Reagent preparation equipment adaptive to full-automatic workstation for biological medicine research

Abstract

When the reagent preparation equipment adaptive to the full-automatic workstation for biological medicine research is used, the test tube rack is used for storing screw tubes at normal temperature, the low-temperature storage rack is used for refrigerating and storing the screw tubes, and the cap screwing mechanism can move transversely, longitudinally and vertically through the transverse moving mechanism, the longitudinal moving mechanism and the vertical moving mechanism respectively; the screw tube can be moved to any proper position, the screw tube can be sleeved, transferred and withdrawn through the cap screwing mechanism, the screw tube can be clamped through the clamping mechanism, cap opening and closing of the screw tube can be achieved through the cap screwing mechanism in the screw tube clamping state, and liquid in the screw tube can be evenly mixed through the centrifugal mixing mechanism. The automatic reagent preparation device is matched with a pipettor module to realize automatic preparation of a reagent, so that the automatic reagent preparation device can be adapted to a full-automatic workstation for biological medicine research to promote the application of full-automatic experimental equipment for biological medicine research.

Description

Technical Field

[0001] This utility model relates to the field of biomedical research technology, and particularly to the field of fully automated workstations for biomedical research, specifically referring to a reagent preparation device adapted to a fully automated workstation for biomedical research. Background Technology

[0002] Biomedical research refers to the application of theories and methods from disciplines such as biology, medicine, and biotechnology to conduct research related to new drug development, disease diagnosis, prevention, and treatment. The core of biomedical research is the integration of modern biotechnology with new drug development and production, aiming to improve medical standards and human health.

[0003] In biomedical research, reagent preparation is an essential experimental step. Typical reagent preparation steps include: unscrewing the caps of the raw material reagent tubes stored on the reagent rack; if the raw material reagent tubes require refrigeration, opening the refrigerator, removing the raw material reagent tubes, and unscrewing the caps; placing the preparation reagent tube on the reagent rack and unscrewing the cap; taking different amounts of various raw materials and reagents from multiple raw material reagent tubes and transferring them to the preparation reagent tube as needed; screwing the cap back on the preparation reagent tube; mixing the various raw materials and reagents in the preparation reagent tube to prepare the experimental reagent; and finally transferring the preparation reagent tube to a room temperature storage area or a refrigerated storage area.

[0004] Because reagent preparation involves numerous steps and has a low throughput, currently available fully automated laboratory platforms do not have dedicated reagent preparation functions. This prevents current fully automated laboratory equipment from achieving true unmanned operation, significantly limiting its application in biomedical research.

[0005] Therefore, it is hoped that a reagent preparation device adapted to fully automated workstations in biomedical research can be developed. This device, in conjunction with a pipette module, can achieve automated reagent preparation, thus making it compatible with fully automated workstations in biomedical research and promoting the application of fully automated experimental equipment in biomedical research. Utility Model Content

[0006] In order to overcome the shortcomings of the prior art, one objective of this utility model is to provide a reagent preparation device adapted to a fully automated workstation for biomedical research. This device, in conjunction with a pipette module, can realize the automated preparation of reagents, thereby adapting to a fully automated workstation for biomedical research, promoting the application of fully automated experimental equipment in biomedical research, and is suitable for large-scale promotion and application.

[0007] Another objective of this invention is to provide a reagent preparation device adapted to a fully automated workstation for biomedical research. It is ingeniously designed, has a simple structure, is easy to manufacture, has low manufacturing costs, and is suitable for large-scale promotion and application.

[0008] To achieve the above objectives, this utility model provides a reagent preparation device adapted to a fully automated workstation for biomedical research. Its features include a horizontal moving mechanism, a vertical moving mechanism, a capping mechanism, a base plate, a clamping mechanism, a centrifugal mixing mechanism, a test tube rack, and a low-temperature storage rack, wherein:

[0009] The lateral movement mechanism includes a lateral movement support frame, a front lateral movement guide rail, a rear lateral movement guide rail, a lateral movement slide, and a lateral movement drive device. The lateral movement support frame is horizontally arranged along the left-right direction. The front and rear lateral movement guide rails are both horizontally arranged along the left-right direction and are spaced apart from each other on the lateral movement support frame. The lateral movement slide is vertically arranged along the front-back direction and located in the lateral movement support frame. The front and rear ends of the lateral movement slide are movably arranged left and right on the front and rear lateral movement guide rails, respectively. The lateral movement drive device is mounted on the lateral movement support frame and connected to the lateral movement slide to drive the lateral movement slide to move left and right.

[0010] The longitudinal moving mechanism includes a longitudinal moving slide, a longitudinal moving guide rail, and a longitudinal moving drive device. The longitudinal moving guide rail is vertically arranged along the front-back direction and located in the transverse moving support frame. The longitudinal moving guide rail is located to the left of the transverse moving slide and connected to the transverse moving slide. The longitudinal moving slide is vertically arranged along the front-back direction and located in the transverse moving support frame. The longitudinal moving slide is located to the left of the longitudinal moving guide rail and is movably connected to the longitudinal moving guide rail. The longitudinal moving drive device is installed on the transverse moving slide and connected to the longitudinal moving slide for driving the longitudinal moving slide to move back and forth.

[0011] The vertical moving mechanism includes a vertical moving fixed base, a vertical moving guide rail, and a vertical moving drive device. The vertical moving fixed base is located in the horizontal moving support frame and is located to the left of the longitudinal moving slide and connected to the longitudinal moving slide. The vertical moving guide rail is vertically arranged and vertically movably arranged in the vertical moving fixed base. The vertical moving drive device is installed on the vertical moving fixed base and connected to the vertical moving guide rail for driving the vertical moving guide rail to move up and down.

[0012] The capping mechanism includes a capping fixing seat, a capping shaft, a capping head, a rotary drive device, a tube ejection push rod, and a push rod drive device. The capping fixing seat is located below the vertically movable fixing seat and connected to the vertically movable guide rail. The capping shaft is vertically arranged and located to the left of the capping fixing seat, and is horizontally rotatably connected to the capping fixing seat. The capping head is horizontally arranged and downwardly positioned for fitting onto the cap of the threaded tube. The capping head is located below the capping shaft and connected to the capping shaft. The rotary drive device is installed on the capping fixing seat and connected to the capping shaft to drive the capping shaft to rotate horizontally. The capping shaft is vertically hollow. The tube ejection push rod is vertically arranged and vertically movably inserted into the capping shaft. The upper end of the tube ejection push rod protrudes upward from the capping shaft. The push rod drive device is installed on the capping fixing seat and connected to the upper end of the tube ejection push rod to drive the tube ejection push rod to move vertically.

[0013] The base plate is horizontally arranged and along the front-back direction, and the base plate is located in the transverse moving support frame and below the capping mechanism;

[0014] The clamping mechanism includes a clamping base, a clamping movable block, a clamping fixed block, and a clamping drive device. The clamping base is vertically arranged and positioned on the base plate along the left-right direction. The clamping movable block and the clamping fixed block are both vertically arranged and positioned along the front-back direction, and are spaced apart from each other on the left and right. The clamping fixed block is positioned on the clamping base. The clamping movable block is movably positioned on the clamping base. The clamping drive device is mounted on the clamping base and connected to the clamping movable block to drive the clamping movable block to move left and right. The number of clamping mechanisms is two.

[0015] The centrifugal mixing mechanism includes a front support frame, a rear support frame, a centrifugal mixing assembly, and a rotating assembly. Both the front and rear support frames are vertically arranged and positioned laterally on the base plate. The centrifugal mixing assembly includes a centrifugal fixing seat, a rotating shaft fixing seat, a rotating shaft, a centrifugal drive device, and a rotor. The centrifugal fixing seat is located between the front and rear support frames and rotatably connects them in the front-rear direction. The rotating shaft fixing seat is mounted on the centrifugal fixing seat, and the rotating shaft is vertically arranged... The rotating shaft is vertically inserted through the middle of the rotating shaft fixing seat and is horizontally rotatable relative to the rotating shaft fixing seat. The centrifugal drive device is installed on the centrifugal fixing seat and connected to the lower end of the rotating shaft to drive the rotating shaft to rotate horizontally. The rotor includes a rotor base plate and multiple screw tube placement plates. The rotor base plate is horizontally sleeved on the upper end of the rotating shaft. The screw tube placement plates are inclined outward and upward from the outer peripheral edge of the rotor base plate. The screw tube placement plates are provided with screw tube insertion holes in a direction perpendicular to themselves. The multiple screw tube placement plates are horizontally... The rotating components are arranged at intervals around the upper end of the rotating shaft; the rotating assembly includes an arc-shaped rack, a rack connector, a gear, and a rotation drive device. The arc-shaped rack is vertically arranged and extends along the left-right direction, protruding downwards in an arc shape. The arc-shaped rack is located behind the front support frame and below the centrifugal fixing seat. The rack connector is located between the centrifugal fixing seat and the arc-shaped rack, connecting the centrifugal fixing seat and the arc-shaped rack respectively. The gear is vertically arranged and extends along the front-back direction. The gear is located below the arc-shaped rack and meshes with it. The rotation drive device is mounted on the base plate and connected to the gear to drive the gear to rotate around the front-back direction. The centrifugal mixing assembly has a positioning position. At the positioning position, one of the screw tube placement plates is in a horizontal position. The rotation drive device drives the gear to rotate around the front-back direction, causing the arc-shaped rack to rotate around the front-back direction, which in turn drives the rack connector to rotate around the front-back direction. Thus, the centrifugal fixing seat drives the centrifugal mixing assembly to rotate around the front-back direction to the positioning position.

[0016] The test tube rack includes a test tube support and a first test tube adapter. The test tube support is mounted on the base plate, and the first test tube adapter is horizontally mounted on the test tube support. The top surface of the first test tube adapter has a first insertion hole. The low-temperature storage rack includes a refrigeration device and a second test tube adapter. The refrigeration device is mounted on the base plate, and the second test tube adapter is horizontally mounted on the refrigeration device. The refrigeration device is used to cool the second test tube adapter. The top surface of the second test tube adapter has a second insertion hole. Both the first insertion hole and the second insertion hole are used to insert threaded tubes.

[0017] Preferably, the lateral movement drive device includes a front lateral movement driven wheel, a front lateral movement driving wheel, a front lateral movement timing belt, a rear lateral movement driven wheel, a rear lateral movement driving wheel, a rear lateral movement timing belt, a timing connecting rod, a lateral movement drive component, a front lateral movement slider, and a rear lateral movement slider. The front lateral movement driven wheel and the front lateral movement driving wheel are both vertically arranged and along the left-right direction, spaced apart from each other on the lateral movement support frame. The rear lateral movement driven wheel and the rear lateral movement driving wheel are both vertically arranged and along the left-right direction, spaced apart from each other on the lateral movement support frame. The front lateral movement driven wheel, the rear lateral movement driven wheel, the front lateral movement driving wheel, and the rear lateral movement driving wheel are all spaced apart front-to-back. The timing connecting rod is arranged along the front-to-back direction and located between the front lateral movement driving wheel and the rear lateral movement driving wheel, respectively connecting the front lateral movement driving wheel and the rear lateral movement driving wheel for driving the front lateral movement driving wheel and the rear lateral movement driving wheel simultaneously. The lateral movement drive component is mounted on the lateral movement support frame and connected to the synchronous connecting rod to drive the synchronous connecting rod to rotate around the front-back direction. The front lateral movement slider and the rear lateral movement slider are spaced apart from each other and are movably mounted on the front lateral movement guide rail and the rear lateral movement guide rail, respectively. The front end and the rear end of the lateral movement slide are respectively mounted on the front lateral movement slider and the rear lateral movement slider. The front lateral movement synchronous belt is vertically arranged along the left-right direction. The left and right ends of the front lateral movement synchronous belt are respectively sleeved on the front lateral movement driven wheel and the front lateral movement driving wheel. The upper part of the front lateral movement synchronous belt is connected to the front lateral movement slider. The rear lateral movement synchronous belt is vertically arranged along the left-right direction. The left and right ends of the rear lateral movement synchronous belt are respectively sleeved on the rear lateral movement driven wheel and the rear lateral movement driving wheel. The upper part of the rear lateral movement synchronous belt is connected to the rear lateral movement slider.

[0018] Preferably, there are multiple longitudinal moving guide rails, which are arranged vertically at intervals.

[0019] Preferably, the longitudinal movement drive device includes a longitudinal movement driven wheel, a longitudinal movement driving wheel, a longitudinal movement timing belt, and a longitudinal movement drive component. The longitudinal movement driven wheel and the longitudinal movement driving wheel are both vertically arranged and along the front-to-back direction, and are spaced apart from each other. The longitudinal movement driven wheel and the longitudinal movement driving wheel are both located on the left side of the transverse movement slide and are rotatably connected to the transverse movement slide around the left-to-right direction. The longitudinal movement drive component is mounted on the transverse movement slide and connected to the longitudinal movement driving wheel to drive the longitudinal movement driving wheel to rotate around the left-to-right direction. The longitudinal movement timing belt is vertically arranged and along the front-to-back direction. The front end and rear end of the longitudinal movement timing belt are respectively sleeved on the longitudinal movement driven wheel and the longitudinal movement driving wheel. The lower part of the longitudinal movement timing belt is connected to the longitudinal movement slide.

[0020] Preferably, the vertical movement drive device includes a vertical movement timing belt, a vertical movement timing pulley, and a vertical movement drive component. The vertical movement timing belt is vertically arranged along the front-back direction and located to the left of the vertical movement guide rail. The upper and lower ends of the vertical movement timing belt are both connected to the vertical movement guide rail. The vertical movement timing pulley is vertically arranged along the left-right direction and rotatably disposed in the vertical movement fixed base around the front-back direction. The vertical movement drive component is mounted on the vertical movement fixed base and connected to the vertical movement timing pulley for driving the vertical movement timing pulley to rotate around the front-back direction. The vertical movement timing pulley is located to the left of the vertical movement timing belt and engages with the vertical movement timing belt.

[0021] Preferably, the rotary drive device includes a rotary driving wheel, a rotary driven wheel, a rotary timing belt, and a rotary drive component. The rotary driving wheel and the rotary driven wheel are both horizontally arranged and spaced apart from each other. The rotary driven wheel is sleeved on the capping shaft. The rotary drive component is mounted on the capping base and connected to the rotary driving wheel to drive the rotary driving wheel to rotate horizontally. The rotary timing belt is horizontally arranged along the front-to-back direction, and the front end and rear end of the rotary timing belt are respectively sleeved on the rotary driving wheel and the rotary driven wheel.

[0022] Preferably, the right side of the clamping movable block and the left side of the clamping fixed block are respectively provided with a left clamping groove and a right clamping groove, and the left clamping groove and the right clamping groove are arranged opposite to each other at intervals.

[0023] Preferably, the two clamping mechanisms are arranged at intervals from each other.

[0024] Preferably, there are four screw tube placement plates, which are located at the front, back, left, and right of the upper end of the rotating shaft, respectively.

[0025] Preferably, the centrifugal mixing mechanism further includes a positioning and limiting component, which includes a positioning seat, a positioning rod, and a forward and backward movement drive device. The positioning seat is mounted on the rack connector and has a positioning hole along the forward and backward direction. The positioning rod is positioned along the forward and backward direction and located between the rack connector and the rear support frame. The forward and backward movement drive device is mounted on the rear support frame and connected to the rear end of the positioning rod to drive the positioning rod to move forward and backward. At the positioning position, the positioning rod is inserted into the positioning hole along the forward and backward direction. The rack connector rotates around the forward and backward direction, causing the positioning seat to rotate around the forward and backward direction. When the centrifugal mixing component rotates around the forward and backward direction to the positioning position, the positioning hole follows the positioning seat and rotates around the forward and backward direction to before the positioning rod. The forward and backward movement drive device drives the positioning rod to move forward, so that the positioning rod is inserted into the positioning hole along the forward and backward direction.

[0026] The main beneficial effects of this utility model are as follows:

[0027] 1. When using the reagent preparation equipment adapted to a fully automated workstation for biomedical research, the test tube rack is used to store screw-in tubes at room temperature, and the low-temperature storage rack is used to store screw-in tubes under refrigeration. The capping mechanism can move horizontally, vertically, and vertically through a horizontal movement mechanism, a longitudinal movement mechanism, and a vertical movement mechanism, respectively, and can be moved to any suitable position. The capping mechanism can be used to attach, transfer, and remove screw-in tubes. The clamping mechanism can clamp the screw-in tubes. In the clamped state, the capping mechanism can be used to open and close the screw-in tube caps. The centrifugal mixing mechanism can mix the liquid inside the screw-in tubes. Therefore, when used in conjunction with a pipette module, it can realize the automated preparation of reagents, thus adapting to a fully automated workstation for biomedical research, promoting the application of fully automated experimental equipment in biomedical research, and is suitable for large-scale promotion and application.

[0028] 2. When the reagent preparation equipment of the fully automated workstation for biomedical research of this utility model is used, the test tube rack is used to store screw tubes at room temperature, and the low-temperature storage rack is used to store screw tubes in cold storage. The capping mechanism can be moved horizontally, vertically, and vertically through the horizontal moving mechanism, the vertical moving mechanism, and the vertical moving mechanism, respectively, and can be moved to any suitable position. The screwing mechanism can be used to fit screw tubes, transfer screw tubes, and remove screw tubes. The clamping mechanism can clamp screw tubes. When the screw tubes are clamped, the capping mechanism can be used to open and close the screw tubes. The centrifugal mixing mechanism can mix the liquid in the screw tubes. Therefore, its design is ingenious, its structure is simple, its manufacturing is convenient, its manufacturing cost is low, and it is suitable for large-scale promotion and application.

[0029] These and other objects, features and advantages of this utility model will be fully apparent from the following detailed description and drawings, and can be achieved by the means, devices and combinations thereof specifically pointed out in the description of the utility model. Attached Figure Description

[0030] Figure 1 This is a three-dimensional schematic diagram of a specific embodiment of the reagent preparation equipment adapted to a fully automated workstation for biomedical research according to this utility model.

[0031] Figure 2 yes Figure 1 The specific embodiment shown is a three-dimensional schematic diagram without the lateral movement mechanism.

[0032] Figure 3 yes Figure 1 A perspective view of the longitudinal movement mechanism of a specific embodiment is shown.

[0033] Figure 4 yes Figure 1 A perspective view of the components of the vertical moving mechanism and the capping mechanism in the specific embodiment shown.

[0034] Figure 5 yes Figure 1 A perspective view of the clamping mechanism in a specific embodiment is shown.

[0035] Figure 6 yes Figure 1 A three-dimensional schematic diagram of the centrifugal mixing mechanism of a specific embodiment is shown.

[0036] Figure 7 yes Figure 1 A three-dimensional schematic diagram of a test tube rack according to a specific embodiment is shown.

[0037] Figure 8 yes Figure 1 A three-dimensional schematic diagram of a specific embodiment of a cryogenic storage rack is shown.

[0038] Figure 9yes Figure 1 A partial three-dimensional schematic diagram of a specific embodiment is shown.

[0039] (Symbol Explanation)

[0040] 1. Lateral movement mechanism; 11. Lateral movement support frame; 12. Front lateral movement guide rail; 13. Rear lateral movement guide rail; 14. Lateral movement slide; 15. Lateral movement drive device; 151. Front lateral movement driven wheel; 152. Front lateral movement driving wheel; 153. Front lateral movement timing belt; 154. Rear lateral movement driven wheel; 155. Rear lateral movement driving wheel; 156. Rear lateral movement timing belt; 157. Timing connecting rod; 158. Lateral movement drive component; 159. Front lateral movement slider; 160. Rear lateral movement slider;

[0041] 2. Longitudinal movement mechanism; 21. Longitudinal movement slide; 22. Longitudinal movement guide rail; 23. Longitudinal movement drive device; 231. Longitudinal movement driven wheel; 232. Longitudinal movement driving wheel; 233. Longitudinal movement timing belt; 234. Longitudinal movement drive component;

[0042] 3. Vertical moving mechanism; 31. Vertical moving fixed base; 32. Vertical moving guide rail; 33. Vertical moving drive device; 331. Vertical moving synchronous belt; 332. Vertical moving synchronous belt pulley; 333. Vertical moving drive component;

[0043] 4. Capping mechanism; 41. Capping base; 42. Capping shaft; 43. Capping head; 44. Rotary drive device; 441. Rotary drive wheel; 442. Rotary driven wheel; 443. Rotary timing belt; 444. Rotary drive component; 45. Tube ejector rod; 46. Rod drive device.

[0044] 5. Base plate;

[0045] 6. Clamping mechanism; 61. Clamping base; 62. Clamping movable block; 621. Left clamping groove; 63. Clamping fixed block; 631. Right clamping groove; 64. Clamping drive device;

[0046] 7. Centrifugal mixing mechanism; 71. Front support frame; 72. Rear support frame; 73. Centrifugal mixing assembly; 731. Centrifugal fixing seat; 732. Rotary shaft fixing seat; 733. Rotary shaft; 734. Centrifugal drive device; 735. Rotor; 736. Rotor base plate; 737. Threaded tube placement plate; 738. Threaded tube insertion hole; 74. Rotating assembly; 741. Arc-shaped rack; 742. Rack connector; 743. Gear; 744. Rotating drive device; 75. Positioning and limiting assembly; 751. Positioning seat; 752. Forward and backward movement drive device; 753. Positioning hole;

[0047] 8. Test tube rack; 81. Test tube support; 811. Left support; 812. Right support; 82. First test tube adapter; 83. First insertion hole;

[0048] 9. Low-temperature storage rack; 91. Refrigeration unit; 92. Second test tube adapter; 93. Second insertion hole;

[0049] 10. Raw material and reagent screw-in tubes;

[0050] 20. Prepare reagent screw tubes. Detailed Implementation

[0051] In order to better understand the technical content of this utility model, the following embodiments are provided for detailed description.

[0052] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0053] Please see Figures 1-9 As shown, in a specific embodiment of this utility model, the reagent preparation equipment adapted to a fully automated workstation for biomedical research includes a horizontal moving mechanism 1, a vertical moving mechanism 2, a vertical moving mechanism 3, a capping mechanism 4, a base plate 5, a clamping mechanism 6, a centrifugal mixing mechanism 7, a test tube rack 8, and a low-temperature storage rack 9, wherein:

[0054] The lateral movement mechanism 1 includes a lateral movement support frame 11, a front lateral movement guide rail 12, a rear lateral movement guide rail 13, a lateral movement slide 14, and a lateral movement drive device 15. The lateral movement support frame 11 is horizontally arranged along the left-right direction. The front lateral movement guide rail 12 and the rear lateral movement guide rail 13 are both horizontally arranged along the left-right direction and are spaced apart from each other on the lateral movement support frame 11. The lateral movement slide 14 is vertically arranged along the front-back direction and is located in the lateral movement support frame 11. The front end and rear end of the lateral movement slide 14 are movably arranged left and right on the front lateral movement guide rail 12 and the rear lateral movement guide rail 13, respectively. The lateral movement drive device 15 is mounted on the lateral movement support frame 11 and connected to the lateral movement slide 14 to drive the lateral movement slide 14 to move left and right.

[0055] The longitudinal moving mechanism 2 includes a longitudinal moving slide 21, a longitudinal moving guide rail 22, and a longitudinal moving drive device 23. The longitudinal moving guide rail 22 is vertically arranged along the front-back direction and located in the transverse moving support frame 11. The longitudinal moving guide rail 22 is located to the left of the transverse moving slide 14 and connected to the transverse moving slide 14. The longitudinal moving slide 21 is vertically arranged along the front-back direction and located in the transverse moving support frame 11. The longitudinal moving slide 21 is located to the left of the longitudinal moving guide rail 22 and is movably connected to the longitudinal moving guide rail 22. The longitudinal moving drive device 23 is installed on the transverse moving slide 14 and connected to the longitudinal moving slide 21 for driving the longitudinal moving slide 21 to move back and forth.

[0056] The vertical moving mechanism 3 includes a vertical moving fixed base 31, a vertical moving guide rail 32, and a vertical moving drive device 33. The vertical moving fixed base 31 is located in the horizontal moving support frame 11 and is located to the left of the longitudinal moving slide 21 and connected to the longitudinal moving slide 21. The vertical moving guide rail 32 is vertically arranged and vertically movably arranged in the vertical moving fixed base 31. The vertical moving drive device 33 is installed on the vertical moving fixed base 31 and connected to the vertical moving guide rail 32 for driving the vertical moving guide rail 32 to move up and down.

[0057] The capping mechanism 4 includes a capping fixing seat 41, a capping shaft 42, a capping head 43, a rotary drive device 44, a tube ejection push rod 45, and a push rod drive device 46. The capping fixing seat 41 is located below the vertical moving fixing seat 31 and is connected to the vertical moving guide rail 32. The capping shaft 42 is vertically arranged and located to the left of the capping fixing seat 41 and is horizontally rotatably connected to the capping fixing seat 41. The capping head 43 is horizontally arranged and downwardly positioned for fitting onto the cap of the threaded tube. The capping head 43 is located on the capping shaft 44. Below 2, the capping shaft 42 is connected. The rotation drive device 44 is installed on the capping fixing seat 41 and connected to the capping shaft 42 to drive the capping shaft 42 to rotate horizontally. The capping shaft 42 is vertically hollow. The tube ejection push rod 45 is vertically arranged and vertically movable and inserted into the capping shaft 42. The upper end of the tube ejection push rod 45 protrudes upward from the capping shaft 42. The push rod drive device 46 is installed on the capping fixing seat 41 and connected to the upper end of the tube ejection push rod 45 to drive the tube ejection push rod 45 to move vertically.

[0058] The base plate 5 is horizontally arranged and along the front-back direction. The base plate 5 is located in the transverse moving support frame 11 and below the capping mechanism 4.

[0059] The clamping mechanism 6 includes a clamping base 61, a clamping movable block 62, a clamping fixed block 63, and a clamping drive device 64. The clamping base 61 is vertically arranged and positioned on the base plate 5 along the left-right direction. The clamping movable block 62 and the clamping fixed block 63 are both vertically arranged and positioned along the front-back direction, and are spaced apart from each other on the left and right. The clamping fixed block 63 is positioned on the clamping base 61. The clamping movable block 62 is movably positioned on the clamping base 61. The clamping drive device 64 is mounted on the clamping base 61 and connected to the clamping movable block 62 to drive the clamping movable block 62 to move left and right. The number of clamping mechanisms 6 is two.

[0060] The centrifugal mixing mechanism 7 includes a front support frame 71, a rear support frame 72, a centrifugal mixing assembly 73, and a rotating assembly 74. The front support frame 71 and the rear support frame 72 are both vertically arranged and positioned along the left-right direction, spaced apart from each other on the base plate 5. The centrifugal mixing assembly 73 includes a centrifugal fixing seat 731, a rotating shaft fixing seat 732, a rotating shaft 733, a centrifugal drive device 734, and a rotor 735. The centrifugal fixing seat 731 is located between the front support frame 71 and the rear support frame 72 and is rotatably connected to them in the front-back direction. The rotating shaft fixing seat 732 is mounted on the centrifugal fixing seat 731. The rotating shaft 733... 3. Vertically arranged, the rotating shaft 733 has the rotating shaft fixing seat 732 vertically passing through its middle part and is horizontally rotatable relative to the rotating shaft fixing seat 732. The centrifugal drive device 734 is installed on the centrifugal fixing seat 731 and connected to the lower end of the rotating shaft 733 to drive the rotating shaft 733 to rotate horizontally. The rotor 735 includes a rotor base plate 736 and multiple screw tube placement plates 737. The rotor base plate 736 is horizontally sleeved on the upper end of the rotating shaft 733. The screw tube placement plates 737 are inclined outward and upward from the outer peripheral edge of the rotor base plate 736. The screw tube placement plates 737 are provided with screw tube insertion holes 738 in a direction perpendicular to themselves. Multiple screw tubes are placed... The mounting plates 737 are horizontally arranged around the upper end of the rotating shaft 733 at intervals. The rotating assembly 74 includes an arc-shaped rack 741, a rack connector 742, a gear 743, and a rotating drive device 744. The arc-shaped rack 741 is vertically arranged and extends along the left-right direction, protruding downwards in an arc shape. The arc-shaped rack 741 is located behind the front support frame 71 and below the centrifugal fixing seat 731. The rack connector 742 is located between the centrifugal fixing seat 731 and the arc-shaped rack 741, connecting the centrifugal fixing seat 731 and the arc-shaped rack 741 respectively. The gear 743 is vertically arranged and extends along the front-back direction. The gear 743 is located in the arc-shaped... The rack 741 engages with the arc-shaped rack 741. The rotation drive device 744 is mounted on the base plate 5 and connected to the gear 743 to drive the gear 743 to rotate around the front-back direction. The centrifugal mixing assembly 73 has a positioning position. In the positioning position, one of the screw tube placement plates 737 is in a horizontal position. The rotation drive device 744 drives the gear 743 to rotate around the front-back direction, causing the arc-shaped rack 741 to rotate around the front-back direction, which in turn drives the rack connector 742 to rotate around the front-back direction. Thus, the centrifugal fixing seat 731 drives the centrifugal mixing assembly 73 to rotate around the front-back direction to the positioning position.

[0061] The test tube rack 8 includes a test tube support 81 and a first test tube adapter 82. The test tube support 81 is mounted on the base plate 5, and the first test tube adapter 82 is horizontally mounted on the test tube support 81. The top surface of the first test tube adapter 82 is vertically provided with a first insertion hole 83. The low-temperature storage rack 9 includes a refrigeration device 91 and a second test tube adapter 92. The refrigeration device 91 is mounted on the base plate 5, and the second test tube adapter 92 is horizontally mounted on the refrigeration device 91. The refrigeration device 91 is used to cool the second test tube adapter 92. The top surface of the second test tube adapter 92 is vertically provided with a second insertion hole 93. Both the first insertion hole 83 and the second insertion hole 93 are used to insert threaded tubes.

[0062] The lateral movement drive device 15 can have any suitable configuration; please refer to [link / reference]. Figure 1As shown, in a specific embodiment of this utility model, the lateral movement drive device 15 includes a front lateral movement driven wheel 151, a front lateral movement driving wheel 152, a front lateral movement synchronous belt 153, a rear lateral movement driven wheel 154, a rear lateral movement driving wheel 155, a rear lateral movement synchronous belt 156, a synchronous connecting rod 157, a lateral movement drive component 158, a front lateral movement slider 159, and a rear lateral movement slider 160. The front lateral movement driven wheel 151 and the front lateral movement driving wheel 152 are both vertically arranged and along the left-right direction, and are spaced apart from each other on the lateral movement support frame 11. The rear lateral movement driven wheel... Both the front lateral movement drive wheel 154 and the rear lateral movement drive wheel 155 are vertically arranged and along the left-right direction, spaced apart from each other on the lateral movement support frame 11. The front lateral movement driven wheel 151 and the rear lateral movement driven wheel 154, as well as the front lateral movement drive wheel 152 and the rear lateral movement drive wheel 155, are spaced apart from each other. The synchronous connecting rod 157 is arranged along the front-back direction and located between the front lateral movement drive wheel 152 and the rear lateral movement drive wheel 155, respectively connecting the front lateral movement drive wheel 152 and the rear lateral movement drive wheel 155 for driving the front lateral movement drive wheel 152 and the rear lateral movement drive wheel 155. The rear lateral movement drive wheel 155 rotates synchronously around the front-rear direction. The lateral movement drive component 158 ​​is mounted on the lateral movement support frame 11 and connected to the synchronous connecting rod 157 to drive the synchronous connecting rod 157 to rotate around the front-rear direction. The front lateral movement slider 159 and the rear lateral movement slider 160 are spaced apart from each other and are movably mounted left and right on the front lateral movement guide rail 12 and the rear lateral movement guide rail 13, respectively. The front end and the rear end of the lateral movement slide block 14 are respectively mounted on the front lateral movement slider 159 and the rear lateral movement slider 160. A forward lateral moving synchronous belt 153 is vertically positioned and arranged along the left-right direction. The left and right ends of the forward lateral moving synchronous belt 153 are respectively fitted onto the forward lateral moving driven wheel 151 and the forward lateral moving driving wheel 152. The upper belt portion of the forward lateral moving synchronous belt 153 is connected to the forward lateral moving slider 159. A rear lateral moving synchronous belt 156 is vertically positioned and arranged along the left-right direction. The left and right ends of the rear lateral moving synchronous belt 156 are respectively fitted onto the rear lateral moving driven wheel 154 and the rear lateral moving driving wheel 155. The upper belt portion of the rear lateral moving synchronous belt 156 is connected to the rear lateral moving slider 160.

[0063] With the above configuration, when the lateral movement drive device 15 needs to drive the lateral movement slide 14 to move left and right, the lateral movement drive component 158 ​​drives the synchronous connecting rod 157 to rotate around the front-rear direction, causing the front lateral movement drive wheel 152 and the rear lateral movement drive wheel 155 to rotate synchronously around the front-rear direction, thereby causing the front lateral movement synchronous belt 153 and the rear lateral movement synchronous belt 156 to rotate around the front-rear direction, which in turn causes the front lateral movement slider 159 and the rear lateral movement slider 160 to move left and right, and finally causes the lateral movement slide 14 to move left and right.

[0064] The lateral movement drive component 158 ​​can be any suitable drive component. In a specific embodiment of this utility model, the lateral movement drive component 158 ​​is a rotary motor.

[0065] The number of longitudinal moving guide rails 22 can be determined as needed. Preferably, there are multiple longitudinal moving guide rails 22, which are arranged vertically at intervals. The term "multiple" refers to two or more. Please refer to [link to relevant documentation]. Figures 2-3 As shown, in a specific embodiment of this utility model, the number of longitudinal moving guide rails 22 is two.

[0066] The longitudinal movement drive device 23 can have any suitable configuration; please refer to [link / reference]. Figures 1-3 As shown, in a specific embodiment of this utility model, the longitudinal movement drive device 23 includes a longitudinal movement driven wheel 231, a longitudinal movement driving wheel 232, a longitudinal movement synchronous belt 233, and a longitudinal movement drive component 234. The longitudinal movement driven wheel 231 and the longitudinal movement driving wheel 232 are both vertically arranged and along the front-rear direction, spaced apart from each other. Both the longitudinal movement driven wheel 231 and the longitudinal movement driving wheel 232 are located to the left of the transverse movement slide 14 and are rotatably connected around the left-right direction. The lateral moving slide 14 is described above. The longitudinal moving drive component 234 is installed on the lateral moving slide 14 and connected to the longitudinal moving drive wheel 232 for driving the longitudinal moving drive wheel 232 to rotate around the left and right direction. The longitudinal moving synchronous belt 233 is arranged vertically and along the front and back direction. The front end and rear end of the longitudinal moving synchronous belt 233 are respectively sleeved on the longitudinal moving driven wheel 231 and the longitudinal moving drive wheel 232. The lower part of the longitudinal moving synchronous belt 233 is connected to the longitudinal moving slide 21.

[0067] With the above configuration, when the longitudinal moving slide 21 needs to be moved back and forth by the longitudinal moving drive device 23, the longitudinal moving drive component 234 drives the longitudinal moving drive wheel 232 to rotate around the left and right direction, thereby driving the longitudinal moving synchronous belt 233 to rotate around the left and right direction, thereby driving the longitudinal moving slide 21 to move back and forth.

[0068] The longitudinal movement drive component 234 can be any suitable drive component. In a specific embodiment of this utility model, the longitudinal movement drive component 234 is a rotary motor.

[0069] The vertical movement drive device 33 can have any suitable configuration; please refer to [link / reference]. Figure 4 As shown, in a specific embodiment of this utility model, the vertical movement drive device 33 includes a vertical movement synchronous belt 331, a vertical movement synchronous pulley 332, and a vertical movement drive component 333. The vertical movement synchronous belt 331 is vertically arranged and along the front-back direction and located to the left of the vertical movement guide rail 32. The upper and lower ends of the vertical movement synchronous belt 331 are both connected to the vertical movement guide rail 32. The vertical movement synchronous pulley 332 is vertically arranged and along the left-right direction and is rotatably arranged in the vertical movement fixed base 31 around the front-back direction. The vertical movement drive component 333 is installed on the vertical movement fixed base 31 and connected to the vertical movement synchronous pulley 332 for driving the vertical movement synchronous pulley 332 to rotate around the front-back direction. The vertical movement synchronous pulley 332 is located to the left of the vertical movement synchronous belt 331 and engages with the vertical movement synchronous belt 331.

[0070] With the above configuration, when the vertical moving guide rail 32 needs to be moved up and down by the vertical moving drive device 33, the vertical moving synchronous pulley 332 is driven to rotate around the front-back direction by the vertical moving drive component 333. Since the vertical moving synchronous pulley 332 is located to the left of the vertical moving synchronous belt 331 and meshes with the vertical moving synchronous belt 331, similar to a gear and rack combination, the vertical moving guide rail 32 can be driven to move vertically by the vertical moving synchronous belt 331.

[0071] The vertical movement drive component 333 can be any suitable drive component. In a specific embodiment of this utility model, the vertical movement drive component 333 is a rotary motor.

[0072] The rotary drive device 44 can have any suitable configuration; please refer to [link / reference]. Figure 4As shown, in a specific embodiment of this utility model, the rotary drive device 44 includes a rotary driving wheel 441, a rotary driven wheel 442, a rotary timing belt 443, and a rotary drive component 444. The rotary driving wheel 441 and the rotary driven wheel 442 are both horizontally arranged and spaced apart from each other. The rotary driven wheel 442 is sleeved on the capping shaft 42. The rotary drive component 444 is mounted on the capping fixing seat 41 and connected to the rotary driving wheel 441 to drive the rotary driving wheel 441 to rotate horizontally. The rotary timing belt 443 is horizontally arranged along the front-to-back direction. The front end and rear end of the rotary timing belt 443 are respectively sleeved on the rotary driving wheel 441 and the rotary driven wheel 442.

[0073] With the above configuration, when the rotary drive device 44 needs to drive the capping shaft 42 to rotate horizontally, the rotary drive component 444 drives the rotary drive wheel 441 to rotate horizontally, which in turn drives the rotary driven wheel 442 to rotate horizontally via the rotary timing belt 443, thereby driving the capping shaft 42 to rotate horizontally.

[0074] The rotary drive component 444 can be any suitable drive component. In one specific embodiment of this utility model, the rotary drive component 444 is a rotary motor.

[0075] The push rod drive device 46 can be any suitable drive device. In a specific embodiment of this utility model, the push rod drive device 46 is a vertical telescopic motor.

[0076] The right side of the clamping movable block 62 and the left side of the clamping fixed block 63 can have any suitable configuration; please refer to [link / reference]. Figure 5 As shown, in a specific embodiment of this utility model, the right side of the clamping movable block 62 and the left side of the clamping fixed block 63 are respectively provided with a left clamping groove 621 and a right clamping groove 631, which are arranged vertically relative to each other.

[0077] The clamping drive device 64 can be any suitable drive device. In a specific embodiment of this utility model, the clamping drive device 64 is a left-right telescopic motor.

[0078] The two clamping mechanisms 6 can have any suitable relative position; please refer to [link / reference]. Figure 9 As shown, in a specific embodiment of this utility model, the two clamping mechanisms 6 are arranged at intervals from each other.

[0079] The centrifugal drive device 734 can be any suitable drive device. In one specific embodiment of the present invention, the centrifugal drive device 734 is a rotary motor.

[0080] The number of the screw-in tube placement plates 737 can be determined as needed. The term "multiple plates" refers to two or more plates. Please refer to [link / reference]. Figure 6 As shown, in a specific embodiment of this utility model, there are four screw tube placement plates 737, which are located at the front, back, left, and right of the upper end of the rotating shaft 733, respectively.

[0081] The rotation drive device 744 can be any suitable drive device. In a specific embodiment of this utility model, the rotation drive device 744 is a rotary motor.

[0082] The centrifugal mixing mechanism 7 may also include any other suitable configuration; please refer to [link / reference]. Figure 6 As shown, in a specific embodiment of this utility model, the centrifugal mixing mechanism 7 further includes a positioning and limiting component 75. The positioning and limiting component 75 includes a positioning seat 751, a positioning rod (not shown in the figure), and a front-to-back movement driving device 752. The positioning seat 751 is mounted on the rack connector 742. The positioning seat 751 is provided with a positioning hole 753 along the front-to-back direction. The positioning rod is arranged along the front-to-back direction and located between the rack connector 742 and the rear support frame 72. The front-to-back movement driving device 752 is mounted on the rear support frame 72 and connected to the rear end of the positioning rod for... The positioning rod is driven to move back and forth. At the positioning position, the positioning rod is inserted into the positioning hole 753 along the back and forth direction. The positioning seat 751 is driven to rotate around the back and forth direction by the rack and pinion connector 742. When the centrifugal mixing assembly 73 rotates around the back and forth direction to the positioning position, the positioning hole 753 follows the positioning seat 751 to rotate around the back and forth direction before the positioning rod. The positioning rod is then driven to move forward by the back and forth movement drive device 752, so that the positioning rod is inserted into the positioning hole 753 along the back and forth direction.

[0083] The forward and backward movement drive device 752 can be any suitable drive device. In a specific embodiment of this utility model, the forward and backward movement drive device 752 is a forward and backward telescopic motor.

[0084] The test tube holder 81 can have any suitable configuration; please refer to [link / reference]. Figure 7As shown, in a specific embodiment of this utility model, the test tube support 81 includes a left support 811 and a right support 812. The left support 811 and the right support 812 are both vertically arranged and arranged along the front-back direction and are spaced apart from each other on the left and right sides. The first test tube adapter seat 82 is horizontally arranged and arranged along the left-right direction. The left end and the right end of the first test tube adapter seat 82 are respectively arranged on the left support 811 and the right support 812.

[0085] The refrigeration device 91 and the second test tube adapter 92 can be arranged in any suitable orientation. Please refer to [link / reference]. Figures 1-2 As shown, in a specific embodiment of this utility model, the refrigeration device 91 is arranged vertically and along the left-right direction, and the second test tube adapter 92 is arranged horizontally and along the left-right direction.

[0086] The test tube rack 8 and the cryopreservation rack 9 can have any suitable positional relationship; please refer to [link / reference]. Figures 1-2 As shown, in a specific embodiment of this utility model, the test tube rack 8 is located after the cryopreservation rack 9.

[0087] The clamping mechanism 6, the centrifugal mixing mechanism 7, and the test tube rack 8 can have any suitable positional relationship. Please refer to [link / reference]. Figures 1-2 As shown, in a specific embodiment of this utility model, the clamping mechanism 6 is located behind the test tube rack 8, and the centrifugal mixing mechanism 7 is located to the left rear of the test tube rack 8 and to the left of the clamping mechanism 6.

[0088] In use, raw material reagent screw tubes 10 that are stored at room temperature are placed on the test tube rack 8 and vertically inserted into the first insertion hole 83. There can be multiple raw material reagent screw tubes 10 that are stored at room temperature, for example, four. Raw material reagent screw tubes 10 that need to be refrigerated are placed on the low temperature storage rack 9 and vertically inserted into the second insertion hole 93. The refrigeration device 91 can use semiconductor refrigeration technology to obtain a low temperature of, for example, 4 degrees Celsius. There can be multiple raw material reagent screw tubes 10 that need to be refrigerated, for example, four.

[0089] The reagent preparation screw tube 20 (empty tube) is used for preparing reagents and can be placed on the test tube rack 8 or on the low-temperature storage rack 9.

[0090] Now, different amounts of various raw materials and reagents need to be taken from multiple raw material and reagent screw tubes 10 and transferred to the preparation reagent screw tube 20. The cap of the preparation reagent screw tube 20 is screwed on, and then the various raw materials and reagents in the preparation reagent screw tube 20 are mixed to prepare the experimental reagent. Then, the preparation reagent screw tube 20 is transferred to the room temperature storage area or the cold storage area for storage.

[0091] The capping mechanism 4 can move laterally, longitudinally, and vertically through the lateral moving mechanism 1, the longitudinal moving mechanism 2, and the vertical moving mechanism 3, respectively. Specifically:

[0092] Lateral movement: The lateral movement slide 14 is driven to move left and right by the lateral movement drive device 15;

[0093] Longitudinal movement: The longitudinal movement slide 21 is driven to move back and forth by the longitudinal movement drive device 23;

[0094] Vertical movement: The vertical movement guide rail 32 is driven to move up and down by the vertical movement drive device 33.

[0095] The capping mechanism 4 moves to above the screw-in tube to be operated (which can be the reagent screw-in tube 20 or the raw material reagent screw-in tube 10) via the lateral moving mechanism 1 and the longitudinal moving mechanism 2, so that the capping head 43 is aligned with the cap of the screw-in tube. The capping mechanism 4 moves downward via the vertical moving mechanism 3, so that the capping head 43 covers and locks the cap of the screw-in tube. The capping mechanism 4 moves upward via the vertical moving mechanism 3, lifting the entire screw-in tube. The capping mechanism 4 moves to the clamping machine via the lateral moving mechanism 1 and the longitudinal moving mechanism 2. Above the structure 6, the capping head 43 is aligned with the left side of the clamping block 63. The capping mechanism 4 moves downward via the vertical moving mechanism 3, causing the entire screw tube to move down to the left side of the clamping block 63 and fit against it. The clamping drive device 64 drives the clamping movable block 62 to move to the right until it abuts against the screw tube, thereby clamping and fixing the screw tube between the clamping movable block 62 and the clamping block 63. The rotation drive device 44 drives the capping shaft 42 to rotate horizontally, causing the capping head 43 to rotate horizontally, thus tightening the screw tube. When the cap of the tube is unscrewed, the capping mechanism 4 moves upward via the vertical moving mechanism 3, raising the cap of the screw tube. At this time, liquid can be taken from or added to the screw tube using a pipette module, for example, in a fully automated workstation for biomedical research. After the operation is completed, the capping mechanism 4 moves downward via the vertical moving mechanism 3, lowering the cap of the screw tube. The rotary drive device 44 drives the capping shaft 42 to rotate horizontally in the opposite direction, causing the capping head 43 to rotate horizontally in the opposite direction, thus screwing the cap of the screw tube on. The clamping drive device 64 then drives... The clamping movable block 62 moves to the left, thereby loosening the screw tube. The capping mechanism 4 moves upward through the vertical moving mechanism 3, lifting the entire screw tube. The capping mechanism 4 moves to above the test tube rack 8 or the low-temperature storage rack 9 through the horizontal moving mechanism 1 and the vertical moving mechanism 2. The capping mechanism 4 moves downward through the vertical moving mechanism 3, inserting the screw tube into the first insertion hole 83 or the second insertion hole 93. The push rod driving device 46 drives the tube ejection push rod 45 downward, pushing the cap of the screw tube downward out of the capping head 43, thereby pushing the screw tube down.

[0096] Through the above operations, the raw material reagent screw tube 10 and the preparation reagent screw tube 20 can be clamped and fixed in the two clamping mechanisms 6 respectively. For example, the front clamping mechanism 6 clamps and fixes the raw material reagent screw tube 10, and the rear clamping mechanism 6 clamps and fixes the preparation reagent screw tube 20. Figure 9 As shown, unscrew the cap of the raw material reagent screw tube 10. At this time, the raw material reagent in the raw material reagent screw tube 10 can be taken out through another pipette module. After taking it out, screw the cap of the raw material reagent screw tube 10 back on. Then unscrew the cap of the preparation reagent screw tube 20. The raw material reagent can be transferred to the preparation reagent screw tube 20. After the transfer, screw the cap of the preparation reagent screw tube 20 back on. Then the raw material reagent screw tube 10 can be put back in its original position. Replace another raw material reagent screw tube 10 to take and transfer the liquid. In this way, the raw material reagent in multiple raw material reagent screw tubes 10 can be taken and transferred to the preparation reagent screw tube 20 until all liquid is taken and the cap of the preparation reagent screw tube 20 is screwed back on.

[0097] The centrifugal mixing assembly 73 is driven to rotate in the front-back direction to the positioning position by the rotating assembly 74. Specifically, the gear 743 is driven to rotate in the front-back direction by the rotating drive device 744, which causes the arc rack 741 to rotate in the front-back direction, thereby driving the rack connector 742 to rotate in the front-back direction, which in turn drives the centrifugal fixing seat 731 to rotate in the front-back direction, and finally drives the rotor 735 to rotate in the front-back direction, so that one of the screw tube placement plates 737 is in a horizontal position. The screw capping mechanism 4 can vertically insert the reagent screw tube 20 into the screw tube insertion hole 738. The centrifugal drive device 734 drives the rotating shaft 733 to rotate, which drives the rotor 735 to rotate, so that the screw tube placement plates 737 are in a horizontal position one by one. The screw capping mechanism 4 can vertically pick up and put down the screw tubes in the screw tube placement plates 737 one by one. After the screw tube is placed, the centrifugal mixing component 73 is driven to rotate in opposite directions around the front and back direction to reset by the rotating component 74. Then, the centrifugal driving device 734 drives the rotating shaft 733 to rotate horizontally in both directions, which drives the rotor 735 to rotate horizontally in both directions, so as to fully mix the various raw materials and reagents in the reagent preparation screw tube 20.

[0098] Afterwards, the screw capping mechanism 4 completes the transfer of the reagent screw tube 20, which can be transferred to the test tube rack 8 for storage or to the low temperature storage rack 9 for refrigeration, as needed.

[0099] Therefore, this utility model provides a reagent preparation device adapted to a fully automated workstation for biomedical research. This device can perform operations such as opening and closing screw caps, mixing liquids, transferring screw caps, and refrigerating screw caps, basically covering the reagent preparation steps required for biochemical experiments. It can be used in conjunction with an automated liquid handling platform, with the liquid transfer and dispensing completed by the pipette module of the automated liquid platform. It can be integrated with existing fully automated experimental platforms, filling the gaps in their reagent preparation functions.

[0100] This utility model is ingeniously designed, compact in structure, occupies little space, is easy to install, and is suitable for use in conjunction with a fully automated biochemical experimental workstation.

[0101] In summary, the reagent preparation equipment adapted to fully automated workstations for biomedical research, combined with the pipette module, enables automated reagent preparation. This allows it to be adapted to fully automated workstations for biomedical research, promoting the application of fully automated experimental equipment in biomedical research. The design is ingenious, the structure is simple, manufacturing is easy, and the manufacturing cost is low, making it suitable for large-scale promotion and application.

[0102] Therefore, it is evident that the objective of this utility model has been fully and effectively achieved. The function and structural principles of this utility model have been demonstrated and explained in the embodiments. Without departing from the stated principles, any modifications can be made to the implementation methods. Therefore, this utility model includes all modified embodiments based on the spirit and scope of the claims.

Claims

1. A reagent preparation device adapted to a fully automated workstation for biomedical research, characterized in that, The device comprises a lateral moving mechanism, a longitudinal moving mechanism, a vertical moving mechanism, a cap screwing mechanism, a bottom plate, a clamping mechanism, a centrifugal mixing mechanism, a test tube rack and a low temperature storage rack, wherein: The lateral moving mechanism comprises a lateral moving support frame, a front lateral moving guide rail, a rear lateral moving guide rail, a lateral moving slide and a lateral moving driving device, the lateral moving support frame is horizontally arranged and arranged along the left-right direction, the front lateral moving guide rail and the rear lateral moving guide rail are both horizontally arranged and arranged along the left-right direction and arranged on the lateral moving support frame in front of and behind each other, the lateral moving slide is vertically arranged and arranged along the front-rear direction and located in the lateral moving support frame, the front end and the rear end of the lateral moving slide are arranged on the front lateral moving guide rail and the rear lateral moving guide rail respectively and left-right movably, and the lateral moving driving device is installed on the lateral moving support frame and connected with the lateral moving slide for driving the lateral moving slide to move left and right. The longitudinal moving mechanism comprises a longitudinal moving slide, a longitudinal moving guide rail and a longitudinal moving driving device, the longitudinal moving guide rail is vertically arranged and arranged along the front-rear direction and located in the lateral moving support frame, the longitudinal moving guide rail is located on the left side of the lateral moving slide and connected with the lateral moving slide, the longitudinal moving slide is vertically arranged and arranged along the front-rear direction and located in the lateral moving support frame, the longitudinal moving slide is located on the left side of the longitudinal moving guide rail and connected with the longitudinal moving guide rail movably in front of and behind each other, and the longitudinal moving driving device is installed on the lateral moving slide and connected with the longitudinal moving slide for driving the longitudinal moving slide to move forward and backward. The vertical moving mechanism comprises a vertical moving fixed seat, a vertical moving guide rail and a vertical moving driving device, the vertical moving fixed seat is located in the lateral moving support frame and on the left side of the longitudinal moving slide and connected with the longitudinal moving slide, the vertical moving guide rail is vertically arranged and vertically movably arranged in the vertical moving fixed seat, and the vertical moving driving device is installed on the vertical moving fixed seat and connected with the vertical moving guide rail for driving the vertical moving guide rail to move up and down. The rotating cap mechanism comprises a rotating cap fixing base, a rotating cap shaft, a rotating cap head, a rotating driving device, a tube withdrawing push rod and a push rod driving device, the rotating cap fixing base is located below the vertical moving fixing base and is connected with the vertical moving guide rail, the rotating cap shaft is vertically arranged and is located left to the rotating cap fixing base and is horizontally and rotatably connected with the rotating cap fixing base, the rotating cap head is horizontally arranged and is downward arranged for sleeving on the cap of a screw pipe, the rotating cap head is located below the rotating cap shaft and is connected with the rotating cap shaft, the rotating driving device is installed on the rotating cap fixing base and is connected with the rotating cap shaft for driving the rotating cap shaft to horizontally rotate, the rotating cap shaft is vertically hollow, the tube withdrawing push rod is vertically arranged and is vertically movably inserted in the rotating cap shaft, the upper end of the tube withdrawing push rod protrudes upward from the rotating cap shaft, and the push rod driving device is installed on the rotating cap fixing base and is connected with the upper end of the tube withdrawing push rod for driving the tube withdrawing push rod to vertically move; The bottom plate is horizontally arranged and is arranged along the front-back direction, the bottom plate is located in the lateral moving support frame and is located below the rotating cap mechanism; The clamping mechanism comprises a clamping base, a clamping movable block, a clamping fixed block and a clamping driving device, the clamping base is vertically arranged and is arranged on the bottom plate along the left-right direction, the clamping movable block and the clamping fixed block are both vertically arranged and are both arranged along the front-back direction and are left-right spaced apart from each other, the clamping fixed block is arranged on the clamping base, the clamping movable block is left-right movably arranged on the clamping base, the clamping driving device is installed on the clamping base and is connected with the clamping movable block for driving the clamping movable block to move left-right, and the number of the clamping mechanism is two. The centrifugal mixing mechanism comprises a front support frame, a rear support frame, a centrifugal mixing assembly and a rotating assembly, the front support frame and the rear support frame are both vertically arranged and both arranged along the left-right direction and spaced apart from each other in front of and behind the bottom plate; the centrifugal mixing assembly comprises a centrifugal fixing seat, a rotating shaft fixing seat, a rotating shaft, a centrifugal driving device and a rotor, the centrifugal fixing seat is located between the front support frame and the rear support frame and is rotatably connected to the front support frame and the rear support frame in the front-rear direction respectively, the rotating shaft fixing seat is arranged on the centrifugal fixing seat, the rotating shaft is vertically arranged, the middle part of the rotating shaft vertically penetrates the rotating shaft fixing seat and is horizontally rotatably arranged relative to the rotating shaft fixing seat, the centrifugal driving device is mounted on the centrifugal fixing seat and connected to the lower end of the rotating shaft for driving the rotating shaft to rotate horizontally, the rotor comprises a rotor bottom plate and a plurality of screw pipe placing plates, the rotor bottom plate is horizontally sleeved outside the upper end of the rotating shaft, the screw pipe placing plates are inclined outward and upward from the outer peripheral edge of the rotor bottom plate, the screw pipe placing plates are provided with screw pipe insertion holes in a direction perpendicular to themselves, and the plurality of screw pipe placing plates are arranged in a spaced apart manner around the upper end of the rotating shaft; the rotating assembly comprises an arc-shaped rack, a rack connecting piece, a gear and a rotating driving device, the arc-shaped rack is vertically arranged and arranged along the left-right direction and protrudes downward in an arc shape, the arc-shaped rack is located behind the front support frame and below the centrifugal fixing seat, the rack connecting piece is located between the centrifugal fixing seat and the arc-shaped rack and connected to the centrifugal fixing seat and the arc-shaped rack respectively, the gear is vertically arranged and arranged along the front-rear direction, the gear is located below the arc-shaped rack and engages the arc-shaped rack, and the rotating driving device is mounted on the bottom plate and connected to the gear for driving the gear to rotate around the front-rear direction; the centrifugal mixing assembly has a positioning position, in which one of the screw pipe placing plates is in a horizontal position, the gear is driven by the rotating driving device to rotate around the front-rear direction, so that the arc-shaped rack rotates around the front-rear direction, the rack connecting piece is driven to rotate around the front-rear direction, and the centrifugal mixing assembly is driven by the centrifugal fixing seat to rotate around the front-rear direction to the positioning position; The test tube rack comprises a test tube support and a first test tube adapter, the test tube support is arranged on the bottom plate, the first test tube adapter is horizontally arranged on the test tube support, the top surface of the first test tube adapter is vertically provided with a first insertion hole, the low-temperature storage rack comprises a refrigeration device and a second test tube adapter, the refrigeration device is arranged on the bottom plate, the second test tube adapter is horizontally arranged on the refrigeration device, the refrigeration device is used for cooling the second test tube adapter, and the top surface of the second test tube adapter is vertically provided with a second insertion hole; the first insertion hole and the second insertion hole are both used for inserting a screw pipe therein.

2. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The lateral movement driving device comprises front lateral movement driven wheels, front lateral movement driving wheels, front lateral movement synchronous belts, rear lateral movement driven wheels, rear lateral movement driving wheels, rear lateral movement synchronous belts, synchronous connecting rods, a lateral movement driving component, a front lateral movement sliding block and a rear lateral movement sliding block. The front lateral movement driven wheels and the front lateral movement driving wheels are vertically arranged and arranged along the left-right direction and spaced apart from each other left and right on the lateral movement support frame. The rear lateral movement driven wheels and the rear lateral movement driving wheels are vertically arranged and arranged along the left-right direction and spaced apart from each other left and right on the lateral movement support frame. The front lateral movement driven wheels and the rear lateral movement driven wheels and the front lateral movement driving wheels and the rear lateral movement driving wheels are spaced apart from each other front and back. The synchronous connecting rods are arranged along the front-back direction and located between the front lateral movement driving wheels and the rear lateral movement driving wheels and connected to the front lateral movement driving wheels and the rear lateral movement driving wheels respectively for driving the front lateral movement driving wheels and the rear lateral movement driving wheels to rotate synchronously around the front-back direction. The lateral movement driving component is installed on the lateral movement support frame and connected to the synchronous connecting rods for driving the synchronous connecting rods to rotate around the front-back direction. The front lateral movement sliding block and the rear lateral movement sliding block are spaced apart from each other front and back and arranged left and right on the front lateral movement guide rails and the rear lateral movement guide rails respectively. The front end of the lateral movement sliding seat and the rear end of the lateral movement sliding seat are arranged on the front lateral movement sliding block and the rear lateral movement sliding block respectively. The front lateral movement synchronous belts are vertically arranged and arranged along the left-right direction. The left end and the right end of the front lateral movement synchronous belts are sleeved on the front lateral movement driven wheels and the front lateral movement driving wheels respectively. The upper side belt part of the front lateral movement synchronous belts is connected to the front lateral movement sliding block. The rear lateral movement synchronous belts are vertically arranged and arranged along the left-right direction. The left end and the right end of the rear lateral movement synchronous belts are sleeved on the rear lateral movement driven wheels and the rear lateral movement driving wheels respectively. The upper side belt part of the rear lateral movement synchronous belts is connected to the rear lateral movement sliding block.

3. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The number of the longitudinal movement guide rails is multiple. The multiple longitudinal movement guide rails are vertically spaced apart from each other.

4. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The longitudinal movement driving device comprises a longitudinal movement driven wheel, a longitudinal movement driving wheel, a longitudinal movement synchronous belt and a longitudinal movement driving component, the longitudinal movement driven wheel and the longitudinal movement driving wheel are vertically arranged and arranged along the front-back direction and are arranged in front of and behind each other, the longitudinal movement driven wheel and the longitudinal movement driving wheel are located on the left side of the transverse movement sliding seat and are rotatably connected to the transverse movement sliding seat along the left-right direction, the longitudinal movement driving component is installed on the transverse movement sliding seat and is connected to the longitudinal movement driving wheel for driving the longitudinal movement driving wheel to rotate along the left-right direction, the longitudinal movement synchronous belt is vertically arranged and arranged along the front-back direction, the front end and the rear end of the longitudinal movement synchronous belt are sleeved on the longitudinal movement driven wheel and the longitudinal movement driving wheel respectively, and the lower side of the longitudinal movement synchronous belt is connected to the longitudinal movement sliding seat.

5. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The vertical movement driving device comprises a vertical movement synchronous belt, a vertical movement synchronous belt wheel and a vertical movement driving component, the vertical movement synchronous belt is vertically arranged and arranged along the front-back direction and is located on the left side of the vertical movement guide rail, the upper end and the lower end of the vertical movement synchronous belt are connected to the vertical movement guide rail, the vertical movement synchronous belt wheel is vertically arranged and arranged along the left-right direction and is rotatably arranged in the vertical movement fixed seat along the front-back direction, and the vertical movement driving component is installed on the vertical movement fixed seat and is connected to the vertical movement synchronous belt wheel for driving the vertical movement synchronous belt wheel to rotate along the front-back direction, the vertical movement synchronous belt wheel is located on the left side of the vertical movement synchronous belt and is engaged with the vertical movement synchronous belt.

6. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The rotation driving device comprises a rotation driving wheel, a rotation driven wheel, a rotation synchronous belt and a rotation driving component, the rotation driving wheel and the rotation driven wheel are horizontally arranged and arranged in front of and behind each other, the rotation driven wheel is sleeved on the rotating cover shaft, the rotation driving component is installed on the rotating cover fixed seat and is connected to the rotation driving wheel for driving the rotation driving wheel to rotate horizontally, and the rotation synchronous belt is horizontally arranged and arranged along the front-back direction, the front end and the rear end of the rotation synchronous belt are sleeved on the rotation driving wheel and the rotation driven wheel respectively.

7. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The right side of the clamping movable block and the left side of the clamping fixed block are vertically provided with a left clamping groove and a right clamping groove respectively, and the left clamping groove and the right clamping groove are arranged in front of and behind each other.

8. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The two clamping mechanisms are arranged in front of and behind each other.

9. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The number of the screw pipe placing plates is four, and the four screw pipe placing plates are located in front of and behind and left and right of the upper end of the rotating shaft respectively.

10. The reagent preparation apparatus for adapting a biomedical research fully automated workstation according to claim 1, wherein, The centrifugal mixing mechanism further comprises a positioning limiting assembly, which comprises a positioning seat, a positioning rod and a front-back moving driving device. The positioning seat is installed on the rack connecting piece. The positioning seat is provided with a positioning hole in the front-back direction. The positioning rod is arranged in the front-back direction and located between the rack connecting piece and the rear support frame. The front-back moving driving device is installed on the rear support frame and connected to the rear end of the positioning rod for driving the positioning rod to move forward and backward. In the positioning position, the positioning rod is inserted into the positioning hole in the front-back direction. The rack connecting piece is rotated around the front-back direction to drive the positioning seat to rotate around the front-back direction. When the centrifugal mixing assembly is rotated around the front-back direction to the positioning position, the positioning hole is rotated around the front-back direction to the front of the positioning rod. The positioning rod is driven by the front-back moving driving device to move forward, so that the positioning rod is inserted into the positioning hole in the front-back direction.

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