A signal acquisition system for an adaptive thin film electrode patch for cardiac disease

Abstract

The utility model discloses a kind of signal acquisition systems of self-adaptive film electrode patch for heart disease, it is related to medical instrument technical field, the signal acquisition system includes flexible substrate, nano electrode line, electrode patch and circuit module;The bottom surface of the flexible substrate is provided with adhesive layer, and there are antiallergic drugs in adhesive layer, and the flexible substrate is used for being attached on skin surface by adhesive layer;Multiple nano electrode lines are distributed in the adhesive layer of flexible substrate, and one end of multiple nano electrode lines is respectively arranged in detection point, and the other end of multiple electrode lines is connected with circuit module, and circuit module is used for outputting the electrical signal that electrode patch gathers;The electrode patch includes flexible conductive base layer and contact layer, one side of the flexible conductive base layer is provided with printed circuit, the contact layer is attached on printed circuit, the other side of flexible conductive base layer is used for being bonded on flexible substrate and located in detection point, and flexible conductive base layer is conducted with nano electrode line;The acquisition system is simple to operate, and solve existing lead wire easy to entangle, affect surgical field of vision and patch cause skin allergy and other problems;It has higher use value and popularization value.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a signal acquisition system for an adaptive thin-film electrode patch for heart disease. Background Technology

[0002] In the field of traditional 12-lead electrocardiogram (ECG) testing, this test requires the precise fixation of 10 electrodes distributed in key areas such as the limbs and chest on the patient's body surface. This not only demands professional knowledge and skilled expertise from medical staff to ensure accurate electrode placement, but the entire process is also time-consuming. In confined and urgent settings such as emergency rooms or operating rooms, the numerous leads connected to the electrodes are prone to tangling. This tangling not only increases the difficulty of operation for medical staff but also significantly prolongs the testing time, potentially delaying the patient's diagnosis and treatment. During surgery, the leads can also interfere with the doctor's field of vision, affecting the accuracy and safety of the procedure. Furthermore, unstable electrode-lead connections can easily lead to electrode separation when the patient moves or is slightly touched, causing signal synchronization errors and consequently affecting the accuracy of the ECG diagnostic results.

[0003] The materials and fit of electrode patches are equally important considerations. Most electrode patches on the market use rigid base materials such as polyimide, which, while offering some stability and durability, cannot adapt to the dynamic deformation of the skin during daily activities. Skin is highly flexible and elastic, deforming with breathing and movement. Rigid base electrode patches lack sufficient flexibility to adhere tightly to the skin, easily creating gaps when the skin deforms, leading to unstable signal acquisition. Furthermore, patients vary greatly in body shape; traditional electrode patches are difficult to fit obese patients or those with specific body shapes, and long-term wear can lead to displacement. Electrode patch displacement disrupts signal acquisition stability, distorting the acquired ECG signals and severely impacting the reliability of ECG diagnosis, failing to provide doctors with accurate and effective diagnostic information.

[0004] In addition, the adhesives used in traditional electrode patches contain chemical components that may cause allergic reactions. Children, the elderly, and patients with allergies are at higher risk of developing contact dermatitis after using them. This not only increases patient suffering but may also affect patient cooperation with testing, or even lead to refusal of testing, thereby affecting disease diagnosis and treatment. It may also cause complications such as infection, endangering the patient's health. Utility Model Content

[0005] To address the problems existing in the prior art, this utility model provides a signal acquisition system for an adaptive thin-film electrode patch for heart disease. This acquisition system is simple to operate and solves problems such as easy tangling of existing lead wires, obstruction of the surgical field of vision, and skin allergies caused by the patch.

[0006] This utility model is achieved through the following technical solution: A signal acquisition system for an adaptive thin-film electrode patch for cardiac diseases includes a flexible substrate, nanoelectrode wires, an electrode patch, and a circuit module. The bottom surface of the flexible substrate is provided with an adhesive layer, in which anti-allergy drugs are distributed. The flexible substrate is used to adhere to the skin surface through the adhesive layer. Multiple nanoelectrode wires are distributed on the adhesive layer of the flexible substrate. One end of each nanoelectrode wire is set at a detection point, and the other end of each nanoelectrode wire is connected to a circuit module. The circuit module is used to output the electrical signals collected by the electrode patch. The electrode patch includes a flexible conductive base layer and a contact layer. A printed circuit is provided on one side of the flexible conductive base layer, and the contact layer is attached to the printed circuit. The other side of the flexible conductive base layer is used to adhere to the flexible substrate and is located at the detection point. The flexible conductive base layer is conductive to the nanoelectrode wire.

[0007] Preferably, the adhesive layer is a biocompatible adhesive formed on the surface of a flexible substrate, in which an anti-allergy drug is uniformly dispersed.

[0008] Preferably, the anti-allergy drug is a sustained-release anti-allergy drug or a nano-microneedle anti-allergy drug.

[0009] Preferably, the flexible substrate includes a hub base and multiple flexible arms. One end of each flexible arm is connected to the hub base, and the other end extends to a target location. Each flexible arm is provided with at least one nanoelectrode wire. One end of the nanoelectrode wire is used to connect to an electrode patch, and the other end is located on the hub base.

[0010] Preferably, the flexible support arm has a continuous S-shaped structure, and the nanoelectrode wires are arranged in an S-shape at the center of the flexible support arm.

[0011] Preferably, the surface of the flexible substrate is provided with a protective layer, and the protective layer is provided with a mark, which is set at the detection point.

[0012] Preferably, an insulating layer is formed on the nanoelectrode wire.

[0013] Preferably, the flexible conductive substrate is a copper foil, and a printed circuit is formed on the copper foil. An array of lead electrodes is formed on the printed circuit for collecting electrocardiogram signals.

[0014] Preferably, the contact layer is an adhesive hydrogel layer that is attached to the printed circuit.

[0015] Preferably, the circuit module is fixed on a flexible substrate, and the circuit module is connected to the control terminal in a wired or wireless manner.

[0016] Compared with the prior art, the present invention has the following beneficial technical effects: This application discloses a signal acquisition system for an adaptive thin-film electrode patch for cardiac diseases, integrating the electrode patch and electrode leads into one unit, which is simple to operate and saves time. The flexible layer of the ECG patch is made of a flexible and elastic material, offering multiple size options and adjustable length to accommodate patients of different body types, ensuring the accuracy of ECG signal acquisition. An optional wireless ECG transmitter can be added to achieve wireless transmission of ECG signals, avoiding lead wire tangling and improving operational flexibility. The system is made of flexible material, is thin, breathable, and conforms well to the skin, providing high patient comfort. The adhesive layer contains a sustained-release anti-allergy medication, effectively preventing contact dermatitis caused by prolonged application. Furthermore, a thin, breathable, and anti-allergy transparent flexible base material with ventilation holes ensures system stability while preventing local skin stuffiness. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a structural diagram of the signal acquisition system for the adaptive thin-film electrode patch for heart disease according to this utility model; Figure 2 This is a schematic diagram showing the connection between the signal acquisition system and the control terminal of this utility model.

[0019] In the diagram: 1. Flexible substrate; 2. Nanoelectrode wires; 3. Electrode patch; 4. Circuit module; 5. Control terminal. Detailed Implementation To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0020] Therefore, the following detailed description of the embodiments of this application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely to illustrate selected embodiments of the application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0021] See Figure 1 A signal acquisition system for an adaptive thin-film electrode patch for heart disease includes a flexible substrate 1, nanoelectrode wires 2, an electrode patch 3, and a circuit module 4.

[0022] The bottom surface of the flexible substrate is provided with an adhesive layer, in which anti-allergy drugs are distributed. The flexible substrate is adhered to the skin surface through the adhesive layer. Multiple nanoelectrode wires are distributed on the adhesive layer of the flexible substrate. One end of each nanoelectrode wire is set at a detection point, and the other end of each nanoelectrode wire is connected to a circuit module. The circuit module is used to output the electrical signals collected by the electrode patch. The electrode patch includes a flexible conductive base layer and a contact layer. A printed circuit is provided on one side of the flexible conductive base layer, and the contact layer is attached to the printed circuit. The other side of the flexible conductive base layer is used to adhere to the flexible substrate and is located at the detection point. The flexible conductive base layer is conductive to the nanoelectrode wire.

[0023] In some embodiments, the flexible substrate is a transparent flexible film, and the adhesive layer is a biocompatible adhesive formed on the surface of the flexible substrate (the side in contact with the skin), in which anti-allergy drug components are uniformly dispersed to solve the problem of skin allergies caused by long-term adhesion of the flexible substrate.

[0024] The flexible substrate uses a thin, breathable, hypoallergenic transparent flexible substrate material, such as medical-grade polyimide (PI) or polyurethane (PU) film. The flexible substrate fits the human skin and is highly comfortable. Furthermore, a biocompatible adhesive is coated on the adhesive side of the flexible substrate, and the anti-hypoallergenic drug is uniformly dispersed in the adhesive.

[0025] For example, the flexible substrate has a thickness of 50-100 μm and an elongation of ≥300% to provide mechanical support, adapt to dynamic skin deformation, and an oxygen permeability >5000 g / m². 2 24 hours a day to prevent skin from feeling stuffy and hot.

[0026] Optionally, the adhesive is a medical-grade pressure-sensitive adhesive (such as silicone gel or acrylic adhesive), which has high adhesion, breathability, and no residue properties, ensuring that the electrode adheres firmly to the skin and is easy to peel off.

[0027] Optionally, the anti-allergy medication can be a sustained-release anti-allergy medication, such as hydrocortisone microcapsules or loratadine nanoparticles; alternatively, a nano-microneedle anti-allergy medication layer can be used instead of the anti-allergy medication, which can continuously release the medication during the application process and inhibit skin inflammation.

[0028] In some implementations, the flexible substrate includes a hub base and multiple flexible arms. One end of each flexible arm is connected to the hub base, and the other end extends to a target location. Each flexible arm is provided with at least one nanoelectrode wire, one end of which is used to connect to an electrode patch, and the other end is located on the hub base.

[0029] The target location is the monitoring point for a human electrocardiogram, which consists of multiple flexible arms extending in different directions towards the monitoring point.

[0030] When there is only one target location on the extended roadbed of a flexible support arm, a corresponding nanoelectrode wire is installed on the flexible support arm.

[0031] When there are multiple target locations on the extended roadbed of a flexible support arm, multiple nanoelectrode lines are correspondingly installed on the flexible support arm, and the multiple nanoelectrode lines are arranged at equal intervals on the flexible support arm.

[0032] The flexible support arm has a continuous S-shaped structure, and the nanoelectrode wires are also arranged in an S-shape at the center of the flexible support arm.

[0033] The flexible arm adopts an S-shaped structure, which can adaptively adjust the position of the electrode patch according to the individual differences of the patient. The S-shaped structure of the flexible arm can be used to stretch the flexible arm to extend its length and fix the electrode patch at the target position for different patients.

[0034] It should be noted that individual differences refer to differences in patients' height and weight, mainly height differences. For example, patients with significant height differences will have significantly different positions of the ECG monitoring points. Although the flexible substrate has certain tensile properties, it can only adjust the position of the electrode patch within a small range. Therefore, it cannot solve the problem of electrode patch position adjustment in cases of significant individual differences.

[0035] For situations with significant positional differences, this application designs the flexible support arm as a continuous S-shaped structure, which can also be understood as a wave shape. By stretching the flexible support arm, the S-shaped structure can be extended, allowing for a wide range of adjustment of the electrode pad positions. Furthermore, this S-shaped structure not only adjusts the length of the flexible support arm but also the extension path of the flexible support. For example, multiple electrode pads are installed on the flexible support arm, spaced apart. By adjusting the shape of the S-shaped structure, the position of each electrode pad can be adjusted in multiple directions, making the signal acquisition system suitable for different groups of people.

[0036] See Figure 1The figure includes a hub base and five flexible arms. One end of each of the five flexible arms is connected to the hub base. The other ends of two of the flexible arms extend upwards from the flexible base and are distributed in a figure-eight shape. Two of the flexible arms extend upwards from the flexible base and are distributed in a figure-eight shape. The other flexible arm extends to the right side of the flexible base, and multiple electrode pads are provided on the right flexible arm.

[0037] An electrode patch is provided on each flexible arm above and below the hub substrate, located at the end of the flexible arm.

[0038] In some embodiments, a protective layer is provided on the surface of the flexible substrate (the side that does not contact the skin). The protective layer is a protective film provided on the flexible substrate. The protective film is a medical-grade polyethylene terephthalate (PET) film. The film has moisture-proof and scratch-proof properties. Markings can also be printed on the surface of the film. For example, lead markings (such as V1-V6) can be printed on each detection point. The thickness of the protective layer is 25 μm.

[0039] In some embodiments, the nanoelectrode wires are made of at least one of silver nanowires and graphene quantum dots.

[0040] Silver nanowires have excellent electrical conductivity, while graphene nanosheets enhance the mechanical properties and electrical stability of the material. The synergistic effect of the two ensures that the flexible conductive substrate has excellent flexibility while maintaining stable electrical signal transmission.

[0041] The nanoelectrode wires are arranged in a serpentine manner on a flexible substrate to improve their tensile strength. During the stretching process, the nanoelectrode wires deform while maintaining good conductivity.

[0042] The nanoelectrode wires are formed on a flexible substrate using inkjet printing or screen printing processes. AgNWs ink is deposited into serpentine nanoelectrode wires. The silver nanowires (AgNWs, 30 nm in diameter, density 10⁻⁶) are used. 6 / cm 2 The serpentine design enhances stretchability, achieving an elongation rate of up to 150%.

[0043] Optionally, an insulating layer is formed on the nanoelectrode wire. The insulating layer is a photocurable polyurethane (UV-PU) to isolate the nanoelectrode wire from the external environment, prevent signal crosstalk, and at the same time create local ventilation.

[0044] The thickness of the flexible base layer is controlled between 0.2 and 0.5 mm, ensuring sufficient flexibility to adapt to the complex shape of the heart surface while maintaining good electrical conductivity. The polymer film material can be thermoplastic polyurethane (TPU) film, which has pores, good elasticity, abrasion resistance, and chemical resistance, while also possessing a certain degree of breathability and moisture permeability.

[0045] In some embodiments, the electrode patch includes a flexible conductive base layer and a contact layer. The flexible conductive base layer is a copper foil, and a printed circuit is formed on the copper foil. An array of lead electrodes is formed on the printed circuit for acquiring electrocardiogram signals.

[0046] Optionally, the contact layer is an adhesive hydrogel layer that is attached to the printed circuit. The biocompatible hydrogel layer (0.5 mm thick) contains a microfluidic structure and can release / absorb sweat with skin deformation, exhibiting good conductivity.

[0047] The electrode patch and the flexible substrate can be independently packaged before use. That is, during testing, the electrode patch is attached to the detection point of the flexible substrate and connected to the nanoelectrode wire.

[0048] For example, protective films are attached to both sides of the electrode patch. When in use, the protective films are removed, and the electrode patch is attached to the detection point on the flexible substrate, while ensuring that the copper foil and the nanoelectrode wire are in contact and electrically conductive.

[0049] The electrode patch has a lead of a certain length. One end of the lead is connected to the electrode patch, and the other end is connected to the nanoelectrode wire. The position of the electrode patch can be adjusted through the lead.

[0050] In some embodiments, the circuit module is fixed on a flexible substrate and includes a low-noise instrumentation amplifier (INA333, gain 1000x) and a dynamic impedance detection circuit (frequency 100kHz, resolution 0.1Ω), a multiplexer (ADG732, switching time <1μs); multiple nanoelectrode lines are connected to the circuit module, and the circuit module is connected to the control terminal 5.

[0051] Optionally, the circuit module is connected to the control terminal via wired or wireless means, and the control terminal is used to analyze the patient's cardiac status based on the electrocardiogram signal.

[0052] The wired connection method involves connecting the input end of the circuit module to the nanoelectrode wire, and connecting the output end of the circuit module to the control terminal via a transmission line.

[0053] For example, all the nanoelectrode wires and the connection ends of the circuit module are arranged in parallel and spaced apart to form a connection end. This connection end is inserted into the interface of the circuit module to realize the connection between the circuit module and all the detection point electrode patches. The other end of the circuit module is connected to the control terminal through a wire. The control terminal is an electrocardiogram analyzer.

[0054] The wireless connection method is that the output end of the circuit module is connected to a wireless transmitter and a control terminal.

[0055] See Figure 2The wireless transmitter is a Bluetooth or / and Wi-Fi transmitter, and the circuit module sends the collected electrocardiogram signals to the control terminal through the wireless transmitter.

[0056] Optionally, the control terminal is an electrocardiograph (ECG) machine.

[0057] Example 1 A method of using a signal acquisition system for an adaptive thin-film electrode patch for cardiac disease includes the following steps: Step 1: Use the matching conductive gel (containing 0.9% NaCl + 2% polyvinyl alcohol) to wipe the application area with a non-woven cloth; for hairy areas, use a disposable electric shaver to treat until the skin is bare.

[0058] Step 2: Determine the attachment position of the electrode patch.

[0059] The patient is placed in a supine position. The following key points are located: The ECG electrode patches include four limb lead patches and six chest lead patches, corresponding to the limb leads and chest leads of a standard ECG, respectively. The lead names are marked on the surface (corresponding to the four limb positions: left upper limb LA, right upper limb RA, left lower limb LL, right lower limb RL and chest leads: V1-V6).

[0060] V1: 4th intercostal space at the right sternal border; V2: 4th intercostal space at the left sternal border; LA / RA: 2cm lateral to the midpoint of the left and right clavicles; LL: 5cm above the left anterior superior iliac spine (left lower abdomen); The center of the patch should be aligned with the midpoint of the line connecting V1 and V2, and the edge lead band should extend to the limb positioning point.

[0061] Step 3: Remove the protective film and attach the electrode sticker to the attachment position.

[0062] Peel off the lower protective film (50μm thick polyethylene film). The flexible base layer is circular and made of a thin, breathable, hypoallergenic flexible material. An adhesive layer, 0.1-0.3mm thick, made of silicone gel pressure-sensitive adhesive, is coated on the back of the flexible base layer and contains uniformly dispersed anti-allergy medication (such as hydrocortisone microcapsules). A peelable protective film (not shown) covers the surface of the adhesive layer. Remove the protective film to expose the hydrogel adhesive layer, and press the entire piece onto the patient's skin.

[0063] During the application process, a "center-edge" application method is used: a. First, press the V1-V2 area (for 5 seconds, with a pressure of ≥3kPa). b. Extend the edge lead band along the ribs to ensure that the LA / RA / LL electrodes are in full contact with the skin.

[0064] The anti-allergy medication (such as hydrocortisone microcapsules) in the adhesive layer slowly breaks down under body temperature, releasing the medication to the skin surface, inhibiting histamine secretion, and reducing the risk of allergies; the drug release rate is designed to be sustained for 1-7 days; drug safety: the addition of allergy medication meets medical standards (such as FDA or CE certification), and the concentration is controlled within a safe range (e.g., hydrocortisone content ≤1%).

[0065] Step 4: Connect the output of the circuit module to the control terminal via a transmission line.

[0066] In this embodiment, the flexible electrode interface (3.5mm in diameter, conforming to IEC 60601-1 standard) is connected to the input terminal of the circuit module, and the output terminal of the circuit module is connected to the electrocardiogram analyzer through the electrocardiogram signal transmission line to transmit the electrocardiogram signal to the electrocardiogram analyzer for analysis. During the operation, the electrode patch collects the tissue impedance in real time and outputs the generated electrocardiogram signal to the display device of the electrocardiogram analyzer.

[0067] This circuit module can also connect to an electrocardiogram analyzer via Bluetooth for continuous patient monitoring.

[0068] Correspondingly, this application also provides a method for analyzing electrocardiogram signals, including the following steps: Step 1: Obtain electrocardiogram (ECG) signals; Step 2: Filter and reduce noise in the ECG signal to eliminate motion artifacts; Data was acquired using a triaxial accelerometer (LIS2DH12) and input into an improved least mean square (LMS) filter. This filter effectively suppresses interference signals caused by body movement and reduces the impact of motion artifacts on electrocardiogram signals.

[0069] Wavelet decomposition of the electrocardiogram (ECG) signal was performed using the db4 wavelet basis. For the high-frequency noise component, a soft thresholding method was employed for denoising. Soft thresholding can effectively remove noise while preserving key ECG signal features and avoiding signal distortion.

[0070] Step 3: Use morphological filtering to calibrate the baseline of the ECG signal to obtain the baseline-corrected ECG signal.

[0071] The baseline of the electrocardiogram (ECG) signal is extracted using the opening operation method in morphological filtering. The opening operation effectively smooths the signal and removes interference factors such as baseline drift. Subsequently, the extracted baseline is subtracted from the original ECG signal to obtain the baseline-corrected ECG signal, ensuring signal accuracy.

[0072] Step 4: Use the Pan-Tompkins algorithm to detect QRS waves in the electrocardiogram signal obtained in Step 3 to obtain the potential change characteristics of ventricular depolarization.

[0073] First, the ECG signal is subjected to differential and squaring operations to enhance the characteristics of the R wave, making it more prominent in the signal. Then, an adaptive threshold is used to determine the location of the QRS wave. This algorithm has high detection sensitivity (>99%) and specificity (>95%), and can accurately identify the QRS wave.

[0074] Step 5: Using the TP segment of the ECG signal as a baseline, determine the ST segment offset. Based on the slope and amplitude characteristics of the ST segment, classify it into horizontal, downsloping, and upsloping ST segment changes. Different morphologies of ST segment changes correspond to different heart diseases. Accurate classification of ST segment morphology helps diagnose cardiac health status.

[0075] In addition, this application also provides a method for analyzing electrocardiogram signals based on a neural network model, including the following steps: Step 1: Construct a hybrid model of convolutional neural network and bidirectional long short-term memory network; In this embodiment, a hybrid model combining a 5-layer convolutional neural network (CNN, 5×1 kernel) and a bidirectional long short-term memory network (BiLSTM, 128 hidden units) is constructed. CNN can automatically extract local features of ECG signals, while BiLSTM excels at processing sequential data and capturing long-term dependencies in signals. Combining the two can fully leverage their respective advantages and improve diagnostic performance.

[0076] The model was trained using publicly available databases such as MIT-BIH and PTB-XL. To improve the model's generalization ability, the training data was augmented, including adding noise, signal scaling, and shifting, so that the model could adapt to the characteristics of ECG signals under different environments.

[0077] Step 2: Input the preprocessed 12-lead ECG signal into the hybrid model. The signal duration is 10 seconds, and the sampling rate is 500Hz. Abundant lead information and a sufficiently long signal duration provide the model with comprehensive cardiac electrical activity information, which helps in accurate diagnosis.

[0078] Step 3: The hybrid model outputs arrhythmia indicators from the electrocardiogram signal, such as indicators of atrial fibrillation, ventricular tachycardia, and atrioventricular block.

[0079] Step 4: Output alarm signals based on arrhythmia indicators and thresholds, and simultaneously generate a report.

[0080] For example, the criteria for diagnosing ventricular fibrillation / pulseless ventricular tachycardia are: disappearance of QRS waves, frequency >300 bpm, and no pulse signal in PPG; ST-segment elevation myocardial infarction: ST-segment elevation ≥1 mm (male) or ≥1.5 mm (female) in adjacent leads. Automatically generates a PDF report, including waveform screenshots, diagnostic conclusions, and treatment recommendations (such as "urgent coronary angiography recommended"). The above content is only for illustrating the technical concept of this utility model and should not be construed as limiting the scope of protection of this utility model. Any modifications made to the technical solution based on the technical concept proposed in this utility model shall fall within the scope of protection of the claims of this utility model.

Claims

1. A signal acquisition system for an adaptive thin-film electrode patch for heart disease, characterized in that, Includes flexible substrates, nanoelectrode wires, electrode patches, and circuit modules; The bottom surface of the flexible substrate is provided with an adhesive layer, in which anti-allergy drugs are distributed. The flexible substrate is used to adhere to the skin surface through the adhesive layer. Multiple nanoelectrode wires are distributed on the adhesive layer of the flexible substrate. One end of each nanoelectrode wire is set at a detection point, and the other end of each nanoelectrode wire is connected to a circuit module. The circuit module is used to output the electrical signals collected by the electrode patch. The electrode patch includes a flexible conductive base layer and a contact layer. A printed circuit is provided on one side of the flexible conductive base layer, and the contact layer is attached to the printed circuit. The other side of the flexible conductive base layer is used to adhere to the flexible substrate and is located at the detection point. The flexible conductive base layer is conductive to the nanoelectrode wire.

2. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, The adhesive layer is a biocompatible adhesive formed on the surface of a flexible substrate, in which an anti-allergy drug is uniformly dispersed.

3. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, The anti-allergy medication is a sustained-release anti-allergy medication or a nano-microneedle anti-allergy medication.

4. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, The flexible substrate includes a hub base and multiple flexible arms. One end of each flexible arm is connected to the hub base, and the other end extends to the target position. Each flexible arm is provided with at least one nanoelectrode wire. One end of the nanoelectrode wire is used to connect to the electrode patch, and the other end is located on the hub base.

5. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 4, characterized in that, The flexible support arm has a continuous S-shaped structure, and the nanoelectrode wires are arranged in an S-shape at the center of the flexible support arm.

6. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, The surface of the flexible substrate is provided with a protective layer, and the protective layer is provided with markings, which are placed at the detection points.

7. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, An insulating layer is formed on the nanoelectrode wire.

8. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, The flexible conductive substrate is a copper foil, and a printed circuit is formed on the copper foil. An array of lead electrodes is formed on the printed circuit for collecting electrocardiogram signals.

9. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, The contact layer is a viscous hydrogel layer that is attached to the printed circuit.

10. The signal acquisition system for an adaptive thin-film electrode patch for heart disease according to claim 1, characterized in that, The circuit module is fixed on a flexible substrate and is connected to the control terminal via wired or wireless means.

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