Nitrogen charging sealing device

Abstract

The utility model provides a nitrogen-filled sealing device which comprises a base, a nitrogen-filled sealing device and a nitrogen-filled sealing device. The base supports a penicillin bottle; the protective shell is arranged above the base, the protective shell is configured to cover the penicillin bottle, a containing space is formed in the protective shell, the protective shell is provided with a through hole, and the through hole is configured to receive the protective gas filled in the containing space so that the penicillin bottle can contain the protective gas; the first lifting mechanism is connected with the protective shell, and the first lifting mechanism drives the protective shell to move relative to the base in the vertical direction; and the adsorption pressing piece is arranged in the protection shell and can move in the vertical direction, and the adsorption pressing piece is configured to suck up a bottle plug of the penicillin bottle and press a bottle opening of the penicillin bottle. According to the nitrogen filling and sealing device, the risk that radiopharmaceutical overflows in the nitrogen filling and sealing process of the penicillin bottle can be reduced, and the convenience and safety of sealing and nitrogen filling are improved.

Description

Technical Field

[0001] This application belongs to the field of packaging equipment technology, and in particular relates to a nitrogen-filling sealing device. Background Technology

[0002] Radiopharmaceuticals are an important class of drugs with wide clinical applications and broad market prospects. These drugs are mostly stored in vials, and because they are radioactive and have poor stability, filling the vials with an inert gas, such as nitrogen, can increase the stability of the radiopharmaceuticals and extend their shelf life. At the same time, to protect operators and reduce the hazards caused by radiation, automated equipment is needed to perform the inert gas filling process.

[0003] In related technologies, due to the potential risk of drug spillage leading to radioactive contamination, directly aiming the nitrogen filling needle at the vial and the drug solution presents several problems. Insufficient airflow results in ineffective nitrogen filling, while excessive airflow can cause radioactive aerosol spillage and radioactive contamination. Furthermore, the vial sealing process requires negative pressure, under which nitrogen filling is ineffective and unstable. Utility Model Content

[0004] This application provides a nitrogen-filling and sealing device that can reduce the risk of radioactive drug spillage during nitrogen filling and sealing of vials, and improve the convenience and safety of sealing and nitrogen filling.

[0005] An embodiment of the first aspect of this application provides a nitrogen-filling and sealing device, comprising: a base supporting a vial; a protective shell disposed above the base, configured to cover the outside of the vial and forming a receiving space inside the protective shell, the protective shell having a through hole configured to receive protective gas filled into the receiving space, so that the vial contains protective gas; a first lifting mechanism connected to the protective shell, the first lifting mechanism driving the protective shell to move relative to the base in a vertical direction; and an adsorption and pressing member disposed inside the protective shell and movably disposed in a vertical direction, the adsorption and pressing member being configured to adsorb the vial stopper and press the vial mouth to realize the opening and closing of the vial mouth.

[0006] In some embodiments, the adsorption and clamping member includes a body and a first ventilation channel formed by the body. The end face of the body near the base includes a recess and a protrusion located around the recess. The first ventilation channel is configured to control the recess depth of the recess under different air pressures to achieve adsorption and clamping of the vial stopper.

[0007] In some embodiments, the protective shell includes a top wall and a side wall, the side wall being connected to the top wall, and a through hole being disposed on the side wall, the through hole being located above the mouth of the vial in the vertical direction.

[0008] In some embodiments, a first opening is provided at the top of the protective shell, and the nitrogen filling and sealing device includes a second lifting mechanism, which includes a top rod; one end of the top rod near the base is connected to the adsorption and pressing member, driving the adsorption and pressing member to move in the vertical direction; the top rod passes through the first opening.

[0009] In some embodiments, the second lifting mechanism further includes a sealing element, which is sleeved on the outside of the top rod and disposed in the first opening to seal the first opening; the top rod is movably disposed in the vertical direction to drive the adsorption and clamping element to press the vial stopper.

[0010] In some embodiments, the top rod includes a second venting channel disposed therein, which communicates with a first venting channel; the nitrogen filling and sealing device includes an air pump and an air filling pipe communicating with the air pump, the air filling pipe being configured to introduce gas into the second venting channel.

[0011] In some embodiments, the nitrogen-filling sealing device includes a movable component connected to a base, and the movable base is also included.

[0012] In some embodiments, the protective shell is provided with a second opening, which is disposed vertically opposite to the top wall, and the second opening divides the protective shell into a first protective shell and a second protective shell.

[0013] In some embodiments, the protective shell includes a third opening facing the base, and the base blocks the third opening so that the protective shell forms a receiving space.

[0014] In some embodiments, the nitrogen-filling sealing device includes: a support rod disposed on one side of the protective shell; and one end of a second lifting mechanism connected to the support rod.

[0015] In the nitrogen-filling and sealing device provided in this application embodiment, the base supports the vial; a protective shell is disposed above the base and is configured to cover the outside of the vial. The protective shell is vertically movable via a first lifting mechanism, reducing the movement of the vial and minimizing the leakage of radioactive material. The protective shell has a through hole configured to receive protective gas filled into the containment space. When the protective shell descends, the adsorption and clamping member lifts the vial stopper, allowing the protective gas to fill the protective shell through the through hole. The protective gas then enters the vial. After filling, the adsorption and clamping member seals the vial opening with the vial stopper, leaving the protective gas in the sealed vial. The protective gas protects the radiopharmaceutical in the vial and extends its shelf life. Furthermore, the process of filling the protective gas takes place within the relatively sealed containment space formed by the protective shell, effectively reducing the oxygen content in the containment space and achieving the purpose of reducing the oxygen content in the vial and filling it with protective gas. Attached Figure Description

[0016] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments of this application will be briefly introduced below. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This paper shows a schematic diagram of a nitrogen-filling and sealing device for vials according to an embodiment of this application;

[0018] Figure 2 This illustration shows a schematic diagram of a nitrogen-filling and sealing device for vials according to yet another embodiment of this application;

[0019] Figure 3 A schematic diagram of the protective shell and base according to an embodiment of this application is shown;

[0020] Figure 4 A schematic diagram of the protective shell and base according to yet another embodiment of this application is shown;

[0021] Figure 5 This is a cross-sectional view of a protective shell provided in one embodiment of this application;

[0022] Figure 6 A schematic diagram of the structure of an adsorption clamping component according to an embodiment of this application is shown;

[0023] Figure 7 This illustration shows a structural schematic diagram of yet another adsorption clamping member according to yet another embodiment of the present application;

[0024] Figure 8 This is a cross-sectional view of the top rod assembly at the protective shell provided in one embodiment of this application.

[0025] Explanation of reference numerals in the attached figures:

[0026] 100. Nitrogen filling and sealing device; 10. Adsorption and pressing component; 11. First ventilation channel; 12. Recess; 13. Protrusion; 20. Protective shell; 21. Through hole; 22. First protective shell; 23. Second protective shell; 24. Second opening; 25. Third opening; 30. Base; 40. Support rod; 50. Outer shell; 60. Moving mechanism; 61. Guide rod; 62. Cylinder; 70. Second lifting mechanism; 71. Top rod; 72. Groove; 80. First lifting mechanism. Detailed Implementation

[0027] The features and exemplary embodiments of various aspects of this application will now be described in detail. Numerous specific details are set forth in the following detailed description to provide a comprehensive understanding of this application. However, it will be apparent to those skilled in the art that this application can be implemented without requiring some of these specific details. The following description of embodiments is merely intended to provide a better understanding of this application by illustrating examples. In the accompanying drawings and the following description, at least some well-known structures and techniques are not shown to avoid unnecessarily obscuring the application; and, for clarity, the dimensions of some structures may be exaggerated. Furthermore, the features, structures, or characteristics described below can be combined in any suitable manner in one or more embodiments.

[0028] In the description of this application, it should be noted that, unless otherwise stated, the terms "first direction," "second direction," etc., indicating orientation or positional relationship are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0029] The directional terms appearing in the following description refer to the directions shown in the figures and are not intended to limit the specific structure of the embodiments of this application. It should also be noted in the description of this application that, unless otherwise explicitly specified and limited, the terms "installation" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0030] In related technologies, radiopharmaceuticals are often packaged in vials. Radiopharmaceuticals are sensitive to oxygen and moisture, which can affect their active ingredients. Therefore, filling the vials with a protective gas can prevent oxidative degradation, extend shelf life, and reduce free radical reactions. Given the poor stability of these radiopharmaceuticals, it is necessary to fill the vials with a protective gas, such as an inert gas or nitrogen. To protect operators and reduce hazards from radiation, automated equipment is generally used to fill the vials with the inert gas.

[0031] Automated equipment for inert gas filling is generally large in size. The maximum production batch of radiopharmaceuticals is only a few hundred vials, requiring operation within the confined space of a shielded enclosure; large equipment is unsuitable for radiopharmaceutical production. Furthermore, inert gas filling typically requires negative pressure conditions, resulting in poor and unstable filling efficiency and posing a risk of radioactive contamination. In related technologies, the nitrogen filling needle is directly aimed at the liquid in the vial; insufficient airflow leads to ineffective filling, while excessive airflow can cause radioactive aerosols to escape, resulting in radioactive contamination.

[0032] To better understand this application, this application uses vials as an example, combined with... Figures 1 to 4 The nitrogen-filling and sealing device for vials according to embodiments of this application will be described in detail.

[0033] Figure 1 A schematic diagram of the nitrogen-filling and sealing device for vials according to an embodiment of this application is shown. Figure 2 A schematic diagram of the structure of a nitrogen-filled sealing device for a vial, as described in another embodiment of this application, is shown.

[0034] Please see Figure 1 The nitrogen-filling and sealing device 100 includes: a base 30 supporting a vial; a protective shell 20 disposed above the base 30, configured to cover the outside of the vial and forming an accommodating space inside the protective shell 20, the protective shell 20 having a through hole 21 configured to receive protective gas filled into the accommodating space, so that the vial can contain protective gas; a first lifting mechanism 80 connected to the protective shell 20, the first lifting mechanism 80 driving the protective shell 20 to move relative to the base 30 in a vertical direction; and an adsorption and pressing member 10 disposed inside the protective shell 20 and movable in a vertical direction, the adsorption and pressing member 10 configured to lift the vial stopper and press the vial mouth to realize the opening and closing of the vial mouth.

[0035] The nitrogen-filling and sealing device 100 can be used to fill vials containing radiopharmaceuticals with nitrogen and to open and close the stoppers of vials.

[0036] It is understandable that the containment space refers to a relatively sealed space, which can reduce the oxygen content, moisture content, etc., of the space as a protective gas is introduced, so that the vial can contain or be filled with the protective gas.

[0037] The base of the nitrogen-filled and sealed vial device provided in this application supports the vial. A protective shell is positioned above the base and is configured to cover the outside of the vial. The protective shell is vertically movable via a first lifting mechanism, reducing vial movement and thus reducing the leakage of radioactive material. The protective shell has a through-hole configured to receive protective gas filled into the containment space. When the protective shell descends, the adsorption and clamping member lifts the vial stopper, allowing protective gas to fill the protective shell through the through-hole. The protective gas then enters the vial. After filling, the adsorption and clamping member seals the vial opening with the vial stopper, ensuring the protective gas remains in the sealed vial. This protective gas protects the radiopharmaceutical in the vial and extends its shelf life. Furthermore, the filling of the protective gas occurs within the relatively sealed containment space formed by the protective shell, effectively reducing the oxygen content within the space and achieving the goal of reducing the oxygen content in the vial and filling it with protective gas.

[0038] The nitrogen-filling and sealing device 100 of this application embodiment is small in size and easy to move flexibly, meeting the needs of radiopharmaceutical production in small spaces and small batches, such as operation inside a radioactive shielding box. This nitrogen-filling and sealing device 100 solves the problem of poor and unstable nitrogen filling effect under negative pressure conditions. By using a protective gas filling method with a protective shell 20, the influence of negative pressure can be reduced, ensuring a better effect of protective gas filling. The base 30 can serve as the basic component of the nitrogen-filling and sealing device 100 for vials, and also provides support for the vials. The base 30 needs to have a certain base structure to be stably placed on the operating table. Optionally, the base 30 can be a rectangular, trapezoidal, L-shaped plate, or T-shaped plate structure. The protective shell 20 can be installed on the base 30. The base 30 can be made of stainless steel, aluminum alloy, or other materials.

[0039] The base 30 can accommodate vials with a diameter of 20mm to 35mm. The base 30 is made of stainless steel or aluminum alloy. The vial receiving hole is designed with an inflation and compression device.

[0040] In some embodiments, the base 30 is provided with a groove; the outline of the groove matches the projection of the bottom of the protective shell 20.

[0041] For example, when the protective shell and the base can form a receiving space, a receiving space is formed between the protective shell 20 and the base 30 when the protective shell 20 descends into the groove. Optionally, an elastic element is provided in the groove.

[0042] The protective shell 20 and the base 30 can be combined to form a receiving space, which can be from top to bottom, from front to back, or from left to right, or other combinations.

[0043] The guide rail is a linear slide rail, and the cylinder 62 can be a two-way cylinder 62. The bottom end of the protective shell 20 has a limiting protrusion for positioning and engagement with the base 30. The forward and backward movement of the base 30 matches the infeed distance of the vial. An elastic element is provided in the groove, creating a receiving space between the protective shell 20 and the base 30 when the protective shell 20 descends into the groove.

[0044] Please continue reading Figure 2 The nitrogen-filling sealing device 100 includes a moving component connected to the base 30 and providing driving force for the movement of the base 30, causing the base 30 to move along a second direction. The moving component includes a guide rail and a cylinder 62. The base 30 is disposed on the guide rail and moves along the guide rail under the drive of the cylinder 62. The second direction can be parallel to the plane of the base 30. The second direction can be perpendicular to the first direction. Optionally, the moving component is selected from the cylinder 62 or an electric cylinder. The protective shell 20 is vertically movable relative to the base 30. The protective shell 20 is movably connected to the surface or end of the base 30 and can move toward or away from the base 30. The protective shell 20 is cylindrical in shape, but can also be cuboid or other cubic shapes. The protective shell 20 is used to fill with protective gases such as nitrogen and argon to prevent leakage of radioactive materials. The cylindrical diameter of the protective shell 20 can range from 30 to 120 mm, and can be 45 mm. The protective case 20 can be made of stainless steel, but acrylic, aluminum alloy, titanium alloy, lead composite material, or polymer coating are also acceptable. Stainless steel options include 304 / 316L. The protective case 20 can have a double-layer shell structure. Its shape can be cylindrical, cuboid, etc. The diameter of the cylindrical base can be 4.5cm or 10.5cm, etc. The dimensions of the cuboid can be 8*7.5*10cm, 8.5*4.2*9.7cm, etc.

[0045] Figure 3 A schematic diagram of the protective shell and base according to an embodiment of this application is shown. The protective shell has a second opening 24, which is vertically aligned with the top wall. The second opening 24 divides the protective shell 20 into a first protective shell 22 and a second protective shell 23, creating a receiving space between them. It is understood that the first protective shell 22 can be the upper protective shell, and the second protective shell 23 can be the lower protective shell. When the first protective shell 22 and the second protective shell 23 are closed, an exhaust slit is formed corresponding to the second opening 24, allowing atmospheric air to escape from the protective shell when it is filled with protective gas. Alternatively, the protective shell may have other exhaust slits.

[0046] Figure 4A schematic diagram of the protective shell and base according to another embodiment of this application is shown. The protective shell 20 includes a third opening 25 facing the base 30, and the base 30 seals the third opening 25 to form an accommodating space. When the protective shell 20 and the base 30 form the accommodating space, an exhaust slit is formed corresponding to the position of the third opening 25 to allow atmospheric air to escape from the protective shell when it is filled with protective gas. Alternatively, the protective shell may have other exhaust slits.

[0047] The upper part of the protective shell can be connected to the first lifting mechanism 80. One end of the first lifting mechanism 80 can be connected to the support rod 40. The upper protective shell 20 and the lower protective shell 20 can form an accommodating space.

[0048] Please continue reading Figure 2 The nitrogen filling and sealing device 100 includes a first lifting mechanism 80, which is connected to the protective shell 20. The first lifting mechanism 80 drives the protective shell 20 to move vertically relative to the base 30. The first lifting mechanism 80 can be any one of an electric screw lifting mechanism, a cam lifting mechanism, or a cylinder 62 lifting mechanism.

[0049] Figure 5 This is a cross-sectional view of a protective shell provided in one embodiment of this application.

[0050] Please see Figure 5 The protective shell 20 includes a top wall and a side wall, with the side wall connected to the top wall. A through hole 21 can be located at any position on the protective shell 20. Optionally, the through hole 21 is located on the side wall or the top wall. The through hole 21 is located vertically above or below the mouth of the vial, optionally above. In some embodiments, the through hole is closer to the top wall than the mouth of the vial.

[0051] The vertical distance d between the through-hole 21 and the mouth of the vial is 0.1cm to 2cm, and can be selected as 0.5cm, 1cm, 1.5cm, etc. The through-hole 21 of this nitrogen-filling sealing device 100 is not directly aligned with the radiopharmaceutical, such as liquid radiopharmaceutical, inside the vial, thus avoiding direct purging of the liquid and reducing the risk of radioactive aerosol leakage.

[0052] Furthermore, the through-hole 21 can be located anywhere on the surface of the protective shell 20. Multiple through-holes 21 can be provided.

[0053] Different protective shell shapes can correspond to different protective gas flow rates and durations to achieve low oxygen levels at the top of the vial, thereby evaluating the effectiveness of filling the vial with protective gas. When the oxygen content at the top of the vial is ≤4%, optionally ≤3.8%, and further optionally ≤2%, the filling of the vial with protective gas can be stopped. The gas flow rate and duration can be controlled according to this standard. The top of the vial can be understood as the vertical distance from the vial opening to 1 / 4 of the height inside the vial; alternatively, it can be the distance from the vial opening to 1 / 5 of the vial's internal height. Examples are shown in Table 1.

[0054] Table 1.

[0055]

[0056]

[0057] The adsorption and clamping component 10 is located inside the protective housing 20, and the end of the adsorption and clamping component 10 facing away from the base is connected to the second lifting mechanism 70. The end of the adsorption and clamping component 10 near the base is used to contact the bottle stopper to achieve adsorption and clamping of the bottle stopper. The bottle stopper can be a rubber stopper.

[0058] The end can be spherical, conical, or curved. It can be flexible to prevent damage to the stopper surface. The end can be a conical or curved surface that mates with the bottom of the stopper, pressing the stopper into the bottle neck and sealing it through axial thrust. The suction clamping element 10 can be a hollow structure.

[0059] In some embodiments, the adsorption and pressing member 10 includes a body and a first ventilation channel 11. The first ventilation channel 11 is located outside the body. The end face of the body near the base includes a recess 12 and a protrusion 13 located around the recess. The first ventilation channel 11 is configured to control the recess depth of the recess 12 under different air pressures to achieve adsorption and pressing of the vial stopper.

[0060] The end face is a solid surface, and the concave part 12 and the convex part 13 are solid parts, so the gas in the first ventilation channel 11 cannot leak out from the end face.

[0061] Figure 6 A schematic diagram of the structure of an adsorption clamping component according to an embodiment of this application is shown.

[0062] from Figure 6As can be seen, the recess 12 is deeper than the protrusion 13. A negative pressure is created within the first ventilation channel 11, or the channel is not fully filled with gas, causing the recess 12 to sink and adsorb the vial stopper. Therefore, when the nitrogen-filled sealing device is in the open position, the middle portion corresponding to the recess 12 and the vial stopper is tightly adsorbed. The vial stopper sinks along the vertical direction of the recess 12 away from the base, adsorbing the vial stopper. The protrusion 13 of the adsorption and pressing member 10 is close to the side wall of the vial stopper, assisting in opening the vial and thus opening the vial.

[0063] Figure 7 A schematic diagram of the structure of yet another adsorption clamping member according to yet another embodiment of this application is shown.

[0064] from Figure 7 As can be seen, the recess 12 is shallower than the protrusion 13, possibly because it is filled with gas in the first venting channel 11. The recess 12 is either normal or bulging towards the base, thus pressing against the vial stopper. During the process of sealing the vial opening with nitrogen filling, the recess 12 is in close contact with the corresponding middle part of the vial stopper, and the depth of the recess 12 decreases, pressing against the corresponding middle part of the vial stopper towards the vial opening, thereby sealing the vial opening with the vial stopper.

[0065] The first ventilation channel 11 of the adsorption clamping component 10 can be connected to a vacuum pump or an air pump, creating a negative pressure when it approaches the bottle stopper, thus adsorbing the bottle stopper. The edge of the adsorption clamping component 10 can also be a conical structure to facilitate pressing the bottle stopper in. The adsorption clamping component 10 can be made of silicone and is used to adsorb the bottle stopper; after adsorption is completed, it moves downward by mechanical drive; this mechanical drive can be a cylinder or a servo motor.

[0066] The protective shell 20 has a first opening at the top. The second lifting mechanism 70 includes a top rod 71 and a sealing element. The top rod 71 passes through the first opening, and the sealing element is sleeved on the outside of the top rod 71 and set in the first opening to seal the first opening. The second lifting mechanism 70 is movably arranged in the vertical direction to drive the adsorption and pressing element 10 to press the vial stopper.

[0067] The top rod 71 includes a second ventilation channel disposed inside, which communicates with the first ventilation channel 11; the nitrogen filling and sealing device also includes an air pump and an air filling pipe connected to the air pump, the air filling pipe being configured to introduce gas into the second ventilation channel. The air filling pipe may also be configured to introduce gas into the first ventilation channel 11.

[0068] The push rod 71 can be a solid or hollow rod, capable of axial extension, retraction, or sliding. Axial extension and retraction of the push rod 71 can be driven by a cylinder 62 or an electric push rod. The push rod 71 can be extended or retracted by a piston driven by compressed air; alternatively, it can be extended or retracted by a servo motor driving a lead screw or rack. The length of the push rod 71 can be 10–12 mm, and its lifting height ranges from 5–50 mm, enabling it to pick up vial stoppers.

[0069] The push rod 71 is equipped with a limiting structure to control its extension or retraction distance, ensuring consistent stopper clamping depth. The limiting structure can be a limiting groove or a threaded section, allowing it to be positioned at multiple fixed locations to facilitate control of the stopper's insertion depth, making it suitable for vials of different sizes or stoppers of different heights. The push rod 71 can be made of high-hardness metal materials such as steel or iron.

[0070] A sealing element, sleeved on the outside of the top rod 71 and located in the first opening, is used to seal the protective shell 20.

[0071] The seal can be an elastic element, fitted onto the push rod 71, which connects to the protective shell 20 via the elastic element. The friction between the elastic element and the protective shell 20, and between the elastic element and the push rod 71, is low, thus ensuring a tight seal between the protective shell 20 and the push rod 71. Optionally, the elastic element can be a high-temperature resistant, wear-resistant elastic gasket. As an example, the seal can be fixedly installed on the inner edge of the opening of the protective shell 20. The seal can be a flexible sealing gasket or a silicone ring, made of materials such as silicone rubber or EPDM rubber. The seal can be an O-ring, lip seal, or corrugated seal. The seal and the push rod 71 have an interference fit to ensure sealing performance.

[0072] Figure 8 This is a cross-sectional view of the top rod assembly at the protective shell provided in one embodiment of this application.

[0073] See also Figure 8 The push rod 71 has a groove 72 on the side facing the seal, and the seal is disposed in the groove 72. The position of the groove 72 matches the first opening of the protective shell 20.

[0074] In these optional embodiments, the seal is disposed within the groove 72 of the push rod 71, forming a fitting structure with the groove 72. This fitting structure serves a positioning function, fixing the position of the seal, simplifying the assembly process of the seal, and simultaneously increasing the connection area between the seal and the push rod 71, thereby increasing contact stability and improving connection strength. When the seal is an elastic element, the pressure on the push rod 71 can be reduced, decreasing the risk of seal rupture or deformation.

[0075] In some embodiments, the seal may be an elastic gasket; the groove is an annular groove for accommodating the elastic gasket, and the groove depth of the annular groove along the first direction is less than the width of the elastic gasket along the first direction.

[0076] In these optional embodiments, the seal can be an elastic washer, and the push rod 71 has an annular groove for accommodating the elastic washer. The annular groove is recessed relative to the surface of the push rod 71 facing the elastic element. The insertion of the seal into the annular groove forms a fitting structure, and the protrusion of the elastic washer adheres to the groove wall of the annular groove. When the cover plate rotates, the annular groove can also restrict the seal in the first direction, improving the stability of the seal. In addition, the groove depth of the annular groove is less than the width of the elastic washer, that is, the elastic washer protrudes from the end face of the push rod 71, playing a buffering role.

[0077] See Figure 1 and Figure 2 The nitrogen-filling sealing device 100 includes: a support rod 40, disposed on one side of the protective shell 20. One end of the second lifting mechanism 70 is connected to the support rod 40. One end of the top rod 71 is connected through the second lifting mechanism 70. The nitrogen-filling sealing device 100 also includes: an outer shell 50, which is fitted over the protective shell 20 and the base 30 to protect the internal structure and improve aesthetics.

[0078] It is understood that the nitrogen filling and sealing device 100 also includes an inflation assembly. The inflation assembly is located on one side of the support rod 40. The inflation assembly includes an inflation tube, one end of which is inserted into and seals the through hole 21, for introducing protective gas into the protective shell 20.

[0079] The method of using the nitrogen-filling and sealing device 100 of this application includes: opening the protective shell and placing a vial containing radiopharmaceuticals into it. The vial has a stopper and is sealed, making the protective shell airtight. When the mouth of the vial is blocked by the vial stopper, the adsorption and clamping member 10 lifts the vial stopper inside the protective shell 20. When the mouth of the vial is not blocked, the gas delivery tube introduces protective gas such as nitrogen through the through hole 21. The protective gas is introduced into the protective shell 20 at a certain flow rate. After a period of time, the top rod 71 and / or the adsorption and clamping member 10 are lowered to press the vial stopper, completing the filling and sealing of the protective gas. Then, the vial is removed from the protective shell 20. After the nitrogen filling and sealing are completed, the protective shell 20 and the base 30 return to their initial positions, and the filling of the protective gas is finished.

[0080] The nitrogen-filling and sealing device 100 of this application embodiment can be used in conjunction with a vial capping device to achieve both protective gas filling and stopper pressing, thus realizing an integrated capping operation.

[0081] Although this application has been described with reference to preferred embodiments, various modifications can be made thereto and components can be replaced with equivalents without departing from the scope of this application. In particular, the technical features mentioned in the various embodiments can be combined in any manner, provided there is no structural conflict. This application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A nitrogen-filling sealing device, characterized in that, include: Base, the base supporting the vial; A protective shell is disposed above the base. The protective shell is configured to cover the outside of the vial and form a receiving space inside the protective shell. The protective shell has a through hole configured to receive a protective gas filled into the receiving space so that the vial can contain the protective gas. as well as A first lifting mechanism is connected to the protective shell, and the first lifting mechanism drives the protective shell to move relative to the base in a vertical direction; An adsorption and clamping component is disposed inside the protective shell and is movably disposed in the vertical direction. The adsorption and clamping component is configured to pick up the stopper of the vial and clamp the mouth of the vial to realize the opening and closing of the mouth of the vial.

2. The nitrogen-filling sealing device according to claim 1, characterized in that, The adsorption and pressing component includes a body and a first ventilation channel formed by the body. The end face of the body near the base includes a recess and a protrusion around the recess. The first ventilation channel is configured to control the recess depth of the recess under different air pressures to achieve adsorption and pressing of the vial stopper.

3. The nitrogen-filling sealing device according to claim 1, characterized in that, The protective shell includes a top wall and a side wall, the side wall being connected to the top wall, and the through hole being disposed on the side wall, the through hole being located above the mouth of the vial in the vertical direction.

4. The nitrogen-filling sealing device according to claim 2, characterized in that, The protective shell has a first opening at the top, and the nitrogen filling and sealing device includes a second lifting mechanism, which includes a top rod. One end of the top rod near the base is connected to the adsorption and pressing member, which drives the adsorption and pressing member to move in the vertical direction. The top rod passes through the first opening.

5. The nitrogen-filling sealing device according to claim 4, characterized in that, The second lifting mechanism also includes a sealing element, which is sleeved on the outside of the top rod and disposed at the first opening to seal the first opening; the top rod is movably disposed in the vertical direction to drive the adsorption and pressing element to press the vial stopper.

6. The nitrogen-filling sealing device according to claim 4, characterized in that, The top rod includes a second ventilation channel disposed inside, which is connected to the first ventilation channel; the nitrogen filling and sealing device includes an air pump and an air filling pipe connected to the air pump, which is configured to introduce gas into the second ventilation channel.

7. The nitrogen-filling sealing device according to claim 1, characterized in that, The nitrogen-filling sealing device includes a movable component connected to the base, which moves the base.

8. The nitrogen-filling sealing device according to claim 3, characterized in that, The protective shell is provided with a second opening, which is arranged vertically opposite to the top wall, and the second opening divides the protective shell into a first protective shell and a second protective shell.

9. The nitrogen-filling sealing device according to claim 1, characterized in that, The protective shell includes a third opening facing the base, and the base seals the third opening so that the protective shell forms the receiving space.

10. The nitrogen-filling sealing device according to claim 4, characterized in that, The nitrogen-filling sealing device includes: a support rod disposed on one side of the protective shell; and one end of the second lifting mechanism connected to the support rod.

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