Mirabegron production device

Abstract

The utility model discloses a mirabegron production device which comprises a main body unit, the main body unit comprises a reaction kettle and a processing box, the processing box is arranged at the right end of the reaction kettle, a rectangular box is arranged on the reaction kettle, a connecting block is fixedly connected to the side wall of the processing box, and a material pumping assembly is arranged between the reaction kettle and the processing box. Liquid medicine in the extraction crystallization tank body is heated, extracted and crystallized by starting the heating plate, the electric telescopic rod is started, the telescopic end of the electric telescopic rod drives the rectangular plate and the vertical rod to move downwards, the vertical rod extends into the extraction crystallization tank body, the gear motor is started, the output end of the gear motor drives the threaded rod, and the threaded rod is driven to rotate. A threaded rod drives an arc-shaped plate, an electric telescopic rod, a rectangular plate and a vertical rod to move through a threaded sleeve and a movable rod, the vertical rod can stir liquid medicine in the extraction crystallization tank body, heating extraction crystallization of a heating plate on the liquid medicine is accelerated, and the extraction crystallization efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of chemical production equipment technology, and in particular to a Miraberon production apparatus. Background Technology

[0002] Mirabelon, developed by Astellas Pharma Europe BV, is a novel, highly selective β3 receptor agonist that relieves symptoms such as urinary frequency, urgency, and incontinence by selectively acting on bladder smooth muscle. It has advantages such as a unique therapeutic mechanism, good efficacy and safety, and a low adverse reaction rate, and its market prospects are promising.

[0003] The production of mirabezone requires the extraction and crystallization of crude mirabezone using a specific mixed solvent to obtain a high-purity product. However, current methods rely solely on heating to accelerate this process, which is not only time-consuming but also relatively inefficient. Utility Model Content

[0004] The purpose of this section is to outline some aspects of embodiments of the present invention and to briefly describe some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of this application, to avoid obscuring the purpose of these documents; however, such simplifications or omissions should not be construed as limiting the scope of the present invention.

[0005] Therefore, the purpose of this invention is to provide a device for the production of Miraberon, which addresses the problem that "in the production process of Miraberon, it is necessary to use a specific mixed solvent to extract and crystallize the crude Miraberon to obtain a high-purity product. However, current methods rely solely on heating to accelerate this process, which is not only time-consuming but also relatively inefficient."

[0006] To solve the above-mentioned technical problems, this utility model provides the following technical solution:

[0007] An apparatus for producing Mirabellon includes:

[0008] The main unit includes a reaction vessel and a processing box. The processing box is located at the right end of the reaction vessel. A rectangular box is installed on the reaction vessel. A connecting block is fixedly connected to the side wall of the processing box. A material extraction assembly is installed between the reaction vessel and the processing box.

[0009] The working unit includes a stirring assembly, an extraction and crystallization tank, and a feeding hopper. The stirring assembly is located in a reaction vessel, and the extraction and crystallization tank is located in a processing box. A heating plate is located at the lower end of the extraction and crystallization tank and is fixedly installed on the inner wall of the processing box. The feeding hopper is fixedly installed on the inner wall of the reaction vessel and is equipped with a solenoid valve. A connecting block has a connecting cavity, and a geared motor is fixedly installed on the side wall of the connecting block. The output end of the geared motor passes through the side wall of the connecting block and is fixedly connected to a threaded rod. The threaded rod is threadedly fitted with a threaded sleeve. A sliding opening is provided on both the side wall of the connecting block and the side wall of the processing box. The threaded sleeve passes through the sliding opening and is fixedly connected to a moving rod. An arc-shaped plate is fixedly connected to the end of the moving rod away from the threaded sleeve. The arc-shaped plate is slidably connected to the inner wall of the processing box. Two electric telescopic rods are symmetrically fixedly installed on the arc-shaped plate. The extension and retraction of the two electric telescopic rods are jointly fixedly connected to a rectangular plate, and each rectangular plate is provided with multiple vertical rods.

[0010] As a preferred embodiment of the Mirabell production apparatus of this utility model, the stirring assembly includes a servo motor, which is fixedly installed on the upper surface of the reactor. The output end of the servo motor passes through the upper surface of the reactor and is fixedly connected to a rotating rod. Two connecting sleeves are fixedly sleeved on the rotating rod. Multiple connecting rods are symmetrically fixedly connected to each connecting sleeve. A stirring plate is fixedly connected to the end of each connecting rod away from the connecting sleeve.

[0011] As a preferred embodiment of the Mirabell production apparatus described in this utility model, the material extraction assembly includes a booster pump, which is fixedly installed on the upper surface of the processing box. The input end of the booster pump is fixedly connected to a first connecting pipe, the end of the first connecting pipe opposite to the booster pump penetrates the side wall of the reactor, and the output end of the booster pump is fixedly connected to a second connecting pipe. The end of the second connecting pipe opposite to the booster pump penetrates the upper surface of the processing box and is fixedly connected to a discharge hopper.

[0012] As a preferred embodiment of the Mirabell production apparatus described in this utility model, the rectangular box has a circular opening, the reactor passes through the circular opening, the rectangular box has a first through-hole, the lower end of the feed hopper is provided with a square plate, the square plate has a circular opening, a circular filter plate is installed in the circular opening, two first insertion ports are symmetrically provided on the inner wall of the first through-hole, each first insertion port is provided with a first insertion rod, each first insertion rod is fixedly connected to the square plate, the square plate is fixedly connected to a first connecting plate, and a first handle is fixedly connected to the first connecting plate.

[0013] As a preferred embodiment of the Mirabell production apparatus of this utility model, the processing box has two mounting blocks symmetrically fixedly connected to its inner wall. Each mounting block has a second insertion port symmetrically provided, and each second insertion port is provided with a second insertion rod. Each second insertion rod is fixedly connected to the extraction crystallization tank. The processing box has a second through-hole. The extraction crystallization tank is fixedly connected to a second connecting plate, and a second handle is fixedly connected to the second connecting plate.

[0014] As a preferred embodiment of the Mirabell production apparatus of this utility model, the upper end of the reactor is symmetrically and fixedly connected to two feed inlets, the side wall of the processing box is fixedly connected to a control board with control buttons, the lower end of the reactor is symmetrically and fixedly connected to four support legs, the lower end of the processing box is symmetrically and fixedly connected to two support plates, the side wall of the processing box is provided with an installation port, an installation plate is fixedly installed in the installation port, and the installation plate is provided with multiple vent holes.

[0015] The beneficial effects of this utility model are:

[0016] The raw materials are mixed evenly by the stirring assembly to accelerate the reaction. The solenoid valve is activated, and the reacted liquid flows from the top to the bottom of the reactor. The suction assembly then draws the liquid from the bottom into the processing tank, where it falls into the extraction and crystallization tank. The heating plate is activated to heat and crystallize the liquid in the tank. The electric telescopic rod is activated, its extension end moving the rectangular plate and vertical rod downwards into the extraction and crystallization tank. The geared motor is activated, its output driving a threaded rod. This threaded rod, through a threaded sleeve and a moving rod, moves the arc-shaped plate, the electric telescopic rod, the rectangular plate, and the vertical rod. The vertical rod agitates the liquid in the extraction and crystallization tank, accelerating the heating and crystallization process and improving efficiency. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Among them:

[0018] Figure 1 This is a schematic diagram of the overall structure of a Miraberon production device proposed in this utility model;

[0019] Figure 2 This is a cross-sectional structural diagram of a Mirabell production apparatus proposed in this utility model;

[0020] Figure 3 This is a cross-sectional structural diagram of a connecting block used in a Mirabell production apparatus according to the present invention.

[0021] In the diagram: 100, Main unit; 101, Reactor; 102, Processing box; 103, Rectangular box; 104, Connecting block; 105, Material extraction assembly; 105a, Booster pump; 105b, Connecting pipe No. 1; 105c, Connecting pipe No. 2; 105d, Discharge hopper; 106, Connecting plate No. 1; 107, Connecting plate No. 2; 108, Control panel; 109, Feed inlet; 110, Support leg; 111, Support plate; 112, Mounting plate;

[0022] 200. Working unit; 201. Stirring assembly; 201a. Servo motor; 201b. Rotating rod; 201c. Connecting sleeve; 201d. Connecting rod; 201e. Stirring plate; 202. Extraction crystallization tank; 203. Heating plate; 204. Gear motor; 205. Threaded rod; 206. Threaded sleeve; 207. Moving rod; 208. Arc plate; 209. Electric telescopic rod; 210. Rectangular plate; 211. Vertical rod; 212. Square plate; 213. Circular filter plate; 214. Insertion rod No. 1; 215. Insertion rod No. 2; 216. Mounting block; 217. Feed hopper. Detailed Implementation

[0023] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings.

[0024] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art can make similar extensions without departing from the spirit of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0025] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that excludes other embodiments.

[0026] Secondly, this utility model is described in detail with reference to the schematic diagrams. When describing the embodiments of this utility model, for ease of explanation, the cross-sectional views illustrating the device structure may be partially enlarged, not adhering to the usual scale. Furthermore, the schematic diagrams are merely examples and should not limit the scope of protection of this utility model. In addition, actual manufacturing should include the three-dimensional spatial dimensions of length, width, and depth.

[0027] Reference Figure 1-3 This utility model provides a Miraberon production apparatus, comprising:

[0028] The main unit 100 includes a reactor 101 and a processing box 102. The processing box 102 is located at the right end of the reactor 101. A rectangular box 103 is provided on the reactor 101. A connecting block 104 is fixedly connected to the side wall of the processing box 102. A material extraction assembly 105 is provided between the reactor 101 and the processing box 102.

[0029] The working unit 200 includes a stirring assembly 201, an extraction crystallization tank 202, and a feeding hopper 217. The stirring assembly 201 is disposed in the reactor 101, and the extraction crystallization tank 202 is disposed in the processing box 102. A heating plate 203 is disposed at the lower end of the extraction crystallization tank 202 and is fixedly installed on the inner wall of the processing box 102. The feeding hopper 217 is fixedly installed on the inner wall of the reactor 101 and is equipped with a solenoid valve. A connecting block 104 has a connecting cavity, and a geared motor 204 is fixedly installed on the side wall of the connecting block 104. The output end of the geared motor 204 passes through the side wall of the connecting block 104 and is fixedly connected to a threaded rod 205. A threaded sleeve 206 is threaded onto the threaded rod 205. A sliding opening is provided on both the side wall of the connecting block 104 and the side wall of the processing box 102. A moving rod 207 is fixedly connected to the threaded sleeve 206 through the sliding opening. An arc-shaped plate 208 is fixedly connected to the end of the moving rod 207 facing away from the threaded sleeve 206. The arc-shaped plate 208 is slidably connected to the inner wall of the processing box 102. Two electric telescopic rods 209 are symmetrically fixedly installed on the arc-shaped plate 208. The telescopic joint of 9 is fixedly connected to a rectangular plate 210. Each rectangular plate 210 is equipped with multiple vertical rods 211. The raw materials are mixed and stirred evenly by the stirring assembly 201 to accelerate the reaction. The solenoid valve is activated, and the reacted liquid flows from the upper end of the reaction vessel 101 to the lower end. The liquid is then drawn from the lower end of the reaction vessel 101 into the processing box 102 by the material extraction assembly 105. The liquid falls into the extraction and crystallization tank 202. The heating plate 203 is activated to heat and extract the liquid in the extraction and crystallization tank 202. The electric telescopic joint is activated. The telescopic rod 209, at its telescopic end, drives the rectangular plate 210 and the vertical rod 211 downwards. The vertical rod 211 extends into the extraction crystallization tank 202. The reduction motor 204 is activated, and its output end drives the threaded rod 205. The threaded rod 205, through the threaded sleeve 206 and the moving rod 207, drives the arc plate 208, the electric telescopic rod 209, the rectangular plate 210, and the vertical rod 211 to move. The vertical rod 211 can stir the medicinal liquid in the extraction crystallization tank 202, accelerate the heating and extraction crystallization of the medicinal liquid by the heating plate 203, and improve the extraction crystallization efficiency.

[0030] The stirring assembly 201 includes a servo motor 201a, which is fixedly mounted on the upper surface of the reactor 101. The output end of the servo motor 201a passes through the upper surface of the reactor 101 and is fixedly connected to a rotating rod 201b. Two connecting sleeves 201c are fixedly sleeved on the rotating rod 201b. Each connecting sleeve 201c is symmetrically fixedly connected to multiple connecting rods 201d. Each connecting rod 201d is fixedly connected to a stirring plate 201e at the end opposite to the connecting sleeve 201c. When the servo motor 201a is started, the output end of the servo motor 201a drives the rotating rod 201b to rotate. The rotating rod 201b drives the stirring plate 201e to rotate through the connecting sleeves 201c and the connecting rods 201d. The stirring plate 201e mixes and stirs the raw materials evenly, accelerating the reaction of the raw materials.

[0031] Furthermore, the material extraction assembly 105 includes a booster pump 105a, which is fixedly installed on the upper surface of the processing tank 102. The input end of the booster pump 105a is fixedly connected to a first connecting pipe 105b. One end of the first connecting pipe 105b, away from the booster pump 105a, penetrates through the side wall of the reactor 101. The output end of the booster pump 105a is fixedly connected to a second connecting pipe 105c. One end of the second connecting pipe 105c, away from the booster pump 105a, penetrates through the upper surface of the processing tank 102 and is fixedly connected to a discharge hopper 105d. When the booster pump 105a is started, the booster pump 105a extracts the liquid from the lower end of the reactor 101 through the first connecting pipe 105b. The liquid enters the processing tank 102 through the first connecting pipe 105b and the discharge hopper 105d, and falls into the extraction crystallization tank 202.

[0032] Furthermore, the rectangular box 103 has a circular opening, through which the reactor 101 passes. A first opening is provided on the rectangular box 103. A square plate 212 is provided at the lower end of the feed hopper 217. A circular opening is provided on the square plate 212, and a circular filter plate 213 is installed in the circular opening. Two first insertion ports are symmetrically provided on the inner wall of the first opening. A first insertion rod 214 is provided in each first insertion port. Each first insertion rod 214 is fixedly connected to the square plate 212. A first connecting plate 106 is fixedly connected to the square plate 212. A first handle is fixedly connected to the first connecting plate 106. The first connecting plate 106, the square plate 212, and the circular filter plate 213 can be removed through the first handle.

[0033] Furthermore, two mounting blocks 216 are symmetrically fixedly connected to the inner wall of the processing box 102. Each mounting block 216 is symmetrically provided with a second insertion port. Each second insertion port is provided with a second insertion rod 215. Each second insertion rod 215 is fixedly connected to the extraction crystallization tank 202. The processing box 102 is provided with a second through port. The extraction crystallization tank 202 is fixedly connected with a second connecting plate 107. A second handle is fixedly connected to the second connecting plate 107. By using the second handle to remove the second connecting plate 107 and the crystallization tank 202, the crystallized Miraberon crystals can be removed.

[0034] Furthermore, the upper end of the reactor 101 is symmetrically and fixedly connected to two feed ports 109, and the side wall of the processing box 102 is fixedly connected to a control board 108, which is equipped with control buttons. The lower end of the reactor 101 is symmetrically and fixedly connected to four support legs 110, and the lower end of the processing box 102 is symmetrically and fixedly connected to two support plates 111. The side wall of the processing box 102 is provided with an installation port, in which an installation plate 112 is fixedly installed. The installation plate 112 is provided with multiple vent holes. Raw materials are added to the reactor 101 through the feed ports 109, and the electrical components can be started and stopped by the control buttons on the control board 108.

[0035] During operation, the raw materials are added to the reactor 101 through the feed inlet 109. The servo motor 201a is started, and its output drives the rotating rod 201b to rotate. The rotating rod 201b drives the stirring plate 201e to rotate through the connecting sleeve 201c and the connecting rod 201d. The stirring plate 201e mixes and stirs the raw materials evenly, accelerating the reaction. The solenoid valve is activated, and the reacted liquid flows from the upper end of the reactor 101 to the lower end. During the flow, the liquid passes through the circular filter plate 213, which filters out the residue in the liquid. The booster pump 105a is started, and it draws the liquid from the lower end of the reactor 101 through the first connecting pipe 105b. The liquid then flows through the first connecting pipe 105b and the discharge hopper 105d into the reactor. The medicinal liquid falls into the extraction and crystallization tank 202 after entering the processing box 102. The heating plate 203 is activated, which heats and extracts the medicinal liquid in the extraction and crystallization tank 202. The electric telescopic rod 209 is activated, and its telescopic end drives the rectangular plate 210 and the vertical rod 211 to move downward. The vertical rod 211 extends into the extraction and crystallization tank 202. The reduction motor 204 is activated, and its output end drives the threaded rod 205. The threaded rod 205 moves the arc plate 208, the electric telescopic rod 209, the rectangular plate 210, and the vertical rod 211 through the threaded sleeve 206 and the moving rod 207. The vertical rod 211 can stir the medicinal liquid in the extraction and crystallization tank 202, accelerate the heating and extraction of the medicinal liquid by the heating plate 203, and improve the extraction and crystallization efficiency.

[0036] It should be noted that the above embodiments are only used to illustrate the technical solution of this utility model and are not intended to limit it. Although this utility model has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications or substitutions should be covered within the scope of the claims of this utility model.

Claims

1. A device for mirabegron production, characterized by: Include: The main unit (100) includes a reaction kettle (101) and a processing box (102), the processing box (102) is arranged at the right end of the reaction kettle (101), a rectangular box (103) is arranged on the reaction kettle (101), a connecting block (104) is fixedly connected on the side wall of the processing box (102), and a material extraction assembly (105) is arranged between the reaction kettle (101) and the processing box (102); The working unit (200) includes a stirring assembly (201), an extraction crystallization tank body (202) and a material passing hopper (217), the stirring assembly (201) is arranged in the reaction kettle (101), the extraction crystallization tank body (202) is arranged in the processing box (102), a heating plate (203) is arranged at the lower end of the extraction crystallization tank body (202), the heating plate (203) is fixedly installed on the inner wall of the processing box (102), the material passing hopper (217) is fixedly installed on the inner wall of the reaction kettle (101), an electromagnetic valve is arranged on the material passing hopper (217), a connecting cavity is formed in the connecting block (104), a reduction motor (204) is fixedly installed on the side wall of the connecting block (104), the output end of the reduction motor (204) penetrates the side wall of the connecting block (104) and is fixedly connected with a threaded rod (205), the threaded rod (205) is threadedly sleeved with a threaded sleeve (206), a sliding opening is formed in the side wall of the connecting block (104) and the side wall of the processing box (102), the threaded sleeve (206) penetrates the sliding opening and is fixedly connected with a moving rod (207), one end of the moving rod (207) away from the threaded sleeve (206) is fixedly connected with an arc plate (208), the arc plate (208) is slidingly connected to the inner wall of the processing box (102), two electric telescopic rods (209) are fixedly installed on the arc plate (208) in a symmetrical manner, and the extensions of the two electric telescopic rods (209) are fixedly connected with a rectangular plate (210), a plurality of vertical rods (211) are arranged on each rectangular plate (210).

2. A device for mirabegron production according to claim 1, characterized in that: The stirring assembly (201) includes a servo motor (201a), the servo motor (201a) is fixedly installed on the upper end face of the reaction kettle (101), the output end of the servo motor (201a) penetrates the upper end face of the reaction kettle (101) and is fixedly connected with a rotating rod (201b), two connecting sleeves (201c) are fixedly sleeved on the rotating rod (201b), a plurality of connecting rods (201d) are fixedly connected to each connecting sleeve (201c) in a symmetrical manner, and a stirring plate (201e) is fixedly connected to one end of each connecting rod (201d) away from the connecting sleeve (201c).

3. A device for mirabegron production according to claim 1, characterized in that: The extraction assembly (105) includes a booster pump (105a) fixedly installed on the upper end face of the processing box (102), the input end of the booster pump (105a) is fixedly connected with a first connecting pipe (105b), one end of the first connecting pipe (105b) away from the booster pump (105a) penetrates the side wall of the reaction kettle (101), and the output end of the booster pump (105a) is fixedly connected with a second connecting pipe (105c), one end of the second connecting pipe (105c) away from the booster pump (105a) penetrates the upper end face of the processing box (102) and is fixedly connected with a discharge hopper (105d).

4. A device for mirabegron production according to claim 1, characterized in that: The rectangular box (103) is provided with a round opening, the reaction kettle (101) penetrates the round opening, and the rectangular box (103) is provided with a first through opening. The lower end of the material feeding hopper (217) is provided with a square plate (212), the square plate (212) is provided with a circular opening, the circular opening is provided with a circular filter plate (213), and the inner wall of the first through opening is symmetrically provided with two first insertion openings. Each first insertion opening is provided with a first insertion rod (214), and each first insertion rod (214) is fixedly connected to the square plate (212). The square plate (212) is fixedly connected with a first connecting plate (106), and the first connecting plate (106) is fixedly connected with a first handle.

5. A device for mirabegron production according to claim 1, characterized in that: The inner wall of the processing box (102) is symmetrically fixedly connected with two mounting blocks (216), each mounting block (216) is symmetrically provided with a second insertion opening, each second insertion opening is provided with a second insertion rod (215), and each second insertion rod (215) is fixedly connected to the extraction crystallization tank body (202). The processing box (102) is provided with a second through opening, the extraction crystallization tank body (202) is fixedly connected with a second connecting plate (107), and the second connecting plate (107) is fixedly connected with a second handle.

6. A device for mirabegron production according to claim 1, characterized in that: The upper end face of the reaction kettle (101) is symmetrically fixedly connected with two feeding openings (109), the side wall of the processing box (102) is fixedly connected with a control panel (108), the control panel (108) is provided with a control button, the lower end face of the reaction kettle (101) is symmetrically fixedly connected with four supporting legs (110), the lower end face of the processing box (102) is symmetrically fixedly connected with two supporting plates (111), the side wall of the processing box (102) is provided with a mounting opening, the mounting opening is fixedly installed with a mounting plate (112), and the mounting plate (112) is provided with a plurality of ventilation holes.

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