A vaccine adjuvant filtration device

Abstract

The utility model discloses a vaccine adjuvant filtering device belongs to vaccine adjuvant production technical field, include: filter box and install cover, the material guide frame is set up in the installation cover bottom, the installation cover sets up on the filter box upper end, the material guide frame is round table state setting, the material guide frame bottom is equipped with the mounting sleeve, the utility model discloses, can when vaccine adjuvant enters the device, the rotation feed plate makes liquid produce circumferential diffusion through centrifugal force effect, and the flexible shower nozzle breaks the fluid unidirectionality in the multidirectional injection mode, and the spiral material guide plate is used for three -dimensional space regulation and control to adjuvant flow, finally realizes the spiral even distribution of adjuvant in the filter cavity, makes adjuvant no longer concentrated impact filter screen local area, but forms the stable flow field that covers entire filter screen effective area, has prolonged the filter material life, has guaranteed the persistence stability of filtration efficiency, makes the practicality of vaccine adjuvant filtering device use better.

Description

Technical Field

[0001] This utility model belongs to the field of vaccine adjuvant production technology, specifically relating to a vaccine adjuvant filtration device. Background Technology

[0002] Vaccine adjuvant filtration devices are key equipment in vaccine production for the purification and treatment of adjuvants. They remove impurities and microorganisms through physical retention or multiple filtration mechanisms, ensuring the purity and safety of the adjuvant. Their core principles include multi-stage filtration and tangential flow technology. Vaccine adjuvant filtration devices remove particulate matter, endotoxins, and microorganisms from adjuvants, preventing impurities from interfering with the immune response. Compatibility testing ensures that the filter material does not release leachates or adsorb active ingredients. Applications of vaccine adjuvant filtration devices cover the production of animal inactivated vaccines and recombinant protein vaccines, playing a particularly crucial role in the purification of oily or aqueous adjuvants such as white oil adjuvants and aluminum adjuvants.

[0003] In practical use, this utility model generally adopts a filter structure to purify adjuvants. However, the feed inlet of existing vaccine adjuvant filtration devices is usually fixed. This static feeding method causes the vaccine adjuvant fluid to continuously and concentratedly impact a specific area of ​​the filter during the filtration stage, resulting in a local filtration load that far exceeds the design threshold, while other areas are in a state of inefficient utilization for a long time. This not only causes significant differences in the degree of wear of different areas of the filter, but also directly leads to the formation of non-uniform contamination deposits on the surface of the filter medium. Ultimately, this results in practical defects such as fluctuations in filtration efficiency and shortened filter media life during continuous production. Utility Model Content

[0004] This invention provides a vaccine adjuvant filtration device to address the problem of uneven entry of vaccine adjuvants into the filtration device in existing technologies.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a vaccine adjuvant filtration device, comprising:

[0006] Filter box and mounting cover;

[0007] A guide frame is provided at the bottom of the mounting cover, which is located at the top of the filter box. The guide frame is shaped like a frustum and has a mounting sleeve at its bottom.

[0008] A filter cartridge is disposed at the bottom end of the mounting sleeve. The bottom end of the mounting cover is provided with a feed plate. A water storage tank is provided inside the feed plate. The upper end of the feed plate is provided with a mounting shaft. The upper end of the mounting shaft passes through the mounting cover and extends to the outside.

[0009] A drive shaft is located at the bottom of the feed plate, and the bottom end of the drive shaft passes through the filter cylinder. A filter plate is provided at the bottom of the filter box, and a discharge pipe is provided on one side of the bottom of the filter box.

[0010] To ensure that the vaccine adjuvant can enter the filtration device evenly, the feed plate is further provided with a filter layer, and the bottom of the feed plate is provided with multiple discharge ports. Mounting plates are provided on both sides of the multiple discharge ports, and the same nozzle is rotatably connected between two mounting plates on the same side. Telescopic tubes are provided between the discharge ports and the nozzles on the same side.

[0011] In a preferred embodiment, the mounting shaft passes through a feed trough that is connected to a water storage tank, and a matching feed pipe is rotatably connected to the upper end of the feed trough.

[0012] In a preferred embodiment, a drive motor is provided on one side of the upper end of the mounting cover, a drive wheel is provided at the output end of the drive motor, and an external toothed ring that meshes with the drive wheel is provided on the outer side of the mounting shaft.

[0013] In a preferred embodiment, the upper end of the feed plate is provided with a snap-fit ​​ring with a "T" shaped cross-section, and the bottom end of the mounting cover is provided with a snap-fit ​​groove that matches the snap-fit ​​ring. The snap-fit ​​ring is located in the snap-fit ​​groove and is slidably connected to the side wall of the snap-fit ​​groove.

[0014] In a preferred embodiment, the inner wall of the mounting sleeve is provided with multiple guide plates, all of which are arranged in a spiral shape.

[0015] In a preferred embodiment, a plurality of stirring blades are provided on the outside of the drive shaft located inside the filter cylinder, and the plurality of stirring blades are arranged in a ring around the central axis of the drive shaft.

[0016] To ensure the effectiveness of the filtration device in filtering vaccine adjuvants, a plurality of matching first cleaning brushes are further provided on the outside of the drive shaft located inside the filter cylinder. One side of each of the plurality of first cleaning brushes abuts against the inner wall of the filter cylinder. A second cleaning brush is provided at the bottom end of the drive shaft, and the bottom end of the second cleaning brush abuts against the upper end of the filter plate.

[0017] Compared with the prior art, the beneficial effects of this utility model are:

[0018] 1. This utility model, through a rotatable feed plate set in the filter device and multiple bendable nozzles at its bottom, combined with multiple spiral guide plates in the mounting sleeve, allows the liquid to be diffused circumferentially by the centrifugal force when the vaccine adjuvant enters the device. At the same time, the bendable nozzles break the unidirectional fluid flow by multi-directional spraying. Combined with the spiral guide plates, the flow direction of the adjuvant is controlled in three-dimensional space, ultimately achieving a spiral uniform distribution of the adjuvant in the filter chamber. This prevents the adjuvant from concentrating on impacting local areas of the filter screen, but instead forms a stable flow field covering the entire effective area of ​​the filter screen. This not only extends the service life of the filter material but also ensures the continuous stability of the filtration efficiency, making the vaccine adjuvant filtration device more practical.

[0019] 2. This utility model, through multiple first cleaning brushes set on the outside of the drive shaft and a second cleaning brush at the bottom, can conveniently and effectively clean the inner wall of the filter cylinder and the surface of the filter plate when the drive shaft rotates, ensuring that the pore channels are unobstructed. It can not only remove potential blockages in real time, but also prevent particulate matter from forming a dense deposit layer on the surface of the filter material, thereby providing a stable and efficient power guarantee for vaccine adjuvant production and significantly improving the reliability of large-scale industrial filtration. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the main appearance of the structure of this utility model;

[0021] Figure 2 This is a schematic front cross-sectional view of the structure of this utility model;

[0022] Figure 3 This is a schematic diagram showing the connection between the discharge port, mounting plate, and nozzle of this utility model.

[0023] Figure 4 for Figure 2 A magnified schematic diagram of the structure at point A in the middle.

[0024] In the diagram: 1. Filter box; 2. Mounting cover; 3. Material guide frame; 4. Mounting sleeve; 5. Filter cylinder; 6. Feed plate; 7. Mounting shaft; 8. Drive shaft; 9. Filter plate; 10. Discharge pipe; 11. Filter layer; 12. Discharge port; 13. Mounting plate; 14. Nozzle; 15. Telescopic pipe; 16. Feed pipe; 17. Drive motor; 18. Drive wheel; 19. External gear ring; 20. Snap ring; 21. Material guide plate; 22. Agitator blade; 23. First cleaning brush; 24. Second cleaning brush. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0026] Example 1:

[0027] Please see Figure 1-4 This utility model provides a vaccine adjuvant filtration device, comprising:

[0028] Filter box 1 and mounting cover 2;

[0029] The guide frame 3 is located at the bottom of the mounting cover 2, which is located at the top of the filter box 1. The guide frame 3 is shaped like a frustum, and the bottom of the guide frame 3 is provided with a mounting sleeve 4.

[0030] The filter cartridge 5 is located at the bottom of the mounting sleeve 4. The bottom of the mounting cover 2 is provided with a feed plate 6. A water storage tank is opened inside the feed plate 6. The upper end of the feed plate 6 is provided with a mounting shaft 7. The upper end of the mounting shaft 7 passes through the mounting cover 2 and extends to the outside.

[0031] The drive shaft 8 is located at the bottom of the feed plate 6. The bottom of the drive shaft 8 passes through the filter cylinder 5. The bottom of the filter box 1 is provided with a filter plate 9. The bottom side of the filter box 1 is provided with a discharge pipe 10.

[0032] Specifically, such as Figure 2 and Figure 3 As shown, the feed plate 6 is provided with a filter layer 11, and the bottom of the feed plate 6 is provided with multiple discharge ports 12. The multiple discharge ports 12 are provided with mounting plates 13 on both sides. The same nozzle 14 is rotatably connected between two mounting plates 13 on the same side. The discharge ports 12 and the nozzle 14 on the same side are provided with telescopic tubes 15.

[0033] Through its design, the filter layer 11 inside the feed plate 6 can perform initial filtration of particulate matter in the vaccine adjuvant. When the feed plate 6 rotates, it will drive multiple discharge ports 12 and multiple nozzles 14 to rotate. The vaccine adjuvant in the feed plate 6 can be evenly entered into the filter box 1 through centrifugal force. The multiple rotatable nozzles 14 can be bent into different angles according to the rotation speed of the feed plate 6, which further improves the uniformity of vaccine adjuvant entry. The telescopic tube 15 can also allow the nozzles 14 to rotate without affecting the transmission of vaccine adjuvant.

[0034] Specifically, such as Figure 2 and Figure 4 As shown, the mounting shaft 7 passes through the feed trough which is connected to the water storage tank. The upper end of the feed trough is rotatably connected to a matching feed pipe 16. The feed pipe 16, located in the feed trough, can inject vaccine adjuvants without affecting the rotation of the mounting shaft 7. The feed pipe 16 is connected to an external container for storing vaccine adjuvants and can inject the vaccine adjuvants to be filtered into the filter box 1.

[0035] Specifically, such as Figure 2 and Figure 4 As shown, a drive motor 17 is provided on one side of the upper end of the mounting cover 2. The drive motor 17 is existing technology and will not be described in detail here. The output end of the drive motor 17 is provided with a drive wheel 18. An external gear ring 19 that meshes with the drive wheel 18 is provided on the outside of the mounting shaft 7. When the drive motor 17 is started, its output end will drive the drive wheel 18 to rotate, thereby driving the external gear ring 19 and the mounting shaft 7 to rotate.

[0036] Specifically, such as Figure 2 and Figure 4As shown, the upper end of the feed plate 6 is provided with a snap ring 20 with a "T" shaped cross-section, and the bottom end of the mounting cover 2 is provided with a snap groove that matches the snap ring 20. The snap ring 20 is located in the snap groove and is slidably connected to the side wall of the snap groove. Through the snap ring 20 with a "T" shaped cross-section and the snap groove, the position of the feed plate 6 can be limited without affecting its rotation, thus ensuring stability during use.

[0037] Specifically, such as Figure 2 As shown, the inner wall of the mounting sleeve 4 is provided with multiple guide plates 21, all of which are spirally arranged. The multiple spiral guide plates 21 in the mounting sleeve 4 can guide the flow of vaccine adjuvant, so that it can be further distributed in the filter box 1, ensuring the filtration effect of the filter box 1 on vaccine adjuvant.

[0038] Specifically, such as Figure 2 As shown, multiple stirring blades 22 are provided on the outside of the drive shaft 8 located inside the filter cylinder 5. The multiple stirring blades 22 are arranged in a ring around the central axis of the drive shaft 8. The multiple stirring blades 22 can agitate the vaccine adjuvant, thereby improving its filtration effect.

[0039] Example 2:

[0040] Please see Figure 1-4 This utility model provides a vaccine adjuvant filtration device, comprising:

[0041] Filter box 1 and mounting cover 2;

[0042] The guide frame 3 is located at the bottom of the mounting cover 2, which is located at the top of the filter box 1. The guide frame 3 is shaped like a frustum, and the bottom of the guide frame 3 is provided with a mounting sleeve 4.

[0043] The filter cartridge 5 is located at the bottom of the mounting sleeve 4. The bottom of the mounting cover 2 is provided with a feed plate 6. A water storage tank is opened inside the feed plate 6. The upper end of the feed plate 6 is provided with a mounting shaft 7. The upper end of the mounting shaft 7 passes through the mounting cover 2 and extends to the outside.

[0044] The drive shaft 8 is located at the bottom of the feed plate 6. The bottom of the drive shaft 8 passes through the filter cylinder 5. The bottom of the filter box 1 is provided with a filter plate 9. The bottom side of the filter box 1 is provided with a discharge pipe 10.

[0045] Specifically, such as Figure 2 As shown, a plurality of matching first cleaning brushes 23 are provided on the outside of the drive shaft 8 located inside the filter cylinder 5. One side of each of the plurality of first cleaning brushes 23 abuts against the inner wall of the filter cylinder 5. A second cleaning brush 24 is provided at the bottom of the drive shaft 8, and the bottom of the second cleaning brush 24 abuts against the upper end of the filter plate 9.

[0046] Its design allows the drive shaft 8 to rotate, which in turn drives the multiple first cleaning brushes 23 on the outside and the second cleaning brushes 24 at the bottom to rotate, thus facilitating the cleaning of the filter cylinder 5 and the filter plate 9, preventing particulate matter from clogging them, and ensuring the efficiency of the filtration device in filtering vaccine adjuvants.

[0047] See Figure 1-4 When using a filtration device to filter vaccine adjuvants, the vaccine adjuvants are first introduced into the feed plate 6 through the feed pipe 16. Then, the drive motor 17 is started, driving the drive wheel 18 to rotate. The drive wheel 18 drives the external gear ring 19 and the mounting shaft 7 to rotate. The mounting shaft 7 then drives the feed plate 6 and multiple nozzles 14 to rotate. Centrifugal force is used to evenly distribute the vaccine adjuvants in the feed plate 6 into the guide frame 3. The vaccine adjuvants in the guide frame 3 flow into the mounting sleeve 4. Multiple spiral guide plates 21 within the mounting sleeve 4 further guide the vaccine adjuvants. The flow direction is adjusted to ensure more even distribution of the vaccine adjuvant. The adjuvant enters the filter cartridge 5 for further filtration. The filtered adjuvant falls onto the bottom filter plate 9, which can then filter it again. The filtered adjuvant is discharged through the discharge pipe 10. When the feed plate 6 rotates, it also drives the drive shaft 8 to rotate. The drive shaft 8 drives multiple first cleaning brushes 23 and the bottom second cleaning brush 24 to rotate, thus facilitating the cleaning of the filter cartridge 5 and filter plate 9 and ensuring the efficiency of the filtration device in filtering the vaccine adjuvant.

[0048] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A vaccine adjuvant filtration device, characterized in that, include: Filter box (1) and mounting cover (2); A guide frame (3) is set at the bottom of the mounting cover (2), which is set at the top of the filter box (1). The guide frame (3) is set in the shape of a frustum, and the bottom of the guide frame (3) is provided with a mounting sleeve (4). A filter cartridge (5) is set at the bottom of the mounting sleeve (4). The bottom of the mounting cover (2) is provided with a feed plate (6). A water storage tank is opened in the feed plate (6). The upper end of the feed plate (6) is provided with a mounting shaft (7). The upper end of the mounting shaft (7) passes through the mounting cover (2) and extends to the outside. A drive shaft (8) is located at the bottom of the feed plate (6). The bottom of the drive shaft (8) passes through the filter cylinder (5). A filter plate (9) is provided at the bottom of the filter box (1). A discharge pipe (10) is provided on one side of the bottom of the filter box (1).

2. A vaccine adjuvant filtration device according to claim 1, characterised in that: The feed plate (6) is provided with a filter layer (11). The bottom end of the feed plate (6) is provided with multiple discharge ports (12). Mounting plates (13) are provided on both sides of the multiple discharge ports (12). The same nozzle (14) is rotatably connected between two mounting plates (13) on the same side. Telescopic tubes (15) are provided between the discharge ports (12) and the nozzles (14) on the same side.

3. A vaccine adjuvant filtration device according to claim 1, wherein: The mounting shaft (7) passes through the feed trough which is connected to the water storage tank, and the upper end of the feed trough is rotatably connected to a matching feed pipe (16).

4. A vaccine adjuvant filtration device according to claim 1, wherein: The mounting cover (2) is provided with a drive motor (17) on one side of its upper end. The output end of the drive motor (17) is provided with a drive wheel (18). The outer side of the mounting shaft (7) is provided with an external toothed ring (19) that meshes with the drive wheel (18).

5. The vaccine adjuvant filtration device of claim 1, wherein: The upper end of the feed plate (6) is provided with a snap ring (20) with a "T" shaped cross section. The bottom end of the mounting cover (2) is provided with a snap groove that matches the snap ring (20). The snap ring (20) is located in the snap groove and is slidably connected to the side wall of the snap groove.

6. A vaccine adjuvant filtration device according to claim 1, wherein: The inner wall of the mounting sleeve (4) is provided with multiple guide plates (21), and the multiple guide plates (21) are all arranged in a spiral shape.

7. A vaccine adjuvant filtration device according to claim 1, wherein: Multiple stirring blades (22) are provided on the outside of the drive shaft (8) located inside the filter cylinder (5), and the multiple stirring blades (22) are arranged in a ring around the central axis of the drive shaft (8).

8. A vaccine adjuvant filtration device according to claim 1, wherein: Multiple matching first cleaning brushes (23) are provided on the outside of the drive shaft (8) located inside the filter cylinder (5). One side of each of the multiple first cleaning brushes (23) abuts against the inner wall of the filter cylinder (5). A second cleaning brush (24) is provided at the bottom of the drive shaft (8). The bottom of the second cleaning brush (24) abuts against the upper end of the filter plate (9).

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