Turnover support applied to chromatographic column

Abstract

The overturning support comprises a base and the chromatographic column, a vertical pipe is arranged in the middle of the rear side of the base, an overturning rod is arranged on the front side face of the vertical pipe, a worm gear is arranged on the middle section of the overturning rod, a worm is arranged above the worm gear, a hand rotating handle is arranged on one side of the worm, and the worm can drive the worm gear to rotate by 180 degrees through the hand rotating handle. A clamping frame is arranged on the front side of the turnover rod, and the chromatographic column is clamped on the clamping frame. The upper part of the vertical pipe is respectively provided with the worm gear and the worm, the worm gear can rotate through the rotation of the worm, and the front side of the overturning rod is provided with the clamping frame, so that the chromatographic column can be overturned through the transmission of the worm gear and the worm, the structure is simple, and the practicability is strong; the two sides of the chromatographic column are clamped on the first fixed ring of the fixed frame and the second fixed ring of the movable frame respectively, so that the clamping effect is good, and the chromatographic column can be prevented from falling off in the overturning process; the chromatographic column overturning device is ingenious in design, simple in structure, capable of rapidly achieving overturning of the chromatographic column, convenient to load, unload and clean and suitable for popularization.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and more specifically to a flipping support applied to chromatography columns. Background Technology

[0002] Chromatographic separation and purification is a widely used process in recent years for protein separation and purification, plant extract separation and purification, and biopharmaceutical purification. Chromatographic separation and purification technology is particularly prevalent in laboratory separation and preparation. In laboratory chromatography, it is often necessary to invert the chromatography column to facilitate the packing material, unloading, and cleaning. Most commercially available column holders only have a clamping function and lack inverting capability, thus their limited functionality cannot meet the needs of chromatography experiments. Typically, the chromatography column is inverted 180 degrees, requiring real-time observation by the experimenter for better monitoring and control. To address this issue, the inventors propose a column inverting support for chromatography. This support first clamps the column, allowing the experimenter to invert it, thus better assisting in completing chromatography experiments and improving experimental quality.

[0003] To facilitate unloading of chromatography column packing material, promote cleaning, prevent column breakage, and ensure smooth chromatography operation, publication number CN212440147U discloses a chromatography column tilting frame. This utility model includes a tilting support, comprising at least a vertical support component and a horizontal support component, the horizontal support component being perpendicularly connected to the vertical support component; a chromatography column tilting assembly, comprising a tilting shaft and a chromatography column housing, the tilting shaft being rotatably connected to the horizontal support component, and the chromatography column housing being connected to the tilting shaft; the vertical and horizontal support components are arranged to allow the chromatography column housing, containing the chromatography column, to move within a range of 0–180 degrees from the vertical; and a power component is drively connected to the tilting shaft. This utility model simplifies and simplifies the addition of raw materials and cleaning processes, saving time and effort, reducing the risk of column breakage, effectively improving work efficiency, and eliminating safety hazards.

[0004] The proposed solution still has some shortcomings in application. Because the chromatography column is cylindrical, it needs to be properly clamped and secured before inversion. Otherwise, the column may easily detach and break during inversion, affecting the chromatography experiment and potentially causing injury. Furthermore, different scenarios before, during, and after the chromatography experiment require the column to be inverted at different angles. It needs to be able to not only invert to a set angle but also to remain fixed at that angle for easy loading, unloading, and cleaning. Therefore, the structure of the chromatography column inversion support needs to be improved so that it can not only effectively clamp and secure the column but also remain fixed at a set angle during inversion, better assisting operators and effectively improving the chromatography experiment results. Utility Model Content

[0005] This utility model discloses a flipping support for chromatography columns, the main purpose of which is to overcome the above-mentioned deficiencies and shortcomings of the prior art.

[0006] The technical solution adopted in this utility model is as follows:

[0007] A flipping support for a chromatography column includes a base and a chromatography column. A vertical tube is provided in the middle of the rear side of the base. A flipping rod is installed on the front side of the vertical tube. A worm gear is installed in the middle section of the flipping rod. The worm gear is provided with a meshing gear. A worm is installed above the worm gear. A hand handle is installed on one side of the worm. The worm can drive the worm gear to rotate 180 degrees through the hand handle. The rotation of the worm gear drives the flipping rod to rotate. A clamping frame is installed at the front end of the flipping rod. The chromatography column is movably clamped in the clamping frame.

[0008] Furthermore, the meshing gear is located on the upper part of the worm gear, at a 1 / 2 position.

[0009] Furthermore, the worm gear has a rotating thread in its middle section, which is adapted to mesh with the meshing gear.

[0010] Furthermore, the clamping frame includes a fixed frame and a movable frame. The fixed frame has a groove with a fixing knob at one end. The movable frame has a movable tube that is embedded in the groove and can slide left and right along the groove and can be fixed by the fixing knob.

[0011] Furthermore, the upper and lower parts of the fixed frame are provided with a first fixing ring, the upper and lower parts of the movable frame are provided with a second fixing ring, and the chromatography column is sandwiched between the first fixing ring and the second fixing ring.

[0012] Furthermore, the base is provided with a placement groove.

[0013] As can be seen from the above description of this utility model, compared with the prior art, the advantages of this utility model are as follows:

[0014] This invention firstly features worm gears on the upper part of the riser. The worm gears rotate via the worm shafts. The worm gears are also positioned in the middle of a flipping rod, with a clamping frame at the front. This design allows the chromatography column on the clamping frame to flip via the worm gear transmission. The meshing gears on the worm gears are set at a 1 / 2 angle, enabling the clamping frame to flip 180 degrees. The structure is simple yet highly practical. Next, the clamping frame includes a fixed frame and a movable frame. The chromatography column is clamped on both sides by the first fixing ring of the fixed frame and the second fixing ring of the movable frame, respectively. This provides a good clamping effect, preventing the column from falling off during flipping and ensuring the safety of the chromatography experiment. Finally, a hand-operated handle is located on the side of the riser, allowing the experimenter to observe the chromatography column while flipping it. The column is also very easy to load and unload, requiring only the operation of a fixing knob. This invention is ingeniously designed, simple in structure, and enables rapid column flipping with convenient loading and unloading, facilitating material loading, unloading, and cleaning, making it suitable for widespread application. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the front structure of this utility model. Figure 1 .

[0016] Figure 2 This is a schematic diagram of the front structure of this utility model. Figure 2 .

[0017] Figure 3 This is a side view of the structure of this utility model.

[0018] Figure 4 This is a front view schematic diagram of the worm gear and worm of this utility model.

[0019] Figure 5 This is a front view structural diagram of the fixed frame and the movable frame of this utility model. Detailed Implementation

[0020] The specific embodiments of this utility model will be further described below with reference to the accompanying drawings.

[0021] like Figures 1 to 5As shown, a flipping support for a chromatography column includes a base 1 and a chromatography column 2. A riser 3 is provided in the middle of the rear side of the base 1. A flipping rod 4 is installed on the front side of the riser 3. A worm gear 5 is installed in the middle section of the flipping rod 4. The worm gear 5 is provided with a meshing gear 51. A worm 6 is installed above the worm gear 5. A hand handle 7 is installed on one side of the worm 6. The worm 6 can drive the worm gear 51 to rotate 80 degrees through the hand handle 7. The rotation of the worm gear 5 drives the flipping rod 4 to rotate. A clamping frame 8 is installed at the front end of the flipping rod 4. The chromatography column 2 is movably clamped in the clamping frame 8.

[0022] Furthermore, the meshing gear 51 is disposed on the upper part of the worm gear 5, in a 1 / 2 configuration.

[0023] Furthermore, the worm gear 6 has a rotating thread 61 in the middle section, which is adapted to mesh with the meshing gear 51.

[0024] Furthermore, the clamping frame 8 includes a fixed frame 81 and a movable frame 82. The fixed frame 81 is provided with a groove 9, and a fixing knob 10 is provided at one end of the groove 9. The movable frame 82 is provided with a movable tube 11, which is embedded in the groove 9 and can slide left and right along the groove 9 and can be fixed by the fixing knob 10.

[0025] Furthermore, the upper and lower parts of the fixed frame 81 are provided with first fixing rings 12, the upper and lower parts of the movable frame 82 are provided with second fixing rings 13, and the chromatography column 2 is sandwiched between the first fixing ring 12 and the second fixing ring 13.

[0026] Furthermore, the base 1 is provided with a placement groove 14.

[0027] [Example]

[0028] First, the chromatography column 2 is placed between the fixed frame 81 and the movable frame 82 of the clamping frame 8. The movable tube 11 of the movable frame 82 is inserted into the first fixed ring 12 and the second fixed ring 13 along the groove 9 of the fixed frame 81 to clamp and fix the chromatography column 2. Then, the movable tube 11 is fixed in the groove 9 by the fixing knob 10, so that the chromatography column 2 is fixed on the clamping frame 8. Next, according to the experimental progress, the hand handle 7 is turned to drive the worm gear 6 to rotate. The rotation of the worm gear 6 drives the worm wheel 5 to rotate. The rotation of the worm wheel 5 drives the flipping rod 4 to rotate. The rotation of the flipping rod 4 drives the clamping frame 8 to rotate, so that the chromatography column 2 can be flipped. Since the meshing gear 51 is set on the upper part of the worm wheel 5 at a 1 / 2 position, the chromatography column 2 can be flipped 180 degrees, which is convenient for loading, unloading and cleaning. Finally, after the experiment, the hand handle 7 is turned in the opposite direction to make the chromatography column 2 flip back. Then, by turning off the fixing knob 10, the movable frame 82 is moved outward to remove the chromatography column 2.

[0029] As can be seen from the above description of this utility model, compared with the prior art, the advantages of this utility model are as follows:

[0030] This invention firstly features worm gears on the upper part of the riser. The worm gears rotate via the worm shafts. The worm gears are also positioned in the middle of a flipping rod, with a clamping frame at the front. This design allows the chromatography column on the clamping frame to flip via the worm gear transmission. The meshing gears on the worm gears are set at a 1 / 2 angle, enabling the clamping frame to flip 180 degrees. The structure is simple yet highly practical. Next, the clamping frame includes a fixed frame and a movable frame. The chromatography column is clamped on both sides by the first fixing ring of the fixed frame and the second fixing ring of the movable frame, respectively. This provides a good clamping effect, preventing the column from falling off during flipping and ensuring the safety of the chromatography experiment. Finally, a hand-operated handle is located on the side of the riser, allowing the experimenter to observe the chromatography column while flipping it. The column is also very easy to load and unload, requiring only the operation of a fixing knob. This invention is ingeniously designed, simple in structure, and enables rapid column flipping with convenient loading and unloading, facilitating material loading, unloading, and cleaning, making it suitable for widespread application.

[0031] The above are merely specific embodiments of this utility model, but the design concept of this utility model is not limited thereto. Any non-substantial improvements made to this utility model using this concept should be considered as infringing on the protection scope of this utility model.

Claims

1. A flip-over support for a chromatography column, characterized in that: The system includes a base and a chromatography column. A vertical tube is located in the middle of the rear side of the base. A flipping rod is installed on the front side of the vertical tube. A worm gear is installed in the middle section of the flipping rod. The worm gear has a meshing gear. A worm is installed above the worm gear. A hand handle is installed on one side of the worm. The worm can drive the worm gear to rotate 180 degrees through the hand handle. The rotation of the worm gear drives the flipping rod to rotate. A clamping frame is installed at the front end of the flipping rod. The chromatography column is movably clamped in the clamping frame.

2. The flip-over support for a chromatography column according to claim 1, characterized in that: The meshing gear is located on the upper part of the worm gear, and is positioned at 1 / 2.

3. The flip-over support for a chromatography column according to claim 1, characterized in that: The worm gear has a rotating thread in the middle section, which is adapted to mesh with the meshing gear.

4. The flip-over support for a chromatography column according to claim 1, characterized in that: The clamping frame includes a fixed frame and a movable frame. The fixed frame has a groove with a fixing knob at one end. The movable frame has a movable tube that is embedded in the groove and can slide left and right along the groove and can be fixed by the fixing knob.

5. The flip-over support for a chromatography column according to claim 4, characterized in that: The fixed frame has a first fixing ring at its upper and lower parts, the movable frame has a second fixing ring at its upper and lower parts, and the chromatography column is sandwiched between the first fixing ring and the second fixing ring.

6. The flip-over support for a chromatography column according to claim 1, characterized in that: The base has a placement groove.

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