Multi-channel switchable solid phase flow synthesis reaction device

Abstract

The utility model discloses a kind of solid-phase flow synthesis reaction devices of multi-channel switchable, comprising: reaction disc, multiple reaction chambers are equipped on reaction disc;Pedestal, including fluid inlet seat and fluid outlet seat;Inflow through-hole is equipped on fluid inlet seat;Outflow through-hole is equipped on fluid outlet seat;The gap between fluid inlet seat and fluid outlet seat is adjustable, can be inserted and removed by reaction disc;When solid-phase flow synthesis reaction, reaction disc is inserted into the gap between fluid inlet seat and fluid outlet seat, reaction chamber is sealingly connected with inflow through-hole and outflow through-hole.The utility model can realize that equipment is automatically continuous multiple solid-phase synthesis, improve synthesis efficiency, solved the problem that existing technology needs frequent manual loading and unloading reaction chamber in continuous multiple solid-phase flow synthesis process.

Description

Technical Field

[0001] This utility model relates to the field of solid-phase flow synthesis technology, specifically to a multi-channel switchable solid-phase flow synthesis reaction apparatus. Background Technology

[0002] Solid-phase flow synthesis is a commonly used technique for synthesizing molecules such as peptides and nucleic acids. The reaction takes place on a solid support in a fixed position, and the products are immobilized on the solid support, thus enabling automatic separation of the products from other substances.

[0003] Patent specification CN219072968U discloses a reactor suitable for automated continuous flow synthesis, facilitating the placement of solid-phase carriers of various specifications. This reactor can be applied to continuous flow synthesis in solid phases and enables automated control of the synthesis process, allowing for program-controlled operation, eliminating manual intervention, saving manpower, and shortening the overall synthesis time. Furthermore, the reactor designed in this utility model patent is small in size, compact in structure, low in cost, and offers good operational flexibility and adaptability, overcoming the shortcomings of expensive, less flexible, and less adaptable fully automated synthesis instruments in the field of peptide solid-phase synthesis.

[0004] However, the aforementioned existing technology, like most solid-phase synthesis reactors, contains only a single reaction chamber, and each synthesis requires manual loading and unloading of the solid support, making it unsuitable for applications requiring multiple continuous synthesis, such as self-optimization. Utility Model Content

[0005] To address the aforementioned technical problems and shortcomings in this field, this invention provides a multi-channel switchable solid-phase flow synthesis reaction apparatus, which can solve the problem of frequent manual loading and unloading of the reaction chamber during continuous solid-phase flow synthesis processes.

[0006] The specific technical solution is as follows:

[0007] A multi-channel switchable solid-phase flow synthesis reactor, comprising:

[0008] A reaction plate, which has multiple reaction chambers;

[0009] The base includes a fluid inlet seat and a fluid outlet seat; the fluid inlet seat is provided with an inflow through hole; the fluid outlet seat is provided with an outflow through hole; the gap between the fluid inlet seat and the fluid outlet seat is adjustable, allowing the reaction disk to be inserted and removed; during solid-phase flow synthesis reaction, the reaction disk is inserted into the gap between the fluid inlet seat and the fluid outlet seat, and the reaction chamber is sealed to the inflow through hole and the outflow through hole.

[0010] The aforementioned solid-phase flow synthesis reaction apparatus features multiple reaction chambers forming a switchable multi-channel system. The gap between the fluid inlet seat and the fluid outlet seat is adjustable. For example, during non-solid-phase flow synthesis reaction periods, the gap between the fluid inlet seat and the fluid outlet seat can be increased, allowing the reaction plate to be moved out and inserted. During solid-phase flow synthesis reaction, the reaction plate is inserted into the gap between the fluid inlet seat and the fluid outlet seat, aligning the reaction chamber with the inflow and outflow through holes. The gap between the fluid inlet seat and the fluid outlet seat is then adjusted to ensure a sealed connection between the reaction chamber and the inflow and outflow through holes.

[0011] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reaction apparatus further includes a first single-axis motion mechanism on the base. The first single-axis motion mechanism is connected to the fluid inlet seat and is used at least to control the fluid inlet seat to move back and forth along an axis and to position it to adjust the gap between the fluid inlet seat and the fluid outlet seat.

[0012] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reaction apparatus further includes a fixed mounting plate on the base, the fixed mounting plate having a mounting groove, and a fluid outlet seat disposed within the mounting groove.

[0013] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reactor has a boss at the bottom of the fluid outlet seat, and a support plate is fixed to the bottom surface of the mounting plate around the periphery of the mounting groove. The edge of the support plate extends into the mounting groove and forms an area that can accommodate the boss at the bottom of the fluid outlet seat; the fluid outlet seat is supported by the support plate.

[0014] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reactor base further includes a top plate with a clearance groove, through which a fluid inlet seat can move vertically. A first support plate and a second support plate are fixedly connected to both ends of the top plate, and a mounting plate is located below the top plate with both ends connected to the first and second support plates. More preferably, vertical grooves are formed on the opposite sides of both the first and second support plates, allowing the mounting plate to move vertically along these grooves and be fixed in position by corner fittings.

[0015] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reaction apparatus has reaction chambers arranged in a ring-shaped, multi-layered, uniformly spaced arrangement.

[0016] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reaction apparatus has a reaction disk mounted on a rotary drive mechanism, which is at least used to rotate and position the reaction disk to switch the reaction chambers that mate with the inlet and outlet through-holes and / or to insert and remove the reaction disk from the gap between the fluid inlet seat and the fluid outlet seat.

[0017] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reaction apparatus has a reaction disk connected to a second single-axis motion mechanism. The second single-axis motion mechanism is used at least to control the reaction disk to move back and forth along an axis and to position it, thereby switching the reaction chamber that is connected to the inlet and outlet through holes and / or inserting and removing the reaction disk into and out of the gap between the fluid inlet seat and the fluid outlet seat.

[0018] In some preferred embodiments, the multi-channel switchable solid-phase flow synthesis reaction apparatus has a reaction disk mounted on a rotary drive mechanism, which is at least used to rotate and position the reaction disk.

[0019] The rotary drive mechanism is connected to the second single-axis motion mechanism, which is at least used to control the rotary drive mechanism and the reaction disk to move back and forth along an axis and to position them.

[0020] The rotary drive mechanism and the second single-axis motion mechanism work together to switch the reaction chambers that mate with the inflow and outflow through holes and / or to insert and remove the reaction discs from the gap between the fluid inlet seat and the fluid outlet seat.

[0021] Compared with the prior art, the advantages of this utility model are as follows:

[0022] This invention enables automatic, continuous, and multiple solid-phase synthesis processes, improving synthesis efficiency and solving the problem of frequent manual loading and unloading of reaction chambers required in existing technologies for continuous, multiple solid-phase flow synthesis. Attached Figure Description

[0023] Figure 1 This is a three-dimensional structural schematic diagram of the multi-channel switchable solid-phase flow synthesis reaction device in a specific embodiment.

[0024] Figure 2 This is a cross-sectional view of the reaction disk in the multi-channel switchable solid-phase flow synthesis reactor in a specific embodiment.

[0025] Figure 3 This is a three-dimensional structural diagram of the second single-axis motion mechanism and the rotary drive mechanism in the multi-channel switchable solid-phase flow synthesis reactor in a specific embodiment.

[0026] Figure 4 This is a three-dimensional structural diagram of the base in the multi-channel switchable solid-phase flow synthesis reactor of a specific embodiment. Detailed Implementation

[0027] The present invention will be further described below with reference to the accompanying drawings and specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention.

[0028] like Figures 1 to 4As shown, a multi-channel switchable solid-phase flow synthesis reaction apparatus includes a reaction disk 1, a rotary drive mechanism 2, a base 3, and a second single-axis motion mechanism 4. The reaction disk 1 is mounted on the rotary drive mechanism 2, which at least rotates and positions the reaction disk 1. The rotary drive mechanism 2 is connected to the second single-axis motion mechanism 4 via a first connector, which at least controls the rotary drive mechanism 2, together with the reaction disk 1, to move back and forth along an axis and to position it. The reaction disk 1 has multiple reaction chambers 101 arranged in a ring-shaped, multi-layered, evenly spaced arrangement. The base 3 includes a top plate 308 and a fixed mounting plate 306. A first single-axis motion mechanism 305 is disposed above the top plate 308, and is connected to a fluid inlet seat 301 via a second connector, at least controlling the vertical movement and positioning of the fluid inlet seat 301. The top plate 308 has a clearance groove, which allows the fluid inlet seat 301 to move vertically through the top plate 308. The top plate 308 is fixedly connected to the first support plate 309 and the second support plate 310 at both ends, respectively. A fixed mounting plate 306 is located below the top plate 308 and is also connected to the first support plate 309 and the second support plate 310 at both ends. The fixed mounting plate 306 has a mounting groove, within which a fluid outlet seat 302 is installed. A boss is provided at the bottom of the fluid outlet seat 302. A support plate 307 is fixed to the bottom surface of the fixed mounting plate 306 around the perimeter of the mounting groove. The edge of the support plate 307 extends into the mounting groove and forms an area that can accommodate the boss at the bottom of the fluid outlet seat 302; the fluid outlet seat 302 is supported by the support plate 307. Vertical grooves are provided on the opposite sides of the first support plate 309 and the second support plate 310. The fixed mounting plate 306 can move up and down along the vertical grooves and is fixed in position by corner fittings 311. This design allows the gap between the fluid inlet seat 301 and the fluid outlet seat 302 to be adjustable, allowing the reaction disc 1 to be inserted and removed. The fluid inlet seat 301 is provided with an inflow through-hole 303; the fluid outlet seat 302 is provided with an outflow through-hole 304; the reaction chamber 101 can be loaded with a solid-phase carrier, and the reaction chamber 101 is at least used to dock with the inflow through-hole 303 and the outflow through-hole 304 for solid-phase flow synthesis reaction. The rotary drive mechanism 2 and the second single-axis motion mechanism 4 cooperate to switch the reaction chamber 101 docked with the inflow through-hole 303 and the outflow through-hole 304 and / or to insert and remove the reaction disk 1 into the gap between the fluid inlet seat 301 and the fluid outlet seat 302. During the solid-phase flow synthesis reaction, the reaction disk 1 is inserted into the gap between the fluid inlet seat 301 and the fluid outlet seat 302, and the reaction chamber 101 is sealed to the inflow through-hole 303 and the outflow through-hole 304.

[0029] In use of the aforementioned multi-channel switchable solid-phase flow synthesis reactor, for example: After fixing the position of the mounting plate 306 and installing the fluid outlet seat 302, a solid carrier is placed in the reaction chamber 101. The reaction disk 1 is translated and / or rotated by the second single-axis motion mechanism 4 and / or the rotary drive mechanism 2, aligning a reaction chamber vertically with the inflow through-hole 303 and the outflow through-hole 304. Then, the fluid inlet seat 301 is lowered by the first single-axis motion mechanism 305, pressing it against the reaction disk 1 together with the fluid outlet seat 302, forming a flow path from the inflow through-hole 303 to the reaction chamber 101. - A sealed fluid passage consisting of outflow through-hole 304, the other ends of inflow through-hole 303 and outflow through-hole 304 can be connected to pipes to allow fluid to pass through for solid-phase reaction; after the reaction is completed, the fluid inlet seat 301 is moved upward by the first single-axis motion mechanism 305 to release the reaction disk 1 from fixation, and the reaction disk 1 is translated and / or rotated by the second single-axis motion mechanism 4 and / or rotation drive mechanism 2 so that another reaction chamber is aligned vertically with inflow through-hole 303 and outflow through-hole 304, and the aforementioned process is repeated to carry out solid-phase reaction; in this way, a series of reaction chambers can continuously carry out solid-phase synthesis.

[0030] Furthermore, it should be understood that after reading the above description of this utility model, those skilled in the art can make various alterations or modifications to this utility model, and these equivalent forms also fall within the scope defined by the appended claims.

Claims

1. A multi-channel switchable solid-phase flow synthesis reaction apparatus, characterized in that, include: A reaction plate, which has multiple reaction chambers; The base includes a fluid inlet seat and a fluid outlet seat; the fluid inlet seat is provided with an inflow through hole; the fluid outlet seat is provided with an outflow through hole; the gap between the fluid inlet seat and the fluid outlet seat is adjustable, allowing the reaction disk to be inserted and removed; during solid-phase flow synthesis reaction, the reaction disk is inserted into the gap between the fluid inlet seat and the fluid outlet seat, and the reaction chamber is sealed to the inflow through hole and the outflow through hole.

2. The multi-channel switchable solid-phase flow synthesis reactor according to claim 1, characterized in that, The base also includes a first single-axis motion mechanism, which is connected to the fluid inlet seat and is used at least to control the fluid inlet seat to move back and forth along an axis and to position it to adjust the gap between the fluid inlet seat and the fluid outlet seat.

3. The multi-channel switchable solid-phase flow synthesis reactor according to claim 1, characterized in that, The base also includes a mounting plate with a mounting groove, and the fluid outlet seat is disposed in the mounting groove.

4. The multi-channel switchable solid-phase flow synthesis reactor according to claim 3, characterized in that, A boss is provided at the bottom of the fluid outlet seat, and a support plate is fixed on the bottom surface of the mounting plate around the periphery of the mounting groove. The edge of the support plate extends into the mounting groove and forms an area that can accommodate the boss at the bottom of the fluid outlet seat; the fluid outlet seat is supported by the support plate.

5. The multi-channel switchable solid-phase flow synthesis reactor according to claim 3, characterized in that, The base also includes a top plate with a clearance groove, which allows the fluid inlet seat to move up and down through the top plate. A first support plate and a second support plate are fixedly connected to both ends of the top plate, and a fixed mounting plate is located below the top plate with both ends connected to the first support plate and the second support plate, respectively.

6. The multi-channel switchable solid-phase flow synthesis reactor according to claim 5, characterized in that, Vertical grooves are provided on the opposite sides of the first and second support plates. The fixed mounting plate can move up and down along the vertical grooves and be fixed in position by corner pieces.

7. The multi-channel switchable solid-phase flow synthesis reactor according to claim 1, characterized in that, The reaction chamber is arranged in a ring-shaped, multi-layered, evenly spaced arrangement.

8. The multi-channel switchable solid-phase flow synthesis reactor according to claim 1, characterized in that, The reaction disk is mounted on a rotary drive mechanism, which is used at least to rotate and position the reaction disk, thereby switching the reaction chambers that mate with the inlet and outlet through holes and / or inserting and removing the reaction disk from the gap between the fluid inlet seat and the fluid outlet seat.

9. The multi-channel switchable solid-phase flow synthesis reactor according to claim 1, characterized in that, The reaction disk is connected to a second single-axis motion mechanism, which is at least used to control the reaction disk to move back and forth along an axis and to position it, thereby switching the reaction chamber that mates with the inflow through hole and the outflow through hole and / or inserting and removing the reaction disk into and out of the gap between the fluid inlet seat and the fluid outlet seat.

10. The multi-channel switchable solid-phase flow synthesis reactor according to claim 1, characterized in that, The reaction disk is mounted on a rotary drive mechanism, which is at least used to rotate and position the reaction disk. The rotary drive mechanism is connected to the second single-axis motion mechanism, which is at least used to control the rotary drive mechanism and the reaction disk to move back and forth along an axis and to position them. The rotary drive mechanism and the second single-axis motion mechanism work together to switch the reaction chambers that mate with the inflow and outflow through holes and / or to insert and remove the reaction discs from the gap between the fluid inlet seat and the fluid outlet seat.

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