Efficient film evaporator for magnesium glycinate production

Abstract

The utility model discloses an efficient film evaporation device for magnesium glycinate production, and relates to the field of magnesium glycinate production equipment.The device comprises a cylindrical evaporation chamber, at least four heating jackets which are arranged on the outer surface of the evaporation chamber in the axial direction and independently control the temperature in a partition mode, an integrated heating rotor assembly and a controller; a feeding hole and a concentrated solution outlet are respectively formed in the upper end and the lower end of the evaporation chamber, and a lining layer is compounded on the inner wall of the evaporation chamber; each independent heating jacket is provided with a PID (Proportion Integration Differentiation) temperature control module connected with the controller, so that the plurality of independent heating jackets form stepped heating distribution along the material flowing direction; the rotor assembly includes a spiral vortex disk. According to the film evaporator, stepped temperature rise is formed in the material flowing direction through the multi-partition independent temperature control heating jacket and the PID module, the problem that the axial temperature field of traditional equipment is not uniform is effectively solved, a magnesium glycinate solution saturation solubility curve is accurately matched, and crystal form transformation caused by local overheating is avoided.

Description

Technical Field

[0001] This application relates to the field of equipment for the production of magnesium glycine, and in particular to a high-efficiency thin-film evaporator for the production of magnesium glycine. Background Technology

[0002] In the field of pharmaceutical intermediate production, magnesium glycinate, as an important chelating agent, directly affects the bioavailability of formulations due to its crystal morphology and particle size distribution. Currently, industrial production mainly employs thin-film evaporation crystallization technology, with conventional equipment often using a single-layer jacketed heating structure and overall temperature control via steam or heat transfer oil. Such devices suffer from insufficient axial temperature field uniformity during material flow, particularly when processing heat-sensitive materials, easily leading to localized overheating and crystal transformation. Existing evaporator rotors often employ purely mechanical stirring designs, with radial heat transfer relying primarily on the jacket's conduction. This results in internal temperature gradients exceeding 3°C, promoting the formation of impurities such as β-crystals. More significantly, traditional processes typically introduce seed crystals through mechanical stirring and crushing in the later stages of evaporation. This method suffers from uneven seed crystal dispersion and a particle size distribution dispersion coefficient exceeding 0.35, resulting in a product crystal purity level of only 85-90%.

[0003] In-depth analysis reveals that the shortcomings of existing technologies stem from the coupled effects of multiple technical bottlenecks. First, the single-temperature zone design cannot match the constantly changing saturation solubility curve of magnesium glycinate solution during evaporation and concentration. When the solution transitions from the metastable region to the supersaturated region, the lack of a precise gradient temperature control mechanism makes it difficult to control the crystal nucleation rate. Second, conventional rotors only have mechanical stirring functions and lack an integrated active heating unit. Under high-speed rotation conditions, a cold spot zone of 0.8-1.2℃ easily forms at the interface between the rotor surface and the material. This temperature difference directly disrupts the orientation consistency of crystal growth. Furthermore, the surface roughness of the traditional carbon steel inner wall, even after polishing, remains around Ra0.8μm. Microscopic grooves easily trap free crystal nuclei, forming non-directional crystallization centers, which is the root cause of crystal aggregation and scaling.

[0004] In summary, current thin-film evaporators used for magnesium glycinate production still have shortcomings in both structure and function. Utility Model Content

[0005] The purpose of this application is to overcome at least one deficiency of the prior art and to provide a high-efficiency thin-film evaporator for the production of magnesium glycine.

[0006] To achieve the above objectives, this application discloses a high-efficiency thin-film evaporation device for the production of magnesium glycine. The device includes a cylindrical evaporation chamber, at least four independently temperature-controlled heating jackets arranged axially on the outer surface of the evaporation chamber, an integrated heating rotor assembly, and a controller. The evaporation chamber has a feed inlet and a concentrated liquid outlet at its upper and lower ends, respectively.

[0007] The inner wall of the evaporator chamber is reinforced with an inner lining layer;

[0008] Each independent heating jacket is equipped with a PID temperature control module connected to the controller, so that the multiple independent heating jackets form a stepped temperature distribution along the material flow direction;

[0009] The rotor assembly includes a spiral vortex disk, and independent heating wire modules corresponding to the heating jacket partitions are embedded on the surface of the spiral vortex disk. Each independent heating wire module is connected to the controller and is controlled by the controller to work.

[0010] The concentrated liquid outlet at the lower end of the evaporation chamber is coaxially connected to the conical liquid collection buffer tank via a flange sealing assembly;

[0011] The bottom of the liquid collection buffer tank is provided with a discharge port, which is connected to the inlet pipeline of the centrifugal unloading pump via an electrically controlled rotary sealing valve; the rotary sealing valve is connected to the controller via a signal line and is controlled by the controller.

[0012] The outlet pipe of the centrifugal unloading pump is connected to the feed inlet at the top of the crystallizer, and the outer wall of the outlet pipe is covered with an electric heat tracing insulation layer.

[0013] The outlet pipeline is integrated with an ultrasonic atomizing seed crystal introduction device located in the crystallization vessel. The device includes a Venturi mixer connected to the outlet pipeline, an ultrasonic atomizing nozzle unit that supplies seed crystals to the Venturi mixer, and a seed crystal metering and supply component.

[0014] The metering supply assembly is connected to the atomizing nozzle unit via a diaphragm pump; the ultrasonic atomizing nozzle unit includes a piezoelectric transducer and an atomizing head inserted into a Venturi mixer.

[0015] Furthermore, the heating jacket adopts a heat transfer oil circulation structure, with a built-in serpentine heat exchange tube and forms a closed-loop temperature control system with the PID temperature control module.

[0016] Furthermore, the discharge port is equipped with a quick-release basket filter.

[0017] Furthermore, the Venturi mixer integrates a supersaturation monitoring probe connected to the controller.

[0018] Furthermore, the liquid collection buffer tank is equipped with a radar level sensor and a temperature sensor, both of which are connected to the controller for data transfer.

[0019] Compared with existing technologies, this thin-film evaporator utilizes a multi-zone independently temperature-controlled heating jacket and a PID module to achieve stepped heating along the material flow direction, effectively solving the problem of uneven axial temperature field in traditional equipment. It precisely matches the saturation solubility curve of the magnesium glycinate solution, avoiding localized overheating that could lead to crystal transformation. The integrated heating rotor assembly incorporates an independent heating wire module within a spiral vortex disk, eliminating cold spots on the rotor surface, enhancing material heat transfer efficiency and uniformity, and promoting consistent crystal growth orientation. A composite lining layer on the inner wall of the evaporation chamber reduces surface roughness, minimizes free crystal nucleus capture, inhibits the formation of non-directional crystallization centers, and reduces the risk of crystal aggregation and scaling. An ultrasonic atomization seed introduction device, combined with a Venturi mixer and seed metering supply component, achieves uniform seed dispersion and precise supply, reducing the particle size distribution dispersion coefficient and significantly improving product crystal purity. The collaborative operation of various sensors and controllers enables intelligent monitoring and control of the production process, further optimizing product quality and production efficiency. This overcomes multiple technical bottlenecks in traditional thin-film evaporation crystallization processes for magnesium glycinate production, providing a superior and more efficient solution for the pharmaceutical intermediates production field.

[0020] The beneficial effects listed above are not exhaustive of all advantages. Other potential beneficial effects and detailed technical implementation methods will be further disclosed in the embodiments or other descriptive sections of this application. Attached Figure Description

[0021] A better understanding of various aspects of this disclosure will be achieved by reading the following detailed description in conjunction with the accompanying drawings. The positions, dimensions, and extents of the structures shown in the drawings, etc., do not always represent actual positions, dimensions, and extents. In the drawings:

[0022] Figure 1 This is a schematic diagram of the structure of one embodiment disclosed in this application. Detailed Implementation

[0023] The present disclosure will now be described with reference to the accompanying drawings, which illustrate several embodiments of the present disclosure. However, it should be understood that the present disclosure can be presented in many different ways and is not limited to the embodiments described below; in fact, the embodiments described below are intended to make the disclosure more complete and to fully illustrate the scope of protection of the present disclosure to those skilled in the art. It should also be understood that the embodiments disclosed herein can be combined in various ways to provide further additional embodiments.

[0024] It should be understood that the same reference numerals denote the same elements in all the accompanying drawings. For clarity, the dimensions of certain features may be modified in the drawings.

[0025] It should be understood that the terminology used in this specification is for describing specific embodiments only and is not intended to limit this disclosure. All terms used in this specification (including technical and scientific terms) have the meanings commonly understood by those skilled in the art, unless otherwise defined. For the sake of brevity and / or clarity, techniques, methods, and apparatus known to those skilled in the art may not be discussed in detail; however, where appropriate, such techniques, methods, and apparatus should be considered part of this specification.

[0026] Unless otherwise specified, the singular forms “a,” “the,” and “the” used in this specification include the plural forms. The terms “comprising,” “including,” and “containing” used in this specification indicate the presence of the claimed feature but do not exclude the presence of one or more other features. The term “and / or” used in this specification includes any and all combinations of one or more of the relevant listed items.

[0027] The following is an example of a high-efficiency thin-film evaporation apparatus for the production of magnesium glycine:

[0028] See attached document Figure 1 This embodiment relates to a high-efficiency thin-film evaporation device for the production of magnesium glycinate. The device mainly includes a cylindrical evaporation chamber 1, made of corrosion-resistant and thermally conductive stainless steel to ensure stable operation and effective heat transfer in harsh chemical production environments. At least four independently temperature-controlled heating jackets 2 are arranged axially on the outer surface of the evaporation chamber 1. These heating jackets 2 employ a heat-conducting oil circulation structure and have built-in serpentine heat exchange tubes. Precise temperature control is achieved through a PID temperature control module connected to a controller 3, resulting in a stepped temperature distribution across the multiple independent heating jackets 2 along the material flow direction. This design principle is based on the different temperature requirements of the material at different stages of the magnesium glycinate production process. Gradual temperature increases effectively improve evaporation efficiency and ensure product quality. For example, in the initial stage, a lower temperature facilitates preliminary material concentration. As the material flows along the evaporation chamber, the gradually increasing temperature further promotes moisture evaporation, accelerating the production process.

[0029] In this embodiment, the integrated heating rotor assembly 4 is one of the key components of the device. It includes a spiral vortex disk, with independent heating wire modules corresponding to the partitions of the heating jacket 2 embedded on the disk surface. Each independent heating wire module is connected to and controlled by the controller 3. The spiral vortex disk in the integrated heating rotor assembly 4 is made of a high-strength corrosion-resistant alloy to withstand high-speed rotation and complex chemical environments.

[0030] The spiral vortex disk design enables the material to form a thin film within the evaporation chamber 1, increasing the contact area between the material and the heating surface, thereby improving the evaporation rate. The independent heating wire module further enhances the heating effect on the material, working in conjunction with the heating jacket 2 to ensure sufficient heat transfer within the evaporation chamber 1, achieving a highly efficient evaporation process.

[0031] Evaporation chamber 1 is equipped with a feed inlet and a concentrate outlet. The position and structure of the feed inlet are reasonably designed to facilitate the uniform entry of materials into evaporation chamber 1. The lower end of evaporation chamber 1 is coaxially connected to a conical liquid collection buffer tank 5 through a flange sealing assembly. The flange sealing assembly uses high-performance sealing materials, such as graphite composite gaskets, to ensure the sealing of the connection and prevent material leakage.

[0032] The conical liquid collection buffer tank 5 is made of stainless steel and has a discharge port at its bottom. The discharge port is connected to the inlet pipe of the centrifugal unloading pump 6 via an electrically controlled rotary sealing valve. The rotary sealing valve is connected to and controlled by the controller 3 via a signal line. This design can precisely control the material discharge process, preventing excessive accumulation of material in the conical liquid collection buffer tank 5 or excessively rapid discharge, thus ensuring the stability and continuity of the production process.

[0033] The centrifugal unloading pump is made of a composite structure of corrosion-resistant engineering plastic and stainless steel. Its outlet pipe is connected to the top feed port of the crystallizer 7, and the outer wall of the outlet pipe is covered with an electric heat tracing insulation layer. The electric heat tracing insulation layer uses a high-performance electric heat tracing tape, which can maintain the temperature of the material in the pipe and prevent the material from crystallizing and blocking the pipe due to temperature drop during transportation, ensuring that the material smoothly enters the crystallizer for subsequent crystallization operations.

[0034] In some implementation scenarios, each independent heating jacket 2 is equipped with a PID temperature control module connected to the controller. Through precise temperature control algorithms, the heating power can be automatically adjusted according to a preset temperature curve, ensuring that the temperature of the heating jacket 2 is always within the optimal range, thereby guaranteeing the stability and efficiency of the evaporation process. For example, in the production of magnesium glycine, when the initial concentration of the raw material liquid is low, the controller 3 will lower the temperature of the heating jacket 2 based on feedback signals to avoid excessive evaporation leading to material decomposition; while when the concentration of the raw material liquid gradually increases, the controller 3 will appropriately increase the temperature of the heating jacket 2 to accelerate the evaporation rate and improve production efficiency.

[0035] Furthermore, the inner wall of evaporation chamber 1 is lined with an inner lining layer made of corrosion-resistant materials such as polytetrafluoroethylene (PTFE). The thickness of the lining layer is determined according to actual production needs, generally 2-5 mm. This lining layer can effectively prevent materials from corroding evaporation chamber 1, extend the service life of the equipment, and at the same time ensure the purity of the product, avoiding the introduction of impurities due to equipment corrosion.

[0036] In actual operation, when the device starts, controller 3 first controls the heating jacket 2 and the heating wire module to begin heating, gradually increasing the temperature inside the evaporation chamber 1. Subsequently, the material enters the evaporation chamber through the feed inlet, forming a thin film under the action of the spiral vortex disk, and rapidly evaporating under the combined action of the heating jacket 2 and the heating wire module. As the evaporation process continues, the concentrated liquid gradually flows to the lower end of the evaporation chamber 1 and enters the conical collection buffer tank 5. When the liquid level in the buffer tank reaches a certain height, controller 3 controls the rotary sealing valve to open, and the centrifugal unloading pump 6 starts, transporting the concentrated liquid to the crystallization kettle 7. Throughout the entire process, all components work closely together, achieving automated operation from material evaporation to concentrated liquid delivery, greatly improving production efficiency and product quality.

[0037] More specifically, the conical liquid collection buffer tank 5 is equipped with a radar level sensor and a temperature sensor. The radar level sensor uses high-frequency radar technology to accurately measure the liquid level height of the material inside the buffer tank. The temperature sensor uses a high-precision thermistor to monitor the temperature of the material inside the buffer tank in real time. Both the radar level sensor and the temperature sensor are connected to the controller 3. By receiving the liquid level and temperature signals, the controller 3 can monitor the status of the material inside the buffer tank in real time and perform corresponding operations according to the preset control strategy, such as controlling the opening and closing of the rotary sealing valve and adjusting the speed of the centrifugal unloading pump 6, thereby ensuring the stability and continuity of the production process.

[0038] In addition, an ultrasonic atomizing seed crystal introduction device 8 is integrated at the end of the outlet pipeline. This device includes a Venturi mixer connected to the outlet pipeline, an ultrasonic atomizing nozzle unit that supplies seed crystals to the mixing chamber, and a seed crystal metering supply assembly. The metering supply assembly is connected to the atomizing nozzle unit via a diaphragm pump. The ultrasonic atomizing nozzle unit includes a piezoelectric transducer and an atomizing head inserted into the Venturi mixer. During use, the seed crystals are precisely metered by the metering supply assembly and then transported to the ultrasonic atomizing nozzle unit by the diaphragm pump. The piezoelectric transducer converts electrical energy into ultrasonic vibration energy, causing the seed crystals to be atomized into tiny particles at the atomizing head, which are then thoroughly mixed with the concentrate supplied from the outlet pipeline in the Venturi mixer. This design effectively promotes the growth of magnesium glycinate crystals, improving the crystallinity and purity of the product. For example, in the production of magnesium glycinate, introducing an appropriate amount of seed crystals into the concentrate provides a nucleus for the growth of magnesium glycinate crystals, making the crystals more uniform and complete during growth, thereby improving product quality and yield.

[0039] Furthermore, the discharge port is equipped with a quick-release basket filter with a stainless steel filter screen. The filtration precision can be selected according to actual production needs, generally 100-200 mesh. This filter can effectively remove impurities from the material, preventing them from entering the centrifugal discharge pump 6 and the subsequent crystallization kettle 7, thus ensuring product purity. At the same time, the quick-release design facilitates filter cleaning and replacement, improving equipment maintenance efficiency.

[0040] Furthermore, the Venturi mixer integrates a supersaturation monitoring probe connected to the controller 3. This probe employs an advanced optical sensor to monitor the supersaturation of the solution within the mixing chamber in real time. When the supersaturation of the solution reaches a certain value, the controller 3 automatically adjusts the seed crystal supply or the concentrate delivery speed to ensure that the magnesium glycine crystals can grow under optimal supersaturation conditions, thereby improving product quality and yield.

[0041] Through the rational design and close coordination of the aforementioned components, the high-efficiency thin-film evaporation device for glycine magnesium production in this embodiment can achieve a highly efficient, stable, and continuous production process, with significant beneficial effects. In actual production, this device can effectively improve the production efficiency and product quality of glycine magnesium, reduce production costs, and has broad prospects for widespread application.

[0042] While exemplary embodiments of this disclosure have been described, those skilled in the art will understand that various changes and modifications can be made to the exemplary embodiments of this disclosure without departing from the spirit and scope thereof. Therefore, all changes and modifications are included within the scope of protection of this disclosure as defined by the claims. This disclosure is defined by the appended claims, and equivalents of those claims are also included.

Claims

1. A high-efficiency thin-film evaporation apparatus for the production of magnesium glycine, characterized in that, The device includes a cylindrical evaporation chamber, at least four independently temperature-controlled heating jackets arranged axially on the outer surface of the evaporation chamber, an integrated heating rotor assembly, and a controller; the upper and lower ends of the evaporation chamber are respectively provided with a feed inlet and a concentrated liquid outlet, wherein the inner wall of the evaporation chamber is composite with an inner lining layer; Each independent heating jacket is equipped with a PID temperature control module connected to the controller, so that the multiple independent heating jackets form a stepped temperature distribution along the material flow direction; The rotor assembly includes a spiral vortex disk, and the surface of the spiral vortex disk is fitted with independent heating wire modules corresponding to the heating jacket partitions. Each independent heating wire module is connected to a controller and is controlled by the controller to operate. The concentrated liquid outlet at the lower end of the evaporation chamber is coaxially connected to a conical liquid collection buffer tank via a flange sealing assembly; the bottom of the liquid collection buffer tank is provided with a discharge port, which is connected to the inlet pipeline of a centrifugal unloading pump via an electrically controlled rotary sealing valve; The rotary sealing valve is connected to the controller via a signal line and is controlled by the controller to operate. The outlet pipe of the centrifugal unloading pump is connected to the feed inlet at the top of the crystallizer, and the outer wall of the outlet pipe is covered with an electric heat tracing insulation layer. The outlet pipeline end is integrated with an ultrasonic atomizing seed crystal introduction device located in the crystallization vessel. The device includes a Venturi mixer connected to the outlet pipeline, an ultrasonic atomizing nozzle unit that supplies seed crystals to the Venturi mixer, and a seed crystal metering and supply component. The metering supply assembly is connected to the atomizing nozzle unit via a diaphragm pump; the ultrasonic atomizing nozzle unit includes a piezoelectric transducer and an atomizing head inserted into a Venturi mixer.

2. The high-efficiency thin-film evaporation apparatus for the production of magnesium glycine as described in claim 1, characterized in that, The heating jacket adopts a heat transfer oil circulation structure, with built-in serpentine heat exchange tubes and forms a closed-loop temperature control system with the PID temperature control module.

3. The high-efficiency thin-film evaporation apparatus for the production of magnesium glycine as described in claim 1, characterized in that, The discharge port is equipped with a quick-release basket filter.

4. The high-efficiency thin-film evaporation apparatus for the production of magnesium glycine as described in claim 1, characterized in that, The Venturi mixer integrates a supersaturation monitoring probe connected to the controller.

5. The high-efficiency thin-film evaporation apparatus for the production of magnesium glycine as described in claim 1, characterized in that, The liquid collection buffer tank is equipped with a radar level sensor and a temperature sensor, both of which are connected to the controller for data transfer.

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