Tumor drug delivery experimental device based on microfluidics

Abstract

The utility model discloses a tumor drug delivery experiment device based on microfluidics, and belongs to the field of medical experiment instruments. Comprising a shell with a door plate hinged to one side; a syringe; a mounting rack; the micro-fluidic chip is fixedly arranged in the shell; the mixing tank is arranged in the shell and located on the lower side of the mounting frame, and the liquid outlet end of the first injector and the liquid outlet end of the second injector are both connected with the mixing tank through pipelines; the mixing cavity is arranged in the mixing tank; the stirring impeller is rotationally arranged in the mixing cavity. The tumor drug delivery experimental device based on micro-fluidic has the beneficial effects that different drugs can be delivered to the micro-fluidic control chip through the arranged first injector and the second injector, and meanwhile, through the arranged mixing assembly, the drug delivery efficiency is improved, and the drug delivery efficiency is improved. Therefore, the medicines can be conveyed to the bit flow control chip or the medicines are mixed and then conveyed to the micro-flow control chip, and the use is more flexible.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical experiment apparatuses, in particular to a tumor drug delivery experiment device based on microfluidics. BACKGROUND

[0002] Microfluidics refers to a system for processing or manipulating microfluids (volume of picoliter to nanoliter) using microchannels (size of tens to hundreds of microns). The existing drug needs to be accurately delivered to the tumor area through the microchannel during the experiment to achieve sufficient drug effect and accurate control of the drug amount. However, during drug delivery, multiple drugs may need to be delivered simultaneously, and the existing flow control generally uses a microfluidic chip. The output port of the syringe is connected to the liquid inlet end of the microfluidic chip. When multiple drugs need to be mixed and delivered, the drugs are usually mixed in the syringe and then delivered to the flow control chip. However, some drugs cannot be mixed and stored for a long time, so multiple syringes are generally used to store different drugs and are connected to the liquid inlet end of the microfluidic chip.

[0003] To solve the problem of inconvenient delivery of multiple drugs, the liquid inlet end of the microfluidic chip is usually connected to an inlet pipe, the inlet pipe has multiple connectors, and the multiple connectors are simultaneously connected to the syringes. Valves are arranged between the connectors and the connectors. When the corresponding drug needs to be injected, the corresponding valve is opened for injection. However, when multiple drugs need to be input simultaneously, the drugs will stratify in the inlet pipe, which cannot be fully mixed.

[0004] Therefore, a tumor drug delivery experiment device based on microfluidics is needed to solve the above problems. CONTENT OF THE INVENTION

[0005] The content part of the present application is used to introduce the concept in a simple form, which will be described in detail in the specific embodiment part. The content part of the present application is not intended to identify the key features or essential features of the claimed technical solution, nor is it intended to limit the scope of the claimed technical solution.

[0006] To solve the technical problems mentioned in the background section, some embodiments of the present application provide a microfluidic-based tumor drug delivery experiment device, which comprises: a shell having a door plate hinged on one side; two syringes are arranged in the shell, including a first syringe and a second syringe, and the first syringe and the second syringe are respectively provided with a first drug and a second drug; a mounting bracket for mounting the syringes; a microfluidic chip fixedly arranged in the shell, and the drug is introduced into the microfluidic chip through the syringes; a mixing assembly arranged in the shell, and the drug enters the microfluidic chip after passing through the mixing assembly, the mixing assembly is provided with a first hose for delivering the first drug to the microfluidic chip, a second hose for delivering the second drug to the microfluidic chip, and a third hose for delivering the mixed drug to the microfluidic chip; the mixing assembly comprises: a mixing tank arranged in the shell and located below the mounting bracket, the liquid outlet ends of the first syringe and the second syringe are connected to the mixing tank through pipelines; a mixing chamber arranged in the mixing tank for mixing the drug, the mixing chamber is connected to the third hose; a stirring impeller rotatably arranged in the mixing chamber for mixing the drug; an electromagnetic valve is arranged on the first hose, the second hose, and the third hose; wherein the syringe comprises a piston portion and a liquid outlet end arranged at the lower end of the piston portion, and the piston portion has a piston rod for pushing.

[0007] The electromagnetic valve can control the communication of the first hose, the second hose, and the third hose. When it is needed to deliver a single drug to the microfluidic chip, the electromagnetic valve controls the third hose to be closed, so that the drug cannot enter the mixing chamber. When it is needed to deliver a mixed drug to the microfluidic chip, the electromagnetic valve controls the first hose and the second hose to be closed, so that the first drug and the second drug flow into the mixing chamber and are mixed. The first syringe and the second syringe can deliver different drugs to the microfluidic chip. The mixing assembly can deliver the drugs to the microfluidic chip respectively or deliver the mixed drugs to the microfluidic chip. The use is flexible. The mixing chamber and the stirring impeller can fully mix the drug in the mixing chamber. The first hose, the second hose, and the third hose can output the drug respectively.

[0008] Further, the mixing tank is provided with a first channel connected to the liquid outlet end of the first syringe, and one end of the first channel is divided into two first flow channels, one of which extends to the mixing chamber, and the other of which is connected to the first hose.

[0009] The two first flow channels can make the drug flow into the mixing chamber for mixing through the first flow channel connected to the mixing chamber when the syringe injects the drug into the first channel, and can make the drug be directly delivered to the microfluidic chip through the first flow channel connected to the first hose.

[0010] Further, the mixing tank is provided with a second channel connected with the second injector outlet, one end of the second channel is divided into two second flow channels, one of which extends to the mixing chamber, and the other is connected to the second hose; wherein the first flow channel and the second flow channel are provided with check valves at the connection with the mixing chamber.

[0011] The two second flow channels are arranged to allow the drug solution to flow into the mixing chamber and mix with the first flow channel when the injector injects the drug solution into the second channel.

[0012] Further, the first flow channel and the second flow channel are provided with a driven impeller, the driven impeller is fixedly connected with an extension shaft extending into the mixing chamber, and the extension shaft is fixedly connected with the stirring impeller in the mixing chamber.

[0013] The driven impeller is arranged to rotate the extension shaft when the drug solution in the first flow channel or the second flow channel is transported to the mixing chamber, and then the stirring impeller is rotated to stir the drug solution in the mixing chamber to fully mix it.

[0014] Further, the mounting frame includes two fixed plates fixedly arranged in the housing and arranged vertically, the upper fixed plate is fixedly connected with a motor, the power output end of the motor is fixedly connected with a lead screw, a sliding plate is arranged between the two fixed plates and slides vertically, the lead screw passes through the sliding plate and is threadedly connected with the sliding plate, and a guide column is fixedly connected between the two fixed plates and slidably connected with the sliding plate.

[0015] The sliding plate is arranged to slide and push the piston rod of the injector to extrude the drug solution in the injector from the infusion end.

[0016] Further, the lower fixed plate is provided with a support bracket for placing the injector, and the injector is vertically placed on the support bracket.

[0017] The support bracket is arranged to vertically place the injector on the support bracket, which facilitates the extrusion of the injector by the sliding plate.

[0018] Further, the sliding plate is provided with a cylindrical portion arranged around the injector, a slot extending vertically is formed in the cylindrical portion, a push plate slides in the slot in a direction perpendicular to the axis of the cylindrical portion, a plurality of extension heads extend in a direction perpendicular to the axis of the cylindrical portion and are fixedly connected to the push plate, and the extension heads are used to abut one end of the piston rod of the injector.

[0019] Through the setting of the cylindrical part and the telescopic head, when the sliding plate moves, the cylindrical part can be driven to move, and then the telescopic head moves up and down, through the setting of the push plate, when the push plate moves to the center of the cylindrical part, the telescopic head abuts on the piston rod of the syringe, and the telescopic head shrinks, when the telescopic head is located on the upper side of the piston rod of the syringe, the telescopic head can contact the upper end of the piston rod, when the cylindrical part moves downward to drive the telescopic head to move downward, the piston rod is pushed to extrude the liquid medicine in the syringe.

[0020] Further, the telescopic head comprises a sleeve part fixedly arranged on the push plate and an extending part slidingly arranged in the sleeve part, a compression spring is connected between the extending part and the sleeve part, and two ends of the compression spring are fixedly connected to the sleeve part and the extending part respectively, a bidirectional air cylinder is fixedly connected to the lower fixed plate, and an installation plate slidingly matched with the push plate is fixedly connected to one end of a piston rod of the bidirectional air cylinder.

[0021] Through the setting of the sleeve part and the telescopic part, when the telescopic head moves to the syringe, the telescopic part abutting on the side of the piston rod of the syringe shrinks, and the telescopic head located on the upper end of the piston rod can abut on the upper end face of the piston rod, and when the sleeve part moves downward, the piston rod can be pushed.

[0022] Further, the mixing tank is provided with a control assembly for controlling the delivery of liquid medicine to the micro-fluidic chip, the control assembly comprises: a rack fixedly arranged at the lower end of the push plate; two rotating shafts rotatably arranged on the mixing tank, one end of each of the two rotating shafts is fixedly connected with a first gear meshing with the two racks, and one end of each of the two rotating shafts is inserted into the mixing tank and located on one side of the first channel and the second channel respectively; and a closing plate fixedly arranged on the rotating shafts for closing the first channel and the second channel.

[0023] Through the setting of the rack and the closing plate, when the push plate moves to the syringe, the closing plate can be driven to rotate by the rack, and then the first channel or the second channel is no longer closed, and the liquid medicine can be injected. When the push plate does not move to the syringe, the closing plate closes the first channel or the second channel, so that the liquid medicine in the syringe cannot flow into the first channel or the second channel.

[0024] The beneficial effects of the present application are:

[0025] 1. Through the setting of the first syringe and the second syringe, different medicines can be delivered to the micro-fluidic chip, and through the setting of the mixing assembly, the medicines can be delivered to the micro-fluidic chip respectively or mixed and then delivered to the micro-fluidic chip, which is more flexible, and through the setting of the mixing chamber and the stirring impeller, the liquid medicine is fully mixed in the mixing chamber, and through the setting of the first hose, the second hose and the third hose, the liquid medicine is output respectively.

[0026] 2、Through the driven impeller and the stirring impeller, when the liquid medicine in the first flow channel or the second flow channel is transported to the mixing cavity, the extension shaft is driven to rotate, and then the stirring impeller is driven to rotate to stir the liquid medicine in the mixing cavity, so that the liquid medicine is fully mixed.

[0027] 3、Through the electromagnetic valve, the communication of the first hose, the second hose and the third hose can be controlled. When the single liquid medicine needs to be transported to the micro-fluidic chip, the electromagnetic valve controls the third hose to be closed, so that the liquid medicine cannot enter the mixing cavity. When the mixed liquid medicine needs to be transported to the micro-fluidic chip, the electromagnetic valve controls the first hose and the second hose to be closed, so that the first liquid medicine and the second liquid medicine flow into the mixing cavity to be mixed. BRIEF DESCRIPTION OF DRAWINGS

[0028] The accompanying drawings, which form a part of this application, are included to provide a further understanding of the application and are incorporated in and constitute a part of this application. The drawings illustrate embodiments of the present application and, together with the description, serve to explain the application. It should be understood that the drawings are schematic and the elements and features are not necessarily drawn to scale.

[0029] In addition, throughout the drawings, same or similar reference numerals are used to represent same or similar elements. It should be understood that the drawings are schematic, and the elements and elements are not necessarily drawn to scale.

[0030] In the drawings:

[0031] Figure 1 is a schematic diagram of the whole according to an embodiment of the application;

[0032] Figure 2 is Figure 1 is a schematic diagram of the mounting of the mounting bracket in the embodiment;

[0033] Figure 3 is Figure 1 is a schematic diagram of the mounting of the fixed plate and the sliding plate in the embodiment;

[0034] Figure 4 is Figure 1 is a schematic diagram of the structure of the cylindrical part in the embodiment;

[0035] Figure 5 is Figure 1 is a schematic diagram of the structure of the telescopic head in the embodiment;

[0036] Figure 6 is Figure 1 is a sectional view of the mixing cavity in the embodiment;

[0037] Figure 7 is Figure 1 is a sectional view of the first flow channel and the second flow channel in the embodiment.

[0038] Reference signs:

[0039] 100, housing; 101, fixed plate; 102, mounting frame; 103, microfluidic chip; 104, first hose; 105, second hose; 106, third hose; 107, mixing tank; 108, mixing cavity; 109, stirring impeller; 110, door plate; 111, fixed plate; 112, sliding plate; 113, motor; 114, screw rod; 115, support bracket; 116, first syringe; 117, second syringe; 118, cylindrical portion; 119, notch; 120, push plate; 121, telescopic head; 122, sleeve portion; 123, extending portion; 124, compression spring; 125, two-way cylinder; 126, first channel; 127, second channel; 128, first flow channel; 129, second flow channel; 130, check valve; 131, driven impeller; 132, electromagnetic valve; 133, rack; 134, rotating shaft; 135, first gear; 136, closing plate. DETAILED DESCRIPTION

[0040] Embodiments of the present disclosure will be described in more detail with reference to the drawings. Although certain embodiments of the present disclosure are shown in the drawings, it is understood that the present disclosure can be embodied in various forms and should not be interpreted as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that the present disclosure can be more thoroughly and completely understood. It should be understood that the drawings of the present disclosure are only for illustrative purposes and are not intended to limit the scope of protection of the present disclosure.

[0041] In addition, it should be further noted that only the parts related to the present application are shown in the drawings for ease of description. The embodiments in the present disclosure and the features in the embodiments can be combined with each other without conflict.

[0042] It should be noted that the terms "first", "second", etc. mentioned in the present disclosure are only used to distinguish different devices, modules or units, and are not intended to limit the order or interdependence of the functions performed by these devices, modules or units.

[0043] It should be noted that the adjectives "one" and "multiple" mentioned in the present disclosure are illustrative and not limiting, and those skilled in the art should understand that, unless otherwise explicitly stated in the context, it should be understood as "one or more".

[0044] The present disclosure will be described in detail below with reference to the drawings and in conjunction with embodiments.

[0045] Reference Figures 1-7The tumor drug delivery experimental device based on microfluidics comprises a shell 100, a syringe, a mounting frame 102, a microfluidic chip 103, a first hose 104, a second hose 105, a third hose 106, a mixing tank 107, a mixing cavity 108 and an impeller 109. The shell 100 is provided with a hinged and openable door plate 110, and the mounting frame 102 is fixedly arranged in the shell 100. The mounting frame 102 comprises two fixed plates 111 arranged vertically in the shell 100, and a sliding plate 112 arranged vertically between the two fixed plates 111. The upper fixed plate 111 is fixedly connected with a motor 113, and the power output end of the motor 113 is fixedly connected with a lead screw 114. The lead screw 114 penetrates through the sliding plate 112 and is threadedly connected with the sliding plate 112. The motor 113 outputs power to drive the lead screw 114 to rotate, thereby driving the sliding plate 112 to move vertically. The two fixed plates 111 are fixedly connected with a guide column penetrating through the sliding plate 112 and slidably connected with the sliding plate 112, and the guide column provides guidance for the sliding plate 112.

[0046] The lower fixed plate 111 is fixedly provided with two support supports 115 for placing the syringes. The syringes are vertically inserted into the support supports 115, and the support supports 115 limit the syringes. The syringes can be removed from the support supports 115, which facilitates the suction and discharge of the drug liquid. The syringe comprises a piston part and a liquid outlet end provided at the lower end of the piston part, and the piston part has a piston rod for pushing. The two support supports 115 are respectively provided with a first syringe 116 and a second syringe 117. The first syringe 116 contains a first drug liquid, and the second syringe 117 contains a second drug liquid. The sliding plate 112 is provided with a cylindrical portion 118 which is sleeved on the outer edge of the piston rod of the syringe. The cylindrical portion 118 is provided with a slot 119 extending vertically, and the slot 119 is slidably provided with a push plate 120 vertically to the axis of the cylindrical portion 118. The push plate 120 is fixedly connected with a plurality of extension heads 121 extending vertically to the axis of the cylindrical portion 118. When the extension heads 121 are located at the upper end of the piston rod, the piston rod of the syringe can be pressed downward.

[0047] The telescopic head 121 includes a sleeve part 122 fixedly arranged on the push plate 120 and an extending part 123 slidably arranged in the sleeve part 122, and a compression spring 124 is connected between the extending part 123 and the sleeve part 122, and the two ends of the compression spring 124 are fixedly connected to the sleeve part 122 and the extending part 123 respectively. When the push plate 120 moves towards the syringe, the telescopic head 121 will abut against the piston rod of the syringe, and when abutting against the side surface of the piston rod, the extending part 123 will be retracted; when the telescopic head 121 is located at the upper end of the piston rod of the syringe, the projection of the extending part 123 in the vertical direction will coincide with the piston rod of the syringe, and at this time, the upper end surface of the piston rod can be contacted. When the telescopic head 121 moves downward, the piston rod can be pushed to move downward. The lower fixed plate 111 is fixedly connected with a double-acting cylinder 125, and the piston rod of the double-acting cylinder 125 is fixedly connected with a mounting plate 101 which is in sliding fit with the push plate 120.

[0048] The lower end of the push plate 120 is fixedly connected with a rack 133, and two rotating shafts 134 are rotatably arranged on the mixing tank 107, and one end of each of the two rotating shafts 134 is fixedly connected with a first gear 135 which is in meshing engagement with the two racks 133. One end of each of the two rotating shafts 134 is inserted into the mixing tank 107 and located at one side of the first channel 126 and the second channel 127 respectively, and a closing plate 136 is fixedly arranged on the rotating shaft 134, and the closing plate 136 can block the first channel 126 and the second channel 127, wherein the mixing tank 107 has a groove for accommodating the closing plate 136, so that the closing plate 136 can be rotated, and when the closing plate 136 is rotated to the position of the first channel 126 or the second channel 127, the closing plate 136 can block the first channel 126 or the second channel 127, so that the air and the liquid medicine can no longer flow.

[0049] The mixing tank 107 is fixedly arranged in the housing 100 and located at the lower side of the mounting frame 102. The mixing tank 107 is provided with a first channel 126 and a second channel 127. The infusion end of the first syringe 116 and the second syringe 117 is respectively connected with a pipeline and the first channel 126 and the second channel 127. The piston rod end of the press syringe is provided, so that the first liquid medicine in the first syringe 116 enters the first channel 126. The second liquid medicine in the second syringe 117 enters the second channel 127.

[0050] The microfluidic chip 103 is fixedly arranged in the housing 100, and the mixing tank 107 is connected with a first hose 104 for conveying the first liquid medicine, a second hose 105 for conveying the second liquid medicine to the microfluidic chip 103, and a third hose 106 for conveying the mixed liquid medicine of the first liquid medicine and the second liquid medicine to the microfluidic chip 103.

[0051] The first channel 126 is divided into two first flow channels 128 at one end, and the liquid medicine in the first channel 126 flows into the two flow channels. The mixing cavity 108 is arranged in the mixing tank 107, one of the two first flow channels 128 extends to the mixing cavity 108, so that the first liquid medicine can flow into the mixing cavity 108. The other flow channel is connected with the first hose 104 to directly deliver the first liquid medicine to the microfluidic chip 103.

[0052] The second channel 127 is also divided into two second flow channels 129 at one end, and the second liquid medicine enters the second channel 127 by pressing the piston rod of the second syringe 117. One of the two second flow channels 129 extends to the mixing cavity 108, so that the second liquid medicine can flow into the mixing cavity 108 to mix with the first liquid medicine, and the other second flow channel 129 is connected with the second hose 105, and the second liquid medicine is delivered to the microfluidic chip 103 through the second hose 105. The connection between the first flow channel 128 and the second flow channel 129 and the mixing cavity 108 is provided with a check valve 130.

[0053] The first flow channel 128 and the second flow channel 129 connected with the mixing cavity 108 are rotatably connected with a driven impeller 131. The rotation of the driven impeller 131 is driven by the flow of the liquid medicine in the first flow channel 128 and the second flow channel 129. The driven impeller 131 is coaxially fixedly connected with an extension shaft, and the extension shaft is fixedly connected with the stirring impeller 109 in the mixing cavity 108.

[0054] The first hose 104, the second hose 105 and the third hose 106 are all provided with electromagnetic valves 132, and the connection and disconnection with the microfluidic chip 103 are controlled through the electromagnetic valves 132. The third hose 106 is in communication with the mixing cavity 108.

[0055] Use method or working steps:

[0056] 1. When the first liquid medicine needs to be delivered to the microfluidic chip 103, the electromagnetic valves 132 of the second hose 105 and the third hose 106 are closed, the corresponding piston rod of the double-action pneumatic cylinder 125 is controlled to be elongated, the push plate 120 is driven to move, the telescopic head 121 is located at the upper side of the piston rod of the first syringe 116, the piston rod of the first syringe 116 is pushed, the motor 113 is started to drive the sliding plate 112 to move, and then the push plate 120 is driven to move, so that the telescopic head 121 pushes the piston rod of the first syringe 116. The first liquid medicine is pushed into the first channel 126, and since the third hose 106 is disconnected with the microfluidic chip 103 at this time, the first liquid medicine flows into the first flow channel 128 connected with the first hose 104 under the action of pressure. Then the first liquid medicine is delivered to the microfluidic chip 103 through the first hose 104.

[0057] 2、When the second liquid medicine needs to be delivered to the microfluidic chip 103, the electromagnetic valve 132 of the first hose 104 and the third hose 106 is closed, the corresponding piston rod of the double-acting cylinder 125 is controlled to extend, the push plate 120 is driven to move, the telescopic head 121 is located at the upper side of the piston rod of the second syringe 117, and the telescopic head 121 pushes the piston rod of the second syringe 117. The second liquid medicine is pushed into the second channel 127, and the second liquid medicine is delivered to the microfluidic chip 103 through the second flow channel 129 and the second hose 105 under the action of pressure.

[0058] 3、When the first liquid medicine and the second liquid medicine need to be mixed and delivered to the microfluidic chip 103, the electromagnetic valve 132 of the first hose 104 and the second hose 105 is closed, the two piston rods of the double-acting cylinder 125 are controlled to extend, so that the telescopic head 121 is located at the upper side of the piston rod of the first syringe 116 and the upper side of the piston rod of the second syringe 117. By starting the motor 113, the telescopic head 121 synchronously presses the piston rod of the first syringe 116 and the piston rod of the second syringe 117. Since the electromagnetic valve 132 disconnects the first hose 104, the second hose 105 and the microfluidic chip 103 at this time, the first liquid medicine and the second liquid medicine flow into the mixing chamber 108 under the action of pressure, and the driven impeller 131 is driven to rotate while the first liquid medicine and the second liquid medicine flow, and then the stirring impeller 109 is driven to rotate, thereby stirring and mixing the liquid medicine in the mixing chamber 108. At the same time, the mixed liquid medicine is delivered to the microfluidic chip 103 through the third hose 106 under the action of pressure.

[0059] 4、When the mixed liquid medicine in the mixing chamber 108 needs to be completely discharged, the first syringe 116 and the second syringe 117 are removed from the support bracket 115, and after the liquid medicine is discharged, they are installed on the support bracket 115, so that the first syringe 116 and the second syringe 117 are filled with gas, the first electromagnetic valve 132 and the second electromagnetic valve 132 are closed, and the gas enters the mixing chamber 108. Under the action of air pressure, the mixed liquid medicine is completely discharged.

[0060] The above description is only some of the preferred embodiments of the present disclosure and a description of the technical principles applied. Those skilled in the art should understand that the scope of the application involved in the embodiments of the present disclosure is not limited to the technical solutions formed by the specific combinations of the above technical features, and should also cover other technical solutions formed by any combination of the above technical features or equivalent features without departing from the above inventive concept. For example, the above features are replaced with each other to form a technical solution with similar functions disclosed in the embodiments of the present disclosure (but not limited to).

Claims

1. A microfluidic-based tumor drug delivery experimental device, characterized by: The device comprises: a shell (100) hinged on one side with a door panel (110); two syringes arranged in the shell (100), including a first syringe (116) and a second syringe (117), the first syringe (116) and the second syringe (117) are respectively provided with a first drug and a second drug; a mounting rack (102) for mounting the syringes; a microfluidic chip (103) fixedly arranged in the shell (100), the drug is introduced into the microfluidic chip (103) through the syringes; a mixing assembly arranged in the shell (100), the drug is introduced into the microfluidic chip (103) through the mixing assembly, the mixing assembly is provided with a first hose (104) for delivering the first drug to the microfluidic chip (103), a second hose (105) for delivering the second drug to the microfluidic chip (103), and a third hose (106) for delivering the mixed drug to the microfluidic chip (103), and the first hose (104), the second hose (105), and the third hose (106) are all provided with electromagnetic valves (132); the mixing assembly comprises: a mixing tank (107) arranged in the shell (100) and located below the mounting rack (102), the liquid outlet ends of the first syringe (116) and the second syringe (117) are connected to the mixing tank (107) through pipelines; a mixing chamber (108) arranged in the mixing tank (107) and used for mixing the drug, the mixing chamber (108) is connected to the third hose (106); a stirring impeller (109) rotatably arranged in the mixing chamber (108) and used for mixing the drug; wherein the syringe comprises a piston part and a liquid outlet end arranged at the lower end of the piston part, the piston part has a piston rod for pushing.

2. The microfluidic-based tumor drug delivery experimental device according to claim 1, wherein: the mixing tank (107) is provided with a first channel (126) connected to the liquid outlet end of the first syringe (116), one end of the first channel (126) is divided into two first flow channels (128), one of the first flow channels (128) extends to the mixing chamber (108), and the other first flow channel (128) is connected to the first hose (104).

3. The microfluidic-based tumor drug delivery experimental device according to claim 2, wherein: the mixing tank (107) is provided with a second channel (127) connected to the liquid outlet end of the second syringe (117), one end of the second channel (127) is divided into two second flow channels (129), one of the second flow channels (129) extends to the mixing chamber (108), and the other second flow channel (129) is connected to the second hose (105); wherein the first flow channel (128) and the second flow channel (129) are both provided with check valves (130) at the connection positions with the mixing chamber (108).

4. The microfluidic-based tumor drug delivery experimental device according to claim 3, wherein: The first flow channel (128) and the second flow channel (129) are provided with driven impellers (131) rotating therein, the driven impellers (131) are fixedly connected with extension shafts extending into the mixing cavity (108), and the extension shafts are fixedly connected with the stirring impeller (109) in the mixing cavity (108). 5.The microfluidic based tumor drug delivery experiment device according to claim 4, characterized in that: The mounting frame (102) comprises two fixed plates (111) fixedly arranged in the shell (100) and arranged in an up-down manner, the upper fixed plate (111) is fixedly connected with a motor (113), the power output end of the motor (113) is fixedly connected with a lead screw (114), the two fixed plates (111) are provided with a sliding plate (112) sliding up and down, the lead screw (114) penetrates through the sliding plate (112) and is threadedly connected with the sliding plate (112), and the two fixed plates (111) are fixedly connected with a guide column penetrating through the sliding plate (112) and slidingly connected with the sliding plate (112). 6.The microfluidic based tumor drug delivery experiment device according to claim 5, characterized in that: The lower fixed plate (111) is provided with a support bracket (115) for placing a syringe, and the syringe is vertically placed on the support bracket (115). 7.The microfluidic based tumor drug delivery experiment device according to claim 6, characterized in that: The sliding plate (112) is provided with a cylindrical portion (118) arranged at the outer edge of the syringe, the cylindrical portion (118) is provided with a slot (119) extending in an up-down direction, a push plate (120) sliding in a direction perpendicular to the axis of the cylindrical portion (118) is arranged in the slot (119), a plurality of telescopic heads (121) extending in a direction perpendicular to the axis of the cylindrical portion (118) are fixedly connected to the push plate (120), and the telescopic heads (121) are used for abutting to one end of the piston rod of the syringe. 8.The microfluidic based tumor drug delivery experiment device according to claim 7, characterized in that: The telescopic head (121) comprises a sleeve portion (122) fixedly arranged on the push plate (120) and a protruding portion (123) slidingly arranged in the sleeve portion (122), a compression spring (124) is connected between the sleeve portion (122) and the protruding portion (123), both ends of the compression spring (124) are fixedly connected to the sleeve portion (122) and the protruding portion (123) respectively, a two-way pneumatic cylinder (125) is fixedly connected to the lower fixed plate (111), and one end of the piston rod of the two-way pneumatic cylinder (125) is fixedly connected with a mounting plate (101) slidingly matched with the push plate (120). 9.The microfluidic based tumor drug delivery experiment device according to claim 8, characterized in that: The mixing tank (107) is provided with a control assembly for controlling the delivery of the drug solution to the microfluidic chip (103), and the control assembly comprises: A rack (133) fixedly arranged at the lower end of the push plate (120). Rotary shafts (134) are arranged in parallel on the mixing tank (107), and one end of each rotary shaft (134) is fixedly connected with a first gear (135) engaged with a gear rack (133). The rotary shafts (134) are inserted into the mixing tank (107) and located on one side of the first channel (126) and the second channel (127) respectively. A closing plate (136) is fixedly arranged on the rotary shaft (134) and used for closing the first channel (126) and the second channel (127).

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