Optimized protein purification instrument

Abstract

The utility model discloses an optimized protein purification instrument, and relates to the technical field of protein purification instruments. The protein purification instrument comprises a protein purification instrument body and reagent bottles arranged on the two sides of the top of the protein purification instrument body, and further comprises heat dissipation grooves formed in the positions, close to the bottom, of the two sides in the protein purification instrument body; the isolation hood is connected to the front end of the protein purification instrument body in a covering manner, and a transparent window is arranged in the middle of the front end in the isolation hood. According to the protein purification instrument, the isolation cover is arranged at the front end of the protein purification instrument body through the connecting structure, so that modules arranged at the front end of the protein purification instrument body can be covered, isolated and protected when protein purification work is not carried out, and meanwhile, the contact surfaces of the modules and the protein purification instrument body are sealed by a rubber pad; dust is further prevented from entering the inner side of the isolation hood to cause dust on the surface of the pump, the valve, the detector and other modules to affect normal operation of the protein purifier, and the cleaning difficulty is reduced.

Description

Technical Field

[0001] This invention belongs to the field of protein purification instrument technology, and in particular relates to an optimized protein purification instrument. Background Technology

[0002] A protein purification instrument is a device used to separate and purify specific proteins from biological samples. It uses specific chromatography techniques to separate and purify the desired proteins from mixtures. Currently, protein purification instruments are widely used in many fields such as drug development and production, vaccine preparation, medical research, and personalized medicine and precision treatment.

[0003] However, during the application of protein purification instruments, the system pumps, cleaning pumps, collection valves, pH detectors and other pump and valve devices at the front end of the instrument are exposed. When the equipment is not in use, dust can easily accumulate on the connection ports of various pumps, valves and pipelines as well as the detection modules, which can easily lead to contamination of biological samples and affect the protein purification effect. There is a technical problem that it is not possible to provide comprehensive isolation and protection when the protein purification instrument is not in use for protein separation and purification processing. Utility Model Content

[0004] In view of the above-mentioned shortcomings of the existing technology, the present invention provides an optimized protein purification instrument that can effectively solve the problems of the existing technology.

[0005] To solve the above-mentioned technical problems, this utility model is achieved through the following technical solution:

[0006] This utility model is an optimized protein purification instrument, including a protein purification instrument body and reagent bottles disposed on both sides of the top of the protein purification instrument body, and further including:

[0007] The heat dissipation slots are located on both sides of the inside of the protein purification instrument, near the bottom.

[0008] An isolation cover is attached to the front end of the protein purification instrument body. A transparent window is provided at the middle position of the front end of the isolation cover. A connection structure is provided between the middle position of the top and one side of the isolation cover and the top and one side of the protein purification instrument body.

[0009] The dustproof sealing structure is located between the bottom of both sides of the rear end of the isolation cover and the outside of the heat dissipation groove.

[0010] Furthermore, the inner shape of the isolation cover matches the front shape of the protein purification instrument body, and rubber pads are provided on the top, bottom and one side of the front of the protein purification instrument body.

[0011] Furthermore, the connection structure includes a positioning bracket, a mounting plate, a limiting protrusion, a stabilizing groove, and a second external lever. The positioning bracket is located at the middle position of the top and one front end of the protein purification instrument body. The mounting plate is located at the middle position of the top and one rear end of the isolation cover. A stabilizing groove is provided at the front end of the inner side of the positioning bracket. A limiting protrusion is provided on the outer side of the mounting plate. A second external lever is provided at the front end of the outer side of the positioning bracket.

[0012] Furthermore, the positioning bracket is L-shaped, and the interior of the limiting protrusion and the stabilizing slot fit together.

[0013] Furthermore, the dustproof sealing structure includes a dustproof partition and a stabilizing strip. The dustproof partition is located on both sides of the rear end of the isolation cover near the bottom. A stabilizing strip is located at the rear end of the inner side of the dustproof partition, and a first outer lever is located at the rear end of the outer side of the dustproof partition.

[0014] Furthermore, the dustproof partition corresponds to the heat dissipation groove and is attached to the bottom of both sides of the protein purification instrument body, and the stabilizing clip is inserted into the heat dissipation groove located near the rear end of both sides of the bottom of the protein purification instrument body.

[0015] This utility model has the following beneficial effects:

[0016] This invention, by setting a connecting structure to install an isolation cover at the front end of the protein purification instrument, can protect the modules located at the front end when protein purification is not in use. Simultaneously, rubber gaskets are used to seal the contact surfaces, further preventing dust from entering the inner side of the isolation cover and causing dust accumulation on the surfaces of pumps, valves, and detectors, thus affecting the normal operation of the protein purification instrument and reducing cleaning difficulty. Furthermore, when installing the isolation cover, a dustproof partition is simultaneously installed on the outside of the heat dissipation groove, preventing dust from entering the protein purification instrument through the heat dissipation groove and causing dust accumulation that could lead to aging and damage to circuits or components. Therefore, this invention achieves the effect of providing fully enclosed protection when the protein purification instrument is not in use, thereby extending its service life. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a three-dimensional schematic diagram of the present invention;

[0019] Figure 2 This is a three-dimensional partially exploded view of the present invention;

[0020] Figure 3 This is a rear-view perspective view of the isolation cover of this utility model;

[0021] Figure 4 For the present utility model Figure 1 Enlarged structural diagram at point A in the middle.

[0022] The attached diagram lists the components represented by each number as follows:

[0023] 1. Protein purification instrument body; 2. Isolation cover; 3. Dustproof partition; 4. First external lever; 5. Reagent bottle; 6. Rubber pad; 7. Positioning bracket; 8. Mounting plate; 9. Limiting protrusion; 10. Heat dissipation groove; 11. Transparent window; 12. Stabilizing strip; 13. Stabilizing slot; 14. Second external lever. Detailed Implementation

[0024] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention.

[0025] Please see Figure 1-4 As shown, this utility model is an optimized protein purification instrument, including a protein purification instrument body 1 and reagent bottles 5 disposed on both sides of the top of the protein purification instrument body 1, and further including:

[0026] The heat dissipation tank 10 is located on both sides near the bottom inside the protein purification instrument body 1. The protein purification instrument body 1 is used to separate the supernatant containing the target protein using different separation techniques according to the characteristics of the target protein. The purified protein sample is then detected and analyzed by protein electrophoresis to confirm the purity and activity of the target protein. Finally, the purified protein sample is concentrated to remove excess buffer solution and then stored under appropriate conditions to maintain its stability and activity. When the protein purification instrument body 1 is in operation, the heat dissipation tank 10 is used to dissipate the heat generated by the internal modules during operation.

[0027] An isolation cover 2 is attached to the front end of the protein purification instrument body 1. The inner shape of the isolation cover 2 matches the shape of the front end of the protein purification instrument body 1. The isolation cover 2 isolates and protects the various modules set at the front end of the protein purification instrument body 1. Rubber pads 6 are provided at the top, bottom, and one side of the front end of the protein purification instrument body 1. The rubber pads 6 ensure a tight fit between the isolation cover 2 and the front end of the protein purification instrument body 1. A transparent window 11 is provided at the middle position of the front end inside the isolation cover 2. A connection structure is provided between the middle position of the top and one side of the isolation cover 2 and the top and one side of the protein purification instrument body 1. The connection structure includes an "L"-shaped positioning bracket 7, a mounting plate 8, a limiting protrusion 9, and a stabilizing slot. 13 and second external lever 14, positioning bracket 7 is set at the middle position of the top and one front end of the protein purification instrument body 1, mounting plate 8 is set at the middle position of the top and one rear end of the isolation cover 2, the mounting cover 2 is at the front end of the protein purification instrument body 1 and the mounting plate 8 is correspondingly engaged with the inner side of the positioning bracket 7, the front end of the inner side of the positioning bracket 7 is provided with a stabilizing slot 13, the outer side of the mounting plate 8 is provided with a limiting protrusion 9, the front end of the outer side of the positioning bracket 7 is provided with a second external lever 14, the limiting protrusion 9 and the inside of the stabilizing slot 13 fit together, when the mounting plate 8 is engaged with the inner side of the positioning bracket 7, the limiting protrusion 9 is engaged with the stabilizing slot 13, thereby stabilizing the connection between the mounting plate 8 and the positioning bracket 7;

[0028] When in use, the isolation cover 2 is attached to the outside of each module set at the front end of the protein purification instrument body 1, and the mounting plate 8 set at the middle position of the top and one side of the isolation cover 2 is inserted into the inside of the positioning bracket 7 set at the middle position of the front end of the top and one side of the protein purification instrument body 1. At the same time, the limiting protrusion 9 set on the outside of the mounting plate 8 is inserted into the stabilizing slot 13 at the front end of the inner side of the positioning bracket 7, thereby firmly connecting the isolation cover 2 to the front end of the protein purification instrument body 1. It can play a role in isolation and protection when the instrument is not in use. At the same time, the rubber pad 6 is used to seal the contact surface, thereby improving the dustproof performance. When the instrument needs to be used for protein separation and purification processing, the second external lever 14 is pushed outward to make the limiting protrusion 9 relatively disengage from the stabilizing slot 13, and the isolation cover 2 can be removed to operate the instrument.

[0029] A dustproof sealing structure is set between the bottom of the rear sides of the isolation cover 2 and the outside of the heat dissipation groove 10. The dustproof sealing structure includes a dustproof partition 3 and a stabilizing strip 12. The dustproof partition 3 is set on the rear sides of the isolation cover 2 near the bottom. The dustproof partition 3 corresponds to the heat dissipation groove 10 and is attached to the bottom of the sides of the protein purification instrument body 1. The dustproof partition 3 is used to isolate and prevent dust from entering the heat dissipation groove 10 when the instrument is not in use. The stabilizing strip 12 is set at the rear end of the inner side of the dustproof partition 3. The first external lever 4 is set at the rear end of the outer side of the dustproof partition 3. The stabilizing strip 12 is engaged in the heat dissipation groove 10 set at the bottom of the sides of the protein purification instrument body 1 near the rear end. When the dustproof partition 3 is attached to the outer side of the heat dissipation groove 10, the stabilizing strip 12 is engaged in the corresponding heat dissipation groove 10 to limit and stabilize the dustproof partition 3.

[0030] When the isolation cover 2 is attached to the front end of the protein purification instrument body 1, the dustproof partitions 3 set on both sides of the bottom of the rear end of the body 1 are snapped into the bottom of both sides of the protein purification instrument body 1 and fit against the outside of the heat dissipation groove 10. At the same time, the stabilizing strip 12 set on the inner rear end of the dustproof partition 3 is snapped into the interior of the heat dissipation groove 10 at the corresponding position, which can limit and stabilize the dustproof partition 3. When removing the isolation cover 2, the first outer lever 4 can be pushed outward to remove the stabilizing strip 12 from the heat dissipation groove 10, thus making it easy to remove the dustproof partition 3.

[0031] Working principle: When using the protein purifier, after connecting the tubing to the corresponding modules and processing the supernatant containing the target protein, the sample is pumped into the instrument. Different separation techniques are used to separate the target protein according to its characteristics. Subsequently, protein electrophoresis is used to detect and analyze the purified protein sample to confirm the purity and activity of the target protein. Finally, the purified protein sample is concentrated to remove excess buffer solution and then stored under appropriate conditions to maintain its stability and activity. The heat generated by the internal modules of the protein purifier body 1 during operation is dissipated via the heat sink 10. Protein separation and purification... After the purification process is completed, the isolation cover 2 is attached to the outside of each module at the front of the protein purification instrument body 1, and the mounting plate 8 is inserted into the inside of the positioning bracket 7. At the same time, the limiting protrusion 9 is inserted into the stabilizing slot 13, thus firmly connecting the isolation cover 2 to the front of the protein purification instrument body 1. This provides isolation and protection when the instrument is not in use. Meanwhile, the rubber pad 6 is used to seal the contact surface, thereby improving dustproof performance. At the same time, the dustproof partition 3 is attached to the outside of the heat dissipation grooves 10 on both sides of the bottom of the protein purification instrument body 1 for isolation, preventing external dust from entering the instrument through the heat dissipation grooves 10 and ensuring the safety of the protein purification instrument when it is not in use.

[0032] The above are merely preferred embodiments of the present utility model and do not limit the present utility model. Any modifications, equivalent substitutions, or improvements made to the technical solutions described in the foregoing embodiments, or to some of the technical features, shall fall within the protection scope of the present utility model.

Claims

1. An optimized protein purification instrument comprising a protein purification instrument body (1) and reagent bottles (5) arranged on both sides of the top of the protein purification instrument body (1), characterized in that, Also includes: Heat dissipation slots (10) are located on both sides of the protein purification instrument body (1) near the bottom. An isolation cover (2) is attached to the front end of the protein purification instrument body (1). A transparent window (11) is provided at the middle position of the front end of the isolation cover (2). A connection structure is provided between the middle position of the top and one side of the isolation cover (2) and the top and one side of the protein purification instrument body (1). The dustproof sealing structure is located between the bottom of both sides of the rear end of the isolation cover (2) and the outside of the heat dissipation groove (10).

2. The optimized protein purification instrument of claim 1, wherein, The inner shape of the isolation cover (2) matches the front shape of the protein purification instrument body (1), and rubber pads (6) are provided on the top, bottom and one side of the front end of the protein purification instrument body (1).

3. The optimized protein purification instrument of claim 1, wherein, The connection structure includes a positioning bracket (7), a mounting plate (8), a limiting protrusion (9), a stabilizing slot (13), and a second external lever (14). The positioning bracket (7) is located at the middle position of the top and one front end of the protein purification instrument body (1). The mounting plate (8) is located at the middle position of the top and one rear end of the isolation cover (2). The stabilizing slot (13) is provided at the front end of the inner side of the positioning bracket (7). The limiting protrusion (9) is provided on the outer side of the mounting plate (8). The second external lever (14) is provided at the front end of the outer side of the positioning bracket (7).

4. The optimized protein purification instrument according to claim 3, characterized in that, The positioning bracket (7) is L-shaped, and the interior of the limiting protrusion (9) and the stabilizing slot (13) fit together.

5. The optimized protein purification instrument of claim 1, wherein, The dustproof sealing structure includes a dustproof partition (3) and a stabilizing strip (12). The dustproof partition (3) is located on both sides of the rear end of the isolation cover (2) near the bottom. The stabilizing strip (12) is located on the rear end of the inner side of the dustproof partition (3), and a first outer lever (4) is located on the rear end of the outer side of the dustproof partition (3).

6. The optimized protein purification instrument of claim 5, wherein, The dustproof partition (3) corresponds to the heat dissipation groove (10) and is attached to the bottom of both sides of the protein purification instrument body (1), and the stabilizing clip (12) is inserted into the heat dissipation groove (10) located near the rear end of both sides of the bottom of the protein purification instrument body (1).

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