Biopharmaceutical mixing device

Abstract

The utility model discloses a mixing device for biopharmacy, which relates to the technical field of biopharmacy equipment and comprises a mixing bin, a plurality of raw material filter discs are fixedly mounted in the mixing bin and divide the inside of the mixing bin into a plurality of mixing sub-bins, a driving shaft is arranged at the center of the inside of the mixing bin, and the driving shaft is driven by the driving shaft. And one end of the driving shaft is in transmission connection with a driving assembly. The variable-speed motor is driven by the driving motor to work, and the variable-speed motor drives the driving shaft to rotate, so that the plurality of caking crushing components rotate in respective mixing sub-bins to crush and mix caking blocks in the mixing sub-bins until the caking blocks are thoroughly crushed and fully mixed in the mixing sub-bin at the lowermost end of the mixing bin; the target mixed product is obtained, so that the target mixed product meets the subsequent production requirements in the aspects of quality uniformity and stability.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical equipment technology, and in particular to a mixing device for biopharmaceutical applications. Background Technology

[0002] A mixing device for biopharmaceuticals is a mixing and stirring equipment specifically designed for the biopharmaceutical field. It uses mechanical stirring to fully mix various biopharmaceutical raw materials in precise proportions and according to specific process requirements, ensuring that the mixed product has uniform and stable quality and meets the production standards and quality control requirements of biopharmaceuticals.

[0003] For example, Chinese Patent Publication No. CN216367454U discloses a mixing and stirring device for biopharmaceuticals, including a mixing cylinder, a vertically arranged rotating cylinder installed in the inner cavity of the mixing cylinder, and a through cavity inside the rotating cylinder; the rotating cylinder includes a driving part, a reflux part and a stirring part from top to bottom, and an annular baffle plate is fixedly connected to the inner side of the connection between the reflux part and the driving part; the reflux part is provided with multiple reflux holes, and multiple stirring blades are fixedly connected to the outer surface of the stirring part; a lifting screw is coaxially arranged inside the rotating cylinder, and the lifting screw passes through the baffle plate.

[0004] However, pharmaceutical raw materials are prone to clumping during storage. If the clumped pharmaceutical raw materials are directly fed into the mixing equipment for stirring, the mixing will be insufficient, which will greatly reduce the uniformity and stability of the mixed product and will also have an extremely adverse effect on a series of subsequent pharmaceutical processes. Utility Model Content

[0005] The purpose of this invention is to solve the problem that pharmaceutical raw materials are prone to clumping during storage in the prior art. If the pharmaceutical raw materials containing clumping are directly fed into the mixing equipment for stirring, the mixing will be insufficient, which will greatly reduce the uniformity and stability of the mixed product. Therefore, a mixing device for biopharmaceuticals is proposed.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a mixing device for biopharmaceuticals, comprising a mixing chamber, wherein a plurality of raw material filter discs are fixedly installed inside the mixing chamber, the plurality of raw material filter discs dividing the interior of the mixing chamber into a plurality of mixing sub-chambers, a drive shaft is provided at the center of the interior of the mixing chamber, a drive assembly is connected to one end of the drive shaft, and a plurality of agglomeration breaking assemblies are fixedly connected to the outside of the drive shaft, the plurality of agglomeration breaking assemblies being respectively disposed inside the plurality of mixing sub-chambers.

[0007] Preferably, the agglomeration breaking assembly includes a mounting ring, agglomeration breaking rods, and an inner wall cleaning scraper. One end of each of the agglomeration breaking rods is fixedly connected to the outside of the mounting ring, and the other end of each of the agglomeration breaking rods is threadedly connected to one of the inner wall cleaning scrapers.

[0008] Preferably, a mounting screw is fixedly connected to the middle of one side of the inner wall cleaning scraper, and the mounting screw is threadedly connected to the inside of the other end of the agglomeration breaking rod.

[0009] Preferably, the two sides of the agglomeration breaking rod are respectively fixedly connected to agglomeration breaking plates by bolts.

[0010] Preferably, the drive assembly includes a drive motor and a speed changer, wherein the output end of the drive motor is connected to the input end of the speed changer, and the output end of the speed changer is connected to one end of the drive shaft.

[0011] Preferably, a sealing cover is movably engaged at the upper end of the mixing chamber, and the gearbox is fixedly installed on one side of the sealing cover.

[0012] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0013] 1. In this utility model, a drive motor drives a speed changer to work. The speed changer drives the drive shaft to rotate, causing several agglomeration crushing components to rotate in their respective mixing sub-compartments. This crushes and mixes the agglomerates inside the mixing sub-compartments until the agglomerates are completely crushed. The mixture is then fully mixed inside the mixing sub-compartment at the bottom of the mixing sub-compartment to obtain the target mixed product. This ensures that the target mixed product meets the requirements for subsequent production in terms of quality uniformity and stability.

[0014] 2. In this utility model, the agglomeration crushing rod is driven to collide with the agglomeration to crush the agglomeration. At the same time, one end of the inner wall cleaning scraper is attached to the inside of the mixing chamber to clean the inner wall of the mixing chamber, so as to avoid some raw materials remaining on the inner wall of the mixing chamber. In addition, the factory can select the appropriate agglomeration crushing plate to cooperate with the agglomeration crushing rod to crush the agglomeration according to the size of the agglomeration. Attached Figure Description

[0015] Figure 1 This invention provides a three-dimensional structural schematic diagram of a mixing device for biopharmaceutical applications;

[0016] Figure 2 This invention provides a schematic diagram of the internal structure of a mixing device for biopharmaceutical applications;

[0017] Figure 3 This invention provides a schematic diagram illustrating the connection relationship between the drive assembly and the drive shaft in a mixing device for biopharmaceutical applications.

[0018] Figure 4 This invention presents a three-dimensional structural diagram of an agglomeration and breaking component in a mixing device for biopharmaceutical applications.

[0019] Legend: 1. Mixing chamber; 11. Raw material filter plate; 12. Mixing sub-chamber; 13. Sealing cover plate; 2. Drive shaft; 3. Drive assembly; 31. Drive motor; 32. Gearbox; 4. Agglomeration crushing assembly; 41. Mounting ring; 42. Agglomeration crushing rod; 421. Agglomeration crushing plate; 43. Inner wall cleaning scraper; 431. Mounting screw. Detailed Implementation

[0020] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0021] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed in the following specification.

[0022] Example 1: As Figure 1 - Figure 4 As shown, this utility model provides a mixing device for biopharmaceuticals, including a mixing chamber 1. Several raw material filter discs 11 are fixedly installed inside the mixing chamber 1, dividing the interior of the mixing chamber 1 into several mixing sub-chambers 12. A drive shaft 2 is arranged at the center of the interior of the mixing chamber 1. A drive assembly 3 is drivenly connected to one end of the drive shaft 2. Several agglomeration breaking components 4 are fixedly connected to the outside of the drive shaft 2. The agglomeration breaking components 4 are respectively arranged inside the several mixing sub-chambers 12. The drive assembly 3 includes a drive motor 31 and a speed reducer 32. The output end of the drive motor 31 is drivenly connected to the input end of the speed reducer 32. The output end of the speed reducer 32 is drivenly connected to one end of the drive shaft 2. A sealing cover plate 13 is movably latched at the upper end of the mixing chamber 1. The speed reducer 32 is fixedly installed on one side of the sealing cover plate 13.

[0023] The specific setup and function of this embodiment are described below. The pharmaceutical raw materials to be mixed, which contain lumps, are poured into the mixing chamber 1. The lumps are isolated in the uppermost mixing sub-chamber 12 by the raw material filter plate 11, while some small lumps fall into the lower mixing sub-chamber 12 through the filter holes. The drive motor 31 drives the speed reducer 32 to work. The speed reducer 32 drives the drive shaft 2 to rotate, causing several lumps crushing components 4 to rotate in their respective mixing sub-chambers 12, crushing and mixing the lumps inside the mixing sub-chambers 12 until the lumps are completely crushed and fully mixed in the mixing sub-chamber 12 at the bottom of the mixing chamber 1, to obtain the target mixed product, so that the target mixed product meets the requirements of subsequent production in terms of quality uniformity and stability.

[0024] Example 2: Figure 1 - Figure 4 As shown, the biopharmaceutical mixing device of this utility model includes a mixing chamber 1. Several raw material filter discs 11 are fixedly installed inside the mixing chamber 1, dividing the interior of the mixing chamber 1 into several mixing sub-chambers 12. A drive shaft 2 is set at the center of the interior of the mixing chamber 1. One end of the drive shaft 2 is connected to a drive assembly 3. Several agglomeration breaking assemblies 4 are fixedly connected to the outside of the drive shaft 2. The agglomeration breaking assemblies 4 are respectively arranged inside the several mixing sub-chambers 12. The agglomeration breaking assembly 4 includes a mounting ring 41, agglomeration breaking rods 42 and an inner wall cleaning scraper 43. One end of the agglomeration breaking rods 42 is fixedly connected to the outside of the mounting ring 41, and the other end of the agglomeration breaking rods 42 is threadedly connected to the several inner wall cleaning scrapers 43. A mounting screw 431 is fixedly connected to the middle of one side of the inner wall cleaning scraper 43. The mounting screw 431 is threadedly connected to the inside of the other end of the agglomeration breaking rod 42. Agglomeration breaking plates 421 are fixedly connected to both sides of the agglomeration breaking rod 42 by bolts.

[0025] The overall effect of this embodiment is that when the agglomeration crushing component 4 rotates, the agglomeration crushing rod 42 collides with the agglomerates and crushes them. At the same time, one end of the inner wall cleaning scraper 43, because it is attached to the inside of the mixing chamber 1, cleans the inner wall of the mixing chamber 1, preventing some raw materials from remaining on the inner wall of the mixing chamber 1. In addition, the factory can select the appropriate agglomeration crushing plate 421 to cooperate with the agglomeration crushing rod 42 to crush the agglomerates according to the size of the agglomerates, thereby improving the crushing efficiency of the agglomerates. At the same time, when the agglomeration crushing plate 421 and the inner wall cleaning scraper 43 are damaged, the workers can disassemble and replace them individually, thereby extending the service life of the agglomeration crushing component 4.

[0026] The method of use and working principle of this device: The pharmaceutical raw materials to be mixed and containing lumps are poured into the mixing chamber 1. The lumps of pharmaceutical raw materials are isolated by the raw material filter plate 11 in the uppermost mixing sub-chamber 12, while some small lumps fall into the lower mixing sub-chamber 12 through the filter holes. The drive motor 31 drives the speed changer 32 to work. The speed changer 32 drives the drive shaft 2 to rotate, so that several lumps crushing components 4 rotate in their respective mixing sub-chambers 12, crushing and mixing the lumps inside the mixing sub-chambers 12 until the lumps are completely crushed and fully mixed in the mixing sub-chamber 12 at the bottom of the mixing chamber 1 to obtain the target mixed product.

[0027] When the agglomeration crushing component 4 rotates, the agglomeration crushing rod 42 collides with the agglomerates and crushes them. At the same time, one end of the inner wall cleaning scraper 43 is attached to the inside of the mixing chamber 1 and cleans the inner wall of the mixing chamber 1 to prevent some raw materials from remaining on the inner wall of the mixing chamber 1. In addition, the factory can select the appropriate agglomeration crushing plate 421 to cooperate with the agglomeration crushing rod 42 to crush the agglomerates according to the size of the agglomerates.

[0028] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.

Claims

1. A biopharmaceutical mixing device comprising a mixing chamber (1), characterized in that: The inside of the mixing bin (1) is fixedly provided with a plurality of raw material filter discs (11), a plurality of raw material filter discs (11) separate the inside of the mixing bin (1) into a plurality of mixing sub-bins (12), the center of the inside of the mixing bin (1) is provided with a driving shaft (2), one end of the driving shaft (2) is drivingly connected with a driving assembly (3), the outer side of the driving shaft (2) is fixedly connected with a plurality of lump breaking assemblies (4), a plurality of lump breaking assemblies (4) are respectively arranged in the interiors of a plurality of mixing sub-bins (12).

2. The mixing device for biopharmaceuticals according to claim 1, characterized in that The lump breaking assembly (4) comprises a mounting ring (41), a lump breaking rod (42) and an inner wall cleaning scraper (43), one end of each of a plurality of lump breaking rods (42) is fixedly connected to the outer side of the mounting ring (41), the other end of each of a plurality of lump breaking rods (42) is threadedly connected with a plurality of inner wall cleaning scrapers (43) respectively.

3. The mixing device for biopharmaceuticals according to claim 2, characterized in that The middle of one side of the inner wall cleaning scraper (43) is fixedly connected with a mounting screw rod (431), the mounting screw rod (431) is threadedly connected in the interior of the other end of the lump breaking rod (42).

4. The mixing device for biopharmaceuticals according to claim 3, characterized in that: The two sides of the lump breaking rod (42) are respectively fixedly connected with a lump breaking plate (421) through bolts.

5. The mixing device for biopharmaceuticals according to claim 1, characterized in that: The driving assembly (3) comprises a driving motor (31) and a speed changer (32), the output end of the driving motor (31) is drivingly connected with the input end of the speed changer (32), the output end of the speed changer (32) is drivingly connected with one end of the driving shaft (2).

6. The mixing device for biopharmaceuticals according to claim 5, characterized in that The upper end of the mixing bin (1) is movably clamped with a sealing cover plate (13), the speed changer (32) is fixedly mounted on one side of the sealing cover plate (13).

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