Skin clamping device for drug transdermal tester

Abstract

The utility model relates to the technical field of skin clamping, and discloses a skin clamping device for a drug transdermal tester, which comprises a mounting seat, a plurality of mounting holes are formed in the top of the mounting seat, a plurality of positioning grooves are formed in the top of the mounting seat, springs are fixedly connected to the bottom ends of the interiors of the mounting holes, and the springs are arranged in the positioning grooves. Protective pads are fixedly connected to the tops of the multiple springs, supporting columns are slidably connected to the interiors of the multiple mounting holes, clamping blocks are fixedly connected to the bottom ends of the front sides and the rear sides of the multiple supporting columns, threaded rods are fixedly connected to the tops of the multiple supporting columns, and two chucks are slidably connected to the outer walls of the multiple threaded rods; the tops of the outer walls of the multiple threaded rods are in threaded connection with nuts. According to the skin sample clamping device, the supporting columns are installed at different positions to adapt to skin samples of different specifications, the clamping force is adjusted through the nuts, the effect that the device is convenient to detach for cleaning and maintenance is achieved, and the service life of the device is prolonged.

Description

Technical Field

[0001] This utility model relates to the field of skin clamping technology, and in particular to a skin clamping device for a transdermal drug testing instrument. Background Technology

[0002] In the field of modern pharmaceutical research, research on transdermal drug absorption is of paramount importance. Transdermal drug testing instruments are mainly used to simulate the process of drugs passing through the skin and accurately detect key parameters such as the transdermal penetration rate and cumulative permeation amount of drugs. This provides important data support for drug development, formulation optimization, and skin safety assessment. During the operation of the transdermal drug testing instrument, it is necessary to accurately fix the skin sample to ensure the accuracy and reliability of the test results, which requires a special skin clamping device.

[0003] The main function of the skin clamping device in a transdermal drug testing instrument is to stably and accurately fix the experimental skin sample, ensuring that the skin is in an ideal testing state during the transdermal drug testing process. The clamping device not only prevents the skin from shifting during the test, ensuring the consistency of drug-skin interaction, but also controls the microenvironment around the skin, simulating some characteristics of human skin in its natural state, providing a reliable experimental basis for transdermal drug testing, thereby improving the accuracy and repeatability of transdermal drug testing data.

[0004] To ensure the skin remains fixed during experiments, applying excessive pressure to the clamping device can cause mechanical damage to the skin, affecting the accuracy of the experimental results. Existing technologies incorporate a buffer structure inside the clamp. When the clamp clamps the skin, the buffer structure can absorb some of the impact force, reducing the risk of skin damage. However, the clamping device needs to be cleaned after contact with different skin samples. Existing clamping devices are relatively complex in structure to achieve multiple functions, and there are some blind spots during cleaning, which is not conducive to the daily maintenance and upkeep of the device. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a skin clamping device for a transdermal drug testing instrument, which aims to improve the problem that the existing device has a relatively complex structure and is not conducive to cleaning and maintenance.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a skin clamping device for a transdermal drug testing instrument, comprising a mounting base, wherein the top of the mounting base has multiple mounting holes and multiple positioning grooves, springs are fixedly connected to the bottom of the interior of each of the mounting holes, protective pads are fixedly connected to the top of each of the springs, support columns are slidably connected to the interior of each of the mounting holes, locking blocks are fixedly connected to the front and rear bottom ends of each of the support columns, threaded rods are fixedly connected to the top of each of the support columns, two clamps are slidably connected to the outer wall of each of the threaded rods, and nuts are threadedly connected to the top of the outer wall of each of the threaded rods. A humidification mechanism is provided on the right side of the mounting base, the humidification mechanism being used to regulate the humidity of the environment in which the skin is located.

[0007] As a further description of the above technical solution:

[0008] The humidification mechanism includes a water tank. The left side of the water tank is fixedly connected to the right side of the mounting base. A protective shell is fixedly connected to the top of the water tank. An air inlet is opened on the rear side of the protective shell. A fan is fixedly connected to the front side of the protective shell. Fixing strips are fixedly connected to the left and right sides of the top of the water tank. The same humidifying cotton is slidably connected to the inner wall of the two fixing strips.

[0009] As a further description of the above technical solution:

[0010] Two rubber pads are fixedly connected between adjacent clamps, and an anti-loosening washer is provided at the bottom of the nut.

[0011] As a further description of the above technical solution:

[0012] A lamp holder is fixedly connected to the top left side of the mounting base, and a lighting lamp is fixedly connected to the top of the lamp holder.

[0013] As a further description of the above technical solution:

[0014] The mounting base has support legs fixedly connected to the four corners at its bottom, and suction cups are fixedly connected to the bottom of each of the support legs.

[0015] As a further description of the above technical solution:

[0016] An adjusting rod is fixedly connected to the top right side of the mounting base, and a camera is rotatably connected to the top of the adjusting rod.

[0017] As a further description of the above technical solution:

[0018] A fixing block is fixedly connected to the top front side of the mounting base, and a temperature monitoring meter is fixedly connected to the top of the fixing block.

[0019] As a further description of the above technical solution:

[0020] Multiple ventilation blades are fixedly connected to each other on the left and right sides inside the air inlet, and all of the ventilation blades are designed to be equidistant.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this utility model, the support column is installed through the mounting hole, then the spring is compressed to obtain elastic support, and then the support column is rotated to make the locking block lock into the positioning groove for fixation. The support column can be installed in different mounting holes as needed. Finally, the clamping force is adjusted by the nut to achieve stable clamping of skin samples of different specifications and thicknesses, meeting diverse testing needs. It can also be easily disassembled for cleaning, which greatly facilitates the maintenance of the device and extends the service life of the device.

[0023] 2. In this utility model, water is stored in a water tank, external air is introduced through an air inlet, a fan is started to accelerate air flow, which drives the diffusion of humid air, a fixing strip stabilizes the position of the humidifying cotton, and the humidifying cotton absorbs water from the water tank and evaporates when the air flows, thus achieving the effect of precisely regulating the humidity of the skin environment, creating a suitable humidity environment for the skin, ensuring that the skin is in ideal humidity conditions during transdermal drug testing, and improving the accuracy and reliability of the test results. Attached Figure Description

[0024] Figure 1 This is a front view of a skin clamping device for a transdermal drug testing instrument proposed in this utility model;

[0025] Figure 2 This is a perspective view of a skin clamping device for a transdermal drug testing instrument proposed in this utility model;

[0026] Figure 3 This is a right view of a skin clamping device for a transdermal drug testing instrument proposed in this utility model;

[0027] Figure 4 This is a cross-sectional view of a skin clamping device for a transdermal drug testing instrument proposed in this utility model;

[0028] Figure 5 This is an exploded view of the humidifying cotton of the skin clamping device for a transdermal drug testing instrument proposed in this utility model.

[0029] Legend:

[0030] 1. Mounting base; 2. Humidification mechanism; 201. Water tank; 202. Protective shell; 203. Air inlet; 204. Fan; 205. Fixing strip; 206. Humidifying cotton; 3. Mounting hole; 4. Positioning groove; 5. Spring; 6. Protective pad; 7. Support column; 8. Locking block; 9. Threaded rod; 10. Clamp; 11. Nut; 12. Rubber pad; 13. Anti-detachment washer; 14. Lamp holder; 15. Lighting lamp; 16. Support leg; 17. Suction cup; 18. Adjusting rod; 19. Camera; 20. Fixing block; 21. Temperature monitor; 22. Ventilation blades. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] Reference Figure 1 and Figure 4 This utility model provides an embodiment of a skin clamping device for a transdermal drug testing instrument, comprising a mounting base 1 for supporting and fixing the entire device. The top of the mounting base 1 has multiple mounting holes 3 for mounting support columns 7. The top of the mounting base 1 also has multiple positioning grooves 4 for fixing the support columns 7, preventing them from being easily pulled out. Springs 5 ​​are fixedly connected to the bottom of each of the mounting holes 3, providing elastic support. Protective pads 6 are fixedly connected to the top of each of the springs 5, preventing direct contact between the springs 5 ​​and the support columns 7 and causing damage. The interiors of the mounting holes 3 are slidably connected... There are support columns 7, which support threaded rods 9. The bottom ends of the front and rear sides of multiple support columns 7 are fixedly connected with locking blocks 8, which prevent the support columns 7 from coming out of the mounting holes 3. The top of multiple support columns 7 is fixedly connected with threaded rods 9, which are used to install clamps 10 and cooperate with nuts 11 to clamp the skin. The outer walls of multiple threaded rods 9 are slidably connected with two clamps 10, which are used to clamp skin samples. The top of the outer walls of multiple threaded rods 9 is threadedly connected with nuts 11, which can adjust the clamping force of clamps 10 by tightening nuts 11. A humidification mechanism 2 is provided on the right side of the mounting base 1, which is used to regulate the humidity of the environment where the skin is located.

[0033] Specifically, the mounting base 1 is used to support and fix the entire device, providing stable placement. The mounting hole 3 is used to install the support column 7, enabling the support column 7 to be positioned. Inserting the support column 7 into the mounting hole 3 and compressing the spring 5 provides elastic support, thus providing elastic support for the support column 7. The protective pad 6 prevents the spring 5 from directly contacting the support column 7 and causing damage, providing protection. Rotating the support column 7 engages the locking block 8 into the positioning groove 4 to complete the fixation. The positioning groove 4 secures the support column 7, preventing it from being easily pulled out and ensuring the proper installation of the support column 7. The stability is excellent, and when cleaning is required, the support column 7 can be easily rotated to remove it, facilitating cleaning of the clamping device and providing easy cleaning and maintenance. The threaded rod 9 is used to install the chuck 10 and work with the nut 11 to clamp the skin, completing the clamping operation of the skin sample. The nut 11 can be tightened to adjust the clamping force of the chuck 10 to adapt to skin samples of different thicknesses, achieving adaptive clamping of skin samples of different thicknesses. By installing the support column 7 in the mounting holes 3 at different positions, it can clamp skin samples of different specifications, meeting the testing needs of skin samples of different specifications.

[0034] Reference Figure 2 and Figure 5 The humidifying mechanism 2 includes a water tank 201, which stores the water required for humidification. The left side of the water tank 201 is fixedly connected to the right side of the mounting base 1, achieving a stable connection between the humidifying mechanism 2 and the mounting base 1. A protective shell 202 is fixedly connected to the top of the water tank 201, which protects the internal fan 204. An air inlet 203 is provided on the rear side of the protective shell 202, which introduces external air to provide an air source for the humidification process. A fan 204 is fixedly connected to the front. When the fan 204 is turned on, it can accelerate the air flow and make the humid air better diffuse to the skin environment. Fixing strips 205 are fixedly connected to the top left and right sides of the water tank 201. The fixing strips 205 are used to fix the position of the humidifying cotton 206. The same humidifying cotton 206 is slidably connected to the inner wall of the two fixing strips 205. The humidifying cotton 206 can absorb the water in the water tank 201 and evaporate the water when the air flows, thereby regulating the humidity of the skin environment.

[0035] Specifically, the water tank 201 stores the water required for humidification, providing a sufficient water source for the subsequent humidification process. The protective shell 202 protects the internal fan 204, effectively preventing damage to components from external factors and ensuring stable operation of the fan 204. The air inlet 203 introduces external air, providing an air source for the humidification process and ensuring a continuous air supply so that the humidification process can proceed smoothly. After the fan 204 is turned on, it can accelerate airflow, allowing humidified air to better diffuse to the skin environment, enhancing the humidification effect and making the ambient humidity more uniform. The fixing strip 205 is used to fix the position of the humidifying cotton 206, ensuring that the humidifying cotton 206 works stably and preventing it from shifting and affecting the humidification function. The humidifying cotton 206 can absorb the water in the water tank 201 and evaporate the water when the air flows, thereby regulating the humidity of the skin environment and achieving effective humidity regulation, creating a suitable humidity environment for the skin.

[0036] Reference Figure 1 and Figure 4 Two rubber pads 12 are fixedly connected between adjacent clamps 10. The rubber pads 12 can increase the friction between the clamps 10 and the skin, and at the same time protect the skin sample and prevent damage to the skin sample. The bottom of the nut 11 is provided with an anti-loosening washer 13. The anti-loosening washer 13 can effectively prevent the nut 11 from loosening and falling off during use, and ensure the stable clamping state of the clamps 10. The top left side of the mounting base 1 is fixedly connected with a lamp holder 14. The lamp holder 14 is used to support and fix the lighting lamp 15. The top of the lamp holder 14 is fixedly connected with the lighting lamp 15. The lighting lamp 15 can provide illumination, making it easy for the operator to clearly observe the clamping status of the skin and the testing process. The four corners of the bottom of the mounting base 1 are all fixedly connected with support legs 16. The support legs 16 can support the mounting base 1, so that the device can be stably placed on the worktable. The bottom of the multiple support legs 16 is fixedly connected with suction cups 17. The suction cups 17 can enhance the adsorption force between the device and the worktable and prevent the device from shifting during the test.

[0037] Specifically, the rubber pad 12 increases the friction between the clamp 10 and the skin, while also protecting the skin sample and preventing damage. This ensures a stable and safe gripping of the skin sample. The anti-detachment pad 13 effectively prevents the nut 11 from loosening and falling off during use, ensuring the stability of the clamping state of the clamp 10 and maintaining the normal operation of the device. The lamp holder 14 supports and fixes the lighting lamp 15, providing a stable mounting base for the lighting lamp 15 and ensuring its proper position. The lighting lamp 15 provides illumination, allowing operators to clearly observe the skin clamping situation and the testing process, improving the accuracy and efficiency of the operation. The support leg 16 supports the mounting base 1, enabling the device to be stably placed on the worktable and providing a stable support structure for the entire device. The suction cup 17 enhances the adhesion between the device and the worktable, preventing displacement of the device during testing and further ensuring the stability and reliability of the testing process.

[0038] Reference Figure 2 , Figure 3 and Figure 5 An adjustment rod 18 is fixedly connected to the top right side of the mounting base 1. The adjustment rod 18 is used to adjust the position and angle of the camera 19 to meet different shooting needs. The camera 19 is rotatably connected to the top of the adjustment rod 18. The camera 19 can shoot and record the skin clamping part and the testing process for easy subsequent analysis and research. A fixing block 20 is fixedly connected to the top front side of the mounting base 1. The fixing block 20 is used to support and fix the temperature monitoring meter 21. The temperature monitoring meter 21 is fixedly connected to the top of the fixing block 20. The temperature monitoring meter 21 can monitor the temperature of the skin environment in real time to ensure that the test is carried out under suitable temperature conditions. Multiple ventilation blades 22 are fixedly connected between adjacent left and right sides inside the air inlet 203. The ventilation blades 22 can guide the airflow into the air inlet 203 and optimize the airflow path. The multiple ventilation blades 22 are all designed with equal spacing to ensure that the airflow into the air inlet 203 is uniform and the humidification effect is more stable.

[0039] Specifically, the adjusting rod 18 is used to adjust the position and angle of the camera 19 to meet different shooting needs and flexibly realize diverse shooting functions. The camera 19 is installed on the top of the adjusting rod 18 and can record the skin clamping area and the testing process, which is convenient for subsequent analysis and research, and provides intuitive image data for data preservation and research. The fixing block 20 is used to support and fix the temperature monitoring meter 21, which can stably place the temperature monitoring meter 21 and ensure its normal operation. The temperature monitoring meter 21 can monitor the temperature of the environment where the skin sample is located in real time, ensuring that the test is carried out under suitable temperature conditions, ensuring the temperature suitability of the test environment, and improving the accuracy of the test. The ventilation blades 22 can guide the airflow into the air inlet 203 and optimize the airflow path. Multiple ventilation blades 22 are all designed with equal spacing to ensure that the airflow into the air inlet 203 is uniform, making the humidification effect more stable and effectively improving the ventilation and humidification effect.

[0040] Working principle: When the skin clamping device of the transdermal drug testing instrument is working, firstly, the support column 7 is inserted into the mounting hole 3. During the process, the spring 5 is compressed, and the spring 5 provides elastic support, which provides elastic support for the support column 7. The protective pad 6 prevents the spring 5 from directly contacting the support column 7 and causing damage. Next, the support column 7 is rotated so that the locking block 8 is locked into the positioning groove 4 to complete the fixation. The positioning groove 4 ensures the stability of the support column 7 installation and prevents it from being easily pulled out. By installing the support column 7 in the mounting hole 3 at different positions, the testing clamping requirements of skin samples of different specifications can be met. Finally, the clamping force of the clamp 10 can be adjusted by tightening the nut 11 to adapt to skin samples of different thicknesses. When the device needs to be cleaned, the support column 7 can be easily disassembled by rotating it, making the cleaning and maintenance of the clamping device more convenient.

[0041] Furthermore, when the humidifier is working, the water tank 201 plays its role first, storing the water required for humidification and providing a sufficient water source for the subsequent humidification process. Then, the air inlet 203 starts working, introducing external air to provide an air source for the humidification process and ensure a continuous supply of air. The fan 204 starts, accelerating airflow and allowing humidified air to better diffuse to the skin environment, enhancing the humidification effect and making the ambient humidity more uniform. During this period, the fixing strip 205 fixes the position of the humidifying cotton 206, ensuring that the humidifying cotton 206 works stably and preventing it from shifting and affecting the humidification function. Finally, the humidifying cotton 206 absorbs the water in the water tank 201 and evaporates the water when the air flows, thereby regulating the humidity of the skin environment and achieving effective humidity regulation to create a suitable humidity environment for the skin.

[0042] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A skin clamping device for a transdermal drug testing instrument, comprising a mounting base (1), characterized in that: The mounting base (1) has multiple mounting holes (3) on its top and multiple positioning grooves (4) on its top. Springs (5) are fixedly connected to the bottom of the multiple mounting holes (3). Protective pads (6) are fixedly connected to the top of the multiple springs (5). Support columns (7) are slidably connected to the inside of the multiple mounting holes (3). Locking blocks (8) are fixedly connected to the bottom of the front and rear sides of the multiple support columns (7). Threaded rods (9) are fixedly connected to the top of the multiple support columns (7). Two clamps (10) are slidably connected to the outer wall of the multiple threaded rods (9). Nuts (11) are threadedly connected to the top of the outer wall of the multiple threaded rods (9). A humidifying mechanism (2) is provided on the right side of the mounting base (1). The humidifying mechanism (2) is used to regulate the humidity of the environment where the skin is located.

2. The skin clamping device for a drug transdermal testing instrument according to claim 1, characterized in that: The humidification mechanism (2) includes a water tank (201). The left side of the water tank (201) is fixedly connected to the right side of the mounting base (1). A protective shell (202) is fixedly connected to the top of the water tank (201). An air inlet (203) is opened on the rear side of the protective shell (202). A fan (204) is fixedly connected to the front side of the protective shell (202). Fixing strips (205) are fixedly connected to the left and right sides of the top of the water tank (201). The inner walls of the two fixing strips (205) are slidably connected to the same humidifying cotton (206).

3. The skin clamping device for a drug transdermal testing instrument according to claim 1, characterized in that: Two rubber pads (12) are fixedly connected between adjacent clamps (10), and an anti-loosening washer (13) is provided at the bottom of the nut (11).

4. The skin clamping device for a drug transdermal testing instrument according to claim 1, characterized in that: A lamp holder (14) is fixedly connected to the top left side of the mounting base (1), and a lighting lamp (15) is fixedly connected to the top of the lamp holder (14).

5. The skin clamping device for a drug transdermal testing instrument according to claim 1, characterized in that: The mounting base (1) has four fixed support legs (16) at the bottom corners, and the bottom of each of the support legs (16) has a suction cup (17) fixedly connected.

6. The skin clamping device for a drug transdermal testing instrument according to claim 1, characterized in that: An adjusting rod (18) is fixedly connected to the top right side of the mounting base (1), and a camera (19) is rotatably connected to the top of the adjusting rod (18).

7. The skin clamping device for a drug transdermal testing instrument according to claim 1, characterized in that: A fixing block (20) is fixedly connected to the top front side of the mounting base (1), and a temperature monitoring meter (21) is fixedly connected to the top of the fixing block (20).

8. The skin clamping device for a drug transdermal testing instrument according to claim 2, characterized in that: Multiple ventilation blades (22) are fixedly connected between adjacent sides inside the air inlet (203), and all of the ventilation blades (22) are designed to be equidistant.

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