Benzpyroxyoxane for the control of mosquitoes and other dipteran insects

Abstract

Methods and compositions for killing larvae of dipteran and hematophagous insects, in particular the larvae of disease-carrying mosquitoes, are provided. The methods may involve contacting dipteran or mosquito larvae with a pesticidal-effective amount of benzopyrimoxane or a salt, solute, hydrate, or solvate thereof. The methods and compositions disclosed herein demonstrate good contact efficacy against mosquito populations that are highly resistant to insecticides, including those resistant to pyrethroids.

Description

ARTThe present disclosure relates generally to methods and compositions for controlling diptera insects, such as mosquitos and house flies, particularly disease-bearing mosquitos and diptera insects. More particularly, the present disclosure relates, among other embodiments, to methods for controlling mosquito populations and / or killing mosquito larvae or pupae comprising contacting one or more mosquito larvae or pupae or a mosquito slide surface or an aqueous mosquito slide environment likely to be infested with mosquito larvae or pupae with a larvicidal composition comprising benzopyrimoxan.BACKGROUNDHematophageal insect species such as mosquitos, rubble mosquitos, sandflies, tsetse flies, ticks, lice, fleas, midges, predances, and triatoinae are the major arthropod vectors of diseases due to their mouth tools and chemical agents to penetrate and feed from the vasculature of the skin of host animals. Hematophage diptera species in particular are considered to be particularly important vectors in both the biological and mechanical transmission of a variety of diseases. Many flies function as mechanical disease vectors by taking infectious agents on the outside of their bodies and transporting the infectious agent to an animal host where they transfer the pathogen to the host by physical contact. In mechanical transmission, insects are contaminated with a virus or other pathogen during normal feeding, and the virus or pathogen is persistent on their mouth tools or body until the next feeding, by which the virus or pathogen is transferred to a new host animal. In contrast, other diptera species, such as mosquitos, function as biological vectors by not only transporting pathogens but also playing a role in the life cycle of the pathogens, allowing the pathogen to proliferate in the insect's body before delivery to a new animal host.Mosquitos can transmit diseases such as malaria transmitted from various mosquitos of the genus Anopheline (such as Anopheles gambiae or Anopheles funestus), or the Zika virus, yellow fever, Dengue fever and Chikungunya transmitted from mosquitos of the genus Aedes (e.g., Aedes aegypti or Aedes albopictus). Approximately 390 million people infect dengue virus each year, at risk of about half of the world's population. In 2017, around 97,400 people infected with yellow fever, although vaccination is available. The Zika virus is widely distributed in tropical and subtropical areas in 86 countries and 2.2 million cases have been reported in 2017. While targeted efforts have been made to combat Aedes aegypti, the major vector of these nonmalarial diseases, including chemical protection measures against adults and larvae, management of larval sources, exposure to sterile populations and the use of wolbachiain-infected mosquitos, the most important methods for combating A. aegypti vectors in Asia continue to rely heavily on the use of larvicides.Insecticide-treated bed nets (ITN) and indoor residual spray (IRS) have been developed with the aim of vector controlling adult disease-bearing mosquitos and have contributed to a decrease in malaria cases by almost about 80% from 2000 to 2015. ITNs and IRSs are both interventions which target mosquitos which sting in interiors and rest in interiors, such as, for example, An. gambiae and An. funestus. However, An. stephensi, an invasive species of the Asian continent, has recently become established in Subsahara Africa (SSA) and now propagates throughout the region. An. stephensi is considered to be an outdoor lancing and outdoor resting mosquito that cannot be efficiently controlled by internal space interventions such as ITN and IRS. Other mosquito deposits, such as Aedes species and Culex species, are also mosquitos which are free-piercing and resting in the open, requiring interventions other than those used in malaria vectors. In particular, the use of larvae is generally recommended to combat outdoor mosquito populations and diseases transmitted by these vectors. Larvicides control mosquito populations by killing mosquito larvae at mosquito breeds, thereby reducing or eradicating adult mosquito populations in the treatment zone.In the past decades, only a limited number of compounds have been available for mosquito control, including organophosphates, carbamates and pyrethroids. Recently, neonicotinoids, butenolides, benzoylureas and juvenile hormone mimetics have also become available. However, in most cases the latter are used together with a pyrethroid. Pyrethroids are the most commonly used insecticidal class of vector control products and in 2022, about 80% of the vector control products certified by the World Health Organization (WHO) contain a pyrethroid. Pyrethroids have three advantages: they have good contact efficiency, they are fast acting, which is important because the mosquito often comes into contact with the compound for only a few seconds, and they have a good toxicological profile over mammals. However, due to the frequent use of pyrethroids, mosquitos have developed resistance to pyrethroids and pyrethroids can no longer reliably provide good protection from disease-transferring mosquitos. In addition, there has also been reported a cross-resistance of pyrethroid-resistant mosquitos to pyriproxyfen, one of the most commonly used larvae.In 2000, there were around 1 million deaths worldwide due to malaria. By more financial means, new campaigns, enhanced vector control, new medical treatments and antimalarial institutions, malaria cases and malaria deaths decreased to 400,000 in 2015. However, malaria deaths increased again to 600,000 in 2021, insecticide resistance and the spread of invasive an. stephensi being essential factors contributing to this trend. A problem with current insecticides used for mosquito vector control is the limited number of chemical classes available for mosquito control, which results in a limited number of pesticidal activities, leading to the rapid development of insecticide resistance in mosquito populations. Thus, Applicant has recognized that novel compositions and methods for killing or controlling mosquitos, particularly insecticide resistant mosquitos, are desirable for controlling malaria and other diseases transmitted by mosquitos.SUMMARYTo address these circumstances, Applicant has developed novel methods and compositions for killing mosquito larvae and for controlling populations of adult mosquitos. In particular, the methods disclosed herein involve the use of compositions containing a pesticidally effective amount of benzpyrimoxane or a salt, solute, hydrate or solvate thereof. The Applicant has surprisingly found that benzopyrimoxan exhibits good larvicidal activity against various mosquito species, including mosquito populations resistant to pesticides such as pyrethroid insecticides (e.g., mosquito populations having a deltamethrin resistance ratio of greater than 50). Surprisingly, mosquito larvae, when exposed to the presently disclosed benzpyrimoxan compositions, often develop through all four larval stages and into the pupae stage, but do not come out of the pupae stage or do not unpunculate to become stinging, disease-bearing adult vectors. Applicant has found that mosquito larvae contacted with compositions comprising higher benzpyrimoxan concentrations are killed without traversing all stages of larvae or are killed while still in the stage of development of a pupa.The present disclosure provides methods for killing mosquito larvae and methods for controlling populations of adult mosquitos by killing mosquito larvae and / or preventing further development of mosquito larvae beyond the stage of development of a pupa or depoping to form an adult mosquito. The methods disclosed herein may include contacting mosquito larvae or a population of mosquito larvae with a pesticidally effective amount of benzpyrimoxane or a salt, solute, hydrate, or solvate thereof. The method may also include treating a mosquito breeding environment with a pesticidally effective amount of benzopyrimoxan or a salt, solute, hydrate or solvate thereof. In other embodiments, treating the mosquito breeding environment, or contacting mosquito larvae or a population of mosquito larvae, may include treating a mosquito breeding environment with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate, or solvate thereof. The method may also include, at least in some embodiments, spraying a liquid larvicide composition into the mosquito breeding environment or onto a surface thereof.In other embodiments, treating a mosquito breeding environment with a larvicidal composition may include depositing or applying a solid larvicidal composition into the mosquito breeding environment or onto a surface of the mosquito breeding environment. In such cases, the solid larvicide composition may be capable of dissolving or dispersing when wet or in contact with water. Non-limiting examples of solid larvicide compositions may include a tablet, pellet, briquettes, granules, wettable granule formulation, or sachet comprising wettable granule formulation.The present disclosure also provides larvicidal compositions capable of killing mosquito larvae or pupae, or otherwise capable of preventing mosquito larvae or pupae from developing or depuncting into an adult mosquito vector. The larvicidal compositions disclosed herein may include a larvicidally effective amount of benzpyrimoxane. In certain embodiments, the larvicidal compositions may be capable of killing at least 90% of mosquito larvae contacted with the larvicidal composition. In other embodiments, the larvicidal compositions may be capable of killing at least 95% of mosquito larvae contacted with the larvicidal composition. In still other embodiments, the larvicidal compositions may be capable of preventing at least 90% of mosquito larvae contacted with the larvicidal composition from depupping or otherwise becoming adult mosquito. The larvicidal compositions may also be capable of preventing at least 95% of the mosquito larvae contacted with the larvicidal composition from depupping or otherwise becoming an adult mosquito.The methods and compositions disclosed herein may be effective in killing or preventing the depopulation of mosquito larvae belonging to any of the types of disease-bearing mosquito. Examples of disease-bearing mosquitos may include, but are not limited to, Anopheles gambiae, Anopheles funestus, Aedes aegypti, Culex quinquefasciatus, Anopheles stephensi, and Aedes albopictus. In addition, the methods and compositions disclosed herein may be effective in killing or preventing the depopulation of insecticide resistant mosquito larvae. Accordingly, the methods and compositions disclosed herein may be effective in controlling populations of adult vector or disease-bearing mosquitos or effective in preventing or attenuating the transmission of one or more mosquito-bearing diseases to a human or animal who / she owns a vector control area in which the method or compositions are applied. In particular, the methods and compositions disclosed herein may be effective for controlling or controlling any mosquito-mediated disease, including, but not limited to, malaria, yellow fever, dengue fever, Zika virus, west nile virus, chikungunya virus, equine eastern encephalitis virus, Japanese encephalitis virus, La cross encephalitis, and St. Louis encephalitis.The present disclosure also provides a mosquito rublet capable of killing mosquito larvae and / or controlling populations of adult mosquitos. The mosquito slide trap may include a reservoir configured to hold or contain water and capable of receiving one or more female mosquitos. The reservoir may be further capable of containing any of the presently disclosed larvicidal compositions comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof. The mosquito rublet may further include a larvicidal benzpyrimoxan composition disposed in or contained within the reservoir of the mosquito rublet. At least in some embodiments, the reservoir may be further capable of receiving and collecting rainwater. The mosquito rubbish may also include a means for attracting one or more female mosquitos.The present disclosure also provides methods for killing larvae of diptera insects or hematophageal insect species, as well as methods for controlling populations of adult diptera. The methods may include contacting larvae of diptera or hematophageal insects or a population of larvae of diptera or hematophageal insects with a pesticidally effective amount of benzopyrimoxan or a salt, solute, hydrate or solvate thereof. In certain embodiments, the methods may include treating a dipterene breeding environment with a pesticidally effective amount of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof. In some cases, the methods may include treating a dipterene breeding environment with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate, or solvate thereof. The methods may also include spraying a liquid larvicide composition into the diptere breeding environment or onto a surface of the diptere breeding environment.In other embodiments, treating a diptere breeding environment with a larvicidal composition may include depositing or applying a solid larvicidal composition into the diptere breeding environment or onto a surface of the diptere breeding environment. In such cases, the solid larvicide composition may be capable of dissolving or dispersing when wet or in contact with water. Non-limiting examples of solid larvicide compositions may include a tablet, pellet, briquettes, granules, wettable granule formulation, or sachet comprising wettable granule formulation.As used herein, the term "diptera rub environment" in all forms thereof refers to any environment that contains or comprises one or more diptera larvae, or any environment or surface where diptera insects can deposit or brute eggs. The diptera rub environment may be a natural environment, such as standing water or naturally deposited rotant organic materials, fecal or larval feed sources, or may be a human created environment, such as a container, insect rubtrap, or other object likely to be used as a diptera rub environment by a breeding diptera insect. Non-limiting examples of diptera breeding environments may include rotable organic material, animal diet, larval feed sources, rinnes, cisterns, livestock water troughs, livestock ponds, waterfields, water storage containers, buckets, rain barrels, fountains, gutters, downcomers, non-chlorinated swimming pools, pool covers in which water collects, tires, tree cavities, open bodies of water, standing bodies of water, silent bodies of water, running bodies of water, small rivers, breds, gulys, and plant vessels or reducers.The present disclosure also provides larvicidal compositions capable of killing the larvae or pupae of diptera insects or hematophageal insect species, mosquito larvae, or otherwise capable of preventing larvae or pupae of diptera or hematophageal insects from developing or deputing to an adult diptera or hematophageal insect vector. The larvicidal compositions disclosed herein may contain a larvicidally effective amount of benzpyrimoxane. In certain embodiments, the larvicidal compositions may be capable of killing at least 90% of larvae of diptera or hematophageal insects contacted with the larvicidal composition. In other embodiments, the larvicidal compositions may be capable of killing at least 95% of larvae of diptera or hematophageal insects contacted with the larvicidal composition. In still other embodiments, the larvicidal compositions may be capable of preventing at least 90% of the diptera or hematophage larvae contacted with the larvicidal composition from depopulating or otherwise forming an adult insect. The larvicidal compositions may also be capable of preventing at least 95% of the diptera or hematophage larvae contacted with the larvicidal composition from depupping or otherwise forming an adult insect.The methods and compositions disclosed herein may be effective in killing or preventing depopulation of larvae belonging to any of the species of disease-bearing diptera or hematophageal insects. Examples of disease-bearing diptera or hematophageal insects may include, but are not limited to, mosquitos, rubble mosquitos, houseflies, sandflies, tsetseflies, chrysopsflies (hirschl flies / goldflies), ticks, lice, fleas, midges, predances, and triatoniae. In addition, the methods and compositions disclosed herein may be effective in killing or preventing depopulation of diptera or hematophage larvae that are insecticidally resistant. Accordingly, the methods and compositions disclosed herein may be effective for controlling populations of adult vector or disease-bearing diptera or hematophageal insects, or effective for preventing or attenuating the transmission of one or more diseases transmitted by diptera or hematophageal insects to a human or animal who owns a vector control area in which the method or compositions are applied.The present disclosure also provides a breeder trap for diptera or hematophage insects that is capable of killing larvae of diptera or hematophage insects and / or controlling populations of adult diptera or hematophage insects. The breeder trap for diptera or hematophageal insects may comprise a breeder compartment configured to receive one or more breeder diptera or hematophageal insects. The gross compartment is further capable of incorporating any of the presently disclosed larvicidal compositions comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof. In certain embodiments, the broadleaf trap for diptera or hematophageal insects may comprise or contain the larvicidal composition as well as an agent for attracting one or more firefly diptera or hematophageal insects.Still other aspects and advantages of these example embodiments and other embodiments are discussed in detail herein. Moreover, it is to be understood that both the foregoing information and the following detailed description are intended to provide merely illustrative examples of various aspects and embodiments and provide an overview or framework for understanding the nature and character of the claimed aspects and embodiments. Accordingly, these and other advantages and features of the present disclosure will become apparent with reference to the following description and the accompanying drawings. In addition, it should be understood that the features of the various embodiments described herein are not mutually exclusive and may be present in various combinations and permutations.BRIEF DESCRIPTION OF THE DRAWINGSThe accompanying drawings, which are included to provide a further understanding of the embodiments of the present disclosure, are incorporated in and constitute a part of this specification, illustrate embodiments of the present disclosure, and together with the detailed description, serve to explain the principles of the embodiments discussed herein. It is not intended to show structural details of this disclosure in greater detail than is necessary for a basic understanding of the embodiments discussed herein and the various ways in which they may be practiced. In accordance with common practice, the various features of the drawings discussed below are not necessarily to scale. The dimensions of various features and elements in the drawings may be increased or decreased to more clearly illustrate embodiments of the disclosure. FIG. 1 is a graph of the mean slip rate (from pupa to adult) of Aedes aegypti mosquito larvae 14 days after treatment with a benzpyrimoxan composition according to an exemplary embodiment of the present disclosure. FIG. 2 is a graph of the mean slip rate (from pupa to adult) of Anopheles stephensi larvae 14 days after treatment with a benzpyrimoxane composition according to an exemplary embodiment of the present disclosure. FIG. 3 is a graph of mean mortality of susceptible and resistant Aedes aegypti larvae over time in days after treatment with a 10 ppm benzpyrimoxane composition according to an exemplary embodiment of the present disclosure. FIG. 4 is a graph of mean mortality of Anopheles stephensi larvae over time in days after treatment with a 1 ppm or 10 ppm of benzpyrimoxane composition according to an exemplary embodiment of the present disclosure.DETAILED DESCRIPTIONThe present disclosure describes various embodiments that describe methods and compositions for controlling mosquito populations as well as for preventing or attenuating human and animal disease exposure in vector control areas resulting from mosquito transfer. Other embodiments may be described and disclosed.In the following description, numerous details are set forth in order to provide a thorough understanding of the various embodiments. In other instances, well-known processes, devices, and systems may not be described in particular detail in order not to unnecessarily obscure the various embodiments. In addition, certain features or details may be omitted from illustrations of the various embodiments in order not to obscure the various embodiments.In the specification, the terms "in some embodiments," "in various embodiments," "in one embodiment," or "in embodiments" may have been used, which may each refer to one or more same or different embodiments. Furthermore, the terms "comprising", "including", "having" and the like as used in relation to embodiments of the present disclosure are synonymous.The terms "about" or "about" are to be understood in the vicinity of what is understood by one of ordinary skill in the art. In a non-limiting embodiment, the terms are to be understood as within 10%, preferably within 5%, more preferably within 1% and most preferably within 0.5%.The terms "reduce", "reduced", or any variation thereof, when used in the claims and / or specification, include any measurable reduction or complete inhibition to achieve a desired result.The words "a" or "an" when used in connection with any of the terms "comprising", "including", "containing" or "having" in the claims or the description mean "one", but also conform to the meaning "one or more", "at least one" and "one or more than one". The terms "wt %, "vol %" or "mol %" refer to a weight, volume and mol percentage, respectively, of a component based on the total weight, the total volume of the material, or the total amount of moles that the component contains. In a non-limiting example, 10 g of the component in 100 g of the material is 10 wt % of the component.The words "comprising" (and any form of comprising, such as "comprising" and "comprising"), "having" (and any form of comprising, such as "comprising" and "having"), "including" (and any form of including, such as "including" and "including") or "containing" (and any form of containing, such as "containing" and "containing") are inclusive or open and do not exclude additional, non-listed elements or method steps.When ranges are disclosed herein, they may be both ranges of any lower limit combined with any upper limit to indicate a range not explicitly recited, and ranges of any lower limit combined with any other lower limit to indicate a range not explicitly recited, and ranges of any upper limit combined with any other upper limit to indicate a range not explicitly recited. Moreover, reference to values indicated in ranges includes any single value within that range, although not explicitly stated. Thus, each point or singular value may serve as its own lower or upper limit, combined with any other point or singular value or lower or upper limit, to indicate a range not explicitly stated.The present disclosure provides methods and compositions for killing larvae of diptera and / or hematophageal insects, as well as for controlling populations of adult diptera and hematophageal insects. The methods and compositions disclosed herein may be particularly useful for killing mosquito larvae, thereby controlling populations of adult mosquitos and reducing the transmission of diseases carried and transmitted by adult mosquito vectors. The compositions and methods disclosed herein involve the use of a pesticidally effective amount of benzpyrimoxan or a salt, solute, hydrate or solvate thereof which has surprisingly been found to exhibit good larvicidal activity against diptera insects, including various mosquito species. The compositions and methods disclosed herein have also been found to be effective in killing insect larvae belonging to insect populations resistant to one or more pesticides. For example, the compositions and methods disclosed herein have been found to be effective against mosquito larvae populations resistant to pesticides such as pyrethroid insecticides (e.g., mosquito populations exhibiting a deltamethrin resistance ratio of greater than 50).According to one aspect of the present disclosure, a larvicidal composition is provided. As used herein, the term "larvicidal composition" in all its forms refers to a composition capable of killing insect larvae or pupae or capable of preventing insect larvae or pupae from developing into an adult insect. The larvicidal compositions provided herein contain a pesticidally effective or larvicidally effective amount of benzopyrimoxane or a salt, solute, hydrate or solvate thereof. Benzopyrimoxane, also known as 5-(1,3-dioxan-2-yl)-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrimidine, may have the following chemical structure: As used herein, the term benzpyrimoxan, in all its forms, refers to any salt, solute, hydrate or solvate of benzpyrimoxan, or the compound of Structure I. The presently disclosed larvicidal compositions may include any pesticidally or larvicidally effective amount of benzpyrimoxan, depending upon its particular intended use or formulation. The larvicidal compositions may include, for example, from about 0.05% to about 65% by weight of benzpyrimoxane, or from about 1% to about 25% by weight of benzpyrimoxane, or from about 2% to about 15% by weight of benzpyrimoxane, or from about 5% to about 15% by weight of benzpyrimoxane. At least in some cases, the larvicidal compositions may comprise less than 10% by weight of benzpyrimoxane, or less than 15% by weight of benzpyrimoxane, or less than 5% by weight of benzpyrimoxane.In addition to benzpyrimoxan, the larvicidal compositions disclosed herein may include any adjuvant or chemical component necessary to prepare the disclosed formulations or necessary to perform the methods disclosed herein. For example, the larvicidal compositions may include an agent selected from the group consisting of an adjuvant, a wetting agent, a dispersant, an emulsifier, a penetrating agent, a preservative, an antifreeze agent and an evaporation inhibitor. In certain embodiments, the larvicide compositions may include one or more other larvicides in addition to benzpyrimoxane. Examples of other larvae which may be used in the larvae of the present compositions include methoprene, S-methoprene, S-kinoprene, S-hydropen and temephos. In certain embodiments, the larvicidal compositions may also include Bacillus thuringiensisisraelensisand / or Bacillus sphaericus. The larvicidal compositions may also include one or more mineral oils and / or monomolecular films. In certain embodiments, the larvicide compositions may also include one or more other larvicides from the benzylurea family. For example, the larvicidal compositions may include 2,6-difluorobenzylurea.In other embodiments, the larvicide compositions may exclude or otherwise not contain another larvicide. The larvicidal compositions may be substantially free of an insecticide or larvicide other than benzpyrimoxane. For example, the larvicide compositions may exclude or otherwise not contain a larvicide from the benzylurea family or another larvicide selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen, temephos, Bacillus thuringiensis israelensisand Bacillus sphaericus.The larvicidal compositions may be in the form of any formulation required to carry out the methods disclosed herein. For example, the larvicidal compositions may be in the form of any formulation selected from an emulsifiable concentrate (EK), an emulsion-in-water (EW), a suspension concentrate (SK), a suspoemulsion (SE), a flowable concentrate (FK), a wettable powder (BP), a soluble liquid concentrate (LF), a soluble powder (LP), an ultra-low-volume spray (ULV), and any combination thereof.In certain embodiments, the larvicidal composition may be in the form of a liquid formulation. The liquid formulation may be a liquid larvicidal composition suitable for spraying into an environment containing an insect larvae population, into an insect breeding environment, or onto a surface likely to contact one or more insect larvae. In certain embodiments, the liquid larvicide composition may be suitable for spraying using a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer. The liquid larvicide composition may include water and / or one or more solvents. At least in some cases, the liquid larvicide composition may include water and one or more organic solvents such as acetone, ethanol, propylene glycol monomethyl ether, tetrahydrofurfuryl alcohol, dipropylene glycol, isopropanol, acetonitrile, propionitrile, polar aprotic solvents, N,N-dimethylformamide or N-methylpyrrolidone.In certain embodiments, the larvicidal composition may be in the form of a liquid formulation suitable for dilution with water prior to application to an insect larvae population, environment of breeding insects, or surface likely to contact one or more insect larvae. In such embodiments, the larvicidal composition may be a liquid concentrated larvicidal composition.In other embodiments, the larvicidal composition may be a solid larvicidal composition capable of dissolving or dispersing when wet or in contact with water. In such embodiments, the solid larvicide composition may be in the form of a tablet, pellet, briquettes, granules, wettable granule formulation, pouch comprising wettable granule formulation, or any combination thereof.The larvicidal compositions may be capable of killing larvae of diptera or hematophageal insects, or may be capable of preventing the development of larvae or pupae of diptera or hematophageal insects into an adult diptera or hematophageal insect. Examples of insect larvae against which the larvicide compositions disclosed herein may be effective include mosquitos, rubble mosquitos, houseflies, sandflies, tsetse flies, chrysopsflies (hirschus flies / goldflies), ticks, lice, fleas, midges, raub bugs, triatoinae, and any combination thereof. In addition, the larvicide compositions may be effective in killing larvae resistant to one or more insecticides. For example, the larvicide compositions may be effective against larvae resistant to pyrethroids, DDT, carbamates, and / or organophosphates.In certain embodiments, the larvicidal compositions may be capable of killing at least 90% of larvae contacted with the larvicidal composition. In other embodiments, the larvicidal compositions may be capable of killing at least 95% of larvae contacted with the larvicidal composition. In still other embodiments, the larvicidal compositions may be capable of preventing at least 90% of larvae contacted with the larvicidal composition from decapping or otherwise forming an adult insect. In other embodiments, the larvicidal composition may be capable of preventing at least 95% of larvae contacted with the larvicidal composition from depupping or otherwise forming an adult insect.The larvicidal compositions disclosed herein can be particularly effective against mosquito larvae, including mosquito larvae classified as being free biting and free resting mosquitos. In certain embodiments, the larvicidal compositions may be effective to kill larvae belonging to the genus Anopheles, Culex, or Aedes. The larvicidal compositions may also be effective to kill larvae selected from the group consisting of Anopheles gambiae, Anopheles funestus, Aedes aegypti, Culex quinquefasciatus, Anopheles stephensi and Aedes albopictus. In certain embodiments, the mosquito larvae may be resistant to one or more insecticides. The one or more insecticides may be selected from the group consisting of pyrethroids, DDT, carbamates, and organophosphates, for example.The present disclosure also provides methods for killing the larvae of diptera insects or hematophageal insect species, as well as methods for controlling adult diptera populations. The methods may include contacting larvae of diptera or hematophage insects or a population of larvae of diptera or hematophage insects with a pesticidally effective amount of benzpyrimoxan or a salt, solute, hydrate or solvate thereof. In certain embodiments, the methods may include applying a pesticidally effective amount of benzopyrimoxan, or a salt, solute, hydrate, or solvate thereof, to an insect larvae population, environment of insect breeding, or surface likely to contact one or more insect larvae. In some cases, the methods may include treating an insect larvae population, environment of insect breeding, or surface likely to contact one or more insect larvae with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.At least in some embodiments, the methods may include treating or spraying an insect larvae population, environment of insect breeding, or surface likely to contact one or more insect larvae with a liquid larvicidal composition, such as any of the liquid larvicidal compositions disclosed herein. In certain cases, the liquid larvicide compositions may be sprayed or applied using a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.In other embodiments, treating an insect larvae population, environment of insect breeding, or surface likely to contact one or more insect larvae may include depositing or applying a solid larvicide composition into the breeding environment or to the surface likely to contact one or more insect larvae. In such cases, the solid larvicide composition may be capable of dissolving or dispersing when wet or in contact with water. Non-limiting examples of solid larvicide compositions may include a tablet, pellet, briquettes, granules, wettable granule formulation, or sachet comprising wettable granule formulation.As used herein, the term "breeding environment" in all forms thereof refers to any environment that contains or encompasses one or more larvae of diptera or hematophageal insects, or any environment or surface where diptera or hematophageal insects can deposit or breed eggs. The breeding environment may be a natural environment such as a standing water or a feed source for insect larvae, or may be a man-made environment such as a container, insect slide trap, or other object that is expected to be used as breeding environment by a dipteran insect.In certain embodiments, the incubation environment may be a breeder trap for diptera or hematophageal insects. In such cases, the method may further include introducing a larvicidal composition comprising benzopyrimoxan into the reservoir of a breeder trap for diptera or hematophageal insects. The methods may also include causing a larvicidal composition comprising benzopyrimoxan to be placed in a reservoir of a breeder trap for diptera or hematophageal insects. The method may also include loading a larvicidal composition comprising benzpyrimoxan into a reservoir of a breeder trap for diptera or hematophageal insects.The methods disclosed herein may comprise applying benzpyrimoxan or a larvicidal composition containing benzpyrimoxan to a breeding environment of diptera or hematophageal insects at an application rate of from about 1 gram (g) of active ingredient to about 1000 g of active ingredient per hectare (ha). In certain embodiments, the methods may include applying benzpyrimoxan or a larvicidal composition containing benzpyrimoxan, In an application rate of from about 1 g active ingredient / ha to about 750 g active ingredient / ha, or from about 1 g active ingredient / ha to about 500 g active ingredient / ha, or from about 1 g active ingredient / ha to about 250 g active ingredient / ha, or from about 1 g active ingredient / ha to about 150 g active ingredient / ha, or from about 25 g active ingredient / ha to about 150 g active ingredient / ha, or from about 5 g active ingredient / ha to about 250 g active ingredient / ha, or from about 50 g active ingredient / ha to about 500 g active ingredient / ha, or from about 150 g active ingredient / ha to about 350 g active ingredient / ha, or from about 250 g active ingredient / ha to about 750 g active ingredient / ha, or from about 500 g active ingredient / ha to about 750 g active ingredient / ha, or from about 500 g active ingredient / ha to about 1000 g active ingredient / ha. The methods disclosed herein may also include applying a larvicidal composition comprising benzpyrimoxan to a blanket of diptera or hematophageal insects at an application rate of from about 1 gram (g) to about 1000 grams (g) of benzpyrimoxan per hectare (ha) of blanket or a surface thereof. In certain embodiments, the methods may comprise applying benzpyrimoxan or a larvicidal composition comprising benzpyrimoxan to a blanket at an application rate of from about 1 g active agent / ha to about 750 g active agent / ha, or from about 1 g active agent / ha to about 500 g active agent / ha, or from about 1 g active agent / ha to about 250 g active agent / ha, or from about 1 g active agent / ha to about 150 g active agent / ha, or from about 25 g active agent / ha to about 150 g active agent / ha, or from about 5 g active ingredient / ha to about 250 g active ingredient / ha, or from about 50 g active ingredient / ha to about 500 g active ingredient / ha, or from about 150 g active ingredient / ha to about 350 g active ingredient / ha, or from about 250 g active ingredient / ha to about 750 g active ingredient / ha, or from about 500 g active ingredient / ha to about 750 g active ingredient / ha, or from about 500 g active ingredient / ha to about 1000 g active ingredient / ha.The methods disclosed herein may also include contacting larvae with about 0.5 to about 15 ppm of benzopyrimoxan or a salt, solute, hydrate, or solvate thereof. The methods disclosed herein may also include contacting larvae with about 1.0 to about 10.0 ppm of benzopyrimoxan or a salt, solute, hydrate, or solvate thereof. The methods may also include contacting larvae with an aqueous incubation environment or composition comprising about 0.5 to about 15 ppm of benzpyrimoxane or a salt, solute, hydrate, or solvate thereof. In other embodiments, the methods may include contacting larvae with an aqueous incubation environment or composition comprising from about 1.0 to about 10.0 ppm of benzpyrimoxane or a salt, solute, hydrate, or solvate thereof. In certain embodiments, the methods may include causing larvae or a population of larvae to be contacted with a composition or an aqueous blanket comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof, or causing larvae or a population of larvae to be contacted with a composition or an aqueous blanket comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof. In other embodiments, the methods may include applying a larvicidal composition comprising benzpyrimoxan to a blanket to cause larvae or a population of larvae to be contacted with a composition or an aqueous blanket comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof, or may include applying a larvicidal composition comprising benzpyrimoxan to a blanket to cause larvae or a population of larvae to be contacted with a composition or an aqueous blanket comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.The methods disclosed herein may be effective in killing or preventing depopulation of larvae belonging to any of the species of disease-bearing diptera or hematophageal insects. Examples of disease-bearing diptera or hematophageal insects may include, but are not limited to, mosquitos, rubble mosquitos, houseflies, sandflies, tsetseflies, chrysopsflies (hirschl flies / goldflies), ticks, lice, fleas, midges, predances, and triatoniae. In addition, the methods and compositions disclosed herein may be effective in killing or preventing depopulation of diptera or hematophage larvae resistant to insecticides. Accordingly, the methods and compositions disclosed herein can be effective for controlling populations of adult vector or disease-bearing diptera or hematophageal insects, or effective for preventing or attenuating the transmission of one or more diseases transmitted by diptera or hematophageal insects to a human or animal who owns a vector control area in which the method or compositions are applied. The methods are effective in preventing or attenuating the transmission of one / more infectious agents or diseases transmitted by diptera or hematophageal insects. Non-limiting examples of infectious diseases or infectious diseases in which the methods disclosed herein may be effective in attenuating include African trypanosomiasis (sleep disorder), filariosis, onchocercosis, liasis (African eyeworm), leishmaniasis, leishmania, trypanosoma, onchocerca volvulus, loa loa, wuchereria bancrofti, brugia malayi, brugia timori, and trypanosomes.In certain aspects of the present disclosure, the methods disclosed herein may be particularly suitable for killing mosquito larvae or preventing mosquito larvae or pupae from developing into adult, lancing and / or disease-bearing mosquitos. The methods disclosed herein may include contacting a mosquito larvae population, environment or surface likely to contact one or more mosquito larvae or breeding mosquitos with a pesticidally effective amount of benzopyrimoxane or a salt, solute, hydrate or solvate thereof. The method may also include treating a mosquito breeding environment with a pesticidally effective amount of benzopyrimoxan or a salt, solute, hydrate or solvate thereof. In other embodiments, treating the mosquito breeding environment, or contacting mosquito larvae or a population of mosquito larvae, may include treating a mosquito breeding environment with any of the presently disclosed larvicidal compositions comprising benzpyrimoxan, or a salt, solute, hydrate, or solvate thereof. The method may also include, at least in some embodiments, spraying one of the liquid larvicide compositions disclosed herein into the mosquito breeding environment or onto a surface thereof. The method may also include spraying the liquid larvicide composition into the mosquito brood environment or onto a surface thereof using a backpack sprayer, a truck mounted sprayer, a boat mounted sprayer, a drone mounted sprayer, or an aircraft mounted sprayer.As used herein, the term "mosquito breeding environment" in all forms thereof refers to any environment that includes or encompasses one or more mosquito larvae, or any environment or surface where female mosquitos can deposit or brute eggs. The mosquito brood environment may be a natural environment, such as a standing body of water, or may be a man-made environment, such as a container, insect rubtrap, or other object likely to be used as a mosquito brood environment from a female bruting mosquito. Non-limiting examples of mosquito breeding environments may include rinnes, cisterns, water troughs for farm animals, ponds for farm animals, water locations, water storage containers, buckets, rain barrels, fountains, gutters, downcomers, non-chlorinated swimming pools, and pool covers in which water collects, tires, tree cavities, open waters, standing waters, silent waters, running waters, small rivers, bachs, gulys, and plant vessels or reducers.In certain embodiments, the mosquito brood environment may be a surface or container that is / is expected to absorb water or wet. In such embodiments, the methods may include treating a surface or container likely to absorb or wet water with a larvicidal composition comprising benzopyrimoxane or a salt, solute, hydrate, or solvate thereof. In certain embodiments, the method may include applying a larvicidal composition comprising benzopyrimoxan, or a salt, solute, hydrate, or solvate thereof, to the surface or container likely to absorb / wet water.In other embodiments, the mosquito brood environment may be a standing body of water. In such cases, the methods disclosed herein may include treating a standing body of water with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate, or solvate thereof. In certain embodiments, the methods may include applying a larvicidal composition comprising benzopyrimoxan, or a salt, solute, hydrate, or solvate thereof, to the standing body of water. The standing body of water may contain one or more mosquito larvae or be a mosquito breeding environment that may be sought in the future or after treatment of female breeding mosquitos.In certain embodiments of the methods disclosed herein, the mosquito rubbish environment may be a mosquito rubbish trap. In such cases, the methods may further include incorporating a larvicidal composition comprising benzpyrimoxan into a reservoir of a mosquito rublet. The methods may also include causing a larvicidal composition comprising benzpyrimoxan to be disposed in a reservoir of a mosquito rublet and / or loading a larvicidal composition comprising benzpyrimoxan into a reservoir of a mosquito rublet. In certain embodiments, the mosquito slide trap may be intended for use in an external environment. The mosquito rublet may also include a means for holding water. In some embodiments, the mosquito rubbish may include a reservoir capable of receiving and containing water. The mosquito rubbish trap may also include a means for receiving and containing rainwater in the reservoir or a means for holding water. The mosquito rubbish may further include a means for attracting one or more female mosquitos. The means for attracting one or more female mosquitos may include, for example, one or more chemical or biological attractants. In certain embodiments, the means for attracting one or more female mosquitos can include one or more pheromones or hormones.The methods may include applying benzpyrimoxan to a mosquito brood environment at an application rate of about 1 g / ha of active agent to about 1000 g / ha of active agent, or applying a larvicidal composition comprising benzpyrimoxan to a mosquito brood environment at an application rate of about 1 gram (g) to about 1000 gram (g) of benzpyrimoxan per hectare (ha) of mosquito brood environment, or a surface thereof. In certain embodiments, the methods may include applying benzpyrimoxan or a larvicidal composition containing benzpyrimoxan, In a mosquito breeding environment, at an application rate of from about 1 g active ingredient / ha to about 750 g active ingredient / ha, or from about 1 g active ingredient / ha to about 500 g active ingredient / ha, or from about 1 g active ingredient / ha to about 250 g active ingredient / ha, or from about 1 g active ingredient / ha to about 150 g active ingredient / ha, or from about 25 g active ingredient / ha to about 150 g active ingredient / ha, or from about 5 g active ingredient / ha to about 250 g active ingredient / ha, or from about 50 g active ingredient / ha to about 500 g active ingredient / ha, or from about 150 g active ingredient / ha to about 350 g active ingredient / ha, or from about 250 g active ingredient / ha to about 750 g active ingredient / ha, or from about 500 g active ingredient / ha to about 750 g active ingredient / ha, or from about 500 g active ingredient / ha to about 1000 g The active substance / ha can be.The methods may also include contacting mosquito larvae with about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof, or contacting mosquito larvae with about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof. In other embodiments, the methods may include contacting mosquito larvae with an aqueous blanket or composition comprising about 0.5 to about 15 ppm of benzopyrimoxan or a salt, solute, hydrate, or solvate thereof, or contacting mosquito larvae with an aqueous blanket or composition comprising about 1.0 to about 10.0 ppm of benzopyrimoxan or a salt, solute, hydrate, or solvate thereof. In still other embodiments, the methods may include causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or an aqueous blanket comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof, or causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or an aqueous blanket comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.In certain embodiments, the methods disclosed herein may include applying a larvicidal composition comprising benzpyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae to contact a composition or a breeding aqueous environment comprising about 0.5 ppm to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof, or may include applying a larvicidal composition comprising benzpyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae with a composition or a breeding aqueous environment comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, The solution, hydrate or solvate thereof may be contacted. The methods may also include contacting mosquito larvae with about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml of mosquito breeding environment, or contacting mosquito larvae with about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml of mosquito breeding environment. The methods may also include contacting mosquito larvae with an aqueous breeding environment or composition comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxane per ml of aqueous mosquito breeding environment or composition, or contacting mosquito larvae with an aqueous breeding environment or composition comprising about 0.001 mg to about 0.01 mg of benzpyrimoxane per ml of aqueous mosquito breeding environment or composition.The methods may also include causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or a blanket aqueous environment comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml of composition or blanket aqueous environment, or causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or blanket aqueous environment comprising about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml of composition or blanket aqueous environment. In certain embodiments, the methods may include applying a larvicidal composition comprising benzopyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae to contact a composition or an aqueous breeding environment comprising about 0.0005 mg to about 0.05 mg of benzopyrimoxan per ml, or may include applying a larvicidal composition comprising benzopyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae to contact a composition or an aqueous breeding environment comprising about 0.001 mg to about 0.01 mg of benzopyrimoxan per ml.In other embodiments, treating a mosquito breeding environment with a larvicidal composition may include depositing or applying a solid larvicidal composition into the mosquito breeding environment or onto a surface of the mosquito breeding environment. In such cases, the solid larvicide composition may be capable of dissolving or dispersing when wet or in contact with water. Non-limiting examples of solid larvicide compositions may include a tablet, pellet, briquettes, granules, wettable granule formulation, or sachet comprising wettable granule formulation.The methods disclosed herein may be effective in killing or preventing the depopulation of larvae of mosquitos belonging to any of the species of disease-bearing mosquito. Examples of disease-bearing mosquitos include, but are not limited to, mosquitos of the genera Anopheles, Culex, or Aedes. Further non-limiting examples of disease-bearing mosquitos may include Anopheles gambiae, Anopheles funestus, Aedes aegypti, Culex quinquefasciatus, Anopheles stephensi, and Aedes albopictus. The methods disclosed herein may be particularly useful in killing larvae of mosquitos classified as outdoor-stinging and outdoor-resting mosquitos. In addition, the methods and compositions disclosed herein can be effective in killing or preventing the depopulation of insecticide resistant mosquito larvae. Non-limiting examples of insecticides against which the treated mosquito larvae may be resistant are benzyl ureas, methoprene, S-methoprene, S-kinoprene, S-hydropen, temephos, pyrethroids, DDT, carbamates and organophosphates. Accordingly, the methods and compositions disclosed herein may be effective in controlling populations of adult vector or disease-bearing mosquitos or effective in preventing or attenuating the transmission of one or more mosquito-bearing diseases to a human or animal who / she owns a vector control area in which the method or compositions are applied. In particular, the methods and compositions disclosed herein may be effective for controlling or ameliorating any mosquito-mediated disease, including, but not limited to, malaria, yellow fever, dengue fever, Zika virus, west nile virus, chikungunya virus, equine eastern encephalitis virus, Japanese encephalitis virus, La cross encephalitis, and St. Louis encephalitis.The present disclosure also provides a mosquito rublet capable of killing mosquito larvae and / or controlling populations of adult mosquitos. The mosquito slide trap may include a reservoir configured to hold or contain water and capable of receiving one or more female mosquitos. The reservoir may be further capable of containing any of the presently disclosed larvicidal compositions comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof. The mosquito rublet may further include a larvicidal benzpyrimoxan composition disposed or contained within the reservoir of the mosquito rublet. At least in some embodiments, the reservoir may be further capable of receiving and collecting rainwater. The mosquito rubbish may also include a means for attracting one or more female mosquitos. The means for attracting one or more female mosquitos may include, for example, one or more chemical or biological attractants. In certain embodiments, the means for attracting one or more female mosquitos can include one or more pheromones or hormones.In certain embodiments, the mosquito slide trap may further include a means that allows a mosquito to enter the trap and / or the reservoir while delaying or slowing the egress of the mosquito from the trap and / or the reservoir. For example, the mosquito trap may include a funnel portion or cover that is adapted to allow a mosquito to enter the trap or reservoir, but at the same time make it difficult for the mosquito to leave the trap or reservoir.The present disclosure also provides a breeder trap for diptera or hematophage insects that is capable of killing larvae of diptera or hematophage insects and / or controlling populations of adult diptera or hematophage insects. The breeder trap for diptera or hematophageal insects may include a breeder compartment configured to contain one or more breeder diptera or hematophageal insects. The gross compartment is further capable of incorporating any of the presently disclosed larvicidal compositions comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof. In certain embodiments, the broadleaf trap for diptera or hematophageal insects may comprise or contain the larvicidal composition as well as an agent for attracting one or more firefly diptera or hematophageal insects. The means for attracting one or more Diptera or hematophageal insect breeding agents may include, for example, one or more chemical or biological attractants capable of attracting one or more Diptera or hematophageal insect breeding agents. In certain embodiments, the means for attracting one or more firefly diptera or hematophageal insects may be located near the breed compartment. In certain embodiments, the means for attracting one or more breeding diptera or hematophageal insects may be arranged in the breeding compartment. In certain embodiments, the means for attracting one or more firefly diptera or hematophageal insects may include one or more pheromones or hormones.In certain embodiments, the breeder trap for diptera or hematophageal insects may further include a means for allowing a diptera or hematophageal insect to enter the trap and / or breeder compartment while delaying or slowing the egress of the diptera or hematophageal insect from the trap and / or breeder compartment. For example, the breeder trap for diptera or hematophageal insects may include a funnel portion or cover capable of allowing the diptera or hematophageal insect to enter the trap or breeder compartment, but at the same time making it difficult for the insect to leave the trap or breeder compartment.EXAMPLESThe example provided below illustrates selected aspects of the presently disclosed compositions and methods for killing mosquito larvae and thereby controlling populations of adult mosquitos.Example 1The compositions and methods disclosed herein with benzpyrimoxan have been tested in biological assays for their effectiveness against the larvae of disease-bearing mosquitos, including pesticide resistant mosquitos. Specifically, benzpyrimoxan test solutions were prepared using a benzpyrimoxan stock solution formed by combining benzpyrimoxan and acetone in a mixing ratio of 1 mg (mg) of benzpyrimoxan per 1 ml of acetone. Benzpyrimoxane test solutions containing 10.0 ppm, 1.0 ppm, 0.1 ppm, 0.01 ppm, 0.001 ppm and 0.0001 ppm of benzpyrimoxane were prepared by diluting the benzpyrimoxane stock solution with water. Each test solution was placed in a round polypropylene test container 47 millimeters (mm) high and 100 mm in diameter. Ten (10) larvae stage 2 mosquito larvae were placed in each container, together with tetramine as feed source. Larvae were scored after one (1) day and then every two (2) to three (3) days until hatching. When the larvae pupate, the containers were capped.The rate of hatching of mosquito larvae from pupae to adult was determined for both Aedes aegypti and Anopheles stephensi mosquitos fourteen (14) days after treatment with the benzpyrimoxan test solution. The slip rate values versus the concentration of benzpyrimoxan in the test solutions are shown in Figure 1 for both pesticidally resistant and pesticidally acceptable Aedes aegypti larvae and in Figure 2 for Anopheles stephensi larvae. Error bars indicate the standard deviation (n=270 for FIG. 1 ; n=180 for FIG. 2 ). As shown in Figure 1, the slip rate of susceptible A. aegypti mosquito larvae decreased by about 25% when exposed to a 1.0 ppm benzpyrimoxane solution. When exposed to a 10.0 ppm benzpyrimoxan solution, 100% of the A. aegypti susceptable mosquito larvae were prevented from hatching and died, while over 90% of the A. aegypti pesticide resistant larvae did not hatching. As shown in Figure 2, the slip rate of An. stephensi mosquito larvae was decreased by over 90% when contacted with the 1.0 ppm of benzpyrimoxane solution.Mortality of A. aegypti and An. stephensi mosquito larvae was also determined for 1 ppm and 10 ppm of benzpyrimoxan test solutions during the fourteen (14) day test period (Figs. 3-4). Specifically, Figure 3 illustrates mortality of A. aegypti mosquito larvae after contact with a 10 ppm benzpyrimoxane test solution. Error bars indicate the standard deviation (n=270). As shown in Figure 3, significant mortality occurred 2 days after contact with the 10 ppm test solution, with maximum mortality observed 7 days after contact. After 7 days, over 90% of the susceptible and over 60% of the pesticidally resistant A. aegypti mosquito larvae were killed upon contact with the 10 ppm benzpyrimoxane test solution. Figure 4 illustrates mortality data for An. stephensiwhen exposed to either the 1 ppm or 10 ppm benzpyrimoxane test solution. Error bars indicate the standard deviation (n=180). As shown in Figure 4, 100% mortality was observed for An. stephensi larvae 2 days after contact with the 10 ppm benzpyrimoxan test solution. Upon contact with the 1 ppm test solution, greater than 50% mortality was observed after 2 days and 70% mortality was observed after 14 days.Other objects, features, and advantages of the disclosure will be apparent from the above-mentioned figures, detailed description, and examples. It should be understood, however, that the figures, detailed description, and examples, while indicating specific embodiments of the disclosure, are intended for purposes of illustration only and are not intended to be limiting. In further embodiments, features of certain embodiments may be combined with features of other embodiments. For example, features of one embodiment may be combined with features of any other embodiment. In other embodiments, additional features may be added to the specific embodiments described herein.Disclosure Statements:Statement 1: A method for killing mosquito larvae, the method comprising contacting mosquito larvae with a pesticidally effective amount of benzopyrimoxane or a salt, solute, hydrate, or solvate thereof.Statement 2: A method for controlling populations of adult mosquitos, said method comprising contacting mosquito larvae or a population of mosquito larvae with a pesticidally effective amount of benzopyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 3: A method for controlling mosquito populations, the method comprising treating a mosquito breeding environment with a pesticidally effective amount of benzopyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 4: The method of Statement 1 or Statement 2, wherein contacting mosquito larvae with a pesticidally effective amount of benzpyrimoxan comprises treating a mosquito breeding environment with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 5: The method of Statement 4, wherein treating a mosquito brood environment with a larvicidal composition comprises spraying a liquid larvicidal composition into or onto a surface of the mosquito brood environment.Statement 6: The method of Statement 5, wherein spraying a liquid larvicide composition comprises spraying the liquid larvicide composition using a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 7: The method of Statement 4, wherein treating a mosquito breeding environment with a larvicidal composition comprises depositing or applying a solid larvicidal composition to the mosquito breeding environment or to a surface thereof.Statement 8: The method of Statement 7, wherein the solid larvicide composition is capable of dissolving or dispersing when wet or contacting water.Statement 9: The method of Statement 7 or Statement 8, wherein the solid larvicide composition comprises a tablet, a pellet, a briquettes, granules, a wettable granule formulation, a sachet comprising a wettable granule formulation, or any combination thereof.Statement 10: The method of Statement 1 or Statement 2, wherein contacting mosquito larvae with a pesticidally effective amount of benzpyrimoxan comprises applying a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof to a mosquito breeding environment.Statement 11: The method of Statement 10, wherein applying a larvicidal composition to a breeding environment comprises spraying a liquid larvicidal composition into the mosquito breeding environment or onto a surface thereof.Statement 12: The method of Statement 11, wherein spraying a liquid larvicide composition comprises spraying the liquid larvicide composition using a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 13: The method of Statement 10, wherein applying a larvicidal composition to a breeding environment comprises depositing or applying a solid larvicidal composition to the mosquito breeding environment or to a surface thereof.Statement 14: The method of Statement 13, wherein the solid larvicide composition is capable of dissolving or dispersing when wet or contacting water.Statement 15: The method of Statement 13 or Statement 14, wherein the solid larvicide composition comprises a tablet, a pellet, a briquettes, granules, a wettable granule formulation, a sachet comprising a wettable granule formulation, or any combination thereof.Statement 16: The method according to any of Statements 3-15, wherein the mosquito breeding environment includes or comprises one or more mosquito larvae.Statement 17: The method according to any of Statements 3-15, wherein the mosquito breeding environment is an environment in which mosquitos can deposit or breed eggs.Statement 18: The method of any of Statements 3-15, wherein the mosquito breeding environment is selected from the group consisting of rinnes, cisterns, water troughs for livestock, ponds for livestock, water locations, water storage containers, buckets, rain barrels, fountains, gutters, downcomers, non-chlorinated swimming pools, pool covers that collect water, tires, tree cavities, open waters, standing waters, still waters, flowing waters, small flows, breds, gulvs, and plant vessels or subsiders.Statement 19: The method according to any of Statements 3-15, wherein the mosquito brood environment is a surface or container that is / is expected to absorb water or become wet.Statement 20: The method according to one of Statements 3-15, wherein the mosquito brood environment is a standing body of water.Statement 21: The method of Statement 1 or Statement 2, wherein contacting mosquito larvae with a pesticidally effective amount of benzpyrimoxan comprises treating a standing body of water with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 22: The method according to Statement 21, wherein the standing body of water contains or comprises one or more mosquito larvae.Statement 23: The method of Statement 21 or Statement 22, wherein treating a standing body of water with a larvicidal composition comprises applying to the standing body of water a larvicidal composition comprising benzpyrimoxane or a salt, solute, hydrate, or solvate thereof.Statement 24: The method of Statement 1 or Statement 2, wherein contacting mosquito larvae with a pesticidally effective amount of benzpyrimoxan comprises treating a surface or container likely to absorb / wet water with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 25: The method of Statement 24, wherein treating a surface or container suspected of receiving or wetting water with a larvicidal composition comprises applying a larvicidal composition comprising benzpyrimoxane or a salt, solute, hydrate, or solvate thereof to the surface or container suspected of receiving or wetting water.Statement 26: The method of any of Statements 4-25, wherein the larvicidal composition comprises a larvicidally effective amount of benzopyrimoxane.Statement 27: The method of any of Statements 4-26, wherein the larvicidal composition is capable of killing at least 90% of mosquito larvae contacted with the larvicidal composition.Statement 28: The method of any of Statements 4-26, wherein the larvicidal composition is capable of killing at least 95% of mosquito larvae contacted with the larvicidal composition.Statement 29: The method of any of Statements 4-26, wherein the larvicidal composition is capable of preventing at least 90% of mosquito larvae contacted with the larvicidal composition from depupping or otherwise becoming an adult mosquito.Statement 30: The method of any of Statements 4-26, wherein the larvicidal composition is capable of preventing at least 95% of mosquito larvae contacted with the larvicidal composition from depupping or otherwise forming an adult mosquito.Statement 31: The method of any of Statements 4-26, wherein the larvicidal composition is capable of causing at least 90% of the mosquito larvae contacted with the larvicidal composition to fail to depunc or otherwise form an adult mosquito.Statement 32: The method of any of Statements 4-26, wherein the larvicidal composition is capable of causing at least 95% of the mosquito larvae contacted with the larvicidal composition to fail to depunc or otherwise form an adult mosquito.Statement 33: The method of any of Statements 4-32, wherein the larvicidal composition comprises from about 0.05% to about 65% benzpyrimoxane by weight.Item 34: The method of any of Items 4-32, wherein the larvicidal composition comprises from about 1% to about 25% by weight of benzpyrimoxane.Item 35: The method of any of Items 4-32, wherein the larvicidal composition comprises from about 2% to about 15% by weight of benzpyrimoxane.Statement 36: The method of any of Statements 4-32, wherein the larvicidal composition comprises from about 5% to about 15% by weight of benzpyrimoxane.Statement 37: The method of any of Statements 4-32, wherein the larvicidal composition comprises less than 10% by weight of benzopyrimoxane.Statement 38: The method of any of Statements 1-31, further comprising applying benzpyrimoxan to a mosquito breeding environment at an application rate of about 1 g active ingredient / ha to about 1000 g active ingredient / ha.Statement 39: The method of any of Statements 1-31, further comprising applying a larvicidal composition comprising benzpyrimoxan to a mosquito brood environment at an application rate of from about 1 gram (g) to about 1000 grams (g) of benzpyrimoxan per hectare (ha) mosquito brood environment, or a surface area thereof.Statement 40: The method of any of Statements 1-39, further comprising contacting mosquito larvae with about 0.5 to about 15 ppm of benzpyrimoxane or a salt, solute, hydrate, or solvate thereof.Statement 41: The method of any of Statements 1-39, further comprising contacting mosquito larvae with about 1.0 to about 10.0 ppm of benzopyrimoxane or a salt, solute, hydrate, or solvate thereof.Statement 42: The method of any of Statements 1-39, further comprising contacting mosquito larvae with an aqueous breeding environment or composition comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 43: The method of any of Statements 1-39, further comprising contacting mosquito larvae with an aqueous breeding environment or composition comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 44: The method of any of Statements 1-39, further comprising causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or an aqueous breeding environment comprising about 0.5 to about 15 ppm of benzopyrimoxane or a salt, solute, hydrate or solvate thereof.Statement 45: The method of any of Statements 1-39, further comprising causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or an aqueous breeding environment comprising about 1.0 to about 10.0 ppm of benzopyrimoxane or a salt, solute, hydrate, or solvate thereof.Statement 46: The method of any of Statements 1-39, further comprising applying a larvicidal composition comprising benzpyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae to contact a composition or an aqueous breeding environment comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 47: The method of any of Statements 1-39, further comprising applying a larvicidal composition comprising benzpyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae to contact a composition or an aqueous breeding environment comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 48: The method of any of Statements 1-39, further comprising contacting mosquito larvae with about 0.0005 mg to about 0.05 mg of benzopyrimoxan per ml of mosquito breeding environment.Statement 49: The method of any of Statements 1-39, further comprising contacting mosquito larvae with about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml mosquito breeding environment.Statement 50: The method of any of Statements 1-39, further comprising contacting mosquito larvae with an aqueous breeding environment or composition comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml of aqueous mosquito breeding environment or composition.Statement 51: The method of any of Statements 1-39, further comprising contacting mosquito larvae with an aqueous breeding environment or composition comprising about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml of aqueous mosquito breeding environment or composition.Statement 52: The method of any of Statements 1-39, further comprising causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or an aqueous breeding environment comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml of composition or aqueous mosquito breeding environment.Statement 53: The method of any of Statements 1-39, further comprising causing mosquito larvae or a population of mosquito larvae to be contacted with a composition or an aqueous breeding environment comprising about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml of composition or aqueous mosquito breeding environment.Statement 54: The method of any of Statements 1-39, further comprising applying a larvicidal composition comprising benzpyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae to contact a composition or an aqueous breeding environment comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml.Statement 55: The method of any of Statements 1-39, further comprising applying a larvicidal composition comprising benzpyrimoxan to a mosquito breeding environment to cause mosquito larvae or a population of mosquito larvae to contact a composition or an aqueous breeding environment comprising about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml.Statement 56: The method of any of Statements 4-55, wherein the larvicidal composition further comprises one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen, temephos, and any combination thereof.Statement 57: The method of any of Statements 4-56, wherein the larvicidal composition further comprises one or more further larvicides selected from the group consisting of Bacillus thuringiensis israelensis, Bacillus sphaericus, and any combination thereof.Statement 58: The method according to any of Statements 4-57, wherein the larvicidal composition further comprises one or more further larvicides from the benzylurea family.Statement 59: The method of any of Statements 4-58, wherein the larvicidal composition further comprises 2,6-difluorobenzylurea.Statement 60: The method of any of Statements 4-58, wherein the larvicidal composition further comprises one or more mineral oils and / or monomolecular films.Statement 61: The method according to any of Statements 4-57, wherein the larvicidal composition excludes or does not contain a larvicide from the benzylurea family.Statement 62: The method of any of Statements 4-57, wherein the larvicidal composition excludes or does not contain 2,6-difluorobenzylurea.Statement 63: The method according to any of Statements 4-55, wherein the larvicidal composition excludes or does not contain one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen and temephos.Statement 64: The method according to any of Statements 4-55, wherein the larvicidal composition excludes or does not contain Bacillus thuringiensis israelensisand / or Bacillus sphaericus.Statement 65: The method of any of Statements 4-64, wherein the larvicidal composition is in the form of a formulation selected from the group consisting of an emulsifiable concentrate (EK), an emulsion-in-water (EW), a suspension concentrate (SK), a suspoemulsion (SE), a flowable concentrate (FK), a wettable powder (BP), a soluble liquid concentrate (LFK), a soluble powder (LP), an ultra-low-volume spray (ULV), and any combination thereof.Statement 66: The method of any of Statements 4-64, wherein the larvicidal composition is in the form of a liquid formulation suitable for dilution with water before application to a mosquito brood environment or surface thereof.Statement 67: The method of Statement 66, wherein the larvicidal composition is a liquid concentrated larvicidal composition.Statement 68: The method of any of Statements 4-64, wherein the larvicidal composition is a liquid larvicidal composition suitable for spraying with a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 69: The method of any of Statements 66-68, wherein the liquid formulation or liquid larvicide composition comprises water and / or one or more solvents.Statement 70: The method of any of Statements 4-64, wherein the larvicidal composition is a solid larvicidal composition capable of dissolving or dispersing when wet or in contact with water.Statement 71: The method of any of Statements 4-64, wherein the larvicidal composition is a solid larvicidal composition in the form of a tablet, a pellet, a briquettes, a granule, a wettable granule formulation, a pouch comprising a wettable granule formulation, or any combination thereof.Statement 72: The method according to any of Statements 1-71, wherein the mosquito larvae belong to the genus Anopheles, Culex or Aedes.Statement 73: The method according to any one of Statements 1-71, wherein the mosquito larvae are selected from the group consisting of Anopheles gambiae, Anopheles funestus, Aedes aegypti, Culex quinquefasciatus, Anopheles stephensi and Aedes albopictus.Statement 74: The method according to any one of Statements 1-71, wherein the mosquito larvae are classified as mosquitos which are stinging outdoors and resting outdoors.Statement 75: The method according to any one of Statements 1-74, wherein the mosquito larvae are resistant to one or more insecticides.Statement 76: The method of Statement 75, wherein the one or more insecticides are selected from the group consisting of pyrethroids, DDT, carbamates, and organophosphates.Statement 77: The method of any of Statements 4-76, wherein the larvicidal composition is substantially free of an insecticide or larvicide other than benzpyrimoxane.Statement 78: The method of any of Statements 1-77, the method effective to prevent or mitigate transmission of one or more mosquito-mediated diseases to a human or animal owning a vector control area in which the method is applied, wherein the one or more mosquito-mediated diseases are selected from the group consisting of malaria, yellow fever, dengue fever, Zika virus, west nile virus, chikungunya virus, equine eastern encephalitis virus, Japanese encephalitis virus, La cross encephalitis and St. Louis encephalitis.Statement 79: The method according to any of Statements 3-78, wherein the mosquito rub environment is a mosquito rub trap.Statement 80: The method of any of Statements 1-79, further comprising introducing a larvicidal composition comprising benzopyrimoxan into a reservoir of a mosquito rublet.Statement 81: The method of any of Statements 1-79, further comprising causing a larvicidal composition comprising benzopyrimoxan to be disposed in a reservoir of a mosquito rublet.Statement 82: The method of any of Statements 1-79, further comprising loading a larvicidal composition comprising benzopyrimoxan into a reservoir of a mosquito rublet.Statement 83: The method according to any of Statements 79-82, wherein the mosquito slide trap is intended for use in an external environment, wherein the mosquito slide trap comprises a means for holding water.Statement 84: The method of Statement 83, wherein the mosquito rublet trap comprises a reservoir capable of receiving and containing water.Statement 85: The method of Statement 83 or Statement 84, wherein the mosquito rublet includes a means for receiving and containing rainwater in the reservoir or a means for holding water.Statement 86: The method of Statement 84 or Statement 85, wherein the mosquito rubbish trap further comprises a means for attracting one or more female mosquitos.Statement 87: The method of Statement 85, wherein the means for attracting one or more female mosquitos comprises one or more chemical or biological attractants.Statement 88: A larvicidal composition for killing mosquito larvae, wherein the larvicidal composition comprises a pesticidally effective amount of benzopyrimoxane or a salt, solute, hydrate or solvate thereof.Statement 89: The larvicidal composition of Statement 88, wherein the larvicidal composition comprises a larvicidally effective amount of benzpyrimoxane.Statement 90: The larvicidal composition of Statement 88 or Statement 89, wherein the larvicidal composition is capable of killing at least 90% of mosquito larvae contacted with the larvicidal composition.Statement 91: The larvicidal composition of Statement 88 or Statement 89, wherein the larvicidal composition is capable of killing at least 95% of mosquito larvae contacted with the larvicidal composition.Statement 92: The larvicidal composition of Statement 88 or Statement 89, wherein the larvicidal composition is capable of preventing at least 90% of the mosquito larvae contacted with the larvicidal composition from depupping or otherwise forming an adult mosquito.Statement 93: The larvicidal composition of Statement 88 or Statement 89, wherein the larvicidal composition is capable of preventing at least 95% of the mosquito larvae contacted with the larvicidal composition from depupping or otherwise forming an adult mosquito.Statement 94: The larvicidal composition of Statement 88 or Statement 89, wherein the larvicidal composition is capable of causing at least 90% of the mosquito larvae contacted with the larvicidal composition to fail to depunc or otherwise form an adult mosquito.Statement 95: The larvicidal composition of Statement 88 or Statement 89, wherein the larvicidal composition is capable of causing at least 95% of the mosquito larvae contacted with the larvicidal composition to fail to depunc or otherwise form an adult mosquito.Statement 96: The larvicidal composition of any of Statements 88-95, wherein the larvicidal composition comprises from about 0.05% to about 65% benzpyrimoxane by weight.Statement 97: The larvicidal composition of any of Statements 88-95, wherein the larvicidal composition comprises from about 1% to about 25% by weight of benzpyrimoxane.Statement 98: The larvicidal composition of any of Statements 88-95, wherein the larvicidal composition comprises about 2% to about 15% by weight of benzpyrimoxane.Statement 99: The larvicidal composition of any of Statements 88-95, wherein the larvicidal composition comprises about 5% to about 15% by weight of benzpyrimoxane.Statement 100: The larvicidal composition of any of Statements 88-95, wherein the larvicidal composition comprises less than 10% by weight of benzpyrimoxane.Statement 101: The larvicidal composition according to any of statements 88-100, wherein the larvicidal composition further comprises one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen, temephos and any combination thereof.Statement 102: The larvicide composition according to any one of statements 88-101, wherein the larvicide composition further comprises one or more further larvicides selected from the group consisting of Bacillus thuringiensis israelensis, Bacillus sphaericus, and any combination thereof.Statement 103: The larvicide composition according to any of Statements 88-102, wherein the larvicide composition further comprises one or more further larvicides from the benzylurea family.Statement 104: The larvicidal composition of any of Statements 88-103, wherein the larvicidal composition further comprises 2,6-difluorobenzylurea.Statement 105: The larvicidal composition of any of Statements 88-104, wherein the larvicidal composition further comprises one or more mineral oils and / or monomolecular films.Statement 106: The larvicide composition according to any one of Statements 88-100, wherein the larvicide composition excludes or does not contain a larvicide from the benzylurea family.Statement 107: The larvicidal composition of any of Statements 88-100, wherein the larvicidal composition excludes or does not contain 2,6-difluorobenzylurea.Statement 108: The larvicidal composition according to any of Statements 88-100, wherein the larvicidal composition excludes or does not contain one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen and temephos.Statement 109: The larvicidal composition according to any of Statements 88-100, wherein the larvicidal composition excludes or does not contain Bacillus thuringiensis israelensis and / or Bacillus sphaericus.Statement 110: The larvicidal composition of any of Statements 88-109, wherein the larvicidal composition is in the form of a formulation selected from the group consisting of an emulsifiable concentrate (EK), an emulsion-in-water (EW), a suspension concentrate (SK), a suspoemulsion (SE), a flowable concentrate (FK), a wettable powder (BP), a soluble liquid concentrate (LFK), a soluble powder (LP), an ultra-low volume spray (ULV), and any combination thereof.Statement 111: The larvicidal composition of any of Statements 88-109, wherein the larvicidal composition is in the form of a liquid formulation that can be diluted with water before being applied to a mosquito breeding environment or a surface thereof.Statement 112: The larvicidal composition of Statement 111, wherein the larvicidal composition is a liquid concentrated larvicidal composition.Statement 113: The larvicide composition according to any one of Statements 88-109, wherein the larvicide composition is a liquid larvicide composition suitable for spraying with a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 114: The larvicidal composition according to any of Statements 111-113, wherein the liquid formulation or liquid larvicidal composition comprises water and / or one or more solvents.Statement 115: The larvicidal composition of any of Statements 88-109, wherein the larvicidal composition is a solid larvicidal composition capable of dissolving or dispersing when wet or contacting water.Statement 116: The larvicidal composition of any one of Statements 88-109 and 115, wherein the larvicidal composition is a solid larvicidal composition in the form of a tablet, a pellet, a briquet, a granule, a wettable granule formulation, a pouch comprising a wettable granule formulation, or any combination thereof.Statement 117: The larvicide composition of any one of Statements 88-117, wherein the mosquito larvae belong to the genus Anopheles, Culex, or Aedes.Statement 118: The larvicidal composition according to any of Statements 88-117, wherein the mosquito larvae are selected from the group consisting of Anopheles gambiae, Anopheles funestus, Aedes aegypti, Culex quinquefasciatus, Anopheles stephensi and Aedes albopictus.Statement 119: The larvicide composition of any of Statements 88-117, wherein the mosquito larvae are classified as being mosquitos that are free-standing and non-free-resting.Statement 120: The larvicidal composition according to any of Statements 88-117, wherein the mosquito larvae are resistant to one or more insecticides.Statement 121: The larvicidal composition of Statement 120, wherein the one or more insecticides are selected from the group consisting of pyrethroids, DDT, carbamates, and organophosphates.Statement 122: The larvicidal composition of any one of Statements 88-121, wherein the larvicidal composition is substantially free of an insecticide or larvicide other than benzpyrimoxane.Statement 123: A method for killing larvae of a dipteran insect or a hematophage insect species, said method comprising contacting insect larvae with a pesticidally effective amount of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 124: A method for controlling populations of adult diptera, the method comprising contacting diptera larvae or a population of diptera larvae with a pesticidally effective amount of benzpyrimoxane or a salt, solute, hydrate or solvate thereof.Statement 125: A method for controlling populations of diptera insects, the method comprising treating a diptera breeding environment with a pesticidally effective amount of benzopyrimoxane or a salt, solute, hydrate or solvate thereof, wherein the diptera breeding environment may optionally be selected from the group consisting of rottenating organic material, animal fecal, and a feed source for diptera larvae.Statement 126: The method of Statement 123 or Statement 124, wherein contacting larvae with a pesticidally effective amount of benzopyrimoxan comprises treating a diptere breeding environment with a larvicidal composition comprising benzopyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 127: The method of Statement 126, wherein treating a diptere breeding environment with a larvicidal composition comprises spraying a liquid larvicidal composition into or onto a surface of the diptere breeding environment, wherein the diptere breeding environment can optionally be selected from the group consisting of rotting organic material, animal fecal, and a feed source for diptere larvae.Statement 128: The method of Statement 127, wherein spraying a liquid larvicide composition comprises spraying the liquid larvicide composition using a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 129: The method of Statement 125, wherein treating a diptere rub environment with a larvicidal composition comprises depositing or applying a solid larvicidal composition into or to a surface of the diptere rub environment.Statement 130: The method of Statement 129, wherein the solid larvicide composition is capable of dissolving or dispersing when wet or contacting water.Statement 131: The method of Statement 129 or Statement 130, wherein the solid larvicide composition comprises a tablet, a pellet, a briquettes, granules, a wettable granule formulation, a sachet comprising a wettable granule formulation, or any combination thereof.Statement 132: The method of Statement 123 or Statement 124, wherein contacting larvae with a pesticidally effective amount of benzopyrimoxan comprises applying a larvicidal composition comprising benzopyrimoxan or a salt, solute, hydrate or solvate thereof to a breed environment for diptera or hematophage insects.Statement 133: The method of Statement 132, wherein applying a larvicidal composition to a breeding environment comprises spraying a liquid larvicidal composition into the breeding environment or onto a surface thereof.Statement 134: The method of Statement 133, wherein spraying a liquid larvicide composition comprises spraying the liquid larvicide composition using a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 135: The method of Statement 132, wherein applying a larvicidal composition to a breeding environment comprises depositing or applying a solid larvicidal composition to the breeding environment or to a surface thereof.Statement 136: The method of Statement 135, wherein the solid larvicide composition is capable of dissolving or dispersing when wet or contacting water.Statement 137: The method of Statement 135 or Statement 136, wherein the solid larvicide composition comprises a tablet, a pellet, a briquettes, granules, a wettable granule formulation, a sachet comprising a wettable granule formulation, or any combination thereof.Statement 138: The method of any one of Statements 125-137, wherein the breeding environment contains or comprises one or more larvae of diptera or hematophageal insects.Statement 139: The method of any one of Statements 125-138, wherein the breeding environment is an environment in which diptera or hematophageal insects can deposit or breed eggs.Statement 140: The method of any of Statements 125-139, wherein the breeding environment is selected from the group consisting of rinnsteins, cisterns, water troughs for livestock, ponds for livestock, water locations, water storage containers, buckets, rain barrels, fountains, fountains, gutters, downcomers, non-chlorinated swimming pools, pool covers that collect water, tires, tree cavities, open waters, standing waters, silent waters, flowing waters, small rivers, bachs, gulys, and plant vessels or substorses.Statement 141: The method according to any of Statements 125-140, wherein the breeding environment is a surface or container that is / is expected to absorb water or wet.Statement 142: The method according to one of the statements 125-141, wherein the breeding environment is a standing body of water.Statement 143: The method of Statement 123 or Statement 124, wherein contacting larvae with a pesticidally effective amount of benzopyrimoxan comprises treating a standing body of water with a larvicidal composition comprising benzopyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 144: The method of Statement 143, wherein the standing body of water contains or comprises one or more larvae of diptera or hematophageal insects.Statement 145: The method of Statement 143 or Statement 144, wherein treating a standing body of water with a larvicidal composition comprises applying to the standing body of water a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 146: The method of Statement 123 or Statement 124, wherein contacting larvae with a pesticidally effective amount of benzpyrimoxan comprises treating a surface or container likely to absorb water or wet with a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 147: The method of Statement 146, wherein treating a surface or container suspected of receiving or wetting water with a larvicidal composition comprises applying a larvicidal composition comprising benzpyrimoxan or a salt, solute, hydrate or solvate thereof to the surface or container suspected of receiving or wetting water.Item 148: The method of any of Items 126-147 wherein the larvicidal composition comprises a larvicidally effective amount of benzpyrimoxane.Statement 149: The method of any of Statements 126-148, wherein the larvicidal composition is capable of killing at least 90% of larvae contacted with the larvicidal composition.Statement 150: The method of any of Statements 126-148, wherein the larvicidal composition is capable of killing at least 95% of larvae contacted with the larvicidal composition.Statement 151: The method of any of Statements 126-148, wherein the larvicidal composition is capable of preventing at least 90% of the larvae contacted with the larvicidal composition from depupping or otherwise forming an adult insect.Statement 152: The method of any of Statements 126-148, wherein the larvicidal composition is capable of preventing at least 95% of the larvae contacted with the larvicidal composition from depupping or otherwise forming an adult insect.Statement 153: The method of any of Statements 126-148, wherein the larvicidal composition is capable of causing at least 90% of the larvae contacted with the larvicidal composition to fail to depupp or otherwise form an adult insect.Statement 154: The method of any one of Statements 126-148, wherein the larvicidal composition is capable of causing at least 95% of the larvae contacted with the larvicidal composition to not unpuppled or otherwise form an adult insect.Item 155: The method of any of Items 126-154, wherein the larvicidal composition comprises about 0.05% to about 65% benzpyrimoxane by weight.Item 156: The method of any of Items 126-154, wherein the larvicidal composition comprises about 1% to about 25% by weight of benzpyrimoxane.Item 157: The method of any of Items 126-154, wherein the larvicidal composition comprises from about 2% to about 15% benzpyrimoxane by weight.Item 158: The method of any of Items 126-154, wherein the larvicidal composition comprises about 5 wt% to about 15 wt% benzpyrimoxane.Statement 159: The method of any one of Statements 126-154, wherein the larvicidal composition comprises less than 10% by weight of benzopyrimoxane.Statement 160: The method of any one of Statements 123-159, further comprising applying benzopyrimoxan to a blanket of diptera or hematophageal insects at an application rate of from about 1 g / ha of active agent to about 1000 g / ha of active agent.Statement 161: The method of any of Statements 123-159, further comprising applying a larvicidal composition comprising benzpyrimoxan to a breeding environment of diptera or hematophageal insects at an application rate of from about 1 gram (g) to about 1000 grams (g) of benzpyrimoxan per hectare (ha) breeding environment or a surface thereof.Statement 162: The method of any one of Statements 123-159, further comprising contacting larvae with about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 163: The method of any one of Statements 123-159, further comprising contacting larvae with about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 164: The method of any one of Statements 123-159, further comprising contacting larvae with an aqueous blanket or composition comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 165: The method of any one of Statements 123-159 further comprising contacting larvae with an aqueous incubation environment or composition comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 166: The method of any one of Statements 123-159, further comprising causing larvae or a population of larvae to contact a composition or an aqueous breeding environment comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 167: The method of any one of Statements 123-159, further comprising causing larvae or a population of larvae to contact a composition or an aqueous breeding environment comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 168: The method of any one of Statements 123-159, further comprising applying a larvicidal composition comprising benzpyrimoxan to a blanket to cause larvae or population of larvae to contact a composition or blanket aqueous environment comprising about 0.5 to about 15 ppm of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 169: The method of any of Statements 123-159, further comprising applying a larvicidal composition comprising benzpyrimoxan to a blanket to cause larvae or population of larvae to contact a composition or blanket comprising about 1.0 to about 10.0 ppm of benzpyrimoxan or a salt, solute, hydrate, or solvate thereof.Statement 170: The method of any one of Statements 123-159, further comprising contacting larvae with about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml of incubation environment.Statement 171: The method of any one of Statements 123-159, further comprising contacting larvae with about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml of incubation environment.Statement 172: The method of any one of Statements 123-159, further comprising contacting larvae with an aqueous blanket or composition comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml of aqueous blanket or composition.Statement 173: The method of any one of Statements 123-159, further comprising contacting larvae with an aqueous blanket or composition comprising about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml of aqueous blanket or composition.Statement 174: The method of any one of Statements 123-159, further comprising causing larvae or a population of larvae to contact a composition or an aqueous breeding environment comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml of composition or aqueous breeding environment.Statement 175: The method of any one of Statements 123-159, further comprising causing larvae or a population of larvae to contact a composition or an aqueous breeding environment comprising about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml of composition or aqueous breeding environment.Statement 176: The method of any one of Statements 123-159, further comprising applying a larvicidal composition comprising benzpyrimoxan to a breeding environment to cause larvae or population of larvae to contact a composition or breeding aqueous environment comprising about 0.0005 mg to about 0.05 mg of benzpyrimoxan per ml.Statement 177: The method of any one of Statements 123-159, further comprising applying a larvicidal composition comprising benzpyrimoxan to a breeding environment to cause larvae or population of larvae to contact a composition or breeding aqueous environment comprising about 0.001 mg to about 0.01 mg of benzpyrimoxan per ml.Statement 178: The method of any of Statements 126-177, wherein the larvicidal composition further comprises one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen, temephos, and any combination thereof.Statement 179: The method of any of Statements 126-178, wherein the larvicidal composition further comprises one or more further larvicides selected from the group consisting of Bacillus thuringiensis israelensis, Bacillus sphaericus, and any combination thereof.Statement 180: The method according to any of Statements 126-179, wherein the larvicidal composition further comprises one or more further larvicides from the benzylurea family.Statement 181: The method of any of Statements 126-180, wherein the larvicidal composition further comprises 2,6-difluorobenzylurea.Statement 182: The method of any of Statements 126-181, wherein the larvicidal composition further comprises one or more mineral oils and / or monomolecular films.Statement 183: The method of any of Statements 126-178 wherein the larvicidal composition excludes or does not contain a larvicide from the benzylurea family.Statement 184: The method of any one of Statements 126-178 wherein the larvicidal composition excludes or does not contain 2,6-difluorobenzylurea.Statement 185: The method of any of Statements 126-177, wherein the larvicidal composition excludes or does not contain one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen, and temephos.Statement 186: The method of any one of Statements 126-178 wherein the larvicidal composition excludes or does not contain Bacillus thuringiensis israelensisand / or Bacillus sphaericus.Statement 187: The method of any of Statements 126-186, wherein the larvicidal composition is in the form of a formulation selected from the group consisting of an emulsifiable concentrate (EK), an emulsion in water (EW), a suspension concentrate (SK), a suspoemulsion (SE), a flowable concentrate (FK), a wettable powder (BP), a soluble liquid concentrate (LF), a soluble powder (LP), an ultra-low volume spray (ULV), and any combination thereofStatement 188: The method of any one of Statements 126-186, wherein the larvicidal composition is in the form of a liquid formulation suitable for dilution with water prior to application to a breeding environment or surface thereof.Statement 189: The method of Statement 188 wherein the larvicidal composition is a liquid concentrated larvicidal composition.Statement 190: The method of any of Statements 126-189, wherein the larvicidal composition is a liquid larvicidal composition suitable for spraying with a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 191: The method of any of Statements 188-190, wherein the liquid formulation or liquid larvicide composition comprises water and / or one or more solvents.Statement 192: The method of any one of Statements 126-186, wherein the larvicidal composition is a solid larvicidal composition capable of dissolving or dispersing when wet or in contact with water.Statement 193: The method of any one of Statements 126-192, wherein the larvicidal composition is a solid larvicidal composition in the form of a tablet, a pellet, a briquettes, granules, a wettable granule formulation, a pouch comprising a wettable granule formulation, or any combination thereof.Statement 194: The method of any one of Statements 123-193, wherein the larvae are insect larvae selected from the insect group consisting of mosquitos, rubble mosquitos, sandflies, tsetse flies, chrysops flies (hirschus flies / goldflies), ticks, lice, fleas, midges, predances, triatoinae, and any combination thereof.Statement 195: The method according to any one of Statements 123-194, wherein the larvae are resistant to one or more insecticides.Statement 196: The method of Statement 195, wherein the one or more insecticides are selected from the group consisting of pyrethroids, DDT, carbamates, and organophosphates.Statement 197: The method of any one of Statements 126-196 wherein the larvicidal composition is substantially free of an insecticide or larvicide other than benzpyrimoxane.Statement 198: The method of any one of Statements 123-197, wherein the method is effective to prevent or mitigate transmission of one or more infectious agents or diseases transmitted by diptera or hematophageal insects, wherein the one or more infectious agents or diseases is optionally selected from the group consisting of African Trypanosomiasis (sleep disorder), filariosis, onchocercosis, loniasis (African eyeworm), leishmaniasis, leishmania, trypanosoma, onchocerca volvulus, loa loa, wucherio bancrosti, Brugia malayi, Brugia timori, and trypanosomes.Statement 199: The method of any of Statements 125-198, wherein the incubation environment is a incubation trap for dipteran or hematophageal insects.Statement 200: The method of any one of Statements 123-199, further comprising introducing a larvicidal composition comprising benzopyrimoxan into a reservoir of a breeder trap for diptera or hematophageal insects.Statement 201: The method of any one of Statements 123-199, further comprising causing a larvicidal composition comprising benzopyrimoxan to be placed in a reservoir of a breeder trap for diptera or hematophageal insects.Statement 202: The method of any one of Statements 123-201, further comprising loading a larvicidal composition comprising benzopyrimoxan into a reservoir of a breeder trap for diptera or hematophageal insects.Statement 203: The method according to any of Statements 199-202, wherein the breeder trap is for use in an external environment, wherein the breeder trap comprises a means for receiving a dipteran or hematophageal insect.Statement 204: The method of any of Statements 199-203, wherein the gross trap comprises a means for attracting a diptera or hematophageal insect.Statement 205: The method according to any of Statements 199-204, wherein the gross trap comprises a means for holding water.Statement 206: The method of Statement 205, wherein the blanket trap comprises a reservoir capable of containing and containing water.Statement 207: The method of Statement 205 or Statement 206, wherein the gross trap comprises a means for receiving and containing rainwater in the reservoir or a means for holding water.Statement 208: The method of Statement 205 or Statement 206, wherein the breeder trap further comprises a means for attracting one or more breeding diptera or hematophageal insects.Statement 209: The method of Statement 208, wherein the means for attracting one or more firefly diptera or hematophageal insects comprises one or more chemical or biological attractants.Statement 210: A larvicidal composition for killing larvae of diptera or hematophageal insects, wherein the larvicidal composition comprises a pesticidally effective amount of benzpyrimoxan or a salt, solute, hydrate or solvate thereof.Statement 211: The larvicidal composition of Statement 210, wherein the larvicidal composition comprises a larvicidally effective amount of benzopyrimoxane.Statement 212: The larvicidal composition of Statement 210 or Statement 211, wherein the larvicidal composition is capable of killing at least 90% of larvae contacted with the larvicidal composition.Statement 213: The larvicidal composition of Statement 210 or Statement 211, wherein the larvicidal composition is capable of killing at least 95% of the larvae contacted with the larvicidal composition.Statement 214: The larvicidal composition of Statement 210 or Statement 211, wherein the larvicidal composition is capable of preventing at least 90% of the larvae contacted with the larvicidal composition from depupping or otherwise forming an adult insect.Statement 215: The larvicidal composition of Statement 210 or Statement 211, wherein the larvicidal composition is capable of preventing at least 95% of the larvae contacted with the larvicidal composition from depupping or otherwise forming an adult insect.Statement 216: The larvicidal composition of Statement 210 or Statement 211, wherein the larvicidal composition is capable of causing at least 90% of the larvae contacted with the larvicidal composition to not unpupple or otherwise form an adult insect.Statement 217: The larvicidal composition of Statement 210 or Statement 211, wherein the larvicidal composition is capable of causing at least 95% of the larvae contacted with the larvicidal composition to not unpuppled or otherwise form an adult insect.Statement 218: The larvicidal composition of any of Statements 210-217, wherein the larvicidal composition comprises from about 0.05% to about 65% benzpyrimoxane by weight.Statement 219: The larvicidal composition of any of Statements 210-217, wherein the larvicidal composition comprises from about 1% to about 25% by weight of benzpyrimoxane.Statement 220: The larvicidal composition of any of Statements 210-217, wherein the larvicidal composition comprises about 2% to about 15% by weight of benzpyrimoxane.Statement 221: The larvicidal composition of any of Statements 210-217, wherein the larvicidal composition comprises about 5 wt% to about 15 wt% benzpyrimoxane.Statement 222: The larvicidal composition of any of Statements 210-217, wherein the larvicidal composition comprises less than 10% by weight of benzpyrimoxane.Statement 223: The larvicidal composition according to any of Statements 210-222, wherein the larvicidal composition further comprises one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen, temephos and any combination thereof.Statement 224: The larvicidal composition according to any one of Statements 210-223, wherein the larvicidal composition further comprises one or more further larvicides selected from the group consisting of Bacillus thuringiensis israelensis, Bacillus sphaericus, and any combination thereof.Statement 225: The larvicide composition according to any of Statements 210-224, wherein the larvicide composition further comprises one or more further larvicides from the benzylurea family.Statement 226: The larvicidal composition of any of Statements 210-225, wherein the larvicidal composition further comprises 2,6-difluorobenzylurea.Statement 227: The larvicidal composition of any of Statements 210-226, wherein the larvicidal composition further comprises one or more mineral oils and / or monomolecular films.Statement 228: The larvicidal composition according to any of Statements 210-223, wherein the larvicidal composition excludes or does not contain a larvicide from the benzylurea family.Statement 229: The larvicidal composition of any of Statements 210-223 wherein the larvicidal composition excludes or does not contain 2,6-difluorobenzylurea.Statement 230: The larvicidal composition according to any of Statements 210-222, wherein the larvicidal composition excludes or does not contain one or more further larvicides selected from the group consisting of methoprene, S-methoprene, S-kinoprene, S-hydropen and temephos.Statement 231: The larvicidal composition according to any of Statements 210-223, wherein the larvicidal composition excludes or does not contain Bacillus thuringiensis israelensis and / or Bacillus sphaericus.Statement 232: The larvicidal composition of any of Statements 210-231, wherein the larvicidal composition is in the form of a formulation selected from the group consisting of an emulsifiable concentrate (EK), an emulsion-in-water (EW), a suspension concentrate (SK), a suspoemulsion (SE), a flowable concentrate (FK), a wettable powder (BP), a soluble liquid concentrate (LF), a soluble powder (LP), an ultra-low volume spray (ULV), and any combination thereof.Statement 233: The larvicidal composition of any of Statements 210-231, wherein the larvicidal composition is in the form of a liquid formulation suitable for dilution with water prior to application to a breeding environment or surface thereof.Statement 234: The larvicidal composition of Statement 233, wherein the larvicidal composition is a liquid concentrated larvicidal composition.Statement 235: The larvicide composition of any of Statements 210-231, wherein the larvicide composition is a liquid larvicide composition suitable for spraying with a backpack sprayer, a truck-mounted sprayer, a boat-mounted sprayer, a drone-mounted sprayer, or an aircraft-mounted sprayer.Statement 236: The larvicidal composition of any of Statements 233-235, wherein the liquid formulation or liquid larvicidal composition comprises water and / or one or more solvents.Statement 237: The larvicidal composition of any of Statements 210-231, wherein the larvicidal composition is a solid larvicidal composition capable of dissolving or dispersing when wet or contacting water.Statement 238: The larvicidal composition of any of Statements 210-231 and 237, wherein the larvicidal composition is a solid larvicidal composition in the form of a tablet, a pellet, a briquet, a granule, a wettable granule formulation, a pouch comprising a wettable granule formulation, or any combination thereof.Statement 239: The larvicidal composition of any of Statements 210-238, wherein the larvae are insect larvae selected from the group of insects consisting of mosquitos, rubble mosquitos, sand flies, tsetse flies, chrysops flies (hirsch flies / gold flies), ticks, lice, fleas, midges, predances, triatoniae, and any combination thereof.Statement 240: The larvicidal composition of any one of Statements 210-239 wherein the larvae are resistant to one or more insecticides.Item 241: The larvicidal composition of Item 240, wherein the one or more insecticides are selected from the group consisting of pyrethroids, DDT, carbamates, and organophosphates.Statement 242: The larvicidal composition of any of Statements 210-241, wherein the larvicidal composition is substantially free of an insecticide or larvicide other than benzpyrimoxane.Statement 243: A mosquito rublet comprising a reservoir configured to hold or contain water and capable of holding one or more female mosquitos; wherein the reservoir is further capable of holding a larvicidal composition according to any of Statements 88-122.Statement 244: The mosquito rublet according to statement 243, further comprising a larvicidal composition according to any of statements 88-122, wherein the larvicidal composition is disposed in the reservoir of the mosquito rublet.Statement 245: The mosquito rublet trap of Statement 243 or Statement 244, wherein the reservoir is further capable of receiving and collecting rainwater.Statement 246: The mosquito rublet according to any of Statements 243-245, further comprising a means for attracting one or more female mosquitos.Statement 247: The mosquito rublet trap of Statement 246, wherein the means for attracting one or more female mosquitos comprises one or more chemical or biological attractants.Statement 248: A breeder trap for diptera or hematophage insects comprising a breeder compartment configured to contain one or more breeder diptera or hematophage insects; wherein the breeder compartment is further capable of containing a larvicidal composition according to any one of Statements 210-242.Statement 249: The diptera or hematophage insect breeder of Statement 248, further comprising a larvicidal composition of any one of Statements 210-242, wherein the larvicidal composition is disposed in the breeder compartment of the diptera or hematophage insect breeder.Statement 250: The broadleaf trap for diptera or hematophage insects of any one of Statements 248 or 249, further comprising a means for attracting one or more firefly diptera or hematophage insects.Statement 251: The broadleaf trap for diptera or hematophage insects of Statement 250, wherein the means for attracting one or more firefly diptera or hematophage insects comprises one or more chemical or biological attractants.Statement 252: The breeder trap for diptera or hematophage insects according to statement 251, wherein the means for attracting one or more breeding diptera or hematophage insects is located near the breeder compartment.Statement 253: The breeder trap for diptera or hematophage insects according to Statement 251, wherein the means for attracting one or more breeding diptera or hematophage insects is located in the breeder compartment.

Claims

A method of killing mosquito larvae, the method comprising contacting mosquito larvae with a pesticidally effective amount of benzopyrimoxane or a salt, solute, hydrate or solvate thereof.The method of claim 1, wherein contacting mosquito larvae with a pesticidally effective amount of benzopyrimoxan comprises treating a mosquito breeding environment with a larvicidal composition comprising benzopyrimoxan or a salt, solute, hydrate or solvate thereof.The method of claim 2, wherein treating a mosquito breeding environment with a larvicidal composition comprises spraying a liquid larvicidal composition into or onto a surface of the mosquito breeding environment.The method of claim 2, wherein treating a mosquito breeding environment with a larvicidal composition comprises depositing or applying a solid larvicidal composition into or to a surface of the mosquito breeding environment; wherein the solid larvicidal composition is capable of dissolving or dispersing when wet or contacting water.The method of claim 4, wherein the solid larvicide composition comprises a tablet, a pellet, a briquettes, a granules, a wettable granule formulation, a sachet comprising a wettable granule formulation, or a combination thereof.The method of any one of claims 2 to 5, wherein the mosquito breeding environment is selected from the group consisting of an environment containing or comprising one or more mosquito larvae, an environment in which mosquitos can deposit or brute eggs, a surface or container likely to absorb or wet water, and a standing body of water.The method of any one of claims 2 to 6, wherein the mosquito breeding environment is selected from the group consisting of rinnsteins, cisterns, water troughs for livestock, ponds for livestock, water locations, water storage containers, buckets, rain barrels, fountains, gutters, downcomers, non-chlorinated swimming pools, pool covers that collect water, tires, tree cavities, open water, standing water, still water, running water, small rivers, breds, gulys, and planting vessels or translators.The method of any one of claims 2 to 7, wherein the larvicidal composition is capable of killing at least 95% of mosquito larvae contacted with the larvicidal composition, or is capable of preventing at least 95% of mosquito larvae contacted with the larvicidal composition from depupping or otherwise forming an adult mosquito.The method of any one of claims 2 to 8, wherein the larvicidal composition comprises about 0.05% to about 65% by weight of benzpyrimoxane.The method of any one of claims 2 to 9, further comprising applying benzpyrimoxan to a mosquito breeding environment at an application rate of about 1 g / ha to about 1000 g / ha of active agent.The method of any one of claims 2 to 10, wherein the larvicidal composition is substantially free of an insecticide or larvicide other than benzpyrimoxan and the mosquito larvae are resistant to one or more insecticides.The method of any one of claims 1 to 11, wherein the method is effective for preventing or attenuating transmission of one or more mosquito-transmitted diseases to a human or animal who is / are attending a vector control area in which the method is applied, wherein the one or more mosquito-transmitted diseases are selected from the group consisting of malaria, yellow fever, dengue fever, Zika virus, west nile virus, chikungunya virus, eastern equine encephalitis virus, Japanese encephalitis virus, La-crosse encephalitis and St. Louis encephalitis.A larvicidal composition for use in killing mosquito larvae, wherein the larvicidal composition comprises a pesticidally effective amount of benzopyrimoxan or a salt, solute, hydrate or solvate thereof.The larvicidal composition of claim 13, wherein the larvicidal composition is substantially free of an insecticide or larvicide other than benzpyrimoxane.A mosquito rublet comprising: a reservoir configured to hold or contain water and capable of holding one or more female mosquitos; wherein the reservoir is further capable of holding a larvicidal composition comprising a pesticidally effective amount of benzopyrimoxan or a salt, solute, hydrate or solvate thereof.

Images