Kit base and corresponding temperature control equipment

Abstract

The utility model provides a kit base and corresponding temperature control equipment, which are characterized in that a supporting plate is arranged, and a plurality of loading areas for bearing kits are arranged on one surface of the supporting plate; a heat-conducting fin is arranged on the other surface of the supporting plate corresponding to at least one loading area; and the heat-conducting fin is used for conducting a heat exchange medium so as to carry out heat exchange and temperature control on the kit. The heat conduction efficiency of the loading area is increased by utilizing the heat conduction sheet, so that the timeliness of the loading area for adjusting the temperature of the bottom of the kit is improved, the temperature of the bottom area of the kit and the temperature of other areas are kept synchronous, and the whole kit is uniformly heated.

Description

Technical Field

[0001] This utility model relates to the field of experimental equipment technology, and in particular to a reagent kit base and a corresponding temperature control device. Background Technology

[0002] A reagent kit is a box used to hold chemical reagents for detecting chemical components, drug residues, virus types, etc. It is widely used in hospitals and pharmaceutical companies. A reagent kit generally includes a box body and several sample wells within the box to hold the reagents. Common reagent kits on the market include: nucleic acid extraction kits, PCR purification kits, ELISA kits, chemiluminescence kits, and glucose detection kits.

[0003] Because the preservation and reaction of biochemical reagents usually require certain temperature conditions, and traditional reagent kit bases have poor thermal conductivity, when the reagent kit is placed horizontally on the base for temperature adjustment, such as during heating, the heat usually needs to be conducted through the base to heat the bottom area of ​​the reagent kit. This means the entire base is in contact with the heat source, which often leads to uneven heating between the bottom area and other areas of the reagent kit. It is difficult to achieve rapid and uniform heating of the entire reagent kit, resulting in uneven temperature of the reagents in the kit. This affects the preservation time of the reagents or the reaction effect, and the preservation time and reaction effect of the reagents will seriously affect the accuracy of the experimental data.

[0004] Therefore, there is an urgent need for a reagent kit base and corresponding temperature control equipment to improve the above problems. Utility Model Content

[0005] The purpose of this invention is to provide a reagent kit base and a corresponding temperature control device, which has high thermal conductivity and can achieve uniform heating of the entire reagent kit.

[0006] In a first aspect, the present invention provides a reagent kit base, the base including a tray, one side of which is provided with a plurality of loading areas for carrying reagent kits;

[0007] At least one of the trays corresponding to the loading area has a heat-conducting plate on the other side;

[0008] The heat-conducting sheet is used to conduct the heat exchange medium to control the temperature of the reagent kit.

[0009] The beneficial effects of the base of this utility model are as follows: by setting a tray, one side of the tray is provided with several loading areas for carrying the reagent kit; at least one loading area is provided on the other side of the tray with a heat-conducting sheet; the heat-conducting sheet is used to conduct heat exchange medium to control the temperature of the reagent kit. Using the heat-conducting sheet increases the heat conduction efficiency of the loading area, improves the timeliness of temperature adjustment of the bottom of the reagent kit by the loading area, and ensures that the temperature of the bottom area of ​​the reagent kit is synchronized with other areas, thereby achieving uniform heating of the entire reagent kit.

[0010] Compared to existing technologies that primarily rely on a fixed contact between the reagent kit base and the heat exchange medium (i.e., the heat exchange medium is a heat exchange mechanism with thermal conductivity, such as heated copper material), which is suitable for scenarios where the base is fixed, in some scenarios, such as automated production processes, the reagent kit base needs to be continuously fed in or out. In such cases, the reagent kit base needs to be able to move relative to the heat exchange mechanism. Because the heat-conducting sheet setting scheme of this application allows the reagent kit base to be transferred to the reagent kit base quickly and effectively without direct contact with the heat exchange mechanism, it is more conducive to the transfer and structural design of the reagent kit base and is more suitable for scenarios where the reagent kit base and the heat exchange mechanism need to move relative to each other.

[0011] Optionally, the tray surface in the loading area is further provided with a temperature exchange groove for placing sample dispensing holes of the reagent kit. Preferably, each row of sample dispensing holes corresponds to one temperature exchange groove; or preferably, the temperature exchange groove does not contact the bottom area of ​​the sample dispensing hole. Further, the distance between the temperature exchange groove and the bottom area of ​​the sample dispensing hole is 0.1-3 mm, and even further, the distance between the temperature exchange groove and the bottom area of ​​the sample dispensing hole is 0.2-1 mm. Its beneficial effects are that by setting a corresponding temperature exchange tank below each row of sample wells, the temperature of the bottom area of ​​the sample well and other areas of the sample well can be further synchronized, so that the reagent in the sample well is heated evenly. Setting the temperature exchange tank to not directly contact the bottom of the sample well can avoid local overheating / overcooling caused by direct contact. Furthermore, limiting the distance between the temperature exchange tank and the bottom area of ​​the sample well to 0.1-3 mm can avoid interference with the local temperature of the sample well while ensuring temperature control efficiency. Further limiting the distance between the temperature exchange tank and the bottom area of ​​the sample well to 0.2-1 mm can further improve temperature control efficiency and will not interfere with the local temperature of the sample well.

[0012] Optionally, the loading area has a slot adapted to the kit housing at its edge. Preferably, the sample dispensing port of the kit is located in the housing, and the slot and the housing cooperate to form a temperature exchange space around at least the lower part of the sample dispensing port. The advantage is that by providing a slot adapted to the kit housing at the edge of the loading area, the kit is easily loaded and unloaded using a snap-fit ​​connection, making it convenient to use. Furthermore, by providing a temperature exchange space around at least the lower part of the sample dispensing port, the temperature of the lower part of the sample dispensing port and other areas of the sample dispensing port can be kept synchronized, ensuring uniform heating of the entire kit.

[0013] Optionally, the tray within the loading area is further provided with heat exchange holes to allow the heat exchange medium to flow into the loading area. The advantage is that by providing heat exchange holes, the efficiency of heat flow into the loading area is improved, thereby ensuring that the bottom area of ​​the reagent kit maintains temperature synchronization with other areas, resulting in more uniform heating of the entire reagent kit.

[0014] Optionally, the heat exchange orifice includes one or more of the following features:

[0015] (1) The number of heat exchange through holes is multiple;

[0016] (4) The heat exchange through hole is strip-shaped;

[0017] (5) The extension direction of the heat exchange through holes is the same as the extension direction of the side of the loading area. The beneficial effect is that by setting multiple heat exchange through holes, which are strip-shaped and extend in the same direction as the side of the loading area, the heat flow efficiency of the loading area can be improved, making the entire reagent kit more uniformly heated.

[0018] Optionally, the temperature exchange groove is composed of strip-shaped protrusions spaced apart on the support plate; preferably, the bottom cross-section of the strip-shaped protrusion is larger than its top cross-section; and / or the sides of the strip-shaped protrusion are arc-shaped, more preferably, the curvature of the arc-shaped surface matches the curvature of the bottom of the sample dispensing hole. The beneficial effects are that setting the temperature exchange groove to consist of strip-shaped protrusions spaced apart on the support plate improves the heat exchange efficiency at the bottom of the sample dispensing hole; further, setting the bottom cross-section of the strip-shaped protrusion to be larger than its top cross-section allows for heat concentration, improving heat utilization efficiency; and setting the sides of the strip-shaped protrusion to be arc-shaped enables uniform heating of the bottom of the sample dispensing hole; further, setting the curvature of the arc-shaped surface to match the curvature of the bottom of the sample dispensing hole further ensures the temperature consistency at various points at the bottom of the sample dispensing hole.

[0019] Optionally, the number of heat-conducting sheets is multiple, with adjacent heat-conducting sheets arranged side-by-side at intervals to form heat-conducting grooves. Preferably, the intervals between all the heat-conducting sheets are the same. The advantage is that by setting multiple heat-conducting sheets, with adjacent heat-conducting sheets arranged side-by-side at intervals to form heat-conducting grooves, heat can be concentrated, improving heat conduction efficiency. Furthermore, setting the intervals between all the heat-conducting sheets to be the same ensures uniform heat conduction, guaranteeing that the temperature remains consistent throughout the loading area.

[0020] Optionally, the heat-conducting groove includes a combination of any one or more of the following features:

[0021] (1) The straight line containing the length of the heat conduction groove is parallel to the straight line containing the length of the heat exchange groove;

[0022] (2) The depth of the heat conduction groove is greater than the depth of the temperature exchange groove;

[0023] (3) The width of the heat conduction groove is smaller than the width of the temperature exchange groove;

[0024] (4) The number of heat-conducting grooves is greater than the number of heat-exchange grooves. The beneficial effect is that by setting the straight line containing the length of the heat-conducting groove to be parallel to the straight line containing the length of the heat-exchange groove, the efficiency of heat transfer to the heat-exchange groove can be improved. Setting the depth of the heat-conducting groove to be greater than the depth of the heat-exchange groove, the width of the heat-conducting groove to be less than the width of the heat-exchange groove, or the number of heat-conducting grooves to be greater than the number of heat-exchange grooves, the heat collection capacity of the heat-conducting groove can be improved, thereby improving the heat exchange efficiency of the heat-exchange groove to the bottom of the sample feeding hole.

[0025] Optionally, the tray is provided with a first mounting position for mounting a rotating connector and a second mounting position for mounting a sliding connector;

[0026] The rotating connector is used for rotating connection between the pallet and the corresponding movable seat for moving the pallet;

[0027] The sliding connector is used for sliding connection between the tray and the corresponding slide rail;

[0028] The slide rail has at least one undulating section in the direction of movement of the tray. As the sliding connector moves along the slide rail, it causes the tray to tilt by rotating relative to the moving seat. The advantage is that by providing a first mounting position and a second mounting position on the tray, and installing corresponding rotating and sliding connectors, the sliding connector's movement along the slide rail causes the tray to tilt by rotating relative to the moving seat. This allows for uniform heating and shaking of the reagents in the reagent kit, ensuring complete reaction of the reagents.

[0029] Secondly, this utility model provides a reagent kit temperature control device, including a reagent kit base and a heat exchange mechanism, which are any possible combinations of those described in the first aspect; the heat exchange mechanism is disposed below the other side of the tray of the base, and preferably, it further includes a temperature adjustment mechanism, a temperature control mechanism, and a housing, the base is disposed inside the housing, the temperature adjustment mechanism is disposed below the other side of the tray of the base, and the temperature control mechanism controls the heat exchange mechanism and the temperature adjustment mechanism to adjust the temperature inside the housing.

[0030] The beneficial effects of the temperature control device of this utility model are as follows: a heat exchange mechanism is set below the other side of the tray, which facilitates the temperature adjustment of the reagent kit base; by setting the base inside the box, not only is temperature control convenient, but temperature fluctuations can also be avoided, so as to achieve constant temperature preservation and reaction of reagents in the reagent kit; moreover, by using the tray with heat-conducting plates, the timeliness of temperature adjustment of the reagent kit can be improved, so that the temperature of the bottom area of ​​the reagent kit and other areas are kept synchronized, thereby achieving uniform heating of the entire reagent kit.

[0031] Optionally, the temperature control mechanism includes a controller and a temperature detection sensor, and the heat exchange mechanism, the temperature adjustment mechanism, and the temperature detection sensor are electrically connected to the controller respectively;

[0032] Preferably, the heat exchange mechanism includes a radiator, a heating plate, and a fan arranged sequentially from top to bottom, with the fan's air outlet facing the other side of the support plate; the temperature control mechanism includes a heat exchange gas inlet block and an inlet pipe connector, the heat exchange gas inlet block being disposed inside the housing, and the inlet pipe connector being disposed outside the housing, the heat exchange gas inlet block including an inlet and several outlets communicating with the inlet; one end of the inlet pipe connector is used to connect to the cooling system, and the other end is used to connect to the inlet of the heat exchange gas inlet block;

[0033] Alternatively, the temperature control mechanism may also include a temperature equalization fan, which is disposed on the side wall of the chamber. Its advantages lie in that by placing the heat exchange mechanism and temperature control mechanism below the other side of the tray, it facilitates the adjustment of the temperature at the bottom of the reagent kit. By setting the temperature control mechanism to include a controller and a temperature sensor, and electrically connecting the heat exchange mechanism, temperature control mechanism, and temperature sensor to the controller, precise temperature control within the chamber can be achieved. The heat exchange mechanism includes a radiator, a heating plate, and a fan arranged sequentially from top to bottom, with the fan's outlet facing the other side of the tray. The temperature control mechanism includes a heat exchange gas inlet block and an inlet pipe connector. The heat exchange gas inlet block is disposed inside the chamber, and the inlet pipe connector is disposed outside the chamber. The heat exchange gas inlet block includes an inlet and several outlets communicating with the inlet, facilitating the adjustment of the temperature at the bottom of the reagent kit. The temperature control mechanism also includes a temperature equalization fan, which is disposed on the side wall of the chamber, ensuring that the temperature remains consistent throughout the entire chamber. Attached Figure Description

[0034] Figure 1 A three-dimensional structural diagram of a reagent kit base provided for an embodiment of this utility model;

[0035] Figure 2 A top view of a tray of a reagent kit base provided in an embodiment of this utility model;

[0036] Figure 3 A bottom view of a tray of a reagent kit base provided in an embodiment of this utility model;

[0037] Figure 4 An assembly diagram of a reagent kit base, including the tray, rotating connector, and sliding connector, provided for an embodiment of this utility model;

[0038] Figure 5 A top view of a reagent kit provided in an embodiment of this utility model;

[0039] Figure 6 A schematic cross-sectional view of a reagent kit base tray and a reagent kit provided for an embodiment of this utility model;

[0040] Figure 7 for Figure 6 A magnified view of part A in the image;

[0041] Figure 8 An assembly diagram of a reagent kit base, slide rail, and movable seat provided for an embodiment of this utility model;

[0042] Figure 9 A schematic diagram of the assembly structure of another reagent kit base, slide rail, and movable seat provided in this embodiment of the utility model.

[0043] Figure 10 This is a schematic diagram of the internal structure of a temperature control device provided in an embodiment of the present utility model.

[0044] Explanation of reference numerals in the attached figures:

[0045] 1. Tray; 2. Reagent kit; 3. Rotating connector; 4. Sliding connector; 5. Heat exchange mechanism; 6. Temperature control mechanism; 7. Chamber; 8. Heat spreader; 9. Slide rail; 10. Movable base;

[0046] 11. Loading area; 12. Card slot; 13. Temperature exchange slot; 14. Heat-conducting plate; 15. Temperature exchange space; 16. Heat exchange through hole; 17. First mounting position; 18. Second mounting position;

[0047] 21. Box body; 22. Sample dispensing port;

[0048] 51. Radiator; 52. Heating plate; 53. Fan;

[0049] 61. Heat exchange gas inlet block; 62. Connecting pipe joint. Detailed Implementation

[0050] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions in the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model. Unless otherwise defined, the technical or scientific terms used herein should have the ordinary meaning understood by one of ordinary skill in the art to which this utility model pertains. The terms "comprising" and similar expressions used herein mean that the element or object preceding the word covers the element or object listed following the word and its equivalents, but does not exclude other elements or objects.

[0051] To address the inconvenience of current reagent kit bases, the reagent kit base provided by this utility model utilizes a heat-conducting sheet to increase the heat conduction efficiency of the loading area, improving the timeliness of temperature adjustment of the bottom of the reagent kit by the loading area, ensuring that the temperature of the bottom area of ​​the reagent kit is synchronized with other areas, thereby achieving uniform heating of the entire reagent kit. The technical solutions of the embodiments of this utility model are described below with reference to the accompanying drawings. In the description of the embodiments of this utility model, the terminology used in the following embodiments is for the purpose of describing specific embodiments only and is not intended to be a limitation of this utility model. The singular expressions "a," "the," "the," "the," and "this" are intended to also include expressions such as "one or more," unless the context clearly indicates otherwise. It should also be understood that in the following embodiments of this utility model, "at least one" and "one or more" refer to one or more (including two). The term "and / or" is used to describe the relationship between related objects, indicating that three relationships can exist; for example, A and / or B can indicate: A alone, A and B simultaneously, or B alone, where A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship.

[0052] References to "one embodiment" or "some embodiments" in this specification mean that one or more embodiments of the present invention include a specific feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in one embodiment," "in some embodiments," "in other embodiments," and "in still other embodiments" appearing in different parts of this specification do not necessarily refer to the same embodiment, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized. The terms "comprising," "including," "having," and variations thereof mean "including, but not limited to," unless otherwise specifically emphasized. The term "connection" includes both direct and indirect connections, unless otherwise stated. "First" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated.

[0053] In the embodiments of this utility model, "exemplarily" or "for example" are used to indicate examples, illustrations, or descriptions. Any embodiment or design described as "exemplarily" or "for example" in the embodiments of this utility model should not be construed as being more preferred or advantageous than other embodiments or design solutions. Specifically, the use of "exemplarily" or "for example" is intended to present the relevant concepts in a specific manner.

[0054] The heat exchange medium in this article refers to the medium used for heat exchange, such as solid, liquid or gas. When the reagent kit base exchanges heat with the heat exchange mechanism through direct contact, the heat exchange mechanism is also a solid heat exchange medium.

[0055] like Figure 1-3 As shown, this utility model provides a reagent kit base, which includes a tray 1. One side of the tray 1 is provided with a plurality of loading areas 11 for carrying reagent kits 2. At least one loading area 11 is provided on the other side of the tray 1 with a heat-conducting sheet 14. The heat-conducting sheet 14 is used to conduct heat exchange medium to control the temperature of the reagent kit 2. Compared with existing reagent kit bases with poor thermal conductivity, this utility model enhances the thermal conductivity of the loading area 11 by using the heat-conducting sheet 14 to conduct heat or cold from the other side of the tray 1 to the side where the loading area 11 is located. This improves the heating or cooling of the bottom of the reagent kit 2 in the loading area 11, improves the timeliness of temperature adjustment of the bottom of the reagent kit 2 by the loading area 11, and keeps the temperature of the bottom area of ​​the reagent kit 2 synchronized with other areas, thereby achieving uniform heating of the entire reagent kit 2. It is worth noting that the number of loading areas 11 can be adjusted according to actual needs, and the size and shape of the loading areas 11 are set according to the actual size and shape of the reagent kit 2 to be placed.

[0056] Preferably, the heat or cold comes from hot air or cold air.

[0057] In one example, there are two loading areas 11, and they are rectangular in shape. Preferably, the two loading areas 11 are symmetrically arranged on the pallet 1. When the number of loading areas 11 is odd, all loading areas 11 can be evenly distributed on the pallet 1.

[0058] In some embodiments, to further ensure temperature synchronization between the bottom region of the sample well 22 and other regions of the sample well 22, and to ensure uniform heating of the reagent in the sample well 22, such as... Figure 1 As shown, the surface of the tray 1 within the loading area 11 is also provided with a temperature exchange tank 13 for placing sample dispensing wells 22 of the reagent kit 2. Each row of sample dispensing wells 22 corresponds to one temperature exchange tank 13. The temperature exchange tank 13 is used to receive the heat conducted by the heat-conducting sheet 14 and evenly distribute it on the surface of the temperature exchange tank 13. It is worth noting that in the reagent kit 2, "row" refers to a collection of reagent units or wells arranged horizontally, and "column" refers to a collection of units or wells arranged vertically. For example, in a 96-well plate of reagent kit 2, there are usually 8 rows and 12 columns, totaling 96 wells. Here, "row" can be understood as "row," that is, 12 wells arranged horizontally form a row, with a total of 8 rows; or adjacent wells of the same size are grouped into a column, for example, with Figure 5 As shown, there is a row from left to right and a column from top to bottom.

[0059] In other embodiments, to avoid localized overheating / overcooling caused by direct contact, such as Figure 6 As shown, the temperature exchange groove 13 is configured not to contact the bottom area of ​​the sample dispensing port 22. In some specific embodiments, to ensure temperature control efficiency while avoiding interference with the local temperature of the sample dispensing port 22 due to direct contact, the distance between the temperature exchange groove 13 and the bottom area of ​​the sample dispensing port 22 is set to 0.1-3 mm. In still other specific embodiments, to further improve temperature control efficiency and avoid interference with the local temperature of the sample dispensing port 22, the distance between the temperature exchange groove 13 and the bottom area of ​​the sample dispensing port 22 is set to 0.2-1 mm. Figure 7 As shown, a is the point on the surface of the temperature exchange bath 13 closest to the bottom of the sample feeding hole 22, and b is the point on the surface of the temperature exchange bath 13 farthest from the bottom of the sample feeding hole. Therefore, 0.1≤a / b≤3 mm, or 0.2≤a / b≤1 mm.

[0060] In some embodiments, for ease of loading and unloading of reagent kit 2 and for convenient use, such as... Figure 1 and 2 As shown, the edge of the loading area 11 is provided with a slot 12 that is adapted to the box 21 of the reagent kit 2, and the box 21 of the reagent kit 2 and the slot 12 are engaged and connected.

[0061] In some specific embodiments, in order to further improve the temperature synchronization between the lower region of the sample well 22 and other regions of the sample well 22, and to ensure uniform heating of the entire reagent kit 2, such as... Figure 1 As shown, the sample dispensing port 22 of the reagent kit 2 is disposed in the housing 21, and the slot 12 and the housing 21 cooperate to form a temperature exchange space 15 surrounding at least the lower region of the sample dispensing port 22 of the reagent kit 2. In one example, as... Figure 6 As shown, the surface of the loading area 11 on the tray 1 is slightly lower than the surface of other areas, which facilitates the formation of a relatively large temperature exchange space 15 between the loading area 11 and the bottom of the reagent kit 2, thereby improving the temperature stability of the temperature exchange space 15.

[0062] In some embodiments, to ensure that the bottom region of reagent kit 2 maintains temperature synchronization with other regions, and to make the entire reagent kit 2 heat more evenly, such as... Figure 1 As shown, the tray 1 in the loading area 11 is also provided with heat exchange through holes 16 to allow the heat exchange medium to flow into the loading area 11.

[0063] In some embodiments, to improve the efficiency of heat flow in the loading area 11 and make the entire reagent kit 2 more uniformly heated, the heat exchange through-hole 16 includes one or more of the following features: (1) the number of heat exchange through-holes 16 is plurality of; (2) the shape of the heat exchange through-hole 16 is strip-shaped; (3) the extending direction of the heat exchange through-hole 16 is the same as the extending direction of the side of the loading area 11 in which it is located. In one example, such as Figure 3 As shown, there are four heat exchange through holes 16, all of which are strip-shaped and are respectively arranged on the four sides of the rectangular loading area 11, and in the same direction of extension as each side. In addition, it is worth noting that the length and width of the heat exchange through holes 16 on different sides can be adjusted according to actual needs. Preferably, the length of the heat exchange through holes 16 arranged on the long side of the rectangular loading area 11 is longer than that of the heat exchange through holes 16 arranged on the short side of the rectangular loading area 11, and the width of the heat exchange through holes 16 arranged on the short side of the rectangular loading area 11 is wider than that of the heat exchange through holes 16 arranged on the long side of the rectangular loading area 11.

[0064] In some embodiments, to improve the heating efficiency of the bottom of the sample feeding port 22, such as Figure 7 As shown, the temperature exchange groove 13 is composed of strip-shaped protrusions spaced apart on the tray 1. In some specific embodiments, in order to concentrate heat and improve heat utilization efficiency, the bottom cross-section of the strip-shaped protrusion is larger than its top cross-section. In other specific embodiments, in order to achieve uniform heating of the bottom of the sample dispensing hole 22, the side of the strip-shaped protrusion is set to be an arc-shaped surface. Preferably, in order to further ensure the temperature consistency at all points at the bottom of the sample dispensing hole 22, the curvature of the arc-shaped surface is adapted to the curvature of the bottom of the sample dispensing hole 22.

[0065] In some embodiments, to concentrate heat and improve thermal conductivity, the number of heat-conducting plates 14 is multiple, such as... Figure 1 As shown, two adjacent heat-conducting sheets 14 are arranged side-by-side with a gap to form a heat-conducting groove. In some specific embodiments, in order to achieve uniform heat conduction and ensure that the temperature remains consistent throughout the loading area 11, the spacing between all the heat-conducting sheets 14 is set to be the same.

[0066] In other specific embodiments, such as Figure 1As shown, the heat-conducting groove includes a combination of any one or more of the following features: (1) the straight line containing the length of the heat-conducting groove is parallel to the straight line containing the length of the heat exchange groove 13; (2) the depth of the heat-conducting groove is greater than the depth of the heat exchange groove 13; (3) the width of the heat-conducting groove is less than the width of the heat exchange groove 13; (4) the number of heat-conducting grooves is greater than the number of heat exchange grooves 13. In one example, setting the straight line containing the length of the heat-conducting groove to be parallel to the straight line containing the length of the heat exchange groove 13 improves the efficiency of heat transfer to the heat exchange groove 13. Setting the depth of the heat-conducting groove to be greater than the depth of the heat exchange groove 13, the width of the heat-conducting groove to be less than the width of the heat exchange groove 13, or the number of heat-conducting grooves to be greater than the number of heat exchange grooves 13 improves the heat collection capacity of the heat-conducting groove, thereby improving the heating efficiency of the heat exchange groove 13 to the bottom of the sample feeding hole 22.

[0067] In some embodiments, to achieve uniform heating and shaking of the reagents in kit 2 to ensure complete reaction, such as... Figure 2 As shown, the tray 1 is provided with a first mounting position 17 for mounting the rotating connector 3 and a second mounting position 18 for mounting the sliding connector 4. The rotating connector 3 is used to rotatably connect the tray 1 and the corresponding movable seat 10 for moving the tray. The sliding connector 4 is used to slidably connect the tray 1 and the corresponding slide rail 9. The slide rail 9 has at least one undulating section in the moving direction of the tray 1. During the movement of the sliding connector 4 along the slide rail 9, the tray 1 tilts by driving the tray 1 to rotate relative to the movable seat 10. It is worth noting that when both the sliding connector 4 and the rotating connector 3 are provided on the tray 1, the tray 1 can tilt by rotating relative to the slide rail 9 while moving. For example, the sliding connector 4 can be slidably connected to the slide rail 9; or the movable seat 10 can be provided, and the tray 1 and the movable seat 10 can be rotatably connected by the rotating connector 3. In one example, the rotating connector 3 is used for rotatably connecting the tray 1 and the corresponding movable seat 10; the sliding connector 4 is used for slidably connecting the tray 1 and the corresponding slide rail 9; the rotating connector 3 and the sliding connector 4 are spaced apart along the horizontal axis of the moving direction of the tray 1; the slide rail 9 has an undulating section in the moving direction, and as the sliding connector 4 moves along the slide rail 9, it causes the tray 1 to tilt relative to the movable seat 10 by driving the tray 1 to rotate, thereby shaking the reagent kit 2 carried on the tray 1. The undulating section refers to a section of the slide rail 9 with a height difference at both ends, and the position of the slide rail 9 can be set on the left and right sides of the moving direction of the tray (e.g., Figure 8 As shown), directly above (as shown) Figure 9 (as shown) or directly below.

[0068] Based on the above reagent kit base, such as Figure 10 As shown, this utility model also provides a reagent kit temperature control device, which includes a reagent kit base and a heat exchange mechanism 5; the heat exchange mechanism 5 is disposed below the other side of the tray 1 of the base, preferably, there is a certain distance between the heat exchange mechanism and the tray 1.

[0069] A heat exchange mechanism is a device that provides a source of heat exchange medium.

[0070] In one embodiment, the temperature control device further includes a temperature adjustment mechanism 6, a temperature control mechanism (not shown), and a housing 7. The base is disposed within the housing 7, and the temperature adjustment mechanism 6 is disposed below the other side of the tray 1 of the base. The temperature adjustment mechanism 6 also serves as a source of heat exchange medium. The temperature control mechanism controls the heat exchange mechanism 5 and the temperature adjustment mechanism 6 to regulate the temperature within the housing 7. By placing the reagent kit base within the housing 7, and controlling the heat exchange mechanism 5 and the temperature adjustment mechanism 6 in conjunction to regulate and monitor the temperature within the housing 7 through the temperature control mechanism, the temperature control efficiency is high, temperature fluctuations are avoided, and constant temperature preservation and reaction of the reagents in the reagent kit 2 are achieved. Furthermore, the use of the tray 1 with the heat-conducting plate 14 improves the timeliness of temperature adjustment of the reagent kit 2, ensuring that the temperature of the bottom area of ​​the reagent kit 2 remains synchronized with other areas, thereby achieving uniform heating of the entire reagent kit 2. One side of the housing 7 has an opening with a door (not marked) for inserting or removing the reagent kit 2 into the housing 7.

[0071] In some embodiments, to achieve precise temperature control within the enclosure 7, the temperature control mechanism includes a controller (not shown) and a temperature sensor (not shown). The heat exchange mechanism, temperature adjustment mechanism 6, and temperature sensor are electrically connected to the controller. It is worth noting that the temperature sensor is located inside the enclosure 7 to monitor the temperature inside the enclosure 7, while the controller can be located either inside or outside the enclosure 7.

[0072] In some specific embodiments, to facilitate temperature adjustment at the bottom of the reagent kit 2, the heat exchange mechanism includes a radiator 51, a heating plate 52, and a fan 53 arranged sequentially from top to bottom, with the air outlet of the fan 53 facing the other side of the tray 1; the temperature control mechanism 6 includes a heat exchange gas inlet block 61 and an inlet pipe connector 62, the heat exchange gas inlet block 61 being disposed inside the housing 7, and the inlet pipe connector 62 being disposed outside the housing 7, the heat exchange gas inlet block 61 including an inlet and several outlets communicating with the inlet; one end of the inlet pipe connector 62 is used to connect to the heat exchange supply system, and the other end is used to connect to the inlet of the heat exchange gas inlet block 61.

[0073] In some specific embodiments, to maintain a consistent temperature throughout the entire enclosure 7, such as... Figure 10 As shown, the temperature control mechanism also includes a temperature equalization fan 8, which is disposed on the side wall of the housing 7. In one example, the heat exchange mechanism 5 is disposed near the bottom of the housing 7, the heat exchange gas inlet blocks 61 are respectively disposed on the left and right side walls of the housing 7, and the temperature equalization fan 8 is disposed on the side wall of the housing 7 away from the opening of the housing 7.

[0074] The working process of the temperature control device of this utility model is as follows: When in use, open the door of the chamber 7, place the reagent kit 2 in the corresponding loading area 11 on the tray 1 through the slot 12, and form a temperature exchange space 15 in the lower area of ​​the sample dispensing hole 22 of the reagent kit 2. Then close the door of the chamber 7. The temperature control mechanism controls the heat exchange mechanism 5 and the temperature adjustment mechanism 6 to adjust the temperature of the entire chamber 7 to the set temperature. The operation of the temperature equalization fan 8 can make the temperature of the entire chamber 7 uniform. When heating, the heating plate 52 of the heat exchange mechanism generates heat, which is blown to the bottom of the tray 1 by the radiator 51 and the fan 53. Some of the heat is conducted to the temperature exchange space by the heat conduction plate 14. The heat from the heat exchanger 13 enters the heat exchange space 15 through the heat exchange through hole 16, which helps to uniformly heat the bottom of the reagent kit 2. When cooling down, the external cooling system generates cold air, which enters the inlet of the heat exchange gas inlet block 61 through the inlet pipe connector 62 of the temperature control mechanism, passes through the internal pipe of the heat exchange gas inlet block 61, and enters the box 7 through each outlet of the heat exchange gas inlet block 61. The bottom of the sample dispensing hole 22 of the reagent kit 2 is uniformly cooled by the heat-conducting plate 14 and the heat exchange through hole 16. The temperature control mechanism, the heat exchange mechanism and the temperature control mechanism 6 work together to control the temperature of the reagent in the reagent kit 2 in the box 7.

[0075] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent modifications made based on the content of this utility model specification and drawings, or direct or indirect applications in related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A kit base, characterized in that, The base comprises a tray, one side of the tray is provided with a plurality of loading areas for carrying reagent boxes; At least one of the loading areas is provided with a heat conduction sheet on the other side of the corresponding tray; The heat conduction sheet is used for conducting heat exchange medium to heat exchange and temperature control of the reagent box.

2. The base of claim 1, wherein, The surface of the tray in the loading area is further provided with a temperature exchange groove for placing the sample adding hole of the reagent box.

3. A base as claimed in claim 1 or 2, characterised in that, The edge of the loading area is provided with a clamping groove matched with the box body of the reagent box.

4. The base of claim 1, wherein, The tray in the loading area is further provided with a heat exchange through hole to allow the heat exchange medium to flow into the loading area.

5. The base of claim 4, wherein, The heat exchange through hole comprises one or more of the following features: (1) The number of heat exchange through holes is multiple; (2) The shape of the heat exchange through hole is strip-shaped; (3) The extension direction of the heat exchange through hole is the same as the extension direction of the side of the loading area.

6. The base of claim 2, wherein, The temperature exchange groove is composed of strip-shaped protrusions arranged at intervals on the tray.

7. The base of claim 1, wherein The number of heat conduction sheets is multiple, and two adjacent heat conduction sheets are arranged at intervals and side by side to form a heat conduction groove.

8. The base of claim 7, wherein, The heat conduction groove comprises any one or more combinations of the following features: (1) The length of the heat conduction groove is parallel to the length of the temperature exchange groove; (2) The depth of the heat conduction groove is greater than the depth of the temperature exchange groove; (3) The width of the heat conduction groove is less than the width of the temperature exchange groove; (4) The number of heat conduction grooves is greater than the number of temperature exchange grooves.

9. The base of claim 1, wherein, The tray is provided with a first mounting position for mounting a rotating connecting member and a second mounting position for mounting a sliding connecting member; The rotating connecting member is used for rotating connection of the tray and a corresponding moving seat for moving the tray; The sliding connecting member is used for sliding connection of the tray and a corresponding slide rail; The slide rail has at least one undulating section in the moving direction of the tray, and in the process of moving the sliding connecting member along the slide rail, the tray is tilted by driving the tray to rotate relative to the moving seat.

10. The base of claim 2, wherein, Each row of sample adding holes corresponds to a temperature exchange groove.

11. The base of claim 2, wherein, The temperature exchange groove does not contact the bottom area of the sample adding hole.

12. The base of claim 11, wherein, The distance between the temperature exchange groove and the bottom area of the sample adding hole is 0.1-3mm.

13. The base of claim 12, wherein, The distance between the temperature exchange groove and the bottom area of the sample adding hole is 0.2-1mm.

14. The base of claim 3, wherein, The sample adding hole of the reagent box is arranged in the box body, and the clamping groove and the box body are matched to surround at least the lower area of the sample adding hole to form a temperature exchange space.

15. The base of claim 6, wherein, The bottom cross-sectional size of the strip-shaped protrusion is greater than the top cross-sectional size thereof; and / or the side surface of the strip-shaped protrusion is an arc surface.

16. The base of claim 15, wherein, The curvature of the arc surface is matched with the curvature of the bottom of the sample adding hole.

17. The base of claim 7, wherein, The intervals between all the heat conduction sheets are the same.

18. A kit temperature control apparatus, characterized by, The reagent box base and the heat exchange mechanism of any one of claims 1-17 are included; the heat exchange mechanism is arranged below the other side of the tray of the base.

19. The temperature-controlled device of claim 18, wherein, Further comprising a temperature adjusting mechanism, a temperature control mechanism and a box body, the base is arranged in the box body, the temperature adjusting mechanism is arranged below the other side of the tray of the base, and the temperature control mechanism controls the temperature adjusting mechanism and the temperature control mechanism to adjust the temperature in the box body.

20. The temperature-controlled device of claim 19, wherein, The heat exchange mechanism, the temperature adjusting mechanism and the temperature detecting sensor are electrically connected with the controller.

21. The temperature-controlled device of claim 20, wherein, The heat exchange mechanism comprises a radiator, a heating plate and a fan arranged in sequence from top to bottom, and the air outlet of the fan faces the other side of the supporting plate; the temperature adjusting mechanism comprises a heat exchange gas inlet block and a connecting pipe joint, the heat exchange gas inlet block is arranged in the box, the connecting pipe joint is arranged outside the box, the heat exchange gas inlet block comprises an inlet and a plurality of outlets in communication with the inlet; one end of the connecting pipe joint is used for connecting a cooling system, and the other end is used for connecting the inlet of the heat exchange gas inlet block.

22. The temperature-controlled device of claim 20, wherein, The temperature adjusting mechanism further comprises a temperature equalizing fan, and the temperature equalizing fan is arranged on the side wall of the box.

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