Transmission device, analysis device, method for manufacturing a transmission device and method for operating an analysis device

Abstract

The invention relates to a transmission device (110) for transmitting the movement of an actuator of an analytical device to a cartridge (105) containing a fluid. The transmission device (110) comprises a plate (410), at least one channel (415), a flexible membrane (400), and another flexible membrane (405). The plate (410) has a top surface (500) and a bottom surface (505) opposite the top surface (500). The at least one channel (415) is arranged in the plate (410), the channel (415) forming a first channel section (510) adjacent to the top surface (500) and a second channel section (515) adjacent to the bottom surface (505). A fluid (520) is arranged in the channel (415). The flexible membrane (400) is arranged on the top (500) of the plate (410) and seals at least the first channel section (510) in a fluid-tight manner.The further flexible membrane (405) is arranged on the underside (505) of the plate (410) and seals at least the second channel section (515) in a fluid-tight manner.

Description

State of the art

[0001] The invention relates to a transmission device, an analysis device, a method for manufacturing a transmission device, and a method for operating an analysis device according to the preamble of the independent claims. The present invention also relates to a computer program.

[0002] Cartridges used for molecular diagnostics are designed as three- to four-layer sandwich structures, consisting of a fluid layer, a separating membrane, a pneumatic layer, and a further, often two-layer, sealing film. These layers are functional and designed to carry out the reaction processes. Channels within the pneumatic layer form communication channels with the sealing film, primarily used to actuate pump and valve elements on the cartridge via pressurization. The fluid layer contains the fluidic components, such as channels, pumps, and valves, through which the liquids required for the respective analysis flow and are conveyed.The separating membrane ensures airtightness and fluid tightness by sealing off the respective communication channels in the pneumatic and fluid layers; secondly, when deflected, the membrane displaces the fluid, creating the pumping effect and moving the fluid within the fluid layer, in whose channels and chambers the biochemical reaction takes place.

[0003] Secondly, the deflection state controls the valve status, i.e., open or closed. Disclosure of the invention

[0004] Against this background, the approach presented here introduces a transmission device, an analysis device, a method for manufacturing a transmission device, and a method for operating an analysis device, as well as devices that utilize these methods, and finally a corresponding computer program according to the main claims. Advantageous further developments and improvements of the device specified in the independent claim are possible through the measures listed in the dependent claims.

[0005] The advantages achievable with the approach presented here consist in particular of creating a transmission device that can reliably transmit a movement of an actuator to a cartridge.

[0006] A transmission device for transferring the movement of an actuator of an analytical device to a cartridge containing a fluid is presented. The transmission device comprises a plate, at least one channel, a flexible membrane, and another flexible membrane. The plate has a top surface and a bottom surface opposite the top surface. The at least one channel is arranged in the plate, forming a first channel section adjacent to the top surface and a second channel section adjacent to the bottom surface. A fluid is arranged in the channel. The flexible membrane is arranged on the top surface of the plate and seals at least the first channel section in a fluid-tight manner. The second flexible membrane is arranged on the bottom surface of the plate and seals at least the second channel section in a fluid-tight manner.

[0007] In this context, the transmission of movement refers in particular to the transmission of a mechanical force from the actuator to the cartridge.

[0008] The transfer device can, for example, be designed as part of an analytical device that can be used for research or diagnostic purposes. The analytical device can be a compact instrument for molecular diagnostics. The cartridge can be a known lab-on-a-chip cartridge, which can be used, for example, to analyze a patient sample as a fluid. For this purpose, the cartridge can include a microfluidic network for processing fluids. In a preferred embodiment, the cartridge can be fully or at least partially inserted into the transfer device to enable the fluid to be analyzed using the analytical device. The transfer device can also be referred to as an intermediate plate and / or passive plate.The approach presented here can therefore also be understood as a passive plate for cartridge actuation by actuators in an analysis device, which can also be called an analyzer.

[0009] The flexible membrane can be pulled out of the intermediate plate when the actuator is retracted, allowing fluid to flow within the cartridge, and pushed back into the intermediate plate when the actuator is extended, thus blocking fluid flow within the cartridge. The membranes can exhibit high tear resistance and elongation, and can be made of an elastomer, for example, and deform reversibly. Examples of suitable materials for this purpose include nitrile rubber (NBR), ethylene propylene diene monomer (EPDM), and thermoplastic polyurethane (TPU).

[0010] The approach presented here eliminates the need for pneumatics as a process medium in the analyzer, thereby realizing further cost savings by eliminating necessary system components such as pumps, pressure sensors, pneumatic tanks, and manifolds. In current analyzer designs, pneumatics are used to actively switch valves and fluid or pump chambers (filling and emptying). By switching to, for example, electrically driven actuators located within the analyzer or the transmission unit (which is part of the analyzer), pneumatics can be eliminated. In addition to the aforementioned cost savings, this also eliminates a potential source of errors during processing, such as leaks at the cartridge-manifold interface or leaks within the analyzer system itself.Additionally, the noise level of the device during operation can be reduced, which is determined, for example, by the starting of the pumps, which are eliminated in the approach presented here.

[0011] The channel sections can be arranged laterally offset from one another. Additionally or alternatively, the fluid in the channel can be a liquid, in particular water, glycerin, or oil. The oil could, for example, be hydraulic oil. Additionally or alternatively, the transmission device can have a further channel, which may be arranged in the intermediate plate. This further channel can form a further first channel section adjacent to the top and a further second channel section adjacent to the bottom. Another fluid can be arranged in this further channel, with the diaphragm being able to seal the further first channel section fluid-tight, and the further diaphragm being able to seal the further second channel section fluid-tight. The channels can be fluidically separated from one another. It is also conceivable that, in addition to the channel and the further channel, other channels may be provided in the transmission device.These other channels can, for example, be designed analogously to the channel and / or the other channel. It is also conceivable that the channel, the other channel, and / or the other channels are each designed differently from one another without necessarily hindering the functionality of the approach presented here.

[0012] The membrane can be thicker in the area of ​​the first channel section than outside of it. Additionally or alternatively, the second membrane can be thicker in the area of ​​the second channel section than outside of it. This allows for a very simple adjustment of the pressure or force transmission through the appropriate design of the membranes.

[0013] The first channel section can be wider than the second channel section, or the channel sections can have the same width.

[0014] For example, if the effective surface area of ​​the second channel section is doubled, twice the effective force can be generated on the cartridge. If the first channel section is wider than the second, a travel distance of 1000 micrometers on the cartridge can be achieved.

[0015] The transmission device may include a coupling element, which can be arranged on the membrane. The coupling element can be configured to couple the transmission device to the actuator of the analysis device in a positive-locking manner and additionally or alternatively in a force-locking manner. Additionally or alternatively, the transmission device may include a receiving element, which can be arranged on the other membrane. The receiving element can be configured to couple the transmission device to the cartridge in a positive-locking manner and additionally or alternatively in a force-locking manner. Connections based on the lock-and-key principle can be established between the transmission device and the actuator using the coupling element. Connections based on the lock-and-key principle can be established between the transmission device and the cartridge using the receiving element.

[0016] The coupling element can be shaped as an end piece, which may have protrusions and, additionally or alternatively, points for a positive-locking and, additionally or alternatively, a force-locking connection with the actuator of the analysis device. During clamping or insertion, the coupling element can then establish the connection between the cartridge and the transmission device according to the lock-and-key principle, allowing both pulling and pushing movements to be performed. The connection can be released again during unclamping, for example, by applying increased release force.

[0017] The transmission device can have a sealing element that may be arranged on the diaphragm. Additionally or alternatively, the transmission device can have a further sealing element that may be arranged on the second diaphragm. In particular, the sealing element can be arranged in the region of the first channel section on a side opposite the diaphragm. Additionally or alternatively, the further sealing element can be arranged in the region of the second channel section on or in the second diaphragm opposite the first diaphragm. The sealing elements can be arranged circumferentially around the channel sections and can be, for example, O-rings or sealing mats; or designed according to the suction cup principle.

[0018] An analytical device for analyzing a fluid arranged in a cartridge comprises an embodiment of a transmission device described herein and at least one actuator. The actuator is configured to act on the diaphragm of the transmission device, in particular mechanically, specifically to press in the diaphragm in the region of the first channel section and additionally or alternatively to pull it out. The actuator can be, for example, an electromagnetic actuator, an electrodynamic actuator, a shape memory actuator, a piezoelectric actuator, a thermomechanical actuator, or a magnetostrictive actuator. The analytical device can have a plurality of actuators.

[0019] The transmission device can be removable and additionally or alternatively replaceable.

[0020] The analysis device may comprise a cartridge. The transmission device may be coupling to the cartridge, in particular wherein the cartridge may be detachable from the transmission device. The cartridge may have a coupling element which may be configured to receive the receiving element of the transmission device in a form-fitting and / or force-fitting and / or detachable manner. Additionally, the cartridge may have a flexible membrane on which the coupling element may be arranged. The membrane may be pressed into the cartridge in a locked state to block the flow of fluid in a channel of the cartridge and be withdrawn from the cartridge in a released state to allow the flow of fluid in the channel within the cartridge.

[0021] A method for manufacturing an embodiment of a transmission device mentioned herein comprises a provisioning step, an insertion step, and an application step. In the provisioning step, the plate with the channel, the membrane, and the additional membrane are provided. In the insertion step, the fluid is introduced into the channel. In the application step, the membrane is applied to the top of the plate and the additional membrane to the bottom of the plate to manufacture the transmission device.

[0022] A method for operating an embodiment of an analysis device mentioned herein comprises an activation step. In the activation step, the actuator is activated to act on the diaphragm of the transmission device, in particular mechanically, specifically to press in the diaphragm in the region of the first channel section and additionally or alternatively to pull it out.

[0023] The approach presented here further provides a device designed to perform, control, or implement a step of a variant of the method presented here within a corresponding setup. This embodiment of the invention, in the form of a device, also allows the underlying problem to be solved quickly and efficiently.

[0024] For this purpose, the device may have at least one processing unit for processing signals or data, at least one storage unit for storing signals or data, at least one interface to a sensor or actuator for reading sensor signals from the sensor or for outputting data or control signals to the actuator, and / or at least one communication interface for reading or outputting data embedded in a communication protocol. The processing unit may, for example, be a signal processor, a microcontroller, or the like, and the storage unit may be flash memory or a magnetic storage unit.The communication interface can be configured to read or output data wirelessly and / or via wired connections, whereby a communication interface that can read or output wired data can, for example, read this data electrically or optically from or output it into a corresponding data transmission line.

[0025] In this context, a device can be understood as an electrical device that processes sensor signals and outputs control and / or data signals accordingly. The device may have an interface, which can be implemented in hardware and / or software. In the case of a hardware-based interface, the interfaces can, for example, be part of a so-called system ASIC, which incorporates various functions of the device. However, it is also possible that the interfaces are separate integrated circuits or consist at least partially of discrete components. In the case of a software-based interface, the interfaces can be software modules, which, for example, are present on a microcontroller alongside other software modules.

[0026] Also advantageous is a computer program product or computer program with program code that can be stored on a machine-readable carrier or storage medium such as a semiconductor memory, a hard disk memory or an optical memory and is used to carry out, implement and / or control the steps of the method according to one of the embodiments described above, in particular if the program product or program is executed on a computer or device.

[0027] Examples of the approach presented here are shown in the drawings and explained in more detail in the following description. It shows: Fig. 1 a schematic representation of an embodiment of an analysis device; Fig. 2 a schematic representation of an exemplary embodiment of an analysis device; Fig. 3 a schematic representation of an exemplary embodiment of an analysis device; Fig. 4 a schematic representation of an embodiment of an analysis device with intermediate plate / transmission device and cartridge; Fig. 5 a schematic representation of an embodiment of a transmission device / intermediate plate; Fig. 6 a schematic representation of an embodiment of a transmission device / intermediate plate; Fig. 7 a schematic representation of an embodiment of a transmission device / intermediate plate; Fig. 8 a schematic representation of an embodiment of a transmission device; Fig. 9 a schematic representation of an embodiment of a transmission device / intermediate plate; Fig. 10 a schematic representation of an embodiment of a transmission device / intermediate plate; Fig. 11 a flowchart of an embodiment of a method for manufacturing a transmission device; Fig. 12 a flowchart of an embodiment of a method for operating an analysis device; Fig. 13 a block diagram of an embodiment of a device for manufacturing a transmission device; and Fig. 14 a block diagram of an exemplary embodiment of a device for operating an analysis device.

[0028] In the following description of favorable embodiments of the present invention, the same or similar reference numerals are used for the elements shown in the various figures and acting similarly, without repeating these elements.

[0029] Fig. Figure 1 shows a schematic representation of an embodiment of an analysis device 100. The analysis device 100 comprises a transmission device 110 and at least one actuator 115. Optionally, the analysis device 100 comprises a cartridge 105.

[0030] The analysis device 100 is designed to analyze a fluid in the cartridge 105. For this purpose, the cartridge 105 is inserted into the analysis device 100. The analysis device 100 includes, for example, the transfer device 110, which can also be referred to as an intermediate plate and is preferably designed to accommodate the cartridge 105.

[0031] For example, the actuator 115 is arranged in the analysis device 100 such that it can be contacted with a top surface of the transmission device 110. The actuator 115 is designed to act on the transmission device 110. More precisely, the actuator 115 can be moved into an extended state and a retracted state. The transmission device 110 is designed to transmit the movement of the actuator 115 to the cartridge 105.

[0032] In an operational state, the cartridge 105 is, for example, manually inserted into the analysis device 100. The analysis device 100 has an opening for this purpose. The cartridge 105 then makes contact with the transmission device 110, as shown and described in more detail in the following figures, which are only examples of this.

[0033] Instead of using an "active" intermediate plate with, for example, electromagnetic actuators to execute fluidic processes on the cartridge, it is proposed to utilize actuators integrated into the device and to communicate strokes / movements specified by the analyzer to the cartridge via a passive intermediate plate. The actuators can be located at different positions in the analyzer and on the cartridge (su), which offers a significant advantage in terms of cartridge design flexibility. The intermediate plate can thus be viewed as a fluidic transmitter and / or translator, as force and stroke reductions are also possible. The intermediate plate communicates the actuator movements to the specific cartridge position. Furthermore, by controlling multiple analyzer actuators and using appropriately designed channel connections on the intermediate plate (e.g., Y and T connections), for example...Larger strokes can be achieved by having multiple analyzer actuators act on a common cartridge-side pressure chamber. This allows the stroke to be increased (with simultaneous actuation) or switched in stages (with sequential actuation).

[0034] Fig. Figure 2 shows a schematic representation of an embodiment of an analysis device 100. The analysis device 100 is similar to or corresponds to the analysis device from Fig. 1. More precisely, a section of the analysis device 100 is shown in a side view. In other words, it shows Fig. 2 a side view of an actuator array in the analyzer 100.

[0035] According to one embodiment, the analysis device 100 has a plurality of actuators 115, 200, 205; here, only three actuators 115, 200, 205 are shown by way of example. The actuators 115, 200, 205 are, for example, identically shaped, so that for the sake of explanation only actuator 115 is described.

[0036] The actuator 115 is arranged on the analysis device 100 and is designed to retract and extend. The directions in which the actuator 115 moves are indicated by means of a double arrow 210, but only by way of example.

[0037] The actuator 115, for example, has an actuating element 215 which is designed to contact the transmission device in a positive-locking and / or force-locking manner.

[0038] Fig. Figure 3 shows a schematic representation of an embodiment of an analysis device 100. The analysis device 100 is similar to or corresponds to the analysis device from Fig. 2, except that a top view is shown. In other words, it shows Fig. 3 a top view of an actuator array in the analyzer 100.

[0039] The analysis device 100, for example, has twelve actuators 115, 200, 205. According to one embodiment, one or more actuators 115 can be coupled to the transmission device.

[0040] In other words, it shows Fig. 2 and / or Fig. Three embodiments for using multiple actuators 115, 200, 205 in an array configuration. The array is located in the analysis device 100, which can also be referred to as the analyzer, wherein the actuators 115, 200, 205, for example, perform electrically actuated strokes. These are, for example, electromagnetic actuators, electrodynamic actuators, shape memory actuators, piezoelectric actuators, thermomechanical actuators, magnetostrictive actuators, or other actuators such as thermobimetals, strain elements, etc., which perform a movement when a voltage or a magnetic field is applied. The movement occurs in one or both directions, that is, the actuating element 215, which can also be referred to as a plunger, is retractable and / or extendable. This movement is communicated to the cartridge via the transmission device, which can also be referred to as a passive intermediate plate.

[0041] Fig. Figure 4 shows a schematic representation of an embodiment of an analysis device 100. The analysis device 100 is similar to or corresponds to the analysis device from Fig. 1.

[0042] Shown is a combined view of the analysis device 100, showing a top view of the actuators 115, 200, 205, a side view of the transmission device 110, and a bottom view of the cartridge 105. In other words, it shows Fig. 4 the transmission device 110 in section, as well as the cartridge and the analysis device 100 in an unfolded view.

[0043] The analysis device 100 has, for example, twelve actuators 115, 200, 205. The transmission device 110 has a diaphragm 400, another diaphragm 405, a plate 410, and at least one channel 415. According to one embodiment, the transmission device 110 has three channels 415, 420, 425. The diaphragm 400 is arranged on a top surface of the plate 410 and is, for example, welded to the top surface, while the other diaphragm 405 is arranged on a bottom surface opposite the top surface and is, for example, welded to the bottom surface. The channels 415, 420, 425 are arranged in the plate 410. The channel 415 connects, for example, the actuator 115 to a cartridge channel 430.

[0044] According to one embodiment, at least one coupling element 430 is arranged on the membrane 400 and, for example, two sealing elements 435, 440 are arranged on the further membrane 405. The coupling element 430 and the sealing element 435 are described and illustrated in more detail in the following figures.

[0045] The transmission device 110 is designed to transmit a movement from at least one of the actuators 115, 200, 205 to the cartridge 105. The following figures describe and illustrate the transmission device 110 in more detail.

[0046] In other words, it shows Fig. 4 the transmission device 110 as a purely passive connecting element, more precisely as a passive intermediate plate, hydraulically sealed.

[0047] Actuators 115, 200, and 205 are, for example, arranged in the analysis device 100 and electrically connected to it. The transmission device 110 is, for example, passively configured, connecting the cartridge-specific actuating elements (valves and pumps) on one side and actuators 115, 200, and 205 on the side of the analysis device 100. The advantage of this configuration is that the transmission device 110 exists and operates purely as a connecting element, thus requiring no external power supply.

[0048] According to the embodiment shown here, all actuators 115, 200, 205 are arranged in the analysis device 100 and, for example, configured in a space-optimized array arrangement. The transmission device 110 has a solid base body containing the channels 415, 420, 425, which serve as connecting channels between the analysis actuators located on the top and the cartridge actuators located on the bottom. The transmission device 110 can be, for example, a machined part, a bonded / soldered layered construction, a casting, or a 3D-printed part. The transmission device 110 is fluidically sealed at the top and bottom by the membranes 400, 405, for example, by welding, so that no medium can escape over its service life. The membranes 400, 405 are, for example, made of elastomer. Filling can be carried out, for example, by...Air and bubble-free through prior evacuation.

[0049] Water or oil, for example, can be used as the transmission and working medium. Fluidic transmission eliminates the location dependency of the actuators and the associated limitations in implementation. Additionally, the actuator force can be scaled by adjusting the bore diameters on the top and bottom of the transmission device 110. For example, if the bore diameter of a communication channel on the top (actuator side) is half the size of the bore diameter on the bottom (cartridge side), the sealing force at the cartridge valve can be quadrupled. This allows for specific adjustment of the sealing forces or enables miniaturization of the actuator array on the analyzer side.

[0050] In other words, it shows Fig. Figure 4 shows the different valve chambers and pump chambers of the cartridge 105 and the actuators 115, 200, 205 of the analysis device 100 in an unfolded view. The transmission device 110, which connects the different positions via fluidic channels 415, 420, 425, is located in the section between them.

[0051] Fig. Figure 5 shows a schematic representation of an embodiment of a transmission device 110. The transmission device 110 is similar to or corresponds to the transmission device from one of the figures described above, for example. Fig. 4.

[0052] The transmission device 110 comprises the plate 410, at least one channel 415, the flexible membrane 400, and the additional flexible membrane 405. The plate 410 has a top surface 500 and a bottom surface 505 opposite the top surface 500. The channel 415, which can also be referred to as the fluid communication channel, is arranged in the plate 410 and forms a first channel section 510 and a second channel section 515. The first channel section 510 adjoins the top surface 500 of the plate 410, and the second channel section 515 adjoins the bottom surface 505 of the plate 410. According to one embodiment, the channel sections 510 and 515 are arranged laterally offset from each other. The channel sections 510 and 515, for example, form an identical width with respect to the orientation of the bottom surface 505 and / or the top surface 500.

[0053] A fluid 520 is arranged in channel 415, where the fluid 520 is, for example, a liquid such as water, glycerin or oil.

[0054] The flexible membrane 400, which can also be referred to as the sealing membrane, is arranged on the upper surface 500 of the plate 410 and seals at least the first channel section 510 in a fluid-tight manner. The second flexible membrane 400 is arranged on the lower surface 505 of the plate 410 and seals at least the second channel section 515 in a fluid-tight manner. According to one embodiment, the membrane 400 is thicker than the second membrane 405.

[0055] The transmission device 110, for example, includes the coupling element 430, which is arranged on the membrane 400. According to one embodiment, the coupling element 430 is arranged in the region of the first channel section 510 and extends perpendicularly away from the membrane 400. The coupling element 430 is designed to couple the transmission device 110 to the actuator of the analysis device in a positive-locking and / or force-locking manner. According to one embodiment, the coupling element 430 is shaped as an end piece, wherein the end piece has protrusions and / or points. For example, the protrusions are shaped as a Christmas tree structure.

[0056] According to a further embodiment, the transmission device 110 has a receiving element 525 arranged on the further membrane 405. In one embodiment, the receiving element 525 is arranged in the region of the second channel section 515 and extends perpendicularly away from the further membrane 405. The receiving element 525 is designed to couple with the cartridge 105 in a positive-locking and / or force-locking manner. For this purpose, the receiving element 525 is, for example, shaped like a sleeve, a pocket, or a cup. According to the embodiment shown here, the receiving element 525 is coupled to the cartridge 105, and thus the transmission device 110 is coupled to the cartridge 105.

[0057] The cartridge 105 has a channel 530, which can also be referred to as a fluid channel, wherein a fluid 535 is arranged in and guided in the channel 530.

[0058] The channel 530 has, for example, an inner surface 545 and an outer surface 540 opposite the inner surface 545. A separating web 550, projecting into the channel 530, is arranged on the inner surface 545 (this is merely an example). A membrane 555, for example, is arranged on the outer surface 540. The membrane 555 extends, for example, over the entire length of the outer surface 540 and is flexible. The cartridge 105 has a coupling element 560, which is arranged, for example, on the membrane 555 and extends perpendicularly away from the membrane 555. The coupling element 560 is designed to couple positively and / or force-fit with the receiving element 525 of the transmission device 110. The detachable coupling element 560 can be pulled out of the receiving element 525, for example due to at least partial elasticity of the receiving element 525 and / or the coupling element 560.The receiving element 525 is shown here in a sleeve-shaped form only as an example. Alternatively, the receiving element 525 can be shaped like a pocket or a pot.

[0059] In an operational state, the transmission device 110 is arranged in the analysis device, as is shown, for example, in Fig. Figure 1 shows the analysis device. The analysis device has at least one actuator configured to act on the membrane 400 of the transmission device 110. The coupling element 430 is, for example, coupled to the actuator. The cartridge 105 is, for example, manually inserted into the analysis device, with the coupling element 560 of the cartridge 105 being, for example, coupled to the receiving element 525 of the transmission device 110.

[0060] The actuator is configured to perform a movement, wherein the transmission device 110 is configured to transmit this movement to the cartridge 105.

[0061] The actuator performs, for example, an extension movement and / or a retraction movement. When the actuator extends, it pushes the coupling element 430 of the transmission device 110 in the direction of the first channel section 510. This pushes in the diaphragm 400 in the area of ​​the first channel section 510. The extension movement of the actuator is then transmitted via channel 415 to the second diaphragm 405 in the area of ​​the second channel section 515. The second diaphragm 405 is pushed in the direction of the cartridge 105 in the area of ​​the second channel section 515. In this way, the coupling element 560 of the cartridge 105, or the diaphragm 555 of the cartridge, is pressed against the separating bar 550, thus preventing the flow of fluid 535 in the channel 530 of the cartridge 105.

[0062] For example, when the actuator retracts, it pulls the coupling element 430 of the transmission device 110 away from the first channel section 510. This pulls out the diaphragm 400 in the area of ​​the first channel section 510. The retracting movement of the actuator is transmitted via channel 415 to the second diaphragm 405 in the area of ​​the second channel section 515. The second diaphragm 405 is pressed inwards towards the second channel section 515. In this way, the coupling element 560 of the cartridge 105, or the diaphragm 555 of the cartridge 105, is pulled out and the separating web 550 is released, thus allowing the fluid 535 to flow in the channel 530 of the cartridge 105.

[0063] In other words, the transmission device 110 is tightly welded / sealed from the environment and filled with fluid 515 to form specifically enclosed communication channels. The transmission device 110 itself is designed, for example, as a milled, die-cast, stamped, or (injection-)cast part, or also as a sandwich composite of individual plates which, when assembled, form the enclosed channels. The channel 415 or the fluid-filled channels, see Fig. 4. The fluid cross-sections are chosen to be minimal and, for example, less than 0.5 square millimeters. Thus, the entire transmission device 110 has a thickness of, for example, less than two millimeters. The length of the communication channels depends on the actuator position in the analysis device 100 and the position of the switching valve or pump chamber on the cartridge 105 to be operated. The external dimensions of the transmission device 110 are, for example, on the order of the cartridge 105 and are geometrically defined by the coupling components involved, the actuator array and the cartridge 105 (cartridge layout). The cartridge 105 is between 20 millimeters and 100 millimeters wide, preferably 80 millimeters, and has a length between 100 millimeters and 200 millimeters, preferably 180 millimeters.

[0064] The enclosed fluid 520, which can also be referred to as the working fluid, in the transmission device 110 can be gaseous substances, for example, air, or liquid. To achieve high rigidity and to transmit the actuator's travel on the analyzer side as efficiently as possible, weakly compressible to incompressible fluids should be used. Suitable fluids include, for example, water, glycerin, or hydraulic oils. Force transmissions or reductions relative to the effective area on the actuator side can be achieved by geometrically adapting the active surface acting on the cartridge 105. For example, with a doubled effective area in the region of the first channel section 510, which is also referred to as actuator side A, A can be described as, relative to the second channel section 515, which is also known as cartridge side A K can be described, see Fig. 7, half the effective force and double the stroke can be generated on the cartridge 105. This is achieved, for example, if the channel outlet is designed as a sealing volume, see Fig. 4, or expands conically towards membrane 400 and / or the further membrane 405. For example, the area in contact with membrane 400 and / or the further membrane 405 deviates from the channel cross-section and is, for example, only three square millimeters. The actuator travel distances are also reduced or multiplied according to the same force-amplifying principle. The actuators cover, for example, travel distances between 100 and 1000 micrometers, for example, 500 micrometers. With an area ratio of A A / A K = 2, see Fig. 7, thus a travel distance of 1000 micrometers on the cartridge 105 is achievable. The membrane 400 and / or the further membrane 405 of the transmission device 110, for example, exhibits high tear resistance and elongation. In the working area of ​​the cartridge 105, it exhibits elastic properties and deforms accordingly reversibly. Possible materials that can be used include, for example, nitrile rubber (NBR), ethylene propylene diene monomer rubber (EPDM), or thermoplastic polyurethane (TPU). Extending stroke movements of the actuators can be executed directly by pressing on the cartridge 105 via the transmission device 110. Pulling movements are transmitted from the analyzer side to the transmission device 110, for example, via coupling elements 430 located on the transmission device 110, such as undercut geometries, Christmas tree structures, hook-and-loop structures, or adhesives.To transfer pulling actuator position paths to the cartridge 105, there are two approaches: In the first, a force-controlled coupling, the cartridge 105 can be coupled to the transmission device 110, for example, also via sealing elements, whereby an externally sealed air volume is created between the top of the transmission device 110 and the relevant position on the cartridge 105, see . Fig. 4 and Fig. 9. The sealing required for reducing the pressure is also achieved, for example, by additional sealing elements, such as O-rings, sealing mats, elastomer intermediate layers, see Fig. 8.

[0065] The movement away from the cartridge 105 reduces the pressure in the resulting enclosed volume, causing the diaphragm 555 of the cartridge 105, which can also be described as an elastomer diaphragm, to deform and lift. This lifting movement, for example, opens a fluid channel on the cartridge 105 (the cartridge valve opens) or increases the volume of a pump chamber, thus triggering a suction event. Conversely, when the pressure increases, the actuator's actuator arm extends, compressing the fluid in the enclosed volume. The resulting pressure increase acts on the diaphragm 555, which can also be described as the diaphragm area, either expelling the pump chamber or closing the valve, thereby blocking the fluid flow on the cartridge 105. The combined movement of the actuator arm in and out thus pumps / suctions the medium in the cartridge 105 and switches valves on the cartridge 105 (open / close).By introducing a pneumatic coupling element as described here between transmission device 110 and the cartridge 105, the cartridge 105 can be designed with a conventional two-dimensional membrane 555, unit thickness for example 150 micrometers.

[0066] As an alternative to pneumatic coupling, displacement-controlled couplings are also possible, in which mechanical structures on the transmission device 110 and / or cartridge 105 are conceivable, based on the key-lock principle, interlocking, or latching, which mechanically connect during the clamping process or the insertion of the cartridge. Fig. 5, Fig. 6, Fig. 7, Fig. 8, Fig. 9 to Fig. Figure 10 illustrates various coupling concepts between the transmission device 110 and the cartridge 105. Since the exchange interval of a transmission device 110 is much smaller than that of a cartridge 105, positive-locking connections between the analysis device and the transmission device 110 are preferable, as shown in Figure 10. Fig. 5 shown. The interface between cartridge 105 and transmission device 110, for example, is designed to be both force-fit and form-fit equivalent and is selected with regard to reliability and possible operating conditions, for example temperature fluctuations.

[0067] In a first and second version, the membrane 555, which can also be referred to as a cartridge membrane, is designed with raised structures that represent coupling elements 560, see for example Fig. 5 and / or Fig. 6. During clamping, the connection between cartridge 105 and transmission device 110 is established according to the key-lock principle, allowing both pulling and pushing movements. The connection is released again during unclamping, for example, by applying increased release force. For a third and fourth embodiment, see [reference to relevant section]. Fig. 8 and / or Fig. 9. The connection is realized by creating a pneumatic coupling element. The coupling element is represented by a resulting volume in which the pressure is varied by the actuator movement during processing, leading to the opening and closing of the cartridge valve. The tightness of the volume to the environment is increased by additional sealing elements, such as O-rings, sealing mats, or suction cups, which are attached to the transmission device 110 or the cartridge 105 (see, for example, [reference]). Fig. 8. The advantage of the variants in the Fig. In a fifth variant, the membrane 555 of the cartridge 105 is implemented as a flat, two-dimensional structure, as in the conventional design. Fig. 10. The stiffness of the membranes 400 and 405 on the transmission device 110 is locally increased, for example, by local thickening, for example, to H = 300 micrometers to 750 micrometers, by a factor of 2-5 of the nominal thickness of the membrane 400 and / or the other membrane 405, for example, 150 micrometers, by inserting disc springs, or by inserting highly elastic materials. This allows the restoring forces of the membrane 555 to be designed. The necessary restoring force must be taken into account in the actuator design, i.e., in the analysis device, since it must be overcome during extension.

[0068] Fig. Figure 6 shows a schematic representation of an embodiment of a transmission device 110. The transmission device 110 is similar to or corresponds to the transmission device from [reference missing]. Fig. 5, except that the other membrane 405 is shaped differently.

[0069] More precisely, the additional membrane 405 is formed thicker than the membrane 400, at least twice as thick as the membrane 400, for example. The additional membrane 405 and the receiving element 525 are formed in one piece, with the receiving element 525 extending, for example, over the entire length of the additional membrane 405.

[0070] Fig. Figure 7 shows a schematic representation of an embodiment of a transmission device 110. The transmission device 110 is similar to or corresponds to the transmission device from one of the above-described devices. Fig. 5 to Fig. 6.

[0071] According to one embodiment, the membrane 400 is thicker in the area of ​​the first channel section 510 than outside the first channel section 510.

[0072] The further membrane 405 is designed to contact the membrane 555 of the cartridge 105 in a form-fitting and / or force-fitting manner. The second channel section 515 and a channel section 700 of the cartridge 105 are arranged opposite each other, with the channel section 700 of the cartridge 105 being wider than the second channel section 515 of the transmission device 110. The second channel section 515 is, for example, arranged centrally opposite the channel section 700 of the cartridge 105, such that the separating web 550 is arranged centrally opposite the second channel section 515.

[0073] Fig. Figure 8 shows a schematic representation of an embodiment of a transmission device 110. The transmission device 110 is similar to or corresponds to the transmission device from one of the above-described Fig. 5, Fig. 6 to Fig. 7.

[0074] According to one embodiment, the transmission device 110 has a sealing element 800 and a further sealing element 805. The sealing element 800 is arranged on the diaphragm 400, more precisely in the region of the first channel section 510. The further sealing element 805 is arranged on the second diaphragm 405, more precisely in the region of the second channel section 515.

[0075] According to one embodiment, the sealing elements 800, 805 are arranged around the channel sections 510, 515 and are shaped, for example, as O-rings.

[0076] The sealing element 800 is, for example, arranged on the membrane 400 such that it seals the thickness of the first channel section 510. The further sealing element 805 is, for example, arranged on the further membrane 405 such that it seals channel section 700 of channel 530 of cartridge 105 and the second channel section 515. Channel section 700 of cartridge 105 is, for example, wider than the second channel section 515, which means that the further sealing element 805 forms, for example, a larger radius than the sealing element 800.

[0077] Fig. Figure 9 shows a schematic representation of an embodiment of a transmission device 110. The transmission device 110 is similar to or corresponds to the transmission device from one of the above-described Fig. 5, Fig. 6, Fig. 7 to Fig. 8.

[0078] More precisely, the transmission device 110 resembles the transmission device from Fig. 8, except that additional sealing elements are omitted and the tightness is achieved by the elastomer membranes present on both sides.

[0079] Fig. Figure 10 shows a schematic representation of an embodiment of a transmission device 110. The transmission device 110 is similar to or corresponds to the transmission device from one of the above-described devices. Fig. 5, Fig. 6, Fig. 7, Fig. 8 to Fig. 9, except that the cartridge is omitted.

[0080] The membrane 400 is thicker in the area of ​​the first channel section 510 than outside of the first channel section 510, and the first channel section 510 is also thicker than the second channel section 515. The further membrane 405 is thicker in the area of ​​the second channel section 515 than outside of the second channel section 515.

[0081] In other words, the diaphragms 400 and 405 exhibit a locally higher diaphragm stiffness to enhance restoring forces.

[0082] Fig. Figure 11 shows a flowchart of an embodiment of a method 1100 for manufacturing a transmission device. The transmission device is similar to or corresponds, for example, to the transmission device from one of the figures described above.

[0083] Method 1100 comprises a provisioning step 1105, a insertion step 1110, and an application step 1115. In provisioning step 1105, the plate with the channel, the membrane, and the additional membrane are provided. In insertion step 1110, the fluid is introduced into the channel. In application step 1115, the membrane is applied to the top of the plate, and the additional membrane is applied to the bottom of the plate to create the transmission device.

[0084] Fig. Figure 12 shows a flowchart of an embodiment of a method 1200 for operating an analysis device. The analysis device is similar to or corresponds, for example, to the analysis device from one of the figures described above.

[0085] Method 1200 comprises an activation step 1205. In activation step 1205, the actuator is activated to act on the diaphragm of the transmission device, in particular to press in the diaphragm in the area of ​​the first channel section and additionally or alternatively to pull it out.

[0086] Fig. Figure 13 shows a block diagram of an exemplary embodiment of a device 1300 for manufacturing a transmission device. The device 1300 is designed to perform the method from Fig. 11 or a similar procedure to target and / or operate.

[0087] The device 1300 comprises a supply unit 1305, a insertion unit 1310, and an application unit 1315. The supply unit 1305 is configured to supply the plate with the channel, the membrane, and the additional membrane. The insertion unit 1310 is configured to introduce the fluid into the channel. The application unit 1315 is configured to apply the membrane to the top of the plate and the additional membrane to the underside of the plate to form the transmission device.

[0088] Fig. Figure 14 shows a block diagram of an exemplary embodiment of a device 1400 for operating an analysis device. The device 1400 is designed to perform the method from Fig. 12 or a similar procedure to target and / or operate.

[0089] For this purpose, the device 1400 has an activation unit 1405 which is configured to activate the actuator to act on the diaphragm of the transmission device, in particular to push in the diaphragm in the area of ​​the first channel section and additionally or alternatively to pull it out.

[0090] If an embodiment includes an “and / or” connection between a first feature and a second feature, this is to be read as meaning that the embodiment according to one embodiment has both the first feature and the second feature, and according to another embodiment either only the first feature or only the second feature.

Claims

[1] Transmission device (110) for transmitting a movement of an actuator (115) of an analysis device (100) to a cartridge (105) containing a fluid, wherein the transmission device (110) has the following features: a plate (410) with a top (500) and a bottom (505) opposite the top (500); at least one channel (415) arranged in the plate (410), wherein the channel (415) forms a first channel section (510) adjoining the top (500) and a second channel section (515) adjoining the bottom (505), and wherein a fluid (520) is arranged in the channel (415); a flexible membrane (400) arranged on the top (500) of the plate (410) and sealing at least the first channel section (510) in a fluid-tight manner; and a further flexible membrane (405) which is arranged on the underside (505) of the plate (410) and seals at least the second channel section (515) in a fluid-tight manner. [2] Transmission device (110) according to claim 1, - wherein the channel sections (510, 515) are arranged laterally offset from each other or opposite each other and / or - wherein the fluid (520) in the channel (415) is a liquid, in particular water, glycerin or oil and / or with a further channel (420) arranged in the plate (410), - wherein the further channel (420) forms a further first channel section adjacent to the top (500) and a further second channel section adjacent to the bottom (505), and wherein a further fluid is arranged in the further channel (420), wherein the membrane (400) closes the further first channel section in a fluid-tight manner and wherein the further membrane (405) closes the further second channel section in a fluid-tight manner, in particular wherein the channel (415) and the further channel (420) are fluidically coupled to each other. [3] Transmission device (110) according to one of the preceding claims, wherein the membrane (400) is formed thicker in the area of ​​the first channel section (510) than outside the first channel section (510) and / or wherein the further membrane (405) is formed thicker in the area of ​​the second channel section (515) than outside the second channel section (515). [4] Transmission device (110) according to one of the preceding claims, wherein the first channel section (510) is wider than the second channel section (515) or wherein the channel sections (510, 515) have an identical width and / or wherein the first channel section (510) and / or the second channel section (515) have the same or different shape, in particular a round, oval or rectangular shape. [5] Transmission device (110) according to one of the preceding claims, comprising a coupling element (430) arranged on the membrane (400) and configured to couple the transmission device (110) to the actuator (115) of the analysis device (100) in a positive-locking and / or force-locking manner and / or to a receiving element (525) arranged on the further membrane (405) and configured to couple the transmission device (110) to the cartridge (105) in a positive-locking and / or force-locking manner. [6] Transmission device (110) according to claim 5, wherein the coupling element (430) is formed as an end piece, the end piece having protrusions and / or points for a positive and / or force-fit connection with the actuator (115) of the analysis device (100). [7] Transmission device (110) according to one of the preceding claims, comprising a sealing element (800) arranged on the membrane (400) and / or a further sealing element (805) arranged on the further membrane (405), in particular wherein the sealing element (800) is arranged in the region of the first channel section (510) and / or wherein the further sealing element (805) is arranged in the region of the second channel section (515). [8] Analysis device (100) for analyzing a fluid arranged in a cartridge (105) comprising a transmission device (110) according to one of the preceding claims and comprising at least one actuator (115) configured to act on the membrane (400) of the transmission device (110), in particular to push in and / or pull out the membrane (400) in the area of ​​the first channel section (510). [9] Analysis device (100) according to claim 8, wherein the transmission device (110) is removable and / or replaceable and / or wherein the analysis device (100) has at least one sealing element (800) to seal an area of ​​a membrane (400) of a transmission device (110) inserted into the analysis device (100) against environmental influences. [10] Analysis device (100) according to one of claims 8 to 9, comprising a cartridge (105), wherein the transmission device (110) is connectable to the cartridge (105), in particular wherein the cartridge (105) is detachable from the transmission device (110). [11] Method (1100) for manufacturing the transmission device (110) according to any one of claims 1 to 7, wherein the method (1100) comprises the following steps: Providing (1105) the plate (410) with the channel (415), the membrane (400) and the further membrane (405); Introducing (1110) the fluid into the channel (415); and Applying (1115) the membrane (400) to the top (500) of the plate (410) and the further membrane (405) to the bottom (505) of the plate (410) to produce the transmission device (110). [12] Method (1200) for operating the analysis device (100) according to any one of claims 8 to 10, wherein the method (1200) comprises the following step: Activating (1200) the actuator (115) to act on the membrane (400) of the transmission device (110), in particular to push in and / or pull out the membrane (400) in the area of ​​the first channel section (510). [13] Device (1300; 1400) configured to perform and / or control the step of the method (1200) according to claim 12 in a corresponding unit and / or to perform and / or control the steps of the method (1100) according to claim 11 in corresponding units. [14] Computer program configured to perform and / or control the step of the method according to claim 12 and / or the steps of the method according to claim 11. [15] Machine-readable storage medium on which the computer program according to claim 14 is stored.

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