Bulk drug ammonification reaction tank suitable for rapid cooling of aminomethylbenzoic acid

Abstract

The utility model discloses a bulk drug ammonification reaction tank suitable for rapidly cooling aminomethylbenzoic acid, and belongs to the technical field of reaction tanks. The reaction tank disclosed by the utility model comprises a reaction tank body, a sleeve, a heat exchange tube, a heat dissipation bin and a circulating water pump, the sleeve is arranged in the reaction tank body; the heat exchange tube is arranged on the inner side of the sleeve; the liquid medicine in the reaction tank body circularly flows in and out of the sleeve and the heat exchange liquid circularly flows in the heat exchange pipe, the heat dissipation bin and the circulating water pump, so that quick heat exchange of the liquid medicine is realized. According to the reaction tank, the heat exchange capacity of the reaction tank to the liquid medicine is jointly improved through the flow circulation of the liquid medicine inside and outside the sleeve and the heat exchange circulation of the heat exchange liquid in the heat exchange pipe and the heat dissipation radiator, the heat exchange time is greatly shortened, and the heat exchange cost is reduced.

Description

Technical Field

[0001] This utility model belongs to the field of reaction vessel technology, specifically relating to an ammoniation reaction vessel for raw material tranexamic acid suitable for rapid cooling. Background Technology

[0002] Tranexamic acid, also known as 4-aminomethylbenzoic acid, is a procoagulant. The amination reaction of tranexamic acid involves reacting benzoic acid with ammonia to produce ammonium benzoate. The specific steps are: Benzoic acid preparation: Benzoic acid reacts with sodium hydroxide to produce sodium benzoate. This step is to protect the carboxyl group in benzoic acid from being destroyed in subsequent reactions; Amination reaction: Sodium benzoate reacts with ammonia to produce ammonium benzoate; Decarboxylation reaction: Under heating conditions, ammonium benzoate undergoes a decarboxylation reaction to produce tranexamic acid. This production process requires strict temperature control and is highly dependent on specialized reaction equipment.

[0003] Existing common active pharmaceutical ingredient (API) amination reactors require heating and stirring during API production. However, these reactors often suffer from slow cooling rates after stirring, which affects subsequent production. Therefore, a fast-cooling API amination reactor is needed to address this issue. Utility Model Content

[0004] The purpose of this invention is to provide an ammoniation reaction vessel for tranexamic acid raw material that is suitable for rapid cooling. By coordinating the flow and circulation of the liquid inside and outside the sleeve with the heat exchange circulation of the heat exchange liquid in the heat exchange tube and the heat dissipation radiator, the heat exchange efficiency of the reaction vessel for the liquid is improved.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows:

[0006] A reaction vessel for the rapid cooling of tranexamic acid raw material ammonia reaction includes a reaction vessel body, a sleeve, heat exchange tubes, a heat dissipation chamber, and a circulating water pump. The sleeve is disposed inside the reaction vessel body. The heat exchange tubes are disposed inside the sleeve. Rapid heat exchange of the drug solution is achieved by circulating the drug solution in and out of the sleeve and by circulating the heat exchange liquid in the heat exchange tubes, heat dissipation chamber, and circulating water pump.

[0007] Furthermore, an upper conversion water tank is fixedly installed at the center of the outer side of the top of the reaction vessel body, and a lower conversion water tank is fixedly installed at the center of the outer side of the bottom of the reaction vessel body.

[0008] Furthermore, hollow tubes are rotatably installed inside both the upper and lower conversion water tanks, and annular mounting plates are rotatably installed on the surface of the hollow tubes.

[0009] Further, the annular mounting plate surface of the upper end is fixedly provided with an annular meshing track one; and the inner side of the upper end of the reaction tank body is fixedly provided with an annular meshing track two.

[0010] Further, the sleeve is fixedly arranged between the two annular mounting plates, and the inner surface of the lower end side of the sleeve is fixedly provided with a propeller blade.

[0011] Further, the surface of the heat exchange pipe is provided with a plurality of groups of heat dissipation fins; the heat exchange pipe is arranged inside the sleeve, and the heat exchange pipe is fixedly arranged at the end of the upper and lower hollow pipes.

[0012] Further, the heat dissipation compartment is internally provided with a heat dissipation cold row and a heat dissipation fan; and the heat dissipation fan is arranged at the bottom of the heat dissipation cold row.

[0013] Further, the water inlet of the heat dissipation cold row is connected with the lower conversion water tank through a pipeline; the water outlet of the heat dissipation cold row is connected with the water inlet of the circulating water pump through a pipeline; and the water outlet of the circulating water pump is connected with the upper conversion water tank through a pipeline.

[0014] Compared with the prior art, the utility model has the advantages that:

[0015] (1) The reaction tank disclosed by the utility model realizes the circulation flow of the liquid medicine in and out of the sleeve through the rotation of the sleeve and the propeller blade, and improves the heat exchange efficiency of the liquid medicine.

[0016] (2) The reaction tank disclosed by the utility model realizes the circulation of the heat exchange liquid through the heat exchange system composed of the heat exchange pipe, the heat dissipation cold row, the heat dissipation fan and the circulating water pump, and the heat exchange of the liquid medicine in the reaction tank does not need to rely on other heat exchange equipment, and the heat exchange cost of the liquid medicine is greatly reduced.

[0017] (3) The utility model is cleverly designed in structure, utilizes the interaction between the gear and the meshing track, realizes the rotation of the stirring rod in the reaction tank, speeds up the stirring rate of the liquid medicine, and improves the uniform heat exchange efficiency of the liquid medicine.

[0018] (4) The heat dissipation fan is provided with a plurality of groups and is arranged in parallel at the bottom of the heat dissipation cold row, and the air cooling efficiency can be improved.

[0019] (5) The utility model improves the heat exchange capacity of the reaction tank for the liquid medicine through the flow circulation of the liquid medicine in and out of the sleeve and the heat exchange circulation of the heat exchange liquid in the heat exchange pipe and the heat dissipation cold row, greatly shortens the heat exchange time, and reduces the heat exchange cost. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is a whole internal structure schematic view of the utility model;

[0021] Figure 2 It is the sleeve three-dimensional structure schematic view of the utility model;

[0022] Figure 3 It is the heat exchange pipe three-dimensional structure schematic view of the utility model;

[0023] Figure 4 It is the sleeve top view structure schematic view of the utility model.

[0024] The figure mark is: 1, annular meshing track one;2, gear one;3, annular mounting plate;4, stirring rod;5, reaction tank body;6, sleeve;7, heat exchange pipe;8, propeller blade;9, lower conversion water tank;10, heat dissipation bin;11, heat dissipation cold row;12, heat dissipation fan;13, hollow pipe;14, annular meshing track two;15, gear two;16, circulating water pump;17, upper conversion water tank;18, motor. Specific implementation

[0025] The utility model is further explained below in combination with the drawings.

[0026] Please refer to the attached Figures 1-4 A raw material medicine ammoniation reaction tank suitable for rapid cooling of aminomethylbenzoic acid, which comprises a reaction tank body 5, a sleeve 6, a heat exchange pipe 7, a stirring rod 4, a motor 18, a heat dissipation bin 10 and a circulating water pump 16;The sleeve 6 is arranged inside the reaction tank body 5;The heat exchange pipe 7 is arranged inside the sleeve 6;The stirring rod 4 is arranged inside the reaction tank body 5 and symmetrically arranged on the left and right sides of the sleeve 6;The motor 18 is arranged at the top end of the reaction tank body 5;The heat dissipation bin 10 is arranged below the reaction tank body 5;The circulating water pump 16 is fixedly arranged at the top end of the reaction tank body 5.

[0027] The upper end side of the reaction tank body 5 is provided with a feed inlet, and the lower end side of the reaction tank body 5 is provided with a discharge outlet;The upper end outside center of the reaction tank body 5 is fixedly provided with an upper conversion water tank 17, and the bottom end outside center of the reaction tank body 5 is fixedly provided with a lower conversion water tank 9;The inside of the upper conversion water tank 17 and the lower conversion water tank 9 is rotatably provided with a hollow pipe 13, and the surface of the hollow pipe 13 is rotatably provided with an annular mounting plate 3;Among them, the surface of the upper annular mounting plate 3 is fixedly provided with an annular meshing track one 1;The inside of the upper end of the reaction tank body 5 is fixedly provided with an annular meshing track two 14.

[0028] The sleeve 6 is fixedly arranged between the two annular mounting plates 3, and the lower end side inner surface of the sleeve 6 is fixedly provided with a propeller blade 8;When the sleeve 6 rotates, the propeller blade 8 can be driven to rotate and operate, thereby sucking the liquid in the reaction tank body 1 into the sleeve 6 from bottom to top.

[0029] The surface of the heat exchange pipe 7 is provided with a plurality of groups of heat dissipation fins, the heat exchange pipe 7 is arranged inside the sleeve 6, and the heat exchange pipe 7 is fixedly arranged at the end of the upper and lower hollow pipes 13.

[0030] The stirring rod 4 is rotatably arranged in the inner side of the edge of the annular mounting plate 3, and a gear two 15 is fixedly arranged at the upper end of the stirring rod 4 and is in meshing connection with an annular meshing track two 14 fixedly arranged in the inner side of the upper end of the reaction tank body 5.

[0031] The motor 18 is fixedly arranged at the top end of the reaction tank body 5, and the output end of the motor 18 is drivingly provided with a gear one 2, which is in meshing connection with an annular meshing track one 1 fixedly arranged on the surface of the annular mounting plate 3. When the motor 18 is started, the output end of the motor 18 drives the gear one 2 to rotate, and the rotating gear one 2 transmits power to the annular meshing track one 1 in meshing connection with the gear one 2, thereby driving the annular mounting plate 3 to rotate.

[0032] The heat dissipation bin 10 is located directly below the reaction tank body 5, and the heat dissipation bin 10 is internally provided with a heat dissipation cold row 11 and a heat dissipation fan 12; the heat dissipation fan 12 is arranged at the bottom of the heat dissipation cold row 11, and the heat dissipation fan 12 can effectively cool the heat exchange liquid entering the heat dissipation cold row 11; the water inlet of the heat dissipation cold row 11 is connected with the lower conversion water tank 9 through a pipeline; and the water outlet of the heat dissipation cold row 11 is connected with the water inlet of the circulating water pump 16 through a pipeline. The water outlet of the circulating water pump 16 is connected with the upper conversion water tank 17 through a pipeline.

[0033] As an example of the utility model, the hollow pipe 13 is rotatably provided with a sleeve ring, and the sleeve ring is fixedly connected with the annular mounting plate 3 through a fixed rod.

[0034] As an example of the utility model, the centers of the annular meshing track one 1 and the annular meshing track two 14 are coincided with the center of the hollow pipe 13 (i.e. the centers of the three are located at the same central axis).

[0035] As an example of the utility model, the heat dissipation fan 12 is provided with multiple groups and is arranged in parallel at the bottom of the heat dissipation cold row 11, so as to accelerate the air cooling efficiency.

[0036] As an example of the utility model, the heat exchange pipe 7 is provided with multiple groups and is fixedly arranged at the end of the hollow pipe 13, so as to increase the contact area of the medicinal liquid in the reaction tank body 5 and the heat exchange liquid and improve the heat exchange efficiency.

[0037] As an example of the utility model, the stirring rod 4 is fixedly provided with multiple groups of stirring blades, so as to increase the stirring efficiency of the stirring rod 4 on the medicinal liquid in the reaction tank body 5 and improve the heat exchange effect of the medicinal liquid.

[0038] The working principle of the utility model is as follows: when normally used, the feed inlet on the upper end side of the reaction tank body 5 is opened, the discharge outlet on the lower end side of the reaction tank body 5 is closed, and the aminomethylbenzoic acid liquid is added into the reaction tank body 5 through the feed inlet on the upper end side of the reaction tank body 5. At this time, the motor 18 is started, the output end of the motor 18 drives gear one 2 to rotate, the rotating gear one 2 transmits power to the annular meshing track one 1 meshed and connected therewith, and further drives the annular mounting plate 3 and the sleeve 6 fixedly arranged between the two annular mounting plates 3 to rotate on the surface of the hollow pipe 13. The rotating annular mounting plate 3 drives the stirring rod 4 arranged on the inner side of the edge to revolve (with the central axis of the hollow pipe 13 as the revolving center), when the stirring rod 4 revolves, the gear two 15 at the top end of the stirring rod 4 moves in the inner side of the annular meshing track two 14, so that the rotation of the stirring rod 4 is realized, and the stirring effect of the stirring rod 4 on the liquid in the reaction tank body 5 is greatly improved.

[0039] When the sleeve 6 rotates, the propeller blade 8 at the bottom rotates, and the rotating propeller blade 8 can draw the liquid in the reaction tank body 5 into the inner side of the sleeve 6 from bottom to top. And with the continuous rotation of the propeller blade 8, the liquid is continuously drawn into the inner side of the sleeve 6, and finally the liquid fills the sleeve 6, and is discharged from the upper end of the sleeve 6 and reenters the reaction tank body 5, so as to complete a cycle. In the circulation process, the circulating water pump 16 pumps the heat exchange liquid into the upper conversion water tank 17, drives the heat exchange liquid to move in the heat exchange pipe 7 through the hollow pipe 13, exchanges heat for the liquid in the sleeve 6, and the heat-exchanged heat exchange liquid enters the heat dissipation cold row 11 through the lower conversion water tank 9, and is air-cooled by the heat dissipation fan 12, and the heat-dissipated heat exchange liquid enters the circulating water pump 16 through the pipe, and is pumped into the upper conversion water tank 17 by the circulating water pump 16 again, and enters the heat exchange pipe 7 through the hollow pipe 13 again, and circulates for rapid heat exchange.

[0040] Through the circulation and heat exchange of the liquid between the sleeve 6 and the reaction tank body 5 and the circulation and heat exchange of the heat exchange liquid between the heat exchange pipe 7 and the heat dissipation cold row 11, the heat exchange and cooling process of aminomethylbenzoic acid is accelerated. When the aminomethylbenzoic acid liquid is cooled, the motor 18 is closed, the discharge outlet on the lower end side of the reaction tank body 5 is opened, and the heat-exchanged aminomethylbenzoic acid liquid is discharged from the reaction tank.

[0041] The above only describes the preferred embodiments of the utility model and is not used to limit the utility model, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model should be included in the protection scope of the utility model.

Claims

1. A reaction vessel for the rapid cooling of tranexamic acid, characterized in that, It includes a reaction tank body (5), a sleeve (6), a heat exchange tube (7), a heat dissipation chamber (10), and a circulating water pump (16); the sleeve (6) is located inside the reaction tank body (5); the heat exchange tube (7) is located inside the sleeve (6); the liquid medicine in the reaction tank body (5) circulates in and out of the sleeve (6) and the heat exchange liquid circulates in the heat exchange tube (7), the heat dissipation chamber (10), and the circulating water pump (16) to achieve rapid heat exchange of the liquid medicine.

2. The ammoniation reaction vessel for rapid cooling of tranexamic acid as described in claim 1, characterized in that, An upper conversion water tank (17) is fixedly installed at the center of the outer side of the top of the reaction tank body (5), and a lower conversion water tank (9) is fixedly installed at the center of the outer side of the bottom of the reaction tank body (5).

3. The ammoniation reaction vessel for rapid cooling of tranexamic acid as described in claim 2, characterized in that, Hollow tubes (13) are rotatably installed on the inner side of both the upper conversion water tank (17) and the lower conversion water tank (9), and an annular mounting plate (3) is rotatably installed on the surface of the hollow tubes (13).

4. The ammoniation reaction vessel for rapid cooling of tranexamic acid as described in claim 3, characterized in that, The upper annular mounting plate (3) is fixedly provided with an annular meshing track one (1); the upper inner side of the reaction vessel body (5) is fixedly provided with an annular meshing track two (14).

5. The ammoniation reaction vessel for rapid cooling of tranexamic acid as described in claim 1, characterized in that, The sleeve (6) is fixedly installed between two annular mounting plates (3), and a propeller blade (8) is fixedly installed on the inner surface of the lower side of the sleeve (6).

6. The ammoniation reaction vessel for rapid cooling of tranexamic acid as described in claim 1, characterized in that, The heat exchange tube (7) has several sets of heat dissipation fins on its surface; the heat exchange tube (7) is located inside the sleeve (6) and is fixedly located at the end of the upper and lower hollow tubes (13).

7. The ammoniation reaction vessel for rapid cooling of tranexamic acid as described in claim 1, characterized in that, The heat dissipation chamber (10) is equipped with a heat dissipation radiator (11) and a heat dissipation fan (12); the heat dissipation fan (12) is located at the bottom of the heat dissipation radiator (11).

8. The ammoniation reaction vessel for rapid cooling of tranexamic acid as described in claim 7, characterized in that, The inlet of the heat dissipation radiator (11) is connected to the lower conversion water tank (9) through a conduit; the outlet of the heat dissipation radiator (11) is connected to the inlet of the circulating water pump (16) through a conduit; and the outlet of the circulating water pump (16) is connected to the upper conversion water tank (17) through a pipe.

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