Dapagliflozin preparation reaction device with protection function

Abstract

The utility model discloses a dapagliflozin preparation reaction device with a protection function, and relates to the technical field of chemical medicine production equipment. Comprising a reaction kettle body, a protection part is rotatably arranged in an inner cavity of the reaction kettle body, a main material enters the reaction kettle body through a main material pipe, an ingredient enters an ingredient barrel in the reaction kettle body through an ingredient pipe, and at the moment, a sealing disc is tightly attached to the bottom of an inner cavity of the ingredient barrel to seal the bottom of the ingredient barrel. The main material and the auxiliary material do not react immediately, so that the material and the auxiliary material are prevented from violently reacting to generate material flushing, and liquid medicine in the reaction kettle body is prevented from being sprayed out through the auxiliary material pipe and the main material pipe to injure personnel.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of chemical and pharmaceutical production equipment, specifically to a reaction device with protection function for dapagliflozin preparation. BACKGROUND

[0002] Dapagliflozin (dapagliflozin, ForxigaTM) chemical name is (2S, 3R, 4R, 5S, 6R)-2-[3-(4-ethoxyphenyl)-4-chlorophenyl]-6-hydroxymethyl tetrahydro-2H-pyran-3, 4, 5-triol.

[0003] In the process of dapagliflozin preparation, the reaction kettle is needed to be used to mix the liquid medicine, when the liquid medicine is added by mistake, the liquid medicine in the inner cavity of the reaction kettle is easy to react violently and cause material to be ejected, which causes the liquid medicine in the inner cavity of the reaction kettle to be ejected through the feed pipe and cause harm to personnel.

[0004] Therefore, we improve it and propose a reaction device with protection function for dapagliflozin preparation. UTILITY MODEL CONTENT

[0005] In view of the deficiencies of the prior art, the utility model provides a reaction device with protection function for dapagliflozin preparation, which solves the problem that when the liquid medicine is added by mistake, the liquid medicine in the inner cavity of the reaction kettle is easy to react violently and cause material to be ejected, which causes the liquid medicine in the inner cavity of the reaction kettle to be ejected through the feed pipe and cause harm to personnel.

[0006] In order to achieve the above purpose, the utility model is realized by the following technical scheme: a reaction device with protection function for dapagliflozin preparation, comprising a reaction kettle body, a protection component is rotatably arranged in the inner cavity of the reaction kettle body, the protection component comprises a batching cylinder and a sealing disc, the batching cylinder is rotatably arranged in the lower part of the inner cavity of the reaction kettle body, and the sealing disc is longitudinally movably arranged in the inner cavity of the batching cylinder.

[0007] The bottom of the batching cylinder is provided with a plurality of uniformly distributed through holes A, the sealing disc is provided with a plurality of uniformly distributed through holes B, and the through holes A and the through holes B are arranged in an upper and lower staggered manner.

[0008] As a preferred scheme, the upper middle part of the reaction kettle body is fixedly provided with a motor, the motor is connected with a rotating shaft, and the rotating shaft is fixedly connected with the inner cavity bottom wall of the batching cylinder.

[0009] As a preferred scheme, the upper two sides of the reaction kettle body are symmetrically provided with hydraulic oil cylinders, the piston rod of the hydraulic oil cylinder is fixedly connected with a connecting rod, and the distal end of the connecting rod is fixedly and symmetrically arranged on the upper surface of the sealing disc.

[0010] As a preferred scheme, the outer wall of the ingredient cylinder is longitudinally provided with a plurality of uniformly distributed stirring plates A, which are rectangular plate structures.

[0011] As a preferred scheme, the middle part of the outer bottom wall of the ingredient cylinder is longitudinally uniformly provided with a plurality of uniformly distributed stirring plates B along the axis of the ingredient cylinder, which are fan-shaped plate structures.

[0012] As a preferred scheme, the arc surface side wall of the stirring plate B is arranged towards the bottom inner wall of the reaction kettle body.

[0013] As a preferred scheme, the upper part of the side wall of the reaction kettle body is communicated with an ingredient pipe, the ingredient pipe arranged outside the reaction kettle body is provided with a valve switch, and the mouth part of the ingredient pipe arranged in the inner cavity of the reaction kettle body is vertically arranged towards the mouth part of the ingredient cylinder.

[0014] As a preferred scheme, the lower part of the side wall of the reaction kettle body is communicated with a main material pipe, the main material pipe arranged outside the reaction kettle body is provided with a valve switch, and the mouth part of the main material pipe arranged in the inner cavity of the reaction kettle body is vertically arranged towards the middle side wall of the ingredient cylinder.

[0015] As a preferred scheme, the upper part of the reaction kettle body is communicated with a pressure relief valve, and the middle part of the outer bottom wall of the reaction kettle body is provided with a discharge pipe, which is provided with a valve switch.

[0016] The utility model has the following beneficial effects:

[0017] The main material enters the reaction kettle body through the main material pipe, and the ingredient enters the ingredient cylinder in the reaction kettle body through the ingredient pipe, at this time, the sealing disc is tightly attached to the inner cavity bottom of the ingredient cylinder, the bottom of the ingredient cylinder is closed, so that when the raw material is put into the reaction kettle body, the main material and the ingredient will not react immediately, thereby preventing the material and the ingredient from reacting violently and causing the reaction kettle body to spray the liquid medicine through the ingredient pipe and the main material pipe, which causes harm to the personnel.

[0018] Of course, any product implementing the utility model does not necessarily need to achieve all the advantages described above. BRIEF DESCRIPTION OF DRAWINGS

[0019] Fig. 1 It is a structure schematic view of the utility model of a kind of reaction device with protective function for preparing Dapagliflozin;

[0020] Fig. 2 It is a sectional structure schematic view of the utility model of a kind of reaction device with protective function for preparing Dapagliflozin;

[0021] Fig. 3 It is Fig. 2 The enlarged structure schematic view of local A;

[0022] In the figure, 1, reactor body; 2, protective component; 3, ingredient cylinder; 4, sealing disc; 5, through hole A; 6, through hole B; 7, motor; 8, rotating shaft; 9, hydraulic oil cylinder; 10, connecting rod; 11, stirring plate A; 12, stirring plate B; 13, ingredient pipe; 14, valve switch; 15, main pipe; 16, pressure relief valve; 17, discharge pipe. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0024] In the description of the present application, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "periphery" and the like indicate the orientation or positional relationship, which are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the components or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation of the present application.

[0025] Embodiments please refer to Figs. 1 to 3 The technical scheme provided by the embodiments of the present application is: a reaction device for preparing Dapagliflozin with protection function, comprising a reactor body 1, a protective component 2 is rotatably arranged in the inner cavity of the reactor body 1, the protective component 2 comprises an ingredient cylinder 3 and a sealing disc 4, the ingredient cylinder 3 is rotatably arranged in the lower part of the inner cavity of the reactor body 1, and the sealing disc 4 is longitudinally movably arranged in the inner cavity of the ingredient cylinder 3.

[0026] The bottom of the ingredient cylinder 3 is provided with a plurality of uniformly distributed through holes A 5, the sealing disc 4 is provided with a plurality of uniformly distributed through holes B 6, and the through holes A 5 and the through holes B 6 are arranged in staggered manner.

[0027] The upper middle end of the reactor body 1 is fixedly provided with a motor 7, the motor 7 is connected with a rotating shaft 8, the rotating shaft 8 is fixedly connected with the middle part of the inner cavity bottom wall of the ingredient cylinder 3, and the rotating shaft 8 penetrates through the middle of the ingredient cylinder 3.

[0028] The upper two sides of the reactor body 1 are symmetrically provided with hydraulic oil cylinders 9, the piston rods of the hydraulic oil cylinders 9 are fixedly connected with connecting rods 10, and the distal ends of the connecting rods 10 are fixedly and symmetrically arranged on the upper surface of the sealing disc 4.

[0029] A plurality of uniformly distributed stirring plates A 11 are longitudinally arranged on the outer wall of the ingredient cylinder 3, and the stirring plates A 11 are rectangular plate structures.

[0030] The middle part of the outer bottom wall of the ingredient cylinder 3 is longitudinally and uniformly provided with a plurality of uniformly distributed stirring plates B12 in the form of fan-shaped plates.

[0031] The arc side wall of the stirring plate B12 is arranged towards the bottom inner wall of the reaction kettle body 1.

[0032] The upper part of the side wall of the reaction kettle body 1 is communicated with an ingredient pipe 13, the ingredient pipe 13 arranged outside the reaction kettle body 1 is provided with a valve switch 14, and the mouth of the ingredient pipe 13 arranged in the inner cavity of the reaction kettle body 1 is vertically arranged towards the mouth of the ingredient cylinder 3.

[0033] The lower part of the side wall of the reaction kettle body 1 is communicated with a main material pipe 15, the main material pipe 15 arranged outside the reaction kettle body 1 is provided with a valve switch 14, and the mouth of the main material pipe 15 arranged in the inner cavity of the reaction kettle body 1 is vertically arranged towards the middle side wall of the ingredient cylinder 3.

[0034] The upper part of the reaction kettle body 1 is communicated with a pressure relief valve 16, the middle part of the outer bottom wall of the reaction kettle body 1 is provided with a discharge pipe 17, and the discharge pipe 17 is provided with a valve switch 14.

[0035] The working principle of the utility model is as follows:

[0036] The main material enters the reaction kettle body 1 through the main material pipe 15, and the ingredient enters the ingredient cylinder 3 in the reaction kettle body 1 through the ingredient pipe 13, at this time, the sealing disc 4 is tightly attached to the inner cavity bottom of the ingredient cylinder 3, the bottom of the ingredient cylinder 3 is closed, so that when the raw materials are put into the reaction kettle body 1, the main material and the ingredient will not react immediately, thereby preventing the violent reaction of the material and the ingredient and causing the material to be ejected through the ingredient pipe 13 and the main material pipe 15 to cause harm to the personnel.

[0037] Then the motor 7 is started, the ingredient cylinder 3 is driven to rotate, the hydraulic oil cylinder 9 lifts the sealing disc 4 through the connecting rod 10, the ingredient is discharged through the through hole A5 and the through hole B6, and the ingredient and the main material are stirred through the stirring plate A11 and the stirring plate B12, so that the ingredient and the main material are reacted. The pressure relief valve 16 can effectively control the pressure in the reaction kettle body 1, prevent the pressure in the reaction kettle body 1 from being too large, and cause safety accidents.

[0038] It is to be noted that the relational terms herein, such as first and second, and the like, are used solely to distinguish one from another entity or action without necessarily requiring or implying any actual relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can also include other elements not expressly listed or inherent to such process, method, article, or apparatus.

[0039] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details and limit the utility model to the specific embodiments described. Obviously, according to the content of the specification, many modifications and changes can be made. The specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that the persons skilled in the art can well understand and use the utility model. The utility model is limited by the claims and the entire scope and equivalents thereof.

Claims

1. A reaction apparatus for preparing dapagliflozin with protective functions, characterized in that: The reactor body (1) includes a protective component (2) that is rotatably provided in the inner cavity of the reactor body (1). The protective component (2) includes a dispensing cylinder (3) and a sealing plate (4). The dispensing cylinder (3) is suspended and rotatably disposed in the lower part of the inner cavity of the reactor body (1), and the sealing plate (4) is longitudinally moved and disposed in the inner cavity of the dispensing cylinder (3). The bottom of the mixing cylinder (3) is provided with multiple evenly distributed through holes A (5), and the sealing disc (4) is provided with multiple evenly distributed through holes B (6). The through holes A (5) and through holes B (6) are arranged in an alternating vertical arrangement.

2. The reaction apparatus for preparing dapagliflozin with protective function according to claim 1, characterized in that: The upper middle part of the reactor body (1) is fixedly provided with a motor (7), the motor (7) is connected to a rotating shaft (8), and the rotating shaft (8) is fixedly connected to the middle part of the inner cavity bottom wall of the mixing cylinder (3).

3. The reaction apparatus for preparing dapagliflozin with protective function according to claim 1, characterized in that: Hydraulic cylinders (9) are symmetrically arranged on both sides of the upper part of the reactor body (1). The piston rod of the hydraulic cylinder (9) is fixedly connected to a connecting rod (10). The end of the connecting rod (10) is fixedly and symmetrically arranged on the upper surface of the sealing plate (4).

4. The reaction apparatus for preparing dapagliflozin with protective function according to claim 1, characterized in that: The outer wall of the mixing cylinder (3) is provided with multiple uniformly distributed stirring plates A (11), and the stirring plates A (11) are rectangular plates.

5. The reaction apparatus for preparing dapagliflozin with protective function according to claim 1, characterized in that: The outer bottom wall of the mixing cylinder (3) is provided with a plurality of uniformly distributed stirring plates B (12) along the longitudinal axis of the mixing cylinder (3). The stirring plates B (12) are fan-shaped plate structures.

6. The reaction apparatus for preparing dapagliflozin with protective function according to claim 5, characterized in that: The arc-shaped sidewall of the stirring plate B (12) is set towards the bottom inner wall of the reactor body (1).

7. The reaction apparatus for preparing dapagliflozin with protective function according to claim 1, characterized in that: The upper side wall of the reactor body (1) is connected to a feeding pipe (13). The feeding pipe (13) located outside the reactor body (1) is equipped with a valve switch (14). The opening of the feeding pipe (13) located inside the reactor body (1) is vertically facing the opening of the feeding cylinder (3).

8. The reaction apparatus for preparing dapagliflozin with protective function according to claim 1, characterized in that: The lower side wall of the reactor body (1) is connected to a main feed pipe (15). The main feed pipe (15) located outside the reactor body (1) is equipped with a valve switch (14). The opening of the main feed pipe (15) located inside the reactor body (1) is vertically facing the middle side wall of the mixing cylinder (3).

9. A reaction apparatus for preparing dapagliflozin with protective function according to claim 1, characterized in that: The upper part of the reactor body (1) is connected to a pressure relief valve (16), and the middle part of the outer bottom wall of the reactor body (1) is provided with a discharge pipe (17), and the discharge pipe (17) is provided with a valve switch (14).

Images