Sample analyzer

Abstract

The utility model provides a sample analyzer which comprises a box body, a blood routine examination assembly and a protein detection integrated module, and the box body comprises a first mounting area extending along a first path direction and a second mounting area positioned beside the first mounting area; the blood routine examination assembly is arranged in the first mounting area of the box body, and the protein detection integrated module is detachably assembled and connected to the second mounting area of the box body. In the utility model, the protein detection integrated module forms an independent specific protein detection system, the protein detection integrated module is assembled and combined by utilizing the limited space of the box body, and the blood routine model is formed by disassembling the protein detection integrated module part; and the protein detection integrated module part is a specific protein model, so that switching and upgrading of the protein model can be realized. In a protein model, the protein detection integrated module can be independently detached to be replaced or overhauled, meanwhile, the overhaul space of the blood routine examination assembly is reserved by detaching the protein detection integrated module, and maintenance is more convenient.

Description

TECHNICAL FIELD

[0001] The utility model relates to blood sample analysis technical field especially relates to a sample analyzer. BACKGROUND

[0002] In the hospital clinical especially in the maternal and child care hospital, usually carries out blood sampling to the patient and carries out the examination to the blood sample collected, the routine is the blood routine test mostly, but also has the blood routine test and the specific protein combined detection, in the blood routine and the specific protein combined detection analyzer, the multiple reaction pools needed in the blood routine detection are arranged, such as HGB reaction pool, WNB reaction pool, RBC reaction pool, RET reaction pool and DIFF reaction pool, and the reagent port of the refrigeration assembly containing the in-machine storage latex reagent is also contained on the motion track. If the analyzer contains at least 2 specific protein detection items, then more reaction pool assemblies need to be arranged on the track of the blood routine sampling distribution module movement, which is not conducive to the layout of the instrument, resulting in a longer depth direction of the instrument. Therefore, in order to shorten the space of the instrument, the specific protein detection related components are arranged on one side of the blood routine detection related components, and a swing arm structure is arranged between the two components. The sample liquid is transferred from one side of the blood routine detection related components to one side of the specific protein detection related components through the swing arm structure. In this way, the specific protein detection related components and the blood routine detection related components will block each other, resulting in insufficient maintenance space.

[0003] Therefore, there is an urgent need for an analyzer that does not extend the instrument space, is convenient to maintain, and ensures the detection effect. UTILITY MODEL CONTENT

[0004] In view of the above-mentioned shortcomings of the prior art, the purpose of the utility model is to:

[0005] Provide a kind of sample analyzer, its key is, including:

[0006] Box, including the first installation area along the first path direction extension and the second installation area located in the first installation area side;

[0007] Blood routine detection component, is arranged in the first installation area of the box and is used for collecting, distributing and detecting sample liquid, and the blood routine detection component distributes sample liquid along the first path;

[0008] Protein detection integrated module, at least including reagent refrigeration warehouse, immune detection pool unit and the combination module integrated by transfer unit;Sample liquid and reagent of the reagent refrigeration warehouse are transferred to the immune detection pool unit along the second path by the transfer unit, and the reagent refrigeration warehouse and immune detection pool unit are distributed on the second path, and the first path intersects with the second path;

[0009] The protein detection integrated module is detachably assembled and connected to the second mounting area of the box body.

[0010] In the first implementation, the second path is a straight line trajectory and a circular arc trajectory; the circular arc trajectory is connected with the straight line trajectory and intersects with the first path; the transfer unit comprises a swing block for mounting a reagent needle, a first power device for driving the swing block to complete the straight line trajectory movement, and a gear set for driving the swing block to complete the circular arc trajectory movement.

[0011] The transfer unit is located above the reagent refrigeration bin and the immune detection cell unit, the reagent refrigeration bin and the immune detection cell unit are arranged along the straight line trajectory, and the intersection area of the circular arc trajectory and the first path is provided with a premixing pool for receiving and pretreating sample liquid from the routine blood test assembly.

[0012] Based on the first implementation, the straight line trajectory is parallel to the first path, and the reagent refrigeration bin and the immune detection cell unit are staggered with the routine blood test assembly in a direction perpendicular to the straight line trajectory.

[0013] Based on the first implementation, the first power device comprises a top plate, a first straight line guide rail arranged on the top plate and along the straight line trajectory, a sliding seat sliding back and forth along the first straight line guide rail, and a first motor driving the sliding seat to slide, and the swing block moves synchronously with the sliding seat.

[0014] Based on the first implementation, the gear set comprises a fixed block, a driving gear rotatingly arranged on the fixed block, and a rack, the fixed block moves synchronously with the sliding seat, the rack is arranged on the straight line trajectory path of the driving gear and located at the connection area of the straight line trajectory and the circular arc trajectory, the swing block is mounted on the driving gear and rotates synchronously, and the outer end of the swing block is mounted with the reagent needle. The reagent needle moves from the reagent refrigeration bin to the immune detection cell unit, after passing through the immune detection cell unit, the reagent needle continues to move, the driving gear starts to mesh with the rack and rotate,

[0015] Based on the first implementation, the transfer unit further comprises a second power device for driving the first power device to move up and down, the second power device comprises a vertical plate mounted on the sliding seat and a second straight line guide rail and a second motor arranged on the vertical plate, the fixed block is slidingly arranged on the second straight line guide rail, and the second motor drives the fixed block, the driving gear and the swing block to move up and down synchronously relative to the first power device.

[0016] In the second implementation, the second path is a continuous circular arc trajectory, the transfer unit comprises a swing arm for mounting a reagent needle, a driving device for driving the swing arm to rotate, and a circuit control assembly for controlling the reagent needle to draw reagent, the swing arm is provided with a fixing portion at an outer end thereof for mounting the reagent needle, the fixing portion is located above the immunodetection cell unit and the reagent refrigeration bin, and the reagent needle on the swing arm swings to form the circular arc trajectory and transfer reagent and / or sample liquid under the driving of the driving device.

[0017] Based on the second implementation, the protein detection integrated module further comprises an integrated seat, the reagent refrigeration bin, the immunodetection cell unit, and the transfer unit are integrally mounted on the integrated seat, and the protein detection integrated module is detachably assembled to the second mounting area of the box body through the integrated seat.

[0018] Based on the second implementation, in the first aspect, the driving device and the circuit control assembly are located below the swing arm and are mounted on the integrated seat, a cover body is arranged on the integrated seat, the immunodetection cell unit, the reagent refrigeration bin, the driving device, and the circuit control assembly are located in the cover body, the cover body is provided with reagent collection openings corresponding to the immunodetection cell unit and the reagent refrigeration bin for the reagent needle to transfer reagent, and the swing arm is arranged outside the cover body and transfers reagent outside the cover body.

[0019] Based on the first aspect, the integrated seat and the cover body are arranged outside the box body and are provided with a reagent replacement opening, the reagent replacement opening is directed to a direction in which a front surface of the box body is located, and the reagent replacement opening is used to push or draw reagent in the reagent refrigeration bin in the direction.

[0020] Based on the first aspect, the protein detection integrated module further comprises a premixing pool for receiving and pre-processing sample liquid from the blood routine detection assembly, the premixing pool is integrally mounted on the integrated seat together with the reagent refrigeration bin, the immunodetection cell unit, and the transfer unit and is located in the cover body, the premixing pool is located at an intersection of the first path and the second path, and the cover body is provided with a sample liquid collection opening corresponding to the premixing pool.

[0021] Based on the second implementation, in the second aspect, the integrated seat comprises a base and a frame arranged on the base, the reagent refrigeration bin and the immunodetection cell unit are arranged on the base and are arranged along the circular arc trajectory, the frame extends upward and is provided with a mounting portion at an upper space of the reagent refrigeration bin and the immunodetection cell unit, the mounting portion mounts the driving device and the circuit control assembly, and the swing arm of the transfer unit is arranged below the driving device.

[0022] Based on the second aspect, the immunodetection cell unit is located at an intersection area of the first path and the second path.

[0023] Based on the second aspect, the protein detection integrated module is installed or removed from the first side of the housing along the third path direction. The second installation area is provided with multiple guides arranged along the third path direction for guiding the installation of the protein detection integrated module. The second installation area is also provided with multiple positioning components for limiting the installation stroke of the protein detection integrated module.

[0024] In some implementations, the routine blood test assembly includes a routine blood collection unit for collecting and dispensing sample fluid and at least two routine blood test units for receiving sample fluid for testing, wherein the sampling needle of the routine blood collection unit dispenses sample fluid along the first path.

[0025] In some implementations, the circular trajectory of the reagent needle does not interfere with the horizontal movement of the sampling needle.

[0026] As described above, the secondary battery of this invention has at least the following beneficial effects:

[0027] 1. The protein detection integrated module integrates a reagent cooling chamber, an immunoassay unit, and a transfer unit, achieving modular integration and forming an independent specific protein detection system. It can be assembled and combined using the limited space of the box. Removing the protein detection integrated module makes it a blood routine test machine; adding the protein detection integrated module makes it a specific protein test machine, which can realize the switching and upgrading of protein test machines.

[0028] 2. In protein testing models, the protein detection integrated module can be removed and replaced or repaired separately. Removing the protein detection integrated module also frees up space for the maintenance of the blood routine testing components, making maintenance more convenient. Attached Figure Description

[0029] Figure 1 This is an overall assembly drawing of a sample analyzer according to the first specific embodiment of the present invention;

[0030] Figure 2 This is a top-plane schematic diagram of a sample analyzer according to the first specific embodiment of the present invention;

[0031] Figure 3 This is a schematic diagram of the structure of a protein detection integrated module of a sample analyzer according to the first specific embodiment of the present invention;

[0032] Figure 4 This is an overall assembly drawing of a sample analyzer shown in the second specific embodiment of the present invention;

[0033] Figure 5 This is a top-plane schematic diagram of a sample analyzer according to a second specific embodiment of the present invention;

[0034] Figure 6 The exploded view of the protein detection integrated module and the box of the sample analyzer shown in the second specific embodiment of the utility model;

[0035] Figure 7 The structure view of the protein detection integrated module of the sample analyzer shown in the second specific embodiment of the utility model;

[0036] Figure 8 The overall assembly view of the sample analyzer shown in the third specific embodiment of the utility model;

[0037] Figure 9 The downward plane distribution view of the sample analyzer shown in the third specific embodiment of the utility model;

[0038] Figure 10 The structure view of the protein detection integrated module of the sample analyzer shown in the third specific embodiment of the utility model

[0039] Figure 11 The structure view of the left side of the box;

[0040] Figure 12 The structure view of the right side of the box.

[0041] Wherein, the reference signs are as follows:

[0042] Box 1, front plate 11, rear plate 12, left side plate 13, right side plate 14, top cover 15, bottom plate 16, middle partition plate 17, liquid path partition plate 18, optical partition plate 19, first installation area 110, second installation area 111

[0043] Routine blood test assembly 2, routine blood collection mechanism 21, routine blood test mechanism 22, first path X,

[0044] Protein detection integrated module 3, immune detection pool unit 31, transfer unit 32, reagent refrigeration warehouse 33, second path Y, straight line track Y1, circular arc track Y2, guide 34, positioning piece 35, reagent needle 36, integrated seat 37, base 371, frame body 372, installation part 373, cover body 38, premix pool 39, third path Z,

[0045] Swing block 301, first power device, gear set, second power device, top plate 3021, first linear guide rail 3022, sliding seat 3023, first motor 3024, fixed block 3031, driving gear 3032, rack 3033, vertical plate 3041, second linear guide rail 3042, second motor 3043,

[0046] Swing arm 3a, driving device 3b, circuit control assembly 3c,

[0047] reagent collection port 4,

[0048] reagent replacement port 5,

[0049] sample liquid collection port 6,

[0050] automatic sampling device 7. DETAILED DESCRIPTION

[0051] The embodiments of the present application will be described in detail with specific examples, and other advantages and effects of the present application can be easily understood by those skilled in the art from the disclosure. The present application can also be implemented or applied in other different embodiments, and various modifications or changes can be made to the details in the specification without departing from the spirit of the present application.

[0052] It should be understood that the present application can be implemented in different forms, and should not be interpreted as being limited to the embodiments presented herein. On the contrary, these embodiments are presented to make the disclosure complete and full, and to fully convey the scope of the present application to those skilled in the art.

[0053] The present application provides a sample analyzer, comprising a box body 1, a routine blood test assembly 2, a protein detection integrated module 3,

[0054] Please refer to the accompanying Figure 11 and Figure 12 As shown in some embodiments, the box body 1 is formed by a front plate 11 located at the front, a rear plate 12 located at the back, a left side plate 13 located at the left side, a right side plate 14 located at the right side, a top cover 15 located at the top, and a bottom plate 16 located at the bottom. An automatic sampling device 7 is arranged on the outside of the front plate 11 of the box body 1. The inside of the box body 1 is divided into multiple areas by multiple plate bodies. That is, the inside space of the box body 1 is divided into a left side bin and a right side bin by a longitudinally arranged partition plate 17. The left side bin is provided with a liquid path partition plate 18 parallel to the partition plate 17, which divides the left side bin into two bin bodies. A transversely arranged optical partition plate 19 is arranged in the right side bin close to the upper side, which divides the right side bin into an upper bin body and a lower bin body. The lower bin body includes a first mounting area 110 extending along a first path X direction and a second mounting area 111 located beside the first mounting area 110.

[0055] Please refer to the accompanying Figure 2 As shown in some embodiments, the routine blood test assembly 2 is arranged in the first mounting area 110 of the box body 1 and is used for collecting, distributing and detecting sample liquid. The routine blood test assembly 2 distributes sample liquid along the first path X. Please refer to the accompanying Figure 4 and Figure 5As shown, specifically, the blood routine detection component 2 includes a blood routine collection mechanism 21 for collecting and distributing sample liquid along the first path X and a blood routine detection mechanism 22 for receiving sample liquid for detection. The blood routine collection mechanism 21 is arranged along the front plate 11 to the back plate 12, and its collection and distribution path is the first path X. The blood routine collection mechanism 21 penetrates the front plate 11 and collects sample liquid from the automatic sampling device 7.

[0056] The blood routine detection mechanism 22 includes at least one reaction pool for completing blood routine detection. Multiple reaction pools are located at any position on the first path X where the blood routine collection mechanism 21 operates, and the sampling needle of the blood routine collection mechanism 22 distributes sample liquid along the first path X. Moreover, the circular arc trajectory movement of the reagent needle 36 does not interfere with the horizontal movement of the sampling needle.

[0057] Please refer to the accompanying drawings Figure 3 or Figure 7 or Figure 10 As shown, in some embodiments, the protein detection integrated module 3 includes at least a combination module of a reagent refrigeration bin 33, an immune detection pool unit 31, and a transfer unit 32. The transfer unit 32 transfers sample liquid and reagents of the reagent refrigeration bin 33 to the immune detection pool unit 31 along a second path Y. The reagent refrigeration bin 33 and the immune detection pool unit 31 are distributed on the second path Y, and the first path X intersects the second path Y. The protein detection integrated module 3 is detachably assembled and connected to the second mounting area 111 of the box body 1. The immune detection pool unit 31 includes at least two detection pools, a laser generating device, a signal detection device, and the like. The detection pools are used to receive sample liquid and latex reagents and complete immune reaction and specific protein detection in the detection pools. The reagent refrigeration bin 33 includes a bin body storing reagent bottles and a refrigeration unit, which provides a cold storage environment for the reagent bottles.

[0058] Please refer to the accompanying drawings Figure 1 or 6 or 8 and in combination with Figure 2 or 5 or 9, in some embodiments, the protein detection integrated module 3 is mounted or removed from the first side of the box body 1 along a third path direction. The second mounting area 111 is provided with multiple guide members 34 arranged along the third path direction and used for guiding and mounting the protein detection integrated module 3. The second mounting area 111 is also provided with multiple positioning members 35 used for limiting the mounting stroke of the protein detection integrated module 3.

[0059] It should be noted that in some embodiments, a premixing pool 39 is also provided. The premixing pool 39 is a reaction site for hemolysis before immune detection, i.e., receives blood sample liquid from the blood routine collection mechanism 21 and receives reagents from the liquid path unit, mixes and completes hemolysis and dilution of the sample liquid.

[0060] In the first embodiment, please refer to the attached Figure 1 and 2 As shown in Figs. 1 and 3, the protein detection integrated module 3 is detachably assembled with the box 1 as an independent module, wherein the reagent transfer between the reagent refrigeration bin 33 and the immune detection unit is linear motion, and the sample liquid transfer between the immune detection unit and the premixing pool 39 is realized by converting the linear motion into turning motion through the gear rack 3033. The specific implementation is as follows:

[0061] Please refer to the attached Figure 2 As shown in Fig. 3, the second path Y is a straight track Y1 and a circular track Y2; the circular track Y2 is connected with the straight track Y1 and intersects with the first path X. The transfer unit 32 includes a swing block 301 on which the reagent needle 36 is installed, a first power device for driving the swing block 301 to complete the straight track Y1 motion, and a gear set for driving the swing block 301 to complete the circular track Y2 motion; the transfer unit 32 is located above the reagent refrigeration bin 33 and the immune detection pool unit 31, so that the circuit is in the upper space and the liquid circuit is in the lower space, realizing liquid and electric separation. The reagent refrigeration bin 33 and the immune detection pool unit 31 are arranged along the straight track Y1, and the intersection area of the circular track Y2 and the first path X is provided with a premixing pool 39 for receiving and pre-treating the sample liquid from the routine blood detection assembly 2. The reagent needle 36 performs linear motion under the driving of the first power device, passes through the reagent refrigeration bin 33 and the immune detection pool unit 31, and transfers the reagent in the reagent refrigeration bin 33 to the immune detection pool unit 31. The reagent needle 36 performs circular swing through the gear set, passes through the premixing pool 39 and the immune detection unit, and transfers the sample liquid in the premixing pool 39 to the immune detection unit.

[0062] Based on the first embodiment, please refer to the attached Figure 2 As shown in Fig. 3, the straight track Y1 is parallel to the first path X, and the reagent refrigeration bin 33 and the immune detection pool unit 31 are arranged in a staggered manner with the routine blood detection assembly 2 in a direction perpendicular to the straight track Y1. The reagent refrigeration bin 33 and the immune detection pool unit 31 are arranged in a staggered manner with the routine blood detection assembly 2, so that the routine blood detection assembly 2 is not blocked by the protein detection integrated module 3, and the maintenance is convenient. Preferably, the reagent refrigeration bin 33 is closer to the front plate 11 than the immune detection pool unit 31, which is more convenient for reagent replacement and human-computer interaction operation.

[0063] Based on the first embodiment, please refer to the attached Figure 1 and 3As shown, the first power device includes a top plate 3021, a first linear guide rail 3022 arranged on the top plate 3021 along the linear track Y1, a sliding seat 3023 sliding back and forth along the first linear guide rail 3022, and a first motor 3024 driving the sliding seat 3023 to slide. The swing block 301 moves synchronously with the sliding seat 3023. The gear set includes a fixed block 3031, a driving gear 3032 rotatably arranged on the fixed block 3031, and a rack 3033. The fixed block 3031 moves synchronously with the sliding seat 3023. The rack 3033 is arranged on the linear track Y1 of the driving gear and located at the joint area of the linear track Y1 and the circular track Y2. The swing block 301 is installed on the driving gear 3032 and rotates synchronously. The outer end of the swing block 301 is installed with the reagent needle 36. After the driving gear 3032 passes through the immune detection pool unit 31, the reagent needle 36 continues to move, the driving gear 3032 starts to mesh with the rack 3033 to rotate, and the reagent needle 36 on the swing block 301 is rotated to the premixing pool 39.

[0064] Based on the first embodiment, please refer to the attached Figure 2 As shown, in order to further facilitate the positioning of the reagent needle 36 to absorb the reagent or sample liquid, the transfer unit 32 further includes a second power device driving the first power device to move up and down. The second power device includes a vertical plate 3041 installed on the sliding seat 3023, a second linear guide rail 3042 arranged on the vertical plate 3041, and a second motor 3043. The fixed block 3031 is slidingly arranged on the second linear guide rail 3042. The second motor drives the fixed block 3031, the driving gear 3032, and the swing block 301 to move up and down synchronously relative to the first power device. That is, when the reagent needle 36 is aligned with the reagent refrigeration bin 33, the immune detection pool unit 31, and the premixing pool 39, the second power device can drive the reagent needle 36 to move up and down to realize the extraction or release of the reagent or sample liquid.

[0065] In the second embodiment, please refer to the attached Figure 4 and 5 As shown in Figs. 6 and 7, based on the above-mentioned protein detection integrated module 3, the module can be detachably assembled with the box 1 as an independent module. The transfer of the reagent and the transfer of the sample liquid are both on a circular track Y2. The specific implementation is as follows:

[0066] Please refer to the attached Figure 5As shown, the second path Y is a continuous circular arc track Y2, the transfer unit 32 comprises a swing arm 3a on which the reagent needle 36 is mounted, a driving device 3b for driving the swing arm 3a to rotate, and a circuit control assembly 3c for controlling the reagent needle 36 to suck and discharge reagents. The outer end of the swing arm 3a is provided with a fixing portion for mounting the reagent needle 36, and the fixing portion is located above the immune detection cell unit 31 and the reagent refrigeration bin 33. Under the driving of the driving device 3b, the reagent needle 36 on the swing arm 3a swings to form the circular arc track Y2 and transfers reagents and / or sample liquid. In order to facilitate the integrated installation of the protein detection integrated module 3, the protein detection integrated module 3 further comprises an integrated seat 37, and the reagent refrigeration bin 33, the immune detection cell unit 31 and the transfer unit 32 are integrated and installed on the integrated seat 37. The protein detection integrated module 3 is detachably assembled to the second mounting area 111 of the box body 1 through the integrated seat 37.

[0067] Please refer to the accompanying drawings Figure 6 and 7 As shown, the driving device 3b and the circuit control assembly 3c are located below the swing arm 3a and are mounted on the integrated seat 37. A cover 38 is provided on the integrated seat 37, and the immune detection cell unit 31, the reagent refrigeration bin 33, the driving device 3b and the circuit control assembly 3c are located in the cover 38. The cover 38 is provided with reagent collection openings 4 corresponding to the immune detection cell unit 31 and the reagent refrigeration bin 33 for the reagent needle 36 to transfer reagents. The swing arm 3a is located outside the cover 38 and transfers reagents outside the cover 38. The cover 38 separates the reagent needle 36 from the circuit structure of the protein detection integrated module 3, preventing reagents or sample liquid from dropping into the circuit structure and achieving the protection of the circuit. The integrated seat 37 and the cover 38 are arranged outside the box body 1 and are provided with a reagent replacement opening 5. The reagent replacement opening 5 is directed to the front of the box body 1 and is used to push or pull out the reagents in the reagent refrigeration bin 33. Figure 5 As shown, the premixing pool 39 is located at the intersection of the first path X and the second path Y, and the cover 38 is provided with a sample liquid collection opening 6 corresponding to the premixing pool 39.

[0068] In the first and second specific embodiments, the specific protein immune detection process is as follows:

[0069] 1) Blood routine collection mechanism 21 dispenses sample liquid into premixing pool 39 through sampling needle, and adds hemolytic agent into premixing pool 39, realizes mixing and hemolysis in premixing pool 39, and completes hemolysis and dilution of sample liquid.

[0070] 2) After reagent needle 36 of transfer unit 32 moves to the position of reagent refrigeration warehouse 33, the latex reagent in the reagent bottle in reagent refrigeration warehouse 33 is quantitatively sucked by reagent needle 36 and is dispensed into detection pool A of immunodetection pool unit 31; it can be synchronized with step 1, and the detection period can be shortened; sampling needle and reagent needle 36 work at the same time, and when sampling or sample adding is performed at the intersection node of premixing pool, sampling needle and reagent needle can be controlled by spatially staggered movement or time sequence, and when time sequence control is required, only the time sequence of the first path movement needs to be staggered, and the detection speed is improved.

[0071] 3) Reagent needle 36 of transfer unit 32 sucks sample liquid A after hemolysis and dilution from premixing pool 39; and then is added to detection pool A to participate in reaction and detection.

[0072] 4) After the remaining sample liquid in premixing pool 39 is emptied, the cleaning reagent is provided by the cleaning device of the liquid path support unit to complete cleaning, and the cleaning of premixing pool 39 starts at any time after the sample liquid is sucked by reagent needle 36.

[0073] 5) After specific protein detection is completed, the detection waste liquid in detection pool A is emptied, and the cleaning reagent is provided by the cleaning device to complete cleaning.

[0074] 6) After the cleaning of premixing pool 39 is completed, sample liquid A can start the collection and hemolysis of the next sample, prepare sample liquid B and dispense it into detection pool B of immunodetection pool unit 31, and so on, and the two reaction pools are used alternately to improve the detection speed.

[0075] In the third specific embodiment: please combine the drawings shown in Figure 8 and 9 and 10, the above protein detection integrated module 3 is detachably assembled and connected with box body 1 as an independent module, wherein the transfer of reagent and sample liquid is on an arc trajectory Y2, and the specific implementation is as follows:

[0076] Please refer to the drawings shown in Figure 9As shown, the second path Y is a continuous circular arc trajectory Y2, the transfer unit 32 includes a swing arm 3a on which the reagent needle 36 is mounted, a driving device 3b that drives the swing arm 3a to rotate, and a circuit control assembly 3c that controls the reagent needle 36 to dispense reagents. The outer end of the swing arm 3a is provided with a fixing part for mounting the reagent needle 36, and the fixing part is located above the immunodetection cell unit 31 and the reagent refrigeration bin 33. Under the driving of the driving device 3b, the reagent needle 36 on the swing arm 3a swings to form the circular arc trajectory Y2 and transfers reagents and / or sample liquid.

[0077] Please refer to the accompanying drawings Figure 8 and 10 As shown, in order to facilitate the integrated installation of the protein detection integrated module 3, the protein detection integrated module 3 further includes an integrated seat 37, which includes a base 371 and a shelf 372 provided on the base 371. The protein detection integrated module 3 is detachably assembled and connected to the second mounting area 111 of the cabinet 1 through the integrated seat 37. The reagent refrigeration bin 33 and the immunodetection cell unit are arranged on the base 371 along the circular arc trajectory Y2. The shelf 372 extends upward and is provided with a mounting part at the upper space of the reagent refrigeration bin 33 and the immunodetection cell unit 31. The mounting part mounts the driving device 3b and the circuit control assembly 3c. The swing arm 3a of the transfer unit 32 is arranged below the driving device 3b. Different from the second specific embodiment, the driving device 3b and the circuit structure of the swing arm 3a are placed on the top, the circuit is in the upper space, and the liquid circuit is in the lower space, so as to realize liquid-electric separation.

[0078] Please refer to the accompanying drawings Figure 9 As shown, the intersection area of the first path X and the second path Y is provided with the immunodetection cell unit 31, or a premixing pool 39 is arranged at the intersection area of the first path X and the second path Y. Without the premixing pool 39, the sample liquid can be transferred again, but multiple protein detection cannot be performed. With the premixing pool 39, multiple protein detection can be performed, but the sample liquid needs to be transferred multiple times, and the timing of the reagent needle 36 and the sampling needle needs to be designed to be offset.

[0079] In the third specific embodiment, the specific protein immunodetection process is as follows:

[0080] 1) The blood routine collection mechanism 21 directly dispenses the sample liquid into the detection pool A of the immunodetection cell unit 31 through the sampling needle.

[0081] 2) After the reagent needle 36 of the transfer unit 32 moves to the position of the reagent refrigeration bin 33, the latex reagent in the reagent bottle in the reagent refrigeration bin 33 is quantitatively sucked by the reagent needle 36 and is distributed to the detection pool A of the immune detection pool unit 31; the step 1 can be synchronized, and the detection period can be shortened; the sampling needle and the reagent needle 36 work simultaneously, and when the sampling or sample adding is performed at the intersection of the immune detection pool unit, the sampling needle and the reagent needle can be controlled by spatially staggered movement or time sequence staggered movement; when the time sequence control is required, only the time sequence of the movement on the first path needs to be staggered, and the detection speed is improved.

[0082] 3) After the remaining sample liquid in the premixing pool 39 is emptied, the cleaning reagent is provided by the cleaning device of the liquid path support unit to complete cleaning, and the cleaning of the premixing pool 39 starts at any time after the sample liquid is sucked by the reagent needle 36.

[0083] 4) After the specific protein detection is completed, the detection waste liquid in the detection pool A is emptied, and the cleaning reagent is provided by the cleaning device to complete cleaning.

[0084] 5) The two detection pools of the immune detection pool unit 31 can be alternately used.

[0085] In summary:

[0086] 1) The sample instrument of the utility model is arranged on the blood routine sampling module movement path, only one premixing pool 39 or no premixing pool 39 is arranged, the length size of the instrument is reduced, the running track length of the sampling module is not increased due to the increase of test items, the length size of the instrument is not increased, the space in other directions of the whole machine can be effectively utilized, miniaturization is realized, and the space utilization rate of the instrument is high.

[0087] 2) The sample liquid A is diluted by the premixing pool 39, is transported to the specific protein detection pool A by the reagent transfer mechanism, the dilution ratio of the first hemolysis process is improved, the minimum distribution precision requirement of the blood routine collection mechanism 21 is reduced, the consumption of the latex reagent in the reagent bin is reduced, and the trace blood distribution precision can be avoided.

[0088] 3) The system is simplified, different kinds of specific protein detections with the same hemolysis process, such as CRP and SAA, can prepare one hemolysis sample liquid required for two immune reactions by the premixing pool 39 once, and different kinds of specific protein detections share one set of reaction pools, waste pipe and reagent supply device required for the hemolysis reaction.

[0089] 4) The protein detection integrated module 3 forms an independent specific protein detection system; if the part is removed, it is a blood routine model; if the part is added, it is a specific protein model; the switching and upgrading of the protein model can be realized.

[0090] 5. Good maintenance, protein detection integrated module 3 block and box 1 split, protein detection integrated module 3 block can be maintained, while the blood routine detection assembly 2 itself is all exposed, also convenient to maintain.

[0091] The above examples only illustrate the principles and effects of the present application, and are not used to limit the present application. Any person skilled in the art can modify or change the above examples without departing from the spirit and scope of the present application. Therefore, all equivalent modifications or changes made by those skilled in the art without departing from the spirit and technical concept disclosed by the present application should be covered by the claims of the present application.

Claims

1. A sample analyzer characterized by, The application relates to a blood routine test device, comprising: a box body, which comprises a first mounting area extending along a first path direction and a second mounting area located on the side of the first mounting area; a blood routine test assembly arranged in the first mounting area of the box body and used for collecting, distributing and testing sample liquid, wherein the blood routine test assembly distributes the sample liquid along the first path; a protein test integrated module, which comprises at least a combined module integrated by a reagent refrigeration bin, an immune test pool unit and a transfer unit; the transfer unit transfers the sample liquid and the reagent of the reagent refrigeration bin to the immune test pool unit along a second path; the reagent refrigeration bin and the immune test pool unit are distributed on the second path; and the first path intersects with the second path; the protein test integrated module is detachably assembled and connected to the second mounting area of the box body.

2. The sample analyzer of claim 1, wherein: the second path is a straight line track and a circular arc track; the circular arc track is connected with the straight line track and intersects with the first path; the transfer unit comprises a swing block provided with a reagent needle, a first power device for driving the swing block to complete the straight line track movement, and a gear set for driving the swing block to complete the circular arc track movement; the transfer unit is located above the reagent refrigeration bin and the immune test pool unit; the reagent refrigeration bin and the immune test pool unit are arranged along the straight line track; and a premixing pool for receiving and pretreating the sample liquid from the blood routine test assembly is arranged in the intersection area of the circular arc track and the first path.

3. The sample analyzer of claim 2, wherein: the straight line track is parallel to the first path; and the reagent refrigeration bin, the immune test pool unit and the blood routine test assembly are arranged in a staggered mode in a direction perpendicular to the straight line track.

4. The sample analyzer of claim 2, wherein: the first power device comprises a top plate, a first straight line guide rail arranged on the top plate and along the straight line track, a sliding seat sliding back and forth along the first straight line guide rail, and a first motor for driving the sliding seat to slide; and the swing block moves synchronously with the sliding seat.

5. The sample analyzer of claim 4, wherein: the gear set comprises a fixed block, a driving gear rotatingly arranged on the fixed block and a rack; the fixed block moves synchronously with the sliding seat; the rack is arranged on the straight line track of the driving gear and located in the connection area of the straight line track and the circular arc track; the swing block is mounted on the driving gear and rotates synchronously; and the outer end of the swing block is provided with the reagent needle; after the reagent needle moves from the reagent refrigeration bin to the immune test pool unit, the reagent needle continues to move, the driving gear starts to mesh with the rack and rotates, and the reagent needle on the swing block is transferred to the premixing pool.

6. The sample analyzer of claim 5, wherein: the transfer unit further comprises a second power device for driving the first power device to move up and down; the second power device comprises a vertical plate mounted on the sliding seat, a second straight line guide rail and a second motor arranged on the vertical plate; the fixed block is slidingly arranged on the second straight line guide rail; and the second motor drives the fixed block, the driving gear and the swing block to move up and down synchronously relative to the first power device.

7. The sample analyzer of claim 1, wherein: The second path is a continuous circular arc track, the transfer unit comprises a swing arm for mounting a reagent needle, a driving device for driving the swing arm to rotate, and a circuit control assembly for controlling the reagent needle to draw and discharge reagents, an outer end of the swing arm is provided with a fixing portion for mounting the reagent needle, the fixing portion is located above the immunodetection cell unit and the reagent refrigeration bin, under the driving of the driving device, the reagent needle on the swing arm swings to form the circular arc track and transfer reagents and / or sample liquid.

8. The sample analyzer of claim 7, wherein: The protein detection integrated module further comprises an integrated seat, the reagent refrigeration bin, the immunodetection cell unit and the transfer unit are integrally mounted on the integrated seat, and the protein detection integrated module is detachably assembled to the second mounting area of the box body through the integrated seat.

9. The sample analyzer of claim 8, wherein: The driving device and the circuit control assembly are located below the swing arm and are mounted on the integrated seat, a cover body is arranged on the integrated seat, the immunodetection cell unit, the reagent refrigeration bin, the driving device and the circuit control assembly are located in the cover body, the cover body is provided with reagent collection openings corresponding to the immunodetection cell unit and the reagent refrigeration bin respectively for the reagent needle to transfer reagents, and the swing arm is arranged outside the cover body and transfers reagents outside the cover body.

10. The sample analyzer of claim 9, wherein: The integrated seat and the cover body are arranged to pass through the side of the box body and are provided with reagent replacement openings, the reagent replacement openings are directed to the front of the box body, and the reagent in the reagent refrigeration bin is pushed or drawn out along the direction.

11. The sample analyzer of claim 10, wherein: The protein detection integrated module further comprises a premixing pool for receiving and pre-treating sample liquid from the blood routine detection assembly, the premixing pool is integrally mounted on the integrated seat together with the reagent refrigeration bin, the immunodetection cell unit and the transfer unit and is located in the cover body, the premixing pool is located at the intersection of the first path and the second path, and the cover body is provided with a sample liquid collection opening corresponding to the premixing pool.

12. The sample analyzer of claim 7, wherein: The protein detection integrated module further comprises an integrated seat, the integrated seat comprises a base and a frame arranged on the base, the reagent refrigeration bin and the immunodetection unit are arranged on the base and are arranged along the circular arc track, the frame extends upward and is provided with a mounting portion at the upper space of the reagent refrigeration bin and the immunodetection cell unit, the mounting portion mounts the driving device and the circuit control assembly, and the swing arm of the transfer unit is arranged below the driving device.

13. The sample analyzer of claim 12, wherein: The immunodetection cell unit is located at the intersection area of the first path and the second path.

14. The sample analyzer of claim 1, wherein: The protein detection integrated module is mounted or removed from the first side of the box body along a third path direction, the second mounting area is provided with a plurality of guide members arranged along the third path direction and used for guiding and mounting the protein detection integrated module, and a plurality of positioning members are further arranged on the second mounting area and used for limiting the mounting stroke of the protein detection integrated module.

15. The sample analyzer of claim 2 or 7, wherein: The blood routine detection assembly comprises a blood routine collection mechanism for collecting and distributing sample liquid and at least two blood routine detection mechanisms for receiving sample liquid for detection, and a sampling needle of the blood routine collection mechanism distributes sample liquid along the first path.

16. The sample analyzer of claim 15, wherein: The circular arc track movement of the reagent needle does not interfere with the horizontal movement of the sampling needle.

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