Capsule shell dissolution testing device

Abstract

This invention provides a capsule shell solubility testing device, belonging to the field of pharmaceutical production and processing testing technology. The device features a simple, flexible, and adjustable structure, easy operation, and good testing results. The testing tank is shaped like an inverted frustum, with an open, large-diameter end facing upwards. Multiple lifting baskets are suspended within the tank's interior. Each basket is secured with a lifting cable via fixed lugs. Multiple winding machines are located outside the tank, with the lifting cables wound around them. The winding machines control the raising and lowering of the baskets. A central column stands vertically along its axis within the tank's interior, with a rotating arm mounted on top. A camera is fixedly suspended on the lower surface of the rotating arm's cantilevered end. This device offers flexible structure, independent testing tanks, smooth basket lifting, reduced interference, and high physiological environment fidelity, resulting in high testing accuracy.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical production, processing and testing technology, and in particular relates to a device for detecting the solubility of capsule shells. Background Technology

[0002] In the process of drug development, each step needs to be rigorously tested to ensure the quality and safety of the drug.

[0003] When developing capsule formulations for different indications, such as Zhenqi Jiangtang Capsules, Shenling Tongluo Capsules, and Yandan Yixin Capsules, different types of ingredients require different absorption sites. For example, some drugs need to be digested and absorbed in the stomach, while others need to be digested and absorbed in the intestines. Digestion and absorption in the wrong location can easily cause adverse effects. Therefore, it is necessary to select capsule shells with different solubility for coating. In other words, during the drug production and research and development process, it is necessary to accurately grasp the solubility of the capsule shell and the solvent in which it is dissolved.

[0004] Current equipment for testing the solubility of capsule shells mostly involves immersing a large number of capsule shells in a single container for testing. Increased solute concentration in the solvent will affect solubility and thus interfere with the accuracy of the test results. This makes it difficult to meet the actual needs of drug research and development testing, thereby affecting drug development. Therefore, there is an urgent need for a testing device that can be based on the actual needs of drug research and development. Utility Model Content

[0005] To address the problems existing in the background art, this utility model provides a capsule shell solubility detection device. The device has a simple, flexible, and adjustable structure, is easy to operate, and has good detection results.

[0006] The technical solution adopted by this utility model to solve its technical problem is: a capsule shell solubility detection device, including a detection tank, a rotating arm, a camera, multiple lifting baskets and multiple winding machines. The detection tank is in the shape of an inverted frustum, with the large-diameter end of the detection tank facing upwards open. Multiple lifting baskets are lifted and suspended in the inner cavity of the detection tank. Each lifting basket is equipped with a lifting cable by a fixed lifting lug. Multiple winding machines are set outside the detection tank. The winding end of the lifting cable is wound and mounted on the winding machine. The winding machine operates to perform the winding and unwinding of the lifting cable, that is, to realize the control of lifting and lowering the lifting basket. A central column is vertically erected along the axis in the inner cavity of the detection tank. The rotating arm is lifted and installed on the top of the central column. The camera is fixedly suspended on the lower surface of the cantilever end of the rotating arm.

[0007] Multiple guide bars are evenly distributed and fixed on the inner wall of the testing tank around the axis. Each guide bar is set along the generatrix of the testing tank, and each lifting basket is slidably mounted on any one of the guide bars.

[0008] The capsule shell solubility testing device also includes multiple partitions at the same height as the inner cavity of the testing tank. Each partition is a right-angled trapezoid with its bottom end facing upwards. A protruding insert is fixed to the top of the upright side of each partition. Multiple slots are evenly distributed around the axis along the top edge of the central column. The shape and size of each slot are matched with the insert. A vertically penetrating slot is opened on the inclined side of each partition. A positioning strip is protruding on the inner wall of the testing tank at the position corresponding to each positioning slot. The partitions are hung on the central column, and the positioning slots are snapped onto the positioning strips. Multiple partitions are movably hung on the central column, and adjacent partitions are sandwiched to form a testing slot. The lifting basket is located in the testing slot.

[0009] A slot is formed along the axis at the center of the top surface of the central column. A telescopic rod is fixedly installed in the slot. A drive motor is fixedly installed at the telescopic end of the telescopic rod pointing upwards. The mounting end of the rotating arm is fixedly connected to the driving end of the drive motor.

[0010] Each of the lifting baskets is a mesh box and is configured as a fan shape. The side wall of the large diameter end of the lifting basket matches the inner wall of the detection tank and is configured as an inclined arc surface. A guide groove is provided on the side wall of the large diameter end of the lifting basket in conjunction with a guide strip. The guide groove is set along the generatrix at the midpoint of the arc edge.

[0011] A support plate is fixedly extended on the lower outer wall of the testing tank, and multiple winding machines are fixedly placed on the support plate, with each winding machine aligned with each guide bar.

[0012] Each of the lifting baskets is equipped with two lifting lugs, which are symmetrically arranged about the guide groove. Lifting ropes are fixedly attached to each of the two lifting lugs. A wire-laying groove is opened at the upper edge of the testing tank and at the position corresponding to each lifting lug. The lifting ropes are placed in the wire-laying groove. Each winding machine is equipped with two lifting ropes, which are respectively attached to the two lifting lugs of each lifting basket. Each lifting rope is placed in the wire-laying groove.

[0013] Electric heating wires are fixedly clamped in the bottom plate and side wall of the testing tank, and the electric heating wires are electrically connected to the control component.

[0014] The beneficial effects of this invention are as follows: The device is equipped with multiple independent detection slots, ensuring that the reagents are isolated and do not flow together, preventing interference between solute concentrations and resulting in accurate detection results. Guide bars are installed in the detection tank, and guide grooves are provided on the lifting basket. The lifting cable frame is placed in the cable tray, ensuring smooth lifting and lowering of the basket, reducing reagent disturbance, avoiding impact on the capsule shell, eliminating additional interference, and improving image acquisition accuracy. An electric heating wire is installed in the detection tank to highly simulate the physiological environment, improving detection accuracy. The number of detection slots in the detection tank can be flexibly varied to meet different detection needs, offering strong adaptability and facilitating cost control. The camera is fixedly suspended on the lower surface of the rotating arm, which can rotate to accurately acquire images from different lifting baskets, avoiding the limitation of a single camera not being able to clearly capture a full image with focus, thus enhancing practicality. The winding machine is centrally located on the support plate on the outer wall of the detection tank, improving space utilization and making the overall structure of the device more compact. Attached Figure Description

[0015] In the attached diagram:

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model (the lifting cable is omitted in the diagram);

[0017] Figure 2 This is a schematic diagram of the lifting effect of the lifting basket of this utility model (the lifting cable is hidden in the figure);

[0018] Figure 3 This is a schematic diagram of the lifting basket structure of this utility model;

[0019] Figure 4 This is a schematic diagram of the partition plate structure of this utility model;

[0020] Figure 5 yes Figure 2 Enlarged view of part A in the middle;

[0021] Figure 6 This is a schematic diagram of the working structure of this utility model;

[0022] In the diagram: 1. Testing tank; 2. Lifting basket; 3. Rotating arm; 4. Camera; 5. Spacing plate; 6. Winding machine; 11. Center column; 12. Guide bar; 13. Cable tray; 14. Slot; 15. Telescopic rod; 16. Positioning bar; 17. Placing plate; 21. Guide groove; 22. Lifting lug; 51. Insert block; 52. Positioning groove. Detailed Implementation

[0023] The present invention will now be described in further detail with reference to the accompanying drawings. The drawings are simplified schematic diagrams, illustrating only the basic structure of the present invention, and therefore only show the components relevant to the present invention.

[0024] A capsule shell solubility testing device includes a testing tank 1, a rotating arm 3, a camera 4, multiple lifting baskets 2, and multiple winding machines 6. The testing tank 1 is shaped like an inverted frustum, with its large-diameter end open at the top. The multiple lifting baskets 2 are lifted and suspended inside the testing tank 1. Each lifting basket 2 is secured with a lifting cable via a fixed lifting lug 22. Multiple winding machines 6 are installed outside the testing tank 1, with the winding ends of the lifting cables wound around the winding machines 6. The winding machines 6 operate to perform the lifting operation. The winding and unwinding of the cable controls the lifting and lowering of the lifting basket 2. A central column 11 is vertically erected along the axis in the inner cavity of the detection tank 1. The rotating arm 3 is lifted and installed at the top of the central column 11. The camera 4 is fixedly suspended on the lower surface of the cantilever end of the rotating arm 3. The detection tank 1 is filled with dissolving agent. The capsule shell to be tested is placed in the lifting basket 2. The lifting basket 2 is lowered into the agent to dissolve the capsule shell. The lifting basket 2 is lifted, and the camera 4 captures the dissolution of the capsule shell in the lifting basket 2.

[0025] Multiple guide bars 12 are evenly distributed and fixed on the inner wall of the testing tank 1 around the axis. Each guide bar 12 is set along the generatrix of the testing tank 1. Each lifting basket 2 is slidably mounted on any guide bar 12. When the winding machine 6 winds and releases the lifting cable, the lifting basket 2 is displaced along the guide bar 12.

[0026] The capsule shell solubility detection device also includes multiple partition plates 5 set at the same height as the inner cavity of the detection tank 1. Each partition plate 5 is set as a right trapezoid with the bottom end facing upward. Each partition plate 5 has a fixed protruding insert 51 at the top of its upright side. Multiple slots 14 are evenly distributed around the axis at the top edge of the central column 11. The shape and size of each slot 14 are matched with the insert 51.

[0027] Each of the partition plates 5 has a through slot 52 on its inclined side. A slot strip 16 is provided on the inner wall of the detection tank 1 at the position corresponding to each slot 52. The partition plate 5 is hung on the central column 11, and the slot 52 is snapped onto the slot strip 16.

[0028] The upright side of the partition plate 5 matches the outer wall of the central column 11 and is set in an arc shape. The inclined side of the partition plate 5 matches the inner wall of the detection tank 1 and is set in an arc shape. Multiple partition plates 5 are movably hung on the central column 11 through mutually cooperating inserts 51 and slots 14. Adjacent partition plates 5 are sandwiched to form a detection groove. The lifting basket 2 is located in the detection groove. The dissolving agent in each detection groove does not flow.

[0029] A slot is formed along the axis at the center of the top surface of the central column 11. A telescopic rod 15 is fixedly installed in the slot. A drive motor is fixedly installed at the telescopic end of the telescopic rod 15 pointing upwards. The mounting end of the rotating arm 3 is fixedly connected to the driving end of the drive motor. When the telescopic rod 15 extends, the drive motor pushes the rotating arm 3 upwards. When the drive motor runs, it drives the rotating arm 3 to rotate around the axis of the central column 11. The rotating arm 3 rotates at a low speed. During the rotation of the rotating arm 3, the camera 4 performs image acquisition.

[0030] Each of the lifting baskets 2 is a mesh box and is configured as a fan shape. The side wall of the large diameter end of the lifting basket 2 is matched with the inner wall of the detection tank 1 and is configured as an inclined arc surface. A guide groove 21 is provided on the side wall of the large diameter end of the lifting basket 2 in conjunction with the guide strip 12. The guide groove 21 is set along the generatrix at the midpoint of the arc edge. When the lifting basket 2 is lifted and lowered, the guide groove 21 is always attached to and engaged with the guide strip 12. That is, the lifting basket 2 relies on the guide groove 21 to perform lifting and sliding displacement along the guide strip 12.

[0031] A support plate 17 is fixedly extended on the lower outer wall of the testing tank 1. Multiple winding machines 6 are fixedly placed on the support plate 17, and each winding machine 6 is aligned with each guide bar 12.

[0032] Each of the lifting baskets 2 is provided with two lifting lugs 22, which are symmetrically arranged about the guide groove 21. Lifting ropes are fixedly attached to each of the two lifting lugs 22. A wire-laying groove 13 is opened at the upper edge of the detection tank 1 at the position corresponding to each lifting lug 22. The lifting ropes are placed in the wire-laying groove 13. Each winding machine 6 is wound with two lifting ropes, which are respectively attached to the two lifting lugs 22 of each lifting basket 2. Each lifting rope is erected in the wire-laying groove 13.

[0033] Electric heating wires are fixedly clamped in the bottom plate and side wall of the detection tank 1. The electric heating wires are electrically connected to the control component. By operating the control component, the electric heating wires can be driven to control the temperature heating of the dissolved reagent in the detection tank 1 to simulate the human physiological environment and improve the detection accuracy. The electric heating wires and the control component are purchased externally, and a control component with timing and temperature control functions is selected.

[0034] The capsule shells are placed into the lifting basket 2. The winding machine 6 is controlled to release the lifting cable and lower the lifting basket 2. When the lifting basket 2 is lowered to its end, it is located in the middle section of the inner cavity of the detection tank 1. The radial ends of the lifting basket 2 are supported by the central column 11 and the inner wall of the detection tank 1, respectively. The bottom plate of the lifting basket 2 is in a suspended state, that is, the capsule shells are suspended and immersed in the dissolving agent. Multiple winding machines 6 are independently controlled to wind up the lifting cable at timed intervals to lift the lifting basket 2, that is, to simulate the time after the capsule shells are taken. The rotating arm 3 is controlled to rotate and drive the camera 4 to move above the lifted lifting basket 2. The camera 4 collects images of the lifting basket 2 and obtains the test results. After all the lifting baskets 2 are lifted and the image collection is completed, the image collection results are summarized and compared to obtain the test results. Then, the subsequent scientific research process can be carried out based on the test results.

[0035] When the device is in use, the number of lifting baskets 2 can be used according to the segment division set by the detection time. That is, when the solubility test is divided into four time periods, four lifting baskets 2 can be used. At this time, the inner cavity of the detection tank 1 can be divided into four detection slots by the partition plate 5, and one lifting basket 2 can be placed in each detection slot.

[0036] When placing the lifting basket 2 into the detection tank 1, the telescopic rod 15 needs to be controlled in advance to extend and lift the rotating arm 3 upwards, so as to avoid collisions during the placement of the lifting basket 2. After the required number of lifting baskets 2 have been placed, the telescopic rod 15 is adjusted to retract downwards to lower the rotating arm 3. Keeping the rotating arm 3 in a lowered state can ensure the clarity of the image results captured by the camera 4.

[0037] The above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A device for detecting the solubility of capsule shells, characterized in that: The system includes a testing tank (1), a rotating arm (3), a camera (4), multiple lifting baskets (2), and multiple winding machines (6). The testing tank (1) is in the shape of an inverted frustum. The large-diameter end of the testing tank (1) is open. Multiple lifting baskets (2) are lifted and suspended in the inner cavity of the testing tank (1). Each lifting basket (2) is equipped with a lifting cable by a fixed lifting lug (22). Multiple winding machines (6) are set outside the testing tank (1). The winding end of the lifting cable is wound around the winding machine (6). The winding machine (6) operates to perform the winding and unwinding of the lifting cable, thereby realizing the control of lifting and lowering the lifting basket (2). A central column (11) is vertically erected along the axis in the inner cavity of the testing tank (1). The rotating arm (3) is lifted and installed at the top of the central column (11). The camera (4) is fixedly suspended on the lower surface of the cantilever end of the rotating arm (3).

2. The capsule shell solubility detection device according to claim 1, characterized in that: Multiple guide bars (12) are evenly and fixedly arranged around the axis on the inner wall of the testing tank (1). Each guide bar (12) is arranged along the generatrix of the testing tank (1), and each lifting basket (2) is mounted on any guide bar (12) in a sliding frame.

3. The capsule shell solubility detection device according to claim 2, characterized in that: The capsule shell solubility detection device also includes multiple partition plates (5) set at the same height as the inner cavity of the detection tank (1). Each partition plate (5) is set as a right trapezoid with the bottom end facing upward. Each partition plate (5) has a fixed protruding insert (51) at the top of its upright side. Multiple slots (14) are evenly distributed around the axis at the top edge of the central column (11). The shape and size of each slot (14) are matched with the insert (51). Each partition plate (5) has a vertically penetrating slot (52) on its inclined side. A slot strip (16) is protruding on the inner wall of the detection tank (1) at the position corresponding to each slot (52). The partition plate (5) is hung on the central column (11). The slot (52) is snapped onto the slot strip (16). Multiple partition plates (5) are movably hung on the central column (11). The adjacent partition plates (5) are sandwiched together to form a detection groove. The lifting basket (2) is located in the detection groove.

4. The capsule shell solubility detection device according to claim 3, characterized in that: The center column (11) has a slot along the axis at the top center, and a telescopic rod (15) is fixedly installed in the slot. The telescopic end of the telescopic rod (15) pointing upwards is fixedly installed with a drive motor. The mounting end of the rotating arm (3) is fixedly connected to the driving end of the drive motor.

5. The capsule shell solubility detection device according to claim 4, characterized in that: Each of the lifting baskets (2) is a mesh box and is configured as a fan shape. The side wall of the large diameter end of the lifting basket (2) matches the inner wall of the detection tank (1) and is configured as an inclined arc surface. The side wall of the large diameter end of the lifting basket (2) is equipped with a guide groove (21) in conjunction with the guide strip (12). The guide groove (21) is set along the generatrix at the midpoint of the arc edge.

6. The capsule shell solubility detection device according to claim 5, characterized in that: The testing tank (1) has a fixed support plate (17) protruding from its lower outer wall. Multiple winding machines (6) are fixedly placed on the support plate (17), and each winding machine (6) is aligned with each guide bar (12).

7. The capsule shell solubility detection device according to claim 6, characterized in that: Each of the lifting baskets (2) is provided with two lifting lugs (22), which are symmetrically arranged about the guide groove (21). Lifting ropes are fixedly attached to each of the two lifting lugs (22). A wire-laying groove (13) is opened at the upper edge of the test tank (1) and at the position corresponding to each lifting lug (22). The lifting ropes are placed in the wire-laying groove (13). Each winding machine (6) is equipped with two lifting ropes, which are respectively attached to the two lifting lugs (22) of each lifting basket (2). Each lifting rope is erected in the wire-laying groove (13).

8. The capsule shell solubility detection device according to claim 7, characterized in that: Electric heating wires are fixedly clamped in the bottom plate and side wall of the detection tank (1), and the electric heating wires are electrically connected to the control component.

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