Microfluidic reagent card provided with a membrane support structure

Abstract

This invention provides a microfluidic reagent card with a membrane support structure, relating to the field of medical testing. It includes: a reagent card body, a reagent card upper membrane mounted on the surface of the reagent card body, an injection port on the surface of the reagent card upper membrane, a sample compartment body at one end of the top of the reagent card body, and a support structure body mounted on the bottom of the inner wall of the sample compartment body. In this invention, the support structure body mounted on the inner wall of the sample compartment body at one end of the top of the reagent card body supports the reagent card upper membrane located above the sample compartment body, preventing it from sinking into the sample compartment body. Excess sample enters the waste liquid tank through a passage three between the quantitative tank and the waste liquid tank, and residual plasma enters the residual plasma tank through a passage four between the flow tank and the residue tank, thereby treating excess sample and residual plasma.

Description

Technical Field

[0001] This utility model relates to the field of medical testing technology, and in particular to a microfluidic reagent card with a membrane support structure. Background Technology

[0002] Microfluidic reagent cards, as an important application of microfluidic technology, integrate complex analytical processes onto a small card, enabling functions such as sample introduction, reaction, separation, and detection. In the field of point-of-care testing, microfluidic reagent cards can provide strong support for rapid on-site diagnosis. For example, in disease diagnosis, they can quickly detect biomarkers in blood samples, helping doctors make timely diagnoses. However, current technologies lack supporting structures in reagent cards, posing a risk of membrane collapse in the sample compartment, which affects the usability of the reagent cards. Utility Model Content

[0003] The purpose of this invention is to provide a microfluidic reagent card with a membrane support structure to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: a microfluidic reagent card with a membrane support structure, comprising: a reagent card body, a reagent card upper membrane installed on the surface of the reagent card body, an injection port opened on the surface of the reagent card upper membrane, a sample compartment body opened at one end of the top of the reagent card body, and a support structure body installed at the bottom of the inner wall of the sample compartment body.

[0005] In a preferred embodiment, a quantitative groove is provided on the top of the reagent card body, and a through groove is provided between the quantitative groove and the sample compartment body.

[0006] In a preferred embodiment, a blood cell collection groove is provided on the top of the reagent card body, and a through groove is provided between the blood cell collection groove and the quantitative groove.

[0007] In a preferred embodiment, a flow groove is provided at the other end of the top of the reagent card body, a microchannel is provided between the flow groove and the quantitative groove, a detection hole one is provided at one end of the flow groove, and a detection hole two is provided at the other end of the flow groove.

[0008] In a preferred embodiment, a waste liquid tank is provided on the surface of the reagent card body, and a through groove is provided between the waste liquid tank and the quantitative tank.

[0009] In a preferred embodiment, the inner wall of the waste liquid tank is provided with an air vent.

[0010] In a preferred embodiment, a residue groove is provided at the other end of the reagent card body, and a through groove is provided between the residue groove and the flow groove.

[0011] In a preferred embodiment, the inner wall of the flow channel is provided with two air outlets.

[0012] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0013] 1. This utility model covers the top of the reagent card body with a membrane on the reagent card. The supporting structure installed at the bottom of the inner wall of the sample chamber body supports the membrane on the top of the reagent card body, preventing the membrane on the top of the sample chamber body from sinking into the interior of the sample chamber body, thus preventing any impact on the device and making the device more perfect.

[0014] 2. In this utility model, excess sample is allowed to enter the interior of the waste liquid tank through the three-channel opening between the quantitative tank and the waste liquid tank, and residual plasma is allowed to enter the interior of the residual tank through the four-channel opening between the flow tank and the residual tank, thereby treating excess sample and residual plasma and making the device more perfect. Attached Figure Description

[0015] Figure 1 A side view of a microfluidic reagent card with a membrane support structure provided by this utility model;

[0016] Figure 2 A side view of the membrane on a microfluidic reagent card with a membrane support structure provided by this utility model;

[0017] Figure 3 This is a partially enlarged view of a microfluidic reagent card with a membrane support structure provided by this utility model.

[0018] Legend:

[0019] 1. Reagent card body; 2. Reagent card upper membrane; 201. Injection port; 3. Sample compartment body; 4. Support structure body; 5. Through-channel one; 6. Quantitative channel; 7. Through-channel two; 8. Blood cell collection channel; 9. Microfluidic channel; 10. Flow channel; 11. Detection well one; 12. Detection well two; 13. Through-channel three; 14. Waste liquid tank; 15. Vent one; 16. Through-channel four; 17. Vent two; 18. Residue tank. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Please see Figure 1-3 This utility model provides a technical solution: a microfluidic reagent card with a membrane support structure, comprising: a reagent card body 1, a reagent card upper membrane 2 installed on the surface of the reagent card body 1, an injection port 201 opened on the surface of the reagent card upper membrane 2, a sample chamber body 3 opened at one end of the top of the reagent card body 1, and a support structure body 4 installed at the bottom of the inner wall of the sample chamber body 3.

[0022] Specifically: When the device is first used, the reagent card membrane 2 is placed on top of the reagent card body 1, and a blood sample is injected into the sample chamber body 3 at one end of the top of the reagent card body 1 through the injection port 201 on the surface of the reagent card membrane 2. The support structure body 4 installed at the bottom of the inner wall of the sample chamber body 3 supports the reagent card membrane 2 covering the top of the reagent card body 1, preventing the reagent card membrane 2 located on top of the sample chamber body 3 from sinking into the sample chamber body 3, thus preventing any impact on the device and making the device more perfect.

[0023] In one embodiment, a quantitative groove 6 is provided on the top of the reagent card body 1, a through groove 5 is provided between the quantitative groove 6 and the sample compartment body 3, a blood cell collection groove 8 is provided on the top of the reagent card body 1, a through groove 7 is provided between the blood cell collection groove 8 and the quantitative groove 6, a flow groove 10 is provided at the other end of the top of the reagent card body 1, a microchannel 9 is provided between the flow groove 10 and the quantitative groove 6, a detection hole 11 is provided at one end of the flow groove 10, and a detection hole 12 is provided at the other end of the flow groove 10.

[0024] Specifically: After the blood sample enters the sample chamber body 3, it enters the quantitative tank 6 through the through channel 5 between the sample chamber body 3 and the quantitative tank 6. Then, the device is placed on a centrifuge, and the blood cells and plasma in the quantitative tank 6 are separated under centrifugal force. The blood cells enter the blood cell collection tank 8 through the through channel 7 between the quantitative tank 6 and the blood cell collection tank 8. Then, the centrifugation is stopped, and the plasma enters the flow tank 10 through the microchannel 9 between the flow tank 10 and the quantitative tank 6. After entering the flow tank 10, the plasma flows into the detection port 11 and detection port 12 installed at one end of the flow tank 10 for subsequent detection, making the device more complete.

[0025] In one embodiment, a waste liquid tank 14 is provided on the surface of the reagent card body 1, a through groove 13 is provided between the waste liquid tank 14 and the quantitative tank 6, and an air vent 15 is provided on the inner wall of the waste liquid tank 14.

[0026] Specifically: After the blood enters the quantitative tank 6, in order to ensure sufficient sample, a larger amount of sample will be injected into the device. The excess sample will enter the waste liquid tank 14 through the through-slot 13 between the quantitative tank 6 and the waste liquid tank 14, so that the excess sample is processed. At the same time, the gas inside the device after the sample is injected can be discharged through the vent 15 on the inner wall of the waste liquid tank 14, preventing the gas inside the device from entering the sample and affecting the detection, thus making the device more perfect.

[0027] In one embodiment, a residual groove 18 is provided at the other end of the reagent card body 1, a through groove 16 is provided between the residual groove 18 and the flow groove 10, and an air outlet 17 is provided on the inner wall of the flow groove 10.

[0028] Specifically: After entering the flow cell 10, the plasma flows into the detection port 11 and the detection port 2 12. After flowing in, some plasma will remain. The plasma will flow into the residual tank 18 through the channel 4 16 between the flow cell 10 and the residual tank 18, so that the residual plasma is treated. At the same time, when the plasma flows into the flow cell 10 through the microchannel 9, the air inside the flow cell 10 will be discharged through the air outlet 2 17 on the inner wall of the flow cell 10 to prevent gas from entering the sample and affecting the detection, thus making the device more perfect.

[0029] Working Principle: When the device is first used, the reagent card membrane 2 is placed on top of the reagent card body 1. The support structure 4 installed at the bottom of the inner wall of the sample chamber body 3 supports the reagent card membrane 2 on top of the reagent card body 1, preventing it from sinking into the sample chamber body 3 and affecting the device. Blood samples are injected into the sample chamber body 3, which is located at the top of the reagent card body 1, through the injection port 201 on the surface of the reagent card membrane 2. The sample enters the quantitative tank 6 through the through-channel 5 between the sample chamber body 3 and the quantitative tank 6. The device is then placed on a centrifuge, and the blood sample in the quantitative tank 6 is centrifuged to separate blood cells and plasma. Blood cells enter the blood cell collection tank 8 through the through-channel 7 between the quantitative tank 6 and the blood cell collection tank 8. Centrifugation is then stopped, and the plasma enters the flow tank 10 through the microchannel 9 between the flow tank 10 and the quantitative tank 6. After entering the flow tank 10, the plasma... The blood will flow into the detection holes 11 and 12 installed at one end of the flow channel 10 for subsequent detection, making the device more complete. During use, after the blood enters the quantitative tank 6, more sample will be injected into the device to ensure sufficient sample. The excess sample will enter the waste liquid tank 14 through the passage 3 13 between the quantitative tank 6 and the waste liquid tank 14, so that the excess sample is processed. At the same time, the gas inside the device can be discharged through the vent 15 on the inner wall of the waste liquid tank 14 after the sample is injected. After the plasma enters the flow channel 10, it flows into the detection holes 11 and 12. After flowing in, some residue will remain. The residue will flow into the residue tank 18 through the passage 4 16 between the flow channel 10 and the residue tank 18, so that the residual plasma is processed. At the same time, when the plasma flows into the flow channel 10 through the microchannel 9, the air inside the flow channel 10 will be discharged through the vent 2 17 on the inner wall of the flow channel 10 to prevent gas from entering the sample and affecting the detection, making the device more complete.

[0030] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.

Claims

1. A microfluidic reagent card with a membrane support structure, characterized in that, include: The reagent card body (1) has a reagent card upper membrane (2) installed on its surface. An injection port (201) is opened on the surface of the reagent card upper membrane (2). A sample chamber body (3) is opened at one end of the top of the reagent card body (1). A support structure body (4) is installed at the bottom of the inner wall of the sample chamber body (3).

2. A microfluidic reagent card with a membrane support structure according to claim 1, characterized in that: The reagent card body (1) has a quantitative groove (6) on its top, and a through groove (5) is provided between the quantitative groove (6) and the sample compartment body (3).

3. A microfluidic reagent card with a membrane support structure according to claim 1, characterized in that: The top of the reagent card body (1) is provided with a blood cell collection groove (8), and a through groove (7) is provided between the blood cell collection groove (8) and the quantitative groove (6).

4. A microfluidic reagent card with a membrane support structure according to claim 1, characterized in that: The reagent card body (1) has a flow groove (10) at one end of its top. A microchannel (9) is provided between the flow groove (10) and the quantitative groove (6). A detection hole one (11) is provided at one end of the flow groove (10), and a detection hole two (12) is provided at one end of the flow groove (10).

5. A microfluidic reagent card with a membrane support structure according to claim 1, characterized in that: The surface of the reagent card body (1) is provided with a waste liquid tank (14), and a through groove (13) is provided between the waste liquid tank (14) and the quantitative tank (6).

6. A microfluidic reagent card with a membrane support structure according to claim 5, characterized in that: The waste liquid tank (14) has an air vent (15) on its inner wall.

7. A microfluidic reagent card with a membrane support structure according to claim 1, characterized in that: The other end of the reagent card body (1) is provided with a residual groove (18), and a through groove (16) is provided between the residual groove (18) and the flow groove (10).

8. A microfluidic reagent card with a membrane support structure according to claim 4, characterized in that: The inner wall of the flow channel (10) is provided with two air outlets (17).

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