Reduced-pressure drying device for upatinib

Abstract

The utility model discloses a reduced-pressure drying device for upatinib, and relates to the technical field of chemical medicine production equipment. Comprising a fixed base, a pressure reduction drying tank is arranged on the upper portion of the fixed base, the upper end of the pressure reduction drying tank communicates with an upper negative pressure pipeline, the lower end of the pressure reduction drying tank communicates with a lower negative pressure pipeline, the upper negative pressure pipeline communicates with the lower negative pressure pipeline through an air dehumidification tank, and one side of the air dehumidification tank communicates with an air negative pressure pump; an electromagnetic pressure release valve is arranged in the middle of the side wall of the pressure reduction drying tank, a cross-shaped structure of a containing frame, air holes in the bottom of a drying disc and filter cloth can enhance circulation of upatinib powder at the bottom of the drying disc and an inner cavity of the pressure reduction drying tank, and the drying efficiency is improved; the air negative pressure pump enables the drying disc to flow between the ventilation holes of the air blocking disc at a constant speed, and prevents the situation that when the air negative pressure pump works, generated airflow acts on the fixing position of the drying disc through the ventilation holes, and consequently drying is uneven.

Description

Technical Field

[0001] This utility model relates to the field of chemical and pharmaceutical production equipment technology, specifically to a vacuum drying device for utpatinib. Background Technology

[0002] Patinib is an oral JAK1 inhibitor used to treat diseases such as rheumatoid arthritis and psoriatic arthritis. JAK kinases are a family of non-receptor tyrosine kinases, with four members identified: JAK1, JAK2, JAK3, and TYK1. JAK substrates are STATs, signal transducers and transcription activators. STATs dimerize after being phosphorylated by JAKs, then cross the nuclear membrane into the nucleus to regulate the expression of related genes. This signaling pathway is called the JAK-STAT pathway. Therefore, JAKs play an important role in immune-mediated disease pathophysiology and can be used to treat some autoimmune diseases such as atopic dermatitis, rheumatoid arthritis, psoriasis, and ulcerative colitis.

[0003] Patent document CN212299686U discloses a pressure-reducing device for a vacuum dryer, including a vacuum dryer body. An exhaust pipe is connected to the lower right end of the vacuum dryer body, and a pressure-reducing pipe is connected to the right side of the exhaust pipe. A first support rod is fixedly installed at the top and bottom of the right end of the inner cavity of the pressure-reducing pipe. This invention, through the arrangement of the vacuum dryer body, exhaust pipe, pressure-reducing pipe, first support rod, mounting block, fan blade, first servo motor, conical drill bit, fixing plate, connecting pipe, second servo motor, rotating rod, sleeve, pushing rod, and piston plate, effectively improves the pressure-reducing effect. It solves the problems of poor pressure-reducing effect in existing vacuum dryers, the simple structure of traditional pressure-reducing devices, the large exhaust pressure which can easily injure workers during pressure reduction, and the reduced stability and impact on subsequent work efficiency.

[0004] Although the aforementioned patent can improve the stability of pressure reduction in the vacuum dryer body, its pressure reduction working position is singular. This results in materials placed near the pressure reduction and exhaust position having a better drying effect than materials placed far away from it, leading to uneven drying of the materials. Furthermore, when materials are piled up in the vacuum dryer body, the air in the vacuum dryer body cannot circulate evenly and stably between the materials, and the airflow cannot carry away the moisture that evaporates after the materials pass through the negative pressure in a timely manner, resulting in low drying efficiency.

[0005] Therefore, we have made improvements to this by proposing a vacuum drying device for utpatinib. Utility Model Content

[0006] To address the shortcomings of existing technologies, this invention provides a vacuum drying device for utpatinib, which solves the problems of uneven material drying and low drying efficiency in existing vacuum drying devices.

[0007] To achieve the above objectives, this utility model is implemented through the following technical solution: a depressurization drying device for utpatinib, comprising a fixed base, a depressurization drying tank provided on the upper part of the fixed base, an upper negative pressure pipe connected to the upper end of the depressurization drying tank, a lower negative pressure pipe connected to the lower end of the depressurization drying tank, the upper negative pressure pipe and the lower negative pressure pipe being connected through an air dehumidification tank, an air negative pressure pump connected to one side of the air dehumidification tank, and an electromagnetic pressure relief valve provided in the middle of the side wall of the depressurization drying tank;

[0008] The inner cavity of the vacuum drying tank is provided with multiple evenly distributed placement racks arranged longitudinally along the axis of the vacuum drying tank, and a drying tray is placed on the upper part of the placement racks.

[0009] As a preferred embodiment, the inner cavity of the pressure-reducing drying tank is horizontally fixed with baffle plates at both the upper and lower ends, and the outer edge of the baffle plates is provided with multiple evenly arranged ventilation holes.

[0010] As a preferred embodiment, a baffle plate located at the lower end of the inner cavity of the vacuum drying tank is fixedly mounted on a stepper motor, and a rotating shaft is fixedly mounted on the rotating shaft of the stepper motor. The upper part of the rotating shaft is rotatably mounted with the baffle plate located at the upper end of the inner cavity of the vacuum drying tank.

[0011] As a preferred embodiment, multiple placement racks are evenly and fixedly arranged vertically on the rotating shaft. The placement racks are cross-shaped plate structures, and the middle part of the placement racks is fixedly fitted to the rotating shaft.

[0012] As a preferred embodiment, the bottom of the drying tray is provided with multiple evenly distributed air vents, and the bottom of the inner cavity of the drying tray is lined with filter cloth.

[0013] The drying tray has a placement groove along its radial direction. The front end of the placement groove is connected to the outer edge of the drying tray. The two sides and the end of the placement groove are closed and spaced from the inner cavity of the drying tray by a sealing plate.

[0014] As a preferred embodiment, the inner cavity of the air dehumidifier is filled with activated charcoal, an upper connecting pipe is provided on the upper part of one side of the air dehumidifier, a lower connecting pipe is provided on the lower part of one side of the air dehumidifier, the upper connecting pipe and the lower connecting pipe are arranged opposite to each other, the upper connecting pipe is connected to the upper negative pressure pipe, and the lower connecting pipe is connected to the lower negative pressure pipe.

[0015] The air dehumidifier is connected to the middle of the side wall opposite the upper and lower connecting pipes by a main connecting pipe, which is connected to an air negative pressure pump.

[0016] As a preferred embodiment, the sidewalls of the upper connecting pipe, lower connecting pipe, and main connecting pipe that connect to the air negative pressure pump are provided with multiple evenly distributed mesh holes.

[0017] As a preferred embodiment, the upper part of the air dehumidification tank is connected to an inlet pipe, and the lower part of the air dehumidification tank is connected to an outlet pipe, with rubber plugs tightly inserted into the inner cavities of the inlet pipe and the outlet pipe.

[0018] As a preferred embodiment, the side wall of the vacuum drying tank is hinged with a sealing door.

[0019] As a preferred embodiment, a support frame is fixedly provided on the upper side of the fixed base, and the upper part of the support frame is fixedly supported to the air negative pressure pump.

[0020] This utility model has the following beneficial effects:

[0021] Place the utpatinib powder to be dried in the drying tray, and then place the drying tray on the rack. The drying tray is inserted into the shaft through the placement slot to avoid interference between the drying tray and the shaft, which would prevent the drying tray from being placed on the rack. The cross-shaped structure of the rack, the air vents and filter cloth at the bottom of the drying tray can enhance the flow of utpatinib powder at the bottom of the drying tray and the inner cavity of the vacuum drying tank, thereby improving the drying efficiency.

[0022] The stepper motor and the rotating shaft drive the drying tray to rotate slowly and evenly, so that the utpatinib powder in the drying tray flows evenly between the ventilation holes of the baffle plate. This prevents the airflow generated by the negative pressure pump from acting on the fixed position of the drying tray through the ventilation holes, which would otherwise cause uneven drying.

[0023] The negative pressure air pump simultaneously applies negative pressure to the inner cavities at both ends of the vacuum drying tank through the upper and lower negative pressure pipes, so that the air pressure at both ends of the vacuum drying tank can be smoothly transitioned during the decompression process. This allows the moisture in the utpatinib powder to evaporate smoothly into the inner cavity of the vacuum drying tank. Then, the electromagnetic pressure relief valve controls the entry of external air into the vacuum drying tank to form an airflow, which draws the air containing moisture out of the vacuum drying tank through the negative pressure air pump.

[0024] The dehumidifier can absorb moisture from the air entering the negative pressure air pump from the depressurization drying tank, preventing moisture from corroding the negative pressure air pump.

[0025] Of course, any product implementing this utility model does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of the overall structure of a vacuum drying device for utpatinib according to this utility model.

[0027] Figure 2 This is a schematic cross-sectional view of the vacuum drying tank of the vacuum drying device for utpatinib according to this utility model.

[0028] Figure 3 This is a schematic diagram of the baffle plate structure of a decompression drying device for utpatinib according to this utility model;

[0029] Figure 4 This is a schematic diagram of the placement rack structure of the vacuum drying device for utpatinib according to this utility model;

[0030] Figure 5 This is a schematic diagram of the drying tray structure of a vacuum drying device for utpatinib according to this utility model;

[0031] Figure 6 This is a schematic diagram of the air dehumidification tank structure of a pressure-reducing drying device for utpatinib according to this utility model;

[0032] In the diagram: 1. Fixed base; 2. Pressure-reducing drying tank; 3. Upper negative pressure pipe; 4. Lower negative pressure pipe; 5. Air dehumidification tank; 6. Air negative pressure pump; 7. Placement rack; 8. Drying tray; 9. Wind baffle plate; 10. Ventilation hole; 11. Stepper motor; 12. Rotating shaft; 13. Ventilation hole; 14. Filter cloth; 15. Placement slot; 16. Sealing plate; 17. Electromagnetic pressure relief valve; 18. Upper connecting pipe; 19. Lower connecting pipe; 20. Main connecting pipe; 21. Feed pipe; 22. Discharge pipe; 23. Rubber stopper; 24. Sealing door; 25. Support frame. Detailed Implementation

[0033] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0034] In the description of this utility model, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "around" and other terms indicating orientation or positional relationship are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0035] Please refer to the examples. Figures 1 to 6This utility model provides a technical solution: a depressurization drying device for utpatinib, including a fixed base 1, a depressurization drying tank 2 on the upper part of the fixed base 1, an upper negative pressure pipe 3 connected to the upper end of the depressurization drying tank 2, a lower negative pressure pipe 4 connected to the lower end of the depressurization drying tank 2, the upper negative pressure pipe 3 and the lower negative pressure pipe 4 being connected through an air dehumidification tank 5, an air negative pressure pump 6 connected to one side of the air dehumidification tank 5, and an electromagnetic pressure relief valve 17 in the middle of the side wall of the depressurization drying tank 2;

[0036] The inner cavity of the vacuum drying tank 2 is provided with multiple evenly distributed placement racks 7 arranged longitudinally along the axis of the vacuum drying tank 2, and a drying tray 8 is placed on the upper part of the placement rack 7.

[0037] The inner cavity of the pressure-reducing drying tank 2 is horizontally fixed with a baffle plate 9 at both the upper and lower ends, and the outer edge of the baffle plate 9 is provided with a plurality of evenly arranged ventilation holes 10.

[0038] The baffle plate 9, located at the lower end of the inner cavity of the pressure-reducing drying tank 2, is fixedly mounted on the stepper motor 11. The rotating shaft of the stepper motor 11 is fixedly mounted on the rotating shaft 12. The upper part of the rotating shaft 12 is rotatably mounted with the baffle plate 9 located at the upper end of the inner cavity of the pressure-reducing drying tank 2.

[0039] Multiple placement racks 7 are evenly and fixedly arranged vertically on the rotating shaft 12. The placement rack 7 has a cross-shaped plate structure, and the middle part of the placement rack 7 is fixedly fitted to the rotating shaft 12.

[0040] The bottom of the drying tray 8 is provided with a plurality of evenly distributed air vents 13, and the bottom of the inner cavity of the drying tray 8 is lined with filter cloth 14.

[0041] The drying tray 8 is provided with a placement groove 15 along the radial direction of the drying tray 8. The front end of the placement groove 15 is connected to the outer edge of the drying tray 8. The two sides and the end of the placement groove 15 are closed and spaced from the inner cavity of the drying tray 8 by a sealing plate 16.

[0042] The inner cavity of the air dehumidifier 5 is filled with activated charcoal. An upper connecting pipe 18 is connected to the upper part of one side of the air dehumidifier 5, and a lower connecting pipe 19 is provided at the lower part of one side of the air dehumidifier 5. The upper connecting pipe 18 and the lower connecting pipe 19 are arranged opposite to each other. The upper connecting pipe 18 is connected to the upper negative pressure pipe 3, and the lower connecting pipe 19 is connected to the lower negative pressure pipe 4.

[0043] The air dehumidifier 5 is connected to the middle of the side wall opposite to the upper connecting pipe 18 and the lower connecting pipe 19 by a main connecting pipe 20, which is connected to the air negative pressure pump 6.

[0044] The sidewalls of the upper connecting pipe 18, lower connecting pipe 19 and main connecting pipe 20 that are connected to the air negative pressure pump 6 are provided with multiple evenly distributed mesh holes.

[0045] The upper part of the air dehumidification tank 5 is connected to the feed pipe 21, and the lower part of the air dehumidification tank 5 is connected to the discharge pipe 22. The inner cavities of the feed pipe 21 and the discharge pipe 22 are tightly fitted with rubber plugs 23.

[0046] The side wall of the pressure-reducing drying tank 2 is hinged with a sealing door 24.

[0047] A support frame 25 is fixedly provided on one side of the upper part of the fixed base 1, and the upper part of the support frame 25 is fixedly supported by the air negative pressure pump 6.

[0048] The working principle of this utility model:

[0049] The utpatinib powder to be dried is placed in the drying tray 8, and then the drying tray 8 is placed on the placement rack 7. The drying tray 8 is inserted into the rotating shaft 12 through the placement groove 15 to avoid interference between the drying tray 8 and the rotating shaft 12, so that the drying tray 8 can not be placed on the placement rack 7. The cross-shaped structure of the placement rack 7, together with the vent holes 13 and filter cloth 14 at the bottom of the drying tray 8, can enhance the flow of utpatinib powder at the bottom of the drying tray 8 and the inner cavity of the vacuum drying tank 2, thereby improving the drying efficiency.

[0050] When the sealing door 24 is closed, the stepper motor 11 and the rotating shaft 12 drive the drying tray 8 to rotate slowly and uniformly, so that the utpatinib powder in the drying tray 8 flows uniformly between the ventilation holes 10 of the baffle plate 9, preventing the airflow generated by the negative pressure pump 6 from acting on the fixed position of the drying tray 8 through the ventilation holes 10, thus causing uneven drying.

[0051] The negative pressure air pump 6 applies negative pressure to the inner cavities of the upper and lower ends of the pressure-reducing drying tank 2 simultaneously through the upper negative pressure pipe 3 and the lower negative pressure pipe 4, so that the air pressure at both ends of the pressure-reducing drying tank 2 can be smoothly transitioned during the pressure reduction process. This allows the moisture in the utpatinib powder to evaporate smoothly into the inner cavity of the pressure-reducing drying tank 2. Then, the electromagnetic pressure relief valve 17 controls the entry of external air into the pressure-reducing drying tank 2 to form an airflow. The air containing moisture in the pressure-reducing drying tank 2 is drawn out of the pressure-reducing drying tank 2 by the negative pressure air pump 6. The air dehumidification tank 5 can absorb the moisture in the air entering the negative pressure air pump 6 from the pressure-reducing drying tank 2, preventing the moisture from corroding the negative pressure air pump 6.

[0052] The air negative pressure pump 6 works in conjunction with the electromagnetic pressure relief valve 17 to repeat the above steps multiple times. After the set drying time is completed, the sealing door 24 will be opened and the drying tray 8 will be taken out.

[0053] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0054] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A vacuum drying apparatus for utpatinib, characterized in that: Includes a fixed base (1), a pressure-reducing drying tank (2) is provided on the upper part of the fixed base (1), an upper negative pressure pipe (3) is connected to the upper end of the pressure-reducing drying tank (2), a lower negative pressure pipe (4) is connected to the lower end of the pressure-reducing drying tank (2), the upper negative pressure pipe (3) and the lower negative pressure pipe (4) are connected through an air dehumidification tank (5), an air negative pressure pump (6) is connected to one side of the air dehumidification tank (5), and an electromagnetic pressure relief valve (17) is provided in the middle of the side wall of the pressure-reducing drying tank (2). The inner cavity of the vacuum drying tank (2) is provided with multiple evenly distributed placement racks (7) arranged longitudinally along the axis of the vacuum drying tank (2), and a drying tray (8) is placed on the upper part of the placement rack (7).

2. The vacuum drying apparatus for utpatinib according to claim 1, characterized in that: The inner cavity of the pressure-reducing drying tank (2) is horizontally fixed with a baffle plate (9) at both the upper and lower ends, and the outer edge of the baffle plate (9) is provided with a plurality of evenly arranged ventilation holes (10).

3. The vacuum drying apparatus for utpatinib according to claim 1, characterized in that: The baffle plate (9) located at the lower end of the inner cavity of the pressure-reducing drying tank (2) is fixedly mounted on the stepper motor (11). The shaft of the stepper motor (11) is fixedly mounted on the shaft (12). The upper part of the shaft (12) is rotatably mounted on the baffle plate (9) located at the upper end of the inner cavity of the pressure-reducing drying tank (2).

4. The vacuum drying apparatus for utpatinib according to claim 3, characterized in that: Multiple placement racks (7) are evenly and fixedly arranged vertically on the rotating shaft (12). The placement rack (7) is a cross-shaped plate structure, and the middle part of the placement rack (7) is fixedly fitted with the rotating shaft (12).

5. The vacuum drying apparatus for utpatinib according to claim 1, characterized in that: The bottom of the drying tray (8) is provided with a plurality of evenly distributed air vents (13), and the bottom of the inner cavity of the drying tray (8) is covered with filter cloth (14). The drying tray (8) is provided with a placement groove (15) along the radial direction of the drying tray (8). The front end of the placement groove (15) is connected to the outer edge of the drying tray (8). The two sides and the end of the placement groove (15) are closed and spaced from the inner cavity of the drying tray (8) by a sealing plate (16).

6. The vacuum drying apparatus for utpatinib according to claim 1, characterized in that: The inner cavity of the air dehumidifier (5) is filled with activated charcoal. An upper connecting pipe (18) is connected to the upper part of one side of the air dehumidifier (5), and a lower connecting pipe (19) is provided on the lower part of one side of the air dehumidifier (5). The upper connecting pipe (18) and the lower connecting pipe (19) are arranged opposite to each other. The upper connecting pipe (18) is connected to the upper negative pressure pipe (3), and the lower connecting pipe (19) is connected to the lower negative pressure pipe (4). The air dehumidifier (5) is connected to the middle of the side wall opposite to the upper connecting pipe (18) and the lower connecting pipe (19) by a main connecting pipe (20), which is connected to the negative pressure air pump (6).

7. The vacuum drying apparatus for utpatinib according to claim 6, characterized in that: The upper connecting pipe (18), lower connecting pipe (19) and main connecting pipe (20) are provided with multiple evenly distributed mesh holes on the side wall connecting to the air negative pressure pump (6).

8. The vacuum drying apparatus for utpatinib according to claim 1, characterized in that: The upper part of the air dehumidification tank (5) is connected to the feed pipe (21), and the lower part of the air dehumidification tank (5) is connected to the discharge pipe (22). The inner cavities of the feed pipe (21) and the discharge pipe (22) are tightly fitted with rubber plugs (23).

9. The vacuum drying apparatus for utpatinib according to claim 1, characterized in that: The side wall of the vacuum drying tank (2) is hinged with a sealing door (24).

10. The vacuum drying apparatus for utpatinib according to claim 1, characterized in that: A support frame (25) is fixedly provided on one side of the upper part of the fixed base (1), and the upper part of the support frame (25) is fixedly supported by the air negative pressure pump (6).

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