Filtering device for medical materials
By designing a medical material filtration device, using a partition and temperature control device to filter at a suitable temperature, the adsorbent material adsorbs endotoxins, solving the problem of difficult removal of endotoxins in gelatin, achieving efficient and low-cost separation, and is suitable for large-scale production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-21
- Publication Date
- 2026-03-13
AI Technical Summary
Existing technologies are insufficient for efficiently removing endotoxins from gelatin, and traditional methods are costly and require complex equipment, making industrial application difficult.
Design a filtration device for medical materials, comprising a container, a partition, a filter membrane, an inlet, an outlet, an air inlet, and a temperature control device. The device is divided into first and second chambers by the partition. The flow of the mixture is promoted by the guide holes, the filter membrane, and high-pressure gas. The filtration is carried out at a suitable temperature by the temperature control device, and the adsorbent material adsorbs endotoxins.
It achieves efficient separation of endotoxins in gelatin, maintains the activity and quality of gelatin, reduces production costs and equipment complexity, and is suitable for large-scale industrial production.
Smart Images
Figure CN223988177U_ABST
Abstract
Description
Technical Field
[0001] This utility model pertains to medical material processing equipment, specifically relating to a filtration device for medical materials. Background Technology
[0002] Endotoxins are components of the outer membrane of Gram-negative bacterial cell walls, and their chemical composition is lipopolysaccharide (LPS). Endotoxins exhibit high toxicity in animals; even small amounts can induce systemic inflammatory response syndrome, multiple organ failure syndrome, and sepsis, thereby endangering the animal's life.
[0003] Gelatin raw materials used in medical devices generally contain endotoxins. Safety is a fundamental requirement for gelatin as a biomedical material, and endotoxins are one of the key safety indicators. Currently, ultrafiltration and extraction methods are commonly used to remove endotoxins from the polymers of materials. However, due to the sol-gel transformation characteristics, rheological properties, amphoteric nature of proteins, and the presence of trace impurities in gelatin, it remains difficult to efficiently remove endotoxins from gelatin.
[0004] Ultrafiltration separates molecules of different sizes by sieving and separating them under pressure. It allows molecules smaller than the membrane pore size to pass through the membrane while retaining larger molecules. However, ultrafiltration equipment is expensive, consumables are complex to maintain, and it suffers from problems such as low filtration efficiency and difficulty in industrialization.
[0005] The extraction method involves adding a surfactant to a solution containing endotoxins. The surfactant binds to the endotoxin molecules through nonpolar interactions, forming micelles. Further centrifugation or heating promotes the growth of these surfactant-endotoxin micelles. However, due to the sol-gel transformation characteristics, rheological properties, and temperature sensitivity of gelatin, current commercially available endotoxin filtration devices cannot control the temperature, preventing the method from being practically applied in industry. Utility Model Content
[0006] In view of the shortcomings of the prior art described above, the purpose of this utility model is to provide a filtration device for medical materials that can improve the separation efficiency of medical materials and endotoxins and reduce production costs.
[0007] To achieve the above and other related objectives, this utility model provides a filtration device for medical materials, comprising:
[0008] container;
[0009] A partition is disposed inside the container, the partition dividing the container into a first chamber and a second chamber, and the partition is provided with a flow guide hole connecting the first chamber and the second chamber;
[0010] The feed inlet is connected to the first chamber and is used to inject a mixture of medical materials and adsorbent materials for adsorbing impurities into the first chamber.
[0011] A filter membrane is disposed on the surface of the partition facing the first chamber. The filter membrane has micropores, the pore size of which is configured to allow the medical material to pass through and to intercept the adsorbent material that adsorbs the impurities.
[0012] The discharge port is connected to the second chamber and is used to discharge the medical material from the second chamber;
[0013] An air inlet, connected to the first chamber, is used to inject high-pressure gas into the first chamber;
[0014] A temperature control device is configured to regulate the temperature of at least the first chamber.
[0015] In an optional embodiment of this utility model, the diameter of the flow guide hole is 10μm-90μm.
[0016] In an optional embodiment of this utility model, the filter membrane is provided with micropores, and the pore size of the micropores is 0.25μm-0.5μm.
[0017] In an optional embodiment of this invention, the filter membrane is made of cellulose acetate.
[0018] In an optional embodiment of this utility model, the first chamber is provided with a pressure detection unit.
[0019] In an optional embodiment of this utility model, the first chamber is provided with a pressure relief valve, which is configured to close when the pressure in the first chamber is less than a preset value, and to open when the pressure in the first chamber is greater than the preset value.
[0020] In an optional embodiment of the present invention, the temperature control device includes a jacket, which is disposed on the outer wall of the container corresponding to at least the first chamber. The jacket is provided with an inlet for injecting a heat transfer medium into the jacket and an outlet for discharging the heat transfer medium from the jacket.
[0021] In an optional embodiment of this invention, the first chamber is located above the second chamber.
[0022] In an optional embodiment of the present invention, the container includes a cylindrical body, an upper cover, and a lower cover, wherein the upper cover and the lower cover are respectively detachably installed at the upper and lower ends of the cylindrical body.
[0023] In an optional embodiment of this utility model, the partition is disposed within the cylindrical body, and the partition is disposed near the lower end of the cylindrical body.
[0024] The technical advantages of this invention are as follows: The medical material filtration device of this invention divides the container into a first chamber and a second chamber through a partition, and provides flow guide holes on the partition to ensure the controllability of the flow path of the mixture of medical material and adsorbent material; the design of the inlet facilitates the injection of the mixture, while the selective filtration function of the filter membrane effectively separates the medical material and adsorbent material, ensuring the purity of the medical material; the design of the outlet facilitates the discharge of the filtered medical material, improving operational efficiency; the high-pressure gas injection function of the air inlet promotes the flow of the mixture and enhances the filtration effect; the temperature regulation function of the temperature control device ensures that the filtration process is carried out at a suitable temperature, avoiding denaturation or performance changes of the medical material due to temperature changes; the medical material filtration device of this invention can efficiently separate endotoxins from gelatin while maintaining the activity and quality of the gelatin, making it suitable for large-scale production and use. Attached Figure Description
[0025] Figure 1 This is a perspective view of the medical material filtration device provided in an embodiment of this utility model;
[0026] Figure 2 This is a side view of the medical material filtration device provided in an embodiment of this utility model;
[0027] Figure 3 yes Figure 2 AA section view;
[0028] Figure 4 yes Figure 3 A magnified view of part of I;
[0029] Figure 5 This is an exploded view of the medical material filtration device provided in an embodiment of this utility model. Detailed Implementation
[0030] The following specific examples illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. This utility model can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of this utility model. It should be noted that, unless otherwise specified, the following embodiments and features described therein can be combined with each other.
[0031] It should be noted that the illustrations provided in the following embodiments are only schematic representations of the basic concept of the present invention. Therefore, the illustrations only show the components related to the present invention and are not drawn according to the number, shape and size of the components in actual implementation. In actual implementation, the form, quantity and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex.
[0032] The medical material filtration device provided by this invention is used to separate harmful substances from medical materials, such as endotoxins from gelatin. The specific process is as follows: First, the gelatin is heated to a molten state. Then, an adsorbent material, such as activated carbon, is added to the gelatin. After the adsorbent material and gelatin are mixed evenly, the mixture is injected into the medical material filtration device provided by this invention. The filtration device can heat or cool the material to maintain it at a suitable temperature. The endotoxins in the gelatin are adsorbed onto the adsorbent material. When the mixture passes through the filtration device of this invention, the adsorbent material containing the endotoxins is trapped inside the filtration device, while the gelatin is discharged from the outlet of the filtration device, thus achieving the separation of endotoxins and gelatin.
[0033] Compared to ultrafiltration, which requires the removal of small-molecule endotoxins and necessitates the use of permeation membranes with extremely small pore sizes, complex manufacturing processes, and high material costs, this invention utilizes adsorbent materials with larger particle sizes. This reduces the requirements for filter media, allowing the use of filter media with larger pore sizes. Furthermore, the production process of these larger-pore filter media is simpler and cheaper, significantly reducing filter media costs. Simultaneously, the larger-pore filter media is less prone to clogging, has a longer service life, and reduces replacement frequency, further lowering consumable costs. Additionally, the small-pore membranes of ultrafiltration tend to result in slow filtration speeds and low flux, while the larger-pore filter media of this invention reduces resistance to the flow of the mixture, resulting in faster filtration speeds and significantly improved separation efficiency, making it more suitable for large-scale industrial production.
[0034] Compared with extraction methods, this invention uses adsorbent materials to directly adsorb endotoxins without the need for surfactants, thus avoiding the risk of introducing additional chemicals. Temperature control of the material is achieved through a medical-grade filtration device, solving the problem that traditional methods cannot be industrialized due to the temperature sensitivity of gelatin. The adsorbent materials effectively intercept endotoxins, making the separation process more efficient and controllable. Furthermore, this method simplifies the process flow, avoiding the complex micelle growth and subsequent separation steps of extraction methods, making it more suitable for large-scale industrial applications.
[0035] The following detailed description of the medical material filtration device of this utility model, with reference to specific embodiments, is as follows:
[0036] Please see Figure 1-5As shown, the medical material filtration device provided in the embodiment of this utility model includes a container 10, a partition 20, a feed inlet 101, a filter membrane 30, a discharge outlet 102, an air inlet 103, and a temperature control device 40. A partition 20 is disposed inside the container 10, dividing the container 10 into a first chamber 1001 and a second chamber 1002. The partition 20 has a flow guide hole 21 connecting the first chamber 1001 and the second chamber 1002. An inlet 101 is connected to the first chamber 1001 and is used to inject a mixture of medical material and adsorbent material into the first chamber 1001. The medical material may be, for example, gelatin, and the adsorbent material may be, for example, activated carbon. A filter membrane 30 is disposed on the surface of the partition 20 facing the first chamber 1001. The filter membrane 30 is configured to allow the medical material to pass through and to intercept the adsorbent material. An outlet 102 is connected to the second chamber 1002 and is used to discharge the medical material from the second chamber 1002. An air inlet 103 is connected to the first chamber 1001 and is used to inject high-pressure gas into the first chamber 1001. A temperature control device 40 is configured to regulate the temperature of at least the first chamber 1001.
[0037] The medical material filtration device of this invention divides the container 10 into a first chamber 1001 and a second chamber 1002 by a partition 20, and provides flow guide holes 21 on the partition 20 to ensure the controllability of the flow path of the mixture of medical material and adsorbent material. The design of the feed port 101 facilitates the injection of the mixture, while the selective filtration function of the filter membrane 30 effectively separates the medical material and adsorbent material, ensuring the purity of the medical material. The setting of the discharge port 102 facilitates the discharge of the filtered medical material, improving operational efficiency. The high-pressure gas injection function of the air inlet 103 promotes the flow of the mixture and improves the filtration effect. The temperature regulation function of the temperature control device 40 ensures that the filtration process is carried out at a suitable temperature, avoiding denaturation or performance changes of the medical material due to temperature changes. The medical material filtration device of this invention can efficiently separate endotoxins from gelatin while maintaining the activity and quality of the gelatin, and is suitable for large-scale production and use.
[0038] It should be understood that the filtration device for medical materials provided by this utility model can be used not only to separate endotoxins from gelatin, but also to separate harmful substances from other medical materials, such as agarose, carrageenan, and collagen. The activated carbon used as the adsorbent material can also be replaced by materials such as alumina or modified cellulose.
[0039] Please see Figure 4As shown, in an optional embodiment of this invention, the pore size of the guide hole 21 is 10μm-90μm, preferably 20μm-50μm. This pore size range achieves an effective balance between permeability and support. Too small a pore size will significantly reduce permeability, resulting in slow filtration speed, low flux, and increased energy consumption and operating costs; while too large a pore size may weaken the support strength of the filter membrane 30, affecting filtration accuracy and the interception effect of the adsorbent material. The pore size range of 10μm-90μm ensures both the high efficiency of medical material permeability and the effective interception and support of the adsorbent material by the filter membrane 30, thereby improving filtration efficiency while maintaining the stability and separation accuracy of the device.
[0040] In an optional embodiment of this invention, the filter membrane 30 is provided with micropores, the pore size of which is 0.25μm-0.5μm, preferably 0.4μm. This design, while ensuring efficient interception and adsorption of materials, significantly improves the permeability of medical materials. Compared with ultrafiltration membranes, the pore size of 0.25μm-0.5μm is larger, reducing the requirements for the manufacturing process of the filter membrane 30, thereby significantly reducing the cost of the filter membrane 30. At the same time, the larger pore size reduces filtration resistance, increases filtration speed and flux, and avoids the clogging problem caused by excessively small pore size in the ultrafiltration membrane 30. This embodiment achieves an optimized balance between cost, permeability, and separation efficiency, making it more suitable for large-scale industrial production.
[0041] In an optional embodiment of this invention, the filter membrane 30 is made of cellulose acetate. Cellulose acetate possesses good biocompatibility, chemical stability, and mechanical strength, enabling it to withstand the temperature and chemical environment during medical material processing. Furthermore, its uniform microporous structure allows for efficient interception and adsorption of materials, ensuring the smooth passage of medical materials. In addition, cellulose acetate is low in cost and easy to process, further reducing the production and maintenance costs of the filter membrane 30 and improving the economy and practicality of the medical material filtration device. It should be understood that in some alternative embodiments, cellulose acetate can be replaced with other materials, such as ceramic materials.
[0042] Please see Figure 1-3 As shown in Figure 5, in an optional embodiment of this utility model, the first chamber 1001 is provided with a pressure detection unit 104. The pressure detection unit 104 can monitor the pressure changes in the first chamber 1001 in real time, ensuring that the filtration process is carried out under optimal pressure conditions, avoiding a decrease in filtration efficiency or equipment damage due to excessively high or low pressure; at the same time, real-time feedback of pressure data helps to optimize operating parameters, improve process stability and separation efficiency, reduce energy consumption and operational risks, and further enhance the reliability of the medical material filtration device and the controllability of industrial production. In specific embodiments, the pressure detection unit 104 may be, for example, a pressure sensor, a pressure transmitter, a pressure gauge, etc.
[0043] Please see Figure 3 As shown, in an optional embodiment of this utility model, the first chamber 1001 is provided with a pressure relief valve 105. The pressure relief valve 105 is configured to close when the pressure in the first chamber 1001 is less than a preset value, and to open when the pressure in the first chamber 1001 is greater than the preset value. The pressure relief valve 105 can effectively ensure the safety and stability of the filtration process. When the pressure in the first chamber 1001 is less than the preset value, the pressure relief valve 105 closes, ensuring that the filtration process is carried out efficiently within the required pressure range; when the pressure exceeds the preset value, the pressure relief valve 105 automatically opens to release excess pressure in a timely manner, preventing the equipment from being damaged or endangered due to excessive pressure.
[0044] Please see Figure 3 As shown, in an optional embodiment of this utility model, the temperature control device 40 includes a jacket 14, which is disposed on the outer wall of the container 10 corresponding to at least the first chamber 1001. The jacket 14 is provided with an inlet 141 for injecting a heat transfer medium into the jacket 14 and an outlet 142 for discharging the heat transfer medium from the jacket 14. Compared with other temperature control methods, the jacket 14 temperature control method achieves a more uniform temperature distribution by uniformly covering the outer wall of the container 10 with the heat transfer medium, avoiding local overheating or overcooling. At the same time, by adjusting the temperature and flow rate of the heat transfer medium, more precise temperature control can be achieved, meeting the processing requirements of temperature-sensitive materials such as gelatin. In addition, the jacket 14 has a simple structure, is easy to maintain, and is suitable for large-scale industrial production. In some alternative embodiments, the temperature control device 40 may also be an electric heating device.
[0045] Please see Figure 3 As shown, in an optional embodiment of this invention, the first chamber 1001 is located above the second chamber 1002. This design utilizes gravity to allow the medical material to flow naturally downwards, reducing external power requirements, lowering energy consumption, and improving filtration efficiency. It should be understood that the positional distribution of the first chamber 1001 and the second chamber 1002 is not unique; for example, in some embodiments, the first chamber 1001 and the second chamber 1002 may be configured as horizontal pipes.
[0046] Please see Figure 1-3As shown in Figure 5, in an optional embodiment of this utility model, the container 10 includes a cylindrical body 11, an upper cover 12, and a lower cover 13. The upper cover 12 and the lower cover 13 are respectively detachably installed at the upper and lower ends of the cylindrical body 11. The container 10 adopts a cylindrical body 11 and a detachable upper cover 12 and lower cover 13 design, which facilitates the assembly, disassembly, and maintenance of the equipment. At the same time, it facilitates the cleaning of the filter membrane 30 and adsorbent material residue, thereby improving the operability and service life of the equipment.
[0047] Please see Figure 3 As shown, in an optional embodiment of this utility model, the partition 20 is disposed inside the cylindrical body 11, and the partition 20 is disposed near the lower end of the cylindrical body 11. This embodiment can maximize the utilization of the space of the container 10, extend the residence time of medical materials in the medical material filtration device, and improve the interception efficiency of the adsorbent material for endotoxins; at the same time, this design optimizes the material flow path, reduces filtration resistance, improves filtration speed and throughput, and enhances the separation effect of the device and the efficiency of industrial production.
[0048] In summary, the high-pressure gas injection function of the air inlet 103 of this invention promotes the flow of the mixture and improves the filtration effect; the temperature regulation function of the temperature control device 40 ensures that the filtration process is carried out at a suitable temperature, avoiding denaturation or performance changes of medical materials due to temperature changes; the specific pore size range of the guide hole 21 ensures both the high efficiency of medical material passage and the effective interception and support of the adsorbent material by the filter membrane 30, thereby improving filtration efficiency while maintaining the stability and separation accuracy of the device; the specific pore size of the filter membrane 30 reduces filtration resistance, increases filtration speed and throughput, and avoids clogging problems caused by excessively small pore size, achieving an optimized balance between cost, throughput, and separation efficiency.
[0049] The above embodiments are merely illustrative of the principles and effects of this utility model and are not intended to limit the scope of this utility model. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this utility model. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this utility model should still be covered by the claims of this utility model.
[0050] Throughout this description, numerous specific details, such as examples of components and / or methods, are provided to provide a complete understanding of embodiments of the present invention. However, those skilled in the art will recognize that embodiments of the present invention may be practiced without one or more of these specific details or by other devices, systems, components, methods, parts, materials, components, etc. In other instances, well-known structures, materials, or operations have not been specifically shown or described in detail to avoid obscuring aspects of embodiments of the present invention.
Claims
1. A filter device for medical materials, characterized by The container comprises: a container; a partition plate arranged inside the container, the partition plate separating the container into a first chamber and a second chamber, the partition plate being provided with a flow guide hole communicating the first chamber and the second chamber; a feed port communicating with the first chamber, for injecting a mixture of medical material and adsorbent material for adsorbing impurities into the first chamber; a filter membrane arranged on the surface of the partition plate facing the first chamber, the filter membrane being provided with micropores, the pore size of the micropores being configured to enable the medical material to pass through and to intercept the adsorbent material adsorbing the impurities; a discharge port communicating with the second chamber, for discharging the medical material in the second chamber; an air inlet port communicating with the first chamber, for injecting high-pressure gas into the first chamber; a temperature control device configured to adjust the temperature of at least the first chamber.
2. The filter device for medical use according to claim 1, wherein The pore size of the flow guide hole is 10-90 μm.
3. The filter device for medical use according to claim 1, wherein The pore size of the micropores is 0.25-0.5 μm.
4. The filter device for medical use according to claim 1, wherein The filter membrane is made of cellulose acetate.
5. The filter device for medical use according to claim 1, wherein The first chamber is provided with a pressure detection unit.
6. The filter device for medical use according to claim 1, wherein The first chamber is provided with a pressure relief valve, the pressure relief valve being configured to close when the pressure in the first chamber is less than a preset value, and to open when the pressure in the first chamber is greater than the preset value.
7. The filter device for medical use according to claim 1, wherein The temperature control device comprises a jacket arranged on the outer wall of the container corresponding to at least the first chamber, the jacket being provided with a liquid inlet port for injecting heat transfer medium into the jacket, and a liquid outlet port for discharging the heat transfer medium in the jacket.
8. The filter device for medical use according to claim 1, wherein The first chamber is located above the second chamber.
9. The filter device for medical use according to claim 1, wherein The container comprises a cylindrical body, an upper cover and a lower cover, the upper cover and the lower cover being detachably mounted on the upper and lower ends of the cylindrical body, respectively.
10. The filter device for medical use according to claim 9, wherein The partition plate is arranged in the cylindrical body, and the partition plate is arranged close to the lower end of the cylindrical body.