A magnetic rack for adsorption of biotin beads

Abstract

This invention belongs to the field of biological detection technology, specifically relating to a magnetic rack for adsorbing biotinylate magnetic beads. The rack includes: a frame comprising a first surface and a second surface arranged opposite to each other; at least one set of first magnetic blocks and at least one set of second magnetic blocks spaced apart on the first surface and / or the second surface; and at least one set of grooves for placing PCR tubes formed on the first surface and / or the second surface adjacent to the first magnetic blocks; and a centrifuge tube support module detachably connected to the edge surface of the rack for placing centrifuge tubes. This invention, by creating grooves on the surface of the rack and detachably mounting the centrifuge tube support module on the edge surface of the rack, allows for the installation of centrifuge tube supports adapted to different centrifuge tubes, thereby meeting the needs of actual experiments and improving practicality.

Description

Technical Field

[0001] This invention belongs to the field of biological detection technology, specifically relating to a magnetic rack for adsorbing biotin magnetic beads. Background Technology

[0002] In biological and genetic laboratories, magnetic racks are often used to separate or clean reagents. During separation, multiple very small magnetic beads are placed inside centrifuge tubes containing reagents. When the centrifuge tubes are placed on a magnetic rack, the magnetic beads are rapidly attracted to one side of the tube under the influence of the magnetic field, thus completing the separation process.

[0003] In actual experiments, various centrifuge tubes are used as containers, so multiple magnetic racks of different sizes are often needed to achieve the magnetic attraction of centrifuge tubes of different sizes; for example, the use of 1.5ml, 2ml, 10ml, 15ml or 50ml centrifuge tubes commonly found on the market.

[0004] In view of this, the present invention provides a magnetic rack for adsorbing biotin magnetic beads to meet the above requirements. Utility Model Content

[0005] To achieve the above objectives, this utility model provides the following technical solution: a magnetic rack for adsorbing biotin beads, comprising:

[0006] The frame includes a first surface and a second surface disposed opposite to each other, at least one set of first magnetic blocks and at least one set of second magnetic blocks spaced apart on the first surface and / or the second surface, and at least one set of grooves spaced apart on the first surface and / or the second surface and adjacent to the second magnetic blocks for placing PCR tubes; and

[0007] Centrifuge tube support modules are detachably connected to the edge surface of the frame for placing centrifuge tubes.

[0008] Preferably, the first magnetic block is embedded between the first surface and the second surface, and the two outward end faces of the first magnetic block extend to at least the first surface and the second surface, respectively.

[0009] Preferably, the inner wall of the groove is connected to the first magnetic block.

[0010] Preferably, the first magnetic block is a long strip extending vertically from one end toward the centrifuge tube support module.

[0011] Preferably, the frame body has a connecting block extending along its edge surface on the edge surface relative to the centrifuge tube support module;

[0012] The centrifuge tube support module has a connecting groove on its surface relative to the frame that is adapted to the connecting block.

[0013] Preferably, the surface of the connecting block is provided with at least one set of positioning holes for locking with fasteners, and the surface of the centrifuge tube support module is provided with at least one set of through holes adapted to the positioning holes for fastener end insertion.

[0014] Preferably, the surface of the centrifuge tube support module is provided with a placement hole that cooperates with the first magnetic block and / or the second magnetic block. The placement hole is used to place the centrifuge tube, and when the centrifuge tube is placed in the placement hole, the periphery of the centrifuge tube can be closely close to the first magnetic block and / or the second magnetic block.

[0015] Preferably, the centrifuge tube assembly includes a first centrifuge tube, a second centrifuge tube, and a third centrifuge tube;

[0016] The centrifuge tube support module includes a second centrifuge tube support adapted to the first centrifuge tube, a third centrifuge tube support adapted to the second centrifuge tube, and a first centrifuge tube support adapted to the third centrifuge tube.

[0017] Preferably, the outward-facing end face of the second magnetic block is an inclined surface that is adapted to and forms a support for the end of the third centrifuge tube.

[0018] Compared with the prior art, the beneficial effects of this utility model are:

[0019] This invention improves practicality by creating grooves on the surface of the frame and detachably installing centrifuge tube support modules on the edge of the frame, allowing for the installation of centrifuge tube supports that are compatible with different centrifuge tubes. Attached Figure Description

[0020] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0021] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0022] Figure 2 This is a schematic diagram of the exploded structure of this utility model;

[0023] Figure 3 These are schematic diagrams of three different types of centrifuge tube support structures according to this utility model;

[0024] Figure 4 This is a schematic diagram of the structure for placing the PCR tube in this utility model;

[0025] Figure 5 This is a schematic diagram of the structure of the second centrifuge tube holder of this utility model when the first centrifuge tube is placed;

[0026] Figure 6 This is a schematic diagram of the structure of the third centrifuge tube holder of this utility model when the second centrifuge tube is placed;

[0027] Figure 7 This is a schematic diagram of the structure of the first centrifuge tube support of this utility model when the third centrifuge tube is placed.

[0028] In the diagram: 1. Frame; 11. First surface; 12. Second surface; 2. First magnetic block; 3. Second magnetic block; 4. Groove; 5. Centrifuge tube support module; 51. First centrifuge tube support; 52. Second centrifuge tube support; 53. Third centrifuge tube support; 6. Centrifuge tube fitting; 61. PCR tube; 62. First centrifuge tube; 63. Second centrifuge tube; 64. Third centrifuge tube; 7. Connecting block; 8. Connecting groove; 9. Positioning hole; 10. Through hole. Detailed Implementation

[0029] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0030] This utility model relates to a magnetic frame for adsorbing biotinylate magnetic beads, such as... Figures 1-7 As shown, the device includes a frame 1 and centrifuge tube support modules 5 detachably connected to opposite edge surfaces of the frame 1 for placing centrifuge tubes 6. The surface of the centrifuge tube support module 5 has placement holes for placing the centrifuge tubes 6. The centrifuge tube support module 5 is located at opposite edges of the frame 1, forming an "I" shape with the frame 1. The bottom centrifuge tube support module 5 serves as a base, and the top centrifuge tube support module 5 is used to insert and place the centrifuge tubes 6.

[0031] Among them, such as Figure 2As shown, the frame 1 includes a first surface 11 and a second surface 12 disposed opposite to each other. At least one set of first magnetic blocks 2 and at least one set of second magnetic blocks 3 are spaced apart and embedded on the first surface 11 and / or the second surface 12. At least one set of grooves 4 for placing PCR tubes 61 are spaced apart on the first surface 11 and / or the second surface 12 and disposed adjacent to the first magnetic blocks 2. In addition to the above-described embedding method, the first magnetic blocks 2 can also be embedded between the first surface 11 and the second surface 12, and the two outward end faces of the first magnetic blocks 2 extend at least to the first surface 11 and the second surface 12, respectively. This embedding method can reduce the number of first magnetic blocks 2 embedded, so that the first surface 11 and the second surface 12 can share a single first magnetic block 2, thereby reducing costs. Similarly, the second magnetic blocks 3 can also be embedded in the above manner to further reduce costs.

[0032] The placement hole on the surface of the centrifuge tube support module 5 can be configured to cooperate with the first magnetic block 2 and / or the second magnetic block 3 so that when the centrifuge tube 6 is placed in the placement hole, the periphery of the centrifuge tube 6 can be closely attached to the first magnetic block 2 and / or the second magnetic block 3.

[0033] like Figure 4 As shown, at least a portion of the groove 4 is adapted to the end of the PCR tube 61 so that the PCR tube 61 can be placed vertically within the groove 4; simultaneously, the groove 4 can be spaced eight times along the height direction of the frame 1, which facilitates the adaptation and placement of eight rows of PCR tubes 61. It should be noted that the PCR tube 61 in this embodiment is a commercially available 0.2ml PCR tube.

[0034] Furthermore, in order to enable the first magnetic block 2 to better adsorb the magnetic beads in the PCR tube 61 and improve the separation efficiency, a notch is opened in the inner wall of the groove 4 to connect the first magnetic block 2. When the PCR tube 61 is placed in the groove 4, the outer side of the PCR tube 61 can adhere to the first magnetic block 2, thereby increasing the magnetic attraction and accelerating the adsorption of the magnetic beads by the first magnetic block 2.

[0035] Furthermore, such as Figures 4-7 As shown, in order to satisfy the magnetic bead adsorption of the eight-row PCR tubes 61 and the centrifuge tubes 6 inserted on the centrifuge tube support module 5, the first magnetic block 2 is, for example, a long strip extending along the height direction of the frame 1. This long strip configuration can be easily connected with the multiple sets of grooves 4, and can also cooperate with the centrifuge tube support module 5 so that when centrifuge tubes 6 are inserted, the adsorption area with the axial circumference of the centrifuge tubes 6 can be increased, thereby improving the adsorption efficiency. Of course, the configuration of the first magnetic block 2 is not limited to the above method, and can also be other suitable configurations.

[0036] Among them, such as Figure 2As shown, a connecting block 7 extending along the length of the edge surface is formed on the edge surface of the frame 1 relative to the centrifuge tube support module 5; a connecting groove 8 adapted to the connecting block 7 is provided on the surface of the centrifuge tube support module 5 relative to the frame 1. In this embodiment, the opposite edge surfaces of the frame 1 are the top and bottom surfaces of the frame 1 in the above-mentioned "I"-shaped structure. Preferably, for example, the connecting block 7 is a trapezoidal protrusion, and the connecting groove 8 is a trapezoidal sliding groove adapted to the connecting block 7. The centrifuge tube support module 5 can be detachably installed on the edge surface of the frame 1 through the sliding connection between the connecting block 7 and the connecting groove 8.

[0037] Furthermore, to improve the stability of the centrifuge tube support module 5 during installation and prevent it from slipping off the edge of the frame 1 due to external forces, at least one set of positioning holes 9 are provided on the top surface of the connecting block 7 for locking with fasteners. At least one set of through holes 10, adapted to the positioning holes 9, are provided on the surface of the centrifuge tube support module 5 for inserting the end of the fastener. Taking a bolt as an example, after the centrifuge tube support module 5 is installed, the positioning holes 9 and through holes 10 are coaxial and collinear. By inserting the end of the bolt into the through hole 10 and then threading it into the positioning hole 9, the centrifuge tube support module 5 is locked, effectively limiting its sliding. Additionally, the top opening of the through hole 10 can be recessed to match the head of the fastener, so that when the fastener is inserted, the head of the fastener does not protrude from the surface of the centrifuge tube support module 5, improving aesthetics and stability when used as a base.

[0038] like Figure 3 , Figures 4-7 As shown, the centrifuge tube set 6 includes a first centrifuge tube 62, a second centrifuge tube 63, and a third centrifuge tube 64. The first centrifuge tube 62 is a commercially available 1.5ml or 2ml centrifuge tube, the second centrifuge tube 63 is a commercially available 10ml or 15ml centrifuge tube, and the third centrifuge tube 64 is a commercially available 50ml centrifuge tube.

[0039] The centrifuge tube support module 5 includes a first centrifuge tube support 51, a second centrifuge tube support 52, and a third centrifuge tube support 53. The only difference between the first centrifuge tube support 51, the second centrifuge tube support 52, and the third centrifuge tube support 53 is the size of the placement holes they have. For example, the second centrifuge tube support 52 is adapted to the radial dimension of the first centrifuge tube 62, the third centrifuge tube support 53 is adapted to the radial dimension of the second centrifuge tube 63, and the first centrifuge tube support 51 is adapted to the radial dimension of the third centrifuge tube 64. In use, such as... Figures 5-7 In addition to the combination shown, the first centrifuge tube support 51, the second centrifuge tube support 52 and the third centrifuge tube support 53 can be further combined with each other according to the type of centrifuge tube actually used and then installed on the opposite edge surfaces of the frame 1.

[0040] Although the size difference between a 1.5mL centrifuge tube and a 2mL centrifuge tube is minimal, there is still a difference in size. Therefore, in order to better adsorb and support the end of the third centrifuge tube 64, the outward-facing end face of the second magnetic block 3 is an inclined surface adapted to the end of the third centrifuge tube 64. The slope and position of this inclined surface are the same as the bottom conical surface of a commonly used 1.5mL centrifuge tube. It protrudes a certain length on the first surface 11 and / or the second surface 12 to fit against the bottom conical surface of the 1.5mL centrifuge tube to form support. At the same time, the inclined surface can increase the adsorption area and improve the adsorption efficiency, so that the magnetic beads in the centrifuge tube can quickly gather into a cluster next to the magnetic block.

[0041] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A magnetic rack for adsorbing biotin beads, characterized in that, include: The frame (1) includes a first surface (11) and a second surface (12) disposed opposite to each other, at least one set of first magnetic blocks (2) and at least one set of second magnetic blocks (3) are spaced apart and embedded on the first surface (11) and / or the second surface (12), and at least one set of grooves (4) for placing PCR tubes (61) are spaced apart on the surfaces of the first surface (11) and / or the second surface (12) and adjacent to the first magnetic blocks (2); and Centrifuge tube support module (5) is detachably connected to the edge surface of the frame (1) for placing centrifuge tubes (6).

2. The magnetic rack for adsorbing biotin beads according to claim 1, characterized in that: The first magnetic block (2) is embedded between the first surface (11) and the second surface (12), and the two outward end faces of the first magnetic block (2) extend to the first surface (11) and the second surface (12) respectively.

3. The magnetic rack for adsorbing biotin beads according to claim 1, characterized in that: The inner wall of the groove (4) is connected to the first magnetic block (2).

4. A magnetic rack for adsorbing biotin beads according to claim 1, characterized in that: The first magnetic block (2) is a long strip that extends vertically from the end toward the centrifuge tube support module (5).

5. A magnetic rack for adsorbing biotin beads according to claim 1, characterized in that: The frame (1) has a connecting block (7) extending along its edge surface on the edge surface relative to the centrifuge tube support module (5); The centrifuge tube support module (5) has a connecting groove (8) on its surface relative to the frame (1) that is compatible with the connecting block (7).

6. A magnetic rack for adsorbing biotin beads according to claim 5, characterized in that: The surface of the connecting block (7) is provided with at least one set of positioning holes (9) for locking with fasteners, and the surface of the centrifuge tube support module (5) is provided with at least one set of through holes (10) adapted to the positioning holes (9) for fastener end insertion.

7. A magnetic rack for adsorbing biotin beads according to any one of claims 1-6, characterized in that: The surface of the centrifuge tube support module (5) is provided with a placement hole that cooperates with the first magnetic block (2) and / or the second magnetic block (3). The placement hole is used to place the centrifuge tube (6), and when the centrifuge tube (6) is placed in the placement hole, the periphery of the centrifuge tube (6) can be closely close to the first magnetic block (2) and / or the second magnetic block (3).

8. A magnetic rack for adsorbing biotin beads according to claim 7, characterized in that: The centrifuge tube assembly (6) includes a first centrifuge tube (62), a second centrifuge tube (63), and a third centrifuge tube (64); The centrifuge tube support module (5) includes a second centrifuge tube support (52) adapted to the first centrifuge tube (62), a third centrifuge tube support (53) adapted to the second centrifuge tube (63), and a first centrifuge tube support (51) adapted to the third centrifuge tube (64).

9. A magnetic rack for adsorbing biotin beads according to claim 8, characterized in that: The outer end face of the second magnetic block (3) is an inclined surface that is adapted to the end of the third centrifuge tube (64) and forms a support.

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