A sulfasalazine synthesis apparatus with a stirring mixing mechanism

Abstract

The utility model discloses a sulfasalazine synthetic equipment with stirring mixing mechanism relates to sulfasalazine synthetic field, including mixing jar body, break mechanism, break mechanism installs in mixing jar body top one side, lead screw, the lead screw, rotation is connected between mixing jar body inside top and bottom, wherein, the sliding sleeve is cooperated with the outside screw thread of lead screw, the connecting rod is fixed with the outside of sliding sleeve, the annular scraper is fixedly connected with connecting rod end, the annular scraper outside is attached to mixing jar body inner wall, break mechanism includes the discharge bin, the feed inlet is seted up in the middle of discharge bin top, and the device is pretreated to raw material through break mechanism, when the rotating shaft rotates, the mutual meshing of grinding teeth can carry out extrusion, shearing effect to raw material, realize the purpose of breaking, can make the powder that is relatively coarse become finer through the effect of grinding simultaneously.

Description

Technical Field

[0001] This utility model relates to the field of sulfasalazine synthesis, and in particular to a sulfasalazine synthesis apparatus with a stirring and mixing mechanism. Background Technology

[0002] Sulfasalazine is an important pharmaceutical intermediate widely used in the medical field. It is a dark yellow to brownish-yellow powder, odorless, with a melting point of 240–245°C. It is insoluble in water, slightly soluble in ethanol, and readily soluble in sodium hydroxide.

[0003] In the traditional synthesis of sulfasalazine, a simple stirred tank is typically used for the reaction. However, this traditional stirred tank has problems. First, the raw materials often have uneven particle size when added to the stirred tank. Large particles are difficult to disperse fully during stirring, resulting in uneven mixing, which in turn affects the efficiency of the synthesis reaction and the quality of the product.

[0004] Therefore, it is necessary to propose a sulfasalazine synthesis apparatus with a stirring and mixing mechanism to solve the above problems. Utility Model Content

[0005] The purpose of this invention is to provide a sulfasalazine synthesis device with a stirring and mixing mechanism to solve the problem that when raw materials are added to the stirred tank, there is often an uneven particle size. Large particles of raw materials are difficult to disperse fully during the stirring process, resulting in uneven mixing, which in turn affects the efficiency of the synthesis reaction and the quality of the product.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a sulfasalazine synthesis apparatus with a stirring and mixing mechanism, comprising:

[0007] Mixing tank;

[0008] A crushing mechanism is installed on one side of the top of the mixing tank;

[0009] The lead screw is rotatably connected between the top and bottom ends inside the mixing tank.

[0010] The lead screw is threaded with a sliding sleeve on its outer side, a connecting rod is fixed to the outer side of the sliding sleeve, and an annular scraper is fixedly connected to the end of the connecting rod. The outer side of the annular scraper is attached to the inner wall of the mixing tank.

[0011] Preferably, the crushing mechanism includes a feeding box, and the feeding box has a feeding port at the top center;

[0012] The feeding box is rotatably connected to a rotating shaft, and grinding teeth are fixed on the outer sides of the two rotating shafts. The grinding teeth on the outer sides of the two rotating shafts mesh with each other.

[0013] Preferably, the bottom of the feeding box is connected to the inside of the mixing tank, and the bottom of the feeding port corresponds to the position between the two rotating shafts.

[0014] Preferably, a first motor is fixedly connected to the top of the mixing tank, and the drive shaft at the bottom of the first motor is connected to one end of the lead screw.

[0015] Preferably, two second motors are fixed on one side of the feeding box, and the drive shafts of the two second motors are respectively connected to one end of two rotating shafts.

[0016] Preferably, an interlayer is provided between the inner wall and the outer wall of the mixing tank, and an electric heating wire is provided in the interlayer.

[0017] Preferably, a discharge pipe is provided at the bottom outer side of the mixing tank, and the discharge pipe is connected to the inside of the mixing tank.

[0018] The technical effects and advantages of this utility model are as follows:

[0019] 1. In this utility model, when the lead screw rotates, it drives the sliding sleeve to move up and down along the lead screw, thereby driving the annular scraper to move up and down through the connecting rod. During the movement, the annular scraper can continuously scrape the inner wall of the mixing tank to prevent the raw materials from clumping on the inner wall. At the same time, it can also play a role in stirring and mixing the raw materials, so that the raw materials can be fully and evenly mixed in the mixing tank. When the mixed powder raw materials need to be discharged, the annular scraper moves from top to bottom, squeezing the powder downwards and discharging it, thereby improving the output efficiency and reducing powder residue.

[0020] 2. This device pre-treats the raw materials through a crushing mechanism. When the rotating shaft rotates, the meshing grinding teeth can squeeze and shear the raw materials to achieve the purpose of crushing. At the same time, it can make coarser powders finer through the grinding action. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort, wherein:

[0022] Figure 1 This is a schematic diagram of the structure of a sulfasalazine synthesis device with a stirring and mixing mechanism according to the present invention.

[0023] Figure 2 This is a schematic diagram of the lead screw of this utility model.

[0024] Figure 3This is a schematic diagram of the internal structure of the feeding box of this utility model.

[0025] In the diagram: 1. Mixing tank; 2. Discharge pipe; 3. First motor; 4. Feed box; 5. Feed inlet; 6. Lead screw; 7. Connecting rod; 8. Sliding sleeve; 9. Annular scraper; 10. Second motor; 11. Rotating shaft; 12. Grinding teeth. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] This utility model provides, for example Figure 1 - Figure 3 The apparatus shown is a sulfasalazine synthesis device with a stirring and mixing mechanism, including a mixing tank 1;

[0028] The crushing mechanism is installed on one side of the top of the mixing tank 1. Its main function is to perform preliminary crushing of the input powder raw materials to avoid clumping, so as to facilitate better mixing and stirring reaction in the later stage.

[0029] Specifically, the crushing mechanism includes a feeding box 4, and a feeding port 5 is provided at the top center of the feeding box 4;

[0030] The feeding box 4 is rotatably connected to a rotating shaft 11. Grinding teeth 12 are fixed on the outer side of the two rotating shafts 11, and the grinding teeth 12 on the outer side of the two rotating shafts 11 mesh with each other.

[0031] Two second motors 10 are fixed on one side of the feeding box 4, and the drive shafts of the two second motors 10 are respectively connected to one end of the two rotating shafts 11.

[0032] Two second motors 10 rotate relative to each other, causing the corresponding grinding teeth 12 to mesh with each other, allowing the falling powder to enter between the grinding teeth 12 of the two rotating shafts 11. When the rotating shafts 11 rotate, the meshing grinding teeth 12 can squeeze and shear the raw materials to achieve the purpose of crushing, and at the same time, make the coarser powder finer through the grinding action.

[0033] It should be noted that the two second motors 10 are of the same model and start synchronously, and can be connected to the same switch or control system.

[0034] The bottom of the feeding box 4 is connected to the inside of the mixing tank 1. The bottom of the feeding port 5 is positioned with the two rotating shafts 11 to ensure that the raw materials can smoothly enter from the feeding port 5 and be crushed by the action of the rotating shafts 11 and the grinding teeth 12 before entering the mixing tank 1.

[0035] Lead screw 6, lead screw 6, is rotatably connected between the top and bottom ends inside the mixing tank 1;

[0036] The lead screw 6 is threaded with a sliding sleeve 8, which can move up and down on the lead screw 6. A connecting rod 7 is fixed to the outside of the sliding sleeve 8, and an annular scraper 9 is fixedly connected to the end of the connecting rod 7. The outer side of the annular scraper 9 is attached to the inner wall of the mixing tank 1.

[0037] A first motor 3 is fixedly connected to the top of the mixing tank 1, and the drive shaft at the bottom of the first motor 3 is connected to one end of the lead screw 6. The first motor 3 can be a servo motor, which can drive the lead screw 6 to rotate in both directions.

[0038] In the actual operation of this utility model, when the lead screw 6 rotates, it drives the sliding sleeve 8 to move up and down along the lead screw 6, thereby driving the annular scraper 9 to move up and down through the connecting rod 7. During the movement, the annular scraper 9 can continuously scrape the inner wall of the mixing tank 1 to prevent the raw materials from clumping on the inner wall. At the same time, it can also play the role of stirring and mixing the raw materials, so that the raw materials can be fully and evenly mixed in the mixing tank 1. When the mixed powder raw materials need to be discharged, the annular scraper 9 moves from top to bottom, squeezing the powder inside downwards and discharging it, thereby improving the output efficiency and reducing powder residue.

[0039] An interlayer is provided between the inner and outer walls of the mixing tank 1, and an electric heating wire is installed in the interlayer. By controlling the energization of the electric heating wire, the raw materials in the mixing tank 1 can be heated to provide suitable temperature conditions for the synthesis reaction of sulfasalazine.

[0040] A discharge pipe 2 is provided at the bottom of the outer side of the mixing tank 1. The discharge pipe 2 is connected to the inside of the mixing tank 1. The other end of the discharge pipe 2 is connected to a valve, which is used to discharge the reaction product from the mixing tank 1 after the synthesis reaction is completed, so as to facilitate subsequent collection and processing operations.

[0041] This device pre-treats the raw materials through a crushing mechanism, and then uses a stirring and mixing mechanism and a heating device to ensure that the raw materials are fully mixed and reacted in the mixing tank 1, thereby improving synthesis efficiency and product quality. At the same time, the design of the discharge pipe 2 also facilitates the collection of products and the cleaning and maintenance of the equipment by the operators.

[0042] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A device for synthesizing sulfasalazine with a stirring and mixing mechanism, characterized in that: include: Mixing tank (1); A crushing mechanism is installed on one side of the top of the mixing tank (1); A lead screw (6) is rotatably connected between the top and bottom ends inside the mixing tank (1); The lead screw (6) is threaded with a sliding sleeve (8), and a connecting rod (7) is fixed to the outside of the sliding sleeve (8). An annular scraper (9) is fixedly connected to the end of the connecting rod (7), and the annular scraper (9) is attached to the inner wall of the mixing tank (1).

2. The sulfasalazine synthesis apparatus with a stirring and mixing mechanism according to claim 1, characterized in that: The crushing mechanism includes a feeding box (4), and a feeding port (5) is provided at the top center of the feeding box (4); The feeding box (4) is rotatably connected to a rotating shaft (11), and grinding teeth (12) are fixed on the outside of the two rotating shafts (11). The grinding teeth (12) on the outside of the two rotating shafts (11) mesh with each other.

3. The apparatus for synthesizing sulfasalazine with a stirring and mixing mechanism according to claim 2, characterized in that: The bottom of the feeding box (4) is connected to the inside of the mixing tank (1), and the bottom of the feeding port (5) corresponds to the position between the two rotating shafts (11).

4. The apparatus for synthesizing sulfasalazine with a stirring and mixing mechanism according to claim 1, characterized in that: The mixing tank (1) is fixedly connected to the top of a first motor (3), and the drive shaft at the bottom of the first motor (3) is connected to one end of the lead screw (6).

5. The apparatus for synthesizing sulfasalazine with a stirring and mixing mechanism according to claim 2, characterized in that: Two second motors (10) are fixed on one side of the feeding box (4), and the drive shafts of the two second motors (10) are respectively connected to one end of the two rotating shafts (11).

6. The apparatus for synthesizing sulfasalazine with a stirring and mixing mechanism according to claim 1, characterized in that: An interlayer is provided between the inner and outer walls of the mixing tank (1), and an electric heating wire is provided in the interlayer.

7. The apparatus for synthesizing sulfasalazine with a stirring and mixing mechanism according to claim 1, characterized in that: A discharge pipe (2) is provided at the bottom of the outer side of the mixing tank (1), and the discharge pipe (2) is connected to the inside of the mixing tank (1).

Images