Purification device for medical intermediates

Abstract

The utility model belongs to the technical field of production of medical intermediates, and particularly discloses a purification device for medical intermediates, which comprises a supporting seat, a dissolving tank and two filter boxes, the two filter boxes are fixedly connected with two output ends of a first three-way electromagnetic valve, and a filter screen plate is obliquely arranged in each filter box. A cleaning door is hinged to one side of the filter box, a cleaning drain pipe is fixedly connected to the lower side of the filter box, a purification drain pipe is fixedly connected to the bottom of the filter box, and a cleaning mechanism is arranged in the filter box and comprises a plurality of nozzles, a cleaning pipe and a liquid pump. The two filter boxes are arranged, the first three-way electromagnetic valve and the second three-way electromagnetic valve are used for continuously changing the situation that dissolved liquid flows in and out of the two filter boxes respectively, one filter box is used for cleaning the other filter box, the downtime for cleaning the filter screen plates in the filter boxes is shortened, and the filter efficiency is improved. The reduction of the purification efficiency due to the influence of the cleaning operation is avoided.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical intermediate production technology, specifically a purification device for pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are chemical raw materials or products used in drug synthesis processes. Some solid pharmaceutical intermediates are crudely processed and contain numerous impurities, making them unsuitable for direct drug production. They require purification before use. Purification using recrystallization involves dissolving the pharmaceutical intermediate, filtering to remove insoluble impurities, and then crystallizing to obtain the purified intermediate. Existing purification devices for solid pharmaceutical intermediates require regular cleaning of the filters to prevent clogging and ensure proper operation. However, the filters are installed inside the filtration system, making cleaning difficult and requiring the purification process to be stopped, thus reducing efficiency. Therefore, a purification device for pharmaceutical intermediates that is easy to clean and does not affect purification efficiency during cleaning is needed. Utility Model Content

[0003] The purpose of this invention is to provide a purification device for pharmaceutical intermediates that is easy to clean and does not affect the efficiency of purification during cleaning, so as to solve the technical problem that the filter screen of the existing purification device is difficult to clean and affects the efficiency of normal purification.

[0004] To solve the above technical problems, the technical solution of this utility model is as follows: a purification device for pharmaceutical intermediates, including a support base, a dissolving tank, and a filter box. The bottom of the dissolving tank is fixedly connected to the top of the support base. The top of the dissolving tank has a feed inlet, the bottom is fixedly connected to an outlet pipe, and a stirring mechanism is provided inside. Two filter boxes are provided. The input ends of the two filter boxes are respectively fixedly connected to the two output ends of a first three-way solenoid valve through pipes. The input end of the first three-way solenoid valve is fixedly connected to the outlet pipe. A filter screen is inclinedly arranged inside the filter box. A cleaning door is hinged to one side of the filter box, a cleaning drain pipe is fixedly connected to the lower side, and a purification drain pipe is fixedly connected to the bottom. A cleaning mechanism is provided inside the filter box.

[0005] The cleaning mechanism includes several nozzles, cleaning pipes, and a liquid pump. Each filter box has a cleaning pipe fixedly connected to its outer side. The input ends of the two cleaning pipes are fixedly connected to the liquid supply pipe, and the other end of the liquid supply pipe is fixedly connected to the output end of the liquid pump. The input ends of the two cleaning pipes are respectively equipped with a first solenoid valve and a second solenoid valve. The input end of the nozzle is connected to the cleaning pipe, and the output end extends through into the filter box and is fixedly connected to the side wall of the filter box. All nozzles are located above the filter screen.

[0006] Furthermore, the stirring mechanism includes a motor and a stirring element. The motor is fixedly connected to the top of the dissolving tank, the upper end of the stirring element is rotatably connected to the inner top wall of the dissolving tank, and the output end of the motor is fixedly connected to the upper end of the stirring element.

[0007] Furthermore, the support base is fixedly connected to a horizontal mounting plate, and the bottom of the liquid pump and the bottom of the two filter boxes are fixedly connected to the top of the horizontal mounting plate.

[0008] Furthermore, the two purification drain pipes are respectively fixedly connected to the two input ends of the second three-way solenoid valve, and the output end of the second three-way solenoid valve is connected to the material collection pipeline through a pipe.

[0009] Furthermore, the cleaning door is located on the side of the filter screen that is tilted downwards, and the nozzles on both sides of the filter box are arranged parallel to the filter screen, with the lower side of the nozzles contacting the upper side of the filter screen.

[0010] This utility model has the following advantages compared with the prior art:

[0011] This invention features two filter boxes. A first three-way solenoid valve and a second three-way solenoid valve continuously regulate the flow of the dissolved liquid into and out of the two filter boxes. This allows for the use of one filter box while the other is being cleaned and kept in reserve, reducing downtime during filter cleaning and preventing the purification process from being negatively impacted by cleaning. Furthermore, a cleaning mechanism is installed within each filter box. Starting the liquid pump and opening the valves allows for rinsing of the filter plates. After rinsing, simply opening the cleaning door and removing the residue from the filter plates completes the cleaning process, significantly reducing the difficulty of the cleaning operation. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of this utility model.

[0013] Figure 2 This is a top view of the filter box of this utility model.

[0014] Figure 3 This is a right-side view of the present invention.

[0015] In the diagram: 1. Support base, 2. Dissolving tank, 3. Filter box, 4. First three-way solenoid valve, 5. Filter screen, 6. Cleaning door, 7. Cleaning drain pipe, 8. Purification drain pipe, 9. Discharge pipe, 10. Nozzle, 11. Cleaning pipe, 12. Liquid pump, 13. Liquid supply pipe, 14. First solenoid valve, 15. Second solenoid valve, 16. Motor, 17. Stirring component, 18. Horizontal mounting plate, 19. Second three-way solenoid valve. Detailed Implementation

[0016] The present invention will be further described below with reference to the accompanying drawings.

[0017] like Figures 1 to 3 The purification apparatus for pharmaceutical intermediates shown includes a support base 1, a dissolving tank 2, and filter boxes 3. The bottom of the dissolving tank 2 is fixedly connected to the top of the support base 1. An inlet pipe is connected to the upper side of the dissolving tank 2 for adding hot solvent into the dissolving tank 2. A feed inlet is opened at the top of the dissolving tank 2 for adding pharmaceutical intermediates. An outlet pipe 9 is fixedly connected to the bottom of the dissolving tank 2 to discharge the hot-dissolved material from the dissolving tank 2. A stirring mechanism is installed inside the dissolving tank 2. Two filter boxes 3 are provided, and the input ends of the two filter boxes 3 are respectively connected to a first three-way solenoid valve through pipes. The two output ends of 4 are fixedly connected. The input end of the first three-way solenoid valve 4 is fixedly connected to the outlet pipe 9. The filter box 3 is inclinedly equipped with a filter screen plate 5. A cleaning door 6 is hinged on one side of the filter box 3, a cleaning drain pipe 7 is fixedly connected to the lower side, and a purification drain pipe 8 is fixedly connected to the bottom. A pipe valve is installed on the cleaning drain pipe 7. A cleaning mechanism is set in the filter box 3. The dissolved material liquid is discharged from the outlet pipe 9 to the outside of the dissolving tank 2, enters the filter box 3 after passing through the first three-way solenoid valve 4, and is discharged from the purification drain pipe 8 after being filtered by the filter screen plate 5.

[0018] It should be noted that the first three-way solenoid valve 4 is a one-inlet, two-outlet diverting three-way solenoid valve, while the second three-way solenoid valve 19 mentioned later is a two-inlet, one-outlet merging three-way solenoid valve.

[0019] The cleaning mechanism includes several nozzles 10, cleaning pipes 11, and a liquid pump 12. Each filter box 3 is fixedly connected to a cleaning pipe 11 on its outside. The input ends of the two cleaning pipes 11 are fixedly connected to the liquid supply pipe 13. The other end of the liquid supply pipe 13 is fixedly connected to the output end of the liquid pump 12. The liquid pump 12 is connected to the cleaning liquid storage tank. Through the delivery of the liquid pump 12, the cleaning liquid is sent into the liquid supply pipe 13, and then through the cleaning pipe 11 and finally sprayed out from the nozzles 10 to clean the filter screen plate 5 in the filter box 3. The input ends of the two cleaning pipes 11 are respectively equipped with a first solenoid valve 14 and a second solenoid valve 15. The input end of the nozzle 10 is connected to the cleaning pipe 11, and the output end extends through into the filter box 3 and is fixedly connected to the side wall of the filter box 3. The nozzles 10 are all located above the filter screen plate 5.

[0020] In order to stir the materials and solvent in the dissolving tank 2 and accelerate the dissolution of the materials, the stirring mechanism includes a motor 16 and a stirring element 17. The motor 16 is fixedly connected to the top of the dissolving tank 2, the upper end of the stirring element 17 is rotatably connected to the inner top wall of the dissolving tank 2, and the output end of the motor 16 is fixedly connected to the upper end of the stirring element 17.

[0021] To facilitate the fixing of the filter box 3 and the liquid pump 12, the support base 1 is fixedly connected to the horizontal mounting plate 18, and the bottom of the liquid pump 12 and the bottom of the two filter boxes 3 are fixedly connected to the top of the horizontal mounting plate 18.

[0022] To facilitate the centralized delivery of the filtered material solution into the collection pipeline, two purification drain pipes 8 are fixedly connected to the two input ends of the second three-way solenoid valve 19, and the output end of the second three-way solenoid valve 19 is connected to the material collection pipeline through a pipeline.

[0023] In order to clean the residue on the filter screen plate 5 after cleaning, the cleaning door 6 is located on the side of the filter screen plate 5 that is tilted downward. In order to make the cleaning liquid sprayed from the nozzle 10 better rinse the filter screen plate 5, the nozzles 10 on both sides of the filter box 3 are arranged parallel to the filter screen plate 5, and the lower side of the nozzle 10 is in contact with the upper side of the filter screen plate 5.

[0024] The specific working process of this utility model is as follows:

[0025] The pharmaceutical intermediate to be purified is added into the dissolving tank 2 through the feed inlet, hot solvent is added, motor 16 is started, driving the stirring piece 17 to rotate, stirring the material and solvent in the dissolving tank 2. After dissolution is completed, the control switch opens the first three-way solenoid valve 4 and the second three-way solenoid valve 19. The dissolved liquid flows out from the outlet pipe 9, and after passing through the first three-way solenoid valve 4, it enters one of the filter boxes 3. The other filter box 3 is in an idle standby state at this time. After being filtered through the filter screen 5, it is discharged from the purification drain pipe 8, and after passing through the second three-way solenoid valve 19, it enters the collection pipeline and is sent to the next process.

[0026] When the filter screen 5 inside the used filter box 3 needs to be cleaned, the control switch switches the first three-way solenoid valve 4 and the second three-way solenoid valve 19 to open another passage. At this time, the solution flowing out of the dissolving tank 2 enters another spare filter box 3 through the other passage of the first three-way solenoid valve 4. After filtration, it enters the collection pipeline through the other passage of the second three-way solenoid valve 19. The previously used filter box 3 is now idle and waiting to be cleaned. At this time, the valve on the cleaning drain pipe 7 on the filter box 3 to be cleaned is opened, the control switch opens the first solenoid valve 14 and closes the second solenoid valve 15, and the liquid pump 12 is started to pump the cleaning solution. The cleaning solution is sent to the installation pipeline through the supply pipe 13, the first solenoid valve 14, and the cleaning pipe 11 in sequence. The cleaning solution is sprayed from the nozzle 10 on the side wall of the filter box 3 to clean the filter screen plate 5, and the residue is gradually washed to the downward tilted side of the filter screen plate 5. After cleaning, the cleaning solution flows out of the filter box 3 from the cleaning drain pipe 7. After rinsing, the liquid pump 12 is turned off, the cleaning door 6 is opened, and the residue on the filter screen plate 5 is cleaned out of the filter box 3 from the cleaning door 6. The cleaning door 6 is closed to complete the cleaning. The first solenoid valve 14 is closed, and the valve on the cleaning drain pipe 7 is closed. The cleaned filter box 3 is then left idle for standby. Similarly, when cleaning another filter box 3, the above steps remain unchanged, except that the control is changed to open the second solenoid valve 15 and close the first solenoid valve 14 to clean the other filter box. This cycle is repeated.

Claims

1. A purification device for pharmaceutical intermediates, comprising a support base (1), a dissolving tank (2), and a filter box (3), wherein the bottom of the dissolving tank (2) is fixedly connected to the top of the support base (1), the top of the dissolving tank (2) is provided with a feed inlet, the bottom is fixedly connected with a liquid outlet pipe (9), and a stirring mechanism is provided inside, characterized in that: Two filter boxes (3) are provided. The input ends of the two filter boxes (3) are fixedly connected to the two output ends of the first three-way solenoid valve (4) through pipes respectively. The input end of the first three-way solenoid valve (4) is fixedly connected to the liquid outlet pipe (9). A filter screen plate (5) is inclinedly arranged inside the filter box (3). A cleaning door (6) is hinged on one side of the filter box (3), a cleaning drain pipe (7) is fixedly connected to the lower side, and a purification drain pipe (8) is fixedly connected to the bottom. A cleaning mechanism is provided inside the filter box (3). The cleaning mechanism includes several nozzles (10), cleaning pipes (11), and a liquid pump (12). Each filter box (3) is fixedly connected to a cleaning pipe (11) on its outside. The input ends of the two cleaning pipes (11) are fixedly connected to the liquid supply pipe (13). The other end of the liquid supply pipe (13) is fixedly connected to the output end of the liquid pump (12). The input ends of the two cleaning pipes (11) are respectively equipped with a first solenoid valve (14) and a second solenoid valve (15). The input end of the nozzle (10) is connected to the cleaning pipe (11), and the output end extends through into the filter box (3) and is fixedly connected to the side wall of the filter box (3). The nozzles (10) are all located above the filter screen plate (5).

2. The purification device for pharmaceutical intermediates according to claim 1, characterized in that: The stirring mechanism includes a motor (16) and a stirring element (17). The motor (16) is fixedly connected to the top of the dissolving tank (2). The upper end of the stirring element (17) is rotatably connected to the inner top wall of the dissolving tank (2). The output end of the motor (16) is fixedly connected to the upper end of the stirring element (17).

3. The purification device for pharmaceutical intermediates according to claim 1, characterized in that: The support base (1) is fixedly connected to a horizontal mounting plate (18), and the bottom of the liquid pump (12) and the bottom of the two filter boxes (3) are fixedly connected to the top of the horizontal mounting plate (18).

4. The purification device for pharmaceutical intermediates according to claim 1, characterized in that: The two purification drain pipes (8) are fixedly connected to the two input ends of the second three-way solenoid valve (19), and the output end of the second three-way solenoid valve (19) is connected to the material collection pipeline through a pipeline.

5. The purification device for pharmaceutical intermediates according to claim 1, characterized in that: The cleaning door (6) is located on the side of the filter screen (5) that is tilted downwards. The nozzles (10) on both sides of the filter box (3) are arranged parallel to the filter screen (5). The lower side of the nozzles (10) is in contact with the upper side of the filter screen (5).

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