A convenient and efficient continuous reaction device

Abstract

The utility model relates to the technical field of continuous production of pharmaceutical intermediates, and disclose a kind of convenient and efficient continuous reaction device, including tank body, tank body middle part left side outer wall is fixedly connected with feed pipe, tank body right side outer wall is fixedly connected with overflow pipe;Further comprising: stirring mechanism, stirring mechanism is installed in tank body interior, and stirring mechanism is used to sufficiently mix the material in tank body interior;Auxiliary stirring mechanism, auxiliary stirring stirring mechanism is installed in the left and right sides of stirring mechanism;Driving mechanism, driving mechanism is installed on the upper end of tank body.The utility model is driven by stirring shaft first stirring vane, second stirring vane, and the material is turned over in a wide range along the radial direction, while a pair of helical blades are driven by rotating rod and do reverse rotation and revolution, form a plurality of longitudinal circulating flow, significantly reduce the proportion of dead zone in tank, make residence time distribution narrow, reaction selectivity improves, product yield and quality stability synchronous promotion.

Description

Technical Field

[0001] This utility model relates to the field of continuous production technology of pharmaceutical intermediates, and in particular to a convenient and efficient continuous reaction device. Background Technology

[0002] Pharmaceutical intermediates are compounds that lie between the starting materials and the active pharmaceutical ingredient (API) in the drug synthesis pathway. These compounds typically do not have direct pharmaceutical value, but they are an indispensable part of drug synthesis, providing the necessary framework or functional groups for the construction of drug molecular structures.

[0003] In continuous reaction production, the continuous stirred tank reactor (CSTR) is widely favored due to its simple structure and high flexibility. The CSTR mainly injects fresh materials from the top and mixes them rapidly with the liquid in the reactor under mechanical stirring, so that the temperature and concentration can be quickly uniformized. When the reaction reaches the set conversion rate, the product is continuously discharged from the overflow port, the liquid level is kept constant, and the system enters steady-state operation.

[0004] However, traditional continuous stirred tanks generally suffer from the following defects in actual operation: the phenomenon of stirring dead zones leads to a wide distribution of material residence time and a decrease in reaction selectivity. Utility Model Content

[0005] In order to overcome the above-mentioned defects of the prior art, this utility model provides a convenient and efficient continuous reaction device to solve the problem that the dead zone phenomenon in the traditional continuous stirred tank leads to a wide distribution of material residence time and a decrease in reaction selectivity.

[0006] This utility model provides a convenient and efficient continuous reaction device, including a tank, with a feed pipe fixedly connected to the outer wall of the left side of the middle portion of the tank, and an overflow pipe fixedly connected to the outer wall of the right side of the tank; it also includes:

[0007] A stirring mechanism is installed inside the tank and is used to thoroughly mix the materials inside the tank.

[0008] An auxiliary stirring mechanism is installed on the left and right sides of the stirring mechanism;

[0009] A drive mechanism is installed at the upper end of the tank body, and the drive mechanism is used to provide power for the operation of both the stirring mechanism and the auxiliary stirring mechanism.

[0010] Preferably, the stirring mechanism includes a stirring shaft and first stirring blades. The stirring shaft is rotatably connected to the upper part of the tank. Multiple first stirring blades are provided and fixedly connected to the side wall of the stirring shaft at equal intervals.

[0011] Preferably, the stirring mechanism further includes a mounting block and a second stirring blade. The mounting block is fixedly connected to the lower side wall of the stirring shaft, and a connecting rod is fixedly connected to the lower end of the mounting block. The lower end of the connecting rod passes through the tank and is rotatably connected to it. Multiple second stirring blades are provided and are fixedly connected to the side wall of the connecting rod at equal intervals.

[0012] Preferably, the auxiliary stirring mechanism includes a transmission rod and a rotating rod. The transmission rod is located inside the stirring shaft and rotatably connected to it. A pair of rotating rods are provided and rotatably connected to the end of the mounting block. A spiral blade is fixedly connected to the side wall of the rotating rod located above the mounting block. The two rotating rods are respectively connected to the transmission rod through a pulley assembly, which is located inside the mounting block.

[0013] Preferably, the driving mechanism includes a motor and a first bevel gear. The motor is fixedly connected to the upper end of the tank via a mounting bracket. The first bevel gear is fixedly connected to the output shaft end of the motor. The upper and lower sidewalls of the first bevel gear are meshed with second bevel gears. The second bevel gear located above the first bevel gear is fixedly connected to the upper sidewall of the rotating rod, and the second bevel gear located below the first bevel gear is fixedly connected to the upper sidewall of the stirring shaft.

[0014] Preferably, the height between the feed inlet of the feed pipe and the top of the tank is greater than the height between the overflow pipe and the top of the tank, and a discharge pipe is fixedly connected to the bottom of the tank, with a valve fixedly connected to the side wall of the discharge pipe.

[0015] Compared with the prior art, the beneficial effects of this utility model are:

[0016] 1. This utility model uses a stirring shaft to drive the first stirring blade and the second stirring blade to tumble the material over a wide range in the radial direction. At the same time, a pair of spiral blades rotate in opposite directions and revolve around the center under the drive of the rotating rod, forming multiple longitudinal circulating flows. This significantly reduces the proportion of dead zones in the tank, narrows the residence time distribution, improves reaction selectivity, and simultaneously improves product yield and quality stability.

[0017] 2. This utility model uses a motor to coaxially drive a pair of second bevel gears to rotate, so that a single power source can synchronously output the rotation of the stirring shaft and the transmission rod, saving the space and energy consumption of multiple motors; the liquid level difference design of the feed pipe being higher than the overflow pipe, combined with the bottom openable and closable discharge pipe, can maintain a constant liquid level during continuous steady-state operation, and can quickly drain residual liquid during batch switching or maintenance, making operation convenient and maintenance efficient. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall main structure of this utility model;

[0019] Figure 2This is a schematic diagram of the main cross-sectional structure of the tank body of this utility model;

[0020] Figure 3 This utility model Figure 2 Enlarged structural diagram of section A;

[0021] Figure 4 This is a schematic diagram of the main cross-sectional structure of the stirring mechanism of this utility model;

[0022] Figure 5 This utility model Figure 4 Enlarged structural diagram of section B.

[0023] Numbering on the map:

[0024] 1. Tank body; 11. Feed pipe; 12. Overflow pipe; 13. Discharge pipe; 2. Stirring mechanism; 21. Stirring shaft; 22. First stirring blade; 23. Mounting block; 24. Connecting rod; 25. Second stirring blade; 3. Auxiliary stirring mechanism; 31. Transmission rod; 32. Rotating rod; 33. Spiral blade; 34. Pulley assembly; 4. Drive mechanism; 41. Motor; 42. First bevel gear; 43. Second bevel gear. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0026] like Figure 1-5 As shown, this utility model has the following three specific embodiments.

[0027] Example 1

[0028] A convenient and efficient continuous reaction device includes a tank 1, with a feed pipe 11 fixedly connected to the outer wall of the left side of the middle section of the tank 1, and an overflow pipe 12 fixedly connected to the outer wall of the right side of the tank 1; it also includes:

[0029] A stirring mechanism 2 is installed inside the tank 1 and is used to fully mix the materials inside the tank 1.

[0030] Auxiliary stirring mechanism 3 and auxiliary stirring mechanism 2 are installed on the left and right sides of stirring mechanism 2;

[0031] Drive mechanism 4 is installed on the upper end of tank 1. Drive mechanism 4 is used to provide power for the operation of stirring mechanism 2 and auxiliary stirring mechanism 3 at the same time.

[0032] The height between the feed inlet of the feed pipe 11 and the top of the tank 1 is greater than the height between the overflow pipe 12 and the top of the tank 1. The bottom of the tank 1 is fixedly connected to the discharge pipe 13, and a valve is fixedly connected to the side wall of the discharge pipe 13.

[0033] In this embodiment, as Figures 1-2 As shown, tank 1 is arranged vertically, with the top sealed by a flange. The feed pipe 11, welded to the outer wall on the left side of the middle section, extends obliquely upward, and its outlet is located at a depth of about one-third below the liquid surface. The overflow pipe 12 is welded to the outer wall on the right side, and the discharge pipe 13 is welded vertically downward to the center of the bottom of tank 1. The valve is in the normally closed state.

[0034] Before starting, an appropriate amount of initial solvent is injected into the tank 1 through the feed pipe 11 to make the liquid level lower than the inlet of the overflow pipe 12 to form a stable liquid level. Then, the drive mechanism 4 is turned on, which simultaneously drives the stirring mechanism 2 and the auxiliary stirring mechanism 3 to operate. Then, the fresh material enters from the feed pipe 11 and is quickly drawn into the mainstream area to be fully homogenized with the liquid in the tank. As the reaction proceeds, the product concentration gradually increases. When the product concentration reaches the specified concentration, the initial solvent is heated in the feed pipe 11 at the same time to avoid the concentration being too high. When the liquid level exceeds the height of the overflow pipe 12, the product is continuously collected along the overflow pipe 12.

[0035] When it is necessary to clean the inside of tank 1, motor 41 should be turned off and valve opened. The residual liquid should be discharged through discharge pipe 13, and then tank 1 should be rinsed with solvent.

[0036] Example 2

[0037] The difference from Embodiment 1 is that this embodiment discloses a stirring mechanism 2 and an auxiliary stirring mechanism 3 inside the tank 1;

[0038] The stirring mechanism 2 includes a stirring shaft 21 and first stirring blades 22. The stirring shaft 21 is rotatably connected to the upper part of the tank 1. Multiple first stirring blades 22 are provided and fixedly connected to the side wall of the stirring shaft 21 at equal intervals.

[0039] The stirring mechanism 2 also includes a mounting block 23 and a second stirring blade 25. The mounting block 23 is fixedly connected to the lower side wall of the stirring shaft 21. A connecting rod 24 is fixedly connected to the lower end of the mounting block 23. The lower end of the connecting rod 24 passes through the tank 1 and is rotatably connected to it. Multiple second stirring blades 25 are provided and are fixedly connected at equal intervals to the side wall of the connecting rod 24.

[0040] The auxiliary stirring mechanism 3 includes a transmission rod 31 and a rotating rod 32. The transmission rod 31 is located inside the stirring shaft 21 and is rotatably connected to it. There is a pair of rotating rods 32, which are rotatably connected to the end of the mounting block 23. The rotating rod 32 located above the mounting block 23 has a spiral blade 33 fixedly connected to its side wall. The two rotating rods 32 are respectively connected to the transmission rod 31 through a pulley assembly 34, which is located inside the mounting block 23.

[0041] In this embodiment, as Figures 4-5 As shown, the stirring shaft 21 and the transmission rod 31 are driven to rotate in opposite directions by the driving mechanism 4; the stirring shaft 21 rotates at a constant speed, the first stirring blade 22 generates radial flow, and pushes the material to the tank wall; the connecting rod 24 rotates synchronously with the stirring shaft 21, and the lower end of the second stirring blade 25 generates axial flow near the bottom of the tank, lifts the deposited particles upward, and forms a circulating flow after merging with the radial flow.

[0042] The rotation of the transmission rod 31 is transmitted to the left and right rotating rods 32 via the pulley assembly 34. The rotating rods 32 drive the spiral blades 33 to rotate, forming a local small circulation in the area near the tank wall, reducing dead zones. The two flows superimpose, so that the fresh material is quickly drawn into the mainstream area after entering from the feed pipe 11, and is fully homogenized with the liquid in the vessel.

[0043] Example 3

[0044] The difference from Embodiment 2 is that this embodiment discloses a drive mechanism 4 for simultaneously driving the stirring mechanism 2 and the auxiliary stirring mechanism 3;

[0045] The drive mechanism 4 includes a motor 41 and a first bevel gear 42. The motor 41 is fixedly connected to the upper end of the tank 1 by a mounting bracket. The first bevel gear 42 is fixedly connected to the output shaft end of the motor 41. The upper and lower side walls of the first bevel gear 42 are meshed with second bevel gears 43. The second bevel gear 43 located above the first bevel gear 42 is fixedly connected to the upper side wall of the rotating rod 32. The second bevel gear 43 located below the first bevel gear 42 is fixedly connected to the upper side wall of the stirring shaft 21.

[0046] In this embodiment, as Figure 3 As shown, by supplying power to the motor 41, the first bevel gear 42 is driven to rotate, and the rotation of the first bevel gear 42 drives the second bevel gear 43 to rotate. Since the second bevel gears 43 are symmetrical to each other, the two second bevel gears 43 rotate in opposite directions, thereby providing power to drive the stirring shaft 21 and the transmission rod 31 to rotate in opposite directions.

[0047] The working principle of this utility model is as follows:

[0048] After the motor 41 is powered on, its output shaft drives the first bevel gear 42 to rotate synchronously. The first bevel gear 42 simultaneously meshes with the upper and lower second bevel gears 43. Because the meshing directions are opposite, the two second bevel gears 43 rotate in opposite directions. The upper second bevel gear 43 transmits torque to the rotating rod 32 through the transmission rod 31, while the lower second bevel gear 43 directly drives the stirring shaft 21, thereby realizing the opposite rotation of the stirring shaft 21 and the transmission rod 31.

[0049] The stirring shaft 21 drives the first stirring blade 22 to form a radial shear flow at the top of the tank 1, and the connecting rod 24 and the second stirring blade 25 form an axial upward flow at the bottom. The two superimposed form a large circulation that runs through the tank 1, which quickly and evenly disperses the newly fed material. The transmission rod 31 drives the two rotating rods 32 to rotate at high speed through the pulley assembly 34. The spiral blade 33 generates a downward spiral microcirculation in the area near the tank wall, which continuously peels off the material attached to the wall and weakens the dead corners, further refining the residence time distribution.

[0050] During the reaction, the initial solvent and fresh material are continuously injected simultaneously through the feed pipe 11, and the liquid level gradually rises. When the liquid reaches the height of the overflow pipe 12, the product automatically overflows at the same flow rate, and the system enters steady-state continuous operation. When the reaction ends or cleaning is required, the motor 41 is turned off, the valve is opened, and the residual liquid is quickly discharged through the discharge pipe 13. Then, the cleaning solvent is injected, and the tank wall is flushed by the still rotating blades, achieving efficient and convenient online cleaning.

[0051] Although the disclosure is as stated above, the scope of protection of this disclosure is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of this disclosure, and all such changes and modifications will fall within the protection scope of this utility model.

Claims

1. A convenient and efficient continuous reaction device, comprising a tank (1), characterized in that, A feed pipe (11) is fixedly connected to the outer wall of the left side of the middle part of the tank (1), and an overflow pipe (12) is fixedly connected to the outer wall of the right side of the tank (1); it also includes: A stirring mechanism (2) is installed inside the tank (1) and is used to fully mix the materials inside the tank (1). An auxiliary stirring mechanism (3) is installed on the left and right sides of the stirring mechanism (2); A drive mechanism (4) is installed on the upper end of the tank (1) and is used to provide power for the operation of both the stirring mechanism (2) and the auxiliary stirring mechanism (3).

2. The convenient and efficient continuous reaction device according to claim 1, characterized in that, The stirring mechanism (2) includes a stirring shaft (21) and a first stirring blade (22). The stirring shaft (21) is rotatably connected to the upper part of the tank (1). Multiple first stirring blades (22) are provided and are fixedly connected to the side wall of the stirring shaft (21) at equal intervals.

3. The convenient and efficient continuous reaction device according to claim 1, characterized in that, The stirring mechanism (2) further includes a mounting block (23) and a second stirring blade (25). The mounting block (23) is fixedly connected to the lower side wall of the stirring shaft (21). A connecting rod (24) is fixedly connected to the lower end of the mounting block (23). The lower end of the connecting rod (24) passes through the tank (1) and is rotatably connected to it. Multiple second stirring blades (25) are provided and are fixedly connected at equal intervals to the side wall of the connecting rod (24).

4. The convenient and efficient continuous reaction device according to claim 1, characterized in that, The auxiliary stirring mechanism (3) includes a transmission rod (31) and a rotating rod (32). The transmission rod (31) is located inside the stirring shaft (21) and is rotatably connected to it. There is a pair of rotating rods (32) and they are rotatably connected to the end of the mounting block (23). The rotating rod (32) located above the mounting block (23) has a spiral blade (33) fixedly connected to its side wall. The two rotating rods (32) are respectively connected to the transmission rod (31) through a pulley assembly (34). The pulley assembly (34) is located inside the mounting block (23).

5. The convenient and efficient continuous reaction device according to claim 1, characterized in that, The drive mechanism (4) includes a motor (41) and a first bevel gear (42). The motor (41) is fixedly connected to the upper end of the tank (1) by a mounting bracket. The first bevel gear (42) is fixedly connected to the output shaft end of the motor (41). The upper and lower side walls of the first bevel gear (42) are meshed with second bevel gears (43). The second bevel gear (43) located above the first bevel gear (42) is fixedly connected to the upper side wall of the rotating rod (32). The second bevel gear (43) located below the first bevel gear (42) is fixedly connected to the upper side wall of the stirring shaft (21).

6. The convenient and efficient continuous reaction device according to claim 1, characterized in that, The height between the feed inlet of the feed pipe (11) and the top of the tank (1) is greater than the height between the overflow pipe (12) and the top of the tank (1). The bottom of the tank (1) is fixedly connected to the discharge pipe (13), and the side wall of the discharge pipe (13) is fixedly connected to the valve.

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