ANALYSIS OF MOTION SEQUALIZATIONS USING PRINTED CIRCUITS

Abstract

A process that exhibits: Determining a sequence of tissue movements by one or more computer processors (514) at least partially based on one or more printed circuits within a printed organic component; Activation of the sequence of tissue movements by one or more computer processors (514) by applying external excitation pulses to one or more printed circuits (314-322); Analyzing a signal response from one or more printed circuits by one or more computer processors (514) in response to activation of the sequence of tissue movements; and Generating one or more pressure recommendations by one or more computer processors (514) at least partially based on the analysis of the signal response.

Description

BACKGROUND OF THE INVENTION

[0001] The present invention relates generally to cognitive data processing systems and in particular to machine learning for the analysis of motion sequences using printed circuits within biologically printed organic components.

[0002] In bioprinting processes, organic components are extracted from cells and converted into a printable biological ink. Layers of cells are deposited in carefully calculated patterns to build small tissue areas. Using three-dimensional bioprinting techniques, various organic components can be printed and successfully transplanted into the body.

[0003] In this context, several documents have already been published. For example, document US 2021 / 0071127A1 describes transplanted units of living 3D-printed tissue and electronic circuits, as well as optical systems that interact with body components. This makes it possible to test, measure, monitor, control, repair, replace, or support bodily functions. Furthermore, document US 2021 / 0330864A1 describes a method for creating biosynthetic 3D tissue using a "bioink" containing a multitude of living cells.

[0004] Despite these advances already made, there is still a need to measure elements of a living organism – for example, its internal movements. SUMMARY

[0005] This problem is solved by the subject matter of the independent patent claims. Further details arise from the respective dependent patent claims.

[0006] Aspects of an embodiment of the present invention disclose a method, a computer system, and a computer program product for analyzing motion sequences using printed circuits. The method comprises determining a sequence of operations, at least in part, based on one or more printed circuits within a printed organic component. The method further comprises activating the sequence of operations using external excitation pulses applied to the one or more printed circuits. The method further comprises analyzing a signal response from the one or more printed circuits in response to the activation of the sequence of operations. The method further comprises generating one or more print recommendations, at least in part, based on the analysis of the signal response. BRIEF DESCRIPTION OF THE DRAWINGS Fig. Figure 1 is a functional block diagram illustrating a data processing environment suitable for executing a circuit management program according to an embodiment of the present invention. Fig. Figure 2 is a flowchart showing the work steps of a circuit management program according to an embodiment of the present invention. Fig. Figure 3 is a structural diagram of an arrangement of printed circuits within a biologically printed organic component according to an embodiment of the present invention. Fig. Figure 4 is a flowchart showing the work steps of a circuit management program according to an embodiment of the present invention. Fig. 5 is a block diagram showing the components of a data processing system (e.g., the server computer of Fig. 1) according to an embodiment of the present invention. DETAILED DESCRIPTION

[0007] Embodiments of the present invention assume that, following the transplantation of an artificially produced organic component, a researcher or physician might be interested in further monitoring the health status and biocompatibility of the artificially produced organic component within a body. Embodiments of the present invention further assume that the consistent and continuous monitoring of the process in real time is crucial for a successful transplantation.

[0008] Embodiments of the present invention provide the capability to print multilayer three-dimensional circuits in different layers of artificial cells of a printed organic component during the biological printing process. Embodiments of the present invention further provide the capability to generate a sequence of steps using multilayer printed circuits, which can be used to monitor the performance and biocompatibility of transplanted organic components in a patient.

[0009] Furthermore, the inventor has observed and / or perceived that when printing an organic component using a three-dimensional bioprinting process, circuits can be printed in different layers of artificial cells of a printed organic component, which are self-powered, wherein the printed circuits, after implantation into a body, can generate electrical energy obtained from the movement of artificial and natural tissues and signals for monitoring the performance and compatibility parameters of the printed organic component.

[0010] Furthermore, the inventor has observed and / or perceived that, depending on the type of organic component and a plurality of performance and compatibility parameters to be monitored, an intelligent combination of circuits can be successively printed within different layers of artificial cells of a printed organic component in order to capture the various performance and compatibility parameters for the consistent and permanent monitoring of the printed organic component.

[0011] Furthermore, the inventor has observed and / or perceived that embodiments of the present invention, when printing an organic component using a three-dimensional bioprinting method, provide the ability to determine expected natural movements in the printed organic component and, accordingly, an optimal location within the printed organic component for a printed circuit to generate electrical energy from the natural movement.

[0012] Furthermore, the inventor has observed and / or perceived that a printed circuit can contain one or more piezoelectric chips to generate and provide electrical energy based on the natural movement of tissue in order to send signals to a coupled mobile unit for the consistent and continuous monitoring of the printed organic component.

[0013] An implementation of such embodiments can take a variety of forms, with exemplary implementation details being discussed below with reference to the figures.

[0014] With detailed reference to various embodiments of the invention, Fig. Figure 1 shows a functional block diagram of a distributed data processing environment, reference number 100, suitable for executing a circuit management program according to at least one embodiment of the invention. The term "distributed" as used in this specification describes a computer system comprising several physically distinct units that cooperate as a single computer system. Figure 1 illustrates only one implementation and is not intended to limit the environments in which different embodiments may be implemented. A person skilled in the art can make many changes to the environment shown without deviating from the scope of protection of the invention as set forth in the claims.

[0015] The distributed data processing environment 100 comprises a mobile unit 102, a server computer 104, and a bioprinting unit 108, all interconnected via a network 106. The network 106 can be, for example, a telephone network, a local area network (LAN), a wide area network (WAN) such as the internet, or a combination of all three, and it can include wired, wireless, or fiber optic connections. The network 106 can include one or more wired and / or wireless networks capable of receiving and transmitting data, voice, and / or video signals, including multimedia signals containing voice, data, and video information.In general, the network 106 can be any combination of connections and protocols that support data transmissions between the mobile unit 102, the server computer 104, and the bioprinting unit 108, as well as other (not shown) data processing units within the distributed data processing environment 100. Fig. 1 is intended to be just an example and does not imply any limitation of the architecture for the various embodiments.

[0016] According to one embodiment, the mobile unit 102 can be a laptop computer, a tablet computer, a smartphone, a smartwatch, or any programmable electronic unit capable of exchanging data with various components and units within the distributed data processing environment 100 via the network 106. More generally, the mobile unit 102 can be any programmable electronic unit or combination of programmable electronic units capable of executing machine-readable program instructions and exchanging data with other (not shown) data processing units within the distributed data processing environment 100 via a network such as the network 106. More specifically, the mobile unit 102 is any unit capable of sending and receiving signals, monitoring data, and analyzing response signals.According to another embodiment, the mobile unit 102 can be a sensor or a collection of connected sensors (i.e., a paired smartwatch, a heart monitor, or another wearable electronic device, etc.) capable of sending and receiving signals, monitoring data, and analyzing response signals related to a patient's physical condition. According to another embodiment, the mobile unit 102 can be a tablet computer used by a physician to externally stimulate a printed circuit within a transplanted printed organic component and to monitor various performance and compatibility parameters related to the transplanted printed organic component. According to one embodiment, the mobile unit 102 is capable of exchanging data with the server computer 104 and the bioprinting unit 108.According to one embodiment, the mobile unit 102 includes a user interface 112.

[0017] According to one embodiment, the user interface provides an interface between a user of the mobile unit 102 and the server computer 104. According to one embodiment, the user interface 112 can be a graphical user interface (GUI) or a web user interface (WUI) that can display text, documents, web browser windows, user options, application interfaces, and operating instructions, and includes the information (for example, graphics, text, and sound) that a program displays to a user and the control sequences that the user uses to control the program. According to another embodiment, the user interface 112 can also be mobile application software that provides an interface between a user of the mobile unit 102, the bioprinting unit 108, and the server computer 104.Mobile application software, or an "app," is a computer program that controls the functions on smartphones, tablet computers, smartwatches, and any other mobile devices.

[0018] According to one embodiment, the server computer 104 can be a standalone data processing unit, an administration server, a web server, a mobile data processing unit, or any other electronic unit or data processing system capable of receiving, sending, and processing data. According to other embodiments, the server computer 104 can be a server data processing system that utilizes multiple computers as a single server system, for example, in a cloud computing environment. According to one embodiment, the server computer 104 is a data processing system that utilizes a group of computers and components (e.g., database server computers, application server computers, etc.) that act as a single pool of seamlessly interconnected resources when accessed within the distributed data processing environment 100.The server computer 104 contains a circuit management program 110, which is connected to the server computer 104 for data exchange and enables data transfers between the circuit management program 110, the mobile unit 102, and the bioprinting unit 108. The server computer 104 contains internal and external hardware components, which are described with reference to... Fig. 5 will be shown and described in detail.

[0019] According to one embodiment, the circuit management program 110 is executed on a central server, such as the server computer 104, and can be accessed by one or more mobile units, such as the mobile unit 102 and the bioprinting unit 108, via the network 106. According to another embodiment, the circuit management program 110 can be a program that can be downloaded from the central server or an external provider (not shown) and executed on a mobile unit, such as the mobile unit 102, to control the printing of multilayer circuits during three-dimensional bioprinting processes and to monitor movement sequences of artificial cells in a transplanted printed organic component.According to another embodiment, the circuit management program 110 can be a program that is downloaded from a central server, such as the server computer 104, and installed on one or more mobile units, such as the mobile unit 102. According to yet another embodiment, the circuit management program 110 can be used as a software service provided by an external cloud provider (not shown). According to yet another embodiment, the circuit management program 110 can include one or more components, such as add-ons, plug-ins, and agent programs, etc.include devices installed on one or more mobile units such as the Mobile Unit 102 to track movement sequences of artificial cells in a transplanted printed organic component and to monitor the performance and compatibility of the transplanted printed organic component in a patient.

[0020] According to one embodiment, the circuit management program 110 is a program for providing the ability to control the printing of multilayer circuits in different layers of printed biocells during three-dimensional bioprinting processes and furthermore to monitor movement sequences of the printed biocells in a transplanted organic component by applying external excitation pulses to the printed multilayer circuits. According to one embodiment, the circuit management program 110 provides the ability to print multilayer three-dimensional circuits in different layers of artificial cells of a printed organic component during a bioprinting process.According to one embodiment, the circuit management program 110 provides the capability to determine a sequence of operations using a plurality of multilayer printed circuits that can be configured to monitor the performance and biocompatibility of a transplanted organic component in a patient. According to another embodiment, the circuit management program 110 provides the capability to control self-powered printed circuits printed in different layers of artificial cells of a printed organic component, wherein, after implantation in a patient, the printed circuits generate electrical energy derived from the movement of artificial and natural tissues and signals for monitoring the performance and biocompatibility parameters of the printed organic component.According to one embodiment, the circuit management program 110 provides the ability to determine an intelligent combination of circuits to be printed sequentially within different layers of artificial cells of a printed organic component, at least partially based on the type of organic component, historical expected motion data, and a plurality of performance and compatibility parameters to be monitored, in order to acquire the plurality of performance and compatibility parameters for the printed organic component. According to another embodiment, the circuit management program 110 provides the ability to detect expected natural motion in the printed organic component and, accordingly, to determine an optimal location within the printed organic component for a printed circuit to extract electrical energy from the natural motion.According to one embodiment, the circuit management program 110 provides the ability to excite a printed circuit containing one or more piezoelectric chips from the outside and to supply the printed circuit with power based on natural movement in order to activate the printed circuit. According to another embodiment, the circuit management program 110 provides the ability to receive various signals from one or more printed circuits on a coupled mobile unit for the consistent and continuous monitoring of the printed organic component and furthermore for providing recommendations for printing circuits within a printed organic component.

[0021] According to one embodiment, the bioprinting unit 108 is a three-dimensional (3D) bioprinting unit that is connected to a server, such as the server computer 104, via a network, such as the network 106. According to another embodiment, the bioprinting unit 108 is an intelligent unit that is capable of being connected to a server computer, such as the server computer 104, or a mobile unit, such as the mobile unit 102, and of exchanging data with a program on a server, such as the circuit management program 110 on the server computer 104.According to one embodiment, the bioprinting unit 108 provides the capability to print one or more electronic circuits within one or more bioprinted organic components to capture real-time motion sequences of tissues. These sequences are used to monitor the performance and biocompatibility of the bioprinted organic components after transplantation into a patient. According to another embodiment, the bioprinting unit 108 is capable of printing organic components such as bone, skin, blood vessels, neurons, and internal organs using a printable bio-ink derived from cultured cells taken from a patient (i.e., human or animal). According to yet another embodiment, the bioprinting unit 108 is capable of printing the cells in a layered array using hydrogel as the support medium.According to one embodiment, the bioprinting unit 108 is capable of receiving instructions from a server computer such as the server computer 104, a mobile unit such as the mobile unit 102, and a circuit management program such as the circuit management program 110 to print multilayer electronic circuits within the cells of the organic component just printed using a three-dimensional bioprinting method. According to another embodiment, the bioprinting unit 108 is capable of receiving instructions from a server computer such as the server computer 104, a mobile unit such as the mobile unit 102, and a circuit management program such as the circuit management program 110 to print any number of electronic circuits at any number of specific locations within different layers of a printed organic component.According to one embodiment, the bioprinting unit 108 comprises several printheads for printing electronic circuits, biological ink, etc., and an integrated robotic mechanism for assembling the circuits, which include sensors, piezoelectric chips, and other parts of the electronic circuit.

[0022] Fig. Figure 2 shows a flowchart of work steps in a circuit management program such as the circuit management program 110 from Fig. 1 with reference number 200 for creating a sequence of work steps using multilayer printed circuits according to an embodiment of the present invention.

[0023] The circuit management program 110 identifies an organic component (202) to be printed. According to one embodiment, the circuit management program 110 identifies an organic component to be printed using an artificial intelligence (AI) system and requests user input to determine the organic component to be printed. For example, if a physician enters data such as patient data, a proposed surgical procedure, etc., into the circuit management program 110 via the user interface 112 of the mobile unit 102, the circuit management program 110 uses the AI ​​system to identify the organic component to be printed, at least partially, based on the entered data and historical data related to similar entered data.According to one embodiment, the circuit management program 110 can use the AI ​​system to query, for example, a proposed surgical procedure such as a leg transplant for an amputee patient in order to determine which left leg should be printed. In this example, the circuit management program 110 can further use the AI ​​system to determine the size, shape, color, etc., of the left leg.

[0024] The circuit management program 110 analyzes motion data for the organic component 204). According to one embodiment, the circuit management program 110 analyzes motion data for the organic component to be printed by retrieving the motion data for the organic component from a knowledge base. According to one embodiment, the circuit management program 110 accesses the knowledge base by querying the AI ​​system for historical data relating to a motion pattern for the organic component to be printed, for example, the natural (i.e., expected) range of motion for a healthy and functioning example of the organic component to be printed, how the muscular and skeletal system of the healthy and functioning example organic component performs the motion pattern, etc.According to one embodiment, the circuit management program 110 uses the historical data relating to the healthy and functioning example of the organic component to be printed, at least in part, based on the natural movement pattern of the organic component to be printed and the associated structures and systems, to identify a location, position, and orientation of the organic component that is comparatively static (i.e., to identify locations within the organic component that do not exhibit any movement), and furthermore to identify one or more specific locations of the organic component that exhibit the greatest possible movement relative to comparatively static locations.

[0025] The circuit management program 110 identifies one or more locations within the organic component where natural movement is expected (206). According to one embodiment, the circuit management program 110 identifies one or more locations within the organic component to be printed where natural movement is expected by analyzing various image data for an example of the organic component to be printed.According to one embodiment, the circuit management program 110 extracts from its knowledge base the various image data relating to a natural movement pattern of the exemplary organic component and further determines one or more specific locations of the organic component to be printed, from which the greatest possible movement is expected, at least partially based on the natural movement pattern of the exemplary organic component, associated structures and systems, scan results and images, etc. According to one embodiment, the circuit management program 110 determines, at least partially, depending on whether movement is expected for one or more specific locations, whether the one or more specific locations are suitable for printing the one or more electronic circuits.If one or more specific locations are capable of sufficient natural movement for the printed electronic circuits to detect actual movement of tissues, associated structures, and systems of the organic component after transplantation into a patient, the circuit management program designates the one or more specific locations as suitable locations. If one or more specific locations are not capable of sufficient natural movement for the printed electronic circuits to detect actual movement of tissues, associated structures, and systems after transplantation into a patient, the circuit management program designates the one or more specific locations as unsuitable locations.According to one embodiment, the circuit management program 110 identifies one or more specific locations within the organic component to be printed, provided that the one or more specific locations are suitable locations where the natural movement is sufficient to cause a piezoelectric chip located at the one or more specific locations to generate sufficient electrical current to power one or more interconnected electronic circuits throughout the organic component to be printed, which are located either at the one or more specific locations or at other comparatively static locations within the organic component.According to one embodiment, the circuit management program 110 determines one or more locations within the organic component to be printed, at least partially, based on areas within the organic component where the greatest possible movement is expected compared to other areas of the organic component. According to one embodiment, the circuit management program 110 is able to determine the one or more specific locations in a plurality of layers throughout the entire organic component to be printed. For example, if no natural tissue movement detectable by an electronic circuit is expected in a first layer of the organic component to be printed, the circuit management program 110 is able to determine the one or more locations in a second layer above the first layer, in a third layer above the second layer, and so on.

[0026] The circuit management program 110 determines a type of circuit to be printed at one or more locations within the organic component (208). According to one embodiment, the circuit management program 110 determines a type of circuit to be printed at one or more locations within the organic component, at least partially, based on the expected natural movement at one or more locations within the organic component and the tracking and performance values ​​desired for monitoring vital parameters, performance parameters, and the tolerability of the organic component in a patient.The circuit management program 110 can, for example, utilize an AI system to determine desired parameters for tracking and monitoring patient development, as well as to select parameters to be recorded, and, at least partially based on these parameters, determine the type of circuit to be printed at one or more locations within the organic component. According to one embodiment, the circuit management program 110 can determine the type of circuit to be printed as an electronic circuit using a circuit made of edible materials, such that the circuit is degraded and ingested by the patient after a certain period of time.According to one embodiment, the circuit management program 110 can identify a type of circuit to be printed as an electronic circuit using various sensors for measuring performance and compatibility values ​​such as pressure, temperature, mechanical stress, motion (e.g., velocity, dynamics, acceleration), or any other suitable parameters useful for tracking and monitoring the performance of the organic component to be printed after implantation. According to another embodiment, the circuit management program 110 can identify a type of circuit to be printed as an electronic circuit that is capable of being uniquely identifiable such that a mobile unit such as the mobile unit 102 can accurately monitor the outputs of each individual electronic circuit printed within the organic component.According to one embodiment, the circuit management program 110 can identify a type of circuit to be printed as an electronic circuit, which is connected to one or more additional electronic circuits and at least one piezoelectric chip located within the electronic circuit. For example, the circuit management program 110 is able to identify an electronic circuit connected to a piezoelectric chip, wherein the piezoelectric chip supplies power to the electronic circuit by converting physical movements of the organic component into electrical energy. According to one embodiment, the circuit management program 110 can identify a type of circuit to be printed as an electronic circuit using a protective capsule to protect the printed electronic circuit.According to one embodiment, the circuit management program 110 can determine the type of circuit to be printed as an electronic circuit using different thicknesses, at least partially, based on a position, orientation, and specific location within the various layers of the printed organic component. According to another embodiment, the circuit management program 110 can determine the type of circuit to be printed as an electronic circuit using an elastic material, so that the electronic circuit can remain active even in situations where excessive movement could cause damage to the electronic circuit.According to one embodiment, the circuit management program 110 determines a type of circuit to be printed as an electronic circuit that is capable of powering itself and of powering other circuits connected to it within the organic component. According to another embodiment, the circuit management program 110 can determine a type of circuit to be printed as an electronic circuit that is capable of monitoring and acquiring performance and compatibility data and transmitting this data to a coupled mobile unit such as the mobile unit 102.

[0027] The circuit management program 110 instructs a 3D bioprinting unit to print one or more circuits at one or more locations within the organic component (210). According to one embodiment, the circuit management program 110 instructs a 3D bioprinting unit, such as the bioprinting unit 108, to print one or more electronic circuits at one or more specific locations within the organic component. According to one embodiment, the circuit management program 110 is able to instruct a 3D bioprinting unit, such as the bioprinting unit 108, to print one or more electronic circuits at one or more specific locations within the organic component by sending instructions via a coupled mobile unit, such as the mobile unit 102, over a network, such as the network 106.According to one embodiment, the circuit management program 110 is able to send instructions containing the organic component, the one or more specific locations where the one or more electronic circuits are to be printed within the organic component, and the type of electronic circuits to be printed.

[0028] The condition after implantation of the organic component and the subsequent analysis of the movement sequences are described with reference to Fig. 4 explained in more detail.

[0029] Fig. Figure 3 is a structural diagram illustrating an arrangement of printed circuits within a biologically printed organic component reference 300 according to an embodiment of the present invention.

[0030] Diagram 300 shows layers 302, 304, 306, 308, and 310 of the organic component that make up the organic component 312. According to one embodiment, layer 302 of the organic component is the bottom layer (the first printed layer) of the organic component 312, and layer 310 of the organic component is the top layer (the last printed layer) of the organic component 312, with layers 304, 306, and 308 following sequentially upwards from layer 302 of the organic component to layer 310. Each layer 302, 304, 306, 308, and 310 contains the printed circuits 314, 316, 318, 320, and 322, respectively.Figure 300 illustrates how different types of printed circuits can be printed in different layers of a printed organic component, such as organic component 312, and at one or more specific locations where natural movement is expected. Figure 300 further illustrates how an external excitation pulse applied to the printed circuits 314, 316, 318, 320, and 322 is able to provide a signal response in a sequence of steps from layer 302 of the organic component, which contains the first printed circuit 314 in the sequence, to layer 310 of the organic component, which contains the fifth printed circuit 322 in the sequence, through the intervening layers 304, 306, and 308, and the corresponding printed circuits 304, 306, and 320 of organic component 312, respectively.

[0031] Fig. Figure 4 shows a flowchart of the work steps of a circuit management program such as the circuit management program 110 from Fig. 1 with reference number 400 for performing an analysis of movement sequences of an implanted printed organic component according to an embodiment of the present invention.

[0032] The circuit management program 110 determines a sequence of operations based on the one or more printed circuits within a printed organic component (402). According to one embodiment, the circuit management program 110 determines a sequence of operations based on the one or more printed circuits within a printed organic component by assigning the one or more printed circuits to a natural movement pattern expected by the printed organic component. If the one or more printed circuits are printed within different layers of the printed organic component, the circuit management program 110 determines a sequence of operations (e.g.,a movement sequence of the tissue), by which one or more printed electronic circuits are connected in series such that each of the one or more electronic circuits is activated in a sequence that replicates (i.e., mirrors) the natural movement sequence of the tissue in the printed organic component. According to one embodiment, the circuit management program 110 determines the sequence of operations based on historical data and machine learning regarding muscle movement and the flow of reflex arc signals, as well as the sequence of operations of the one or more electronic circuits to accurately capture the expected natural movement of the tissue in the printed organic component and the expected flow of reflex arc signals.According to one embodiment, the circuit management program 110 determines a sequence of operations by assigning a unique identifier to each of the one or more printed electronic circuits within the printed organic component and further uses these identifiers to activate the one or more printed circuits in the sequence of operations that replicate the natural sequence of movements expected by the printed organic component.

[0033] The circuit management program 110 activates the sequence of operations using external excitation pulses (404) applied to one or more printed circuits. According to one embodiment, the circuit management program 110 activates the sequence of operations of one or more printed electronic circuits by applying the external excitation pulses to the one or more circuits based on the unique identifiers assigned to each of the one or more printed electronic circuits.If, for example, one or more printed electronic circuits are characterized by a unique identifier that arranges each of the printed electronic circuits to precisely reflect the natural sequence of movements expected by the printed organic component, the circuit management program 110 activates the sequence of operations by applying an external excitation pulse to each of the printed electronic circuits in their corresponding order to replicate the natural sequence of movements expected by the printed organic component. According to one embodiment, the applied external excitation pulses can be electronic pulses, external reflex pulses, or any other suitable pulses for activating the sequence of operations.

[0034] The circuit management program 110 analyzes a signal response from one or more printed circuits in a sequence of operations (406). According to one embodiment, the circuit management program 110 analyzes the signal response from one or more printed circuits in a sequence of operations by receiving one or more signals generated by the one or more printed electronic circuits in a sequence of operations, wherein a measurable value of the signal strength of the one or more signals and the actually observed movement of the printed organic component indicates a status of the performance of the printed organic component as well as a status of the tolerability of the printed organic component in the patient.According to one embodiment, the circuit management program 110 can perform an analysis of the tissue movement sequences based on the applied external excitation pulses, a measurable response time for the signal response, and an expected signal response time for each of the one or more printed electronic circuits, wherein the measurable signal response time (e.g., for the actually observed movement of the printed organic component, the return of the signal, etc.) in relation to the applied external excitation pulses indicates a status of the performance of the printed organic component as well as a status of the tolerability of the printed organic component in the patient.For example, if the expected response time between a first circuit and a second circuit is 0.01 seconds and the actual signal response time between the first and second circuits is 0.1 seconds, the circuit management program 110 determines that the signal response time indicates an insufficient level of performance of the printed organic component. According to one embodiment, the circuit management program 110 is able to provide the signal response (i.e., the one or more signals and the associated response data) to a coupled mobile unit such as the mobile unit 102.According to one embodiment, the coupled mobile unit, such as mobile unit 102, is able to track and monitor a sequence of signals from the one or more printed electronic circuits within the printed organic component, and accordingly, the sequence of signals and the relative signal strengths of each of the one or more printed electronic circuits can be further analyzed to determine how the movement sequences of the tissue behave after implantation.When an augmented reality unit such as the mobile unit 102 is used, the circuit management program 110, according to one embodiment, can provide the signals and associated response data from each of the one or more printed electronic circuits within the printed organic component of the augmented reality unit and, based on a comparison with original signals from the one or more printed electronic circuits, generate a pictorial representation of a sequence of steps of the reflex action (i.e., a movement sequence) for printed organic component from different parts of the printed organic component in order to illustrate similarities and differences between the printed organic component and a healthy and functioning example of the printed organic component.In the present context, all retrieved, received, transmitted, or otherwise used data is subject to the user's express consent based on an option right. According to one embodiment, the circuit management program 110 requires a patient to provide express consent before any data is collected or used, based on an option right displayed on a mobile unit such as the mobile unit 102.For example, in the case of a patient undergoing transplantation of an organic component, and in addition to an implied or otherwise authorized patient-physician relationship, the circuit management program 110 ensures explicit patient consent for data use by prompting the patient on a mobile unit such as the mobile unit 102 to expressly consent, based on an option right, to the retrieval, receipt, collection, transmission, and other use of data relating to the procedure. According to one embodiment, the circuit management program 110 is able to send a notification (e.g., a warning) to a user's mobile unit such as the mobile unit 102 when data for which the use of which has been expressly authorized, based on an option right, is retrieved, received, collected, transmitted, or otherwise used by the circuit management program 110.

[0035] The circuit management program 110 generates one or more recommendations based on the analysis of the signal response (408). According to one embodiment, the circuit management program 110 generates one or more recommendations based on the analysis of the signal response by using an AI system to distinguish between functioning and defective neurons and muscles. According to one embodiment, the circuit management program 110 is able to detect a defective circuit, neuronal damage, or muscle damage based on the analysis of the signal response and accordingly generate a printing recommendation (e.g., a suggestion) on how the one or more printed circuits in the printed organic component should be reprinted to correct the defect.The circuit management program 110 can, for example, generate a recommendation to change the type of circuit, to change one or more specific locations for printing one or more electronic circuits, to change the number of one or more electronic circuits, etc., so that the progress can be tracked and corrections made over a period of time. According to one embodiment, the circuit management program 110 is able to send the one or more recommendations to a 3D bioprinting unit such as the bioprinting unit 108 in order to utilize the one or more recommendations during the reprinting of one or more electronic circuits.

[0036] Fig. Figure 5 shows a block diagram of components of a data processing system such as the server computer 104. Fig. 1 with reference number 500 according to an illustrative embodiment of the present invention. It should be obvious that Fig. Figure 5 merely illustrates one implementation and should not be interpreted as limiting the environments in which different embodiments can be realized. Many modifications can be made to the environment shown.

[0037] In the illustrative embodiment, the server computer 104 is shown in a distributed data processing environment 100 in the form of a general-purpose data processing unit such as the computer system 510. The components of the computer system can, but are not limited to, include one or more processors or processing units 514, a main memory 524, and a bus 516 that connects various system components, including the main memory 524, to the one or more processing units 514.

[0038] Bus 516 represents one or more different types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, and a processor or local bus, using one of a plurality of bus architectures. For example, such architectures include, but are not limited to, the ISA bus (Industry Standard Architecture), the MCA bus (Micro Channel Architecture), the EISA bus (Enhanced ISA), the VESA local bus (Video Electronics Standards Association), and the PCI bus (Peripheral Component Interconnect).

[0039] The Computer System 510 typically includes a variety of computer-readable media. Such media can be any available media accessible to the Computer System 510, including both volatile and non-volatile media, as well as interchangeable and non-interchangeable media.

[0040] The main memory 524 can comprise computer system-readable media in the form of volatile memory such as random access memory (RAM) 526 and / or a cache 528. The computer system 510 can further comprise other removable / non-removable, volatile / non-volatile storage media readable by a computer system. For example, a storage system 530 can further be provided for reading from and writing to a non-removable, non-volatile magnetic storage medium (not shown, commonly referred to as a "disk drive"). Not shown, a magnetic disk drive can be provided for reading from and writing to a removable non-volatile magnetic disk (e.g., a "floppy disk"), and an optical disk drive can be provided for reading from or writing to a removable non-volatile optical disk such as a CD-ROM, a DVD-ROM, or other optical media.In such cases, each drive can be connected to the bus 516 via one or more data media interfaces. It is further shown and described below that the main memory 524 can contain at least one computer program product with a set (e.g., at least one) of program modules configured to execute the functions of embodiments of the invention.

[0041] A program / utility 532 with one or more sets of program modules 534 can, for example, but is not limited to, be stored in main memory 524, as can an operating system, one or more application programs, other program modules, and program data. Each operating system, each of the one or more application programs, other program modules, and program data, or a combination thereof, can include an implementation of a network environment. The program modules 534 generally perform the functions and / or procedures of embodiments of the invention described herein. The computer system 510 can also exchange data with one or more external units 512, for example, a keyboard, a pointing unit, a screen 522, etc., or with one or more units that enable a user to interact with the computer system 510 and any other units (e.g., network cards, modems, etc.).) enable the computer system 510 to exchange data with one or more other data processing units. Such data transfer can occur via one or more input / output (I / O) interfaces 520. Furthermore, the computer system 510 can exchange data with one or more networks, for example, via a network adapter 518 with a local area network (LAN), a wide area network (WAN), and / or a public network (e.g., the Internet). The network adapter 518 shown exchanges data with other components of the computer system 510 via the bus 516. It should be clear that, although not shown, other hardware and software components such as microcode, unit drivers, redundant processing units, external disk arrays, RAID systems, tape drives, and storage systems for data archiving can also be used in conjunction with the computer system 510.

[0042] The present invention may be a system, a method, and / or a computer program product. The computer program product may comprise a computer-readable storage medium (or media) containing computer-readable program instructions to induce a processor to execute aspects of the present invention.

[0043] A computer-readable storage medium can be a physical unit capable of retaining and storing instructions for use by a system to execute instructions. For example, a computer-readable storage medium can be an electronic storage unit, a magnetic storage unit, an optical storage unit, an electromagnetic storage unit, a semiconductor storage unit, or any suitable combination thereof, without limitation. A non-exhaustive list of more specific examples of computer-readable storage media includes the following: a removable computer disk, a hard disk, random access memory (RAM), read-only memory (ROM), and erasable programmable read-only memory (EPROM).Flash memory), static random-access memory (SRAM), removable compact storage disk-read-only memory (CD-ROM), a DVD (digital versatile disc), a USB flash drive, a floppy disk, a mechanically coded unit such as punched cards or raised structures in a groove on which instructions are stored, and any suitable combination thereof. A computer-readable storage medium shall not, in its use herein, be understood as volatile signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through a waveguide or other transmission medium (e.g., light pulses traveling through an optical fiber cable), or electrical signals transmitted by a wire.

[0044] The computer-readable program instructions described herein can be downloaded from a computer-readable storage medium to individual data processing units or, via a network such as the internet, a local area network, a wide area network, and / or a wireless network, to an external computer or external storage device. The network may include copper transmission cables, fiber optic transmission lines, wireless transmission, routing computers, firewalls, switching units, gateway computers, and / or edge servers. A network adapter card or network interface in each data processing unit receives computer-readable program instructions from the network and forwards them for storage on a computer-readable storage medium within the respective data processing unit.

[0045] Computer-readable program instructions for executing the steps of the present invention can be assembly instructions, ISA (Instruction Set Architecture) instructions, machine instructions, machine-dependent instructions, microcode, firmware instructions, state-setting data, or either source code or object code written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Smalltalk, C++, etc., as well as conventional procedural programming languages ​​such as C or similar languages. The computer-readable program instructions can be executed entirely on the user's computer, partially on the user's computer, as a standalone software package, partially on the user's computer and partially on a remote computer, or entirely on the remote computer or server.In the latter case, the remotely located computer can be connected to the user's computer via any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection can be established with an external computer (for example, via the internet using an internet service provider). In some embodiments, electronic circuits, including, for example, programmable logic circuits, field-programmable gate arrays (FPGAs), or programmable logic arrays (PLAs), can execute the computer-readable program instructions by using state information from the computer-readable program instructions to personalize the electronic circuits to perform aspects of the present invention.

[0046] Aspects of the present invention are described herein with reference to flowcharts and / or block diagrams or diagrams of methods, devices (systems), and computer program products according to embodiments of the invention. It is pointed out that each block of the flowcharts and / or block diagrams or diagrams, as well as combinations of blocks in the flowcharts and / or block diagrams or diagrams, can be executed by means of computer-readable program instructions.

[0047] These computer-readable program instructions can be provided to a processor of a general-purpose computer, a specialized computer, or another programmable data processing device to create a machine, such that the instructions executed via the processor of the computer or other programmable data processing device generate a means of implementing the functions / steps specified in the block(s) of the flowcharts and / or block diagrams or charts.These computer-readable program instructions may also be stored on a computer-readable storage medium capable of controlling a computer, programmable data processing device, and / or other units to function in a particular manner, such that the computer-readable storage medium on which instructions are stored comprises a manufactured product, including instructions that implement aspects of the function / step specified in the block(s) of the flowchart and / or block diagrams or charts.

[0048] The computer-readable program instructions can also be loaded onto a computer, other programmable data processing device or other unit to cause the execution of a series of process steps on the computer or other programmable device or other unit in order to generate a process executed on a computer, such that the instructions executed on the computer, other programmable device or other unit implement the functions / steps specified in the block(s) of the flowcharts and / or block diagrams or charts.

[0049] The flowcharts and block diagrams or charts in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of the present invention. In this context, each block in the flowcharts or block diagrams or charts can represent a module, segment, or part of instructions comprising one or more executable instructions for performing the specified logical function(s). In some alternative embodiments, the functions specified in the block may occur in a different order than shown in the figures. For example, two blocks shown consecutively may in reality be executed essentially simultaneously, or the blocks may sometimes be executed in reverse order depending on the corresponding functionality.It should also be noted that each block of the block diagrams or charts and / or flowcharts, as well as combinations of blocks in the block diagrams or charts and / or flowcharts, can be implemented by special hardware-based systems that perform the specified functions or steps, or execute combinations of special hardware and computer instructions.

[0050] The descriptions of the various embodiments of the present invention are provided for illustrative purposes only and do not claim to be exhaustive or limited to the disclosed embodiments. Many modifications and variants will likely be obvious to those skilled in the art without altering the scope of protection and the essential content of the invention. The terms used herein have been chosen to explain the fundamental concepts of the invention, its practical application, or its technical improvement over commercially available technologies as clearly as possible, and to enable other skilled individuals to understand the embodiments disclosed herein.

[0051] The terms used herein serve only to describe individual embodiments and are not intended to limit the invention. It should be clear that all terms used herein have been chosen for convenience only and that the invention is therefore not intended to be limited exclusively to specific functions designated and / or included by such terms. Furthermore, the singular forms of "ein," "eine," and "der," "die," "das" are intended to include the plural forms as well, unless expressly indicated otherwise in the context.

Claims

[1] Method comprising: Determining a sequence of tissue movements by one or more computer processors (514) based at least in part on one or more printed circuits within a printed organic component; activating the sequence of tissue movements by the one or more computer processors (514) by applying external excitation pulses to the one or more printed circuits (314-322); analyzing a signal response from the one or more printed circuits by the one or more computer processors (514) in response to activating the sequence of tissue movements; and Generating one or more pressure recommendations by the one or more computer processors (514) based at least in part on the analysis of the signal response. [2] The method of claim 1, wherein the sequence of tissue movements is a sequence of movements that connects the one or more printed circuits (314-322) in series based at least in part on a unique identifier for each of the one or more printed circuits (314-322) such that each of the one or more printed circuits (314-322) activated in the sequence of tissue movements replicates a natural movement pattern expected of the printed organic component. [3] The method of claim 1, wherein determining the sequence of tissue movements further comprises: Determining the sequence of tissue movements by the one or more computer processors (514) based at least in part on historical data relating to the sequence of muscle movements and the flow of reflex arc signals. [4] The method of claim 1, further comprising: Assigning a unique identifier by the one or more computer processors (514) to each of the one or more printed circuits (314-322) according to a natural movement pattern expected of the printed organic component. [5] The method of claim 1, wherein analyzing the signal response further comprises: Receiving the signal response from the one or more printed circuits (314-322) by the one or more computer processors (514), the signal response comprising one or more signals generated by each of the one or more printed circuits as a result of tissue movements, wherein a measurable value of the signal strength of the one or more signals and an observed movement of the printed organic component indicate a level of performance for the printed organic component and a level of compatibility for the printed organic component. [6] The method of claim 1, wherein analyzing the signal response further comprises: Performing an analysis of movement sequences by the one or more computer processors (514) based at least in part on applied external pulses, a measurable response time for the signal response, and an expected signal response time for each of the one or more printed circuits (314-322), wherein the measurable signal response time, compared to the expected signal response time following the applied external pulses, indicates a level of performance for the printed organic component and a level of compatibility for the printed organic component. [7] The method of claim 1, further comprising: Generating, by the one or more computer processors (514) on an augmented reality device, a pictorial representation of a reflex action for the printed organic component based at least in part on the analysis of movement sequences, the pictorial representation including similarities and differences between the printed organic component and a healthy example of the printed organic component. [8] The method of claim 1, wherein generating the one or more printing recommendations further comprises: detecting a faulty circuit by the one or more computer processors (514) based at least in part on an analysis of the signal response; and wherein the one or more printing recommendations suggest how the one or more printed circuits in the printed organic component should be reprinted to correct the faulty circuit. [9] Computer program product comprising: one or more computer-readable storage media (500) and program instructions (534) stored on the one or more computer-readable storage media, the stored program instructions (534) for execution by the one or more computers (500) causing the one or more computers (500) to perform a method according to any one of claims 1 to 8. [10] A computer system (104) comprising: one or more computer processors (514); one or more computer-readable storage media (104); and program instructions (534) stored on the at least one or more storage media readable by the one or more computers (104) for execution by at least one of the one or more computer processors (514), the stored program instructions (534) comprising: Program instructions for determining a sequence of tissue movements based at least in part on one or more printed circuits (314-322) within a printed organic component; Program instructions for activating the sequence of tissue movements using external stimuli applied to the one or more printed circuits; Program instructions for analyzing a signal response from the one or more printed circuits (314-322) in response to activating the sequence of tissue movements; and Program instructions for generating one or more pressure recommendations based at least in part on the analysis of the signal response. [11] The computer system of claim 10, wherein the sequence of tissue movements is a sequence of movements that connects the one or more printed circuits (314-322) in series based at least in part on a unique identifier for each of the one or more printed circuits (314-322) such that each of the one or more printed circuits (314-322) in the sequence of tissue movements replicates a natural movement pattern expected of the printed organic component. [12] The computer system of claim 10, wherein the stored program instructions further comprise: Program instructions for assigning a unique identifier to each of the one or more printed circuits (314-322) according to a natural movement pattern expected by the printed organic component. [13] The computer system of claim 10w, wherein the program instructions for analyzing the signal response further comprise: Program instructions for receiving the signal response from the one or more printed circuits (314-322), the signal response including one or more signals generated by each of the one or more printed circuits in response to tissue movement, wherein a measurable value of the strength of the one or more signals and an observed movement of the printed organic component indicate a level of performance for the printed organic component and a level of compatibility for the printed organic component. [14] The computer system of claim 10, wherein the program instructions for analyzing the signal response further comprise: Program instructions for analyzing movement sequences based at least in part on the applied external excitation pulses, a measurable response time for the signal response, and an expected signal response time for each of the one or more printed circuits (314-322), wherein the measurable signal response time relative to the expected signal response time after the applied external excitation pulses indicates a level of performance for the printed organic component and a level of compatibility for the printed organic component.

Images