A reaction vessel for producing carcinoembryonic antigen reagent

Abstract

This utility model discloses a carcinoembryonic antigen (CEA) reagent production reactor, including a reactor body. A jacket is provided in the middle of the arc surface of the reactor body. A spiral tube is spirally wound between the inner wall of the jacket and the outer arc surface of the reactor body. A support is provided at the upper end of the reactor body. It also includes a mixing mechanism. The mixing mechanism includes a first sealed bearing, a T-shaped rotating cylinder, a rotating rod, stirring blades, a second sealed bearing, a rotating shaft, a support rod, and spiral blades. The top wall of the reactor body is rotatably connected to the T-shaped rotating cylinder via the first sealed bearing. The upper end of the T-shaped rotating cylinder is rotatably connected to the top wall of the support. A rotating rod is fixedly connected to the middle of the lower end of the T-shaped rotating cylinder. Uniformly distributed stirring blades are fixedly sleeved on the outer wall of the rotating rod. This CEA reagent production reactor, during the production of CEA reagent, forms radial and axial stirring through multiple axes, reducing the likelihood of dead zones and improving the uniformity of material stirring and mass transfer efficiency.

Description

Technical Field

[0001] This utility model relates to the field of carcinoembryonic antigen (CEA) reagent production technology, specifically to a carcinoembryonic antigen (CEA) reagent production reactor. Background Technology

[0002] Carcinoembryonic antigen (CEA) is a tumor marker widely used in clinical practice for the detection of gastrointestinal malignancies. CEA is a glycoprotein primarily found in extracts from colorectal cancer and is often present in colon cancer, pancreatic cancer, and other cancers. It is also a commonly used tumor marker in oncology, playing a crucial role in preoperative screening and postoperative assessment of cancer recurrence and metastasis. Elevated CEA levels are commonly seen in gastric cancer, colorectal cancer, non-small cell lung cancer, pancreatic cancer, and breast cancer. However, some benign diseases, such as rectal polyps, cirrhosis, and ulcerative colitis, may also present with elevated CEA levels. The production of CEA reagents typically involves biochemical or immunological reactions, and the design of the reaction vessel must meet the requirements of high precision, sterility, and a controlled environment.

[0003] In some existing carcinoembryonic antigen (CEA) reagent production reactors, the raw materials for CEA reagent are poured into the reactor during production. Then, a stirring rod driven by a motor is used to mix and stir the raw materials in the reactor. While mixing, the reactor body is heated by a heating wire. The reactor body transfers heat to the raw materials inside the reactor, thereby completing the production reaction.

[0004] Existing carcinoembryonic antigen (CEA) reagent production reactors have the following problems: When producing CEA reagents, the centrifugal force or thrust generated by the rotation of a single stirring paddle causes the material to form a circular motion or axial convection within the reactor. The mixing area is limited, and dead zones are easily formed at the edges or bottom of the material, resulting in poor mixing uniformity. To address this, we propose a new CEA reagent production reactor. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the existing defects and provide a carcinoembryonic antigen (CEA) reagent production reactor. When producing CEA reagent, the reactor forms radial and axial stirring through multi-axis stirring, which makes it less likely to have stirring dead zones, improves the uniformity of material stirring and mass transfer efficiency, and can effectively solve the problems in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a carcinoembryonic antigen reagent production reactor, comprising a reactor body, a jacket provided in the middle of the arc surface of the reactor body, a spiral tube spirally wound between the inner wall of the jacket and the outer arc surface of the reactor body, a support provided at the upper end of the reactor body, and a mixing mechanism;

[0007] The mixing mechanism includes a first sealed bearing, a T-shaped rotating cylinder, a rotating rod, stirring blades, a second sealed bearing, a rotating shaft, support rods, and spiral blades. The top wall of the vessel is rotatably connected to the T-shaped rotating cylinder via the first sealed bearing. The upper end of the T-shaped rotating cylinder is rotatably connected to the top wall of the support. A rotating rod is fixedly connected to the middle of the lower end of the T-shaped rotating cylinder. Stirring blades are uniformly distributed and fixedly fitted on the outer wall of the rotating rod. Rotating shafts are rotatably connected to the left and right sides of the outer wall of the T-shaped rotating cylinder via the second sealed bearing. Symmetrical support rods are fixedly fitted on the outer walls of the rotating shafts. Spiral blades are fixedly connected between the inner sides of two vertically adjacent support rods. During the production of carcinoembryonic antigen reagent, radial and axial stirring is formed through multiple axes, which reduces the occurrence of stirring dead zones and improves the uniformity of material stirring and mass transfer efficiency.

[0008] Furthermore, a microcontroller is installed on the outside of the vessel body. The input terminal of the microcontroller is electrically connected to an external power source to provide electrical connections for various electrical appliances.

[0009] Furthermore, the mixing mechanism also includes a drive assembly, which includes a bevel gear one, a rotating column, a bevel gear two, a bevel gear three, a bevel gear four, and a rotating shaft. The upper end of the rotating shaft is fixedly connected to bevel gear one. The rotating column is rotatably connected between the left and right inner walls of the T-shaped rotating cylinder. Bevel gear two is fixedly sleeved on the left and right sides of the outer wall of the rotating column. Bevel gear one meshes with the vertically adjacent bevel gear two. Bevel gear three is fixedly sleeved in the middle of the rotating column. The center of the top wall of the support is fixedly connected to the rotating shaft. The lower end of the rotating shaft is fixedly connected to bevel gear four. Bevel gear three meshes with bevel gear four to provide a rotatable connection.

[0010] Furthermore, the drive assembly also includes gear one, gear two, and a motor. Gear one is fixedly sleeved on the upper side of the outer wall of the T-shaped rotating cylinder, and a motor is provided at the upper end of the bracket. Gear two is fixedly connected to the lower end of the output shaft of the motor. Gear one and gear two are meshed and connected. The input end of the motor is electrically connected to the output end of the microcontroller to provide rotation drive.

[0011] Furthermore, a pH sensor is provided in the middle of the outer arc surface of the jacket. The detection end of the pH sensor extends into the interior of the vessel. The pH sensor is bidirectionally electrically connected to the microcontroller, which facilitates pH value monitoring.

[0012] Furthermore, a pressure sensor is provided on the rear side of the upper end of the vessel body, with the probe end of the pressure sensor extending into the interior of the vessel body. A pressure relief valve is provided at the vent at the upper end of the vessel body. The pressure sensor is bidirectionally electrically connected to the microcontroller, and the input end of the pressure relief valve is electrically connected to the output end of the microcontroller to provide pressure monitoring.

[0013] Furthermore, a temperature sensor is provided on the front side of the upper end of the vessel body. The probe end of the temperature sensor extends into the interior of the vessel body. The temperature sensor is bidirectionally electrically connected to the microcontroller to provide temperature monitoring.

[0014] Furthermore, a feed pipe is provided at the feed inlet at the upper end of the vessel body, and a discharge pipe is provided at the discharge outlet at the lower end of the vessel body. A solenoid valve is connected in series at the upper end of the discharge pipe, and the input end of the solenoid valve is electrically connected to the output end of the microcontroller to facilitate feeding and discharging.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows: This carcinoembryonic antigen reagent production reactor has the following advantages:

[0016] Driven by a motor, the T-shaped rotating cylinder, through gear two and meshing gear one, rotates the rotating rod and stirring blades under the connection of sealed bearing one, mixing the central area inside the vessel and achieving radial mixing. Simultaneously, the rotating cylinder, through a rotating shaft, bevel gear three and meshing bevel gear four, drives the rotating shaft through meshing bevel gear two and meshing bevel gear one, rotating the support rod and spiral blades under the connection of sealed bearing two. The rotation of the spiral blades generates axial thrust, causing the material to circulate up and down along the vessel, thus achieving axial mixing. The combination of radial mixing by the stirring blades and axial circulation by the spiral blades improves the uniformity of material dispersion and mass transfer efficiency. This is suitable for the precision mixing requirements in the production of carcinoembryonic antigen reagents. During the production of carcinoembryonic antigen reagents, the multi-axis radial and axial mixing reduces the likelihood of dead zones in the mixing process, improving the uniformity of material mixing and mass transfer efficiency. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of this utility model;

[0018] Figure 2 This is a schematic diagram of the right side structure of this utility model;

[0019] Figure 3 This is a cross-sectional structural diagram of the present invention;

[0020] Figure 4 This is a schematic diagram of the internal cross-sectional structure of the vessel body of this utility model;

[0021] Figure 5 This is an enlarged structural diagram of point A in this utility model.

[0022] In the diagram: 1. Reactor body, 2. Spiral tube, 3. Outer shell, 4. pH sensor, 5. Pressure sensor, 6. Pressure relief valve, 7. Temperature sensor, 8. Support, 9. Mixing mechanism, 91. Sealed bearing I, 92. T-shaped rotating cylinder, 93. Rotating rod, 94. Stirring blade, 95. Sealed bearing II, 96. Rotating shaft, 97. Support rod, 98. Spiral blade, 99. Drive assembly, 991. Bevel gear I, 992. Rotating column, 993. Bevel gear II, 994. Bevel gear III, 995. Bevel gear IV, 996. Rotating shaft, 997. Gear I, 998. Gear II, 999. Motor, 10. Discharge pipe, 11. Solenoid valve, 12. Microcontroller, 13. Feed pipe. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figure 1-5 This embodiment provides a technical solution: a carcinoembryonic antigen reagent production reactor, including a reactor body 1, a jacket 3 located in the middle of the arc surface of the reactor body 1, a spiral tube 2 spirally wound between the inner wall of the jacket 3 and the outer arc surface of the reactor body 1, a support 8 located at the upper end of the reactor body 1, and a mixing mechanism 9. A microcontroller 12 is located outside the reactor body 1, and the input terminal of the microcontroller 12 is electrically connected to an external power source. A pH sensor 4 is located in the middle of the outer arc surface of the jacket 3, and the detection end of the pH sensor 4 extends into the interior of the reactor body 1. The pH sensor 4 and the microcontroller 12 are connected. A pressure sensor 5 is installed on the rear side of the upper end of the vessel body 1, with its probe extending into the interior of the vessel body 1. A pressure relief valve 6 is installed at the vent at the upper end of the vessel body 1. The pressure sensor 5 is bidirectionally electrically connected to the microcontroller 12, and the input end of the pressure relief valve 6 is electrically connected to the output end of the microcontroller 12. A temperature sensor 7 is installed on the front side of the upper end of the vessel body 1, with its probe extending into the interior of the vessel body 1. The temperature sensor 7 is bidirectionally electrically connected to the microcontroller 12. A feed pipe 13 is installed at the feed inlet at the upper end of the vessel body 1, and a discharge pipe 13 is installed at the lower end of the vessel body 1. A discharge pipe 10 is provided at the outlet, and a solenoid valve 11 is connected in series at the upper end of the discharge pipe 10. The input end of the solenoid valve 11 is electrically connected to the output end of the microcontroller 12. During the stirring and mixing process, the water inlet at the upper end of the spiral tube 2 is connected to an external heating or cooling medium such as hot water, steam, or coolant. When the temperature sensor 7 detects that the temperature inside the vessel deviates from the set value, the data is transmitted to the microcontroller 12. The microcontroller 12 controls the medium flow rate or temperature of the spiral tube 2, and heats or cools the vessel body 1 through heat conduction to maintain a stable reaction temperature. The pH sensor 4 is used for... The pH value of the material inside the reactor is monitored in real time and transmitted to the microcontroller 12. If the pH value deviates from the set range, the microcontroller 12 can control the external feeding device to add a regulator through the feed pipe 13 until the pH value returns to the target range. The pressure sensor 5 will monitor the gas pressure inside the reactor in real time. When the pressure exceeds the threshold, the microcontroller 12 will trigger the pressure relief valve 6 to open and release excess gas to prevent the reactor body 1 from being dangerous due to excessive pressure. After the reaction, the solenoid valve 11 will be opened through the control of the microcontroller 12, and the carcinoembryonic antigen reagent inside the reactor body 1 will be discharged from the discharge pipe 10.

[0025] Mixing mechanism 9 includes a first sealed bearing 91, a T-shaped rotating cylinder 92, a rotating rod 93, stirring blades 94, a second sealed bearing 95, a rotating shaft 96, a support rod 97, and spiral blades 98. The top wall of the vessel body 1 is rotatably connected to the T-shaped rotating cylinder 92 via the first sealed bearing 91. The upper end of the T-shaped rotating cylinder 92 is rotatably connected to the top wall of the support 8. The middle of the lower end of the T-shaped rotating cylinder 92 is fixedly connected to the rotating rod 93. The outer wall of the rotating rod 93 is fixedly fitted with evenly distributed stirring blades 94. The left and right sides of the outer wall of the T-shaped rotating cylinder 92 are respectively rotatably connected to the rotating shaft 96 via the second sealed bearing 95. The outer walls of the rotating shaft 97 are respectively fixedly fitted with the rotating shaft 96. The mixing mechanism 9 is equipped with symmetrical support rods 97. Spiral blades 98 are fixedly connected between the inner sides of two vertically adjacent support rods 97. The mixing mechanism 9 also includes a drive assembly 99, which comprises a bevel gear 991, a rotating column 992, a bevel gear 993, a bevel gear 994, a bevel gear 995, and a rotating shaft 996. The upper end of the rotating shaft 96 is fixedly connected to the bevel gear 991. The rotating column 992 is rotatably connected between the left and right inner walls of the T-shaped rotating cylinder 92. Bevel gears 993 are fixedly fitted on the left and right sides of the outer wall of the rotating column 992. The bevel gears 991 are respectively connected to the vertically adjacent bevel gears 993. The rotating column 992 is fixedly fitted with a bevel gear 994 in the middle. A rotating shaft 996 is fixedly connected to the center of the top wall of the support 8. A bevel gear 995 is fixedly connected to the lower end of the rotating shaft 996. Bevel gears 994 and 995 mesh with each other. The drive assembly 99 also includes a gear 997, a gear 998, and a motor 999. Gear 997 is fixedly fitted to the upper side of the outer wall of the T-shaped rotating cylinder 92. A motor 999 is located at the upper end of the support 8. Gear 998 is fixedly connected to the lower end of the output shaft of the motor 999. Gear 997 and 998 mesh with each other. The input of the motor 999... The output terminal of the microcontroller 12 is electrically connected. During the production of carcinoembryonic antigen (CEA) reagent, the CEA reagent material is injected into the vessel 1 through the feed pipe 13. Then, the microcontroller 12 controls the operation of motor 999. The output shaft of motor 999 drives gear 2 998 to rotate. Gear 2 998, through meshing gear 1 997, drives T-shaped rotating cylinder 92 to rotate around the axis of vessel 1 under the rotation of sealed bearing 1 91. The rotation of T-shaped rotating cylinder 92 drives rotating rod 93 to rotate. The rotation of rotating rod 93 drives stirring blade 94 to rotate, stirring and mixing the CEA reagent material in the central area inside vessel 1. Then, when T... While the T-shaped rotating cylinder 92 rotates, the rotating column 992 inside the T-shaped rotating cylinder 92 is driven to rotate by the rotating shaft 996 through the meshing of bevel gear three 994 and bevel gear four 995. The rotation of the rotating column 992 will cause the meshing bevel gear two 993 to mesh with the bevel gear one 991 at the upper end of the rotating shaft 96, driving the rotating shafts 96 on both sides to rotate under the rotation of the sealed bearing two 95. The rotating shaft 96 drives the support rod 97 and the spiral blade 98 to rotate. The spiral blade 98 is spiral in shape and generates axial thrust when rotating.The material circulates vertically along the vessel body 1, and the radial mixing of the stirring blades 94 combined with the axial circulation of the spiral blades 98 improves the uniformity of material dispersion and mass transfer efficiency, making it suitable for the precision mixing requirements in the production of carcinoembryonic antigen reagents.

[0026] The working principle of the carcinoembryonic antigen (CEA) reagent production reactor provided by this utility model is as follows: During the production of CEA reagent, the CEA reagent material is injected into the reactor body 1 through the feed pipe 13. Then, the microcontroller 12 controls the operation of motor 999. The output shaft of motor 999 drives gear 2 998 to rotate. Gear 2 998, through meshing gear 1 997, drives T-shaped rotating cylinder 92 to rotate around the axis of reactor body 1 under the rotation of sealed bearing 1 91. The rotation of T-shaped rotating cylinder 92 drives rotating rod 93 to rotate, and the rotation of rotating rod 93 drives stirring blade 94 to rotate. The carcinoembryonic antigen reagent material in the central area inside the vessel body 1 is stirred and mixed. Then, while the T-shaped rotating cylinder 92 rotates, the rotating column 992 inside the T-shaped rotating cylinder 92 is driven to rotate by the rotating shaft 996 through the meshing of bevel gear three 994 and bevel gear four 995. The rotation of the rotating column 992 will mesh with the bevel gear one 991 at the upper end of the rotating shaft 96 through the meshing bevel gear two 993, driving the rotating shafts 96 on both sides to rotate under the rotation of the sealed bearing two 95. The rotating shaft 96 drives the support rod 97 and the spiral blade 98 to rotate. The spiral blade 98 is spiral in shape, and when it rotates, it generates... Axial thrust causes the material to circulate up and down along the vessel body 1. The radial mixing of the stirring blades 94 and the axial circulation of the spiral blades 98 combine to improve the uniformity of material dispersion and mass transfer efficiency. This is suitable for the precision mixing requirements in the production of carcinoembryonic antigen reagents. During the mixing process, the inlet at the upper end of the spiral tube 2 is connected to an external heating or cooling medium such as hot water, steam, or coolant. When the temperature sensor 7 detects that the temperature inside the vessel deviates from the set value, the data is transmitted to the microcontroller 12. The microcontroller 12 controls the medium flow rate or temperature of the spiral tube 2, heating or cooling the vessel body 1 through heat conduction. To maintain a stable reaction temperature, pH sensor 4 monitors the acidity and alkalinity of the material inside the reactor in real time, and transmits the data to microcontroller 12. If the pH value deviates from the set range, microcontroller 12 can control the external feeding device to add a regulator through feed pipe 13 until the pH value returns to the target range. Pressure sensor 5 monitors the gas pressure inside the reactor in real time. When the pressure exceeds the threshold, microcontroller 12 triggers the pressure relief valve 6 to open, releasing excess gas to prevent the reactor body 1 from being dangerous due to excessive pressure. After the reaction, the solenoid valve 11 will be opened through the control of microcontroller 12, and the carcinoembryonic antigen reagent inside the reactor body 1 will be discharged from the discharge pipe 10.

[0027] It is worth noting that the pH sensor 4, pressure sensor 5, pressure relief valve 6, temperature sensor 7, motor 999, and solenoid valve 11 disclosed in the above embodiments are as follows: pH sensor 4 can be PHG-2081; pressure sensor 5 PT124B-210; pressure relief valve 6 YAX-42X; temperature sensor 7 PT100; motor 999 Y90S-4; and solenoid valve 11 ZCS-15. The microcontroller 12 controls the operation of pH sensor 4, pressure sensor 5, pressure relief valve 6, temperature sensor 7, motor 999, and solenoid valve 11 using methods commonly used in the prior art.

[0028] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A reaction vessel for producing carcinoembryonic antigen reagent, comprising a vessel body (1), wherein a jacket (3) is provided in the middle of the arc surface of the vessel body (1), and a spiral tube (2) is spirally wound between the inner wall of the jacket (3) and the outer arc surface of the vessel body (1), and a support (8) is provided at the upper end of the vessel body (1), characterized in that: It also includes a hybrid mechanism (9); Mixing mechanism (9): It includes a first sealed bearing (91), a T-shaped rotating cylinder (92), a rotating rod (93), a stirring blade (94), a second sealed bearing (95), a rotating shaft (96), a support rod (97), and a spiral blade (98). The top wall of the vessel body (1) is rotatably connected to the T-shaped rotating cylinder (92) through the first sealed bearing (91). The upper end of the T-shaped rotating cylinder (92) is rotatably connected to the top wall of the support (8). The middle part of the lower end of the T-shaped rotating cylinder (92) is fixedly connected to the rotating rod (93). The outer wall of the rotating rod (93) is fixedly fitted with uniformly distributed stirring blades (94). The left and right sides of the outer wall of the T-shaped rotating cylinder (92) are respectively rotatably connected to the rotating shaft (96) through the second sealed bearing (95). The outer wall of the rotating shaft (96) is respectively fixedly fitted with symmetrical upper and lower support rods (97). The inner sides of two vertically adjacent support rods (97) are respectively fixedly connected with spiral blades (98).

2. The carcinoembryonic antigen reagent production reactor according to claim 1, characterized in that: The vessel body (1) is equipped with a microcontroller (12) on its exterior, and the input terminal of the microcontroller (12) is electrically connected to an external power source.

3. The carcinoembryonic antigen reagent production reactor according to claim 2, characterized in that: The mixing mechanism (9) further includes a drive assembly (99), which includes a bevel gear one (991), a rotating column (992), a bevel gear two (993), a bevel gear three (994), a bevel gear four (995), and a rotating shaft (996). The upper end of the rotating shaft (96) is fixedly connected to the bevel gear one (991). The rotating column (992) is rotatably connected between the left and right inner walls of the T-shaped rotating cylinder (92). The left and right sides of the outer wall of the rotating column (992) are fixedly sleeved with bevel gear two (993). The bevel gear one (991) is meshed with the vertically adjacent bevel gear two (993). The middle part of the rotating column (992) is fixedly sleeved with bevel gear three (994). The center of the top wall of the support (8) is fixedly connected to the rotating shaft (996). The lower end of the rotating shaft (996) is fixedly connected to the bevel gear four (995). The bevel gear three (994) and the bevel gear four (995) are meshed.

4. The carcinoembryonic antigen reagent production reactor according to claim 3, characterized in that: The drive assembly (99) also includes gear one (997), gear two (998) and motor (999). Gear one (997) is fixedly sleeved on the upper side of the outer wall of the T-shaped rotating cylinder (92). Motor (999) is provided at the upper end of the bracket (8). Gear two (998) is fixedly connected to the lower end of the output shaft of motor (999). Gear one (997) and gear two (998) are meshed and connected. The input end of motor (999) is electrically connected to the output end of microcontroller (12).

5. The carcinoembryonic antigen reagent production reactor according to claim 2, characterized in that: A pH sensor (4) is provided in the middle of the outer arc surface of the jacket (3). The detection end of the pH sensor (4) extends into the interior of the vessel body (1). The pH sensor (4) is bidirectionally electrically connected to the microcontroller (12).

6. The carcinoembryonic antigen reagent production reactor according to claim 2, characterized in that: A pressure sensor (5) is provided on the rear side of the upper end of the vessel body (1). The probe end of the pressure sensor (5) extends into the interior of the vessel body (1). A pressure relief valve (6) is provided at the air outlet of the upper end of the vessel body (1). The pressure sensor (5) is bidirectionally electrically connected to the microcontroller (12). The input end of the pressure relief valve (6) is electrically connected to the output end of the microcontroller (12).

7. The carcinoembryonic antigen reagent production reactor according to claim 2, characterized in that: A temperature sensor (7) is provided on the front side of the upper end of the vessel body (1). The probe end of the temperature sensor (7) extends into the interior of the vessel body (1). The temperature sensor (7) is bidirectionally electrically connected to the microcontroller (12).

8. The carcinoembryonic antigen reagent production reactor according to claim 2, characterized in that: The upper end of the vessel body (1) is provided with a feed pipe (13) at the feed inlet and a discharge pipe (10) at the discharge outlet at the lower end of the vessel body (1). The upper end of the discharge pipe (10) is connected in series with a solenoid valve (11), and the input end of the solenoid valve (11) is electrically connected to the output end of the microcontroller (12).

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