A detection device for macrophage pyroptosis

Abstract

This utility model discloses a pyroptosis detection device, including a detection box, and the detection box is provided with two sets; the bottom of the detection box is provided with a support plate, and the bottom of the support plate is equipped with an adjustment component for conveying and adjusting. The top of the adjustment component is provided with a display component for displaying detection data. The adjustment component includes a telescopic cylinder, which is located below the support plate. The output end of the telescopic cylinder is connected to a movable frame, and the top of the movable frame is provided with a support plate. The front end of the support plate is located at the top of the support plate, and guide rails are fixedly connected to both sides of the top of the support plate. This utility model avoids the inconvenience of operation or detection error caused by fixed height limitation, and the detection box can be adjusted to a comfortable height according to the user's operating habits, reducing bending over, tiptoeing and other actions, reducing fatigue from long-term operation, improving work efficiency, and avoiding spillage caused by improper operating posture during sample transfer.

Description

Technical Field

[0001] This invention relates to the field of pyroptosis detection technology, and in particular to a detection device for macrophage pyroptosis. Background Technology

[0002] Pyroptosis is a programmed cell death process closely related to various physiological and pathological processes. As important immune cells, macrophages can trigger pyroptosis by activating inflammasomes when they encounter pathogen-associated molecular patterns, releasing inflammatory factors and playing an important role in innate immunity. Studying macrophage pyroptosis is of great significance for understanding the mechanism of immune cell activation, the immune response triggered by pathogen infection, and exploring the pathogenesis and treatment strategies of diseases such as nervous system diseases and tumors.

[0003] Most existing pyroptosis detection devices have relatively fixed detection positions, requiring manual height adjustment. This makes it difficult to achieve continuous and precise height changes, which is hard to quickly match different detection scenarios. Furthermore, the adjustment process may require machine shutdown, interrupting the detection process and reducing experimental efficiency. At the same time, it is difficult to adapt to the usage habits of different operators, and long-term use may increase operator fatigue, indirectly affecting detection accuracy.

[0004] Therefore, in view of the fact that most of the above-mentioned pyroptosis detection devices have relatively fixed detection positions, cannot achieve continuous and precise high-precision changes, are difficult to quickly match different detection scenarios, and reduce experimental efficiency, a detection device for macrophage pyroptosis can be designed. Utility Model Content

[0005] To overcome the problem that most pyroptosis detection devices have relatively fixed detection positions, making it impossible to achieve continuous and precise high-precision changes, and making it difficult to quickly match different detection scenarios, thus reducing experimental efficiency, a detection device for macrophage pyroptosis is proposed.

[0006] The technical solution of this utility model is as follows: a detection device for macrophage pyroptosis, including a detection box, and the detection box is provided with two sets; a support plate is provided at the bottom of the detection box, and an adjustment component for conveying adjustment is installed at the bottom of the support plate. A display component for displaying detection data is provided at the top of the adjustment component. The adjustment component includes a telescopic cylinder, which is located below the support plate. The output end of the telescopic cylinder is connected to a movable frame. A support plate is provided at the top of the movable frame, and the front end of the support plate is located at the top of the support plate. Guide rails are fixedly connected to both sides of the top of the support plate.

[0007] Preferably, a connecting plate is slidably connected to the top of the guide rail, and sliding blocks are fixedly connected to both sides of the bottom of the connecting plate. The sliding blocks are slidably connected to the outside of the guide rail. The sliding blocks are locked to the guide rail by a threaded button, and the threaded button passes through the side wall of the sliding block and presses against the side of the guide rail to achieve locking. A bracket is provided on the outside of the support plate.

[0008] Preferably, the front end of the support plate has a through hole, the outside of the bracket is bolted with a support frame, and the telescopic cylinder is installed between the support frames.

[0009] Preferably, casters are installed at the four corners of the bottom of the support frame, and support blocks are provided on the opposite side of each caster. A control box is provided on the rear side of the top of the support frame.

[0010] Preferably, a rear plate is installed on the rear side of the testing box, and a mounting bracket is installed on the rear side of the rear plate, with the mounting bracket mounted on a support frame.

[0011] Preferably, the display component includes a mounting base disposed at the top of a support frame, a movable seat mounted at the top of the support frame, and a mounting plate disposed at the front end of the movable seat.

[0012] Preferably, a heat sink is mounted on the front end of the mounting plate, a display screen is mounted on the front end of the heat sink, and rotating brackets are provided on both sides of the rear end of the display screen, with the rotating brackets and the heat sink being rotatably connected by a connecting rod.

[0013] The beneficial effects of this utility model are as follows: When the telescopic cylinder is activated, the output end of the telescopic cylinder pushes the movable frame to move up and down, which drives the support plate and the detection box to rise and fall synchronously, adjusting the height of the detection box to adapt to different detection needs. This avoids the inconvenience or detection error caused by fixed height limitations. Moreover, the detection box can be adjusted to a comfortable height according to one's own operating habits, reducing bending over, tiptoeing and other actions, reducing fatigue from long-term operation, improving work efficiency, and avoiding the risk of spillage and contamination caused by improper operating posture during sample transfer, thus ensuring experimental safety. Attached Figure Description

[0014] Figure 1 The diagram shown is a first three-dimensional structural schematic of this utility model;

[0015] Figure 2 The diagram shown is a second three-dimensional structural schematic of this utility model;

[0016] Figure 3 The diagram shown is a bottom-view perspective view of the structure of this utility model.

[0017] Figure 4 The diagram shown is a three-dimensional structural schematic of the display component and adjustment component of this utility model;

[0018] Figure 5The diagram shown is a partial three-dimensional structural schematic of the display component of this utility model.

[0019] Explanation of reference numerals in the attached drawings: 1. Detection box; 2. Support plate; 3. Rear plate; 4. Mounting frame; 501. Telescopic cylinder; 502. Movable frame; 503. Support plate; 504. Guide rail; 505. Connecting plate; 506. Sliding block; 507. Bracket; 508. Through hole; 509. Support frame; 510. Caster wheel; 511. Support block; 512. Control box; 601. Mounting seat; 602. Movable seat; 603. Mounting plate; 604. Heat sink; 605. Display screen; 606. Rotating frame. Detailed Implementation

[0020] Please see Figures 1-5 This utility model provides an embodiment: a detection device for macrophage pyroptosis, including a detection box 1, and the detection box 1 is provided with two sets; a support plate 2 is provided at the bottom of the detection box 1, and an adjustment component for conveying adjustment is installed at the bottom of the support plate 2. A display component for displaying detection data is provided at the top of the adjustment component. The adjustment component includes a telescopic cylinder 501, which is located below the support plate 2. The output end of the telescopic cylinder 501 is connected to a movable frame 502. A support plate 503 is provided at the top of the movable frame 502, and the front end of the support plate 503 is located at the top of the support plate 2. Guide rails 504 are fixedly connected to both sides of the top of the support plate 503; a rear plate 3 is installed on the rear side of the detection box 1, and a mounting frame 4 is installed on the rear side of the rear plate 3. The mounting frame 4 is installed on the support frame 509.

[0021] Please see Figures 2-4 In this embodiment, a connecting plate 505 is slidably connected to the top of the guide rail 504, and sliding blocks 506 are fixedly connected to both sides of the bottom end of the connecting plate 505. The sliding blocks 506 are slidably connected to the outside of the guide rail 504. The sliding blocks 506 are locked to the guide rail 504 by threaded buttons, and the threaded buttons penetrate the side wall of the sliding blocks 506 and press against the side of the guide rail 504 to achieve locking. A bracket 507 is provided on the outside of the support plate 503. A through hole 508 is opened in the front end of the support plate 503. A support frame 509 is installed on the outside of the bracket 507 by bolts, and a telescopic cylinder 501 is installed between the support frames 509. Universal wheels 510 are installed at the four corners of the bottom end of the support frame 509. A support block 511 is provided on the opposite side of the universal wheels 510. A control box 512 is provided on the rear side of the top end of the support frame 509.

[0022] The guide rail 504 and the connecting plate 505 are slidably connected by the sliding block 506 and can be fixed by the locking button, facilitating the adjustment of the position of the connecting plate 505 and related components. This adapts to the positional requirements of different sample sizes or different testing steps. The bracket 507 and the support frame 509 are bolted together, allowing for disassembly and assembly of the structure, facilitating adjustments to the overall layout according to the testing scenario. The air cylinder 501 is installed between the support frames 509, enabling automated lifting and lowering of related testing components, reducing human error, and is particularly suitable for high-throughput testing of batch samples. The casters 510 at the bottom of the support frame 509 further facilitate... The device can be moved as a whole, allowing for flexible switching of the testing environment; the support block 511 facing away from the device provides stable support when fixed, preventing the device from shaking during testing and affecting the accuracy of the results; the sliding block 506 is locked by a locking button to ensure that the position is fixed after adjustment, preventing sample contamination or test data deviation caused by component sliding during testing; the through hole 508 at the front end of the support plate 503 may be used for wiring or sample positioning, keeping the internal structure of the device neat and reducing the risk of failure caused by messy wiring; the control box 512 integrates control functions, facilitating unified control of cylinder actions, position locking, etc., and improving operational safety.

[0023] Please see Figure 5 In this embodiment, the display component includes a mounting base 601, which is disposed at the top of the support frame 509. A movable base 602 is mounted at the top of the support frame 509, and a mounting plate 603 is disposed at the front end of the movable base 602. A heat sink 604 is mounted at the front end of the mounting plate 603, and a display screen 605 is mounted at the front end of the heat sink 604. Rotating frames 606 are disposed on both sides of the rear end of the display screen 605, and the rotating frames 606 and the heat sink 604 are rotatably connected by a connecting rod.

[0024] The cooperation between the movable base 602 and the mounting base 601, and the rotational connection between the rotating frame 606 and the heat sink 604 via a connecting rod, allows the display screen 605 to flexibly adjust its angle and position. Inspectors can easily adjust the display screen 605 to the optimal viewing state according to their operating habits, observation needs, or ambient lighting conditions, improving operational convenience. The heat sink 604, directly installed between the mounting plate 603 and the display screen 605, efficiently absorbs and dissipates the heat generated by the display screen 605 during operation, preventing the display screen 605 from experiencing performance instability or shortening its lifespan due to excessively high operating temperatures over a long period. This ensures the continuity and accuracy of data display during testing. The mounting base 601, fixed to the top of the support frame 509, provides a stable support foundation for the entire display assembly. The sequential connection structure of components such as the mounting plate 603 and the heat sink 604 further enhances the overall stability of the display assembly, reducing the risk of displacement or damage to the display screen 605 due to equipment vibration or collision during the experiment, ensuring the smooth progress of the testing work.

[0025] The device is pushed to the experimental area using the casters 510 at the bottom of the support frame 509, ensuring that the detection box 1 is in a horizontal and stable environment. The support block 511 is adjusted to contact the ground. The cooperation between the support block 511 and the casters 510 secures the device and prevents displacement during the detection process, thus achieving stable fixation of the device. According to the detection requirements, the locking button on the sliding block 506 is released, and the connecting plate 505 is pushed to slide along the guide rail 504, causing the detection box 1 to move horizontally. The relative position of the sample and the detection module is adjusted until they are aligned with the detection area. After the adjustment is completed, the locking button is pressed to fix the sliding block 506 on the guide rail 504 to prevent positional deviation during detection. The telescopic cylinder 501 is activated through the control box 512. The output end of the telescopic cylinder pushes the movable frame 502 to move up and down, causing the support plate 503 and the detection box 1 to rise and fall synchronously, adjusting the detection... The height of the testing chamber 1 can be adapted to different testing needs. By rotating the rotating frame 606 at the rear of the rotating display screen 605, the display screen 605 is rotated around the heat sink 604 via a connecting rod. The tilt angle of the display screen 605 can be adjusted to ensure that the operator can clearly observe the data. If it is necessary to move the display screen 605 horizontally, the movable seat 602 can be pushed to slide along the mounting seat 601 to adjust the horizontal position of the display screen 605 at the top of the support frame 509. Open the testing chamber 1 and place the processed macrophage sample in the testing position inside the testing chamber 1. Close the testing chamber 1 to ensure the sealing of the testing environment. Operate the control box 512 to start the testing program of the testing device. The control box 512 will regulate the testing process inside the testing chamber 1. During the testing process, the display screen 605 will display the detection data of macrophage cell pyroptosis in real time. The operator can observe the testing situation through the display screen 605.

Claims

1. A detection device for macrophage pyroptosis, comprising a detection box (1), and the detection box (1) is provided with two groups; characterized in that: The bottom of the test box (1) is provided with a support plate (2). The bottom of the support plate (2) is equipped with an adjustment component for conveying adjustment. The top of the adjustment component is provided with a display component for displaying test data. The adjustment component includes a telescopic cylinder (501). The telescopic cylinder (501) is located below the support plate (2). The output end of the telescopic cylinder (501) is connected to a movable frame (502). The top of the movable frame (502) is provided with a support plate (503). The front end of the support plate (503) is located at the top of the support plate (2). Guide rails (504) are fixedly connected to both sides of the top of the support plate (503).

2. The detection device for macrophage pyroptosis according to claim 1, characterized in that: A connecting plate (505) is slidably connected to the top of the guide rail (504). Sliding blocks (506) are fixedly connected to both sides of the bottom end of the connecting plate (505). The sliding blocks (506) are slidably connected to the outside of the guide rail (504). The sliding blocks (506) are locked to the guide rail (504) by a threaded button. The threaded button passes through the side wall of the sliding block (506) and presses against the side of the guide rail (504) to achieve locking. A bracket (507) is provided on the outside of the support plate (503).

3. The detection device for macrophage pyroptosis according to claim 2, characterized in that: The front end of the support plate (503) has a through hole (508), and the support frame (509) is bolted to the outside of the bracket (507), and the telescopic cylinder (501) is installed between the support frames (509).

4. The detection device for macrophage pyroptosis according to claim 3, characterized in that: The four corners of the bottom of the support frame (509) are equipped with casters (510), and the opposite side of the casters (510) is provided with a support block (511). The rear side of the top of the support frame (509) is provided with a control box (512).

5. The detection device for macrophage pyroptosis according to claim 3, characterized in that: A rear plate (3) is installed on the rear side of the test box (1), and a mounting bracket (4) is installed on the rear side of the rear plate (3), and the mounting bracket (4) is installed on the support frame (509).

6. The detection device for macrophage pyroptosis according to claim 1, characterized in that: The display component includes a mounting base (601) which is located at the top of a support frame (509). A movable base (602) is mounted at the top of the support frame (509), and a mounting plate (603) is provided at the front end of the movable base (602).

7. The detection device for macrophage pyroptosis according to claim 6, characterized in that: A heat sink (604) is installed at the front end of the mounting plate (603), and a display screen (605) is installed at the front end of the heat sink (604). Rotating frames (606) are provided on both sides of the rear end of the display screen (605), and the rotating frames (606) and the heat sink (604) are rotatably connected by a connecting rod.

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