Automatic cell separation, preparation, staining and dyeing integrated machine

Abstract

The utility model discloses an automatic cell separation sectioning and dyeing integrated machine relates to sectioning and dyeing technical field, including organism, the front side of organism is provided with operation cavity, rotates and installs on the inside lateral wall of operation cavity and has the rotating table, the upper end surface of rotating table is slidably installed with the lifting plate, the upper end surface of rotating table is provided with a plurality of containing groove, and the inside installation of containing groove has the glass slide, and the position of lifting plate on corresponding glass slide all are fixedly installed with the dyeing bin, the inside top of operation cavity is detachably provided with the transverse board, and the bottom of transverse board corresponds the position of dyeing bin all and is fixedly installed with the dyeing needle. Linkage mechanism makes gear drive tooth plate to go up, thereby promotes lifting plate and dyeing bin. Make the glass slide completely expose, and it is convenient to take and change, simultaneously, and the dyeing bin that removes provides the barrier -free export of containing groove, ensures that waste liquid can be completely poured and collected under the action of rotating centrifugal force or gravity, effectively prevents liquid cross -contamination, guarantees sectioning quality.

Description

Technical Field

[0001] This utility model relates to the field of slide preparation and staining technology, and more specifically, it relates to an automatic cell separation, slide preparation and staining integrated machine. Background Technology

[0002] Liquid-based cell smear technology involves adhering useful cells to be diagnosed onto the surface of a glass slide, forming a cell sheet on the slide. The cells in the cell sheet are neat and uniform, with a clear single-layer tiling background and no interference from red blood cells or mucus, making it convenient for diagnostic personnel to use in clinical diagnosis.

[0003] Chinese Patent CN213022545U discloses an integrated cell separation, slide preparation, and staining machine. The machine includes a base, several glass slides on the base, staining chambers on the slides, and several staining needles for dispensing staining agents. It also includes a collection tank, several conveyor platforms, and a support mounted on the base. The support has a drive assembly that drives the staining needles to slide perpendicular to the length of the collection tank. The base has a groove for housing the collection tank, and the two side walls adjacent to the groove opening have sliding grooves. Within these grooves are conveying components that drive the conveyor platforms to slide along the length of the collection tank, and a liquid-discharging component that drives the conveyor platforms to tilt. This integrated staining machine effectively emptys the waste liquid in the staining chambers, preventing cross-contamination between different liquids during re-injection and ensuring slide quality.

[0004] Regarding the aforementioned technologies, the inventors believe they suffer from the following drawbacks: Firstly, because the staining chamber is fixed within the receiving tank and remains in close contact with the slide, slide replacement is inconvenient. The fixed staining chamber restricts the operating space, making the process of removing stained slides and inserting new slides cumbersome and inefficient. Secondly, this close-fitting structure hinders the smooth discharge of waste liquid; the chamber itself obstructs the waste liquid's outflow path, making it difficult to completely empty the waste liquid. Residual waste liquid that is not completely drained will mix with newly injected liquid, causing cross-contamination between different liquids. This fundamental flaw directly affects the subsequent slide preparation quality and reliability. Utility Model Content

[0005] Technical problems to be solved In view of the problems existing in the prior art, this utility model provides an automatic cell separation, slide preparation and staining integrated machine to solve the problems mentioned in the background art.

[0006] (II) Technical Solution To achieve the above objectives, this utility model provides the following technical solution: an automatic cell separation, slide preparation, and staining integrated machine, comprising a body, an operating cavity on the front side of the body, a rotating platform rotatably mounted on the inner side wall of the operating cavity, a lifting plate slidably mounted on the upper end surface of the rotating platform, multiple receiving slots on the upper end surface of the rotating platform, glass slides installed inside the receiving slots, and staining chambers fixedly mounted on the lifting plate at positions corresponding to the glass slides; a horizontal plate movable at the top of the operating cavity, and staining needles fixedly mounted at the bottom end of the horizontal plate at positions corresponding to the staining chambers; first gears rotatably mounted on both sides of the upper end surface of the rotating platform, and toothed plates fixedly mounted on the lower end surface of the lifting plate at positions corresponding to the first gears, the toothed plates being slidably connected to the rotating platform and meshing with the first gears; and a linkage component for driving the first gears to rotate is provided on the inner wall of the operating cavity. The present invention is further configured such that rotating shafts are rotatably installed on both sides of the inner wall of the operating cavity, and a rotating table is fixedly installed on the opposite ends of the rotating shafts on both sides; a motor is fixedly installed on the outer wall of the machine body, and the output shaft of the motor is fixedly connected to one side of the rotating shaft. The present invention is further configured such that the linkage component includes an internal gear ring, a rotating rod, and a second gear; the internal gear ring is fixedly installed on the inner wall of the operating cavity, and the rotating rod is rotatably installed on the inner wall of the operating cavity; a second gear is fixedly installed at one end of the rotating rod, and the second gear meshes with the internal gear ring; the other end of the rotating rod is fixedly connected to the first gear; a linkage plate is fixedly installed on the rotating shaft, and the linkage plate is rotatably connected to the rotating rod. The present invention is further configured such that a sliding door is slidably installed on the front side of the operating cavity, a locking block is slidably installed on the top front side of the sliding door, and a loop groove is opened on the top front side of the machine body, with the locking block engaging with the loop groove. The present invention is further configured such that a guide rail is provided on the inner top surface of the operating cavity, a slider is slidably installed inside the guide rail, a horizontal plate is fixedly connected to the slider, and a screw is rotatably installed inside the guide rail, and the screw is threadedly connected to the slider. The present invention is further configured such that guide rods are fixedly installed at the four corners of the upper end face of the rotating platform, and the lifting plate and the guide rods are slidably connected. The present invention is further configured such that a liquid storage tank is movably placed on the bottom surface of the inner side of the operating cavity.

[0007] (III) Beneficial Effects Compared with the prior art, this utility model provides an automatic cell separation, slide preparation and staining integrated machine, which has the following beneficial effects: This automated cell separation, slide preparation, and staining machine uses a screw-slider mechanism to drive the staining needles laterally for liquid injection. A linkage system consisting of a motor, rotating shaft, linkage plate, rotating rod, gear set, and toothed plate converts the rotational motion of the rotating table into the vertical lifting of the lifting plate. After the staining needles have injected liquid into all staining chambers, the motor starts, rotating the rotating table. Simultaneously, the linkage mechanism drives the gears to rise, thereby lifting the lifting plate and the staining chambers. This continuous action fully exposes the slides, facilitating easy handling and replacement. At the same time, the removed staining chambers provide an unobstructed outlet for the receiving tank, ensuring that waste liquid is completely poured out and collected under centrifugal force or gravity, effectively preventing cross-contamination and guaranteeing slide quality. Attached Figure Description

[0008] Figure 1 This is a schematic diagram of the structure from the front view of this utility model; Figure 2 This is a schematic diagram of the internal structure of this utility model; Figure 3 This is a partial structural diagram of the present invention; Figure 4 This is a partial cross-sectional view of the structure of this utility model; Figure 5 In this utility model Figure 4 Enlarged structural diagram at point A in the middle.

[0009] Reference numerals in the attached drawings: 1. Machine body; 2. Operating chamber; 3. Rotating table; 4. Lifting plate; 5. Receiving tank; 6. Glass slide; 7. Staining chamber; 8. Horizontal plate; 9. Staining needle; 10. Rotating shaft; 11. Motor; 12. First gear; 13. Gear plate; 14. Internal gear ring; 15. Rotating rod; 16. Second gear; 17. Linkage plate; 18. Sliding door; 19. Locking block; 20. U-shaped groove; 21. Guide rail; 22. Slider; 23. Screw; 24. Guide rod; 25. Liquid storage tank. Detailed Implementation

[0010] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0011] It should be noted that, unless otherwise specified, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains.

[0012] In this utility model, unless otherwise stated, the orientations used, such as "up" and "down", usually refer to the direction shown in the accompanying drawings, or to the vertical, perpendicular, or gravitational direction; similarly, for ease of understanding and description, "left" and "right" usually refer to the left and right shown in the accompanying drawings; "inner" and "outer" refer to the inner and outer contours of each component itself, but the above directional terms are not used to limit this utility model.

[0013] Please see Figures 1-5 An automated cell separation, slide preparation, and staining machine includes a body 1 with an operating chamber 2 on its front side. A sliding door 18 is slidably mounted on the front side of the operating chamber 2, and a locking block 19 is slidably mounted laterally on the top front side of the sliding door 18. A U-shaped groove 20 is formed on the top front side of the body 1, and the locking block 19 engages with the U-shaped groove 20. This facilitates the opening and closing of the operating chamber 2 and its subsequent sealing and fixation.

[0014] A rotating platform 3 is rotatably mounted on the inner side wall of the operating chamber 2. Multiple receiving slots 5 are formed on the upper surface of the rotating platform 3, and glass slides 6 are installed inside the receiving slots 5. Guide rods 24 are fixedly mounted at the four corners of the upper surface of the rotating platform 3, and lifting plates 4 are slidably connected to the guide rods 24. Lifting plates 4 are slidably mounted up and down on the upper surface of the rotating platform 3, and staining chambers 7 are fixedly mounted on the lifting plates 4 at positions corresponding to the glass slides 6. A motor 11 is fixedly mounted on the outer wall of the machine body 1. Rotating shafts 10 are rotatably mounted on both sides of the inner wall of the operating chamber 2. The rotating platform 3 is fixedly mounted at the opposite ends of the two rotating shafts 10, and the output shaft of the motor 11 is fixedly connected to one rotating shaft 10. This allows the rotating platform 3 to rotate smoothly and guides the lifting plates 4 to rise and fall stably.

[0015] A horizontal plate 8 is movable at the top of the operating chamber 2. Dyeing needles 9 are fixedly installed at the bottom of the horizontal plate 8, corresponding to the positions of the dyeing chambers 7. A guide rail 21 is provided on the top surface of the operating chamber 2. A slider 22 is slidably installed inside the guide rail 21. The horizontal plate 8 is fixedly connected to the slider 22. A screw 23 is rotatably installed inside the guide rail 21 and threadedly connected to the slider 22. The screw 23 is driven by a motor fixedly installed outside the machine body 1. This allows the dyeing needles 9 to move precisely and be aligned with each dyeing chamber 7 for injection.

[0016] A first gear 12 is rotatably mounted on both sides of the upper end face of the rotating platform 3. A toothed plate 13 is fixedly mounted on the lower end face of the lifting plate 4 at a position corresponding to the first gear 12. The toothed plate 13 is slidably connected to the rotating platform 3 and meshes with the first gear 12. A linkage assembly for driving the first gear 12 to rotate is provided on the inner wall of the operating chamber 2. The linkage assembly includes an internal gear ring 14, a rotating rod 15, and a second gear 16. The internal gear ring 14 is fixedly mounted on the inner wall of the operating chamber 2. The rotating rod 15 is rotatably mounted on the inner wall of the operating chamber 2. The second gear 16 is fixedly mounted on one end of the rotating rod 15 and meshes with the internal gear ring 14. The other end of the rotating rod 15 is fixedly connected to the first gear 12. A linkage plate 17 is fixedly mounted on the rotating shaft 10 and rotatably connected to the rotating rod 15. The rotational motion of the rotating platform 3 is converted into the stable lifting motion of the lifting plate 4, realizing the automatic lifting of the dyeing chamber 7.

[0017] A liquid storage tank 25 is movably placed on the bottom surface of the operating chamber 2. This structure facilitates the collection of poured waste liquid.

[0018] In summary, when using the overall equipment: At the start of the testing process, the motor driving the screw 23 is activated. The rotation of the motor causes the screw 23 to rotate, and the slider 22, which is threaded into the screw 23, slides horizontally within the guide rail 21. The movement of the slider 22 is transmitted to all the dyeing needles 9 via the horizontal plate 8, causing them to move synchronously as a whole. When the horizontal plate 8 moves to a preset position, ensuring that a particular dyeing needle 9 is accurately aligned with the target dyeing chamber 7 below it, the motor stops, and the dyeing needle 9 injects a specific dyeing liquid into that dyeing chamber 7. After this injection is completed, the motor restarts, driving the horizontal plate 8 to move the dyeing needle 9 directly above the next dyeing chamber 7, repeating the injection process until each dyeing chamber 7 on the lifting plate 4 has been sequentially injected with the required liquid according to the preset program.

[0019] After all the liquids in the dyeing chambers 7 have been injected and allowed to stand for the specified time, the next action sequence is initiated. At this time, the motor 11 is started, and its output shaft directly drives the rotating shaft 10 on one side to rotate. The rotation of the rotating shaft 10 simultaneously triggers two linked actions: first, the rotating shaft 10 drives the rotating table 3 fixed to it to rotate as a whole; second, the linkage plate 17 fixedly installed on the rotating shaft 10 also rotates accordingly. The rotation of the linkage plate 17 will push the rotating rod 15, which is rotatably connected to it, to revolve around its connection point with the inner wall of the operating chamber 2. Since the second gear 16 fixedly installed at one end of the rotating rod 15 is always in mesh with the internal gear ring 14 fixed to the inner wall of the operating chamber 2, the revolve motion of the rotating rod 15 forces the second gear 16 to roll along the internal gear ring 14, thereby generating its own rotation. This rotational motion is transmitted through the rotating rod 15 to the first gear 12 fixedly connected to its other end, causing the first gear 12 to rotate.

[0020] The rotating first gear 12 interacts with the meshing toothed plate 13. Since the toothed plate 13 and the rotating platform 3 are in a sliding connection relationship, and its movement is constrained by the guide rod 24, the rotation of the first gear 12 is converted into the linear upward movement of the toothed plate 13. The paired toothed plates 13 move upward synchronously, jointly pushing the lifting plate 4 fixed to them to slide smoothly upward along the guide rod 24, thereby lifting all the dyeing chambers 7 together with the lifting plate 4, completely separating them from the originally fitted receiving tank 5. The lifting action of the dyeing chambers 7 produces two key effects: First, it completely exposes the glass slides 6 fixed in the receiving tank 5, making them easy to remove and replace; second, the removal of the dyeing chambers 7 opens an unobstructed outlet for the receiving tank 5, allowing the waste liquid remaining in the receiving tank 5 after the static reaction to be completely and smoothly poured into the movable storage tank 25 below for unified collection under the centrifugal force generated by the rotation of the rotating platform 3 or its own gravity. This series of automated actions effectively avoids cross-contamination that may occur between different batches or types of liquids due to residues, significantly improving the stability and quality of the film production.

[0021] Of all the solutions mentioned above, those involving the connection between two components can be selected according to the actual situation, such as welding, bolt and nut connection, bolt or screw connection, or other known connection methods, which will not be elaborated here. For all the fixed connections mentioned above, welding is preferred. Although embodiments of this utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this utility model. The scope of this utility model is defined by the appended claims and their equivalents.

Claims

1. An automated cell separation, slide preparation, and staining machine, comprising a body (1), wherein an operating cavity (2) is provided on the front side of the body (1), characterized in that, A rotating platform (3) is rotatably mounted on the inner side wall of the operating cavity (2). A lifting plate (4) is slidably mounted on the upper surface of the rotating platform (3). Multiple receiving slots (5) are opened on the upper surface of the rotating platform (3). A glass slide (6) is installed inside the receiving slot (5). A staining chamber (7) is fixedly installed on the lifting plate (4) at the position corresponding to the glass slide (6). A horizontal plate (8) is movably arranged at the top of the inside of the operating cavity (2). The bottom end of the horizontal plate (8) corresponds to the staining chamber. Dyeing needles (9) are fixedly installed at the position of the chamber (7); the first gear (12) is rotatably installed on both sides of the upper end face of the rotating table (3); the toothed plate (13) is fixedly installed on the lower end face of the lifting plate (4) at the position corresponding to the first gear (12); the toothed plate (13) is slidably connected to the rotating table (3); the toothed plate (13) is meshed with the first gear (12); the inner wall of the operating cavity (2) is provided with a linkage component for driving the first gear (12) to rotate.

2. The automatic cell separation, slide preparation, and staining integrated machine according to claim 1, characterized in that: The inner walls of the operating cavity (2) are rotatably mounted with rotating shafts (10) on both sides, and the rotating table (3) is fixedly mounted on the opposite ends of the rotating shafts (10) on both sides; a motor (11) is fixedly mounted on the outer wall of the machine body (1), and the output shaft of the motor (11) is fixedly connected to the rotating shaft (10) on one side.

3. The automatic cell separation, slide preparation, and staining integrated machine according to claim 1, characterized in that: The linkage assembly includes an internal gear ring (14), a rotating rod (15), and a second gear (16); the internal gear ring (14) is fixedly installed on the inner wall of the operating cavity (2), the rotating rod (15) is rotatably installed on the inner wall of the operating cavity (2), one end of the rotating rod (15) is fixedly installed with the second gear (16), and the second gear (16) meshes with the internal gear ring (14); the other end of the rotating rod (15) is fixedly connected with the first gear (12); a linkage plate (17) is fixedly installed on the rotating shaft (10), and the linkage plate (17) is rotatably connected with the rotating rod (15).

4. The automatic cell separation, slide preparation, and staining integrated machine according to claim 1, characterized in that: A sliding door (18) is slidably installed on the front side of the operating cavity (2). A locking block (19) is slidably installed on the top front side of the sliding door (18). A groove (20) is opened on the top front side of the body (1). The locking block (19) engages with the groove (20).

5. The automatic cell separation, slide preparation, and staining integrated machine according to claim 1, characterized in that: The operating cavity (2) has a guide rail (21) on its inner top surface. A slider (22) is slidably installed inside the guide rail (21). The horizontal plate (8) is fixedly connected to the slider (22). A screw (23) is rotatably installed inside the guide rail (21). The screw (23) is threadedly connected to the slider (22).

6. The automatic cell separation, slide preparation, and staining integrated machine according to claim 1, characterized in that: Guide rods (24) are fixedly installed at the four corners of the upper surface of the rotating platform (3), and the lifting plate (4) is slidably connected to the guide rods (24).

7. The automatic cell separation, slide preparation, and staining integrated machine according to claim 1, characterized in that: A liquid storage tank (25) is movably placed on the bottom surface of the operating chamber (2).

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