A biological sample preparation assistance device

Abstract

The utility model discloses a biological sample preparation auxiliary equipment, including the box, the middle part of box upper end is provided with the placing groove, the upside of box inside is provided with the cavity, the downside of box inside is provided with electric heating wire, the lower side of the front end of box is set up and is provided with the drain pipe in the drain outlet respectively, the front side of two drain pipes all has the drain valve in series, still include fixed establishment, the fixed establishment includes the clamping plate, the connecting plate and drive assembly, the connecting plate is slidably connected with the slide groove of the left and right sides of the inner arc surface of placing groove respectively, and the opposite inside end of two connecting plates all is provided with the clamping plate, and the outer arc surface of two clamping plates all contacts with the inner arc surface of placing groove, and drive assembly sets up in the inside of cavity, and clamping plate is driven by drive assembly.

Description

Technical Field

[0001] This utility model relates to the field of pharmacokinetic research technology, specifically to an auxiliary device for biological sample preparation. Background Technology

[0002] Biological sample preparation aids are devices used in pharmacokinetic studies to help researchers and medical personnel efficiently and accurately process and prepare biological samples (such as blood, tissues, and cells), ensuring sample quality and the reliability of experimental results.

[0003] In the prior art, patent publication number CN 209576743 U discloses a constant temperature water bath. Although the device can move the clamps by springs to fix the reaction tube, the springs will be corroded when exposed to water for a long time, which will reduce the fixing effect of the clamps and affect the stability of the reaction tube. Inaccurate fixing position of the reaction tube will eventually lead to errors in the experiment. Utility Model Content

[0004] The technical problem this invention aims to solve is to overcome existing defects and provide an auxiliary device for biological sample preparation. Through the coordinated arrangement of a mounting plate and a drive rod, two clamping plates can be moved, and finally, the clamping plates fix the container. This replaces the traditional method of moving the clamping plates by springs, solving the problem that the clamping plate fixing effect is reduced due to the corrosion of springs in water, ensuring the stability of the container, further reducing errors in the experimental process, and effectively solving the problems in the background technology.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a biological sample preparation auxiliary device, including a box, a microcontroller is provided at the front end of the box and the input end of the microcontroller is electrically connected to an external power supply, a placement groove is provided in the middle of the upper end of the box, a cavity is provided on the upper side of the inner part of the box, an electric heating wire is provided on the lower side of the inner part of the box and the input end of the electric heating wire is electrically connected to the output end of the microcontroller, a drain pipe is provided in the drain outlet opened on the lower side of the front end of the box, a drain valve is connected in series on the front side of each of the two drain pipes, and a fixing mechanism is also included;

[0006] The fixing mechanism includes clamping plates, connecting plates, and a driving assembly. The connecting plates are slidably connected to the sliding grooves opened on the left and right sides of the inner arc surface of the placement groove. Clamping plates are provided on the inner ends of the two connecting plates, and the outer arc surfaces of the two clamping plates are in contact with the inner arc surface of the placement groove. The driving assembly is located inside the cavity. The clamping plates are driven by the driving assembly. Through the cooperation of the mounting plate and the driving rod, the two clamping plates can be moved. Finally, the clamping plates fix the container, replacing the traditional method of moving the clamping plates by springs.

[0007] Furthermore, the fixing mechanism also includes mounting plates and crossbars. The mounting plates are respectively located at the ends of the connecting plate away from the center of the box. Both mounting plates have drive grooves in the middle of their upper ends. The crossbars are respectively located on the front and rear sides inside the cavity. The two crossbars are slidably connected to the sliding holes opened on the front and rear sides of the left end of the mounting plates. The mounting plates are installed in conjunction with the drive assembly, which can drive the clamping plate to move.

[0008] Furthermore, the drive assembly includes a mounting ring, a horizontal plate, a drive rod, a worm gear, a servo motor, and a worm. The mounting ring is rotatably connected to the upper side of the inner arc surface of the cavity. A horizontal plate is respectively provided on the lower side of the outer arc surface of the mounting ring. A drive rod is respectively provided at the lower end of the horizontal plate. The lower ends of the drive rods are respectively located inside the vertically adjacent drive slots. A worm gear is provided on the upper side of the outer arc surface of the mounting ring. The servo motor is located on the right side of the rear wall of the cavity. A worm is provided at the front end of the output shaft of the servo motor. The worm gear and the worm are meshed and connected. The input end of the servo motor is electrically connected to the output end of the microcontroller, which can drive the mounting plate to move.

[0009] Furthermore, it also includes a laser rangefinder, which is located on the front side of the right end of the left mounting plate. The laser rangefinder is situated between the rear end of the front crossbar and the front end of the left connecting plate. The laser rangefinder is bidirectionally electrically connected to the microcontroller and can detect the distance between the two mounting plates.

[0010] Furthermore, temperature detectors are respectively installed on the upper and lower sides of the front end of the box. The probes of the two temperature detectors are located inside the box. The lower temperature detector is located between the two drain pipes near the center of the box. The temperature detectors are bidirectionally electrically connected to the microcontroller and can detect the temperature of the water.

[0011] Furthermore, the interior of the box is equipped with a limiting plate, and the electric heating wires are all located on the lower side of the limiting plate. The limiting plate can prevent the container from contacting the electric heating wires.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] By using a mounting plate and a drive rod, two clamping plates can be moved to fix the container in place. This replaces the traditional method of using springs to move the clamping plates, solving the problem of reduced clamping effectiveness due to spring corrosion in water. This ensures the stability of the container and further reduces errors during the experiment. Attached Figure Description

[0014] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0015] Figure 2This is a schematic diagram of the front sectional structure of the present invention;

[0016] Figure 3 This is a schematic cross-sectional view of the right side of this utility model;

[0017] Figure 4 This is a schematic diagram of the fixing mechanism of this utility model;

[0018] Figure 5 This is an enlarged structural diagram of point A in this utility model.

[0019] In the diagram: 1. Housing, 2. Microcontroller, 3. Placement slot, 4. Cavity, 5. Fixing mechanism, 51. Clamping plate, 52. Connecting plate, 53. Mounting plate, 54. Crossbar, 55. Drive assembly, 551. Mounting ring, 552. Horizontal plate, 553. Drive rod, 554. Worm gear, 555. Servo motor, 556. Worm, 6. Heating wire, 7. Limiting plate, 8. Temperature detector, 9. Drain pipe, 10. Laser rangefinder. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Please see Figure 1-5 This embodiment provides a technical solution: a biological sample preparation auxiliary device, including a box 1. A microcontroller 2 is provided at the front end of the box 1, and the input end of the microcontroller 2 is electrically connected to an external power supply for regulating the electrical components inside the device. A placement slot 3 is provided in the middle of the upper end of the box 1. A cavity 4 is provided on the upper side inside the box 1. An electric heating wire 6 is provided on the lower side inside the box 1, and the input end of the electric heating wire 6 is electrically connected to the output end of the microcontroller 2. Drainage pipes 9 are respectively provided in the drain outlets opened on the lower side of the front end of the box 1. Drainage valves are connected in series on the front side of each of the two drain pipes 9. The electric heating wire 6 heats the water. The electric heating wire 6 is a nickel-chromium alloy heating wire with high resistivity, which can heat up rapidly after being energized.

[0022] It also includes a fixing mechanism 5; the fixing mechanism 5 includes a clamping plate 51, a connecting plate 52 and a driving assembly 55. The connecting plate 52 is slidably connected to the sliding grooves opened on the left and right sides of the inner arc surface of the placement groove 3. The two connecting plates 52 are each provided with a clamping plate 51 on their opposite inner ends. The outer arc surfaces of the two clamping plates 51 are in contact with the inner arc surface of the placement groove 3. The driving assembly 55 is located inside the cavity 4, and the clamping plates 51 are driven by the driving assembly 55. The fixing mechanism 5 also includes a mounting plate 53 and a crossbar 54. The mounting plate 53 is respectively located at the end of the connecting plate 52 away from the center of the box 1. The middle part of the upper end of the two mounting plates 53 is driven by a groove. The crossbar 54 is respectively located on the front and rear sides inside the cavity 4. The two crossbars 54 are slidably connected to the sliding holes opened on the front and rear sides of the left end of the mounting plate 53. The mounting plate 53 is installed in conjunction with the driving assembly 55.

[0023] The drive assembly 55 includes a mounting ring 551, a horizontal plate 552, a drive rod 553, a worm gear 554, a servo motor 555, and a worm 556. The mounting ring 551 is rotatably connected to the upper side of the inner arc surface of the cavity 4. The lower side of the outer arc surface of the mounting ring 551 is provided with a horizontal plate 552. The lower end of the horizontal plate 552 is provided with a drive rod 553. The lower ends of the drive rods 553 are located inside the vertically adjacent drive slots. The upper side of the outer arc surface of the mounting ring 551 is provided with a worm gear 554. The servo motor 555 is located on the right side of the rear wall of the cavity 4. The front end of the output shaft of the servo motor 555 is provided with a worm 556. The worm gear 554 is meshed with the worm 556. The input end of the servo motor 555 is electrically connected to the output end of the microcontroller 2.

[0024] It also includes a laser rangefinder 10, which is located on the front side of the right end of the mounting plate 53 on the left side. The laser rangefinder 10 is located between the rear end of the front crossbar 54 and the front end of the left connecting plate 52. The laser rangefinder 10 is bidirectionally electrically connected to the microcontroller 2.

[0025] Temperature detectors 8 are installed on the upper and lower sides of the front end of the housing 1. The probes of the two temperature detectors 8 are located inside the housing 1. The lower temperature detector 8 is located between the two drain pipes 9 near the center of the housing 1. The temperature detectors 8 are bidirectionally electrically connected to the microcontroller 2.

[0026] Among them: the interior of the box 1 is equipped with a limiting plate 7, and the electric heating wires 6 are all located on the lower side of the limiting plate 7. The limiting plate 7 can prevent the container from contacting the electric heating wires 6.

[0027] The working principle of this utility model is as follows:

[0028] Before use, add enough water to the inside of the box 1 through the placement slot 3 according to the actual situation. After the water is added, the operator measures the radius of the placement slot 3 and the container (test tube, beaker, reaction bottle) (e.g., a and b), and then measures the width of the clamping plate 51 and the laser rangefinder 10 (e.g., c and d). Then, measure the distance between the two mounting plates 53 through the laser rangefinder 10.

[0029] During use, the laser rangefinder 10 reflects light after contacting the left end of the mounting plate 53 on the right side. The laser rangefinder 10 then receives the reflected light. The laser rangefinder 9 calculates the distance (e) between the right end of the laser rangefinder 10 and the left end of the mounting plate 53 by measuring the round-trip time (TOF) or phase difference. This distance is then added to the width of the laser rangefinder 10 to obtain the distance between the two mounting plates 53 (f = d + e). Subsequently, the laser rangefinder 10 transmits the detected information to the microcontroller 2 via its built-in data transmission module. The microcontroller 2 receives the detected data through its built-in serial communication port. Dividing the distance between the two mounting plates 53 by 2 gives the distance between the mounting plate 53 and the center of the mounting groove 3 (e.g., g, g = f ÷ 2). Subtracting the radius of the container and the thickness of the clamping plate 51 from the radius of the placement groove 3 gives the distance between the inner arc surface of the clamping plate 51 and the outer arc surface of the container (e.g., h, h = abc). Subtracting the distance between the center of the mounting plate 53 and the center of the mounting groove 3 from the distance between the inner arc surface of the clamping plate 51 and the outer arc surface of the container, multiplying by 2, and then subtracting the width of the laser rangefinder 10 gives the distance between the right end of the laser rangefinder 10 and the left end of the right mounting plate 53 when the clamping plate 51 stops moving [e.g., i, i = (gh) × 2 - d];

[0030] In the subsequent use of the biological sample preparation auxiliary equipment, the operator passes the container containing the biological sample through the placement groove 3 and extends it into the interior of the box 1, so that the water submerges the lower end of the container. Then, under the control of the microcontroller 2, the servo motor 555 starts to run. The output shaft of the servo motor 555 drives the worm gear 556 to rotate. During the rotation of the worm gear 556, it drives the worm wheel 554 to rotate through the meshing connection. During the rotation of the worm wheel 554, it drives the horizontal plate 552 to rotate through the mounting ring 551. The horizontal plate 552 drives the drive rod 553 to rotate. At this time, the drive rod 553 slides inside the drive groove and rotates relative to the drive groove, so that the horizontal plate 552 drives the mounting plate 53 to move through the drive rod 553. During the movement of the mounting plate 53, it drives the clamping plate 51 to move through the connecting plate 52. At this time, the distance between the two clamping plates 51 will gradually decrease, and the distances moved by the two clamping plates 51 will be equal.

[0031] When the distance between the right end of the laser rangefinder 10 and the left end of the mounting plate 53 on the right side is equal to i, it means that the inner arc surface of the clamping plate 51 is in contact with the outer arc surface of the container, thereby achieving the limiting and fixing of the container, replacing the traditional method of moving the clamping plate 51 by means of a spring. This solves the problem that the fixing effect of the clamping plate 51 is reduced after the spring is corroded in water, ensuring the stability of the container and further reducing the error in the experimental process.

[0032] Subsequently, under the control of the microcontroller 2, the servo motor 555 stops running and the electric heating wire 6 starts running. The electric heating wire 6 is a nickel-chromium alloy heating wire with high resistivity, which can heat up quickly after being powered on. During the process of the electric heating wire 6 heating the water, two temperature detectors 8 collect the temperature signal of the precursor solution through thermistor sensors. The thermistor sensors convert the temperature change into the resistance value change. Then, the temperature detectors 8 convert the resistance value into the temperature value through the built-in algorithm. After that, the data calculated by the temperature detectors 8 is transmitted to the microcontroller 2. Then, the microcontroller 2 takes an intermediate value based on the data provided by the two sets of temperature detectors 8. This intermediate value is the temperature of the water.

[0033] Finally, maintain this temperature at around the set value. The heated water will transfer heat to the container, and then the container will transfer heat to the biological sample inside the container. This process can be used to heat, keep warm, dissolve, and react the biological sample.

[0034] It is worth noting that the microcontroller 2 disclosed in the above embodiments can be AT89C51, the servo motor 555 can be ECMA-C20604RS, the temperature detector 8 can be OHR-E700, and the laser rangefinder 10 can be HMLDM-UD100A. The microcontroller 2 controls the servo motor 555, the electric heating wire 6, the temperature detector 8, and the laser rangefinder 10 using methods commonly used in the prior art.

[0035] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A biological sample preparation auxiliary device, comprising a box (1), wherein a microcontroller (2) is provided at the front end of the box (1) and the input end of the microcontroller (2) is electrically connected to an external power supply, a placement slot (3) is provided in the middle of the upper end of the box (1), a cavity (4) is provided on the upper side inside the box (1), an electric heating wire (6) is provided on the lower side inside the box (1) and the input end of the electric heating wire (6) is electrically connected to the output end of the microcontroller (2), and a drain pipe (9) is provided in the drain outlet opened on the lower side of the front end of the box (1), and a drain valve is connected in series on the front side of each of the two drain pipes (9); Its features are: It also includes fixed mechanisms (5); The fixing mechanism (5) includes a clamping plate (51), a connecting plate (52) and a driving component (55). The connecting plate (52) is slidably connected to the sliding grooves opened on the left and right sides of the inner arc surface of the placement groove (3). The two connecting plates (52) are provided with clamping plates (51) on their opposite inner ends. The outer arc surfaces of the two clamping plates (51) are in contact with the inner arc surface of the placement groove (3). The driving component (55) is located inside the cavity (4). The clamping plates (51) are driven by the driving component (55).

2. The biological sample preparation auxiliary device according to claim 1, characterized in that: The fixing mechanism (5) also includes a mounting plate (53) and a crossbar (54). The mounting plate (53) is respectively located at one end of the connecting plate (52) away from the center of the box (1). The middle of the upper end of the two mounting plates (53) is a drive groove. The crossbar (54) is respectively located on the front and rear sides inside the cavity (4). The two crossbars (54) are slidably connected to the sliding holes opened on the front and rear sides of the left end of the mounting plate (53). The mounting plate (53) is installed in conjunction with the drive assembly (55).

3. The biological sample preparation auxiliary device according to claim 2, characterized in that: The drive assembly (55) includes a mounting ring (551), a horizontal plate (552), a drive rod (553), a worm gear (554), a servo motor (555), and a worm (556). The mounting ring (551) is rotatably connected to the upper side of the inner arc surface of the cavity (4). The lower side of the outer arc surface of the mounting ring (551) is provided with a horizontal plate (552). The lower end of the horizontal plate (552) is provided with a drive rod (553). The lower end of the drive rod (553) is located inside the vertically adjacent drive slots. The upper side of the outer arc surface of the mounting ring (551) is provided with a worm gear (554). The servo motor (555) is located on the right side of the rear wall of the cavity (4). The front end of the output shaft of the servo motor (555) is provided with a worm (556). The worm gear (554) and the worm (556) are meshed and connected. The input end of the servo motor (555) is electrically connected to the output end of the microcontroller (2).

4. The biological sample preparation auxiliary device according to claim 2, characterized in that: It also includes a laser rangefinder (10), which is located on the front side of the right end of the mounting plate (53) on the left side. The laser rangefinder (10) is located between the rear end of the crossbar (54) on the front side and the front end of the connecting plate (52) on the left side. The laser rangefinder (10) is bidirectionally electrically connected to the microcontroller (2).

5. The biological sample preparation auxiliary device according to claim 1, characterized in that: Temperature detectors (8) are respectively installed on the upper and lower sides of the front end of the box (1). The probes of the two temperature detectors (8) are located inside the box (1). The temperature detector (8) on the lower side is located between the two drain pipes (9) near the center of the box (1). The temperature detectors (8) are bidirectionally electrically connected to the microcontroller (2).

6. The biological sample preparation auxiliary device according to claim 1, characterized in that: The box (1) is equipped with a limiting plate (7) inside, and the electric heating wires (6) are all located on the lower side of the limiting plate (7).

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