A high-efficiency mixing and granulating machine for pharmaceutical production

Abstract

This utility model provides a high-efficiency mixing and granulating machine for pharmaceutical production, relating to the field of pharmaceutical manufacturing. The high-efficiency mixing and granulating machine includes a frame and a mixing drum. The outer surface of the mixing drum is fixedly connected to the frame. A separation mechanism is installed inside the frame. The separation mechanism includes a drive screw, one end of which is rotatably connected to the frame. A support plate is threadedly connected to the outer surface of the drive screw, and the outer surface of the support plate is slidably connected to the frame. A sprocket is rotatably connected to the top surface of the support plate. Through the coordinated arrangement of the components in the separation mechanism, this high-efficiency mixing and granulating machine for pharmaceutical production enables the separation of components from the mixing drum after use. This optimization facilitates subsequent cleaning of the device, completely solving the problem of difficult-to-clean dead corners in existing devices, further enhancing the practicality of this device.

Description

Technical Field

[0001] This utility model relates to a granulator, specifically a high-efficiency mixing granulator for pharmaceutical production, belonging to the field of pharmaceutical production technology. Background Technology

[0002] Wet granulation is a process in which drug powder and excipients are uniformly mixed in a mixer, a liquid binder is sprayed in to form a soft mass, and then the mass is cut into wet granules by a high-speed cutter. The core technology involves controlling the amount of binder and the mixing and cutting parameters to optimize granule flowability and uniformity, meeting the requirements for subsequent tableting or capsule filling, and ensuring product quality and production efficiency.

[0003] A search revealed a Chinese patent with publication number CN210934846U, which discloses a high-efficiency wet mixing granulation machine for pharmaceutical production. The machine includes a main body, a cover plate installed on the upper surface of the main body, an adhesive tube arranged near the left side of the upper end of the cover plate, a feeding tube arranged near the right side of the upper end of the cover plate, a No. 1 motor fixedly installed at the bottom of the main body, and a hollow plate installed on the upper end of the No. 1 motor.

[0004] While the above solution can perform granulation, there is still room for optimization in practical applications. Since the granulation component of the current device is fixedly installed in the main body, it is difficult to clean the residue in the dead corners by simply using a spray method to clean the granulation component, thus resulting in low practicality. To address this issue, we provide a high-efficiency mixing granulator for pharmaceutical production. Utility Model Content

[0005] The purpose of this invention is to provide a high-efficiency mixing and granulation machine for pharmaceutical production to solve the above-mentioned problems, thereby addressing the issue that existing technologies are difficult to clean thoroughly from dead corners and have low practicality.

[0006] This utility model is achieved through the following technical solution: a high-efficiency mixing granulator for pharmaceutical production, comprising a device frame and a mixing drum, wherein the outer surface of the mixing drum is fixedly connected to the device frame, and a separation mechanism is provided inside the device frame, wherein the separation mechanism comprises an active screw, one end of which is rotatably connected to the device frame, and a bearing plate is threadedly connected to the outer surface of the active screw, and the outer surface of the bearing plate is slidably connected to the device frame;

[0007] A sprocket is rotatably connected to the top surface of the bearing plate, and a sliding block is fixedly connected to the inner wall of the sprocket. An active rod is rotatably connected to the inner wall of the device frame, and a limiting groove adapted to the sliding block is opened on the outer surface of the active rod.

[0008] Preferably, two drive motors are fixedly connected to the inner wall of the device frame, and the output ends of the two drive motors are fixedly connected to the drive screw and the drive rod, respectively. The outer surface of the device frame is equipped with control buttons for the drive motors, which can be used to start and stop the drive motors.

[0009] Preferably, a cover is fixedly connected to the outer surface of the support plate, and the outer surface of the cover is slidably connected to the device frame. The device frame effectively limits the position of the cover, making the cover more stable during vertical movement.

[0010] Preferably, a second sprocket is rotatably connected to the top surface of the cover, and a drive chain is driven to the outer surface of the second sprocket. The outer surface of the drive chain is driven to the first sprocket, and the second sprocket can be driven to rotate synchronously by driving the drive chain.

[0011] Preferably, the inner wall of the cover is rotatably connected to a driven connecting shaft, one end of which is fixedly connected to a second sprocket. By driving the second sprocket to rotate, the driven connecting shaft can be driven to rotate simultaneously.

[0012] Preferably, a scraper is fixedly connected to the outer surface of the driven connecting shaft, and a stirring rod is fixedly connected to the outer surface of the scraper. By driving the scraper and the stirring rod to rotate, the raw materials in the mixing tank can be effectively mixed and stirred.

[0013] Preferably, a granulation mechanism is provided below the device frame. The granulation mechanism includes a granulation component. A discharge cylinder is fixedly connected to the top surface of the granulation component. The end of the discharge cylinder away from the granulation component is fixedly connected to a mixing tank through a sealing flange. A screw extrusion roller is rotatably connected to the inner wall of the discharge cylinder. The granulation component is composed of a cutting mechanism and a drying mechanism. Through the cooperation of the two, the mixed raw materials can be effectively cut and dried in an integrated manner. The cutting mechanism and the drying mechanism are existing technologies and will not be described in detail in this application.

[0014] This utility model provides a high-efficiency mixing and granulation machine for pharmaceutical production, which has the following beneficial effects:

[0015] This high-efficiency mixing granulator for pharmaceutical production achieves the separation of components from the mixing tank after use through the coordinated arrangement of parts in the separation mechanism. This optimization facilitates subsequent cleaning of the equipment and completely solves the problem of difficult cleaning of dead corners in existing equipment, further enhancing the practicality of this device.

[0016] This high-efficiency mixing granulator for pharmaceutical production achieves uniform material extrusion through the coordinated arrangement of components in the granulation mechanism, thereby completing the cutting and drying molding processes. The material is evenly discharged through the auger spiral extrusion roller, significantly improving the pharmaceutical production cycle and effectively enhancing overall production efficiency. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0018] Figure 2 This is a three-dimensional structural diagram of the separation mechanism of this utility model;

[0019] Figure 3 This is a three-dimensional structural diagram of the bearing plate of this utility model;

[0020] Figure 4 This is a three-dimensional structural diagram of the granulation mechanism of this utility model.

[0021] [Explanation of Key Component Symbols]

[0022] 1. Device frame; 2. Mixing tank;

[0023] 3. Separation mechanism; 301. Driving screw; 302. Bearing plate; 303. Sprocket one; 304. Sliding block; 305. Driving rod; 306. Limiting slot; 307. Drive motor; 308. Cover; 309. Sprocket two; 310. Transmission chain; 311. Driven connecting shaft; 312. Scraper frame; 313. Stirring rod;

[0024] 4. Granulation mechanism; 401. Granulation component; 402. Discharge cylinder; 403. Screw extrusion roller. Detailed Implementation

[0025] This utility model provides a high-efficiency mixing and granulation machine for pharmaceutical production.

[0026] Please refer to it again. Figure 1 , Figure 2 , Figure 3 and Figure 4 The device includes a frame 1 and a mixing tank 2. The outer surface of the mixing tank 2 is fixedly connected to the frame 1. An electrical control box is installed on the outer surface of the frame 1. The electrical control box is electrically connected to the municipal power supply through wires, thereby ensuring that the electrical equipment in this application is powered normally.

[0027] The device frame 1 is equipped with a separation mechanism 3. The separation mechanism 3 includes a drive screw 301. One end of the drive screw 301 is rotatably connected to the device frame 1. The outer surface of the drive screw 301 is threadedly connected to a bearing plate 302. The outer surface of the bearing plate 302 is slidably connected to the device frame 1. By driving the drive screw 301 to rotate, the bearing plate 302 can be driven to slide vertically within the device frame 1 synchronously.

[0028] A sprocket 303 is rotatably connected to the top surface of the bearing plate 302. A sliding block 304 is fixedly connected to the inner wall of the sprocket 303. An active rod 305 is rotatably connected to the inner wall of the device frame 1. A limiting groove 306 that matches the sliding block 304 is opened on the outer surface of the active rod 305. Through the coordinated action of the sliding block 304 and the limiting groove 306, the vertical movement of the sprocket 303 driven by the bearing plate 302 is not affected when the sprocket 303 is rotated.

[0029] Two drive motors 307 are fixedly connected to the inner wall of the device frame 1. The output ends of the two drive motors 307 are fixedly connected to the active screw 301 and the active rod 305 respectively. The outer surface of the device frame 1 is equipped with control buttons for the drive motors 307. The drive motors 307 can be started and stopped by the control buttons.

[0030] The drive motor 307 is a common electrical device in the prior art. This application will not elaborate on its model and internal structure. It can also be replaced by other power sources.

[0031] A cover 308 is fixedly connected to the outer surface of the bearing plate 302. The outer surface of the cover 308 is slidably connected to the device frame 1. The device frame 1 effectively limits the position of the cover 308, making the cover 308 more stable during vertical movement. A sealing plate is fixedly installed on the bottom surface of the cover 308. The thickness of the sealing plate is greater than that of the cover 308, so that the height of the cover 308 can be finely adjusted when the sealing plate contacts the inner wall of the mixing tank 2.

[0032] The top surface of the cover 308 is rotatably connected to a second sprocket 309. The outer surface of the second sprocket 309 is connected to a transmission chain 310. The outer surface of the transmission chain 310 is connected to the first sprocket 303. By driving the first sprocket 303 to rotate, the transmission chain 310 can be driven simultaneously.

[0033] The inner wall of the cover 308 is rotatably connected to a driven connecting shaft 311. One end of the driven connecting shaft 311 is fixedly connected to a sprocket 309. A scraper 312 is fixedly connected to the outer surface of the driven connecting shaft 311. A stirring rod 313 is fixedly connected to the outer surface of the scraper 312. By driving the driven connecting shaft 311 to rotate, the scraper 312 and the stirring rod 313 can be driven to rotate synchronously, effectively mixing and stirring the raw materials in the mixing tank 2.

[0034] A granulation mechanism 4 is provided below the device frame 1. The granulation mechanism 4 includes a granulation component 401. The top surface of the granulation component 401 is fixedly connected to a discharge cylinder 402. The end of the discharge cylinder 402 away from the granulation component 401 is fixedly connected to the mixing tank 2 through a sealing flange. A screw extrusion roller 403 is rotatably connected to the inner wall of the discharge cylinder 402. The granulation component 401 is composed of a cutting mechanism and a drying mechanism. Through the cooperation of the two, the mixed raw materials can be effectively cut and dried in an integrated molding process. The cutting mechanism and the drying mechanism are existing technologies and will not be described in detail in this application.

[0035] A rectangular insert is provided at the end of the driven connecting shaft 311 away from the sprocket 309. A rectangular slot adapted to the rectangular insert is provided at one end of the auger spiral extrusion roller 403. By embedding the rectangular insert into the rectangular slot, the auger spiral extrusion roller 403 can be driven to rotate synchronously when the driven connecting shaft 311 is driven to rotate, so as to effectively and evenly transport the mixed material to the pelletizing component 401.

[0036] The structural diagrams of the components shown in the attached figures are exemplary. The specific implementation should be adapted and optimized by considering the functional requirements, assembly conditions and process limitations in the actual application scenario, and adjusting the structural parameters, size specifications and connection methods accordingly.

[0037] Working principle: First, through the coordinated action of the drive rod 305 and the limiting slot 306 and sliding block 304, the first sprocket 303 can be effectively driven to rotate synchronously. The rotation of the first sprocket 303 drives the transmission chain 310, which in turn drives the driven connecting shaft 311 on the bottom surface of the second sprocket 309 to rotate inside the cover 308. The rotation of the driven connecting shaft 311 drives the scraper frame 312 and the stirring rod 313 to rotate synchronously, effectively mixing the materials. After mixing, the drive screw 301 drives the bearing plate 302 to move downward. The downward movement of the bearing plate 302 drives the cover 308 to move downward, and the downward movement of the cover 308 drives the driven connecting shaft 311 to move downward synchronously. The mixture is fed into the auger screw extrusion roller 403. At this time, driving the drive rod 305 again will synchronously drive the auger screw extrusion roller 403 to rotate. The rotation of the auger screw extrusion roller 403 effectively and evenly conveys the mixed material to the granulation component 401 for cutting and drying. After the device is used, driving the drive screw 301 again will drive the support plate 302 to move upward. The upward movement of the support plate 302 will drive the cover 308 to move upward simultaneously. The upward movement of the cover 308 can open the opening above the mixing tank 2, thereby facilitating the cleaning of the mixing tank 2 and the parts below the cover 308. This completely solves the problem of difficult cleaning of dead corners in existing devices, further making the device more practical.

[0038] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A high-efficiency mixing granulator for pharmaceutical production, comprising a frame (1) and a mixing tank (2), characterized in that: The outer surface of the mixing tank (2) is fixedly connected to the device frame (1). The device frame (1) is provided with a separation mechanism (3). The separation mechanism (3) includes an active screw (301). One end of the active screw (301) is rotatably connected to the device frame (1). The outer surface of the active screw (301) is threadedly connected to a bearing plate (302). The outer surface of the bearing plate (302) is slidably connected to the device frame (1). The top surface of the bearing plate (302) is rotatably connected to a sprocket (303), and the inner wall of the sprocket (303) is fixedly connected to a sliding block (304). The inner wall of the device frame (1) is rotatably connected to an active rod (305), and the outer surface of the active rod (305) is provided with a limiting groove (306) that is compatible with the sliding block (304).

2. The high-efficiency mixing and granulating machine for pharmaceutical production according to claim 1, characterized in that: Two drive motors (307) are fixedly connected to the inner wall of the device frame (1), and the output ends of the two drive motors (307) are fixedly connected to the active screw (301) and the active rod (305) respectively.

3. The high-efficiency mixing and granulating machine for pharmaceutical production according to claim 1, characterized in that: The outer surface of the support plate (302) is fixedly connected to a cover (308), and the outer surface of the cover (308) is slidably connected to the device frame (1).

4. The high-efficiency mixing and granulating machine for pharmaceutical production according to claim 3, characterized in that: The top surface of the cover (308) is rotatably connected to a second sprocket (309), and the outer surface of the second sprocket (309) is connected to a transmission chain (310). The outer surface of the transmission chain (310) is connected to the first sprocket (303).

5. The high-efficiency mixing and granulation machine for pharmaceutical production according to claim 3, characterized in that: The inner wall of the cover (308) is rotatably connected to a driven connecting shaft (311), one end of which is fixedly connected to a sprocket (309).

6. The high-efficiency mixing and granulating machine for pharmaceutical production according to claim 5, characterized in that: A scraper (312) is fixedly connected to the outer surface of the driven connecting shaft (311), and a stirring rod (313) is fixedly connected to the outer surface of the scraper (312).

7. The high-efficiency mixing and granulating machine for pharmaceutical production according to claim 1, characterized in that: A granulation mechanism (4) is provided below the device frame (1). The granulation mechanism (4) includes a granulation component (401). The top surface of the granulation component (401) is fixedly connected to a discharge cylinder (402). One end of the discharge cylinder (402) away from the granulation component (401) is fixedly connected to the mixing tank (2) through a sealing flange. The inner wall of the discharge cylinder (402) is rotatably connected to an auger spiral extrusion roller (403).

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