A grinding device for biopharmaceuticals

Abstract

The utility model discloses a kind of biological pharmaceutical grinding devices, it relates to the field of biotechnology, specifically a kind of biological pharmaceutical grinding device, including box, rotatingly connected with the shaft in the middle of box, fixedly connected with rotor on the shaft, sleeve is arranged outside rotor, sleeve front and back sidewall is fixedly connected with box, spiral thread texture is equipped on the surface of rotor, circular protruding block is equipped in the surface of sleeve, spiral texture of rotor and circular protruding block of sleeve are completely broken and ground to biological medicine, reduce medicine particle size, collecting hopper below is equipped with grinding tunnel, grinding block is slidably connected in grinding tunnel, grinding block is cooperated with grinding tunnel, make grinding block slide in grinding tunnel, to its material after being broken and ground by rotor and sleeve again plane reciprocating grinding is carried out, further reduce medicine particle size, greatly improve its output rate, improve production efficiency, save working time.

Description

Technical Field

[0001] This utility model relates to the field of biotechnology, specifically a grinding device for biopharmaceutical applications. Background Technology

[0002] With the rapid advancement of biotechnology in my country, biopharmaceutical manufacturing is a crucial step in drug production. Grinding devices are essential in biopharmaceutical processing. The essence of biopharmaceutical grinding is to reduce the size of drug particles through mechanical force, increasing their specific surface area, thereby improving the dissolution rate and bioavailability of poorly soluble drugs. This is vital for 70-90% of new chemical entities (which have low bioavailability due to poor water solubility). Existing devices can only perform grinding; subsequent screening and grading often results in incomplete grinding, leading to poor-quality materials requiring re-grinding and reprocessing, increasing costs and reducing drug yield. Therefore, we propose a grinding device for biopharmaceutical manufacturing. Utility Model Content

[0003] This invention provides a grinding device for biopharmaceutical applications, which solves the problems mentioned in the background art.

[0004] To achieve the above objectives, this utility model provides the following technical solution: A grinding device for biopharmaceutical applications includes a housing. A rotating shaft is rotatably connected to the upper center of the housing. A rotor is fixedly connected to the rotating shaft inside the housing. A sleeve is provided on the outer side of the rotor. The front and rear side walls of the sleeve are fixedly connected to the inner side wall of the housing. The outer surface of the rotor has a spiral thread texture. The inner surface of the sleeve has a circular protrusion. A collection hopper is installed directly below the sleeve. An inclined grinding tunnel is installed below the collection hopper. A grinding block is slidably connected inside the grinding tunnel. A through-type sliding groove is opened on the upper side wall of the grinding tunnel. A second fixing block is installed on the upper surface of the grinding block. The second fixing block passes through the sliding groove and protrudes above the upper side wall of the grinding tunnel. When the second fixing block moves along the sliding groove, it can drive the grinding block to move.

[0005] Preferably, a fixing block is installed on the four sides of the outer surface of the sleeve, and the fixing block is fixedly connected to the inner side wall of the box. A feed inlet is installed on the top of the sleeve, and the feed inlet communicates with the inside of the sleeve.

[0006] Preferably, a screen is fixedly connected to the lower outlet of the grinding tunnel, and the screen can screen the material after it has been ground by the grinding blocks.

[0007] Preferably, a fine material collection box is provided directly below the screen, and a coarse material collection box is provided at the screen outlet. The fine material collection box and the coarse material collection box are inserted into the box body and placed directly below the screen and at the outlet.

[0008] Preferably, a slider is slidably inserted at the connection between the sleeve and the collecting hopper. After insertion, the slider can form a complete circle with the sleeve. The upper surface of the slider is the same as the inner surface of the sleeve, and the slider passes through the front side wall of the box.

[0009] Preferably, a fixed platform is installed on one side of the chute on the upper sidewall of the grinding tunnel. A motor is installed on the top of the fixed platform. The output shaft of the motor is fixedly connected to a crank. A connecting rod is rotatably connected to the end of the crank. A fixed block is rotatably connected to the other end of the connecting rod.

[0010] Preferably, a support platform is installed in the middle of the rear side wall of the housing, and a second motor is installed on the upper surface of the support platform. The output shaft of the second motor is fixedly connected to the rotating shaft.

[0011] Preferably, a handle is installed in the middle of the front side wall of the coarse material collection box and the fine material collection box.

[0012] This utility model has the following beneficial effects: 1. This grinding device for biopharmaceuticals has a rotor fixedly connected to the shaft inside the housing. A sleeve is provided on the outside of the rotor, and the front and rear side walls of the sleeve are fixedly connected to the inner side wall of the housing. The rotor and the sleeve cooperate to crush and grind the added biopharmaceutical. The outer surface of the rotor has a spiral thread texture, and the inner surface of the sleeve has a circular protrusion. The spiral thread texture on the rotor surface and the circular protrusion on the inner surface of the sleeve cooperate to further crush and grind the biopharmaceutical thoroughly, making the grinding more complete and reducing the size of the ground drug particles.

[0013] 2. This biopharmaceutical grinding device has an inclined grinding tunnel installed below the collection hopper. Grinding blocks are slidably connected inside the grinding tunnel. A through-type sliding groove is opened on the upper side wall of the grinding tunnel. A second fixing block is installed on the upper surface of the grinding block. The second fixing block passes through the sliding groove and protrudes above the upper side wall of the grinding tunnel. When the second fixing block moves along the sliding groove, it can drive the grinding block to move. Through the cooperation between the grinding block and the grinding tunnel, the grinding block slides in the grinding tunnel, and performs planar reciprocating grinding on the material above it that has been crushed and ground by the rotor and sleeve. This further reduces the size of drug particles, greatly improves its yield, increases production efficiency, and saves working time. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a schematic diagram of the internal structure of this utility model; Figure 3 This is a schematic diagram of the crushing and grinding mechanism of this utility model; Figure 4 This is a schematic diagram of the driving structure of this utility model; In the diagram: 1. Box body; 2. Coarse material collection box; 3. Fine material collection box; 4. Slider; 5. Rotating shaft; 6. Feed inlet; 7. Fixed block one; 9. Screen; 10. Rotor; 11. Sleeve; 12. Collection hopper; 13. Grinding tunnel; 14. Grinding block; 15. Connecting rod; 16. Crank; 17. Motor one; 18. Fixed platform; 19. Support platform; 20. Motor two. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] Please see Figures 1 to 3 To achieve convenient operation, reduce the size of drug particles and gears, increase yield, improve production efficiency, and save working time, this application provides a grinding device for biopharmaceuticals. The grinding device includes a housing 1, with a rotating shaft 5 rotatably connected to the upper middle of the housing 1. A rotor 10 is fixedly connected to the rotating shaft 5 inside the housing 1. A sleeve 11 is provided on the outer side of the rotor 10, and the front and rear sidewalls of the sleeve 11 are fixedly connected to the inner sidewall of the housing 1. The outer surface of the rotor 10 has a spiral thread texture, and the inner surface of the sleeve 11 has a circular protrusion. A collection hopper 12 is installed directly below the sleeve 11, and an inclined grinding tunnel 13 is installed below the collection hopper 12. A grinding block 14 is slidably connected inside the grinding tunnel 13. A through-type groove is opened on the upper sidewall of the grinding tunnel 13. A fixing block 2 is installed on the upper surface of the grinding block 14, passing through the groove and protruding above the upper sidewall of the grinding tunnel 13. When the fixing block 2 moves along the groove, it can drive the grinding block 14 to move.

[0017] Based on the above, the rotating shaft 5 receives power and drives the rotor 10 to rotate. The spiral thread texture on the outer surface of the rotor 10 cooperates with the circular protrusion on the inner surface of the sleeve 11 to form the first coarse grinding system. Through shearing, squeezing and pushing, the material is initially crushed and guided to the collection hopper 12. The collection hopper 12 guides the coarsely ground material into the inclined grinding tunnel 13. The movement of the fixed block 2 along the slide groove drives the grinding block 14 to slide in the grinding tunnel 13, forming the second fine grinding system to achieve secondary refinement of the material. Furthermore, compared to traditional single grinding, it significantly improves the thoroughness of grinding, reduces the size of drug particles, and lays the foundation for improving drug dissolution rate and bioavailability. The inclined grinding tunnel 13 works in conjunction with the sliding grinding block 14 to avoid material accumulation and ensure grinding uniformity.

[0018] Please see Figures 1 to 2A fixing block 7 is installed around the outer circumference of the sleeve 11. The fixing block 7 is fixedly connected to the inner side wall of the box 1. A feed inlet 6 is installed on the top of the sleeve 11. The feed inlet 6 is connected to the inside of the sleeve 11.

[0019] Based on the above, the fixing block 7 uses a four-point fixing method to stably limit the sleeve 11 in the box, ensuring that the sleeve 11 and the rotor 10 always maintain a uniform grinding gap, avoiding the sleeve from shifting due to vibration during device operation. The feed port 6 above the sleeve 11 can accurately put the material into the grinding chamber. Furthermore, the multi-point fixing improves the installation stability of the sleeve 11, prevents uneven coarse grinding caused by changes in the grinding gap, ensures the consistency of particle refinement in the coarse grinding stage, and reduces material grinding quality fluctuations caused by component misalignment.

[0020] Please see Figures 1 to 2 A screen 9 is fixedly connected to the lower outlet of the grinding tunnel 13. The screen 9 can screen the material after it has been ground by the grinding block 14.

[0021] Based on the above, the screen 9 is set at the outlet end of the finely ground material. It uses the difference in pore size to separate qualified fine material with particle size smaller than the pore size from unqualified coarse material with particle size larger than the pore size in real time, so as to realize the simultaneous grinding and screening. Furthermore, it eliminates the need for additional grading steps after grinding in traditional equipment, shortens the production process, reduces material transfer losses, and enables immediate screening to quickly separate coarse materials, facilitating subsequent rework, reducing repeated grinding costs, and improving production efficiency.

[0022] Please see Figures 1 to 2 A fine material collection box 3 is set directly below the screen 9, and a coarse material collection box 2 is set at the outlet of the screen 9. The fine material collection box 3 and the coarse material collection box 2 are inserted into the box body 1 and placed directly below the screen 9 and at the outlet.

[0023] Based on the above, the fine material collection box 3 receives qualified fine material passing through the screen, and the coarse material collection box 2 collects unqualified coarse material at the outlet of the screen 9. The fine material collection box 3 and the coarse material collection box 2 can be quickly pulled out of the box body 1 to discharge the material. Furthermore, the insertable collection box structure facilitates quick and easy loading and unloading, reduces equipment downtime, prevents material accumulation and overflow within the collection box, improves the convenience and safety of material collection, and reduces material waste.

[0024] Please see Figures 1 to 3 A slider 4 is slidably inserted at the connection between the sleeve 11 and the collecting hopper 12. After the slider 4 is inserted, it can form a complete circle with the sleeve 11. The upper surface of the slider 4 is the same as the inner surface of the sleeve 11, and the slider 4 passes through the front side wall of the box 1.

[0025] Based on the above, when the slider 4 is inserted, it forms a complete arc-shaped inner wall with the inner surface of the sleeve 11, closing the conveying channel of the coarse grinding material to the collection hopper 12. The material can continue to be ground between the rotor 10 and the sleeve 11. When the slider 4 is pulled out, the channel opens, and the material enters the fine grinding stage along the collection hopper 12, realizing the on-off control of material conveying. Furthermore, by adjusting the material conveying rhythm by sliding slider 4, the material residence time can be extended according to the coarse grinding effect (such as closing the slider when coarse grinding is insufficient), thereby improving the thoroughness of coarse grinding. Slider 4 is adapted to the inner wall of sleeve 11 to avoid material residue at the connection, reduce material waste, and lower the difficulty of cleaning.

[0026] Please see Figures 1 to 3 A fixed platform 18 is installed on the upper side wall of the grinding tunnel 13 on one side of the slide groove. A motor 17 is installed on the top of the fixed platform 18. A crank 16 is fixedly connected to the output shaft of the motor 17. A connecting rod 15 is rotatably connected to the end of the crank 16. A fixed block 2 is rotatably connected to the other end of the connecting rod 15.

[0027] Based on the above, the fixed platform 18 provides a stable mounting base for the motor 17. The motor 17 drives the crank 16 to make circular motion. The crank 16 converts the circular motion into the linear reciprocating motion of the fixed block 2 through the connecting rod 15, thereby driving the grinding block 14 to slide back and forth in the tunnel, providing power for fine grinding. Furthermore, the transmission structure of motor 17, crank 16, and connecting rod 15 can stably convert power, ensuring uniform movement speed of the grinding block and stable grinding force, avoiding differences in fine grinding effect. The fixed table 18 reduces the impact of motor 17 vibration on the tunnel, ensures fine grinding accuracy, and reduces the operating noise of the device.

[0028] Please see Figures 1 to 4 A support platform 19 is installed in the middle of the rear side wall of the housing 1. A motor 20 is installed on the upper surface of the support platform 19. The output shaft of the motor 20 is fixedly connected to the rotating shaft 5.

[0029] Based on the above, the support 19 provides a fixed support for the motor 20, and the output shaft of the motor 20 directly drives the rotating shaft 5 to rotate. The rotating shaft 5 drives the rotor 10 to rotate synchronously, providing stable rotational power for rough grinding. Furthermore, the motor 20 is directly connected to the rotating shaft 5, reducing power transmission loss, ensuring stable rotor speed, and making the material uniformly stressed during coarse grinding. The support platform 19 isolates the vibration of the motor 20 from the housing, reducing the overall vibration amplitude of the device, extending the service life of components, and improving operational safety.

[0030] Please see Figure 1 Handles are installed in the middle of the front side wall of coarse material collection box 2 and fine material collection box 3.

[0031] Based on the above, the handle provides a gripping point for the operator, making it easy to pull out the coarse material collection box 2 and the fine material collection box 3 from the box 1, so as to realize the removal of qualified fine materials and the rework and transfer of unqualified coarse materials. Furthermore, the handle structure enhances the ease of picking up and placing the collection box, shortens the material cleaning and transfer time, further improves production efficiency, avoids material spillage when picking up the box due to the lack of a grip point, reduces material waste, and lowers the difficulty of operation.

[0032] In summary, this biopharmaceutical grinding device, during use, has a rotating shaft 5 rotatably connected to the upper middle of the housing 1. A rotor 10 is fixedly connected to the rotating shaft 5 inside the housing. A sleeve 11 is provided on the outer side of the rotor 10, and the front and rear side walls of the sleeve 11 are fixedly connected to the inner side wall of the housing 1. The rotor 10 and the sleeve 11 cooperate to crush and grind the added biopharmaceutical. The outer surface of the rotor 10 has a spiral thread texture, and the inner surface of the sleeve 11 has a circular protrusion. The cooperation between the spiral thread texture on the surface of the rotor 10 and the circular protrusion on the inner surface of the sleeve 11 further thoroughly crushes and grinds the biopharmaceutical, making the grinding more complete, reducing the size of the ground drug particles, and collecting the product. A slanted grinding tunnel 13 is installed below the bucket 12. A grinding block 14 is slidably connected inside the grinding tunnel 13. A through-type sliding groove is opened on the upper side wall of the grinding tunnel 13. A fixing block 2 is installed on the upper surface of the grinding block 14. The fixing block 2 passes through the sliding groove and is higher than the upper side wall of the grinding tunnel 13. When the fixing block 2 moves along the sliding groove, it can drive the grinding block 14 to move. Through the cooperation between the grinding block 14 and the grinding tunnel 13, the grinding block 14 slides in the grinding tunnel 13, and performs planar reciprocating grinding on the material above it that has been crushed and ground by the rotor 10 and the sleeve 11, further reducing the size of drug particles, greatly improving its output rate, increasing production efficiency, and saving working time.

[0033] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model; the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. In addition, unless otherwise explicitly specified and limited, the terms "installed," "connected," and "linked" should be interpreted broadly. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. For those skilled in the art, the specific meaning of the above terms in this utility model can be understood according to the specific circumstances. Moreover, the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0034] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A grinding device for biopharmaceutical applications, comprising a housing (1), characterized in that: The upper middle of the box (1) is rotatably connected to a rotating shaft (5). A rotor (10) is fixedly connected to the rotating shaft (5) inside the box (1). A sleeve (11) is provided on the outside of the rotor (10). The front and rear side walls of the sleeve (11) are fixedly connected to the inner side wall of the box (1). The outer surface of the rotor (10) is provided with a spiral thread texture. The inner surface of the sleeve (11) is provided with a circular protrusion. A collection hopper (12) is installed directly below the sleeve (11). An inclined grinding tunnel (13) is installed below the collection hopper (12). A grinding block (14) is slidably connected inside the grinding tunnel (13). A through-type sliding groove is opened on the upper side wall of the grinding tunnel (13). A fixing block two is installed on the upper surface of the grinding block (14). The fixing block two passes through the sliding groove and is higher than the upper side wall of the grinding tunnel (13). When the fixing block two moves along the sliding groove, it can drive the grinding block (14) to move.

2. The grinding apparatus for biopharmaceutical use according to claim 1, characterized in that: A fixing block 1 (7) is installed on the four sides of the outer surface of the sleeve (11). The fixing block 1 (7) is fixedly connected to the inner side wall of the box (1). A feed port (6) is installed on the top of the sleeve (11). The feed port (6) is connected to the inside of the sleeve (11).

3. The grinding apparatus for biopharmaceutical use according to claim 2, characterized in that: A screen (9) is fixedly connected to the lower outlet of the grinding tunnel (13), and the screen (9) can screen the material after it has been ground by the grinding block (14).

4. The grinding apparatus for biopharmaceutical use according to claim 3, characterized in that: A fine material collection box (3) is provided directly below the screen (9), and a coarse material collection box (2) is provided at the outlet of the screen (9). The fine material collection box (3) and the coarse material collection box (2) are inserted into the box body (1) and placed directly below the screen (9) and at the outlet.

5. The grinding apparatus for biopharmaceutical use according to claim 4, characterized in that: A slider (4) is slidably inserted at the connection between the sleeve (11) and the collection hopper (12). After the slider (4) is inserted, it can form a complete circle with the sleeve (11). The upper surface of the slider (4) is the same as the inner surface of the sleeve (11), and the slider (4) passes through the front side wall of the box (1).

6. The grinding apparatus for biopharmaceutical use according to claim 5, characterized in that: A fixed platform (18) is installed on the upper side wall of the grinding tunnel (13) on one side of the slide groove. A motor (17) is installed on the top of the fixed platform (18). A crank (16) is fixedly connected to the output shaft of the motor (17). A connecting rod (15) is rotatably connected to the end of the crank (16). A fixed block (2) is rotatably connected to the other end of the connecting rod (15).

7. The grinding apparatus for biopharmaceutical use according to claim 6, characterized in that: A support platform (19) is installed in the middle of the rear side wall of the box (1), and a second motor (20) is installed on the upper surface of the support platform (19). The output shaft of the second motor (20) is fixedly connected to the rotating shaft (5).

8. The grinding apparatus for biopharmaceutical use according to claim 7, characterized in that: Handles are installed in the middle of the front side wall of the coarse material collection box (2) and the fine material collection box (3).

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