of both sets of rotating rods extend to the outside of the slide plate and are fixedly installed with a first gear. The two sets of first gears are respectively hinged to install a second gear and a third gear.

[0010] As a preferred embodiment of this utility model, a first connecting rod is rotatably mounted between one set of the first gear, the second gear, and the third gear, and a second connecting rod is rotatably mounted between the other set of the first gear and the second gear, with the second gear and the third gear meshing together.

[0011] As a preferred embodiment of this utility model, two sets of symmetrically arranged hydraulic rods are fixedly installed inside the box body on the side corresponding to the support plate, and the telescopic ends of the two sets of hydraulic rods are respectively rotatably connected to the rotating rod.

[0012] As a preferred embodiment of this utility model, a collection frame is slidably installed inside the box corresponding to the bottom of the crushing roller, and one end of the collection frame extends to the outside of the box and is fixedly installed with a handle.

[0013] Compared with the prior art, this utility model provides a multi-stage pulverizing device for the production of valacyclovir hydrochloride, which has the following beneficial effects:

[0014] 1. This multi-stage pulverizing device for the production of valacyclovir hydrochloride, by setting pulverizing blades and pulverizing rollers, allows the valacyclovir raw material to be added into the inside of the cylinder through the feed inlet during use. At this time, the first motor rotates and drives the pulverizing blades to rotate through the rotating shaft, thereby pulverizing the valacyclovir raw material. The pulverized raw material falls between two sets of pulverizing rollers through the guide hopper. At the same time, the second motor starts and drives the pulverizing rollers to rotate through the rotating rod, performing secondary pulverization on the pulverized raw material to prevent incomplete pulverization.

[0015] 2. This multi-stage pulverizing device for the production of valacyclovir hydrochloride features a hydraulic rod. When activated, the hydraulic rod moves the sliding plate, causing the rotating rod to move. This reduces or increases the distance between the two sets of pulverizing rollers, allowing the raw materials to be pulverized into different sizes as needed for subsequent use. Simultaneously, the second and third gears move upwards or downwards with the rotating rod, and are limited by the first and second connecting rods. This ensures that when the second motor drives the rotating rod, the two sets of pulverizing rollers rotate in corresponding directions, further pulverizing the raw materials. Attached Figure Description

[0016] Figure 1 This is a three-dimensional sectional view of the present invention;

[0017] Figure 2 This is a schematic diagram of the internal structure of this utility model;

[0018] Figure 3 This is a schematic diagram of the internal structure of the cylindrical body of this utility model;

[0019] Figure 4 This utility model Figure 1 Schematic diagram of the structure at point A;

[0020] Figure 5 This is a three-dimensional structural diagram of the present invention.

[0021] In the diagram: 1. Box body; 2. Cylinder body; 201. First motor; 202. Rotating shaft; 203. Crushing blade; 204. Feed inlet; 3. Guide hopper; 4. Support plate; 401. Through hole; 402. Slide plate; 403. Second motor; 404. Rotating rod; 405. Crushing roller; 5. First gear; 501. Second gear; 502. Third gear; 503. First connecting rod; 504. Second connecting rod; 6. Hydraulic rod; 7. Collection frame. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figure 1-5In this embodiment: a multi-stage pulverizing device for the production of valacyclovir hydrochloride includes a housing 1, a cylinder 2 fixedly installed on the top of the housing 1, a first motor 201 fixedly installed on the top of the cylinder 2, a feed inlet 204 opened on the side of the top of the cylinder 2 corresponding to the first motor 201, a guide hopper 3 fixedly installed inside the housing 1, two sets of support plates 4 fixedly installed inside the housing 1 corresponding to the bottom of the guide hopper 3, and a pulverizing roller 405 provided between the two sets of support plates 4.

[0024] In this embodiment, a rotating shaft 202 is fixedly installed at the output end of the first motor 201, and a crushing blade 203 is fixedly installed on the outer surface of the rotating shaft 202 and extends to the bottom of the cylinder 2. Valacyclovir raw material is added into the inside of the cylinder 2 through the feed port 204. At this time, the first motor 201 rotates and drives the crushing blade 203 to rotate through the rotating shaft 202, thereby crushing the valacyclovir raw material.

[0025] In this embodiment, a through hole 401 is provided on the support plate 4. Two sets of sliding plates 402 are slidably installed inside the through hole 401. A second motor 403 is fixedly installed on the outside of one set of sliding plates 402. A rotating rod 404 is rotatably installed between each pair of corresponding sliding plates 402. The crushing roller 405 is fixedly installed on the rotating rod 404.

[0026] In this embodiment, one end of one set of rotating rods 404 is fixedly connected to the second motor 403, and the other ends of both sets of rotating rods 404 extend to the outside of the slide plate 402 and are fixedly installed with the first gear 5. The two sets of first gears 5 are respectively hinged to the second gear 501 and the third gear 502.

[0027] In this embodiment, a first connecting rod 503 is rotatably mounted between one set of first gear 5, second gear 501, and third gear 502, and a second connecting rod 504 is rotatably mounted between another set of first gear 5 and second gear 501. The second gear 501 and third gear 502 are meshed together. When the distance between the two sets of crushing rollers 405 is adjusted, the second gear 501 and third gear 502 will move up or down with the movement of the rotating rod 404, and will be limited by the first connecting rod 503 and the second connecting rod 504, so that the two sets of rotating rods 404 can transmit power.

[0028] In this embodiment, two sets of symmetrically arranged hydraulic rods 6 are fixedly installed inside the housing 1 on the side of the support plate 4. The telescopic ends of the two sets of hydraulic rods 6 are rotatably connected to the rotating rod 404. By activating the hydraulic rods 6, the slide plate 402 drives the rotating rod 404 to move, thereby reducing or increasing the distance between the two sets of crushing rollers 405, so that the raw materials can be crushed into different specifications according to the requirements, which is convenient for subsequent use.

[0029] In this embodiment, a collection frame 7 is slidably installed inside the box 1 corresponding to the bottom of the crushing roller 405. One end of the collection frame 7 extends to the outside of the box 1 and a handle is fixedly installed. The crushed raw material falls into the inside of the collection frame 7 between the two sets of crushing rollers 405, and the collection frame 7 can be taken out by pulling the handle, so as to facilitate the subsequent processing of the crushed raw material.

[0030] The working principle and usage process of this utility model are as follows: Valacyclovir raw material is added into the inside of the cylinder 2 through the feed port 204. At this time, the first motor 201 rotates and drives the crushing blade 203 to rotate through the rotating shaft 202, thereby crushing the Valacyclovir raw material. The crushed raw material falls between the two sets of crushing rollers 405 through the guide hopper 3. At the same time, the second motor 403 is started and drives the crushing rollers 405 to rotate through the rotating rod 404, crushing the crushed raw material again. By activating the hydraulic rod 6, the sliding plate 402 drives the rotating rod 404 to move, thereby reducing or increasing the distance between the two sets of crushing rollers 405, so that the raw material can be crushed into different specifications according to the needs. The raw material crushed by the crushing rollers 405 falls into the inside of the collection frame 7 for collection.

[0031] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A multi-stage crushing device for producing valaciclovir hydrochloride, comprising a box body (1), a cylinder body (2) is fixedly installed on the top of the box body (1), characterized in that: The top of the barrel (2) is fixedly installed with a first motor (201), and a feeding port (204) is formed in the top of the barrel (2) corresponding to the side of the first motor (201); the inside of the box (1) is fixedly installed with a guide hopper (3), and two groups of support plates (4) are fixedly installed below the guide hopper (3) corresponding to the inside of the box (1); and a crushing roller (405) is arranged between the two groups of support plates (4).

2. A multi-stage pulverizing device for producing valacyclovir hydrochloride according to claim 1, characterized in that: The output end of the first motor (201) is fixedly installed with a rotating shaft (202), and the outer surface of the rotating shaft (202) is fixedly installed with a crushing blade (203) and extends to the bottom of the barrel (2).

3. The multi-stage crushing device for producing valaciclovir hydrochloride according to claim 1, characterized in that: A through hole (401) is formed in the support plate (4), and two groups of sliding plates (402) are slidingly installed in the through hole (401); the outer side of one group of the sliding plates (402) is fixedly installed with a second motor (403); a rotating rod (404) is rotatably installed between every two groups of corresponding sliding plates (402); and the crushing roller (405) is fixedly installed on the rotating rod (404).

4. The multi-stage crushing device for producing valaciclovir hydrochloride according to claim 3, characterized in that: One end of one group of the rotating rods (404) is fixedly connected with the second motor (403), and the other end of the two groups of rotating rods (404) extends to the outer side of the sliding plate (402) and is fixedly installed with a first gear (5); the two groups of first gears (5) are respectively hingedly installed with a second gear (501) and a third gear (502).

5. The multi-stage pulverizing device for producing valaciclovir hydrochloride according to claim 4, characterized in that: One group of the first gears (5) is rotatably installed with a first connecting rod (503) between the second gear (501) and the third gear (502), and the other group of the first gears (5) is rotatably installed with a second connecting rod (504) between the second gear (501); and the second gear (501) is meshingly connected with the third gear (502).

6. A multi-stage pulverizing device for producing valacyclovir hydrochloride according to claim 1, characterized in that: The inside of the box (1) is fixedly installed with two groups of symmetrically arranged hydraulic rods (6) corresponding to the side of the support plate (4); and the telescopic ends of the two groups of hydraulic rods (6) are rotatably connected with the rotating rod (404).

7. A multi-stage pulverizing device for producing valacyclovir hydrochloride according to claim 1, characterized in that: The inside of the box (1) is slidingly installed with a collecting frame (7) corresponding to the bottom of the crushing roller (405); and one end of the collecting frame (7) extends to the outside of the box (1) and is fixedly installed with a handle.

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