Modular chromatography column kit with quick change packing

Abstract

The application discloses a modular chromatographic column kit with quickly replaceable filler, relates to the field of chromatographic columns, and comprises a base and a chromatographic column body, wherein the base is provided with a discharging assembly for conveniently discharging materials. The application is provided through the cooperation of the structures such as the supporting rod, the first spring and the limiting sleeve, and in use, the two sliding plates are made to approach each other through the first spring to make the limiting sleeve be sleeved at the two ends of the chromatographic column body, the chromatographic column body is limited and fixed, the chromatographic column body is prevented from shaking, then the filler is added into the chromatographic column body, when discharging materials is needed, the sliding plates are made to slide in the sliding grooves to compress the first spring, the limiting sleeve is made to be away from the chromatographic column body, then the chromatographic column body is swung to be inverted, the filler is made to be quickly discharged, and the problem that the discharge is relatively slow through the liquid outlet pipe when discharging materials, thereby reducing the work efficiency, is avoided as much as possible.

Description

Technical Field

[0001] This application relates to the field of chromatography columns, and more particularly to modular chromatography column kits with quick-change packing materials. Background Technology

[0002] A chromatography column is an instrument used in the chromatographic separation of mixtures. It mainly consists of a column body, a liquid outlet tube at the bottom of the column, and a liquid outlet valve on the outlet tube. When using a chromatography column, a stationary phase must first be packed into the column. One common method is called the dry packing method. The specific procedure is as follows: Fill the column with approximately two-thirds solvent, open the outlet valve to allow the solvent to flow out slowly (usually a conical flask is placed below the outlet tube to collect the solvent), then pour the dry adsorbent used as the stationary phase into the column, allowing it to settle evenly to the bottom. After packing, use a dropper to draw a small amount of solution to flush the adsorbent particles adhering to the inner wall of the column into the column. Next, pack a thin layer of clean fine sand into the column and gently press it down with a glass rod. Finally, add solvent repeatedly, allowing it to pass through the stationary phase within the column while gently pressing it down with the glass rod, until a relatively dense stationary phase is obtained within the column.

[0003] Utility model patent CN210251324U discloses a modular chromatography column, comprising a column body, an outlet pipe, an outlet valve, a base column, a lifting rod, a horizontal rod, and a rinsing block. The column body is mounted on the base column, with an outlet pipe at the bottom of the column body and an outlet valve on the outlet pipe. The base column is hollow, with the lifting rod inserted into the base column. The horizontal rod is horizontally mounted on the top of the lifting rod, and a rinsing block is installed at the end of the horizontal rod, aligned with the column body. The rinsing block is cylindrical, with a diameter smaller than the inner diameter of the column body. A rinsing channel is provided inside the rinsing block, with the inlet of the rinsing channel located on the upper surface of the rinsing block, and multiple outlets evenly distributed on the sides of the rinsing block.

[0004] One of the modular chromatography columns mentioned above involves adding solvent, dry adsorbent, and clean fine sand to the column to obtain a relatively dense stationary phase. Since most packing materials are disposable, they need to be frequently loaded and replaced. The stationary phase is compacted inside the column, and the discharge through the outlet pipe is relatively slow, which reduces work efficiency. Utility Model Content

[0005] To address the aforementioned issues, this application provides a modular chromatography column kit with rapidly replaceable packing material.

[0006] The modular chromatography column kit with quick-change packing material provided in this application adopts the following technical solution:

[0007] A modular chromatography column kit with quick-change packing material includes a base and a chromatography column body. The base is equipped with a discharge assembly for easy material unloading. The discharge assembly includes a support column fixedly connected to the upper surface of the base. A support rod is fixedly connected to one side wall of the support column. One end of the support rod is rotatably connected to one side wall of the chromatography column body. A groove is formed on one side wall of the support column above and below the support rod. A sliding plate is slidably disposed in each groove. A first spring is fixedly connected to the opposite side wall of each of the two sliding plates. The other end of the first spring is fixedly connected to the side wall of the groove. A limiting sleeve is fixedly connected to the end of the sliding plate away from the groove. The limiting sleeves are respectively fitted on both ends of the chromatography column body.

[0008] By adopting the above technical solution, during use, the first spring pushes the sliding plate, bringing the two sliding plates closer together. The limiting sleeve is then fitted onto both ends of the chromatography column body to limit and fix the chromatography column body, preventing it from shaking. Then, the packing material is added into the chromatography column body. When unloading is required, the sliding plate is slid within the groove, compressing the first spring and moving the limiting sleeve away from the chromatography column body. Then, the chromatography column body is inverted by swinging, allowing the packing material to be discharged quickly. This minimizes the problem of slow discharge through the outlet pipe during unloading, which reduces work efficiency.

[0009] Preferably, a collection box is provided on the upper surface of the base on one side of the support column, and a rubber hose is fixedly connected to the top of the collection box, and the top of the chromatography column body is inserted into the rubber hose.

[0010] By adopting the above technical solution, when the chromatography column is inverted, the top of the chromatography column is inserted into the rubber hose, which facilitates the collection of packing material and prevents the packing material from falling from a height and scattering everywhere when tilted.

[0011] Preferably, a connecting plate is fixedly connected to the top of the side wall of the support column near the rubber hose, and a connecting groove is formed on the upper surface of the connecting plate. An L-shaped clamping plate is fixedly connected to the top side wall of the rubber hose, and the end of the L-shaped clamping plate away from the rubber hose is clamped into the connecting groove.

[0012] By adopting the above technical solution, after pouring the packing material from the chromatography column into the rubber hose, inserting the L-shaped clamp into the connecting groove can make the rubber hose stand up, facilitating the packing material to enter the collection box, while preventing the rubber hose from being placed randomly.

[0013] Preferably, the upper surface of the base has multiple mounting holes for fixing.

[0014] By adopting the above technical solution, the base can be easily fixed through the mounting holes, preventing the support column from shaking and causing it to tip over.

[0015] Preferably, each of the slide grooves is fixedly connected to a fixed rod, and the slide plate and the first spring are both sleeved on the fixed rod.

[0016] By adopting the above technical solution, the stability of the first spring and the slide can be improved by using a fixing rod, preventing the first spring from bending when the slide compresses it.

[0017] Preferably, two annular arrayed arc plates are hinged to the top of the side wall of the chromatography column body. A second spring is fixedly connected to the bottom of the side wall of the arc plate near the chromatography column body. The end of the second spring away from the arc plate is fixedly connected to the chromatography column body.

[0018] By adopting the above technical solution, when inserting the chromatography column body into the rubber hose, first press the bottom end of the arc plate to squeeze the second spring, so that the top of the arc plate is away from the chromatography column body. Then, insert the chromatography column body into the rubber hose. By releasing the arc plate, the second spring rebounds and the top of the arc plate approaches the chromatography column body, so that the rubber hose abuts against the chromatography column body, thereby improving the stability of the connection between the rubber hose and the chromatography column body.

[0019] Preferably, anti-slip teeth are fixedly connected to the top of the side wall of the arc-shaped plate near the chromatography column body.

[0020] By adopting the above technical solution, the anti-slip toothed blocks can improve the contact stability of the arc plate with the rubber hose, preventing the rubber hose from sliding on the arc plate and causing the rubber hose to detach from the chromatography column body.

[0021] In summary, this application includes at least one of the following beneficial technical effects:

[0022] 1. This application utilizes the cooperative arrangement of support rods, a first spring, and limiting sleeves. During use, the first spring pushes the sliding plate, bringing the two sliding plates closer together. The limiting sleeves are then fitted onto both ends of the chromatography column body to limit and fix the chromatography column body, preventing it from shaking. The packing material is then added into the chromatography column body. When unloading is required, the sliding plate is slid within the groove, compressing the first spring and moving the limiting sleeves away from the chromatography column body. Then, the chromatography column body is inverted by swinging, allowing the packing material to be discharged quickly. This minimizes the problem of slow discharge through the outlet pipe during unloading, which reduces work efficiency.

[0023] 2. When inserting the chromatography column body into the rubber tubing, first press the bottom of the arc plate to compress the second spring, so that the top of the arc plate is away from the chromatography column body. Then insert the chromatography column body into the rubber tubing. By releasing the arc plate, the second spring rebounds and the top of the arc plate approaches the chromatography column body, so that the rubber tubing abuts against the chromatography column body, improving the stability of the connection between the rubber tubing and the chromatography column body. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the overall structure of the modular chromatography column kit with quick-change packing material according to an embodiment of this application;

[0025] Figure 2 The embodiments of this application mainly embody Figure 1 A schematic diagram of the enlarged structure of region A in the middle;

[0026] Figure 3 This is a schematic diagram illustrating the arc-shaped plate and the second spring structure, which are the main features of the embodiments of this application.

[0027] Figure 4 This is an exploded view of the connection structure of the L-shaped card plate and the connecting groove, which is the main embodiment of this application.

[0028] Reference numerals in the attached drawings: 1. Base; 2. Chromatography column body; 3. Support column; 4. Support rod; 5. Slide groove; 6. Slide plate; 7. First spring; 8. Limiting sleeve; 9. Collection box; 10. Rubber hose; 11. Connecting plate; 12. Connecting groove; 13. L-shaped clamping plate; 14. Mounting hole; 15. Fixing rod; 16. Arc plate; 17. Second spring; 18. Anti-slip tooth block. Detailed Implementation

[0029] The following is in conjunction with the appendix Figures 1-4 This application will be described in further detail.

[0030] This application discloses a modular chromatography column kit with rapidly replaceable packing material.

[0031] Reference Figure 1 , Figure 2 and Figure 3 A modular chromatography column kit with quick-change packing material includes a base 1 and a chromatography column body 2. The base 1 is equipped with a discharge assembly for easy material unloading. The discharge assembly includes a support column 3, a support rod 4, a chute 5, a slide plate 6, a first spring 7, and a limiting sleeve 8.

[0032] The support column 3 is fixedly connected to the upper surface of the base 1. The support rod 4 is fixedly connected to one side wall of the support column 3. One end of the support rod 4 is rotatably connected to one side wall of the chromatography column body 2. Two slide grooves 5 are provided, both of which are opened on one side wall of the support column 3 and are located above and below the support rod 4 respectively. Two slide plates 6 are provided and are slidably disposed in the slide grooves 5 respectively. Two first springs 7 are provided and are fixedly connected to the opposite side walls of the two slide plates 6 respectively. The other end of the first spring 7 is fixedly connected to the side wall of the slide groove 5. Two limiting sleeves 8 are provided and are fixedly connected to the end of the slide plate 6 away from the slide groove 5 respectively. The limiting sleeves 8 are respectively fitted on both ends of the chromatography column body 2.

[0033] Reference Figure 1 A collection box 9 is provided on one side of the support column 3 on the upper surface of the base 1. A rubber hose 10 is fixedly connected to the top of the collection box 9. The top of the chromatography column body 2 is inserted into the rubber hose 10. When the chromatography column body 2 is inverted, the top of the chromatography column body 2 is inserted into the rubber hose 10, which facilitates the collection of packing material and prevents the packing material from falling from a height and scattering everywhere when tilted.

[0034] Reference Figure 1 and Figure 4 A connecting plate 11 is fixedly connected to the top of the side wall of the support column 3 near the rubber hose 10. A connecting groove 12 is provided on the upper surface of the connecting plate 11. An L-shaped clamping plate 13 is fixedly connected to the side wall of the top of the rubber hose 10. The end of the L-shaped clamping plate 13 away from the rubber hose 10 is clamped into the connecting groove 12. After the packing material in the chromatography column body 2 is poured into the rubber hose 10, the L-shaped clamping plate 13 is clamped into the connecting groove 12, which can make the rubber hose 10 stand up, making it easier for the packing material to enter the collection box 9, and at the same time preventing the rubber hose 10 from being placed randomly.

[0035] Reference Figure 1 The upper surface of the base 1 has multiple mounting holes 14 for fixing. The mounting holes 14 facilitate fixing of the base 1 and prevent the support column 3 from shaking and causing it to tip over.

[0036] Reference Figure 1 and Figure 2 Each groove 5 is fixedly connected with a fixing rod 15. The slide plate 6 and the first spring 7 are both sleeved on the fixing rod 15. The fixing rod 15 can improve the stability of the first spring 7 and the slide plate 6 and prevent the first spring 7 from bending when the slide plate 6 squeezes the first spring 7.

[0037] Reference Figure 1 and Figure 3Two annular arrays of arc-shaped plates 16 are hinged to the top of the side wall of the chromatography column body 2. A second spring 17 is fixedly connected to the bottom of the side wall of the arc-shaped plate 16 near the chromatography column body 2. The end of the second spring 17 away from the arc-shaped plate 16 is fixedly connected to the chromatography column body 2. When the chromatography column body 2 is inserted into the rubber hose 10, the bottom of the arc-shaped plate 16 is pressed first to squeeze the second spring 17, so that the top of the arc-shaped plate 16 is away from the chromatography column body 2. Then the chromatography column body 2 is inserted into the rubber hose 10. By releasing the arc-shaped plate 16, the second spring 17 rebounds. When the top of the arc-shaped plate 16 is close to the chromatography column body 2, the rubber hose 10 is pressed against the chromatography column body 2, improving the stability of the connection between the rubber hose 10 and the chromatography column body 2.

[0038] Reference Figure 3 Anti-slip teeth 18 are fixedly connected to the top of the side wall of the arc plate 16 near the chromatography column body 2. The anti-slip teeth 18 can improve the contact stability of the arc plate 16 with the rubber hose 10 and prevent the rubber hose 10 from sliding on the arc plate 16, causing the rubber hose 10 to detach from the chromatography column body 2.

[0039] The implementation principle of the modular chromatography column kit with quick-change packing material in this application embodiment is as follows: During use, the first spring 7 pushes the sliding plate 6, bringing the two sliding plates 6 closer together. The limiting sleeve 8 is then fitted onto both ends of the chromatography column body 2 to limit and fix the column body 2, preventing it from shaking. Then, the packing material is added into the chromatography column body 2. When unloading is required, the sliding plate 6 slides within the groove 5, compressing the first spring 7 and moving the limiting sleeve 8 away from the chromatography column body 2. Then, the top of the chromatography column body 2 is inserted into the rubber hose 10. By swinging the chromatography column body 2, it is inverted, allowing the packing material to be added. The material is quickly discharged into the collection box 9 through the rubber hose 10. At the same time, when the chromatography column body 2 is inserted into the rubber hose 10, the bottom end of the arc plate 16 is pressed first to squeeze the second spring 17, so that the top of the arc plate 16 is away from the chromatography column body 2. Then the chromatography column body 2 is inserted into the rubber hose 10. By releasing the arc plate 16, the second spring 17 rebounds and the top of the arc plate 16 is brought close to the chromatography column body 2, so that the rubber hose 10 is pressed against the chromatography column body 2. This improves the stability of the connection between the rubber hose 10 and the chromatography column body 2 and avoids the problem of slow discharge through the liquid outlet pipe during unloading, which would reduce work efficiency.

[0040] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A modular chromatography column kit with quick-change packing, comprising a base (1) and a chromatography column body (2), a discharging assembly for facilitating discharging is arranged on the base (1), characterized in that: The unloading assembly includes a support column (3) fixedly connected to the upper surface of the base (1), one side wall of the support column (3) is fixedly connected with a support rod (4), one end of the support rod (4) is rotatably connected with one side wall of the chromatography column body (2), a sliding groove (5) is formed above and below the support rod (4) on one side wall of the support column (3), a sliding plate (6) is slidably arranged in the sliding groove (5), a first spring (7) is fixedly connected to the side wall of the sliding plate (6) away from the sliding groove (5), the other end of the first spring (7) is fixedly connected with the side wall of the sliding groove (5), a limiting sleeve (8) is fixedly connected to the end of the sliding plate (6) away from the sliding groove (5), and the limiting sleeve (8) is sleeved on both ends of the chromatography column body (2).

2. The modular, quick-change packed bed column kit of claim 1, wherein: The upper surface of the base (1) is provided with a collecting box (9) on one side of the support column (3), the top of the collecting box (9) is fixedly connected with a rubber hose (10), and the top of the chromatography column body (2) is inserted with the rubber hose (10).

3. The modular, quick-change packed bed column kit of claim 2, wherein: The support column (3) is fixedly connected with a connecting plate (11) on the top of the side wall close to the rubber hose (10).

4. The modular, quick-change packed bed column kit of claim 3, wherein: The rubber hose (10) is fixedly connected with an L-shaped clamping plate (13) on one side of the top, and the end of the L-shaped clamping plate (13) away from the rubber hose (10) is clamped in the connecting groove (12).

5. The modular, quick-change packed bed column kit of claim 4, wherein: The upper surface of the base (1) is provided with a plurality of mounting holes (14) for fixing.

6. The modular, quick change disposable chromatography column kit of claim 5, wherein: The sliding groove (5) is fixedly connected with a fixing rod (15), and the sliding plate (6) and the first spring (7) are sleeved on the fixing rod (15).

7. The modular, quick-change packed bed column kit of claim 6, wherein: The chromatography column body (2) is hingedly connected with two annular arrays of arc-shaped plates (16) on the top of the side wall, the arc-shaped plate (16) is fixedly connected with a second spring (17) on the side wall close to the chromatography column body (2), and the end of the second spring (17) away from the arc-shaped plate (16) is fixedly connected with the chromatography column body (2).

8. The modular, quick change disposable chromatography column kit of claim 7, wherein: The arc-shaped plate (16) is fixedly connected with an anti-skid tooth block (18) on the top of the side wall close to the chromatography column body (2).

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