Magnetic particle separation device
By using a combination design of a first magnet group and a second magnet group in the magnetic separation device, the problem of uneven distribution of magnetic particles on the reagent bottle wall is solved, achieving better separation effect and a larger separation volume or a smaller separator design.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- LONGLIGHT TECH CO LTD
- Filing Date
- 2025-07-29
- Publication Date
- 2026-05-12
AI Technical Summary
In existing magnetic separation devices, magnetic particles are unevenly distributed on the walls of reagent bottles, affecting subsequent processing.
The design employs a combination of a first magnet group and a second magnet group. The first magnet group forms a ring-shaped magnetic field, while the second magnet group has a magnetization direction opposite to that of the first magnet group at its end. This corrects the magnetic field to form a ring-shaped magnetic field with a larger radius, ensuring a uniform distribution of magnetic particles on the reagent bottle wall.
This method achieves uniform distribution of magnetic particles on the reagent bottle wall, improves the separation effect, and reduces the size of the separator or increases the separation volume while ensuring the separation effect.
Smart Images
Figure CN224221545U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of magnetic particle separation technology, specifically to a magnetic particle separation device. Background Technology
[0002] In the fields of biomedicine and chemical detection, magnetic particle separation technology is widely used for the extraction and purification of target substances such as proteins and nucleic acids. Magnetic separation devices typically use multiple magnets with specific magnetization directions relative to spatial angles to generate a quadrupole magnetic field within a cylindrical internal region enclosed by the magnets. This magnetic field has a ring-shaped magnetic field distribution in the horizontal plane, with the magnetic field gradient distributed radially along the ring. Magnetic particles move along the direction of the magnetic field gradient, thus achieving magnetic particle separation.
[0003] However, in actual use, the magnetic particles in existing magnetic separation devices move in a circular motion and eventually aggregate at certain locations on the bottle wall. This results in uneven distribution of the separated magnetic particles on the bottle wall, which is not conducive to the subsequent processing of the magnetic particles. Utility Model Content
[0004] This application primarily addresses the problem of uneven distribution of magnetic particles on the walls of reagent bottles.
[0005] According to a first aspect, one embodiment provides a magnetic particle separation device, comprising:
[0006] Magnetic container with a separation chamber;
[0007] The first magnet group includes a plurality of first magnets, which are arranged along the outer periphery of the separation cavity along the first circumference. Between two adjacent first magnets, the magnetization direction is Δα and the direction relative to the center of the circle is Δβ, and Δα = 3Δβ. The first magnet group forms a first magnetic field in the entire separation cavity.
[0008] The second magnet group includes at least one second magnet located at at least one end of the magnet container, and the second magnet is arranged along a second circumference on the outer periphery of the separation cavity. The diameter of the second circumference is smaller than the diameter of the first circumference. The magnetization direction of the second magnet group is opposite to the magnetization direction determined according to the magnetization direction law of the first magnet group. The second magnet group forms an adjustment to the first magnetic field at the end of the separation cavity.
[0009] In some embodiments, the second magnet is provided at both ends of the magnet container.
[0010] In some embodiments, the second magnet is arranged offset from the first magnet in the circumferential direction.
[0011] In some embodiments, the second magnet group includes four second magnets, and the angle between the directions of two adjacent second magnets relative to the center of the circle is 90 degrees.
[0012] In some embodiments, the first magnet group includes twelve first magnets, and the angle between two adjacent first magnets relative to the center direction is 30 degrees.
[0013] In some embodiments, the second magnet has an axial dimension of 5-20 mm in the separation cavity.
[0014] In some embodiments, the end face of the magnet container is provided with a receiving hole and a receiving groove, the receiving hole being used to receive the first magnet and the receiving groove being used to receive the second magnet.
[0015] In some embodiments, the magnetic particle separation device includes a fixing component comprising a fixing plate and a fastener, the fixing plate covering the end face of the magnet container and the fastener connecting the fixing plate to the magnet container.
[0016] In some embodiments, the magnetic particle separation device includes a cover plate connected to the magnet container, and the cover plate is provided with a clearance hole that is axially aligned with the separation chamber.
[0017] In some embodiments, the magnetic particle separation device includes a base connected to the magnet container and located at one end of the magnet container away from the cover plate.
[0018] According to the magnetic particle separation device of the above embodiment, the first magnet group forms a first magnetic field throughout the separation cavity; the second magnet group forms an adjustment to the first magnetic field at the end of the separation cavity; the magnetization direction of the second magnet group is opposite to the magnetization direction of the first magnet group, and the second magnetic field is used to correct the first magnetic field at the end of the separation cavity. The corrected first magnetic field has a ring magnetic field with a larger radius, and the magnetic particles are more evenly distributed on the reagent bottle wall after separation in the separation cavity. Attached Figure Description
[0019] Figure 1 This is a perspective view of one embodiment of the magnetic particle separation device of this application;
[0020] Figure 2 for Figure 1 A schematic diagram of the magnetic container in a medium-magnetic particle separation device;
[0021] Figure 3 for Figure 1 A schematic diagram showing the relative positions and magnetization directions of the first and second magnet groups in the medium magnetic particle separation device.
[0022] Figure label:
[0023] 100, Magnet container; 110, Separation chamber; 120, Receiving hole; 130, Receiving groove; 200, First magnet group; 210, First magnet; 300, Second magnet group; 310, Second magnet; 400, Cover plate; 410, Clearance hole; 420, Handle; 500, Base. Detailed Implementation
[0024] The present application will now be described in further detail with reference to the accompanying drawings and specific embodiments. Similar elements in different embodiments are referred to by related similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of the present application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to the present application are not shown or described in the specification. This is to avoid obscuring the core parts of the present application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.
[0025] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.
[0026] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the described objects and have no sequential or technical meaning. The terms "connection" and "linkage" used in this application, unless otherwise specified, include both direct and indirect connections (linkages).
[0027] Magnetic separation devices typically use a magnet array within a separation chamber to create a ring-shaped magnetic field distribution in a horizontal plane. The magnetic field gradient is distributed radially along the ring, and magnetic particles move along the direction of the magnetic field gradient, thus achieving magnetic particle separation, as illustrated in Chinese Patent CN101208153B. However, in practical use, existing magnetic separation devices often result in magnetic particles agglomerating at certain locations on the reagent bottle wall. This leads to uneven distribution of the separated magnetic particles on the bottle wall, hindering subsequent processing of the magnetic particles.
[0028] The inventors of this application have discovered that for a magnet that generates a magnetic field, the magnetic field in the horizontal plane at the top and bottom regions deviates from a circular shape in the outer region with a larger radius. This generates a circumferential magnetic field gradient component, causing magnetic particles to move circumferentially and aggregate, affecting the separation effect. If the magnetic field in the separation area of the magnetic particles is to remain circular in the top and bottom regions of the magnet, the radius of the separation zone is small. To achieve the separation of the same volume of reagent, a larger magnetic field and separator are required, which is inconvenient to use.
[0029] To address the aforementioned issues, a first magnet group and a second magnet group can be configured. The first magnet group forms a ring-shaped magnetic field for separating magnetic particles. A second magnet group is positioned at the end of the first magnet group, with its magnetization direction opposite to that of the first magnet group. This corrects the first magnetic field, resulting in a ring-shaped magnetic field with a larger radius, thus resolving the problem of uneven magnetic particle distribution.
[0030] like Figures 1-3 As shown, one embodiment provides a magnetic particle separation device, including: a magnet container 100, a first magnet group 200, and a second magnet group 300.
[0031] The magnetic container 100 has a separation cavity 110. The magnetic container 100 can be cylindrical, and the separation cavity 110 is a cylindrical space formed in the middle of the magnetic container 100. The separation cavity 110 is used to contain a reagent bottle containing magnetic particles. The magnetic particles move towards the wall of the reagent bottle under the action of a magnetic field in the separation cavity 110, thereby achieving the separation effect.
[0032] The first magnet group 200 includes a plurality of first magnets 210, which are arranged along the outer periphery of the separation cavity 110 along a first circumference. The first magnet group 200 forms a first magnetic field within the entire separation cavity 110. Between two adjacent first magnets 210, the angle between their magnetization directions is Δα, and the angle between their directions relative to the center of the circle is Δβ, where Δα = 3Δβ. In the first magnet group 200, each first magnet 210 can be arranged along the axial direction of the magnet container 100 and penetrate the entire magnet container 100 to form a first magnetic field within the entire separation cavity 110.
[0033] The second magnet assembly 300 includes at least one second magnet 310, which is located at at least one end of the magnet container 100. Unlike the first magnet 210, which extends throughout the entire magnet container 100, the second magnet 310 is located only at the end of the magnet container 100. In this embodiment, the second magnet 310 is provided at both the top and bottom of the magnet container 100. In other embodiments, the second magnet 310 may be located at either the top or bottom of the magnet container 100.
[0034] When the second magnet assembly 300 includes a plurality of second magnets 310, at one end of the magnet container 100, the plurality of second magnets 310 are arranged along a second circumference on the outer periphery of the separation cavity 110. The diameter of the second circumference is smaller than the diameter of the first circumference, that is, the second magnet assembly 300 is located inside the first magnet assembly 200 and is disposed close to the first magnet assembly 200. The second magnet assembly 300 forms a second magnetic field at the end of the separation cavity 110 and is used to correct the first magnetic field at the end of the separation cavity 110.
[0035] The magnetization direction of the second magnet group 300 is opposite to the magnetization direction determined according to the magnetization direction rule of the first magnet group 200. This opposite magnetization direction can be understood as follows: the magnetization direction of the second magnet 310 is opposite to the magnetization direction of the first magnet 210, which is assumed to be located at that position. Furthermore, within the second magnet group 300, the numerical relationship between two adjacent second magnets 310 still holds true; that is, between two adjacent second magnets, the angle between their magnetization directions is Δα, the angle between their directions relative to the center is Δβ, and Δα = 3Δβ.
[0036] The first magnet 210 and the second magnet 310 can have any shape, such as a cuboid, a polygonal prism, a cylinder, an elliptical cylinder, etc.
[0037] The arrangement of the first magnet group 200 and the second magnet group 300 enables the formation of a ring-shaped magnetic field on a horizontal plane within the separation chamber 110, with the magnetic field gradient distributed radially. When a reagent bottle containing a suspension of magnetic particles is placed within the separation chamber 110, effective separation of the magnetic particles is achieved, resulting in a more uniform distribution of the particles on the bottle wall. Only a weak residual magnetic field is formed outside the outer wall of the magnet container 100.
[0038] Meanwhile, the placement of the first magnet group 200 and the second magnet group 300 in the top and bottom regions can achieve a larger radius annular magnetic field, improving the magnetic particle separation effect; or, while ensuring the magnetic particle separation effect, increase the effective volume of magnetic particle separation: for reagents of a specific volume, the size and weight of the separator can be reduced, and for separators of the same size, magnetic particle separation of larger volume reagents can be achieved.
[0039] In some embodiments, such as Figure 3 As shown, the first magnet group 200 includes twelve first magnets 210, with the angle between any two adjacent first magnets 210 relative to their center being 30 degrees. The second magnet group 300 includes four second magnets 310, with the angle between any two adjacent second magnets 310 relative to their center being 90 degrees. The second magnets 310 and the first magnets 210 are staggered in the circumferential direction.
[0040] In some embodiments, the second magnet 310 may have an axial dimension of 5-20 mm in the separation cavity 110. Preferably, the second magnet 310 has an axial dimension of 5-10 mm in the separation cavity 110.
[0041] In some embodiments, such as Figure 2 As shown, the magnet container 100 has a receiving hole 120 and a receiving groove 130 on its end face. The receiving hole 120 is used to receive a first magnet 210, and the receiving groove 130 is used to receive a second magnet 310. Multiple receiving holes 120 can be provided and extend through the magnet container 100. Multiple receiving holes 120 are arranged along a first circumference on the magnet container 100. The specific number of receiving holes 120 is determined according to the number of first magnets 210 in the first magnet group 200. The shape of the receiving hole 120 can be adapted to the shape of the first magnet 210.
[0042] A receiving groove 130 is disposed on the top and / or bottom of the magnet container 100. In this embodiment, both the top and bottom of the magnet container 100 are provided with receiving grooves 130. Multiple receiving grooves 130 can be provided, arranged along the second circumference on the magnet container 100, i.e., located inside the receiving hole 120. The specific number of receiving grooves 130 is determined according to the number of second magnets 310 in the second magnet group 300. The shape of the receiving groove 130 can be adapted to the shape of the second magnet 310.
[0043] The magnetic particle separation device may also include a fixing component, which includes a fixing plate and fasteners. The fixing plate covers the end face of the magnet container 100, and the fasteners connect the fixing plate to the magnet container 100. The fixing component can fix the first magnet group 200 and the second magnet group 300 to the magnet container 100.
[0044] The magnetic particle separation device may further include a cover plate 400 and a base 500. The cover plate 400 is connected to the magnetic container 100. The cover plate 400 is provided with a clearance hole 410, which is axially aligned with the separation chamber 110 to allow reagent bottles placed in the separation chamber 110 to pass. The cover plate 400 is provided with a handle 420. The base 500 is connected to the magnetic container 100 and is located at the end of the magnetic container 100 away from the cover plate 400. The base 500 is provided to support the magnetic container 100.
[0045] In the magnetic particle separation device of the above embodiment, the first magnet group 200 forms a first magnetic field throughout the separation chamber 110; the second magnet group 300 forms a second magnetic field at the end of the separation chamber 110; the magnetization direction of the second magnet group 300 is opposite to the magnetization direction of the first magnet group 200. The second magnetic field is used to correct the first magnetic field at the end of the separation chamber 110. The corrected first magnetic field has a ring magnetic field with a larger radius. When the magnetic particles are located in the ring magnetic field, the separation effect is better and the distribution on the reagent bottle wall is more uniform.
[0046] The above examples illustrate this application only to aid understanding and are not intended to limit its scope. Those skilled in the art to which this application pertains can make various simple deductions, modifications, or substitutions based on the ideas presented.
Claims
1. A magnetic particle separation device, characterized in that, include: Magnetic container with a separation chamber; The first magnet group includes a plurality of first magnets, which are arranged along the outer periphery of the separation cavity along the first circumference. Between two adjacent first magnets, the magnetization direction is Δα and the direction relative to the center of the circle is Δβ, and Δα = 3Δβ. The first magnet group forms a first magnetic field in the entire separation cavity. The second magnet group includes at least one second magnet located at at least one end of the magnet container, and the second magnet is arranged along a second circumference on the outer periphery of the separation cavity. The diameter of the second circumference is smaller than the diameter of the first circumference. The magnetization direction of the second magnet group is opposite to the magnetization direction determined according to the magnetization direction law of the first magnet group. The second magnet group forms an adjustment to the first magnetic field at the end of the separation cavity.
2. The magnetic particle separation device according to claim 1, characterized in that, The second magnet is provided at both ends of the magnet container.
3. The magnetic particle separation device according to claim 2, characterized in that, The second magnet is staggered from the first magnet in the circumferential direction.
4. The magnetic particle separation device according to claim 3, characterized in that, The second magnet group includes four second magnets, and the angle between the directions of two adjacent second magnets relative to the center of the circle is 90 degrees.
5. The magnetic particle separation device according to claim 4, characterized in that, The first magnet group includes twelve first magnets, and the angle between two adjacent first magnets relative to the center direction is 30 degrees.
6. The magnetic particle separation device according to claim 1, characterized in that, The second magnet has an axial dimension of 5-20 mm in the separation cavity.
7. The magnetic particle separation device according to any one of claims 1-6, characterized in that, The end face of the magnet container is provided with a receiving hole and a receiving groove. The receiving hole is used to receive the first magnet, and the receiving groove is used to receive the second magnet.
8. The magnetic particle separation device according to claim 7, characterized in that, The device includes a fixing component, which comprises a fixing plate and a fastener. The fixing plate covers the end face of the magnet container, and the fastener connects the fixing plate to the magnet container.
9. The magnetic particle separation device according to claim 7, characterized in that, Includes a cover plate, which is connected to the magnet container, and the cover plate is provided with a clearance hole, which is axially aligned with the separation cavity.
10. The magnetic particle separation device according to claim 9, characterized in that, Includes a base, which is connected to the magnet container and located at the end of the magnet container away from the cover plate.