Chromatographic filler filling device

Abstract

The utility model relates to a chromatographic packing filling device, which relates to the technical field of chromatographic column quantitative packing, and comprises a rack, a hopper is mounted on the rack, the bottom of the hopper is communicated with a discharge pipeline, and a proportional valve is mounted on the discharge pipeline. A column pipe of the chromatographic column is detachably mounted between the elastic supporting mechanism and the discharging pipeline, and the positioning mechanisms are clamped and fixed on two sides of the column pipe of the chromatographic column. According to the invention, the convenience of filling the chromatographic column with the filler by an operator by using the column packing machine can be improved.

Description

A chromatographic packing device Technical Field

[0001] This application relates to the field of quantitative packing technology for chromatographic columns, and in particular to a packing device for chromatographic columns. Background Technology

[0002] Liquid chromatography (LC) is currently one of the most commonly used separation and purification techniques. Classified by operating pressure, LC can be divided into low-pressure, medium-pressure, high-pressure, and ultra-high-pressure chromatography. Among these, low- and medium-pressure chromatography (pressure 1-20 kgf) is widely used due to its ease of implementation, simplicity, and low cost. The column packing technique is a crucial factor affecting the efficiency of chromatographic analysis. For low- and medium-pressure chromatography, because the packing particles are generally larger than 30 μm, dry packing is often used.

[0003] In existing technologies, common column packing machines mainly consist of a frame and a hopper. A discharge pipe is installed at the bottom of the hopper for the packing material to flow out, and a metering valve is installed on the discharge pipe to control the quantitative flow of the packing material. During the packing process, the operator needs to place the column tube below the discharge pipe and inject the packing material quantitatively into the column tube by controlling the metering valve. To ensure the stability of the column tube, the operator needs to manually hold the column tube during the packing process, which is inconvenient and requires improvement. Summary of the Invention

[0004] To improve the ease of use for operators when filling chromatographic columns with packing materials using a column packer, this application provides a chromatographic packing device.

[0005] The chromatographic packing device provided in this application adopts the following technical solution:

[0006] A chromatographic packing device includes a frame, a hopper mounted on the frame, a discharge pipe connected to the bottom of the hopper, and a metering valve mounted on the discharge pipe. The device is characterized in that an elastic support mechanism and a positioning mechanism are mounted on the frame, the upper and lower ends of a chromatographic column are detachably mounted between the elastic support mechanism and the discharge pipe, and the positioning mechanism clamps and fixes both sides of the chromatographic column.

[0007] By adopting the above technical solution, when filling a chromatographic column with packing material using a column packer, the operator can pre-install the upper and lower ends of the column tube on the elastic support mechanism, and then position the left and right sides of the column tube using the positioning mechanism. During the process of the packing material flowing into the column tube from the hopper via the discharge pipe, the operator is freed from manually holding the column tube, effectively improving the convenience of using the packing device for packing operations.

[0008] Preferably, the frame includes a mounting base with a slot located directly below the discharge pipe;

[0009] A first spring is fixedly installed at the bottom of the slot, and a carrier is fixedly installed at the top of the first spring. The top of the carrier has a positioning groove that matches the bottom of the chromatographic column, and the carrier is slidably disposed in the slot.

[0010] The slot has an extension extending inward from the opening, and the extension is positioned at the top of the base.

[0011] By adopting the above technical solution, when connecting the column tube, the operator can insert the bottom of the column tube into the positioning groove on the carrier. Pressing down on the carrier causes the column tube to move downwards, making it easy for the operator to position the end of the column tube directly below the discharge pipe. Used in conjunction with the positioning mechanism, the left and right sides of the column tube can be fixed, thus achieving column positioning. After the column tube is fixed, the operator can activate the metering valve to fill the column tube with a measured amount of chromatographic packing material. During the packing process, the operator is freed from manually holding the column tube, improving the convenience of using the packing device to fill the column. The extension section limits the maximum height of the carrier, preventing the carrier from detaching from the slot.

[0012] Preferably, the frame includes a top plate, and a through hole is provided on the top plate for the discharge pipe to extend out;

[0013] A second spring is fixedly connected to the top plate. The second spring is coaxially sleeved on the outside of the discharge pipe. A ring cover is coaxially sleeved on the discharge pipe. The top of the ring cover is fixedly connected to the bottom of the second spring. The ring cover abuts against the top of the column tube of the chromatographic column and the second spring.

[0014] By adopting the above technical solution, the second spring generates a downward elastic force, causing the ring cap at the bottom of the second spring to cover the opening of the column tube, which can reduce the occurrence of dust escaping from the chromatographic packing material during the packing process.

[0015] Preferably, the bottom edge of the ring cover is fixedly connected with an edge.

[0016] By adopting the above technical solution, the edge is covered on the outside of the joint between the ring cap and the column tube, which can further improve the sealing performance of the ring cap.

[0017] Preferably, the positioning mechanism includes a first clamping member and a second clamping member. The first clamping member is fixedly installed on the frame, and the second clamping member is slidably installed on the second clamping member. Both the first clamping member and the second clamping member are fixedly connected to an elastic positioning block on the side of the column tube near the chromatographic column, and a positioning port adapted to the column tube of the chromatographic column is formed between the two elastic positioning blocks.

[0018] A guide rod is fixedly connected to the second clamping member, and a through hole is provided on the first clamping member for the guide rod to pass through. A third spring is coaxially sleeved on the guide rod, and the third spring abuts against the first clamping member and the second clamping member.

[0019] A telescopic cylinder is fixedly connected to the frame. The drive shaft end of the telescopic cylinder is fixedly connected to the second clamping member. A start button and a reset button are fixedly installed on the mounting plate. The signal output ends of the start button and the reset button are connected to the signal input ends of the telescopic cylinder.

[0020] By adopting the above technical solution, when the operator mounts the bottom of the column tube on the carrier, places the end of the column tube over the outside of the outlet pipe, and covers the end of the column tube with the ring cap, the operator can input a start signal via the start button. Upon receiving the start signal, the telescopic cylinder drives the second clamping member to move closer to the first clamping member. The first and second clamping members clamp and position the left and right sides of the column tube. The rubber positioning blocks on the first and second clamping members ensure that the rubber positioning blocks are firmly clamped between the two sides of the column tube and the first and second clamping members, reducing the adverse effects of the clamping action on the column tube. After the chromatographic packing material is filled, the operator can input a reset signal via the reset button. Upon receiving the reset signal, the telescopic cylinder retracts its drive shaft, causing the second clamping member to slide away from the first clamping member, facilitating the operator's removal of the column tube from between the first and second clamping members. Because a third spring is provided between the first clamping member and the second clamping member, the third spring improves the stability of the sliding action of the second clamping member as the second clamping member approaches the first clamping member, and can accelerate the reset of the second clamping member as the second clamping member moves away from the first clamping member.

[0021] Preferably, a mounting plate is fixedly connected to the frame, the first clamping member is fixedly mounted on the mounting plate, an anti-detachment rail is fixedly connected to the mounting plate, the anti-detachment rail is arranged in an inverted trapezoidal shape, a limiting groove adapted to the rail is opened at the bottom of the second clamping member, and the second clamping member is slidably mounted on the anti-detachment rail.

[0022] By adopting the above technical solution, and by setting up anti-detachment rails and limiting slides, the technical effect of the second clamping component sliding on the mounting plate can be achieved, while reducing the occurrence of the second clamping component falling off the mounting plate.

[0023] In summary, the chromatographic packing device of this application has at least one of the following beneficial technical effects:

[0024] 1. When using a column packer to fill a chromatographic column with packing material, the operator can pre-install the upper and lower ends of the column tube on the elastic support mechanism, and then position the left and right sides of the column tube using the positioning mechanism. As the packing material in the hopper flows into the column tube through the discharge pipe, the operator is not required to hold the column tube by hand, which can effectively improve the convenience of the operator in using the packing device to fill the chromatographic column with packing material.

[0025] 2. By setting the second spring, the second spring generates a downward elastic force, so that the ring cap at the bottom of the second spring covers the tube opening of the column tube, which can reduce the occurrence of dust escaping from the chromatographic packing material during the packing process. Attached Figure Description

[0026] Figure 1 is a schematic diagram illustrating the overall structure of the filling device according to an embodiment of this application.

[0027] Figure 2 is a schematic diagram illustrating the internal structure of the filling device according to an embodiment of this application.

[0028] Figure 3 is an enlarged schematic diagram of point A-1 in Figure 2, mainly used to show the installation position of the ring cover.

[0029] Figure 4 is an enlarged schematic diagram of point A-2 in Figure 1, mainly used to show the installation structure of the first clamping component and the second clamping component.

[0030] Explanation of reference numerals in the attached drawings: 1. Frame; 11. Mounting base; 12. Slot; 13. First spring; 14. Carrier; 15. Positioning slot; 16. Extension; 17. Second spring; 18. Ring cover; 19. Edge; 2. Hopper; 21. Discharge pipe; 3. Metering valve; 5. Positioning mechanism; 51. First clamping element; 52. Second clamping element; 53. Elastic positioning block; 54. Guide rod; 55. Third spring; 56. Telescopic cylinder; 6. Column tube; 7. Mounting plate; 71. Anti-derailment track; 72. Start button; 73. Reset button. Detailed Implementation

[0031] The present application will be further described in detail below with reference to Figures 1-4.

[0032] Example

[0033] This application discloses a chromatographic packing device. Referring to Figures 1-4, it mainly includes a frame 1, a hopper 2 mounted on the frame 1, a discharge pipe 21 connected to the bottom of the hopper 2, and a metering valve 3 mounted on the discharge pipe 21. The device is characterized in that an elastic support mechanism and a positioning mechanism 5 are mounted on the frame 1, and the upper and lower ends of the chromatographic column tube 6 are detachably mounted between the elastic support mechanism and the discharge pipe 21. The positioning mechanism 5 clamps and fixes the chromatographic column tube 6 on both sides.

[0034] When using a column packer to fill a chromatographic column with chromatographic packing material, the operator can pre-install the upper and lower ends of the column tube 6 on the elastic support mechanism, and then use the positioning mechanism 5 to position the left and right sides of the column tube 6.

[0035] During the process of the chromatographic packing material in the hopper 2 flowing into the column tube 6 of the chromatographic column through the discharge pipe 21, the operator is not required to hold the column tube 6 by hand, which can effectively improve the convenience of the operator to use the packing device to fill the chromatographic packing material.

[0036] Referring to Figures 1-3, the frame 1 includes a mounting base 11, on which a slot 12 is provided. The slot 12 is located directly below the discharge pipe 21. A first spring 13 is fixedly installed at the bottom of the slot 12, and a carrier 14 is fixedly installed at the top of the first spring 13. A positioning groove 15 adapted to the bottom of the chromatographic column is provided at the top of the carrier 14, and the carrier 14 is slidably disposed in the slot 12. An extension 16 is provided extending inward from the opening of the slot 12, and the extension 16 is limited at the top of the carrier 14.

[0037] When connecting the column tube 6 of the chromatographic column, the operator can insert the bottom of the column tube 6 into the positioning groove 15 on the carrier 14. After pressing down the carrier 14 to move the column tube 6 down, the operator can easily position the end of the column tube 6 directly below the discharge pipe 21. When used with the positioning mechanism 5, the left and right sides of the column tube 6 can be fixed, thereby achieving the positioning of the column tube 6.

[0038] After the column tube 6 is secured, the operator can activate the metering valve 3 to fill the column tube 6 with a measured amount of chromatographic packing material. During the packing process, the operator is no longer required to manually hold the column tube 6, improving the ease of use for filling the column with packing material. The extension 16 limits the maximum height of the carrier 14, preventing it from detaching from the slot 12.

[0039] It should be noted that in this embodiment, the frame 1 includes a base plate, and the mounting base 11 is fixed to the base plate by welding.

[0040] Referring to Figures 2 and 3, the frame 1 includes a top plate with a through hole for the discharge pipe 21 to extend through. A second spring 17 is fixedly connected to the top plate and is coaxially sleeved on the outside of the discharge pipe 21. A ring cover 18 is coaxially sleeved on the discharge pipe 21. The top of the ring cover 18 is fixedly connected to the bottom of the second spring 17 and the ring cover 18 abuts against the top of the column tube 6 of the chromatographic column and the second spring 17.

[0041] By setting the second spring 17, the second spring 17 generates a downward elastic force, so that the ring cap 18 at the bottom of the second spring 17 covers the opening of the column tube 6, which can reduce the occurrence of dust escaping from the chromatographic packing during the packing process.

[0042] Referring to Figure 2, in this embodiment, the bottom edge of the ring cover 18 is fixedly connected with an edge 19. The edge 19 covers the outside of the joint between the ring cover 18 and the port of the column tube 6, which can further improve the sealing performance of the ring cover 18.

[0043] Referring to Figures 1 and 4, the positioning mechanism 5 includes a first clamping member 51 and a second clamping member 52. The first clamping member 51 is fixedly installed on the frame 1, and the second clamping member 52 is slidably installed on the second clamping member 52. Both the first clamping member 51 and the second clamping member 52 are fixedly connected to an elastic positioning block 53 on the side of the column tube 6 of the chromatographic column, and a positioning port adapted to the column tube 6 of the chromatographic column is formed between the two elastic positioning blocks 53.

[0044] A guide rod 54 is fixedly connected to the second clamping member 52. A through hole for the guide rod 54 to pass through is provided on the first clamping member 51. A third spring 55 is coaxially sleeved on the guide rod 54. The third spring 55 abuts against the first clamping member 51 and the second clamping member 52.

[0045] A telescopic cylinder 56 is fixedly connected to the frame 1. The drive shaft end of the telescopic cylinder 56 is fixedly connected to the second clamping member 52. A start button 72 and a reset button 73 are fixedly installed on the mounting plate 7. The signal output ends of the start button 72 and the reset button 73 are connected to the signal input ends of the telescopic cylinder 56.

[0046] When the operator installs the bottom of the column tube 6 on the carrier 14, places the end of the column tube 6 on the outside of the outlet pipe 21, and covers the end of the column tube 6 with the ring cover 18, the operator can input a start signal through the start button 72. After receiving the start signal, the telescopic cylinder 56 drives the second clamping member 52 to move towards the first clamping member 51. The first clamping member 51 and the second clamping member 52 clamp and position the left and right sides of the column tube 6. The rubber positioning blocks on the first clamping member 51 and the second clamping member 52 can clamp the rubber positioning blocks between the two sides of the column tube 6 and the first clamping member 51 and the second clamping member 52, which can reduce the adverse effects of the clamping action of the first clamping member 51 and the second clamping member 52 on the column tube 6.

[0047] After the chromatographic packing material is filled, the operator can input a reset signal through the reset button 73. After receiving the reset signal, the telescopic cylinder 56 retracts the drive shaft so that the second clamping member 52 slides away from the first clamping member 51, making it easier for the operator to remove the column tube 6 from between the first clamping member 51 and the second clamping member 52.

[0048] Since a third spring 55 is provided between the first clamping member 51 and the second clamping member 52, the third spring 55 improves the stability of the sliding action of the second clamping member 52 as the second clamping member 52 approaches the first clamping member 51, and can accelerate the reset of the second clamping member 52 as the second clamping member 52 moves away from the first clamping member 51.

[0049] Referring to Figures 1 and 4, a mounting plate 7 is fixedly connected to the frame 1. A first clamping member 51 is fixedly installed on the mounting plate 7. An anti-detachment rail 71 is fixedly connected to the mounting plate 7. The anti-detachment rail 71 is arranged in an inverted trapezoidal shape. A limiting groove adapted to the rail is opened at the bottom of the second clamping member 52. The second clamping member 52 is slidably arranged on the anti-detachment rail.

[0050] By setting the anti-detachment rail 71 and the limiting slide groove, the technical effect of the second clamping member 52 sliding on the mounting plate 7 can be achieved, while reducing the occurrence of the second clamping member 52 falling off the mounting plate 7.

[0051] The implementation principle of the chromatographic packing device proposed in this application embodiment is as follows: When using a column packer to fill the chromatographic column with chromatographic packing material, the operator can pre-install the upper and lower ends of the column tube 6 on the elastic support mechanism, and then position the left and right sides of the column tube 6 through the positioning mechanism 5; during the process of the chromatographic packing material in the hopper 2 flowing into the column tube 6 of the chromatographic column through the discharge pipe 21, the operator is exempt from holding the column tube 6 by hand, which can effectively improve the convenience of the operator to use the packing device to fill the chromatographic packing material.

[0052] The above are all preferred embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A chromatographic packing device, comprising a frame (1), a hopper (2) mounted on the frame (1), a discharge pipe (21) connected to the bottom of the hopper (2), and a metering valve (3) mounted on the discharge pipe (21), characterized in that, The frame (1) is equipped with an elastic support mechanism and a positioning mechanism (5). The upper and lower ends of the column tube (6) of the chromatographic column are detachably installed between the elastic support mechanism and the discharge pipe (21). The positioning mechanism (5) is clamped and fixed on both sides of the column tube (6) of the chromatographic column.

2. The chromatographic packing device according to claim 1, characterized in that, The frame (1) includes a mounting base (11), on which a slot (12) is provided. The slot (12) is located directly below the discharge pipe (21). A first spring (13) is fixedly installed at the bottom of the slot (12). A carrier (14) is fixedly installed at the top of the first spring (13). A positioning groove (15) adapted to the bottom of the chromatographic column is provided at the top of the carrier (14). The carrier (14) is slidably disposed in the slot (12). An extension (16) is provided extending inward from the opening of the slot (12). The extension (16) is limited at the top of the carrier (14).

3. The chromatographic packing device according to claim 2, characterized in that, The frame (1) includes a top plate, through which a through hole is provided for the discharge pipe (21) to extend; a second spring (17) is fixedly connected to the top plate, the second spring (17) is coaxially sleeved on the outside of the discharge pipe (21), and a ring cover (18) is coaxially sleeved on the discharge pipe (21). The top of the ring cover (18) is fixedly connected to the bottom of the second spring (17), and the ring cover (18) abuts against the second spring (17) and the top of the column tube (6) of the chromatographic column.

4. A chromatographic packing device according to claim 3, characterized in that, The bottom edge of the ring cover (18) is fixedly connected with an edge (19).

5. A chromatographic packing device according to claim 4, characterized in that, The positioning mechanism (5) includes a first clamping member (51) and a second clamping member (52). The first clamping member (51) is fixedly mounted on the frame (1), and the second clamping member (52) is slidably mounted on the first clamping member (51). Both the first clamping member (51) and the second clamping member (52) have elastic positioning blocks (53) fixedly connected to the side of the column tube (6) of the chromatographic column. A positioning port adapted to the column tube (6) is formed between the two elastic positioning blocks (53). A guide rod (54) is fixedly connected to the second clamping member (52). The guide rod (54) is provided with a through hole for the guide rod (54) to pass through. A third spring (55) is coaxially sleeved on the guide rod (54). The third spring (55) is pressed between the first clamping member (51) and the second clamping member (52). A telescopic cylinder (56) is fixedly connected to the frame (1). The drive shaft end of the telescopic cylinder (56) is fixedly connected to the second clamping member (52). A start button (72) and a reset button (73) are fixedly installed on the mounting plate (7). The signal output ends of the start button (72) and the reset button (73) are connected to the signal input ends of the telescopic cylinder (56).

6. A chromatographic packing device according to claim 5, characterized in that, A mounting plate (7) is fixedly connected to the frame (1). The first clamping member (51) is fixedly installed on the mounting plate (7). An anti-detachment rail (71) is fixedly connected to the mounting plate (7). The anti-detachment rail (71) is arranged in an inverted trapezoidal shape. The bottom of the second clamping member (52) is provided with a limiting groove that matches the rail. The second clamping member (52) is slidably arranged on the anti-detachment rail.

Images