Liquid injector and density gradient system preparation device
By designing the outflow section and outlet structure of the injector and combining it with the drive device, the problems of solution mixing and density gradient disorder during liquid addition were solved, and a more stable density gradient system was constructed.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- GUANGZHOU NAT LAB
- Filing Date
- 2025-05-29
- Publication Date
- 2026-05-12
AI Technical Summary
Existing injectors can easily cause mixing and density gradient disturbances in the already injected solution when adding liquid, affecting the effectiveness of density gradient centrifugation technology.
Design a liquid injector that allows the liquid to spread evenly along the outflow section by setting a bearing surface and an outlet structure in the outflow section, avoiding direct impact on the injected liquid layer, and achieves directional addition of liquid through a driving device.
It effectively reduces the impact of liquid on the injected liquid, improves the stability and uniformity of the density gradient, and increases the success rate of constructing the density gradient system.
Smart Images
Figure CN224221380U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of biotechnology, and in particular to a liquid injector and a density gradient system preparation device. Background Technology
[0002] Density gradient centrifugation utilizes a liquid to create a continuous or discontinuous density gradient system within a centrifuge tube. Cell suspensions or tissue homogenates are placed on top of this gradient, and the separation of cells, organelles, or particles is achieved under the influence of gravity or centrifugal force. The key to density gradient centrifugation is the stable loading of liquids of different densities into the centrifuge tube and the creation of clear boundaries. Specifically, liquids can be added sequentially from highest to lowest density or vice versa. Related techniques employ injectors for liquid addition. These injectors guide the liquid towards the tube wall, buffering it and allowing it to flow downwards. However, this method still allows later-added liquids to impact the already injected liquid layer, potentially causing problems such as solution mixing and density gradient disruption. Utility Model Content
[0003] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes a liquid injector that can reduce the impact of subsequently injected liquid on already injected liquid, and improve problems such as solution mixing and density gradient disorder.
[0004] This invention also proposes a device for preparing a density gradient system.
[0005] According to the first embodiment of the present invention, the liquid injector is used to inject liquid into a sample container in a set liquid injection posture. The liquid injector includes a liquid injection tube, which has an inlet for liquid inflow and an outlet for liquid outflow.
[0006] The injection tube includes an outflow section with an outlet. When the injector is in the injection posture, the inner wall of the outflow section includes a bearing surface at the bottom of the inner wall. The bearing surface is continuously arranged and extends to the farthest end of the outflow section. The outlet is configured to allow liquid to flow out as it flows along the outflow section.
[0007] The injector according to the embodiments of the present invention has at least the following beneficial effects:
[0008] This embodiment prevents the liquid from flowing directly downwards from the bottom of the outflow section before it exits, thus avoiding direct impact of the liquid on the already injected liquid layer. Furthermore, the outlet is configured to allow liquid to flow out as it travels along the outflow section. Compared to conventional pipes that only open at the distal end, this embodiment allows for relatively uniform liquid diffusion, preventing liquid accumulation at the distal end and its intrusion into the already injected liquid layer.
[0009] In other embodiments of the present invention, the outlet extends along the length direction of the outflow section, and the outlet has a first end along the length direction, the first end extending to the farthest end of the outflow section.
[0010] In other embodiments of this utility model, the first end extends to the bearing surface.
[0011] In other embodiments of the present invention, the outlet further has a second end along the length direction, wherein the distance between the bearing surface and the outlet gradually decreases along the direction from the second end to the first end.
[0012] In other embodiments of this utility model, the distal end face of the outflow section is closed.
[0013] In other embodiments of this utility model, the outlet extends along the length direction of the outflow section, or the outlet is provided in multiple ways, and the multiple outlets are spaced apart along the length direction of the outflow section.
[0014] In other embodiments of this utility model, the injection tube further includes an inflow section, one end of which is connected to the outflow section, the other end of which is provided with the inlet, and the axis of the inflow section intersects with the axis of the outflow section.
[0015] In other embodiments of this utility model, the axis of the inflow section is perpendicular to the axis of the outflow section.
[0016] In other embodiments of this utility model, the injector further includes an inlet tube connected to the injection tube, the two ends of the inlet tube having an injection port and an outlet respectively, the outlet communicating with the inlet of the inflow section, and the cross-sectional area of the injection port being larger than the cross-sectional area of the inlet.
[0017] In other embodiments of this utility model, the inner wall surface of the outflow section is configured as an arc-shaped wall surface.
[0018] The density gradient system preparation apparatus according to the second embodiment of this utility model includes:
[0019] The aforementioned injector;
[0020] A support base for holding sample containers;
[0021] The mounting bracket is connected to the support seat and is used to mount the injector in the injection posture.
[0022] In other embodiments of this utility model, the density gradient system preparation apparatus further includes a driving device, the support base is connected to at least one of the driving devices in the mounting frame, and the driving device is configured to drive relative movement between the support base and the mounting frame, the relative movement having at least a vertical component.
[0023] In other embodiments of this utility model, the mounting bracket includes a mounting plate having a first placement hole, and the injector further includes a mounting flange connected to the injector tube, the injector tube passing through the first placement hole, and the mounting flange abutting against the mounting plate to suspend the injector on the mounting plate.
[0024] In other embodiments of this utility model, the support base has a second placement hole for placing the sample container;
[0025] Alternatively, the density gradient system preparation apparatus may further include a support component having a second placement hole for placing the sample container, the support component being placed on the support seat and capable of moving relative to the support seat to detach from the support seat.
[0026] In other embodiments of this utility model, the axis of the second placement hole is arranged in the vertical direction, and when the injector is in the set posture, the axis of the outflow section is parallel to the horizontal direction.
[0027] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description
[0028] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein:
[0029] Figure 1 This is a three-dimensional schematic diagram of the injector in an embodiment of the present invention;
[0030] Figure 2 for Figure 1 A cross-sectional view of the outflow section of the injector;
[0031] Figure 3 for Figure 1 Side view of the injection device;
[0032] Figure 4This is a cross-sectional view of another embodiment of the injector in this utility model;
[0033] Figure 5 This is a cross-sectional view of another embodiment of the injector in this utility model;
[0034] Figure 6 This is a cross-sectional view of another embodiment of the injector in this utility model;
[0035] Figure 7 This is a cross-sectional view of another embodiment of the injector in this utility model;
[0036] Figure 8 This is a cross-sectional view of another embodiment of the injector in this utility model;
[0037] Figure 9 This is a cross-sectional view of another embodiment of the injector in this utility model;
[0038] Figure 10 This is a schematic diagram of the density gradient system preparation device in an embodiment of the present invention;
[0039] Figure 11 This is a schematic diagram of the process for constructing a density gradient system in an embodiment of this utility model.
[0040] Figure label:
[0041] Density gradient system preparation apparatus 10;
[0042] Sample container 20;
[0043] First layer of liquid 30;
[0044] The second layer of liquid is 40;
[0045] Injector 100, injection tube 110, outflow section 111, inner wall surface 111a, bearing surface 111b, farthest end of outflow section 111c, highest part of outflow section 111d, inflow section 112, inlet tube 120, mounting flange 130, inlet 101, outlet 102, first end 102a, second end 102b, injection port 103, outlet 104;
[0046] Support 200;
[0047] Mounting bracket 300, mounting plate 310;
[0048] Drive device 400, connecting rod 410, adjusting mechanism 420, connecting rod 430;
[0049] 500 load-bearing components. Detailed Implementation
[0050] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.
[0051] In the description of this utility model, it should be understood that the directional descriptions, such as up, down, front, back, left, right, etc., indicate the directional or positional relationship based on the directional or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0052] In the description of this utility model, "several" means one or more, "multiple" means two or more, "greater than," "less than," and "exceeding" are understood to exclude the stated number, while "above," "below," and "within" are understood to include the stated number. The use of "first" and "second" in the description is merely for distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features, or implicitly indicating the order of the indicated technical features.
[0053] In the description of this utility model, unless otherwise explicitly defined, terms such as "setting," "installation," and "connection" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this utility model in conjunction with the specific content of the technical solution.
[0054] In the description of this utility model, the terms "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of this utility model. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0055] As mentioned earlier, current injectors used for constructing density gradient systems typically employ a wall-mounted injection method. However, this method still causes the liquid to flow downwards, resulting in a significant impact on other injected liquids and leading to problems such as solution mixing and density gradient disruption. Therefore, this invention proposes an injector 100 that reduces the impact of subsequently injected liquids on already injected liquids, thereby improving the success rate of constructing density gradient systems.
[0056] Reference Figure 1This diagram shows a perspective view of the injector 100 in the first embodiment of the present invention. The injector 100 is used to inject liquid into the sample container 20 in a predetermined injection posture. That is, the injector 100 in this embodiment needs to be used in a specific posture. The injector 100 can be held in the injection posture by an auxiliary mechanism such as the mounting bracket 300 in the subsequent density gradient system preparation device 10. The sample container 20 can be a tube capable of containing liquid, such as a centrifuge tube.
[0057] The liquid injector 100 includes a liquid injection tube 110, which has an inlet 101 for liquid inflow and an outlet 102 for liquid outflow. Liquid can flow into the liquid injection tube 110 through the inlet 101 and flow out into a sample container through the outlet 102. Exemplarily, the inlet 101 and the outlet 102 are located at opposite ends of the liquid injection tube 110. In some embodiments, the user can directly inject liquid into the liquid injection tube 110 through the inlet 101. In other embodiments, the user injects liquid through other structures, and the injected liquid is guided into the liquid injection tube 110 through other structures.
[0058] The injection tube 110 includes an outflow section 111, which is provided with the aforementioned outlet 102. The outflow section 111 extends into the sample container during injection. When the injector 100 is in, for example... Figure 1 When the liquid injection posture is as shown, the outflow section 111 is parallel to the surface of the injected liquid, as shown in the reference. Figure 2 , Figure 3 The inner wall surface 111a of the outflow section 111 includes a bearing surface 111b, which is located at the lowest point of the entire inner wall surface 111a. This bearing surface 111b is continuously arranged, meaning the bottom of the inner wall surface 111a is a continuous solid structure. Furthermore, the inner wall surface 111a extends to the farthest end 111c of the outflow section 111. This prevents liquid from flowing directly downwards from the bottom of the outflow section 111 before exiting, thus avoiding direct downward impact on the already injected liquid layer. On the other hand, the outlet 102 is configured to allow liquid to flow out during its flow along the outflow section 111. Compared to conventional pipes that only open at the distal end, in this embodiment, the liquid can diffuse relatively uniformly, preventing liquid accumulation at the distal end and intrusion into the already injected liquid layer.
[0059] It should be noted that this embodiment does not limit the specific size or shape of the bearing surface 111b, as long as the lowest point of the bearing surface 111b is the lowest point of the entire inner wall surface 111a, and the bearing surface 111b is continuous and extends a certain length along the cross-sectional direction, thereby preventing the liquid from flowing directly downwards. Figure 3 The dashed lines in the figure roughly indicate the approximate range of the bearing surface 111b in the embodiment, but it can be increased or decreased based on this.
[0060] It should also be noted that "the liquid flows out during the flow along the outflow section 111" specifically means that the liquid can flow out from the outflow section 111 at other parts before reaching the farthest end 111c, rather than only flowing out from the farthest end 111c.
[0061] It should also be noted that the farthest end 111c of the outflow section 111 refers to the part that extends furthest along the flow direction. Figure 2 As shown in the example, when the outflow section 111 has a slanted surface, the farthest end 111c of the outflow section 111 specifically refers to the lowest part of the far end face of the outflow section 111.
[0062] Based on the first embodiment, in some embodiments of this utility model, reference is made to Figure 2 The outlet 102 extends along the length of the outflow section 111. The outlet 102 has a first end 102a along the length, which extends to the farthest end 111c of the outflow section 111. That is, in this embodiment, the liquid can also flow out from the farthest end 111c of the outflow section 111, thereby further increasing the diffusion range of the liquid and making the liquid distribution more uniform.
[0063] When the first end 102a extends to the farthest end 111c of the outflow section 111, in some embodiments of this utility model, refer to Figure 2 The first end 102a also extends to the bearing surface 111b of the inner wall surface 111a, that is, to the lowest position of the inner wall surface 111a. At this time, the liquid can flow out from the farthest end 111c along the extension direction of the bearing surface 111b. When the outflow section 111 is parallel to the liquid surface of the lower liquid and contacts the liquid surface of the lower liquid, the liquid flowing out from the farthest end 111c is also roughly parallel to the liquid surface, which helps to form a new layer.
[0064] In other embodiments, the outlet 102 may not extend to the bearing surface 111b of the inner wall surface 111a, see reference. Figure 5 The outlet 102 is higher than the bearing surface 111b.
[0065] When the first end 102a extends to the farthest end 111c of the outflow section 111, in some embodiments of this utility model, refer to Figure 2 , Figure 4 The outlet 102 also has a second end 102b along its length, and along the direction from the second end 102b to the first end 102a, that is... Figure 2 , Figure 4From left to right, the distance between the outlet 102 and the bearing surface 111b gradually decreases. For example, the far end surface where the outlet 102 is located is formed as an inclined surface. In this way, the outlet 102 in this embodiment can be formed by cutting off part of the structure in a conventional pipeline, which helps to reduce the manufacturing cost.
[0066] In other embodiments, reference is made to Figure 6 The distance between the outlet 102 and the bearing surface 111b can also remain constant.
[0067] Based on the first embodiment, in some other embodiments of the present invention, reference is made to... Figure 7 The distal end face of the outflow section 111 is closed, so that liquid can only flow out circumferentially from the outflow section 111 and cannot flow out from the distal end face. In this case, the outlet 102 is entirely located on the outer circumferential surface of the outflow section 111. It should be noted that the outlet 102 in this embodiment can be as follows: Figure 7 As shown, the highest part 111d extending to the outflow section can also be as follows: Figure 8 The highest part 111d shown is not penetrated to the outflow section.
[0068] When the distal end face of the outflow section 111 is closed, in some embodiments of this utility model, refer to Figure 7 , Figure 8 The outlet 102 extends along the length of the outflow section 111. The distance between the outlet 102 and the bearing surface 111b can be constant or gradually decrease along the direction of liquid flow.
[0069] In other embodiments, reference is made to Figure 9 Multiple outlets 102 are provided, and the multiple outlets 102 are spaced apart along the length of the outflow section 111. At this time, the shape of the outlet 102 can be circular, rectangular, etc.
[0070] Based on the first embodiment, in some other embodiments of this utility model, reference is made to... Figure 1 The injection tube 110 also includes an inflow section 112, one end of which is connected to the outflow section 111, and the other end of which has an inlet 101. The axis of the inflow section 112 intersects the axis of the outflow section 111. Thus, when the injector 100 is in an injection posture such that the outflow section 111 is parallel to the surface of the injected liquid, the inlet 101 can be positioned upwards, facilitating liquid injection by the user. For example, the inflow section 112 and the outflow section 111 are connected as a single unit.
[0071] In some further embodiments, the axis of the inflow section 112 is perpendicular to the axis of the outflow section 111. Thus, when the injector 100 is in the injection posture such that the outflow section 111 is parallel to the surface of the injected liquid, the inlet 101 can be set vertically upward, making it convenient for the user to inject liquid.
[0072] When the injection tube 110 also includes an inflow section 112, refer to Figure 1 The injector 100 also includes an inlet tube 120 connected to the injection tube 110. The inlet tube 120 has an injection port 103 and an outlet 104 at its two ends. The outlet 104 is connected to the inlet 101 of the inflow section 112. The cross-sectional area of the injection port 103 is larger than that of the inlet 101, allowing the user to inject liquid through the larger cross-sectional area of the injection port 103, thus reducing the difficulty of injection. For example, the main body of the inlet tube 120 is constructed as a cylinder, with a tapered hemispherical bottom connected to the lower part of the cylinder. The top of the cylinder has an injection port 103, and the hemispherical bottom has an outlet 104.
[0073] Based on the first embodiment, in some other embodiments of this utility model, reference is made to... Figure 3 The inner wall surface 111a of the outflow section 111 is set as an arc-shaped wall surface, specifically a circular arc wall surface, that is, the injection pipe 110 is set as a circular pipe, which is convenient for processing.
[0074] The second embodiment of this utility model proposes a density gradient system preparation device 10, referring to... Figure 10 The density gradient system preparation device 10 includes a support 200, a mounting frame 300, and the injector 100 in the aforementioned embodiment. The support 200 is used to support the sample container 20, and the mounting frame 300 is used to install the injector 100 in an injection posture, thereby achieving relative fixation between the injector 100 and the sample container 20.
[0075] As shown in the figure, the support 200 is located below the mounting frame 300, and the two are connected by side plates. The support 200, the mounting frame 300 and each side plate can define the working space, and the sample container 20 can be placed in the working space to isolate the external environment.
[0076] For example, the support 200 can support multiple sample containers 20, and the mounting bracket 300 can mount multiple injectors 100, the number of injectors 100 being equal to the number of sample containers 20, and their positions being set accordingly.
[0077] Based on the second embodiment, in some embodiments of this utility model, reference is made to Figure 10The density gradient system preparation apparatus 10 further includes a driving device 400. At least one driving device 400 is connected to the support 200 and the mounting frame 300. The driving device 400 is configured to drive relative motion between the support 200 and the mounting frame 300, the relative motion having at least a vertical component. Specifically, referring to… Figure 11 In the initial state, the distance between the support 200 and the mounting frame 300 is relatively large, which facilitates the injection or discharge of the sample container 20. When the preparation begins, the support 200 and the mounting frame 300 move relative to each other so that the outflow section 111 of the injection tube 110 enters the bottom of the sample container 20 to add the first layer of liquid 30. After the first layer of liquid 30 is added and a stable liquid layer is formed, the support 200 and the mounting frame 300 move relative to each other again so that the injector 100 is lifted relative to the sample container 20 until the bottom of the outflow section 111 contacts the liquid surface of the first layer of liquid 30. Then the second layer of liquid 40 is added. This cycle is repeated to construct the density gradient system.
[0078] It should be noted that "relative movement between the support 200 and the mounting frame 300" can mean that the support 200 is stationary while the mounting frame 300 is moving, or that the mounting frame 300 is stationary while the support 200 is moving, or that both the support 200 and the mounting frame 300 can move.
[0079] It should also be noted that the aforementioned "relative motion has at least a vertical component" includes both vertical relative motion and relative motion in an inclined direction. For the former, the sample container 20 can be placed vertically, and for the latter, the sample container 20 can be placed at an incline.
[0080] Taking the vertical movement of the support seat 200 as an example, the driving device 400 can be a scissor support device. One end of the scissor support device is connected to the support seat 200, and the other end is connected to the base below the support seat 200. For example, it includes multiple sets of connecting rods 410. Taking one set of connecting rods 410 as an example, one set of connecting rods 410 includes multiple pairs of cross-arranged connecting rods 410. The cross-sections are rotatably connected, and adjacent pairs of connecting rods 410 are also rotatably connected. As the connecting rods 410 rotate, the entire scissor support device will drive the support seat 200 to move in the vertical direction. The scissor bracing device also includes an adjusting mechanism 420 and connecting rods 430. The connecting rods 430 are connected between two adjacent sets of connecting rods 410. Specifically, one end of the connecting rod 430 is connected to the rotating connection part of two adjacent pairs of connecting rods 410 in one set, and the other end is connected to the rotating connection part of two adjacent pairs of connecting rods 410 in the other set, enabling the various connecting rods 410 to move synchronously. Two connecting rods 430 are provided, and the adjusting mechanism 420 is connected to each of the two connecting rods 430, driving the two connecting rods 430 to move relative to or in opposite directions, thereby driving each connecting rod 410 to rotate. The adjusting mechanism 420 can be a threaded fastener, threadedly connected to each of the two connecting rods 430. The adjusting mechanism 420 can be driven by the user or by a power device such as a motor.
[0081] The drive device 400 can also be a lead screw drive device, which includes a lead screw and a lead screw seat. The lead screw is vertically arranged, and its two ends are rotatably connected to fixed seats (not shown). The lead screw seat is threadedly connected to the lead screw and fixedly connected to the bearing seat 200. As the lead screw rotates, the lead screw seat can drive the bearing seat 200 to move in the vertical direction. The lead screw can be driven by the user or by a power device such as a motor.
[0082] The drive device 400 can also be a gear-rack drive device, which includes a gear and a rack. The rack is vertically arranged and meshes with the gear. The rack is fixedly connected to the support seat 200. As the gear rotates, the rack can drive the support seat 200 to move in the vertical direction. The gear can be driven by the user or by a power device such as a motor.
[0083] Based on the second embodiment, in some embodiments of this utility model, reference is made to Figure 10 The mounting bracket 300 includes a mounting plate 310, which has a first placement hole. The shape of the first placement hole is adapted to the corresponding structure of the injector 100. For example, when the injector 100 is a rotating body that passes through the first placement hole, the first placement hole is set to be circular.
[0084] Reference Figure 1The injector 100 also includes a mounting flange 130 connected to the injection tube 110. When the injection tube 110 passes through the first placement hole, the mounting flange 130 abuts against the mounting plate 310, so that the injector 100 is suspended from the mounting plate 310. For example, when the injector 100 includes an inlet tube 120, the mounting flange 130 is connected to the inlet tube 120, specifically to its top. When the injector 100 does not include the inlet tube 120, the mounting flange 130 is connected to the inflow section 112, specifically to its top. When the outflow section 111 and the inflow section 112 of the injector 100 are perpendicular to each other, and the sample container 20 is placed vertically, the abutment of the mounting flange 130 against the mounting plate 310 allows the outflow section 111 to be parallel to the liquid surface in the sample container 20.
[0085] In use, the injector 100 is inserted downwards from above the mounting plate 310, so that the injector tube 110 passes through the first placement hole until the mounting flange 130 abuts against the upper surface of the mounting plate 310. For removal, the injector 100 is moved upwards. For example, when the axes of the outflow section 111 and the inflow section 112 intersect, the maximum radial dimension of the entire injector tube 110 along the first placement hole is not greater than the diameter of the first placement hole, allowing the injector tube 110 to pass directly through the first placement hole.
[0086] Based on the second embodiment, in some embodiments of this utility model, reference is made to Figure 10 The density gradient system preparation apparatus 10 also includes a support component 500, which has a second placement hole for placing a sample container 20. For example, when the sample container 20 is a centrifuge tube, the support component 500 can be a centrifuge tube rack. The support component 500 has multiple second placement holes, enabling the batch transfer of multiple centrifuge tubes. In use, the support component 500 is placed on the support base 200. After the density gradient system preparation is completed, the support component 500 can move relative to the support base 200 and detach from it. For example, the support component 500 can be removed by the user and detached from the support base 200.
[0087] In some other embodiments, the support component 500 may be omitted, and instead, a second placement hole may be provided directly on the support base 200.
[0088] In some specific embodiments, the axis of the second placement hole is set in the vertical direction. When the injector 100 is in the set posture, the axis of the outflow section 111 is parallel to the horizontal direction. In this way, the outflow section 111 can enter or leave the sample container 20 through the relative movement in the vertical direction between the injector 100 and the sample container 20, and the outflow section 111 can be parallel to the liquid surface.
[0089] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof can be combined with each other unless otherwise specified.
Claims
1. A liquid injector for injecting liquid into a sample container at a predetermined injection posture, characterized in that, The injector includes an injection tube having an inlet for liquid inflow and an outlet for liquid outflow. The injection tube includes an outflow section with an outlet. When the injector is in the injection posture, the inner wall of the outflow section includes a bearing surface at the bottom of the inner wall. The bearing surface is continuously arranged and extends to the farthest end of the outflow section. The outlet is configured to allow liquid to flow out as it flows along the outflow section.
2. The injector according to claim 1, characterized in that, The outlet extends along the length of the outflow section, and the outlet has a first end along the length direction, the first end extending to the farthest end of the outflow section.
3. The injector according to claim 2, characterized in that, The first end extends to the bearing surface.
4. The injector according to claim 2, characterized in that, The outlet also has a second end along the length direction, wherein the distance between the bearing surface and the outlet gradually decreases along the direction from the second end to the first end.
5. The injector according to claim 1, characterized in that, The distal end of the outflow section is enclosed.
6. The injector according to claim 5, characterized in that, The outlet extends along the length of the outflow section, or there are multiple outlets, which are spaced apart along the length of the outflow section.
7. The injector according to claim 1, characterized in that, The injection tube further includes an inflow section, one end of which is connected to the outflow section, and the other end of which is provided with the inlet. The axis of the inflow section intersects with the axis of the outflow section.
8. The injector according to claim 7, characterized in that, The axis of the inflow section is perpendicular to the axis of the outflow section.
9. The injector according to claim 7, characterized in that, The injector also includes an inlet tube connected to the injection tube, the two ends of the inlet tube having an injection port and an outlet respectively, the outlet being connected to the inlet of the inflow section, and the cross-sectional area of the injection port being larger than the cross-sectional area of the inlet.
10. The injector according to claim 1, characterized in that, The inner wall of the outflow section is configured as an arc-shaped wall.
11. A device for preparing a density gradient system, characterized in that, include: The injector according to any one of claims 1 to 10; A support base for holding sample containers; The mounting bracket is connected to the support seat and is used to mount the injector in the injection posture.
12. The apparatus for preparing a density gradient system according to claim 11, characterized in that, The density gradient system preparation apparatus further includes a driving device, and the support is connected to at least one of the driving devices in the mounting frame. The driving device is configured to drive relative movement between the support and the mounting frame, and the relative movement has at least a vertical component.
13. The apparatus for preparing a density gradient system according to claim 11, characterized in that, The mounting bracket includes a mounting plate having a first placement hole. The injector also includes a mounting flange connected to the injection tube, the injection tube passing through the first placement hole, and the mounting flange abutting against the mounting plate to suspend the injector on the mounting plate.
14. The apparatus for preparing a density gradient system according to claim 11, characterized in that, The support has a second placement hole for placing the sample container; Alternatively, the density gradient system preparation apparatus may further include a support component having a second placement hole for placing the sample container, the support component being placed on the support seat and capable of moving relative to the support seat to detach from the support seat.
15. The apparatus for preparing a density gradient system according to claim 14, characterized in that, The axis of the second placement hole is set in the vertical direction, and when the injector is in the set posture, the axis of the outflow section is parallel to the horizontal direction.