A novel norfloxacin production raw material sample detection device

Abstract

The utility model relates to a novel norfloxacin production with raw material sample detection device belongs to norfloxacin detection technical field, this novel norfloxacin production with raw material sample detection device, include: chromatograph body, the top of chromatograph body is provided with the enclosure baffle, limiting mechanism, the limiting mechanism sets up in the inside of enclosure baffle, the limiting mechanism includes the multiple sets of limiting lever of rotation connection in the inside of enclosure baffle, the surface of limiting lever is provided with two mutually interlocking adjusting lever, through the inside setting up multiple sets of'L'shape's limiting lever of enclosure baffle to solvent bottle carries out the limiting, makes staff after placing solvent bottle into each set of limiting lever, corresponding limiting lever will follow the merging, through the weight of solvent bottle self drive limiting lever and carry out the limiting to solvent bottle to prevent staff from touching the communicating pipe and thus pulling solvent bottle to cause to pour.

Description

Technical Field

[0001] This utility model relates to the field of norfloxacin detection technology, and in particular to a novel raw material sample detection device for norfloxacin production. Background Technology

[0002] Norfloxacin is a third-generation fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase. The testing of its raw material samples strictly follows pharmacopoeia standards, mainly including properties, identification, solution clarity and color, related substances, loss on drying, residue on ignition, and content determination, to ensure the safety, efficacy, and uniformity of the raw material. High-performance liquid chromatography (HPLC) is the primary detection device for norfloxacin.

[0003] Traditional high-performance liquid chromatographs (HPLC) use multiple solvent bottles containing mobile phase placed on top for detection. The solvent from these bottles is then introduced into the chromatograph via connecting tubes. However, traditional HPLC systems lack a device to limit the flow of the solvent bottles, and the connecting tubes are often misplaced. This can lead to accidental tipping of the solvent bottles by operators during testing, resulting in material loss. Utility Model Content

[0004] Therefore, it is necessary to provide a new type of raw material sample detection device for norfloxacin production, addressing the problem that the solvent bottle on top of traditional high-performance liquid chromatographs is prone to tipping over.

[0005] A novel sample testing device for raw materials used in norfloxacin production includes: a chromatograph body, the top of which is equipped with a baffle plate; A limiting mechanism is provided inside the enclosure panel. The limiting mechanism includes multiple sets of limiting rods rotatably connected inside the enclosure panel. The surface of each limiting rod is provided with two intersecting adjusting rods.

[0006] In one embodiment, the cross-section of the limiting rod is "L" shaped, and each set of the limiting rods consists of four limiting rods arranged in a "+" shape.

[0007] In one embodiment, the inner bottom wall of the enclosure is fixedly connected to a plurality of fixing blocks, and the inflection point of the limiting rod is rotatably connected to the fixing blocks.

[0008] In one embodiment, the surface of the limiting rod has two grooves, and a slider is slidably connected inside the groove, with the two sliders arranged opposite to each other.

[0009] In one embodiment, two adjusting rods located on the same surface of the limiting rod are provided with a rotating roller at one end away from the limiting rod, one end of the adjusting rod is hinged to the inner wall of the slider and the other end is hinged to the rotating roller.

[0010] In one embodiment, a slide rod is fixedly connected to the top of the slider, and the slide rod is inserted into the inner wall of the limiting rod and slidably connected to the inner wall of the limiting rod.

[0011] In one embodiment, a spring is sleeved around the slide bar, and the spring is fixedly connected between the inner wall of the limiting rod and the slider.

[0012] In one embodiment, the top end of the limiting rod is rotatably connected to a limiting roller, and the surface of the limiting roller has two annular tubes.

[0013] Beneficial effects 1. By setting multiple sets of "L"-shaped limiting rods inside the enclosure to limit the solvent bottle, after the worker places the solvent bottle into each set of limiting rods, the corresponding limiting rods will merge together. The weight of the solvent bottle itself will drive the limiting rods to limit the solvent bottle, thereby preventing the worker from accidentally touching the connecting pipe and pulling the solvent bottle, which would cause it to tip over. 2. By setting a rotating roller, adjusting rod and slider on the inner side of the limiting rod, the limiting mechanism can adaptively clamp and limit solvent bottles of different diameters, which improves the compatibility of the device with various specifications of solvents. The rolling guiding characteristics of the rotating roller make the placement and removal of solvent bottles smoother and less labor-intensive, which not only ensures the stable constraint of the solvent bottle, but also avoids the risk of container breakage due to excessive squeezing, greatly enhancing the practicality and operational safety of the device. 3. By setting a limiting roller at the top of the limiting rod and opening an annular groove on the surface of the limiting roller, the connecting pipes of each solvent bottle can be rationally planned, thereby improving the cleanliness of the connecting pipes and reducing the risk of workers accidentally touching the connecting pipes. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the installation of the limiting mechanism of this utility model; Figure 3This is a schematic diagram of the overall structure of the limiting mechanism of this utility model; Figure 4 This is an exploded view of the limiting mechanism of this utility model; Figure 5 This is a cross-sectional view of the limiting mechanism of this utility model.

[0016] Figure label: 100. Chromatograph body; 200. Enclosure plate; 300. Limiting mechanism; 310. Limiting rod; 311. Slide groove; 312. Limiting roller; 320. Adjusting rod; 321. Sliding block; 322. Slide bar; 323. Spring; 330. Rotating roller; 340. Fixing block. Detailed Implementation

[0017] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0018] The following is combined with Figures 1-5 This invention describes a novel raw material sample testing device for norfloxacin production.

[0019] In one embodiment, a novel sample testing device for raw materials used in norfloxacin production, such as... Figure 1 As shown, the novel raw material sample detection device for norfloxacin production in this embodiment includes: a chromatograph body 100, and a baffle plate 200 is provided on the top of the chromatograph body 100. The limiting mechanism 300 is located inside the enclosure 200. The limiting mechanism 300 includes multiple sets of limiting rods 310 rotatably connected inside the enclosure 200. The surface of the limiting rods 310 is provided with two intersecting adjusting rods 320.

[0020] In this device, the chromatograph body 100 mainly consists of five modules: an injection system, a delivery system, a separation system, a detection system, and a data processing system. The injection system, located at the front of the instrument, is responsible for accurately injecting the sample into the mobile phase flow path. The delivery system runs through the middle and rear of the instrument, using a high-pressure pump to deliver the mobile phase to the chromatographic column at a stable flow rate. The separation system, located in the core area of ​​the middle of the instrument, uses the stationary phase within the chromatographic column to separate the components in the sample. The detection system is immediately connected to the column outlet, using optical or electrochemical detectors to perform qualitative and quantitative analysis of the separated components. The data processing system is integrated into the host unit or connected to a computer, responsible for acquiring signals and generating chromatograms and analysis reports. Its working principle is as follows: the high-pressure pump delivers the mobile phase to the chromatographic column; the sample, injected by the injector, enters the column along with the mobile phase. Due to the differences in the partition coefficients of the components between the stationary and mobile phases, they migrate at different rates to achieve separation. The components eluting from the column are captured by the detector and converted into electrical signals, which are then analyzed by the data processing system to obtain quantitative results.

[0021] As shown in the figure Figure 3 , Figure 4 and Figure 5 As shown, the cross-section of the limiting rod 310 is "L" shaped. Each set of limiting rods 310 consists of four limiting rods 310 arranged in a "+" shape. Multiple fixing blocks 340 are fixedly connected to the inner bottom wall of the enclosure 200. The inflection points of the limiting rods 310 are rotatably connected to the fixing blocks 340. Two sliding grooves 311 are formed on the surface of the limiting rod 310. Sliding sliders 321 are slidably connected inside the sliding grooves 311. The two sliding sliders 321 are arranged opposite to each other and located on the same surface of the limiting rod 310. Two adjusting rods 320 are provided with a rotating roller 330 at the end away from the limiting rod 310. One end of the adjusting rod 320 is hinged to the inner wall of the slider 321 and the other end is hinged to the rotating roller 330. A sliding rod 322 is fixedly connected to the top of the slider 321. The sliding rod 322 is inserted into the inner wall of the limiting rod 310 and is slidably connected to the inner wall of the limiting rod 310. A spring 323 is sleeved around the sliding rod 322. The spring 323 is fixedly connected between the inner wall of the limiting rod 310 and the slider 321.

[0022] In this embodiment, the inner bottom wall of the baffle 200 has a certain thickness, and the inner bottom wall of the baffle 200 has multiple "+" shaped grooves corresponding to the limiting rod 310. When the limiting rod 310 is in the closed state, the part below the connection point between the limiting rod 310 and the fixing block 340 is located in the groove. At the same time, the bottom end of the limiting rod 310 is set with a smooth rounded corner. When the solvent bottle comes into contact with this part, this part will not cause damage to the bottom of the solvent bottle. When some solvent bottles with larger diameters are placed in... When the corresponding limiting rod 310 is inside, the surface of the solvent bottle will first contact the rotating roller 330, thereby avoiding direct contact with the limiting rod 310 and causing wear; when the limiting rod 310 is closed, the slider 321 will slide to the two ends of the slide groove 311. During this process, the slider 322 will always be in the inner wall of the limiting rod 310 and slide into the depth of the inner wall of the limiting rod 310. At this time, the spring 323 is compressed relatively evenly, and the reaction force of the spring 323 applies pressure to the solvent bottle, thereby stabilizing it; It should be noted that this device achieves the effect of limiting the solvent bottle by setting a limiting mechanism 300 at the top of the chromatograph body 100. Since this device is completely installed inside the baffle 200, it will not affect the installation of other components of the chromatograph. Therefore, the limiting mechanism 300 of this device will not affect the normal use of the chromatograph.

[0023] like Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, the top end of the limiting rod 310 is rotatably connected to the limiting roller 312, and the surface of the limiting roller 312 has two annular grooves.

[0024] In this embodiment, after the solvent bottle is installed, a suitable limiting roller 312 can be selected according to the direction of the connecting pipe, and the connecting pipe is passed through the groove of the limiting roller 312 while maintaining a slight tension on the connecting pipe, thereby making the connecting pipe neat and tidy. A connecting block is fixedly connected to one side of the top end of the limiting rod 310. The surface of the connecting block is rotatably connected to the limiting roller 312, so the limiting roller 312 is in a rotatable state on the limiting rod 310.

[0025] Working principle: The operator places the prepared solvent bottle directly into the middle of each set of limiting rods 310 and then releases it. At this time, the solvent bottle will move towards the inner bottom wall of the baffle plate 200 under its own gravity. During the movement of the solvent bottle, it will press the raised part at the end of the limiting rod 310. At this time, the limiting rod 310 will rotate along the fixed block 340, thereby driving the other end to close in the middle. During the closing process of the limiting rod 310, multiple rotating rollers 330 will simultaneously contact the surface of the solvent bottle and apply pressure through the limiting rod 310. At this time, the corresponding adjusting rod 320 on each limiting rod 310 will unfold to both ends along the slide groove 311 and compress the spring 323 through the slider 321. The spring force of the spring 323 and the adjusting rod 320 indirectly apply pressure to the rotating roller 330, so that the solvent bottle can be more stably positioned within each set of limiting rods 310. After the solvent bottle is installed and stabilized, its corresponding connecting pipe is straightened and organized by the limiting roller 312 at the top of the limiting rod 310, so that the connecting pipe is laid more neatly.

[0026] It should be noted that the chromatograph body 100 and spring 323 mentioned above are both devices with relatively mature existing technology. The specific model can be selected according to actual needs. At the same time, the chromatograph body 100 can be powered by the built-in power supply or by the mains power. The specific power supply method should be selected according to the situation, which will not be elaborated here.

[0027] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A novel norfloxacin production raw material sample detection device, characterized by, include: The chromatograph body (100) is provided with a baffle plate (200) on the top of the chromatograph body (100). A limiting mechanism (300) is provided inside the enclosure (200). The limiting mechanism (300) includes multiple sets of limiting rods (310) rotatably connected inside the enclosure (200). The surface of the limiting rods (310) is provided with two intersecting adjusting rods (320).

2. The novel norfloxacin production raw material sample testing device according to claim 1, characterized by, The cross-section of the limiting rod (310) is "L" shaped, and each set of the limiting rods (310) consists of four limiting rods (310) arranged in a "+" shape.

3. The novel norfloxacin production raw material sample testing device according to claim 1, characterized by The inner bottom wall of the enclosure (200) is fixedly connected to a plurality of fixing blocks (340), and the inflection point of the limiting rod (310) is rotatably connected to the fixing blocks (340).

4. The novel norfloxacin production raw material sample testing device according to claim 1, characterized by The surface of the limiting rod (310) has two grooves (311), and a slider (321) is slidably connected inside the groove (311), with the two sliders (321) arranged opposite to each other.

5. The novel norfloxacin production raw material sample testing device according to claim 4, characterized by Two adjusting rods (320) located on the same surface of the limiting rod (310) are provided with a rotating roller (330) at one end away from the limiting rod (310). One end of the adjusting rod (320) is hinged to the inner wall of the slider (321) and the other end is hinged to the rotating roller (330).

6. The novel norfloxacin production raw material sample testing device according to claim 4, characterized by The top of the slider (321) is fixedly connected to a slide rod (322), which is inserted into the inner wall of the limiting rod (310) and slidably connected to the inner wall of the limiting rod (310).

7. The novel norfloxacin production raw material sample testing device according to claim 6, characterized by A spring (323) is sleeved around the slide bar (322), and the spring (323) is fixedly connected between the inner wall of the limiting rod (310) and the slider (321).

8. The novel norfloxacin production raw material sample testing device according to claim 1, characterized by The top end of the limiting rod (310) is rotatably connected to the limiting roller (312), and the surface of the limiting roller (312) has two annular grooves.

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