A detection device and a raman online detection device suitable for whole process
By embedding the probe of the online detection device into the self-circulating pipeline of the drug solution, the problem of drug solution waste was solved, drug solution circulation detection was realized, and detection efficiency and accuracy were improved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SICHUAN KELUN PHARMA CO LTD
- Filing Date
- 2025-04-25
- Publication Date
- 2026-06-02
AI Technical Summary
Existing PAT online detection systems consume a large amount of reagent when detecting the content of intermediate samples, and the probe needs to be cleaned after detection, resulting in waste of reagent.
By directly embedding the probe of the online detection device into the self-circulating pipeline of the drug solution, detection can be achieved during the circulation of the drug solution, avoiding the discharge of the drug solution. The circulation of the drug solution is used for rinsing to ensure the accuracy of the detection.
It enables testing to be completed without wasting reagents and allows for real-time monitoring of reagent content throughout the entire production process, improving testing efficiency and accuracy.
Smart Images
Figure CN224317522U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of online detection technology, and more specifically, to a detection device and an online detection device suitable for the entire Raman process. Background Technology
[0002] Currently, the PAT online detection system introduces the reagent solution from the preparation tank into the RECTER fine reactor through a pipe via an opening on the lower side of the preparation tank when detecting the content of intermediate samples. To eliminate residues from the previous sample and ensure detection accuracy, the system needs to be programmed to automatically rinse the RECTER fine reactor three times with the reagent solution to be tested before sample detection. Furthermore, to ensure probe accuracy after sample testing, the probe also needs to be soaked in the reagent solution after testing. Therefore, each batch of reagent solution consumes more than 2000 ml during the entire detection process, resulting in significant waste.
[0003] In view of the above, this application is hereby submitted. Utility Model Content
[0004] The technical problem this invention aims to solve is that existing photovoltaic panel angle measuring devices can only measure the angle of photovoltaic panels from a fixed position, lacking flexibility. The purpose is to provide a detection device and an online detection device suitable for the entire Raman process. By installing the probes of the online detection device into the pipeline, it can be directly implanted into the self-circulating pipeline of the pharmaceutical solution in the workshop preparation system. The detection process does not require the discharge of the pharmaceutical solution; the detection can be completed during the circulation of the pharmaceutical solution, thereby achieving the goal of not wasting intermediate pharmaceutical solution during the detection process. At the same time, it can also achieve process monitoring of the pharmaceutical solution content throughout the entire production process, and can obtain the content status of the entire production process in real time.
[0005] This utility model is achieved through the following technical solution:
[0006] In a first aspect, this utility model provides a detection device, including a five-way pipe, wherein the five-way pipe includes a straight horizontal pipe, the straight horizontal pipe being used for installation in a self-circulating pharmaceutical liquid pipeline in a production line; one end of the straight horizontal pipe is the inlet of the pharmaceutical liquid to be tested, and the other end is the outlet of the pharmaceutical liquid to be tested;
[0007] The straight horizontal tube has multiple openings, and an online detection probe is sealed and installed at each opening.
[0008] The detection device of this utility model can be directly installed on the self-circulating pipeline of the medicine solution in the workshop preparation system by inserting the probes of the online detection device into the pipeline. The detection process does not require the medicine solution to be discharged. The detection can be completed during the circulation of the medicine solution, thereby achieving the purpose of not wasting intermediate medicine solution in the detection process. At the same time, it can also achieve process monitoring of the medicine solution content throughout the entire production process and obtain the content status of the entire production process in real time.
[0009] In one specific implementation, the online detection probe includes two temperature probes and one Raman probe.
[0010] In one specific implementation, a bypass detection tube is installed at the opening, and the online detection probe is installed inside the bypass detection tube.
[0011] In one specific implementation, the outer end of the bypass detection tube is sealed to the online detection probe by a clamp, which improves the sealing performance of the probe and the bypass detection tube installation and ensures the normal use of the detection device.
[0012] In one specific implementation, the two ends of the straight horizontal tube are provided with installation joints.
[0013] Secondly, this utility model provides an online detection device suitable for the entire Raman process, including a drug preparation tank. The top and bottom of the drug preparation tank are connected by a drug liquid self-circulation pipeline. The detection device is installed on the drug liquid self-circulation pipeline, and the two ends of the straight horizontal pipe are respectively connected to the drug liquid self-circulation pipeline.
[0014] This invention relates to an online Raman spectroscopy system for the entire process. By directly embedding a probe-equipped pipe into a self-circulating pharmaceutical solution pipeline, the self-circulating solution continuously "flushes" the straight-through horizontal pipe during detection, keeping it synchronized with the pharmaceutical solution being tested. This improves detection accuracy and enables process monitoring of the pharmaceutical solution content throughout the entire production process, allowing for real-time acquisition of the content information. Furthermore, this online Raman spectroscopy system eliminates the need to draw the pharmaceutical solution out to the detection device for rinsing, significantly saving on cleaning solutions.
[0015] In one specific implementation, a non-detection pipe connected in parallel with the straight horizontal pipe is also installed on the self-circulating pipe of the medicine solution. Valves are installed at both ends of the non-detection pipe. This invention also includes a non-detection pipe connected in parallel to the straight horizontal pipe. When the probe needs maintenance or replacement, the valves on the non-detection pipe are opened, and the valves at both ends of the straight horizontal pipe are closed, allowing the medicine solution to circulate normally through the non-detection pipe.
[0016] In one specific implementation, a circulation pump is installed on the self-circulating pipeline of the medicine solution.
[0017] In a specific implementation, the online detection probe is an online Raman acquisition probe.
[0018] In one specific implementation, at least two detection devices are installed in parallel on the self-circulating pipeline of the medicine solution.
[0019] Compared with the prior art, this utility model has the following advantages and beneficial effects:
[0020] 1. The present invention provides a detection device and an online detection device suitable for the entire Raman process. By installing each probe of the online detection device into the pipeline, it can be directly implanted into the self-circulating pipeline of the drug solution in the workshop preparation system. The detection process does not require the drug solution to be discharged. The detection can be completed during the drug solution circulation process, thereby achieving the purpose of not wasting intermediate drug solution in the detection process.
[0021] 2. The detection device and the online detection device for the entire Raman process provided by this utility model embodiment can not only meet the requirement of completing the detection of intermediate samples without consumption, but also achieve process monitoring of the content of the drug solution in the entire production process, and can obtain the content status of the entire production process in real time. Attached Figure Description
[0022] To more clearly illustrate the technical solutions of the exemplary embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.
[0023] Figure 1 A schematic diagram of the five-way pipe structure provided in this embodiment of the utility model;
[0024] Figure 2 A schematic diagram of the detection device provided in an embodiment of this utility model;
[0025] Figure 3 The Raman online detection device for the entire process provided in this embodiment of the utility model.
[0026] The attached diagram shows the markings and corresponding component names:
[0027] 1-Five-way pipe, 2-Straight horizontal pipe, 3-Bypass detection pipe, 4-Online detection probe, 5-Clamp, 6-Dosage tank, 7-Drug solution self-circulation pipe, 8-Non-detection pipe, 9-Circulation pump, 10-Online Raman acquisition probe. Detailed Implementation
[0028] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the embodiments and accompanying drawings. The illustrative embodiments and descriptions of this utility model are only used to explain this utility model and are not intended to limit this utility model.
[0029] In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, it will be apparent to those skilled in the art that these specific details are not necessary to implement the present invention. In other embodiments, well-known structures are not specifically described in order to avoid obscuring the present invention.
[0030] Throughout this specification, references to "an embodiment," "an example," or "an example" mean that a particular feature, structure, or characteristic described in connection with that embodiment or example is included in at least one embodiment of the present invention. Therefore, the phrases "an embodiment," "an example," "an example," or "an example" appearing in various places throughout the specification do not necessarily refer to the same embodiment or example. Furthermore, specific features, structures, or characteristics can be combined in one or more embodiments or examples in any suitable combination and / or sub-combination. Moreover, those skilled in the art will understand that the illustrations provided herein are for illustrative purposes and are not necessarily drawn to scale. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.
[0031] In the description of this utility model, the terms "front", "rear", "left", "right", "up", "down", "vertical", "horizontal", "high", "low", "inner", and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting the scope of protection of this utility model.
[0032] Example 1
[0033] like Figures 1-3 As shown, this utility model embodiment provides a detection device, including a five-way pipe 1, the five-way pipe 1 including a straight horizontal pipe 2, the straight horizontal pipe 2 being used to install in the self-circulating pipeline of the production line medicine liquid; one end of the straight horizontal pipe 2 is the inlet of the medicine liquid to be tested, and the other end is the outlet of the medicine liquid to be tested;
[0034] The straight horizontal tube 2 has multiple openings, and an online detection probe 4 is sealed and installed at each opening.
[0035] The detection device of this utility model can be directly installed on the self-circulating pipeline of the medicine solution in the workshop preparation system by inserting the probes of the online detection device into the pipeline. The detection process does not require the medicine solution to be discharged. The detection can be completed during the circulation of the medicine solution, thereby achieving the purpose of not wasting intermediate medicine solution in the detection process. At the same time, it can also achieve process monitoring of the medicine solution content throughout the entire production process and obtain the content status of the entire production process in real time.
[0036] In one specific implementation, the online detection probe 4 includes two temperature probes and one Raman probe.
[0037] In one specific implementation, a bypass detection tube 3 is installed at the opening, and the online detection probe 4 is installed inside the bypass detection tube 3.
[0038] In one specific implementation, the outer end of the bypass detection tube 3 is sealed to the online detection probe 4 by a clamp 5, which improves the sealing performance of the probe and the bypass detection tube and ensures the normal use of the detection device.
[0039] In one specific implementation, the two ends of the straight horizontal pipe 2 are provided with installation joints.
[0040] Secondly, this utility model provides an online detection device suitable for the entire Raman process, including a drug preparation tank 6, the top and bottom of which are connected by a drug liquid self-circulation pipe 7. The detection device is installed on the drug liquid self-circulation pipe 7, and the two ends of the straight horizontal pipe 2 are respectively connected to the drug liquid self-circulation pipe 7.
[0041] This invention relates to an online Raman spectroscopy system for the entire process. By directly embedding a probe-equipped pipe into a self-circulating pharmaceutical solution pipeline, the self-circulating solution continuously "flushes" the straight-through horizontal pipe during detection, keeping it synchronized with the pharmaceutical solution being tested. This improves detection accuracy and enables process monitoring of the pharmaceutical solution content throughout the entire production process, allowing for real-time acquisition of the content information. Furthermore, this online Raman spectroscopy system eliminates the need to draw the pharmaceutical solution out to the detection device for rinsing, significantly saving on cleaning solutions.
[0042] In one specific embodiment, a non-detection pipe 8 connected in parallel with the straight horizontal pipe 2 is also installed on the self-circulating drug solution pipe 7. Valves are installed at both ends of the non-detection pipe 8. In this invention, a non-detection pipe 8 is also connected in parallel to the straight horizontal pipe 2. When the probe needs maintenance or replacement, the valves on the non-detection pipe 8 are opened, and the valves at both ends of the straight horizontal pipe 2 are closed, allowing the drug solution to circulate normally through the non-detection pipe 8.
[0043] In one specific implementation, a circulation pump 9 is installed on the self-circulating pipeline 7 of the medicine solution.
[0044] In a specific implementation, the online detection probe 4 is an online Raman acquisition probe 10.
[0045] In one specific implementation, at least two detection devices are installed in parallel on the self-circulating pipeline 7 for the medicine solution.
[0046] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of this utility model. It should be understood that the above description is only a specific embodiment of this utility model and is not intended to limit the scope of protection of this utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the scope of protection of this utility model.
Claims
1. A detection device, characterized in that, It includes a five-way pipe (1), which includes a straight horizontal pipe (2), which is used to be installed in the self-circulating pipeline of the production line medicine liquid; one end of the straight horizontal pipe (2) is the inlet of the medicine liquid to be tested, and the other end is the outlet of the medicine liquid to be tested; The straight horizontal tube (2) has multiple openings, and an online detection probe (4) is sealed and installed at each opening.
2. The detection device according to claim 1, characterized in that, The online detection probe (4) includes a temperature probe and a Raman probe.
3. The detection device according to claim 1, characterized in that, A bypass detection tube (3) is installed at the opening, and the online detection probe (4) is installed inside the bypass detection tube (3).
4. The detection device according to claim 3, characterized in that, The outer end of the bypass detection tube (3) is sealed to the online detection probe (4) by a clamp (5).
5. The detection device according to claim 1, characterized in that, The straight horizontal tube (2) is provided with installation joints at both ends.
6. A Raman online detection device suitable for the entire process, comprising a reagent preparation tank (6), wherein the top and bottom of the reagent preparation tank (6) are connected by a reagent self-circulation pipe (7), characterized in that, The drug liquid self-circulation pipeline (7) is equipped with any of the detection devices described in claims 1 to 5, and the two ends of the straight horizontal pipe (2) are respectively connected to the drug liquid self-circulation pipeline (7).
7. The online detection device suitable for the entire Raman process according to claim 6, characterized in that, The liquid circulation pipeline (7) is also equipped with a non-detection pipeline (8) connected in parallel with the straight horizontal pipe (2), and valves are installed at both ends of the non-detection pipeline (8).
8. The online detection device suitable for the entire Raman process according to claim 6, characterized in that, A circulation pump (9) is installed on the self-circulation pipeline (7) of the medicine solution.
9. The online detection device suitable for the entire Raman process according to claim 6, characterized in that, The online detection probe (4) is an online Raman acquisition probe (10).
10. The online detection device suitable for the entire Raman process according to claim 6, characterized in that, At least two detection devices are installed in parallel on the self-circulating pipeline (7) for the medicine solution.