A high-density polyethylene bottle is used for testing the stability of medicine under high humidity environment

Abstract

The utility model discloses a high density polyethylene bottle is to high humidity environment under the medicine stability tester, including organism, the middle part of the bottom wall of organism is provided with and places the groove, and the inside of placing groove places has the test box, and the inside of test box arc is provided with the air inlet of the lower side of the air inlet pipe, and the upper side of test box arc is provided with the exhaust pipe of the exhaust hole, and the middle part of air inlet pipe and exhaust pipe has the air inlet valve and exhaust valve in series respectively, still include sealing mechanism, sealing mechanism: it includes slide column, sealing cover, drive assembly, the slide column is slidably connected with the slide hole of the left and right sides of organism top wall respectively, and the lower end of two slide columns is fixedly connected with the upper end of sealing cover, and this high density polyethylene bottle is to high humidity environment under the medicine stability tester, can replace the mode of traditional through thread connection to drive sealing cover and move, solved the problem of the sealing effect of sealing cover because of the damage of screw rod, further guaranteed the accuracy of experiment.

Description

Technical Field

[0001] This utility model relates to the field of testing equipment technology, specifically to a high-density polyethylene bottle stability tester for pharmaceuticals under high humidity conditions. Background Technology

[0002] High-density polyethylene (HDPE) bottles are a commonly used packaging material, widely used in pharmaceuticals, food, cosmetics, and other fields. A drug stability tester can detect the sealing performance of HDPE bottles under high humidity conditions, thus determining the protective effect of HDPE bottles on pharmaceuticals and ensuring their stability and safety. (Existing technology: Authorization Publication Number CN) Patent 221147986U discloses a sealing performance testing device, including a testing chamber and a lithium battery to be tested. The testing chamber has a cap at its upper end and a testing cavity inside. A built-in placement platform is located below the testing cavity. Although this device can drive two screws to rotate via a drive device to position the cap and close the testing chamber, the two screws are exposed to the external environment. Over time, dust and other debris from the external environment will adhere to the outside of the screws. Dust particles will accelerate the wear of the mating surface between the screw and the slider, resulting in a decrease in thread accuracy. This will cause the cap to move unevenly, ultimately reducing the sealing effect and affecting the accuracy of subsequent experiments. Therefore, we propose a high-density polyethylene bottle stability testing instrument for pharmaceuticals under high humidity conditions. Utility Model Content

[0003] The technical problem this invention aims to solve is to overcome existing defects and provide a high-density polyethylene bottle stability tester for pharmaceuticals in high humidity environments. Through the coordinated arrangement of a push rod and a trapezoidal block, the sealing cap can be moved, ultimately closing the test chamber. This replaces the traditional method of moving the sealing cap via a threaded connection, solving the problem of the sealing cap's sealing effect being affected by screw damage, further ensuring the accuracy of the experiment, and effectively addressing the problems in the background technology.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a high-density polyethylene bottle drug stability tester under high humidity environment, including a body, a placement groove in the middle of the bottom wall of the body, a test chamber placed inside the placement groove, an air inlet with an air inlet pipe in the lower side of the arc surface of the test chamber, an exhaust pipe in the exhaust hole in the upper side of the arc surface of the test chamber, an air inlet valve and an exhaust valve connected in series in the middle of the air inlet pipe and the exhaust pipe, and also including a sealing mechanism;

[0005] Sealing mechanism: It includes sliding columns, sealing cover, and driving assembly. The sliding columns are slidably connected to sliding holes on the left and right sides of the top wall of the machine body. The lower ends of the two sliding columns are fixedly connected to the upper end of the sealing cover. The sealing cover corresponds to the upper and lower positions of the test chamber. The sealing cover is driven by the driving assembly. Through the cooperation of the push rod and the trapezoidal block, the sealing cover can be moved to close the test chamber. This can replace the traditional method of moving the sealing cover by threaded connection, solve the problem of the sealing effect of the sealing cover being affected by the damage of the screw, and further ensure the accuracy of the experiment.

[0006] Furthermore, a microcontroller is installed at the right end of the machine body. The input terminal of the microcontroller is electrically connected to an external power supply, which enables it to regulate the electrical components inside the device.

[0007] Furthermore, the drive assembly includes guide slides, a connecting plate, a push rod, a mounting plate, a trapezoidal seat, and a mounting groove. The mounting groove is located on the upper side of the body. Guide slides are respectively provided on the upper side of the mounting groove. The front ends of the two guide slides are slidably connected to the corresponding sliding holes provided on the rear end of the connecting plate. A push rod is provided in the middle of the lower end of the connecting plate. The upper ends of the two slides are fixedly connected to the lower end of the mounting plate. A trapezoidal seat is provided in the middle of the upper end of the mounting plate. The lower end of the push rod contacts the inclined surface of the upper end of the trapezoidal seat, which can drive the sealing cover to move through the slides.

[0008] Furthermore, the drive assembly also includes an electric push rod, which is disposed on the upper side of the rear wall of the mounting groove. The front end of the telescopic end of the electric push rod is fixedly connected to the rear end of the connecting plate, and the input end of the electric push rod is electrically connected to the output end of the microcontroller, so that the push rod can be moved by the connecting plate.

[0009] Furthermore, a fixing plate is provided on the right side of the upper end of the sealing cover, and a laser rangefinder is provided on the right side of the lower end of the fixing plate. The laser rangefinder is bidirectionally electrically connected to the microcontroller and can detect the distance between the sealing cover and the bottom wall of the machine body.

[0010] Furthermore, humidity sensors are respectively installed on the upper and lower sides of the outer arc surface of the test chamber. The probes at the middle of the rear end of the two humidity sensors are located inside the test chamber. The humidity sensors are bidirectionally electrically connected to the microcontroller, enabling them to detect the humidity inside the test chamber.

[0011] Furthermore, springs are respectively provided between the upper end of the sealing cover and the top wall of the machine body. The springs are all sleeved on the outside of the lower side of the sliding column. The tension generated by the spring contraction will drive the sealing cover to move upward and reset.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: This high-density polyethylene bottle has the following advantages for drug stability testing instruments in high humidity environments:

[0013] By using the push rod and trapezoidal block in combination, the sealing cover can be moved to close the test chamber. This replaces the traditional method of moving the sealing cover via a threaded connection, solving the problem of the sealing cover's sealing effect being affected by screw damage, and further ensuring the accuracy of the experiment. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the sealing mechanism of this utility model;

[0016] Figure 3 This is a schematic diagram of the front sectional structure of the present invention.

[0017] In the diagram: 1. Body, 2. Microcontroller, 3. Placement slot, 4. Test box, 5. Sealing mechanism, 51. Sliding column, 52. Sealing cover, 53. Drive assembly, 531. Guide sliding column, 532. Connecting plate, 533. Push rod, 534. Mounting plate, 535. Trapezoidal base, 536. Electric push rod, 537. Mounting slot, 6. Fixing plate, 7. Laser rangefinder, 8. Humidity sensor, 9. Spring, 10. Inlet pipe, 11. Exhaust pipe. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] Please see Figure 1-3 This embodiment provides a technical solution: a high-density polyethylene bottle drug stability tester under high humidity environment, including a body 1, a placement groove 3 in the middle of the bottom wall of the body 1, a test chamber 4 placed inside the placement groove 3, an air inlet 10 in the lower side of the inner arc surface of the test chamber 4, and an exhaust pipe 11 in the exhaust hole in the upper side of the inner arc surface of the test chamber 4. An air inlet valve and an exhaust valve are connected in series in the middle of the air inlet pipe 10 and the exhaust pipe 11, respectively. The operator connects the air inlet pipe 10 and the exhaust pipe 11 to an external pipe (the flange one outside the air inlet pipe 10 and the flange two of the external pipe are connected by screws). After connection, the air inlet valve and the exhaust valve are opened. Water vapor will then enter the interior of the air inlet pipe 10 through the external pipe, and the water vapor inside the air inlet pipe 10 will enter the interior of the test chamber 4. The air inside the test chamber 4 will be discharged through the exhaust pipe 11, thereby increasing the humidity inside the test chamber 4. It also includes a sealing mechanism 5.

[0020] Sealing mechanism 5: It includes sliding columns 51, sealing cover 52, and driving assembly 53. The sliding columns 51 are slidably connected to sliding holes on the left and right sides of the top wall of the machine body 1, respectively. The lower ends of the two sliding columns 51 are fixedly connected to the upper ends of the sealing cover 52. The sealing cover 52 corresponds to the upper and lower positions of the test chamber 4. The sealing cover 52 is driven by the driving assembly 53. The driving assembly 53 includes guide sliding columns 531, connecting plate 532, push rod 533, mounting plate 534, trapezoidal seat 535, and mounting groove 537. The mounting groove 537 is located on the upper side inside the machine body 1, and guide sliding columns 531 are respectively provided on the upper side inside the mounting groove 537. The front ends of the two guide pins 531 are slidably connected to the corresponding sliding holes at the rear end of the connecting plate 532. A push rod 533 is provided in the middle of the lower end of the connecting plate 532. The upper ends of the two guide pins 51 are fixedly connected to the lower end of the mounting plate 534. A trapezoidal seat 535 is provided in the middle of the upper end of the mounting plate 534. The lower end of the push rod 533 contacts the inclined surface at the upper end of the trapezoidal seat 535. The drive assembly 53 also includes an electric push rod 536. The electric push rod 536 is located on the upper side of the rear wall of the mounting groove 537. The front end of the telescopic end of the electric push rod 536 is fixedly connected to the rear end of the connecting plate 532. The input end of the electric push rod 536 is connected to... When the output of the microcontroller 2 is electrically connected, the electric push rod 536 starts operating. The telescopic end of the electric push rod 536 extends, causing it to move forward along the guide slide post 531 via the connecting plate 532, carrying the push rod 533. At this time, the guide slide post 531 provides a guiding support, reducing the radial force applied to the electric push rod 536 by the connecting plate 532 and preventing bending deformation of the telescopic end of the electric push rod 536 (the radial force of the electric push rod 536 is borne by the sliding of the guide slide post 531; the electric push rod 536 is only subjected to axial force). During the forward movement of the push rod 533, the push rod 533 will... A downward thrust is applied to the trapezoidal seat 535 via its inclined surface, causing the push rod 533 to move the mounting plate 534 downwards via the trapezoidal seat 535. The mounting plate 534 then moves the sealing cover 52 downwards via the sliding column 51. When the distance between the testing device and the bottom wall of the body 1 is equal to h, the lower surface of the sealing cover 52 will contact the upper surface of the test chamber 4, thereby sealing the test chamber 4. This method can replace the traditional method of moving the sealing cover 52 via a threaded connection, solving the problem of the sealing effect of the sealing cover 52 being affected by damage to the screw, and further ensuring the accuracy of the experiment.

[0021] Among them, a microcontroller 2 is set on the right end of the body 1. The input terminal of the microcontroller 2 is electrically connected to an external power supply and can regulate the electrical components inside the device.

[0022] The sealing cover 52 has a fixing plate 6 on the upper right side and a laser rangefinder 7 on the lower right side of the fixing plate 6. The laser rangefinder 7 is bidirectionally electrically connected to the microcontroller 2. The light source built into the laser rangefinder 7 emits a laser beam to the bottom wall of the body 1. When the laser comes into contact with the bottom wall of the body 1, it is reflected. Then the laser rangefinder 7 receives the reflected light. The laser rangefinder 7 calculates the distance between the laser rangefinder 7 and the bottom wall of the body 1 by measuring the round-trip time (TOF) or phase difference of the laser.

[0023] The test chamber 4 has humidity sensors 8 installed on the upper and lower sides of its outer arc surface. The probes at the middle of the rear end of the two humidity sensors 8 are located inside the test chamber 4. The humidity sensors 8 are bidirectionally electrically connected to the microcontroller 2. The humidity sensors 8 utilize the adsorption of water vapor on conductive materials to change the resistance value of the conductive materials. When the water vapor content in the test chamber 4 increases, the conductive materials of the humidity sensors 8 absorb water vapor, resulting in a decrease in resistance value. The humidity sensors 8 then determine the humidity by measuring the change in resistance value.

[0024] Among them, springs 9 are respectively installed between the upper end of the sealing cover 52 and the top wall of the machine body 1. The springs 9 are all sleeved on the outside of the lower side of the slide column 51. The tension generated by the contraction of the springs 9 will drive the sealing cover 52 to move upward (the operator can clean and lubricate the springs 9 regularly, which can further improve the service life of the springs 9).

[0025] The working principle of the high-density polyethylene bottle drug stability tester under high humidity environment provided by this utility model is as follows: During the use of the high-density polyethylene bottle drug stability tester under high humidity environment, the operator first measures the height of the test chamber 4 (e.g., a), and then measures the heights of the placement slot 3, laser rangefinder 7, and sealing cap 52 (e.g., b, c, and d). Then, the high-density polyethylene bottle containing the drug is placed in the middle of the bottom wall of the test chamber 4. Next, the distance between the laser rangefinder 7 and the bottom wall of the machine body 1 is measured. During use, because the length of the fixing plate 6 is greater than the exhaust pipe 11, the laser emitted by the built-in light source of the laser rangefinder 7 will directly reach the bottom wall of the machine body 1. Upon contact with the wall, the light is reflected, and then the laser rangefinder 7 receives the reflected light. The laser rangefinder 7 calculates the distance between itself and the bottom wall of the machine body 1 by measuring the time-of-flight (TOF) or phase difference of the laser beam (e). The laser rangefinder 7 then transmits the detected information to the microcontroller 2 via its built-in data transmission module. The microcontroller 2 receives the detected data via its built-in serial communication port. The operator adds the height of the laser rangefinder 7 to this distance and subtracts the height of the sealing cover 52 to obtain the distance from the lower end of the sealing cover 52 to the bottom wall of the machine body 1 (f, where f = e + cd). Subtracting the height of the test box 4 and the placement slot 3 from this distance gives the distance of the sealing cover 52. The distance between the lower end of the sealing cover 52 and the upper end of the test box 4 (e.g., g, g = fab) is calculated by subtracting the distance between the lower end of the sealing cover 52 and the upper end of the test box 4 from the distance between the laser rangefinder 7 and the bottom wall of the body 1. This gives the distance at which the sealing cover 52 stops operating (e.g., h, h = eg). Then, through the control of the microcontroller 2, the electric push rod 536 starts to operate, and the telescopic end of the electric push rod 536 begins to extend, causing the electric push rod 536 to move forward along the guide slide column 531 via the connecting plate 532, carrying the push rod 533. At this time, the guide slide column 531 provides a guiding support, reducing the radial force applied to the electric push rod 536 by the connecting plate 532 and preventing the telescopic end of the electric push rod 536 from bending and deforming. (The radial force of the electric push rod 536 is borne by the sliding bearing of the guide column 531, and the electric push rod 5636 is only subjected to the front and rear axial force.) During the forward movement of the push rod 533, the push rod 533 will exert a downward thrust on the trapezoidal seat 535 through the inclined surface of the trapezoidal seat 535, thereby causing the push rod 533 to drive the mounting plate 534 to move downward through the trapezoidal seat 535. The mounting plate 534 will drive the sealing cover 52 to move downward through the sliding column 51. The spring 9 extends, and during the movement of the sealing cover 52, it will also drive the laser rangefinder 7 to move downward through the fixing plate 6. When the distance between the laser rangefinder 7 and the bottom wall of the body 1 is equal to h, the lower surface of the sealing cover 52 will contact the upper surface of the test box 4, thereby sealing the test box 4.The operator then connects the intake pipe 10 and exhaust pipe 11 to the external pipe (the flange one on the outside of the intake pipe 10 and exhaust pipe 11 is connected to the flange two on the external pipe with screws). After connection, the intake valve and exhaust valve are opened. Water vapor then enters the interior of the intake pipe 10 through the external pipe, and the water vapor inside the intake pipe 10 enters the interior of the test chamber 4. The air inside the test chamber 4 is discharged through the exhaust pipe 11, thereby increasing the humidity inside the test chamber 4. The humidity sensor 8 utilizes the adsorption effect of water vapor on the conductive material, changing the resistance value of the conductive material. When the water vapor content inside the test chamber 4 increases, the conductive material of the humidity sensor 8 absorbs water vapor, causing the resistance value to decrease. The humidity sensor 8 then determines the humidity by measuring the change in resistance value. Afterward, the humidity sensor 8 transmits the detected information to the microcontroller 2 through the built-in data transmission module. The microcontroller 2 receives the detected data through the built-in serial communication port, and then takes an intermediate value based on the data provided by the two humidity sensors 8. This intermediate value is the humidity inside the test chamber 4. When the humidity inside the test chamber 4 reaches the set value, the operator uses an external timing device (mobile phone or timer) to time the test. After the specified test time is reached, the telescopic end of the electric push rod 536 begins to shorten under the control of the microcontroller 2. This causes the electric push rod 536 to move backward along the guide slide column 531 via the connecting plate 532, carrying the push rod 533. During the backward movement of the push rod 533, the tension generated by the contraction of the spring 9 will drive the sealing cover 52 to move upward (the operator can regularly clean and lubricate the spring 9 to further improve its service life). Thus, the sealing cover 52 drives the connecting plate 532 to move upward and reset via the slide column 51. The connecting plate 532 then drives the trapezoidal block 535 to move upward and reset. At the same time, the sealing cover 52 will also separate from the test chamber 4, thereby opening the test chamber 4. The operator then takes out the high-density polyethylene bottle containing the medicine, opens the high-density polyethylene bottle containing the medicine, and observes the state of the medicine to determine whether the high-density polyethylene bottle can effectively protect the medicine in a high-humidity environment.

[0026] It is worth noting that the microcontroller 2 disclosed in the above embodiments can be an ATmega328P, the electric actuator 536 can be a dytp2000-550 / 50-x, the laser rangefinder 7 can be an HMLDM-UD100A, and the humidity sensor 8 can be a YF-WSD300B. The microcontroller 2 controls the operation of the electric actuator 536, the laser rangefinder 7, and the humidity sensor 8 using methods commonly used in the prior art.

[0027] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A high-density polyethylene bottle stability tester for pharmaceuticals under high humidity conditions, comprising a body (1), a placement groove (3) provided in the middle of the bottom wall of the body (1), a test chamber (4) placed inside the placement groove (3), an air inlet and an air inlet pipe (10) provided in the lower side of the inner arc surface of the test chamber (4), and an exhaust pipe (11) in the exhaust hole provided in the upper side of the inner arc surface of the test chamber (4), wherein an air inlet valve and an exhaust valve are connected in series in the middle of the air inlet pipe (10) and the exhaust pipe (11), characterized in that: It also includes a sealing mechanism (5); Sealing mechanism (5): It includes a sliding column (51), a sealing cover (52), and a driving assembly (53). The sliding column (51) is slidably connected to the sliding holes opened on the left and right sides of the top wall of the body (1). The lower ends of the two sliding columns (51) are fixedly connected to the upper ends of the sealing cover (52). The sealing cover (52) corresponds to the upper and lower positions of the test box (4). The sealing cover (52) is driven by the driving assembly (53).

2. The high-density polyethylene bottle stability testing instrument for pharmaceuticals under high humidity conditions according to claim 1, characterized in that: A microcontroller (2) is provided at the right end of the body (1), and the input terminal of the microcontroller (2) is electrically connected to an external power supply.

3. The stability tester for pharmaceuticals in high-humidity environments using high-density polyethylene bottles according to claim 2, characterized in that: The drive assembly (53) includes guide slides (531), connecting plate (532), push rod (533), mounting plate (534), trapezoidal seat (535), and mounting groove (537). The mounting groove (537) is located on the upper side inside the body (1). Guide slides (531) are respectively provided on the upper side inside the mounting groove (537). The front ends of the two guide slides (531) are slidably connected to the corresponding sliding holes provided on the rear end of the connecting plate (532). The push rod (533) is provided in the middle of the lower end of the connecting plate (532). The upper ends of the two slides (51) are fixedly connected to the lower end of the mounting plate (534). The trapezoidal seat (535) is provided in the middle of the upper end of the mounting plate (534). The lower end of the push rod (533) is in contact with the inclined surface of the upper end of the trapezoidal seat (535).

4. The stability tester for pharmaceuticals in high humidity environments using high-density polyethylene bottles according to claim 3, characterized in that: The drive assembly (53) also includes an electric push rod (536), which is disposed on the upper side of the rear wall of the mounting groove (537). The front end of the telescopic end of the electric push rod (536) is fixedly connected to the rear end of the connecting plate (532), and the input end of the electric push rod (536) is electrically connected to the output end of the microcontroller (2).

5. The stability tester for pharmaceuticals in high-humidity environments using high-density polyethylene bottles according to claim 2, characterized in that: A fixing plate (6) is provided on the right side of the upper end of the sealing cover (52), and a laser rangefinder (7) is provided on the right side of the lower end of the fixing plate (6). The laser rangefinder (7) is bidirectionally electrically connected to the microcontroller (2).

6. The stability tester for pharmaceuticals in high humidity environments using high-density polyethylene bottles according to claim 2, characterized in that: Humidity sensors (8) are respectively installed on the upper and lower sides of the outer arc surface of the test box (4). The probes at the middle of the rear end of the two humidity sensors (8) are located inside the test box (4). The humidity sensors (8) are bidirectionally electrically connected to the microcontroller (2).

7. The high-density polyethylene bottle stability tester for pharmaceuticals under high humidity conditions according to claim 1, characterized in that: Springs (9) are respectively provided between the upper end of the sealing cover (52) and the top wall of the body (1), and the springs (9) are all sleeved on the outside of the lower side of the slide column (51).

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