A decoloring device for pharmaceutical intermediate products

Abstract

The utility model discloses a medicine intermediate product decoloring device relates to medicine intermediate technical field, a medicine intermediate product decoloring device, including jar body, still include: seal cover, dismantle and connect on jar body, sleeve, rotation is connected on seal cover, piston disc, sliding connection is in sleeve, pivot, connect on piston disc, and can follow sleeve synchronous rotation, wherein, one end equal interval fixed connection of hollow pole has multigroup in jar body penetration of pivot, the utility model, hollow pole relies on jar body and rotates, reciprocating motion and airflow disturbance synergistic effect, let medicine intermediate and decoloring agent contact area increase greatly, compared with single stirring mode, contact more comprehensive, more frequently, effectively break the local concentration gradient of material, eliminate mixed dead angle, make decoloring reaction even, promote decoloring efficiency and effect, shorten decoloring time, guarantee product quality stability.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical intermediates technology, specifically, it relates to a decolorization device for pharmaceutical intermediate products. Background Technology

[0002] In the preparation process of pharmaceutical intermediates, decolorization is a crucial step in ensuring product quality. Pharmaceutical intermediates often introduce various pigment impurities during production, which not only affect the product's appearance but may also interfere with the progress and effectiveness of subsequent pharmaceutical synthesis reactions. Currently, activated carbon adsorption is widely used in industrial preparation for decolorization. The porous structure of activated carbon physically adsorbs pigment impurities to achieve product purification.

[0003] In this process, the mixing effect between the material and activated carbon directly determines the decolorization efficiency. Efficient mixing can increase the contact area, enhance the mass transfer process, and improve the decolorization quality.

[0004] However, most existing pharmaceutical intermediate decolorization devices rely solely on a single mechanical stirring structure, using a fixed blade to rotate and stir the material. This method makes it difficult to achieve thorough three-dimensional mixing of the material, and local concentration gradients easily form within the tank. This results in insufficient contact between activated carbon and pharmaceutical intermediates in some areas, creating mixing dead zones, which greatly limits the decolorization reaction efficiency, leading to long decolorization times, high reagent consumption, and poor product quality stability. Therefore, this utility model is proposed. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the shortcomings of the prior art and provide a decolorization device for pharmaceutical intermediate products that can overcome or at least partially solve the above problems.

[0006] To solve the above-mentioned technical problems, the basic concept of the technical solution adopted by this utility model is as follows:

[0007] A decolorization device for pharmaceutical intermediates includes a tank and further includes: a sealing cap detachably connected to the tank; a sleeve rotatably connected to the sealing cap; a piston disc slidably connected inside the sleeve; a rotating shaft connected to the piston disc and capable of rotating synchronously with the sleeve, wherein a plurality of hollow rods are fixedly connected at equal intervals to one end of the rotating shaft passing through the tank, and air jet holes are opened on the hollow rods; the shaft and the piston disc each have a hollow cavity communicating with the hollow rods; a spring disposed inside the sleeve, one end of which is fixedly connected to the lower end face of the piston disc, and the other end of which is fixedly connected to the inner wall of the sleeve; and an intermittent gas supply mechanism disposed on one side of the tank and used to intermittently supply gas to the hollow cavity.

[0008] In order to drive the sleeve to rotate, preferably, a motor is fixedly installed on the sealing cover, and gears that mesh with each other are fixedly installed on the output end of the motor and on the sleeve.

[0009] To enable the rotating shaft to rotate synchronously with the sleeve, a guide groove is further provided on the inner wall of the sleeve, and a protrusion is integrally formed on the outer wall of the piston disc, the protrusion being slidably connected in the guide groove.

[0010] Preferably, the intermittent gas supply mechanism includes a booster pump and a gas delivery pipe. The booster pump is located on one side of the tank. The gas delivery pipe is fixedly connected to the output end of the booster pump. The end of the gas delivery pipe away from the booster pump is connected to the inside of the sleeve through a rotary joint. The rotary joint is located on the sleeve.

[0011] Preferably, the hollow rod is an elastic rod, and a counterweight ball is fixedly connected to the end of the hollow rod away from the pivot.

[0012] To facilitate the assembly and disassembly of the tank, preferably, the sealing cap is detachably connected to the tank body using multiple fixing bolts.

[0013] In order to keep the internal pressure of the tank constant, preferably, the sealing cover is provided with a pressure relief pipe connected to the tank, and the pressure relief pipe is provided with a pressure relief valve.

[0014] To facilitate the discharge of the decolorized product from the tank, preferably, the bottom of the tank is fixedly connected to a discharge pipe, the inner wall of the bottom of the tank is conical, and a valve switch is provided on the discharge pipe.

[0015] To ensure the high purity of the product, the lower end of the discharge pipe is threadedly connected to a collection tank, and a filter plate is provided at the bottom of the collection tank.

[0016] By adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art:

[0017] In this invention, the hollow rod, through its rotation, reciprocating motion, and airflow disturbance within the tank, significantly increases the contact area between the pharmaceutical intermediate and the decolorizing agent. Compared to a single stirring method, this results in more comprehensive and frequent contact, effectively breaking down local concentration gradients in the materials, eliminating mixing dead zones, ensuring uniform decolorization reaction, improving decolorization efficiency and effectiveness, shortening decolorization time, and guaranteeing product quality stability. Attached Figure Description

[0018] Figure 1 This is a sectional view of the tank body of this utility model;

[0019] Figure 2 This is a schematic diagram of the structure of this utility model;

[0020] Figure 3 This is a partial structural schematic diagram of the present invention;

[0021] Figure 4 This is a utility model Figure 1 Enlarged view of section A;

[0022] Figure 5 This is a utility model Figure 3 Enlarged view of section B.

[0023] In the diagram: 1. Tank body; 101. Sealing cover; 102. Discharge pipe; 103. Collection tank; 104. Filter plate; 2. Sleeve; 201. Piston disc; 202. Rotating shaft; 203. Guide groove; 204. Hollow rod; 205. Counterweight ball; 206. Spring; 3. Hollow cavity; 301. Air jet hole; 302. Booster pump; 303. Gas supply pipe; 304. Pressure relief pipe; 4. Motor; 401. Gear. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. The following embodiments are used to illustrate this utility model, but are not intended to limit the scope of this utility model.

[0025] Example 1:

[0026] Reference Figure 1 , Figure 2 , Figure 3 , Figure 5 A decolorization device for pharmaceutical intermediates includes a tank 1, and further includes: a sealing cap 101, detachably connected to the tank 1; a sleeve 2, rotatably connected to the sealing cap 101; a piston disc 201, slidably connected inside the sleeve 2; a rotating shaft 202, connected to the piston disc 201 and capable of rotating synchronously with the sleeve 2, wherein one end of the rotating shaft 202, which passes through the tank 1, is equidistantly fixedly connected to multiple sets of hollow rods 204, each hollow rod 204 having an air jet hole 301; and both the rotating shaft 202 and the piston disc 201 having a hollow cavity 3 communicating with the hollow rods 204; a spring 206 disposed inside the sleeve 2, one end of which is fixedly connected to the lower end face of the piston disc 201, and the other end of which is fixedly connected to the inner wall of the sleeve 2; and an intermittent gas supply mechanism disposed on one side of the tank 1 and used to intermittently supply gas to the hollow cavity 3.

[0027] A motor 4 is fixedly installed on the sealing cover 101, and gears 401 that mesh with each other are fixedly installed on the output end of the motor 4 and on the sleeve 2.

[0028] The inner wall of the sleeve 2 is provided with a guide groove 203, and the outer wall of the piston disc 201 is integrally formed with a protrusion, which is slidably connected in the guide groove 203.

[0029] The intermittent gas supply mechanism includes a booster pump 302 and a gas delivery pipe 303. The booster pump 302 is located on one side of the tank 1. The gas delivery pipe 303 is fixedly connected to the output end of the booster pump 302. The end of the gas delivery pipe 303 away from the booster pump 302 is connected to the inside of the sleeve 2 through a rotary joint. The rotary joint is located on the sleeve 2.

[0030] When in use, the operator removes the sealing cap 101, adds pharmaceutical intermediate raw materials and decolorizing agent (such as activated carbon) into the tank 1, installs the sealing cap 101, starts the motor 4 and the booster pump 302, and prepares for the decolorization operation.

[0031] Start motor 4. Motor 4 drives sleeve 2 to rotate through gear 401. Sleeve 2 cooperates with the protrusion of piston disc 201 through guide groove 203, and synchronously drives rotating shaft 202 and hollow rod 204 to rotate, so as to stir the material in tank 1 and initially disrupt the material distribution.

[0032] The booster pump 302 starts at a set frequency and delivers high-pressure gas to the gas delivery pipe 303. The gas enters the sleeve 2 through the rotary joint, and then passes through the hollow cavity 3 of the piston disc 201 and the rotating shaft 202. It is then ejected from the jet hole 301 of the hollow rod 204, causing airflow disturbance to the material and further disrupting the original static distribution of the material.

[0033] When the gas pressure pushes the piston disc 201 downward, the spring 206 is compressed, and the rotating shaft 202 on it drives the hollow rod 204 to move downward synchronously in the tank 1. When the booster pump 302 intermittently stops supplying gas, the spring 206 rebounds, pushing the piston disc 201 to return to its original position. The rotating shaft 202 on it drives the hollow rod 204 to move upward synchronously in the tank 1 to return to its original position. This reciprocating motion allows the hollow rod 204 to cover different layers of materials in the tank 1, enhancing the mixing effect. As the sleeve 2 continues to rotate, the hollow rod 204, relying on the dual effects of rotation, reciprocating motion, and airflow disturbance in the tank 1, allows the pharmaceutical intermediate and the decolorizing agent to fully contact and react, achieving efficient decolorization until the required degree of decolorization is reached.

[0034] In summary, the hollow rod 204, through the combined effects of rotation, reciprocating motion, and airflow disturbance within the tank 1, significantly increases the contact area between the pharmaceutical intermediate and the decolorizing agent. Compared to a single stirring method, the contact is more comprehensive and frequent, effectively breaking down local concentration gradients in the materials, eliminating mixing dead zones, ensuring uniform decolorization reaction, improving decolorization efficiency and effectiveness, shortening decolorization time, and guaranteeing product quality stability.

[0035] It should be noted that the gas supply pipe 303 is equipped with a one-way valve and is a stretchable and retractable hose. Therefore, the gas supply pipe 303 will not interfere with the installation and removal of the sealing cap 101.

[0036] Example 2:

[0037] Reference Figure 4 A decolorization device for pharmaceutical intermediate products is basically the same as that in Example 1. Furthermore, the hollow rod 204 is an elastic rod, and a counterweight ball 205 is fixedly connected to the end of the hollow rod 204 away from the rotating shaft 202.

[0038] When the rotating shaft 202 drives the hollow rod 204 to rotate, due to the elasticity of the hollow rod 204 and the centrifugal force of the counterweight ball 205, the hollow rod 204 will produce elastic swinging and vibration. When the intermittent air supply mechanism sprays air, the airflow is ejected from the air jet hole 301. Combined with the elastic deformation and vibration of the hollow rod 204, it further disturbs the material. Moreover, the dynamic deformation of the elastic rod under the rotation and airflow impact can adapt to materials in different positions and different flow states, enhance the mixing effect, promote the contact and reaction between the material and the decolorizing agent, and improve the decolorization reaction rate and effect.

[0039] Example 3:

[0040] Reference Figure 1 , Figure 2 , Figure 4 A decolorization device for a pharmaceutical intermediate product is basically the same as that in Example 1, except that the sealing cap 101 is detachably connected to the tank 1 by multiple fixing bolts.

[0041] When pharmaceutical intermediate raw materials or decolorizing agents (such as activated carbon) need to be added into tank 1, the operator loosens the fixing bolts, removes the sealing cap 101, and adds the materials into the tank 1 as needed through the top opening of tank 1. During this process, the removable sealing cap 101 provides an unobstructed large opening for material addition, which facilitates quick and accurate material addition by the operator and avoids material spillage. After the addition is completed, the sealing cap 101 is closed again, the bolts are inserted and tightened to restore the sealing state of tank 1 and enter the decolorization process.

[0042] After the decolorization operation is completed, if it is necessary to clean the inside of tank 1, the operator loosens the fixing bolts again and removes the sealing cover 101. At this time, the top of tank 1 is completely open, and the operator can directly insert cleaning tools (such as brushes, high-pressure water guns, etc.) into the inside of tank 1 to thoroughly clean the residual materials and impurities adsorbed on the tank wall. After cleaning, the sealing cover 101 and tank 1 are reassembled according to the installation procedure to prepare for the next decolorization operation.

[0043] The sealing cover 101 is provided with a pressure relief pipe 304 that is connected to the tank body 1, and a pressure relief valve is provided on the pressure relief pipe 304;

[0044] When the pressure inside tank 1 exceeds the pressure relief valve's set value due to intermittent gas supply, material reaction, or other factors, the pressure relief valve automatically opens. At this time, the gas inside tank 1 is discharged through the pressure relief pipe 304, and the pressure decreases. When the pressure drops to the set closing pressure value, the pressure relief valve automatically closes, maintaining the pressure inside tank 1 within a safe and reasonable range. This prevents safety accidents such as tank 1 rupture and material splashing caused by overpressure, thus protecting the equipment and the safety of operators.

[0045] The bottom of the tank body 1 is fixedly connected to a discharge pipe 102. The inner wall of the bottom of the tank body 1 is conical. A valve switch is installed on the discharge pipe 102.

[0046] After decolorization is completed, open the valve switch on the discharge pipe 102. Due to the conical design of the inner wall at the bottom of the tank 1, the decolorized material gathers at the inlet of the discharge pipe 102 under the action of gravity and is smoothly discharged from the tank 1. The conical bottom and the design of the discharge pipe 102 allow the decolorized material to be discharged quickly and smoothly, avoiding material residue at the bottom of the tank and reducing material waste. After the discharge is completed, close the valve switch to prepare for the next decolorization operation.

[0047] The lower end of the discharge pipe 102 is threadedly connected to a collection tank 103, and a filter plate 104 is provided at the bottom of the collection tank 103;

[0048] When the valve on the discharge pipe 102 is opened, the decolorized material flows into the collection tank 103 through the discharge pipe 102. When the material flows in the collection tank 103, it first contacts the filter plate 104. The liquid product (the product after decolorization of pharmaceutical intermediates) can pass through the micropores on the filter plate 104 and be discharged from the outlet reserved at the bottom of the collection tank 103. Solid impurities (such as residual activated carbon, unreacted decolorizing agents, etc.) are intercepted by the filter plate 104 and remain above the filter plate 104. After the discharge is completed and the valve on the discharge pipe 102 is closed, the collection tank 103 can be unscrewed to clean the impurities on the filter plate 104, or the collection tank 103 can be replaced to continue collecting subsequent impurities.

[0049] The filter plate 104 can effectively intercept solid impurities in the material, making the collected pharmaceutical intermediate liquid products purer, avoiding the impact of impurities on subsequent pharmaceutical production processes (such as synthesis reactions, formulation preparation, etc.), improving product quality, reducing product defect rates caused by impurities, and ensuring the stability of pharmaceutical production.

[0050] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model.

Claims

1. A decolorization device for pharmaceutical intermediate products, comprising a tank (1), characterized in that, Also includes: A sealing cap (101) is detachably connected to the tank body (1); Sleeve (2) is rotatably connected to the sealing cover (101); Piston disc (201) is slidably connected inside the sleeve (2); A rotating shaft (202) is connected to the piston disc (201) and can rotate synchronously with the sleeve (2). The rotating shaft (202) has multiple sets of hollow rods (204) fixedly connected at equal intervals at one end of the shaft (202) that passes through the tank (1). The hollow rods (204) are provided with air jet holes (301). The shaft (202) and the piston disc (201) are both provided with hollow cavities (3) that communicate with the hollow rods (204). A spring (206) is installed inside the sleeve (2), one end of which is fixedly connected to the lower end face of the piston disc (201), and the other end is fixedly connected to the inner wall of the sleeve (2). An intermittent gas supply mechanism is provided on one side of the tank (1) and is used to intermittently supply gas into the hollow cavity (3).

2. The decolorization device for pharmaceutical intermediate products according to claim 1, characterized in that, A motor (4) is fixedly installed on the sealing cover (101), and gears (401) that mesh with each other are fixedly installed on the output end of the motor (4) and on the sleeve (2).

3. The decolorization device for pharmaceutical intermediate products according to claim 2, characterized in that, The inner wall of the sleeve (2) is provided with a guide groove (203), and the outer wall of the piston disc (201) is integrally formed with a protrusion, which is slidably connected in the guide groove (203).

4. The decolorization device for pharmaceutical intermediate products according to claim 1, characterized in that, The intermittent gas supply mechanism includes a booster pump (302) and a gas delivery pipe (303). The booster pump (302) is located on one side of the tank (1). The gas delivery pipe (303) is fixedly connected to the output end of the booster pump (302). The end of the gas delivery pipe (303) away from the booster pump (302) is connected to the inside of the sleeve (2) through a rotary joint. The rotary joint is located on the sleeve (2).

5. The decolorization device for pharmaceutical intermediate products according to claim 1, characterized in that, The hollow rod (204) is an elastic rod, and a counterweight ball (205) is fixedly connected to the end of the hollow rod (204) away from the pivot (202).

6. The decolorization device for pharmaceutical intermediate products according to claim 1, characterized in that, The sealing cap (101) is detachably connected to the tank body (1) by multiple fixing bolts.

7. The decolorization device for pharmaceutical intermediate products according to claim 1, characterized in that, The sealing cap (101) is provided with a pressure relief pipe (304) that communicates with the tank body (1), and the pressure relief pipe (304) is provided with a pressure relief valve.

8. The decolorization device for pharmaceutical intermediate products according to claim 1, characterized in that, The bottom of the tank (1) is fixedly connected to a discharge pipe (102), the inner wall of the bottom of the tank (1) is conical, and a valve switch is provided on the discharge pipe (102).

9. A decolorization device for pharmaceutical intermediate products according to claim 8, characterized in that, The lower end of the discharge pipe (102) is threadedly connected to a collection tank (103), and a filter plate (104) is provided at the bottom of the collection tank (103).

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