Parallel operation type continuous anesthesia device for large-scale animal experiments

Abstract

The utility model provides a parallel operation type continuous anesthesia device for mass animal experiments, which relates to the technical field of animal experiment instruments and comprises a box body, at least two through holes are arranged at the front end of the box body, and the through holes are hermetically connected with guide parts through mounting grooves. A variable-diameter contact piece is arranged at one end of the guide piece and used for tightly wrapping the neck of the animal; a guiding cavity and a guiding rope are arranged in an opening in the middle of the flexible cover, and the opening can be tightened by pulling the guiding rope to achieve sealing. By means of the design of'head and body separation ', the head of an experimental animal continuously inhales anesthetic gas in the box body, and limbs are led out of the box body for operation. By means of the structure, synchronous anesthesia and parallel limb operation of a plurality of animals are achieved, experiment efficiency is remarkably improved, anesthesia gas leakage is effectively blocked, continuity and stability of the anesthesia process are guaranteed, and animal stress response and personnel occupational exposure risks are reduced.

Description

Technical Field

[0001] This utility model relates to the field of animal experimental equipment technology, and in particular to a parallel operation continuous anesthesia device for large-scale animal experiments. Background Technology

[0002] In the fields of biopharmaceutical research and development and life science experiments, animal experiments are a crucial step in verifying the efficacy and safety of drugs. When performing experimental procedures such as injections, sampling, or surgery, general anesthesia is usually required to ensure the cooperation of the experimental animals and minimize their suffering. Currently, the industry primarily uses inhalation anesthesia for rodents (such as mice and rats). Common equipment falls into two categories: one is a fully enclosed, sealed anesthesia chamber, where multiple animals are anesthetized simultaneously within a sealed enclosure; the other is a single anesthesia mask, where medication is administered by covering the mouth and nose of a single animal. Both methods are widely used in existing laboratory environments, using anesthetic gases to induce anesthesia in animals and meet basic experimental anesthesia requirements.

[0003] However, the aforementioned existing technical solutions have significant limitations in practical large-scale animal experiments. While a single, sealed anesthesia box can accommodate multiple animals simultaneously, its completely enclosed structure necessitates removing the animal from the box when necessary for procedures such as injections or sampling. This interruption of anesthesia leads to rapid animal resuscitation, failing to meet the demands of prolonged anesthesia (e.g., exceeding 15 minutes) for limb manipulation. Furthermore, frequent removal and insertion increase animal stress. On the other hand, while a single anesthesia mask can maintain continuous anesthesia, its experimental efficiency is extremely low, making it unsuitable for parallel processing of multiple animals and failing to meet the demands of high-throughput experiments. Moreover, existing anesthesia boxes lack a dedicated sealing structure for limb removal; forced opening leads to significant anesthetic gas leakage, causing environmental pollution and safety hazards, and making it difficult to maintain a stable anesthetic concentration within the box. Utility Model Content

[0004] This invention provides a parallel-operation continuous anesthesia device for large-scale animal experiments, specifically comprising:

[0005] The enclosure has an input pipe and an output pipe on its left and right sides, respectively. A through-hole for inserting an animal is located at the front end of the enclosure. A mounting groove is formed around the through-hole, and a guide is mounted on the enclosure through the mounting groove. The guide is a frustum-shaped tubular structure with a flange on its outer side, and the guide is sealed to the mounting groove via the flange. A contact element, a ring-shaped structure with a variable inner diameter, is located on the inner wall of the opening at one end of the guide inside the enclosure. The other end of the guide is sealed to a ring-shaped connector. The connector has a flexible cover inside, with an opening in the middle. Inside the opening of the flexible cover is a guide cavity surrounding the opening, and a guide rope is inserted into the guide cavity. The two ends of the guide rope protrude from the guide cavity, and when the two ends of the guide rope move outwards, they pull the flexible cover, causing the opening in the middle of the flexible cover to close and seal. The enclosure has at least two through-holes.

[0006] Preferably, the flexible cover has a circular sealing element at the central opening; the outer side of the sealing element has a flexible pad made of elastic material; the outer periphery of the flexible pad has an annular groove, and the diameter of the groove of the flexible pad is equal to the thickness at the central opening of the flexible cover.

[0007] Preferably, the lower end of the guide member is provided with a guide groove, and the guide frame is connected to the sliding frame through the guide groove; the sliding frame and the guide groove are each provided with two through holes, and the through holes of the two correspond to each other, forming a set; a guide rod is inserted into one set of the through holes, the guide rod is fixedly connected to the guide groove, and the sliding frame slides along the guide rod; in the other set of the through holes, the through hole of the sliding frame is threaded, and a drive screw that penetrates the through hole of the guide groove is inserted; the drive screw is rotated to make the sliding frame slide along the guide groove; the upper end of the sliding frame is provided with a placement platform.

[0008] Preferably, the placement platform is provided with rotating flaps on both sides, and a locking device is provided between the flaps and the placement platform.

[0009] Preferably, the flap is provided with fasteners, and the number of fasteners is at least four.

[0010] Preferably, the front end of the housing is provided with a sliding groove, and the housing is connected to a baffle through the sliding groove; the baffle covers the front end of the guide.

[0011] Preferably, the front end of the guide member is provided with a sealing gasket that protrudes towards the baffle, and the sealing gasket abuts against the baffle.

[0012] Preferably, the box body is designed as an assembly structure composed of four plates; the left and right sides of the box body are provided with a first sealing cover and a second sealing cover; the first sealing cover and the second sealing cover are respectively provided with an input pipe and an output pipe.

[0013] Preferably, the left side of the box body has a connecting protrusion and the right side has a connecting groove; the first sealing cover has a connecting groove and is connected to the box body through the connecting protrusion; the second sealing cover has a connecting protrusion and is connected to the box body through the connecting groove, and all of the above connections are sealed connections.

[0014] Preferably, the multiple housings can be connected by their respective connecting protrusions and connecting grooves.

[0015] Beneficial effects

[0016] 1. In this utility model, at least two through holes and matching guide components are provided on the box body, breaking through the limitation of single-animal operation in traditional anesthesia equipment, realizing parallel anesthesia and synchronous operation of multiple experimental animals, and significantly improving the work efficiency of large-scale animal experiments. The device adopts the design concept of "head-body separation", using the contact components inside the guide component to tightly wrap the animal's neck, and combined with the sealing mechanism of the flexible cover and guide rope, effectively blocking the leakage of anesthetic gas from the limb outlet. While ensuring the stable concentration of anesthetic gas inside the box, it allows the experimenter to perform long-term fine operations on the animal's limbs outside the box without interrupting anesthesia, thereby ensuring the continuity and stability of the anesthesia depth during the experiment and reducing the stress response and gas leakage risk caused by frequent removal of animals;

[0017] 2. In this invention, the housing adopts a modular assembly structure, combined with a sliding frame, drive screw, and adjustable fasteners. This allows for flexible adjustment of the platform placement, animal posture, and limb fixation methods according to experimental needs, enabling wide adaptation to experimental animals of different sizes and species, greatly enhancing the versatility and practicality of the device. The connecting protrusions and grooves on the side walls of the housing not only achieve rapid sealing between the housing and the sealing cap but also support lateral splicing and expansion between multiple housing units. This meets the surge in anesthesia capacity requirements for ultra-large-scale experiments while facilitating thorough cleaning, disinfection, and component replacement after the experiment. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings of the embodiments will be briefly described below.

[0019] The accompanying drawings described below are only related to some embodiments of the present invention and are not intended to limit the scope of the present invention.

[0020] In the attached diagram:

[0021] Figure 1 A three-dimensional structural schematic diagram of a continuous anesthesia device for animal experiments according to an embodiment of the present invention is shown.

[0022] Figure 2 A three-dimensional cross-sectional schematic diagram of the guide of a continuous anesthesia device for animal experiments according to an embodiment of the present invention is shown.

[0023] Figure 3 An animal experiment continuous anesthesia device according to an embodiment of the present invention is shown. Figure 2 A magnified view of a portion of point A shown.

[0024] Figure 4 A three-dimensional structural schematic diagram of the sealing component of a continuous anesthesia device for animal experiments according to an embodiment of the present invention is shown.

[0025] Figure 5 A three-dimensional structural schematic diagram of the sliding frame of the continuous anesthesia device for animal experiments according to an embodiment of the present invention is shown.

[0026] Figure 6 An animal experiment continuous anesthesia device according to an embodiment of the present invention is shown. Figure 5 A schematic diagram of the three-dimensional structure at point B is shown.

[0027] Figure 7 An assembly diagram of the housing of a continuous anesthesia device for animal experiments according to an embodiment of the present invention is shown.

[0028] Figure 8 An animal experiment continuous anesthesia device according to an embodiment of the present invention is shown. Figure 7 A schematic diagram of the three-dimensional structure at point C is shown.

[0029] Figure 9 An assembly diagram of the baffle of a continuous anesthesia device for animal experiments according to an embodiment of the present invention is shown.

[0030] Figure 10 An animal experiment continuous anesthesia device according to an embodiment of the present invention is shown. Figure 9 A schematic diagram of the three-dimensional structure at point D is shown.

[0031] List of main reference numerals

[0032] 101. Housing; 102. Mounting slot; 103. Sliding slot; 104. Baffle;

[0033] 201. First sealing cap; 202. Second sealing cap;

[0034] 301. Guide component; 302. Sealing gasket; 303. Guide groove; 304. Contact component;

[0035] 401. Connector; 402. Flexible cover; 403. Guide cavity; 404. Guide rope;

[0036] 501. Sliding frame; 502. Drive screw; 503. Placement platform; 504. Flip plate; 505. Fixing component; 506. Locking component;

[0037] 601. Sealing component; 602. Flexible pad. Detailed Implementation

[0038] To make the objectives, technical solutions, and advantages of this application clearer, the technical solutions of this application will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0039] In this document, “illustrative” means “serving as an example, illustration or description”, and any illustration or implementation described herein as “illustrative” should not be construed as a more preferred or advantageous technical solution.

[0040] To keep the drawings concise, only the parts relevant to this application are shown schematically in each drawing, and they do not represent the actual structure of the product. In addition, to make the drawings concise and easy to understand, in some drawings, only one of the components with the same structure or function is shown schematically, or only one of them is labeled.

[0041] In this document, unless otherwise expressly specified and limited, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance; unless otherwise specified or explained, the term "multiple" refers to two or more; the terms "connected," "fixed," etc., should be interpreted broadly. For example, "connected" can be a fixed connection, a detachable connection, an integral connection, or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0042] Example: Please refer to Figures 1 to 10 :

[0043] This invention proposes a parallel-operation continuous anesthesia device for large-scale animal experiments, comprising:

[0044] The enclosure 101 has an input pipe and an output pipe on its left and right sides, respectively. A through-hole for inserting an animal is located at the front of the enclosure 101. A mounting groove 102 is formed around the through-hole, and a guide member 301 is mounted on the enclosure 101 through the mounting groove 102. The guide member 301 is a frustum-shaped tubular structure with a flange on its outer side, and is sealed to the mounting groove 102 via the flange. A contact member 304, which is an annular shape with a variable inner diameter, is located on the inner wall of the opening at one end of the guide member 301 inside the enclosure 101. Structure: The other end of the guide 301 is sealed with an annular connector 401. The connector 401 has a flexible cover 402 inside. The flexible cover 402 has an opening in the middle. The opening in the middle of the flexible cover 402 has a guide cavity 403 surrounding the opening in the middle of the flexible cover 402. A guide rope 404 is inserted into the guide cavity 403. The two ends of the guide rope 404 protrude from the guide cavity 403. When the two ends of the guide rope 404 move outward, they will pull the flexible cover 402, so that the opening in the middle of the flexible cover 402 is closed and sealed. The housing 101 has at least two through holes.

[0045] like Figure 1 and Figure 2 As shown, in this embodiment, the anesthetic gas circulates inside the chamber 101 through the input and output pipes, maintaining the concentration of anesthetic gas inside the chamber 101 and carrying away the waste gas produced by the experimental animals. The head of the experimental animal passes through the guide 301 and enters the chamber 101 for anesthesia. During this process, the neck of the experimental animal is placed inside the contact 304. At the same time, the contact 304 can tightly wrap the neck of the experimental animal by changing its inner diameter, preventing the anesthetic gas from leaking out. The flexible cover 402 can be made of an airtight material, such as meltblown cloth or flexible plastic film. When its opening is tightened by the guide rope 404, it prevents a large amount of anesthetic gas from leaking out of its opening, thereby ensuring the safety of the laboratory environment. When the animal experiment begins, its opening can be quickly opened by the experimenter.

[0046] In the above embodiment, the box 101 is configured with multiple through holes, and then an animal entrance consisting of multiple guides 301 and flexible cover 402 is installed. This can meet the needs of multiple groups of animals to conduct parallel experiments at the same time, which greatly improves the experimental efficiency. Moreover, multiple groups of animals are in the same anesthesia environment at the same time, which can effectively maintain the variable of the experimental animal anesthesia environment.

[0047] It should be noted that the contact 304 can achieve passive diameter change through its own elasticity. For example, if the contact 304 is made of elastic material, it will automatically fit when the head of the experimental animal passes through. It can also achieve active diameter change through external control. For example, if an air bladder is used, the air bladder can be controlled to expand and fit the animal's neck when the head of the experimental animal passes through.

[0048] It should be noted that the elasticity of the material used in the flexible cover 402 is not limited, meaning that the flexible cover 402 can tend to return to the open state under the action of elasticity, and can also be opened completely by hand.

[0049] The flexible cover 402 has a circular sealing element 601 at the central opening; the sealing element 601 has a flexible pad 602 made of elastic material on its outer side; the flexible pad 602 has an annular groove on its outer periphery, and the diameter of the groove of the flexible pad 602 is equal to the thickness at the central opening of the flexible cover 402.

[0050] like Figure 2 , Figure 3 and Figure 4 As shown, in this embodiment, after the opening in the middle of the flexible cover 402 is tightened, the outer edge of the opening in the middle fits tightly with the groove of the flexible pad 602, further ensuring the airtightness of the flexible cover 402 and preventing the leakage of anesthetic gas. In order to ensure ease of use, the sealing member 601 can be partially connected to the flexible cover 402 at the edge, so that the sealing member 601 does not detach from the flexible cover 402 after the opening in the middle of the flexible cover 402 is opened. The preferred connection position is located at the upper edge. When located here, when the experimental animal is anesthetized, the sealing member 601 is placed at the neck and back of the experimental animal and can be adjusted by the staff to minimize the impact of the sealing member 601 on the experiment.

[0051] The guide member 301 has a guide groove 303 at its lower end, and the guide member 301 is connected to the sliding frame 501 through the guide groove 303. The sliding frame 501 and the guide groove 303 each have two through holes, and the through holes correspond to each other, forming a set. A guide rod is inserted into one set of through holes, and the guide rod is fixedly connected to the guide groove 303, and the sliding frame 501 slides along the guide rod. In the other set of through holes, the sliding frame 501 has a thread inside, and a drive screw 502 that penetrates the through hole of the guide groove 303 is inserted. The drive screw 502 is rotated to make the sliding frame 501 slide along the guide groove 303. The upper end of the sliding frame 501 has a placement platform 503.

[0052] like Figure 5 and Figure 6 As shown, in this embodiment, the position of the placement platform 503 can be precisely adjusted through the cooperation of the guide groove 303, the sliding frame 501, and the drive screw 502, enabling the device to adapt to experimental animals of different sizes, such as mice and rats, or different neck lengths, ensuring that the animal's neck is accurately positioned in the sealing position of the contact element. In addition, the placement platform 503 provides a stable support surface for the animal's limbs extending out of the box, preventing the animal's limbs from dangling and swaying, providing a stable physical basis for researchers to perform delicate operations such as tail vein injection, and improving the success rate of experimental operations.

[0053] The placement platform 503 has rotating flaps 504 on both sides, and a locking element 506 is provided between the flaps 504 and the placement platform 503.

[0054] like Figure 6 As shown, in this embodiment, the posture of the experimental animal can be adjusted by the flap 504. For example, when the flap 504 is parallel to the placement platform 503, the experimental animal lies on the placement platform. When the flap 504 is perpendicular to the placement platform 503, the experimental animal's limbs can hang down naturally. Through the above structure, the posture adjustment needs of the experimental animal can be fully met. The locking member 506 acts as a damper to fix the relative position of the flap 504 and the placement platform 503, making the angle adjustment of the flap 504 and the placement platform 503 more flexible.

[0055] Among them, the flap 504 is provided with a fastener 505, and the number of fasteners 505 is at least four.

[0056] like Figure 6 As shown, in this embodiment, the limbs of the experimental animal can be fixed by the fixing member 505. Generally, four fixing members 505 are used to fix the limbs of the experimental animal. If necessary, a fifth fixing member 505 can be set on the placement platform 503 to fix the tail of the experimental animal.

[0057] In addition, the fixture 505 is detachable and can be slidably adjusted from the flip plate 504 and the placement platform 503, so that the fixture 505 can be adjusted according to the body size of the experimental animal.

[0058] Specifically, fastener 505 is a strap with a locking mechanism.

[0059] The front end of the housing 101 is provided with a sliding groove 103, and the housing 101 is connected to a baffle 104 through the sliding groove 103; the baffle 104 covers the front end of the guide member 301.

[0060] like Figure 9 and Figure 10 As shown, in this embodiment, when the experiment is not being conducted, the baffle 104 covers the front end of the guide 301 to block and protect the guide 301. At the same time, when the number of experimental animals is less than the maximum number of boxes 101 that can be used, only the corresponding number of through holes in the boxes 101 can be opened.

[0061] The guide member 301 has a sealing gasket 302 protruding towards the baffle 104 at its front end, and the sealing gasket 302 abuts against the baffle 104.

[0062] like Figure 1As shown, in this embodiment, when the baffle 104 is closed, the sealing gasket 302 abuts tightly against the baffle 104, ensuring that the anesthetic gas inside the box 101 will not leak through the closed channel gap when the channel is closed, thus maintaining the positive pressure environment and anesthetic concentration inside the box 101.

[0063] The housing 101 is designed as an assembly structure composed of four plates; the left and right sides of the housing 101 are provided with a first sealing cover 201 and a second sealing cover 202; the first sealing cover 201 and the second sealing cover 202 are respectively provided with an input pipe and an output pipe.

[0064] like Figure 7 and Figure 8 As shown, in this embodiment, the combination of the first sealing cap 201 and the second sealing cap 202 allows the entire device to be quickly disassembled and assembled, which is crucial for thorough cleaning, disinfection, and replacement of damaged parts after animal experiments.

[0065] The box body 101 has a connecting protrusion on the left side and a connecting groove on the right side; the first sealing cover 201 has a connecting groove and is connected to the box body 101 through the connecting protrusion of the box body 101; the second sealing cover 202 has a connecting protrusion and is connected to the box body 101 through the connecting groove of the box body 101. All of the above connections are sealed connections.

[0066] like Figure 8 and Figure 9 As shown in this embodiment, the mortise and tenon interlocking structure not only provides a firm connection but also ensures the sealing of the connection, preventing anesthetic gas from escaping from the splice seam on the side of the box 101.

[0067] The multiple housings 101 can be connected by their respective connecting protrusions and connecting grooves.

[0068] In this embodiment, multiple boxes 101 can be directly connected to each other by using the connecting protrusions and grooves on the side wall of the box 101, giving the device strong expandability. When the number of experimental animals increases dramatically, there is no need to replace the new equipment. Just splice together multiple box 101 units to instantly expand the capacity of the anesthesia device and meet the needs of ultra-large-scale experiments.

[0069] The above description is merely a specific embodiment of this application. Under the guidance of the above teachings, those skilled in the art can make other improvements or modifications based on the above embodiments. Those skilled in the art should understand that the above specific description is only to better explain the purpose of this application, and the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A parallel-operation continuous anesthesia device for large-scale animal experiments, comprising: The box (101) has an input pipe and an output pipe on its left and right sides, respectively, and a through hole for animals to be placed in the front end of the box (101). The box (101) is characterized by having an installation groove (102) around the through hole, and a guide (301) is installed on the box (101) through the installation groove (102). The guide (301) is a frustum-shaped tubular structure, and a flange is provided on the outer side of the guide (301), and the guide (301) is sealed to the installation groove (102) through the flange. A contact (304) is provided on the inner wall of the opening at one end of the guide (301) inside the box (101). The component (304) is a ring structure with a variable inner diameter; the other end of the guide component (301) is sealed to a ring-shaped connector (401), the connector (401) is provided with a flexible cover (402) inside, the flexible cover (402) has an opening in the middle, and the opening in the middle of the flexible cover (402) is provided with a guide cavity (403) surrounding the opening in the middle of the flexible cover (402), and a guide rope (404) is inserted into the guide cavity (403); the two ends of the guide rope (404) protrude from the guide cavity (403), and when the two ends of the guide rope (404) move outward, they will pull the flexible cover (402) to close and seal the opening in the middle of the flexible cover (402); The housing (101) has at least two through holes.

2. The parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 1, characterized in that, The flexible cover (402) has a circular sealing element (601) at the central opening; the sealing element (601) has a flexible pad (602) made of elastic material on its outer side; the flexible pad (602) has an annular groove on its outer periphery, and the diameter of the groove of the flexible pad (602) is equal to the thickness at the central opening of the flexible cover (402).

3. The parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 1, characterized in that, The lower end of the guide member (301) is provided with a guide groove (303), and the guide member (301) is connected to the sliding frame (501) through the guide groove (303); the sliding frame (501) and the guide groove (303) are each provided with two through holes, and the through holes of the two correspond to each other, and the corresponding through holes form a set; a guide rod is inserted into one set of the through holes, the guide rod is fixedly connected to the guide groove (303), and the sliding frame (501) slides along the guide rod; in the other set of the through holes, the through hole of the sliding frame (501) is provided with a thread, and a drive screw (502) that penetrates the through hole of the guide groove (303) is inserted; the drive screw (502) is rotated to make the sliding frame (501) slide along the guide groove (303); the upper end of the sliding frame (501) is provided with a placement platform (503).

4. A parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 3, characterized in that, The placement platform (503) is provided with rotating flaps (504) on both sides, and a locking element (506) is provided between the flaps (504) and the placement platform (503).

5. A parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 4, characterized in that, The flap (504) is provided with a fixing member (505), and the number of fixing members (505) is at least four.

6. A parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 1, characterized in that, The front end of the housing (101) is provided with a sliding groove (103), and the housing (101) is connected to a baffle (104) through the sliding groove (103); the baffle (104) covers the front end of the guide (301).

7. A parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 6, characterized in that, The guide member (301) has a sealing gasket (302) protruding towards the baffle (104) at its front end, and the sealing gasket (302) abuts against the baffle (104).

8. A parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 1, characterized in that, The box body (101) is designed as an assembly structure composed of four plates; the left and right sides of the box body (101) are provided with a first sealing cover (201) and a second sealing cover (202); the first sealing cover (201) and the second sealing cover (202) are respectively provided with an input pipe and an output pipe.

9. A parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 8, characterized in that, The box body (101) has a connecting protrusion on the left side and a connecting groove on the right side; the first sealing cover (201) has a connecting groove and is connected to the box body (101) through the connecting protrusion of the box body (101); the second sealing cover (202) has a connecting protrusion and is connected to the box body (101) through the connecting groove of the box body (101). All of the above connections are sealed connections.

10. A parallel-operation continuous anesthesia device for large-scale animal experiments according to claim 9, characterized in that, The multiple housings (101) can be connected by their respective connecting protrusions and connecting grooves.

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