A dry heat sterilization device for vials

Abstract

This utility model discloses a vial dry heat sterilization device in the field of freeze-dried powder injection production equipment. It includes a chassis and a control unit within the chassis, a conveying unit and a housing on the chassis, a preheating chamber, a dry heat sterilization chamber, a cooling chamber, and a temperature sensor within the housing. It also includes a hot air generation unit and a cold air generation unit on the housing. The preheating chamber has a duct, and a guide plate connects to the bottom of the duct. The bottom plate of the guide plate has several evenly distributed exhaust holes, and several exhaust pipes are arranged in an array below the guide plate. Several evenly distributed vertical exhaust ports are opened on the wall of the exhaust pipes. An external air source is connected to the duct. This vial dry heat sterilization device, through the cooperation of the guide plate and exhaust pipes, achieves the effect of loosely packed vials and conveying hot airflow to the surrounding area of ​​the vials, thereby achieving rapid and uniform preheating of the vials.

Description

Technical Field

[0001] This utility model relates to the field of freeze-dried powder injection production equipment, specifically to a vial dry heat sterilization device. Background Technology

[0002] In the production of lyophilized powder injections, the vials need to be sterilized before filling them with the medication. Common sterilization methods include dry heat sterilization and moist heat sterilization. Dry heat sterilization achieves sterilization by drying air at high temperatures, effectively killing microorganisms and removing pyrogens. It has advantages such as not introducing moisture, no residue risk, and applicability to a wide variety of materials, making it the preferred process for vial sterilization in the production of lyophilized powder injections. During dry heat sterilization, a preheating zone is needed before the sterilization zone to prevent vials from breaking due to thermal shock. However, in actual production, vials are often piled up on the conveyor belt, with adjacent vials directly touching each other. The contact areas cannot be evenly contacted with the airflow, leading to uneven heating and increasing the probability of vial breakage. To address this, this invention proposes a dry heat sterilization device for vials. Utility Model Content

[0003] The purpose of this invention is to provide a dry heat sterilization device for vials in order to solve the above-mentioned problems.

[0004] This utility model achieves the above objectives through the following technical solutions: This utility model provides a vial dry heat sterilization device, including a chassis and a control unit located inside the chassis, a conveying unit and a housing located on the chassis, a preheating chamber, a dry heat sterilization chamber, a cooling chamber, and a first temperature sensor located inside the housing, a hot air generating unit and a cold air generating unit located on the housing. The preheating chamber is equipped with a wind duct, and a guide plate is connected to the bottom of the wind duct. The bottom plate of the guide plate has several evenly distributed exhaust holes, and several exhaust pipes are arranged in an array below the guide plate. Several evenly distributed vertical exhaust ports are opened on the wall of the exhaust pipes, and a guide pipe for connecting an external air source is provided on the wind duct.

[0005] As a further optimization of this utility model, a passive gear and a driving gear are meshed and connected above the air guide plate. The passive gear is sleeved on the air duct, the driving gear is missing a gear and the teeth are evenly distributed, and the passive gear is elastically rotatably connected to the air duct.

[0006] As a further optimization of this utility model, the passive gear is provided with a number of sliding grooves arranged in a ring array, and the outer side of the air duct is provided with a number of side rods corresponding to the sliding grooves one by one. The ends of the side rods are located in the sliding grooves and are elastically slidably connected to the sliding grooves through springs in the sliding grooves.

[0007] As a further optimization of this utility model, both sides of the dry heat sterilization chamber and the cooling chamber are provided with air hoods, and the air hoods are connected to the air ducts through control valves.

[0008] As a further optimization of this utility model, the air duct is provided with a honeycomb structure packing, and a second temperature sensor is provided on the air duct, with the probe of the second temperature sensor extending below the packing.

[0009] As a further optimization of this utility model, both the dry heat sterilization chamber and the cooling chamber are equipped with mesh plates, which have a double-layer structure and the mesh holes of the two layers are staggered.

[0010] The beneficial effects of this utility model are as follows: The vial dry heat sterilization device proposed in this utility model is equipped with an air guide plate and an exhaust pipe in the preheating chamber. The exhaust pipe is located on the necessary path of the vials. As the vials pass through the preheating chamber, the exhaust pipe will insert between the vials, separating the tightly packed vials to achieve the effect of loosely stacked vials. The airflow output through the exhaust holes on the air guide plate and the exhaust pipe can be blown onto the vials from all directions, achieving the effect of comprehensive and uniform heating of the vials. This comprehensively improves the preheating efficiency and enhances the preheating uniformity. Attached Figure Description

[0011] Figure 1 This is a schematic diagram of the overall appearance of the present utility model; Figure 2 This is a cross-sectional view of the internal structure of the casing; Figure 3 A schematic diagram showing the connection between the air duct, air guide plate, and exhaust pipe; Figure 4 This is a cross-sectional view of the internal structure of the ventilation duct.

[0012] In the diagram: 1. Chassis; 2. Conveying unit; 3. Housing; 4. Temperature sensor No. 1; 5. Air guide plate; 6. Exhaust duct; 7. Driven gear; 8. Air duct; 9. Slide rail; 10. Side rod; 11. Spring; 12. Driven gear; 13. Air guide duct; 14. Packing; 15. Temperature sensor No. 2; 16. Air cover; 17. Mesh plate; 18. Hot air generation unit; 19. Cold air generation unit. Detailed Implementation

[0013] The present application will now be described in further detail with reference to the accompanying drawings. It should be noted that the following specific embodiments are only used to further illustrate the present application and should not be construed as limiting the scope of protection of the present application. Those skilled in the art can make some non-essential improvements and adjustments to the present application based on the above application content.

[0014] Example 1 like Figure 1-4As shown, the vial dry heat sterilization equipment of this embodiment includes a chassis 1 and a control unit disposed in the chassis 1, a conveying unit 2 disposed on the chassis 1 and a housing 3. The housing 3 is provided with a preheating chamber, a dry heat sterilization chamber and a cooling chamber arranged sequentially along the conveying direction of the conveying unit 2. A first temperature sensor 4 is provided in the dry heat sterilization chamber and the cooling chamber respectively. The housing 3 is provided with a hot gas generating unit 18 for inputting high temperature gas into the dry heat sterilization chamber and a cold gas generating unit 19 for inputting cold gas into the cooling chamber. The above features are all direct references to the corresponding structures or functional modules in existing dry heat sterilization equipment, and no specific limitations are made here. The preheating chamber is equipped with a duct 8, and the bottom of the duct 8 is connected to a guide plate 5. The bottom plate of the guide plate 5 has several evenly distributed exhaust holes, and the bottom of the guide plate 5 has several exhaust pipes 6 arranged in an array. The wall of the exhaust pipes 6 has several evenly distributed vertical exhaust ports. The duct 8 is equipped with a guide pipe 13 for connecting to an external air source.

[0015] The working process of the vial dry heat sterilization equipment is as follows: the vials to be processed are placed on the conveying unit 2 by manual or mechanical means. The conveying unit 2 drives the vials to pass through the preheating chamber, the dry heat sterilization chamber and the cooling chamber in sequence before being output. During the process of the vials passing through the preheating chamber, the vials must pass between the exhaust pipes 6. On the one hand, the stacked vials will be pushed apart by the exhaust pipes 6, leaving gaps between adjacent vials, which is conducive to the uniform contact of the vials with the airflow during the preheating, dry heat sterilization and cooling processes. On the other hand, the gas output through the exhaust holes and exhaust pipes 6 can surround the vials, making them heat up evenly and achieving the effect of rapid preheating.

[0016] As a further optimization of this embodiment, a passive gear 7 and a driving gear 12 are meshed and connected above the air guide plate 5. The passive gear 7 is sleeved on the air duct 8, and the driving gear 12 is missing a gear and the teeth are evenly distributed. The passive gear 7 is elastically rotatably connected to the air duct 8. The passive gear 7 is provided with several sliding grooves 9 arranged in a circular array. The outer side of the air duct 8 is provided with several side rods 10 that correspond one-to-one with the sliding grooves 9. The ends of the side rods 10 are located in the sliding grooves 9 and are elastically slidably connected to the sliding grooves 9 through springs 11 in the sliding grooves 9. During the continuous rotation of the drive gear 12, when the drive gear 12 meshes with the driven gear 7, the drive gear 12 can drive the entire assembly consisting of the driven gear 7, the slide groove 9, the air guide plate 5, and the exhaust pipe 6 to rotate, compressing the spring 11 in the slide groove 9. Subsequently, the missing tooth of the drive gear 12 aligns with the driven gear 7, and the drive gear 12 no longer applies force to the driven gear 7. Under the action of the spring 11, the entire assembly consisting of the driven gear 7, the slide groove 9, the air guide plate 5, and the exhaust pipe 6 rotates. Then, the subsequent teeth on the drive gear 12 re-mesh with the driven gear 7, and the above steps are repeated. This achieves the effect of driving the entire assembly consisting of the air guide plate 5 and the exhaust pipe 6 to swing slightly, allowing the exhaust pipe 6 to be inserted between the vials that are being continuously moved by the conveying unit 2 to achieve the effect of loosening the vials and avoiding the problem of the stacked vials being blocked by the exhaust pipe 6. It should be emphasized that the oscillation amplitude and frequency of the whole formed by the connection of the air guide plate 5 and the exhaust pipe 6 are determined by the number of teeth of the driving gear 12 and the driven gear 7. The design should be based on the size of the vial being processed, and no specific restrictions are made here.

[0017] As a further optimization of this embodiment, both sides of the dry heat sterilization chamber and the cooling chamber are provided with air hoods 16, and the air hoods 16 are connected to the air ducts 13 through control valves. The air duct 8 is equipped with a honeycomb structure packing 14, and a second temperature sensor 15 is installed on the air duct 8, with the probe of the second temperature sensor 15 extending below the packing 14. The high-temperature airflow in the heat sterilization chamber and the low-temperature airflow in the cooling chamber are introduced into the air duct 8 through the air guide duct 13. They are further mixed as they pass through the honeycomb structure packing 14 and continue to be conveyed downwards for preheating the vials. During this process, the ventilation efficiency of the two control valves is adjusted according to the temperature monitored by the second temperature sensor 15, thereby adjusting the ratio of hot and cold gases, and then adjusting the temperature of the mixed gas to meet the preheating requirements. It should be emphasized that the temperature of the mixed gas used for preheating does not need to be controlled to a precise temperature, but only within a reasonable range. The general requirement is 80-120℃. The specific temperature range needs to be confirmed according to the preheating time, and no specific limit is made here.

[0018] As a further optimization of this embodiment, both the dry heat sterilization chamber and the cooling chamber are equipped with mesh plates 17. The mesh plates 17 have a double-layer structure and the mesh holes of the two layers are staggered. The double-layer mesh plates 17 can play a diversion effect, so that the airflow can be evenly distributed in the dry heat sterilization chamber and the cooling chamber, and the vials at each position on the conveying unit 2 can be evenly contacted by the airflow.

[0019] The embodiments described above are merely examples of several implementations of this utility model, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these modifications and improvements all fall within the protection scope of this utility model.

Claims

1. A vial dry heat sterilization device, comprising a chassis (1) and a control unit disposed within the chassis (1), a conveying unit (2) and a housing (3) disposed on the chassis (1), a preheating chamber, a dry heat sterilization chamber, a cooling chamber disposed within the housing (3), a first temperature sensor (4), a hot air generating unit (18) and a cold air generating unit (19) disposed on the housing (3), characterized in that: The preheating chamber is provided with a duct (8), and the bottom of the duct (8) is connected to a guide plate (5). The bottom plate of the guide plate (5) is provided with a number of evenly distributed exhaust holes, and the bottom of the guide plate (5) is provided with a number of arrayed exhaust pipes (6). The wall of the exhaust pipes (6) is provided with a number of evenly distributed vertical exhaust ports, and the duct (8) is provided with an air guide pipe (13) for connecting to an external air source.

2. The vial dry heat sterilization device according to claim 1, characterized in that: The air guide plate (5) is provided with a meshing passive gear (7) and a driving gear (12) above it. The passive gear (7) is sleeved on the air duct (8). The driving gear (12) is missing a gear and the teeth are evenly distributed. The passive gear (7) is elastically rotatably connected to the air duct (8).

3. The vial dry heat sterilization device according to claim 2, characterized in that: The passive gear (7) is provided with a number of sliding grooves (9) arranged in a ring array. The outer side of the air duct (8) is provided with a number of side rods (10) corresponding to the sliding grooves (9). The end of the side rod (10) is located in the sliding groove (9) and is elastically slidably connected to the sliding groove (9) by a spring (11) in the sliding groove (9).

4. The vial dry heat sterilization equipment according to claim 1, characterized in that: Both sides of the dry heat sterilization chamber and the cooling chamber are provided with air hoods (16), and the air hoods (16) are connected to the air ducts (13) through control valves.

5. The vial dry heat sterilization device according to claim 1, characterized in that: The air duct (8) is provided with a honeycomb structure packing (14), and a second temperature sensor (15) is provided on the air duct (8), with the probe of the second temperature sensor (15) extending below the packing (14).

6. The vial dry heat sterilization device according to claim 1, characterized in that: Both the dry heat sterilization chamber and the cooling chamber are equipped with mesh plates (17), which have a double-layer structure and the mesh holes of the two layers are staggered.

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