Raw material medicine freeze-drying plate layer

Abstract

The utility model discloses a bulk drug freeze-drying plate layer, which comprises an upper panel and a lower panel, the upper panel comprises a main body part and an inclined surface part which is arranged around the main body part and is obliquely arranged upwards, and a first heat exchange medium runner is arranged between the inclined surface part and the lower panel; and a second heat exchange medium runner is arranged between the main body part and the lower panel, and is communicated with the first heat exchange medium runner. The inclined surface parts are arranged on the periphery of the upper panel, and the first heat exchange medium flow channels between the inclined surface parts and the lower panel are communicated with the second heat exchange medium flow channels between the main body part and the lower panel, so that the surface temperatures of the inclined surface parts are basically consistent, and the surface temperatures of the inclined surface parts and the main body part are basically consistent; and the liquid medicine can be more dispersed, so that the heating and cooling time of the plate layer is shortened, the freeze-drying period is shortened, and the production efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to a freeze dryer, especially to a raw material medicine freeze-drying plate layer. BACKGROUND

[0002] Different from the medicine of freeze-drying of the west Lin bottle loading or freeze-drying disc loading, the raw material medicine generally freeze-dries directly on the freeze-drying plate layer, in order to prevent the medicine liquid from flowing out and facilitate the discharge after freeze-drying, the existing raw material medicine freeze-drying plate layer is generally designed as one side upwardly folding, and the rest of the edges are installed with the surrounding plate. The surface temperature consistency of the folding edge and the rest of the edges of the freeze-drying plate layer of this structure has slight difference, and the freeze-drying time is relatively long, which reduces the production efficiency to a certain extent. SUMMARY

[0003] The utility model wants to solve the technical problem that the prior art is overcome, provides a raw material medicine freeze-drying plate layer with simple structure, and the temperature uniformity and production efficiency are improved.

[0004] To solve the above technical problem, the utility model adopts the following technical scheme:

[0005] A raw material medicine freeze-drying plate layer, including upper panel and lower panel, the upper panel includes main part and is arranged in the inclined surface department of the surrounding and inclined upwardly, the inclined surface department with the lower panel between being equipped with the first heat exchange medium flow channel, the main part with the lower panel between being equipped with the second heat exchange medium flow channel, the second heat exchange medium flow channel with the first heat exchange medium flow channel intercommunication.

[0006] As the further improvement of the above technical scheme: the upper edge of the inclined surface department with the edge of the lower panel between being equipped with the outer sealing strip, the edge of the main part with the lower panel between being equipped with the inner sealing strip, the first heat exchange medium flow channel is located between the outer sealing strip and the inner sealing strip, and the second heat exchange medium flow channel is located in the region surrounded by the inner sealing strip.

[0007] As a further improvement of the above technical solution: the outer sealing strip comprises first outer sealing strip, second outer sealing strip, third outer sealing strip and fourth outer sealing strip connected in sequence, one end of the first outer sealing strip close to the second outer sealing strip is provided with a first heat exchange medium inlet, one end of the third outer sealing strip close to the fourth outer sealing strip is provided with a first heat exchange medium outlet, the inner sealing strip comprises first inner sealing strip, second inner sealing strip, third inner sealing strip and fourth inner sealing strip connected in sequence, the first inner sealing strip is located on the inner side of the first outer sealing strip, the third inner sealing strip is arranged on the inner side of the third outer sealing strip, one end of the third inner sealing strip close to the fourth inner sealing strip is provided with a second heat exchange medium inlet, one end of the fourth inner sealing strip is provided with a first blocking part connected with the third outer sealing strip, one end of the first inner sealing strip close to the second inner sealing strip is provided with a second heat exchange medium outlet, and one end of the second inner sealing strip is provided with a second blocking part connected with the first outer sealing strip.

[0008] As a further improvement of the above technical solution: the inclined surface part and the outer sealing strip are connected by fillet welding, and the lower panel and the outer sealing strip are connected by fillet welding; the main body part and the inner sealing strip are connected by fillet welding, and the lower panel and the inner sealing strip are connected by fillet welding.

[0009] As a further improvement of the above technical solution: a plurality of flow guide pipes are further arranged between the main body part and the lower panel, and the flow guide pipes are located in the second heat exchange medium flow channel.

[0010] As a further improvement of the above technical solution: the flow guide pipe is a rectangular pipe.

[0011] As a further improvement of the above technical solution: the main body part and the flow guide pipe are connected by vacuum brazing, and the lower panel and the flow guide pipe are connected by vacuum brazing.

[0012] As a further improvement of the above technical solution: the main body part is a rectangular part, and the lower panel is a rectangular plate.

[0013] As a further improvement of the above technical solution: the main body part and the inclined surface part are integrally formed.

[0014] As a further improvement of the above technical solution: the upper panel is formed by punching and forming a plate.

[0015] Compared with the prior art, the utility model has the advantages that:

[0016] The utility model discloses raw material medicine freeze-drying plate layer, the upper panel all is equipped with inclined surface part around, and the first heat medium flow channel communication main part between the inclined surface part and lower panel and the second heat medium flow channel between lower panel, be favorable to make the surface temperature of each inclined surface part basically identical, and the surface temperature of inclined surface part and main part is basically identical, and can make the liquid medicine more dispersed, be favorable to shorten the plate layer temperature rising time, and then shorten freeze-drying period, improve production efficiency.

[0017] Other features and advantages of the utility model will be described in the following specific embodiment part in detail. DRAWINGS

[0018] Figure 1 It is the overhead structure schematic diagram of raw material medicine freeze-drying plate layer of the utility model.

[0019] Figure 2 It is the overhead structure schematic diagram of the inside of raw material medicine freeze-drying plate layer of the utility model.

[0020] Figure 3 It is the cross section structure schematic diagram of the utility model transversely.

[0021] Figure 4 It is the cross section structure schematic diagram of the utility model longitudinally.

[0022] The various reference numerals in the drawings represent:

[0023] 1, upper panel;11, main part;12, inclined surface part;2, lower panel;3, inner sealing strip;31, second heat medium inlet;32, second heat medium outlet;33, first inner sealing strip;34, second inner sealing strip;341, second plugging part;35, third inner sealing strip;36, fourth inner sealing strip;361, first plugging part;4, outer sealing strip;41, first heat medium inlet;42, first heat medium outlet;43, first outer sealing strip;44, second outer sealing strip;45, third outer sealing strip;46, fourth outer sealing strip;5, flow guide pipe;61, first heat medium flow channel;62, second heat medium flow channel. SPECIFIC EMBODIMENT

[0024] In the description of the utility model, need understanding, the orientation or position relation that the terms "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" indicate is based on the orientation or position relation shown in the drawing, only for the convenience of describing the utility model and simplifying the description, and not indicate or imply the device or element that is indicated must have the specific orientation, with the specific orientation configuration and operation, therefore can not be understood as the limitation to the utility model.

[0025] In addition, the terms "first", "second", "third", "fourth", "fifth", "sixth", "seventh" and "eighth" are only used for descriptive purpose and cannot be understood as indicating or implying relative importance or implying the number of the technical features indicated. Therefore, the features defined with "first", "second", "third", "fourth", "fifth", "sixth", "seventh" and "eighth" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more than two, unless otherwise specifically defined.

[0026] In the present application, unless otherwise specifically defined and limited, the terms "assembly", "connection", "connection", "fixing" and the like should be understood in a broad sense, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements. For ordinary skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0027] The present application will be further described in detail below in combination with the drawings and specific embodiments of the present application.

[0028] Figures 1 to 4 An embodiment of the raw material drug freeze-drying plate layer of the present application is shown, the raw material drug freeze-drying plate layer of the embodiment comprises an upper panel 1 and a lower panel 2, the upper panel 1 comprises a main body part 11 and a slope part 12 arranged obliquely upward around the main body part 11, a first heat exchange medium flow channel 61 is arranged between the slope part 12 and the lower panel 2, a second heat exchange medium flow channel 62 is arranged between the main body part 11 and the lower panel 2, and the second heat exchange medium flow channel 62 communicates with the first heat exchange medium flow channel 61. Wherein, the heat exchange medium can be commonly used silicon oil and the like.

[0029] The raw material drug freeze-drying plate layer of the embodiment, the upper panel 1 is provided with the slope part 12 around, and the first heat exchange medium flow channel 61 between the slope part 12 and the lower panel 2 communicates with the second heat exchange medium flow channel 62 between the main body part 11 and the lower panel 2, which is beneficial to make the surface temperature of each slope part 12 substantially consistent, and the surface temperature of the slope part 12 and the main body part 11 substantially consistent, and can make the liquid more dispersed, which is beneficial to shorten the plate layer temperature rising time, and further shorten the freeze-drying cycle, improve the production efficiency.

[0030] Specific reference Figure 2In the embodiment, the outer sealing strip 4 is arranged between the upper edge of the inclined surface part 12 and the edge of the lower panel 2, the inner sealing strip 3 is arranged between the edge of the main body part 11 and the lower panel 2, the first heat exchange medium flow channel 61 is located between the outer sealing strip 4 and the inner sealing strip 3, and the second heat exchange medium flow channel 62 is located in the region enclosed by the inner sealing strip 3. The outer sealing strip 4 is used to seal the gap between the inclined surface part 12 and the lower panel 2, and can also provide support for the inclined surface part 12, thereby improving the structural strength of the panel layer. The inner sealing strip 3 is used to seal the gap between the main body part 11 and the lower panel 2, and can also provide support for the main body part 11, thereby improving the structural strength of the panel layer and separating the first heat exchange medium flow channel 61 and the second heat exchange medium flow channel 62, so that the heat exchange medium flows along the designed path.

[0031] Further, in the embodiment, the outer sealing strip 4 comprises a first outer sealing strip 43, a second outer sealing strip 44, a third outer sealing strip 45 and a fourth outer sealing strip 46 connected in sequence, the first outer sealing strip 43 is provided with a first heat exchange medium inlet 41 at one end close to the second outer sealing strip 44, the third outer sealing strip 45 is provided with a first heat exchange medium outlet 42 at one end close to the fourth outer sealing strip 46, the inner sealing strip 3 comprises a first inner sealing strip 33, a second inner sealing strip 34, a third inner sealing strip 35 and a fourth inner sealing strip 36 connected in sequence, the first inner sealing strip 33 is located on the inner side of the first outer sealing strip 43, the third inner sealing strip 35 is located on the inner side of the third outer sealing strip 45, the third inner sealing strip 35 is provided with a second heat exchange medium inlet 31 at one end close to the fourth inner sealing strip 36, the fourth inner sealing strip 36 is provided with a first blocking part 361 connected with the third outer sealing strip 45 at one end, the first inner sealing strip 33 is provided with a second heat exchange medium outlet 32 at one end close to the second inner sealing strip 34, and the second inner sealing strip 34 is provided with a second blocking part 341 connected with the first outer sealing strip 43 at one end. For details, see Figure 2 In operation, the heat exchange medium enters from the first heat exchange medium inlet 31, then flows along the lower section of the first heat exchange medium flow channel 61, then flows along the left section of the first heat exchange medium flow channel 61, and then enters the second heat exchange medium flow channel 62 through the second heat exchange medium inlet 31 after encountering the first blocking part 361, and then flows out from the second heat exchange medium outlet 32, and then returns to the right section of the first heat exchange medium flow channel 61. Due to the second blocking part 341, the heat exchange medium can only flow into the upper section of the first heat exchange medium flow channel 61, and finally flows out from the first heat exchange medium outlet 42. The flow path of the heat exchange medium completely covers the region between the upper panel 1 and the lower panel 2, which is conducive to keeping the surface temperature of the upper panel 1 uniform.

[0032] As a preferred embodiment, the inclined surface part 12 and the outer sealing strip 4 are connected by fillet welding, and the lower panel 2 and the outer sealing strip 4 are connected by fillet welding; the main body part 11 and the inner sealing strip 3 are connected by fillet welding, and the lower panel 2 and the inner sealing strip 3 are connected by fillet welding, which is convenient to process and is conducive to ensuring the sealing performance of the welded parts.

[0033] Further, in the embodiment, the plurality of flow guide pipes 5 are arranged between the main body 11 and the lower plate 2, and the flow guide pipes 5 are arranged in the second heat exchange medium flow channel 62, so that the flow path of the heat exchange medium in the second heat exchange medium flow channel 62 is further optimized, and the heat exchange medium and the liquid medicine are fully heat exchanged.

[0034] As a preferred embodiment, the flow guide pipe 5 is a rectangular pipe.

[0035] As a preferred embodiment, the main body 11 and the flow guide pipe 5 are connected by vacuum brazing, and the lower plate 2 and the flow guide pipe 5 are connected by vacuum brazing, which is beneficial to ensure the welding quality and the strength of the welding position.

[0036] As a preferred embodiment, the main body 11 is a rectangular part, and the lower plate 2 is a rectangular plate. Of course, in other embodiments, other shapes can also be used.

[0037] As a preferred embodiment, the main body 11 and the inclined surface part 12 are integrally formed, and specifically, the upper plate 1 is manufactured by punching and forming a plate, which is convenient and efficient, and is beneficial to make the surface temperature of each inclined surface part 12 of the plate layer substantially uniform. Of course, in other embodiments, the upper plate 1 can also be obtained by machining.

[0038] Although the present application has been disclosed with the preferred embodiments, it is not intended to limit the present application. Any person skilled in the art, without departing from the technical scheme of the present application, can make many possible changes and modifications to the technical scheme of the present application by using the disclosed technical content, or modify equivalent embodiments. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present application shall fall within the scope of protection of the technical scheme of the present application.

Claims

1. A freeze-dried plate layer for a pharmaceutical raw material, comprising an upper panel (1) and a lower panel (2), characterized in that: The upper panel (1) includes a main body (11) and an inclined surface (12) arranged around the main body (11) and at an angle upward. A first heat exchange medium flow channel (61) is provided between the inclined surface (12) and the lower panel (2). A second heat exchange medium flow channel (62) is provided between the main body (11) and the lower panel (2). The second heat exchange medium flow channel (62) is connected to the first heat exchange medium flow channel (61).

2. The lyophilized plate layer of the active pharmaceutical ingredient according to claim 1, characterized in that: An outer sealing strip (4) is provided between the upper edge of the inclined surface (12) and the edge of the lower panel (2), and an inner sealing strip (3) is provided between the edge of the main body (11) and the lower panel (2). The first heat exchange medium flow channel (61) is located between the outer sealing strip (4) and the inner sealing strip (3), and the second heat exchange medium flow channel (62) is located in the area enclosed by the inner sealing strip (3).

3. The lyophilized plate layer of the active pharmaceutical ingredient according to claim 2, characterized in that: The outer sealing strip (4) includes a first outer sealing strip (43), a second outer sealing strip (44), a third outer sealing strip (45), and a fourth outer sealing strip (46) connected end to end. The first outer sealing strip (43) has a first heat exchange medium inlet (41) at one end near the second outer sealing strip (44), and the third outer sealing strip (45) has a first heat exchange medium outlet (42) at one end near the fourth outer sealing strip (46). The inner sealing strip (3) includes a first inner sealing strip (33), a second inner sealing strip (34), a third inner sealing strip (35), and a fourth inner sealing strip (36) connected end to end. The first inner sealing strip (33) has a first inner sealing strip (33), a second inner sealing strip (34), a third inner sealing strip (35), and a fourth inner sealing strip (36) connected end to end. The third inner sealing strip (35) is located inside the first outer sealing strip (43). The third inner sealing strip (35) is located inside the third outer sealing strip (45). The third inner sealing strip (35) has a second heat exchange medium inlet (31) at one end near the fourth inner sealing strip (36). The fourth inner sealing strip (36) has a first sealing part (361) connected to the third outer sealing strip (45) at one end. The first inner sealing strip (33) has a second heat exchange medium outlet (32) at one end near the second inner sealing strip (34). The second inner sealing strip (34) has a second sealing part (341) connected to the first outer sealing strip (43) at one end.

4. The lyophilized plate layer of the active pharmaceutical ingredient according to claim 2, characterized in that: The inclined surface (12) is connected to the outer sealing strip (4) by fillet weld, and the lower panel (2) is connected to the outer sealing strip (4) by fillet weld; the main body (11) is connected to the inner sealing strip (3) by fillet weld, and the lower panel (2) is connected to the inner sealing strip (3) by fillet weld.

5. The lyophilized plate layer of the active pharmaceutical ingredient according to claim 1, characterized in that: Multiple guide pipes (5) are provided between the main body (11) and the lower panel (2), and the guide pipes (5) are located in the second heat exchange medium channel (62).

6. The lyophilized plate layer of the active pharmaceutical ingredient according to claim 5, characterized in that: The guide tube (5) is a rectangular tube.

7. The lyophilized plate layer of the active pharmaceutical ingredient according to claim 5, characterized in that: The main body (11) and the guide pipe (5) are connected by vacuum brazing, and the lower panel (2) and the guide pipe (5) are connected by vacuum brazing.

8. The lyophilized plate layer of the active pharmaceutical ingredient according to any one of claims 1 to 7, characterized in that: The main body (11) is a rectangular part, and the lower panel (2) is a rectangular plate.

9. The lyophilized plate layer of the active pharmaceutical ingredient according to any one of claims 1 to 7, characterized in that: The main body (11) and the inclined part (12) are integrally formed structures.

10. The lyophilized plate layer of the active pharmaceutical ingredient according to claim 9, characterized in that: The upper panel (1) is formed by stamping a sheet metal.

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