A magnetic bead reagent-assisted structure

Abstract

This utility model belongs to the field of biotechnology, specifically relating to a magnetic bead reagent auxiliary structure, including a base, a supporting corner plate disposed on the outer corner of the base, an elastic stabilizer disposed between the base and the supporting corner plate, and a fixing seat located at the upper end of the base; the base is provided with multiple lower fixing grooves, and the fixing seat is provided with multiple upper fixing grooves that match the lower fixing grooves. This utility model, through structural optimization, aims to directly fit with cardboard packaging to fix reagent bottles or test tubes, achieving the effects of small footprint and recyclability.

Description

Technical Field

[0001] This invention belongs to the field of biotechnology, specifically relating to a magnetic bead reagent auxiliary structure. Background Technology

[0002] The core principle of magnetic bead extraction is as follows: Superparamagnetic nanospheres coated with specific functional groups are used as a solid-phase carrier. Under specific buffer conditions, the target substance is specifically adsorbed onto the surface of the magnetic beads through hydrophobic interactions, electrostatic interactions, ionic interactions, affinity binding, or hydrogen bonding. Under an applied magnetic field, the magnetic beads, along with the adsorbed target substance, are rapidly and directionally adsorbed onto the sidewall or bottom of the container. After removing the supernatant containing impurities and removing the magnetic field, the magnetic beads are resuspended in a washing or elution solution for washing to remove residual impurities or elute the target substance, ultimately yielding the purified target substance. This method is widely used in molecular biology, proteomics, cell biology, and clinical diagnostics due to its advantages of simplicity, efficiency, and mildness.

[0003] Magnetic bead reagents often require low-temperature transportation. In low-temperature environments, the reagent tubes are more prone to breakage due to bumps during transportation. Therefore, it is necessary to protect the reagent tubes from bumps.

[0004] The document with authorization announcement number CN220595623U discloses a biological nanomagnetic bead reagent kit, including a reagent kit body. A placement rack is slidably disposed within the reagent kit body. Four fixed ears arranged in a rectangular pattern are fixedly disposed at the bottom end of the reagent kit body. A sliding rod is fixedly connected between two relatively far fixed ears. Sliding sleeves are slidably disposed on the outer surfaces of the two sliding rods facing each other. When the reagent kit body is transported and shakes, the placement rack moves down, causing the guide rod to slide in the connecting ear. At the same time, the other end of the guide rod rotates in the sliding sleeve and slides in the sliding rod, causing the shock-absorbing spring to be compressed and deformed. Then, the force of the shock-absorbing spring resets, causing the sliding sleeve to return to its original position, thereby absorbing the shock of the reagent tubes placed in the placement rack.

[0005] The device has several drawbacks: it occupies a large volume at the bottom, and the entire reagent kit needs to be manufactured from scratch using rigid materials. This significantly increases costs compared to the currently common economical packaging such as cardboard boxes, hindering its widespread adoption. Utility Model Content

[0006] To address the aforementioned problems, the purpose of this invention is to provide a magnetic bead reagent auxiliary structure. Through structural optimization, it is intended to be directly compatible with cardboard packaging to secure reagent bottles or test tubes, achieving the effects of small space occupation and recyclability.

[0007] To achieve the above objectives, the technical solution of this utility model is as follows:

[0008] A magnetic bead reagent auxiliary structure includes a base, a supporting corner plate disposed on the outer corner of the base, an elastic stabilizer disposed between the base and the supporting corner plate, and a fixing seat located at the upper end of the base; the base is provided with a plurality of lower fixing grooves, and the fixing seat is provided with a plurality of upper fixing grooves that match the lower fixing grooves.

[0009] As a further preferred embodiment of the present invention, the base and the fixed seat are connected by an adjusting member; the adjusting member includes at least two fixing studs symmetrically arranged at both ends of the base, adjusting holes arranged on the fixed seat and matching the fixing studs, and at least two fixing nuts screwed onto the fixing studs and used to abut against the upper and lower surfaces of the fixed seat respectively.

[0010] As a further preferred embodiment of the present invention, the elastic stabilizer includes a support spring, one end of which is connected to the side of the base and the other end of which is connected to the inner surface of one plate of the support corner plate.

[0011] As a further preferred embodiment of the present invention, the elastic stabilizer further includes a plug-in plate disposed at the bottom of one of the plates of the support corner plate, and a positioning groove disposed on the lower surface of the base and slidably connected to the plug-in plate.

[0012] As a further preferred embodiment of the present invention, the elastic stabilizer further includes a ball bearing disposed on the inner top surface of the positioning groove and used for connection with the upper surface of the plug plate.

[0013] As a further preferred embodiment of the present invention, the elastic stabilizer further includes a positioning post disposed on the upper side of the base, and an abutment post disposed on the inner surface of the support corner plate and slidably connected to the positioning post.

[0014] As a further preferred embodiment of this utility model, the openings of two adjacent positioning grooves are located on two adjacent sides of the base.

[0015] As a further preferred embodiment of this utility model, a first resistance-enhancing layer is provided on the lower surface of the plug plate, and a second resistance-enhancing layer is provided on the outer surface of the support corner plate.

[0016] As a further preferred embodiment of this utility model, a lower buffer layer is provided on the bottom surface of the lower fixing groove.

[0017] As a further preferred embodiment of the present invention, at least one of the upper fixing grooves penetrates the fixing seat.

[0018] The beneficial effects of this utility model are:

[0019] This utility model uses a base and a fixed seat to form a whole with the reagent bottle or test tube placed inside, which improves the structure's ability to resist longitudinal shaking. The combination of the base with supporting corner plates and elastic stabilizers further enhances the structure's ability to resist lateral shaking, reducing the occurrence of reagent bottle or test tube breakage during transportation.

[0020] The structure provided by this utility model can be reused and can be directly applied to existing cardboard packaging, which has the advantages of being economical and practical. Attached Figure Description

[0021] Appendix Figure 1 This is a schematic diagram of the structure of this utility model.

[0022] Appendix Figure 2 This is a schematic diagram of the base structure of this utility model from a top view.

[0023] Appendix Figure 3 This is a schematic diagram of the structure of the fixing base of this utility model from a top view.

[0024] Appendix Figure 4 Appendix to this utility model Figure 1 A partial structural diagram.

[0025] Attached diagram: 1. Base; 2. Supporting corner plate; 3. Elastic stabilizer; 4. Fixing base;

[0026] Lower fixing groove 11, lower buffer layer 12, weight reduction groove 13;

[0027] Second resistance-enhancing layer 21;

[0028] Support spring 31, plug plate 32, positioning groove 33, ball 34, positioning post 35, abutment post 36, first resistance layer 37;

[0029] Upper fixing groove 41, upper buffer layer 42;

[0030] Fixed stud 51, adjusting hole 52, fixing nut 53. Detailed Implementation

[0031] In the description of this utility model, it should be understood that the terms "upper", "lower", "inner", "outer", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that the utility model product is usually placed in during use, or the orientation or positional relationship that is commonly understood by those skilled in the art. They are only used to facilitate the description of this utility model and to simplify the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0032] Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be interpreted as indicating or implying relative importance.

[0033] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, terms such as "set" and "connection" should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0034] As attached Figure 1 ~Appendix Figure 4 As shown, this embodiment provides a magnetic bead reagent auxiliary structure, mainly used to replace the existing fixing structure for fixing reagent bottles inside the cardboard box, thereby improving the fixing and protection effect of the reagent bottle. The specific structure includes: a base 1, a support corner plate 2 disposed on the outer corner of the base 1, an elastic stabilizer 3 disposed between the base 1 and the support corner plate 2, and a fixing seat 4 located at the upper end of the base 1. The base 1 can be a cuboid, and the support corner plate 2 can be a right-angled plate structure commonly used in the prior art. "The support corner plate 2 disposed on the outer corner of the base 1" means that the corners formed by the two sides of the base 1 are structurally matched with the support corner plate 2, with their side plates parallel to each other, of similar height, and with a certain distance between them, for mounting the elastic stabilizer 3. There are four supporting corner plates 2 and four elastic stabilizers 3, corresponding to the four corners of the base 1. The supporting corner plates 2 are used to connect with the four inner corners of the cardboard packaging, and the base 1 is placed inside the cardboard packaging. The elastic stabilizers 3 refer to structures with supporting springs. Due to the presence of the elastic stabilizers 3, the supporting corner plates 2 are subjected to force and pressed tightly against the cardboard packaging, thus supporting the cardboard packaging. The four corners of the base 1 are effectively fixed inside the cardboard packaging by the force of the supporting corner plates 2. The base 1 is provided with multiple lower fixing grooves 11, and the fixing seat 4 is provided with multiple upper fixing grooves 41 that match the lower fixing grooves 11. After the reagent bottle or test tube is placed between the base 1 and the fixing seat 4 according to the specifications, the upper and lower ends of the reagent bottle or test tube are fixed by the upper fixing grooves 41 and the lower fixing grooves 11 respectively, thereby ensuring that the reagent bottle or test tube will not move relative to each other after being installed on this device, thus improving stability. The structure of the elastic stabilizer 3 and the supporting corner plate 2 enhances the ability of the base 1 to quickly absorb and convert energy when subjected to lateral shaking, thereby improving the lateral buffering capacity and effectively reducing the shaking of the suspension in the reagent bottle or test tube. Furthermore, a weight-reducing groove 13 can be provided on the base 1 to reduce the weight of the device itself.

[0035] Specifically, the base 1 and the fixed seat 4 are connected by an adjusting component. The adjusting component includes at least two fixing studs 51 symmetrically arranged at both ends of the base 1, adjusting holes 52 arranged on the fixed seat 4 and matching the fixing studs 51, and at least two fixing nuts 53 screwed onto the fixing studs 51 and used to abut against the upper and lower surfaces of the fixed seat 4 respectively. The advantage of this arrangement is that the distance between the base 1 and the fixed seat 4 can be quickly adjusted according to the height of the reagent bottle or test tube or the internal space height of the cardboard packaging, thereby increasing the applicability and practicality of the device.

[0036] Specifically, the elastic stabilizer 3 includes a support spring 31 with one end connected to the side of the base 1 and the other end connected to the inner surface of one plate of the support corner plate 2, a plug-in plate 32 disposed at the bottom of one plate of the support corner plate 2, and a positioning groove 33 disposed on the lower surface of the base 1 and slidably connected to the plug-in plate 32. Preferably, the openings of two adjacent positioning grooves 33 are located on two adjacent sides of the base 1. The arrangement of the plug-in plate 32 and the positioning grooves 33 can limit the path of the base 1 towards / away from the support corner plate 2, thereby limiting the extension and retraction path of the support spring 31 and preventing the base 1 from swaying at an unexpected angle. "The openings of two adjacent positioning grooves 33 are located on two adjacent sides of the base 1" means that there are four positioning grooves 33, which are respectively disposed at the four corners, and the openings of the positioning grooves 33 at two adjacent corners face different directions. This allows the positioning grooves 33 on the opposite side plates to connect to the plug-in plates 32 with the same direction, which not only improves the limiting and stabilizing effect but also reduces the number of components used, thus improving economy. It is worth noting that when the support spring 31 is in an uncompressed state, the end of the plug plate 32 is located at the opening of the positioning groove 33.

[0037] Preferably, the elastic stabilizer 3 further includes a ball bearing 34 disposed on the inner top surface of the positioning groove 33 and used to connect with the upper surface of the plug plate 32. This helps to reduce the friction between the plug plate 32 and the positioning groove 33, thereby fully utilizing the buffering effect of the support spring 31.

[0038] Preferably, the elastic stabilizer 3 further includes a positioning post 35 disposed on the upper side of the base 1, and an abutment post 36 disposed on the inner surface of the support corner plate 2 and slidably connected to the positioning post 35. The arrangement of the two posts always abutting each other helps to improve the stability of the movement at the upper end of the base 1, thereby ensuring the integrity and uniformity of the overall movement of the device, and thus ensuring effective protection of reagent bottles or test tubes.

[0039] Preferably, a first friction-increasing layer 37 is provided on the lower surface of the plug plate 32, and a second friction-increasing layer 21 is provided on the outer surface of the support corner plate 2. The friction-increasing layer can be made of a material with a high coefficient of friction, such as rubber, or it can be made of a textured surface to increase the coefficient of friction. These are all common technologies in the art, so they will not be described in detail here.

[0040] Preferably, a lower buffer layer 12 is provided on the bottom surface of the lower fixing groove 11. At least one upper fixing groove 41 penetrates the fixing base 4, and an upper buffer layer 42 is provided on the inner top surface of the upper fixing groove 41 that does not penetrate the fixing base 4. The upper fixing groove 41 that penetrates the fixing base 4 is designed to accommodate test tubes with greater height. The buffer layer 42 can be made of flexible materials such as rubber, thereby reducing the impact strength between the reagent bottle or test tube and the groove and enhancing its protective effect.

[0041] The auxiliary structure proposed in this embodiment has advantages over existing technologies, including at least the following: First, the combination of a base and a fixed seat integrates the reagent bottle or test tube placed inside with the device, enhancing the structure's resistance to longitudinal shaking. Second, the combination of a base, supporting corner plates, and elastic stabilizers further strengthens the structure's resistance to lateral shaking, reducing the likelihood of reagent bottles or test tubes breaking during transportation. Third, this structure is reusable and can be directly applied to existing cardboard packaging, offering advantages in terms of economy and practicality. Fourth, this structure has adjustable distance capabilities in both the lateral and longitudinal directions, further expanding its applicability.

[0042] The specific embodiments described herein are merely illustrative examples illustrating the spirit of this utility model. Those skilled in the art to which this utility model pertains may make various modifications or additions to the described specific embodiments or use similar methods to substitute them, without departing from the spirit of this utility model or exceeding the scope defined by the appended claims.

Claims

1. A magnetic bead reagent assisted structure, characterized by: It includes a base (1), a support corner plate (2) disposed on the outer corner of the base (1), an elastic stabilizer (3) disposed between the base (1) and the support corner plate (2), and a fixing seat (4) located at the upper end of the base (1); the base (1) is provided with a plurality of lower fixing grooves (11), and the fixing seat (4) is provided with a plurality of upper fixing grooves (41) matching the lower fixing grooves (11).

2. The magnetic bead reagent assisted structure according to claim 1, wherein: The base (1) and the fixed seat (4) are connected by an adjusting member; the adjusting member includes at least two fixing studs (51) symmetrically arranged at both ends of the base (1), adjusting holes (52) arranged on the fixed seat (4) and matching the fixing studs (51), and at least two fixing nuts (53) screwed onto the fixing studs (51) and used to abut against the upper and lower surfaces of the fixed seat (4) respectively.

3. The magnetic bead reagent assisted structure according to claim 1, wherein: The elastic stabilizer (3) includes a support spring (31) with one end connected to the side of the base (1) and the other end connected to the inner surface of one plate of the support corner plate (2).

4. The magnetic bead reagent assisted structure according to claim 3, wherein: The elastic stabilizer (3) also includes a plug plate (32) disposed at the bottom of one of the plates of the support corner plate (2) and a positioning groove (33) disposed on the lower surface of the base (1) and slidably connected to the plug plate (32).

5. The magnetic bead reagent assisted structure according to claim 4, wherein: The elastic stabilizer (3) also includes a ball (34) disposed on the inner top surface of the positioning groove (33) and used to connect with the upper surface of the plug plate (32).

6. The magnetic bead reagent assisted structure according to claim 4, wherein: The elastic stabilizer (3) also includes a positioning post (35) disposed on the upper side of the base (1) and an abutment post (36) disposed on the inner surface of the support corner plate (2) and slidably connected to the positioning post (35).

7. The magnetic bead reagent assisted structure according to claim 4, wherein: The openings of the two adjacent positioning slots (33) are located on two adjacent sides of the base (1).

8. The magnetic bead reagent assisted structure according to claim 4, wherein: The lower surface of the plug plate (32) is provided with a first resistance layer (37), and the outer surface of the support corner plate (2) is provided with a second resistance layer (21).

9. The magnetic bead reagent-assisted structure according to claim 1, characterized in that: A lower buffer layer (12) is provided on the bottom surface of the lower fixing groove (11).

10. The magnetic bead reagent assisted structure of claim 1, wherein: At least one of the upper fixing grooves (41) penetrates the fixing seat (4).

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