Fluidics module and bioprocess system

Abstract

Fluidics module (2) for a bioprocess system (1, 1', 1"), comprising a fluid circuit (13), and for engagement with a system mounting bracket (11) of the bioprocess system (1, 1', 1"), wherein the fluidics module (2) comprises: at least one fluidic device (3) for fluidic interaction with the fluid circuit (13), at least one module-side mounting bracket (4) for mounting the at least one fluidic module (2) at at least one discrete position on the system mounting bracket (11) such that the fluidic device (3) communicates with the fluid circuit, wherein the module-side mounting bracket (4) comprises at least one module-side fastening means (6) for engaging with at least one corresponding system-side fastening means (5) of the system mounting bracket (11), wherein the module-side fastening means (6) comprises at least: (a) a receiving fastening means (6) for at least partially receiving the system-side fastening means, which comprises at least one insertion fastening means (5), and / or (b) an insertion fastener to be at least partially received by at least one receiving fastener of the system-side fastener.

Description

TECHNICAL FIELD

[0001] The present invention relates to a fluidics module, the use of the fluidics module, a bioprocess system and the use of the bioprocess module. BACKGROUND OF THE INVENTION

[0002] A bioprocess system may be a system configured to handle fluid streams in a bioprocess, wherein the system may include one or more fluidic modules configured to act on the fluid streams (e.g., modify or detect them). The system may be a chromatography system or another filtration system.

[0003] Existing bioprocess systems may be limited with regard to the positioning and / or handling of fluidic modules. For example, a location of a fluidic module in a bioprocess system may be dictated by the system in such a way that the locations of the one or more fluidic modules within the bioprocess system are poorly or possibly not optimized. A less favorable location of the fluidic module may be perceived as less comfortable for the user. Furthermore, a non-optimal or unsuitable location of a fluidic module within the bioprocess system may result in functional limitations.

[0004] There is a need and desire to improve bioprocess systems and fluidic modules with regard to the handling and positioning of fluidic modules. PRESENTATION OF THE INVENTION

[0005] The present invention solves the above problem and provides a fluidic module for a bioprocessing system having a fluid circuit and for engagement with a mounting bracket of the bioprocessing system, wherein the fluidic module comprises: at least one fluidic device for fluidic interaction with the fluid circuit and at least one module-side mounting bracket for mounting the at least one fluidic module at at least one discrete position on the mounting bracket such that the fluidic device communicates with the fluid circuit, wherein the module-side mounting bracket comprises at least one module-side fastening means for engagement with at least one corresponding (complementary) system-side fastening means.The module-side fastening means comprises at least one receiving fastening means for at least partially receiving the system-side fastening means, which comprises at least one insertion fastening means and / or at least one insertion fastening means which is at least partially received by at least one receiving fastening means of the system-side fastening means.

[0006] According to one embodiment of the disclosure, a module-side fastening means may comprise or be a receiving fastening means, and a system-side fastening means may comprise or be an inserting fastening means, which is the corresponding or complementary counterpart. Alternatively or additionally, according to one embodiment of the disclosure, a module-side fastening means may comprise or be an inserting fastening means, and a system-side fastening means may comprise or be a receiving fastening means. It is not excluded that both receiving fastening means and inserting fastening means are provided on each of the module-side fastening means and the system-side fastening means. This means that both alternative embodiments are combined in a single fluidics module or bioprocessing system.

[0007] One idea underlying the present invention could be summarized as providing fluidic modules that are detachably attachable to the mounting bracket (e.g., engageable with and disengageable from the mounting bracket) and thus movable relative to the mounting bracket of the bioprocess system. For example, the fluidic modules can be repositioned on the mounting bracket such that they can be positioned at different positions or attachment locations on the mounting bracket. If modules can be repositioned, this can allow for modular use of the module, which can increase the versatility and / or adaptability of a bioprocess system.

[0008] The module-side mounting bracket is configured to be mounted at discrete mounting positions (in particular, specific, predetermined mounting positions as opposed to continuous, arbitrary mounting positions) when the fluidics module is arranged or mounted on the system-side mounting bracket. The module-side mounting bracket may be configured to allow it to be arranged at least at discrete positions on the mounting bracket. Optionally, the module-side mounting bracket is configured to define discrete positions for receiving a mating fastener of the system-side mounting bracket. Here, it is assumed that the male fastener and the female fastener allow mounting or fastening at discrete positions.However, this does not preclude the module-side mounting bracket from additionally being configured to be continuously shifted or moved around the discrete mounting position on the system-side mounting bracket.

[0009] A fluidic module or a fluidic device is in flow communication with the fluid circuit and the fluid flow and / or can be considered as a fluidic module or a fluidic device.

[0010] The fluidic module comprises a fluidic device, for example, a valve, such as a pneumatic, electronic, or manual valve, in particular a standard pneumatic pinch valve or an electronic pinch valve. The fluidic device may be a flow meter or a sensor (for example, a pressure sensor) or a filter. The fluidic device is configured for at least one type of fluidic interaction or connection with the fluid circuit.

[0011] A fluidics module of the disclosure can be considered a combination of a backplate or mounting plate and a fluidics device. For example, a conventional fluidics device can be attached or secured to the module-side mounting bracket.

[0012] A backplate or mounting plate is an example of a mounting panel. The mounting panel represents a mounting bracket-side mounting fixture. The mounting panel can be configured at least partially as a plate. Other geometric shapes are also possible for the panel instead of rectangular outlines. The mounting panel is at least partially planar.

[0013] The fluidic device can be positioned to face the operator and away from the mounting panel when installed on the mounting bracket.

[0014] The mounting bracket of the bioprocess system is a system-side mounting bracket. It can include or be a mounting panel (e.g., a shadow board). It can be made of a sheet metal, such as stainless steel.

[0015] The module-side fastening means and the system-side fastening means are designed to provide a mechanical connection between the fluidics module and the mounting bracket, i.e., to mount the fluidics module to the mounting bracket. The fastening means may be referred to as connectors.

[0016] The male fastener and the female fastener can be considered as corresponding or complementary, inverted fasteners.

[0017] A receiving fastener may include or be an opening, a slot, a hole, or the like. It may be considered a fastener configured to receive the corresponding male fastener in such a way that it at least partially surrounds or incorporates the male fastener.

[0018] An introducer fastener may comprise or be a pin, a projection, a hook, or the like. It may have an enlarged distal end, such as an introducer fastener head, for example, a pin head. The introducer fastener is configured to be at least partially received by the corresponding (complementary) female fastener.

[0019] For each individual fluidic module, one or more female attachment means or one or more male attachment means may be provided. For example, the fluidic module may comprise two attachment means, wherein the second attachment means is a supplementary attachment means that is optionally identical to the first attachment means. For example, if the first attachment means is configured for circular engagement, an additional attachment point may be desired, which may be implemented by a second attachment means, as described below.

[0020] A certain amount of play between complementary female and male fasteners is not excluded. While no play may be desirable, it is also possible to achieve a sufficiently reliable and stable connection between female and male fasteners with play.

[0021] Optionally (if the module-side fastening means is a receiving fastening means), the receiving fastening means comprises an entry or insertion section configured for entry (and exit), i.e., engagement and release, of the corresponding insertion fastening means, and at least one engagement section configured for engagement with the corresponding insertion fastening means (for holding, fastening, securing), wherein the receiving fastening means is configured such that the insertion fastening means is movable between the entry section and the at least one engagement section, and the entry section is at least partially larger than the at least one engagement section.Optionally, alternatively or additionally (if the module-side fastening means is an insertion fastening means), the insertion fastening means is arranged to be movable between the entry section and the at least one engagement section.

[0022] The two different portions of the female fastener can help to establish a connection between the male fastener and the female fastener by means of the dedicated entry or insertion portion and to maintain the engagement between the male fastener and the female fastener by means of the dedicated engagement portion.

[0023] For example, the entry portion may be larger than the engagement portion such that, should the entry portion and the engagement portion be placed on top of each other, the entry portion extends at least partially beyond the engagement portion.

[0024] The entry portion and the one or more engagement portions may be a single and / or through-opening, a single and / or through-slot, or a single and / or through-hole (may be connected to form a single and / or through-opening, a single and / or through-slot, or a single and / or through-hole), that is, they may be a single, through-receiving fastener.

[0025] The entry portion and the one or more engagement portions may allow (sliding) movement of a corresponding male fastener relative to each other in a direction of movement of the male fastener and the female fastener relative to each other.

[0026] The receiving fastening means can be configured for a sliding movement of the corresponding insertion fastening means between the entry section and the one or more engagement sections, i.e., around the arrangement position of the fluidic module on the mounting field, namely between discrete positions and in particular relative to the discrete system-side position. Accordingly, it should not be ruled out that the module-side mounting bracket is additionally configured to be continuously shifted or moved around the discrete mounting position on the system-side mounting bracket.

[0027] Moving the female fastener and the male fastener relative to each other may allow movement of the male fastener within the female fastener, i.e., movement of the male fastener between the engagement portion and the entry portion of the female fastener. Accordingly, movement of the male fastener relative to the female fastener may include sliding movement relative to each other around the actual mounting location of the fluidic device.

[0028] Optionally, the fluidics module comprises at least two module-side fastening means, which particularly preferably have an identical orientation and represent a pair of module-side fastening means that are intended to be simultaneously engaged with corresponding system-side fastening means, which represent a corresponding pair of system-side fastening means. This can help increase the reliability, accuracy, and / or stability of the mechanical connection between the fluidics module and the system.

[0029] The two module-side fasteners form a pair of fasteners on the fluidics module. The pair of fasteners is configured for simultaneous and thus additional engagement with a corresponding pair of fasteners on the system-side mounting bracket. Such a supplementary fastener may be a second fastener, as described above.

[0030] The additional, second fastening means may run parallel to the first fastening means and / or be spaced apart from it. In other words, the first and second fastening means may run parallel to each other and / or be spaced apart from each other, for example, in the horizontal direction.

[0031] The fluidic device can be positioned between the first and second fastening means. In other words, the pair of fastening means can accommodate or at least partially enclose the fluidic device on the module-side mounting bracket.

[0032] The distance between fasteners forming a pair of fasteners may be approximately 50 to 100 mm. More preferably, the distance may be between 70 and 90 mm, most preferably approximately 80 mm. This may allow sufficient space for the fluidic device between the fasteners and facilitate comfortable handling by the operator.

[0033] Optionally, at least one of the receiving fastener and the insertion fastener comprises a stopper (holder) for holding the receiving fastener and the insertion fastener engaged relative to each other in a holding position of the stopper.

[0034] The stopper is configured to assume at least the holding position, in which the stopper stops the movement of the receiving fastening means and the insertion fastening means relative to one another. The stopper can press against the receiving fastening means and the insertion fastening means such that relative movement of the first and second fastening means is substantially prevented or at least avoided. Optionally, the play between the receiving fastening means and the insertion fastening means can be reduced or eliminated. This can help prevent movement of the fluidic module relative to the system-side mounting bracket. In particular, a tight fit or positive fit can be established between the receiving fastening means and the insertion fastening means by means of the stopper.

[0035] For example, one stopper may be provided for each corresponding male fastener or female fastener. Therefore, either the male fastener or the corresponding female fastener may include the stopper. The stopper may be embodied as a resilient pressure piece. The stopper may be configured to move relative to each other perpendicular to a direction of movement of the corresponding male fastener and female fastener.

[0036] In particular, the stopper can help prevent movement of the fluidic device during operation. This can be particularly helpful when the fluidic device is embodied as a sensor whose contact points must remain in contact so that the sensor can be properly connected to a transmitter.

[0037] Furthermore, the stopper is optionally configured to protrude into at least part of an opening in the receiving fastening means when in its holding position and to rest against the receiving fastening means. This configuration of the stopper may be preferred in terms of ease of handling and reliability.

[0038] Optionally, the fluidics module is configured so that the stopper is preloaded into the holding position and retractable into a retracted position to facilitate the entry of the male fastener into the female fastener and / or the exit of the male fastener from the female fastener. This can facilitate the simple implementation of an effective stopper. Furthermore, the stopper can optionally be a spring-loaded stopper.

[0039] Optionally, the module-side mounting bracket comprises a mounting panel that defines a surface facing away from the fluidics device, which is in planar contact with at least a portion of the system-side mounting bracket. Particularly preferably, the system-side mounting bracket is a mounting panel of the bioprocess system. The surfaces of the module (more precisely: the assembly-side mounting bracket) and the system-side mounting bracket are adjacent to each other and run parallel to each other. This can support convenient and safe handling of the fluidics module when arranging it on the system.

[0040] Optionally, the fluidic module is configured such that hoses of the fluid circuit are positioned at an angle, optionally substantially orthogonally, relative to a direction of movement in which the male fastening means and the female fastening means are movable relative to each other, before they are engaged, i.e. after the insertion of the male fastening means into the female fastening means, in particular into the insertion opening of the female fastening means.

[0041] The direction of movement can be parallel to gravity, i.e., vertical. This allows gravity to assist the relative movement of the male fastener and the female fastener, if desired. In this case, the tubes can extend essentially horizontally or can be slightly angled.

[0042] The fluidic module may include an at least partially cylindrical support (embodied as a cavity) for receiving a portion of the hoses.

[0043] Optionally, the receiving fastening means comprises at least two engagement portions which are optionally opposite one another relative to the entry portion, and / or wherein the receiving fastening means is configured such that the insertion fastening means is movable between the entry portion and the at least two alternative engagement portions, further optionally wherein the two engagement portions have a substantially identical geometry.

[0044] This may allow the position of the fluidics module on the system-side mounting bracket to be selectively readjusted, and in particular, may allow the system to accept different configurations depending on which engagement portion is engaged with the insertion fastener. This may allow specific configurations for suction and / or discharge purposes.

[0045] The female fastener may be configured for sliding movement of the male fastener from one engaging portion to the other or opposite engaging portion of the female fastener.

[0046] For example, the entry section may be located in the direction of gravity, i.e., the direction of movement, between the two engagement sections (i.e., the first and second engagement sections). However, the direction of movement may alternatively also be in other directions, for example, perpendicular to gravity.

[0047] These devices, based on two selective engagement portions of a (single) receiving fastener, can allow for inclination of the hoses. (Nevertheless, in this case, the hoses can still be considered essentially horizontal hoses.)

[0048] The first and second engagement portions may constitute an upper and a lower engagement portion. In the vertical direction, the upper end of the upper engagement portion and the lower end of the lower engagement portion may have a distance of approximately 30 to 40 mm.

[0049] The engagement between the female fastener and the male fastener can thus be established at two different (discrete or horizontal) positions if the first and second engagement portions are at different heights (different horizontal positions, i.e. different levels in the direction of movement).

[0050] For example, in an upper position of the fluidic module (i.e., during engagement with the insertion fastener via the lower engagement section), an upward fluid flow is generated to assist in complete aspiration (venting). Such a device can also be used during normal operation, i.e., while the bioprocess is taking place. In a lower position of the fluidic module (i.e., during engagement with the insertion fastener via the upper engagement section), a downward fluid flow is generated to reduce a non-recoverable fluid volume by means of evacuation.

[0051] The present disclosure further relates to the use of the fluidics module, wherein the use comprises mounting the fluidics module to the mounting bracket of the bioprocessing system in such a manner that the at least one system-side fastener and the at least one module-side fastener are engaged. Therefore, the use comprises establishing engagement between the one or more receiving fasteners and the one or more corresponding or complementary inserting fasteners.

[0052] The present disclosure also relates to a bioprocessing system defining a fluid circuit and comprising a mounting bracket and configured for selective engagement with at least one fluidic module at at least two discrete positions, the mounting bracket comprising: at least two system-side fasteners each configured for engagement with a module-side fastener, each system-side fastener comprising at least: a receiving fastener for at least partially receiving the module-side fastener, comprising at least one inserting fastener, and / or an inserting fastener to be at least partially received by at least one receiving fastener of the system-side fastener, wherein the at least two system-side fasteners are located at different levels (e.g., heights,diagonals) on the mounting bracket, and the mounting bracket is configured such that the at least one fluidic module can be selectively mounted on the mounting bracket in the same orientation at discrete positions on the different levels.

[0053] In some embodiments, the bioprocessing system may consist essentially of the mounting bracket. The mounting bracket may be referred to as a panel or array and is associated with the system side.

[0054] The system-side mounting bracket provides a common mounting field for mounting fluidic modules and filters and other entities that form the fluid circuit.

[0055] The bioprocess system can be a chromatography system or another type of filtration system.

[0056] The system-side fastening means are alternative or optional fastening means such that a module selectively engages one of the system-side fastening means. The system-side fastening means thus define predefined possible positions for a fluidics module, or more precisely, for the fluidics module's fastening means.

[0057] The at least two system-side fasteners may form a set or series of system-side fasteners, wherein one system-side fastener (or multiple system-side fasteners if a pair of fasteners are used simultaneously) is selected for engagement with the one or more counterpart module-side fasteners.

[0058] These alternative fastening means may be considered a plurality, series, or set of potential system-side fastening means, and the corresponding module-side fastening means may selectively engage one of the system-side fastening means in the series. First, second, or third (e.g., top, middle, and bottom) system-side fastening means may be provided in the series of system-side fastening means.

[0059] As explained above, the system-side fasteners on the mounting bracket are configured for discrete positions for the fluidic modules. However, the system-side fasteners can be movable around the discrete positions to optionally accommodate additional discrete positions around the discrete position of the system-side fastener.

[0060] A system-side fastener (of a series) may comprise more than one, for example, a pair of system-side fasteners for simultaneous engagement with corresponding module-side fasteners. This was described above for corresponding fluidic modules that have a pair of module-side fasteners.

[0061] Of course, more than one series of system-side fasteners can be provided on the mounting bracket. A further, different series of system-side fasteners can be provided for simultaneous engagement with another module-side fastener. Each series can be embodied as a fastener in a row or line.

[0062] The plane can refer to a horizontal plane (height, i.e. a vertical positioning) or a vertical plane (relative to the page) or other planes, such as a diagonal.

[0063] The system-side mounting bracket may include an array of system-side fasteners, such as a series of system-side fasteners at different levels. The arrays may also include a pair of system-side fasteners at the same level for simultaneous engagement with a portion of module-side fasteners.

[0064] For example, pairs of fasteners of the same series of the same level may be spaced apart by approximately 50 to 100 mm, as described above in connection with the complementary fluidics module.

[0065] Fasteners of the same series at different levels can be spaced by more than 50 mm, optionally regularly for the same series. For example, a distance (e.g., the vertical distance) for one series can be approximately 80 mm and for another series approximately 180 mm.

[0066] Optionally, the system further comprises at least one fluidic module of the disclosure, wherein the module-side fastening means of the fluidic module is configured to engage and / or engage with one of the system-side fastening means of the mounting bracket.

[0067] Optionally, the system further comprises a filter configured to filter fluid of the fluid circuit for flow communication with the fluid circuit, wherein the filter is optionally substantially cylindrical and has an axis extending substantially in the vertical direction.

[0068] Multiple filters can be provided, and these can optionally be arranged at different levels, especially heights. The multiple filters can have different sizes, for example, lengths.

[0069] The present disclosure also relates to the use of the bioprocessing system of the disclosure, the use comprising engaging at least one of the at least two system-side fasteners with a module-side fastener and mounting at least one module to the system-side mounting bracket for fluid communication with the fluid circuit of the bioprocessing system, wherein the one of the at least two system-side fasteners with which the module-side fastener of the module is engaged is closer to the filter than the other of the at least two system-side fasteners that is not engaged with the module-side fastener.

[0070] Depending on the filter size, suitable, "optimal" system-side fasteners can be selected from the series or set of system-side fasteners to reduce the length of the hoses connected to the filter. Thus, the filter (the filter size) determines the suitable, "optimal" system-side fastener (or its position) so that the fluidics module is positioned in the appropriate, "optimal" position. In other words, the system-side fastener can be selected from the set of system-side fasteners based on the filter size or length.

[0071] This can allow the fluidic device to be positioned at a convenient level (e.g., height) while avoiding unnecessary fluid hoses connecting the fluidic device and the fluidic circuit. This can allow for more ergonomic positions for the operator.

[0072] Compared to existing bioprocess systems, such as chromatography systems or other filtration systems, which have different module sizes, such as different filter sizes (the size of the filters differs in terms of their external dimensions), the bioprocess system allows the operator or user to choose a favorable (cheaper), convenient (more convenient), or suitable (more suitable) (ergonomic) location for the or each fluidic module. The system may be configured to allow the positions of the fluidic modules to be adjusted (for example, with regard to the size of the filter). The adjustment may be based on a desired fluid connection length (for example, tubing length) between a fluidic module or filter and another fluid or fluidic entity.For example, undesirably long fluid connections (hoses) can be made shorter if a fluidic module is located at a more preferred location within the bioprocess system. The system can be configured to selectively accommodate multiple sizes of fluidic modules or filters and / or different fluidic modules or filters.

[0073] According to the disclosure, fluidic modules may have or occupy more than one potential mounting location on the system-side mounting bracket (to which the module may be moved, so that the module may be considered movable).

[0074] A fluidic module can have several positions on the mounting field, whereby the position can be selected depending on the size of the fluidic module.

[0075] In existing systems, fluidic modules have only a single mounting location (and can therefore be considered static). Existing (e.g., automated) systems are only designed for relatively large filters. If smaller filters are used, the smaller size must be compensated for by extending the tubing that communicates with the filter and / or the fluidic module.

[0076] This can make it possible to avoid problems with smaller fluidic modules or devices, for example, because suitable mounting locations can be selected for smaller fluidic modules or devices. For example, air can be avoided under a smaller filter. The handling of or interaction with fluidic modules or devices can also be improved, as a user or operator can position a fluidic module in a mounting location that is more suitable or appropriate with regard to the overall system. For example, a higher mounting location for the fluidic module can be selected for a smaller fluidic module instead of a lower mounting location (which may be required for a larger fluidic module).

[0077] Advantages of such a system may include improved suction, less non-recoverable residue volume, greater user-friendliness (smaller manifolds), and / or greater sustainability (shorter hoses in fluid communication with the fluidic device).

[0078] The disclosure also relates to a magnetic fastening system, alternatively or in addition to the mechanical fastening system of the disclosure. In particular, a magnetic fastening system of the disclosure can be defined as follows: Fluidics module for a bioprocess system having a fluid circuit and for engaging with a system-side mounting bracket of the bioprocess system, wherein the fluidics module comprises: at least one fluidic device for fluidic interaction with the fluid circuit, at least one module-side mounting bracket for mounting the at least one fluidic module at at least one discrete position on the system-side mounting bracket such that the fluidic device communicates with the fluid circuit, wherein the module-side mounting bracket comprises at least one module-side fastener for engaging with at least one corresponding system-side fastener, wherein each of the module-side magnetic fastener and the magnetic system-side fastener is configured to magnetically interact with the other, i.e., is magnetizable. Optionally, at least one of the module-side magnetic fastener and the magnetic system-side fastener comprises a permanent magnet, wherein more preferably the other of the module-side magnetic fastener and the magnetic system-side fastener comprises a magnetizable material for magnetic interaction with the permanent magnet. Optionally, each of the module-side magnetic fastener and the system-side magnetic fastener comprises a permanent magnet of opposite polarity.

[0079] A corresponding bioprocess system can be defined as follows: The bioprocess system defines a fluid circuit and comprises a mounting bracket and is configured for selective engagement with at least one fluidic module at at least two discrete positions, wherein the mounting bracket comprises at least two system-side magnetic fasteners, each configured for engagement with a module-side magnetic fastener, wherein the at least two system-side magnetic fasteners are located at different heights or levels on the system-side mounting bracket, and the mounting bracket is configured such that the at least one fluidic module is selectively mountable on the mounting bracket in the same orientation at discrete positions on the different levels or heights. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1(a) to 1(c) schematically illustrate a front view of a bioprocessing system according to an embodiment of the disclosure, wherein fluidic modules of an embodiment of the disclosure are provided. Fig. 1(a) shows a first arrangement of the system with small filters, Fig. 1(b) shows a second arrangement with medium-sized filters, and Fig. Figure 1(c) shows a third arrangement with large filters. Fig. 2(a) to 2(c) schematically illustrate perspective views of a fluidics module of an embodiment of the disclosure mounted to a mounting panel of a bioprocessing system according to an embodiment of the disclosure. Fig. 3(a) to 3(d) show schematic enlarged views of the engagement between a fluidics module of an embodiment of the disclosure and a mounting field of a bioprocessing system according to an embodiment of the disclosure. Fig. 4 schematically shows a fluidics module of an embodiment of the disclosure and an assembly field of a bioprocess system according to an embodiment of the disclosure. Fig. 5(a) and Fig. 5(b) schematically show a first and a second device of a fluidic module of an embodiment of the disclosure and a mounting field of a bioprocess system according to an embodiment of the disclosure. Fig. Figure 5(a) shows a first device in which the fluid module is in the upper, i.e. suction, position. Fig. Figure 5(b) shows a second device in which the fluid module is in the lower, i.e. emptying, position. Fig. 6 schematically shows a fluidics module of another embodiment of the disclosure and a bioprocess system according to another embodiment of the disclosure. DETAILED DESCRIPTION

[0080] Fig. 1(a), Fig. 1(b), and Fig. 1(c) schematically shows a front view of a bioprocessing system 1, 1', 1" according to an embodiment of the disclosure, wherein filters 9, 9', 9" are provided. Two filters 9, 9', 9" are arranged in series on a mounting panel 11 so that serial filtration is possible. The filters 9, 9', 9" may, for example, correspond to (a) a 2" filter, (b) a 5" filter, and (c) a 10" filter.

[0081] Fig. Figure 1(a) shows a first arrangement of the system 1 with small filters 9 arranged on a field 11 extending in a vertical direction V. The filters 9 are therefore located relatively high up, almost in an upper half of the field 11. Fig. Figure 1(b) shows a second arrangement of the system 1' with medium-sized filters 9' that are larger than the filters 9. Fig. 1(c) shows a third arrangement of system 1" with large filters 9", which are larger than filters 9'. Only in system 1" with the large filters 9" is the entire surface of field 11 required for assembly purposes, in particular also the lower part of field 11. The smaller size of the filters 9 and 9' in systems 1 and 1', respectively, leads to a reduction in the size of the fluid circuit 13 at field 11, in particular to a reduction in the extension to the bottom or lower part of field 11.

[0082] This space-saving arrangement in systems 1 and 1' is achieved because the fluidic modules 2 have been arranged at selected "optimized" positions, for example, at higher positions on the same array 11. These possible positions for a module are discrete and are determined by the attachment locations of fastening means, here the insertion fastening means 5, on the array 11, since the fluidic modules 2 are to be engaged and thus held by the insertion fastening means 5. An insertion fastening means 5 can, if appropriate in terms of its position, be selected for engagement with the fluidic module 2, for example, depending on the size of the fluidic module 2 or other fluid entities, such as a filter 9, 9', 9".In this way, the operator or user can select an insertion fastener 5 located near the filter 9, 9', 9" to reduce the length of the tubes 8 connecting, for example, the filter 9, 9', 9" and the fluidic module 2.

[0083] For example, the plurality of insertion fasteners 5 on the panel 11 may be arranged in sets, such as a series. Each set may include fasteners 5 arranged in a row or line, for example, extending in the vertical direction. Therefore, the arrangement of the fasteners 5 on the mounting bracket 11 may include horizontal rows or lines and vertical columns, as shown in Fig. 1(a) to 1(c). For example, six insertion fasteners (distributed, for example, like a cube) can be provided per set.

[0084] As in Fig. 1, the system 1, 1', 1" is a bioprocess system, for example, a filtration system, defining a fluid circuit 13 and comprising a mounting field 11 as a system-side mounting fixture. The filters 9, 9', 9" may be chromatography columns. The filters 9, 9', 9" are configured for flow connection with the fluid circuit 13 and are configured to filter fluid of the fluid circuit 13. The filters 9, 9', 9" are substantially cylindrical and have an axis extending substantially along the vertical direction V.

[0085] The system 1, 1', 1" is designed for selective engagement with at least one fluidic module 2 at at least two discrete positions, i.e. insertion fastening means 5. As shown in Fig. 1, a plurality of system-side fasteners 5 are provided on the array 11, each fastener 5 being configured to engage the fluidic modules 2. In other words, each system-side male fastener 5 provides a discrete mounting location for the module. To select a system-side fastener 5 and connect to the module-side female fastener 6, the module is moved to the specific or discrete mounting location of the system-side fastener 6. Each system-side fastener 5 comprises at least one male fastener to be at least partially received by at least one female fastener 6 of a fluidic module 2.

[0086] Fig. 1 shows that system-side fastening means 5 are located at different heights on the system-side mounting bracket 11. Thus, the mounting bracket 11 is configured such that the at least one fluidic module 2 can be selectively mounted in the same orientation at discrete positions at different heights in the vertical direction V on the mounting bracket 11.

[0087] In each of Fig. 1(a) to 1(c), four fluidic modules 2 are provided, each module 2 being held by an insertion fastener 5 of the array 11. The systems 1, 1', 1" thus comprise not only the array 11, but also fluidic modules 2, filters 9, 9', and 9", respectively, and hoses 8.

[0088] In particular, in each of the systems 1, 1', 1", some of the system-side fastening means 5 are engaged with corresponding or complementary module-side fastening means 6 (not shown) of the fluidic module 2. By mounting the at least one fluidic module 2 on the mounting bracket 11 for flow connection to the fluid circuit 13 of the bioprocess system 1, 1', 1", the system-side fastening means 5 with which the module-side fastening means 6 is engaged is located closer to the filter 9, 9', 9" than the other system-side fastening means 5 that are not engaged with the module-side fastening means 6. In Fig. 1(a), (b) and (c) show the “other” system-side fastening means 5 that are not currently used for engagement with the module 2. The system-side fastening means 5 that are engaged with the fluidic module 2 are shown in Fig. 1(a), (b) and (c) are hidden behind module 2 and are therefore not visible.

[0089] For example, a pair of fasteners 5 of the same series at the same height may be spaced apart by approximately 50 to 100 mm (perpendicular to the vertical direction V). Fasteners of the same series at different heights (i.e., of a pair) may be spaced apart by more than 50 mm, optionally regularly, as viewed perpendicular to the vertical direction V. For example, for one series, such a distance (e.g., vertical distance in the vertical direction V) may be approximately 80 mm, and for another series, such a distance may be approximately 180 mm.

[0090] Fig. 2(a) to 2(c) schematically illustrate perspective views of a fluidics module 2 of an embodiment of the disclosure mounted on the mounting panel 11 (only partially shown). The fluidics module 2 includes a module-side mounting bracket 4 for mounting the fluidics module 2 at a discrete position on the system-side mounting bracket 11.

[0091] The fluidic module 2 comprises a fluidic device 3 for fluidic interaction with the fluid circuit 13, such as a valve, a sensor, or a flow meter. However, within the meaning of the present disclosure, the filters 9, 9', 9" can also be configured as fluidic devices 3. This means that the filters can have a module-side mounting bracket 4 and can be attached to the mounting bracket 11, as described for the fluidic modules 2 of the disclosure.

[0092] The module-side mounting bracket 4 here is essentially a plate that abuts the field 11 and is aligned with the field 11. More generally, the module-side mounting bracket 4 comprises a module panel that defines a surface facing away from the fluidic device 3 and that abuts planarly against at least a portion of the field 11.

[0093] The module-side mounting bracket 4 comprises the module-side fastening means 6, here a receiving fastening means, for engagement with a corresponding system-side insertion fastening means 5 of the field 11. In particular, in the embodiment of Fig. 2, the module-side mounting bracket 4 includes two module-side fasteners 6 (one of which is hidden behind the device 3 in the perspective view). Here, the fluidics module 2 comprises two module-side fasteners 6 that have an identical orientation. These two module-side fasteners 6 represent a pair of module-side fasteners 6 for simultaneous engagement with a corresponding system-side fastener 5 (a pair of corresponding system-side fasteners 5).

[0094] Thus, the mounting field 11 comprises mounting pins 5 for mounting the fluidic module 2 (more precisely: its mounting panel 4) on the mounting field 11.

[0095] In Fig. 2(a), the fluidic module 2 is not yet engaged with the mounting bracket 11. Each receiving fastener, here an opening 6, receives a corresponding insertion fastener, here a pin 5. In Fig. 2(b), contact is established between the module 2 and the field 11 by receiving the pin 5 through the opening 6. The user has hooked the mounting panel 4 of the fluidic module 2 through the opening 6 onto the pin 5 on the mounting panel 11. The mounting panel 4 of the fluidic module 2 is now in contact with the field 11. Then, the fluidic module 2 is pushed downwards so that the pin 5 moves into the smaller part of the opening 6, namely the engagement section 6b, as in connection with Fig. 3(c) and Fig. 3(d) below. In this way, a locked position of the fluid module 2 on the system 1 is achieved.

[0096] In Fig. 2(c), the fluidic module 2 was moved downwards in the direction of movement M so that the pin 5 is accommodated in an upper section of the opening 6. This will be explained below with reference to Fig. 3(c) and (d) below.

[0097] The fluidic device 3 is positioned between the first fastening means 6 and the second fastening means 6 of the module-side mounting bracket 4. In other words, the pair of fastening means 6 accommodates the fluidic device 3 on the module-side mounting bracket 4 between them.

[0098] A distance between fastening means 6 forming a pair of fastening means (i.e., on the same mounting bracket 4) may be approximately 50 to 100 mm perpendicular to the vertical direction V, i.e., perpendicular to the direction of movement M. Particularly preferably, a distance may be between 70 and 90 mm, and most preferably approximately 80 mm.

[0099] Fig. 3(a) to (d) show in greater detail that the or each female fastener 5 comprises a stopper 7 which holds the female fastener 6 in engagement with the male fastener or pin 5 when the stopper 7 is in a holding position. In particular, in the holding position, the stopper 7 projects into at least part of the opening 6 and abuts the male fastener 5. The stopper 7 is embodied as a type of bolt whose head comes into contact with the pin 5. The stopper 7 is biased into the holding position and is retractable to a retracted position (not shown) to facilitate the entry of the male fastener 5 into the female fastener 6 and / or the exit of the male fastener 5 from the female fastener 6. The stopper 7 may, for example, be spring-loaded.Thus, the fluidic module 2 remains locked in place due to the spring pressure piece of the stopper 7.

[0100] Fig. 3(c) and (d) show that each of the two female fasteners 6 comprises an entry portion 6a configured for the entry and exit of the corresponding male fastener 5, respectively, and an engagement portion 6b configured for engagement with the corresponding male fastener 5. In particular, each female fastener 6 is configured such that the male fastener 5 is movable or displaceable between the entry portion 6a and the engagement portion 6b, and the entry portion 6a is at least partially larger than the engagement portion 6b. The engagement portion 6b is elongated in the vertical direction, i.e., in a movement direction M. The movement direction M may extend in the vertical direction. As a result, gravity may affect engagement between the engagement portion 6b and the pin 5.The direction of movement M is a direction in which the male fastening means and the female fastening means are movable or displaceable relative to each other and / or in which the module moves between the insertion portion and the engagement portion of the female fastening means.

[0101] Fig. 4 schematically shows a fluidic module 2 and a mounting field 11 (in parts), wherein each of the openings 6 in the mounting panel 4 has two engagement sections 6b, 6c. The two engagement sections 6b, 6c are opposite each other relative to the inlet section 6a, i.e., on the opposite side of the inlet section 6a in the vertical movement direction M, so that the inlet section 6a is located between the two engagement sections 6b, 6c. The female fastener or opening 6 is configured such that the male fastener or pin 5 is movable or displaceable between the inlet section 6a and the at least two engagement sections 6b, 6c. The two engagement sections 6b, 6c have a substantially identical geometry, namely an elongated shape. The inlet section 6a has a circular shape.Thus, the fluidic module 2 can be configured to be flexible depending on the size or dimensions of the fluidic module 2 or other entities positioned on the field 11, such as a filter (in . Fig. 4 not shown) can be moved between three positions and mounted on a pin 5 at corresponding three locations of the field 11.

[0102] Fig. 5(a) and Fig. 5(b) schematically show a first and a second device of a fluidic module 2 on an assembly field 11 of a bioprocess system 1. Fig. 5(a) shows a first device in which the fluid module 2 is in the upper, i.e. suction, position. Fig. 5(b) shows a second device in which the fluid module 2 is in the lower, i.e. emptying, position.

[0103] In particular, the fluidics module 2 is configured such that the hose 8 of the fluid circuit 13 is angled (here, essentially orthogonally angled) relative to a direction of movement M in which the male fastening means 5 and the female fastening means 6 are movable relative to each other, namely the vertical direction. This results in the effect that the hose connectors 10a, 10b are located at different heights, i.e., vertical positions.

[0104] In the suction position according to the Fig. In the first device shown in Figure 5(a), the angle α indicates the difference between a theoretical and substantially horizontal extension of the hose 8 and the actual inclination of the hose 8 in the suction position. The angle α can be between approximately 1 and 10°. Essentially, the angle α represents a positive inclination in the direction of fluid flow. The upstream hose connector 10a is located lower than the downstream hose connector 10b. Therefore, the suction position can be defined by displacing the fluidic module 2 upwards so that the pins 6 move into the lower, smaller engagement portion 6a of the opening 6. Accordingly, the fluidic module 2 is in its upper position in the suction position. The suction position can promote more reliable venting of the hose 8 to reduce the likelihood of air residue.

[0105] In the emptying position according to the Fig. In the second device shown in Figure 5(b), the angle β indicates the difference between a theoretical and substantially horizontal extension of the hose 8 and the actual inclination of the hose 8 in the emptying position. The angle β can be between approximately 1 and 10°. Essentially, the angle β represents a negative inclination in the direction of fluid flow. The upstream hose connector 10a is located higher than the downstream hose connector 10b. The emptying position can be defined by displacing the fluidic module 2 downwards such that the pins 6 move into the upper, smaller engagement portion 6c of the opening 6. Accordingly, the fluidic module 2 is in its lower position in the emptying position.The drain position may assist in the discharge of water after the water wet integrity test prior to use to reduce product dilution, and may also, alternatively or additionally, facilitate the recovery of more product at the end of the bioprocess, for example, fluid between the two filters 9 or 9' or 9", as shown in . Fig. 1(a), Fig. 1(b) and 1(c) respectively.

[0106] In Fig. 5 shows a cylindrical support 12 for holding the hose 8. The support 12 accommodates the hose 8 and allows the hose 8 to be inclined relative to the horizontal. Furthermore, the support can help protect against pinching fingers.

[0107] Fig. 6 schematically shows a fluidics module 2 of another embodiment of the disclosure and a bioprocess system 1 according to another embodiment of the disclosure, which is described using the same reference numerals. Both embodiments, both the Fig. 1 to 5 as well as the first embodiment shown in Fig.6, can be combined with each other, for example, by providing both types of fastening means 5, 6 on the mounting field 11 and both corresponding types of fastening means 6, 5 on the module-side mounting bracket, wherein complementary fastening means can engage. The first and second embodiments differ with regard to the type of fastening means 5, 6, namely whether the female fastening means and the male fastening means are provided on the system-side mounting bracket 11 or the module-side mounting bracket 4. The description in connection with the first embodiment also applies to the second embodiment. List of reference symbols: 1, 1', 1" bioprocess system 2 Fluidics module 3 Fluidic device 4 module-side fastening material / mounting panel 5 module-side insertion fastener / pin 5a Insertion fastener head 6 Mounting fasteners / opening 6a Insertion section of the receiving fastening means 6b, 6c engagement section of the receiving fastening means 7 stoppers 8 hoses 9, 9', 9" filters 10a,10b hose connectors 11 system-side fastening means / mounting field 12 cylindrical support for hoses 13 Fluid circuit M Direction of movement V vertical direction

Claims

[1] Fluid module (2) for a bioprocess system (1, 1', 1"), comprising a fluid circuit (13), and for interlocking with a system mounting bracket (11) of the bioprocess system (1, 1', 1"), wherein the fluid module (2) comprises: at least one fluidic device (3) for fluidic interaction with the fluid circuit (13), at least one module-side mounting bracket (4) for mounting the at least one fluidics module (2) at at least one discrete position on the system mounting bracket (11) such that the fluidics device (3) communicates with the fluid circuit, wherein the module-side mounting bracket (4) comprises at least one module-side fastening element (6) for engagement with at least one corresponding system-side fastening element (5) of the system mounting bracket (11), wherein the module-side fastening element (6) comprises at least: (a) a receiving fastening means (6) for receiving at least part of the system-side fastening means comprising at least one insertion fastening means (5), and / or (b) an insertion fastener which is to be received at least partially by at least one receiving fastener of the system-side fastener. [2] Fluidic module (2) according to claim 1, wherein the receiving fastening means (6) comprises an inlet section (6a) configured for the entry or exit of the corresponding insertion fastening means (5), and at least one engagement section (6b, 6c) configured for engagement with the corresponding insertion fastening means (5), wherein the receiving fastening means (6) is configured such that the insertion fastening means (5) is movable between the inlet section (6a) and the at least one engagement section (6b, 6c), and the inlet section (6a) is at least partially larger than the at least one engagement section (6b, 6c). [3] Fluidic module (2) according to claim 1 or 2, wherein the fluidic module (2) comprises at least two module-side fastening means (6) which optionally have an identical orientation and constitute a pair of module-side fastening means (6) for simultaneous engagement with corresponding system-side fastening means (5). [4] Fluidic module (2) according to one of the preceding claims, wherein at least one of the receiving fastening means (6) and the insertion fastening means (5) comprises a stopper (7) to hold the receiving fastening means (6) and the insertion fastening means (5) in a holding position of the stopper (7) in engagement. [5] Fluidic module (2) according to claim 4, wherein the stopper (7) is configured to protrude into at least a part of an opening of the receiving fastening means (6) in the holding position and to bear against the insertion fastening means (5). [6] Fluidic module (2) according to claim 4 or 5, wherein the fluidic module (2) is configured such that the stopper (7) is biased into the holding position and can be retracted into a retracted position to facilitate the insertion of the insertion fastening means (5) into the receiving fastening means (6) and / or the exit of the insertion fastening means (5) from the receiving fastening means (6). [7] Fluidics module (2) according to one of the preceding claims, wherein the module-side mounting bracket (4) comprises a module panel which defines a surface extending away from the fluidics device (3) which is planar to at least a part of the field (11), optionally a mounting field of the bioprocess system (1, 1', 1"). [8] Fluidic module (2) according to one of the preceding claims, wherein the fluidic module (2) is arranged such that a hose (8) of the fluid circuit is positioned at an angle, substantially orthogonally, relative to a direction of movement (M) in which the insertion fastening means (5) and the receiving fastening means (6) are movable relative to each other, before they are engaged. [9] Fluidic module (2) according to any of the preceding claims, if dependent on claim 2, wherein the receiving fastening means (6) comprises at least two engagement sections (6b, 6c) which are optionally opposite each other relative to the inlet section (6a), and / or wherein the receiving fastening means (6) is arranged such that the insertion fastening means (5) is movable between the inlet section (6a) and the at least two engagement sections (6b, 6c), wherein further optionally the two engagement sections (6b, 6c) have a substantially identical geometry. [10] Use of the fluidics module (2) according to any one of the preceding claims 1 to 9, wherein the use comprises mounting the fluidics module (2) on the mounting bracket (11) of the bioprocess system (1, 1', 1") in such a way that the at least one system-side fastening means (5) and the at least one module-side fastening means (6) are engaged. [11] Bioprocess system (1, 1', 1"), which defines a fluid circuit and includes a mounting bracket (11) and is set up for selective intervention with at least one fluid module (2) at at least two discrete positions, wherein the mounting bracket (11) comprises: at least two system-side fastening means (5) each designed for engagement with a module-side fastening means (6), each system-side fastening means (5) comprising at least: (a) a receiving fastening device for receiving at least part of the module-side fastening device, comprising at least one insertion fastening device, and / or (b) an insertion fastener (5) which is to be received at least partially by at least one receiving fastener (6) of the system-side fastener, wherein the at least two system-side fastening means (5) are located on different levels on the mounting bracket (11) and the mounting bracket (11) is configured such that the at least one fluidic module (2) can be selectively mounted on the mounting bracket (11) in the same orientation at discrete positions on the different levels. [12] Bioprocess system according to claim 11, further comprising at least one fluidics module (2) according to any one of the preceding claims 1 to 9, wherein the module-side fastening means (6) of the fluidics module (2) is configured for and / or engagement with one of the system-side fastening means (5) of the mounting bracket (11). [13] Bioprocess system according to claim 11 or 12, further comprising at least one filter (9, 9', 9") designed for filtering fluid of the fluid circuit for a flow connection with the fluid circuit, wherein the filter (9, 9', 9") is optionally substantially cylindrical and has an axis extending substantially in the vertical direction. [14] Use of the bioprocess system (1, 1', 1") according to any one of the preceding claims 11 to 13, wherein the use comprises engaging at least one of the at least two system-side fastening means (5) with the module-side fastening means (6) and mounting at least one fluidics module (2) on the mounting bracket (11) for a flow connection with the fluid circuit of the bioprocess system (1, 1', 1"), wherein one of the at least two system-side fastening means (5) with which the module-side fastening means (6) of the fluidics module (2) is engaged is located closer to the filter (9, 9', 9") than the other of the at least two system-side fastening means (5) which is not engaged with the module-side fastening means (6).

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