Dental care products with native cellulose

Description

[0001] The invention is defined in the appended claims and relates to an oral and dental care and tooth cleaning agent in the form of a paste with an addition of fine-grained, water-insoluble cleaning agents.

[0002] Conventional oral and dental care products, as well as tooth cleaning products in paste form, also known as toothpastes, commonly contain ingredients that have a cleaning and abrasive effect on the teeth. These effects are quantitatively defined by a PCR value (cleaning; PCR = (Pellicle Cleaning Ratio)) and an RDA value (abrasion; RDA = Relative Dentin Abrasion). Thus, with each use, the teeth are not only cleaned, but also slightly abrasive the tooth enamel. Toothpastes typically contain cleaning agents (abrasives) in the form of silicate or silica gel particles. Due to their hardness and angular surface structure, these particles have a high abrasive value and attack the tooth enamel relatively severely, especially with very frequent dental care.

[0003] DE 10 2014 201 628 A1 discloses an oral and dental care and tooth cleaning agent in the form of a paste, the cleaning particles of which consist of chemically processed cellulose, preferably microcrystalline cellulose. The cleaning particles have a spherical, round shape and a smooth surface with a knobby structure. This is intended to enable effective yet gentle tooth cleaning, even in hard-to-reach areas.

[0004] The object of the present invention is to provide a significantly improved toothpaste of the type mentioned at the beginning.

[0005] The object is achieved by an oral and dental care and tooth cleaning agent in the form of a paste with an addition of fine-grained, water-insoluble cleaning agents as defined in claim 1. Accordingly, the invention is characterized in that the cleaning agents consist of pure native cellulose, which corresponds to an untreated, natural cellulose obtained from plant precursor material by means of a digestion process and which, in contrast to microcrystalline cellulose, is not subjected to any further subsequent chemical modification process, and are formed as short-fiber particles with an irregular surface and a surface-rough structure which has a multitude of elevations and depressions, and that the cleaning agents have an average particle size of 30 µm to 80 µm.Pure native cellulose is understood to be untreated, natural cellulose obtained from plant precursor material by means of pulping processes. Unlike microcrystalline cellulose (MCC), it is not subjected to any subsequent chemical modification process. In particular, the pure native cellulose has not been chemically treated with dilute acid under high temperatures (> 100°C), as is usual in the production of MCC, and / or subjected to carboxylation. The native cellulose used in the invention is of purely plant origin and has not been chemically processed. Therefore, the pure native cellulose is also referred to below as natural cellulose. The particles / cleaning bodies formed from the native cellulose have a spherical, short-fiber shape with an irregular surface. The average particle size is 30–80 µm, preferably approximately 50 µm.The inventors have recognized and proven through intensive laboratory tests that, compared to conventional toothpastes containing microcrystalline cellulose, the oral and dental care and tooth cleaning agent disclosed here, using purely native or natural cellulose, achieves significantly better cleaning performance while still exhibiting lower abrasion of tooth enamel. Thus, two essentially contradictory effects or goals are achieved: high cleaning performance and a low abrasion value (RDA value). The results of the laboratory tests are described in detail in the following description.

[0006] Preferred embodiments emerge from the subclaims: Accordingly, the particles of the cleaning agents are preferably spherical particles with a diameter of approximately 50 µm. The cleaning agents preferably consist of pure, white, and odorless cellulose particles. The proportion of cleaning agents in the paste is 10 to 20 wt.%, preferably 14 wt.%.

[0007] Furthermore, the use of an oral and dental care and tooth cleaning agent according to the invention for cleaning teeth, including teeth fitted with multi-band appliances, is disclosed. Likewise, the use of bodies made of pure native cellulose as cleaning bodies for cleaning teeth, in particular for cleaning teeth fitted with multi-band appliances.

[0008] The invention is based on the finding that the addition of fine-grained, water-insoluble cleaning agents made of natural cellulose in a paste for tooth cleaning and oral and dental care can free the teeth of harmful plaque, particularly in narrow interdental spaces and in areas below the gum line, while brushing, without damaging the tooth enamel, as shown, for example, by measurements of the RDA value (Radioactive Dentine Abrasion).

[0009] The invention is based in particular on the idea that the hardness of native cellulose obtained from natural plant fibers can be varied over a wide range and thus adjusted to a hardness suitable for cleaning agents in an oral and dental care and tooth cleaning agent, while protecting tooth enamel during use. Another advantage of cleaning agents made from pure native cellulose is that they are completely non-toxic and non-irritating.

[0010] In experiments, the inventor discovered that cleaning agents made of pure native cellulose do not swell when water and oil are added.

[0011] Unlike cleaning agents made of synthetic ethylene-vinyl acetate copolymer, the cleaning agents made of pure native cellulose in an oral and dental care and tooth cleaning agent according to the invention do not extract any active ingredients from the paste. Rather, the cleaning agents or particles made of pure native cellulose ensure that the active ingredients contained in the oral and dental care and tooth cleaning agent can reach the teeth, gums, and oral mucosa during brushing.

[0012] The invention is explained in more detail below, whereby the following description refers to the use of a toothpaste (tooth cream) which has the following formulation, whereby the sum of all weight components must not exceed 100%: 50 to 70 wt.% humectant, preferably about 55% by weight; 10 to 20 wt.% Cleaning bodies made of pure native cellulose, preferably 14% by weight, with a particle size of 30-80µm, preferably about 50µm; 25 to 40 wt.% Sweeteners, preferably sodium saccharin and / or sorbitol 1 to 3 wt.% Binding and thickening agents, preferably cellulose gum and / or xanthan gum 2 to 5 wt.% Foaming agents, preferably surfactants 2 to 5 wt.% Active ingredients 1 to 3 wt.% Flavoring agents 0.1 to 0.5 wt.% Fluoride

[0013] The toothpaste disclosed here is an oral and dental care and tooth cleaning agent in which the cleaning particles contained therein have an average particle diameter of approximately 50 µm. They have a substantially spherical shape with a smooth surface and an irregular knobby structure.

[0014] The toothpaste is also suitable for cleaning teeth fitted with multi-band appliances. These appliances, which are used to correct misaligned teeth, feature mechanical brackets (brackets) bonded to the teeth, to which wire loops can be attached and locked.

[0015] The toothpaste, which contains essentially spherical cleaning particles, is applied using a conventional brushing technique, such as the rotation method. The action of saliva and the thixotropic properties of the toothpaste cause the water-insoluble cleaning particles contained in the toothpaste to become mobile.

[0016] The cleaning elements, powered by the toothbrush's bristles, transmit pushing and rotating movements to neighboring cleaning elements. This allows the cleaning elements to reach areas that the bristles can't directly reach.

[0017] The cleaning effect of the cleaning agents in toothpaste lies in the fact that the rotating motion polishes the tooth surface. Furthermore, the cleaning agents penetrate directly into coarser dirt or deposits, increasing their surface area. This breaks up the deposits and increases their solubility in water, making them easier to remove.

[0018] In the enclosed Figures 1 and 2 The structure of the cleaning bodies or particles made of native cellulose is illustrated. Fig. 1 shows a microscopic image / photograph; the Fig. 2This is an alternative representation obtained through edge detection, which shows the shape of the particles even more clearly. The surface, which is not formed as a knobby structure, but rather as a spherical, short-fibered, and surface-rough structure of the cleaning particles with the numerous elevations and depressions within it, ensures that when brushing with toothpaste, the cleaning particles come into contact with the surface of the teeth even in narrow fissures, thus achieving a good cleaning effect there as well.

[0019] The use of the cleaning agents significantly reduces friction, providing additional force to move the cleaning agents along the teeth. The rolling action of the cleaning agents minimizes abrasion of the dentin during brushing. Despite the low abrasiveness of the oral, dental care, and tooth cleaning agent, the teeth are thoroughly cleaned, leaving them smooth as a tongue.

[0020] During investigations, the inventor found that the plaque-reducing cleaning effect of the toothpaste described above enables a particularly effective yet very gentle (low RDA value) cleaning effect.

[0021] Intensive laboratory tests have shown that the toothpaste according to the invention can achieve a cleaning effect of 84% and more, whereas conventional toothpastes with MCC and silica only achieve a cleaning effect of about 40% or less (see documentation below).

[0022] With regard to the abrasion value, the toothpaste according to the invention can achieve an RDA value of 8 and less, whereas conventional toothpastes with MCC and silica have a significantly higher RDA value of about 32 (see the following documentation).

[0023] The oral and dental care and tooth cleaning agent disclosed here in the form of a paste is biodegradable and also meets vegan and other food standards, such as the requirements for the Jewish Kosher certificate and the Islamic Halal certificate. Here is the documentation of the laboratory tests: A) Cleaning performance: Cleaning performance Experimental setup:

[0024] Preparation of a toothpaste formula with a total of 14% of various cleaning particles (water-based). Determination of the cleaning performance on the preserved third molar human enamel (in vitro) based on Stookey and Muhler (1968) 1< and Stookey et al. (1982) 2< Enamel sections were ground to a reduced grain size (1200 grain - 6 µm) for a uniform surface. Storage in black tea at 37 °C for 4 hours based on Addy and Moran (1995) 3< Suspension of 25 g toothpaste in 40 ml water. Use of the brush simulator ZM-3.8 (SD-Mechatronic, Germany), toothbrush Oral-B Indicator 35 medium soft (pressure 150 g, 1,000 strokes at 60 mm sec -1,< hub 1 cm), 4 measurements per sample 1 Stookey. G. and Muhler, J. (1968): Laboratory Studies Concerning the Enamel and Dentin Abrasion Properties of Common Dentifrice Polishing Agents. J.Dent. Res. 47(4): 524-532 . 2 Stookey, G., Burkhard, T., Schemehorn, B. (1982): In Vitro Removal of Stain with Dentifries. J.Dent. Res. 61(11): 1236-1239 . 3 Addy, M. and Moran, J. (1995): Mechanisms of stain formation on teeth, in particular associated with metal ions and antiseptics, Adv. Dent. Res. 9(4): 450-456 . Colorimetric measurements:

[0025] Photographic analysis of the samples before and after the dyeing process as well as after the cleaning process. Colorimetric measurements to determine L*a*b values ​​(spectrometer CM 3600A, Konica Minolta) before and after the dyeing process as well as after the cleaning process.

[0026] ΔE 1 : colorimetric distance between the sample surface treated with blasting powder and the colored sample surface Δ E 1 = Δ L 1 2 + Δ a 1 2 + Δ b 1 2 ΔL 1 = L after cleaning process - L after dyeing process Δa 1 = a after cleaning process - a after dyeing process Δb 1 = b after cleaning process - b after dyeing process

[0027] ΔE 2 : colorimetric distance between the original sample surface and the colored sample surface Δ E 2 = Δ L 2 2 + Δ a 2 2 + Δ b 2 2 ΔL 2 = original - L after dyeing Δa 2 = originally - a after dyeing process Δb 2 = original - b after dyeing

[0028] Cleaning performance % = Δ E 1 Δ E 2 ∗ 100

[0029] An evaluation of the cleaning performance is given in the Fig. 3 illustrated. Conclusion:

[0030] All test formulas, as well as two samples of well-known toothpaste brands, were tested according to the experimental setup described above. SENSOCEL ®< dental particles correspond to the cleaning effect of standard silica or PE particles. SENSOCEL ®< dental products offer very high cleaning effectiveness with very low abrasion. By using SENSOCEL dental particles, the optimal balance between RDA and cleaning performance can be achieved. SENSOCEL ®< dental particles ensure effective yet gentle cleaning.

[0031] Colorimetric measurements are carried out in the Fig. 4a and 4b illustrated. B) Regarding the abrasion value: Relative dentin abrasion (RDA) Experimental setup:

[0032] Preparation of a toothpaste formula with a total of 14% various cleaning particles (water-based). Determination of RDA (relative dentin abrasion) using preserved third molar human dentin (in vitro) based on DIN EN ISO 11609: 2010 (Appendix B). Dentin sections were ground with a reduced grain size (4000 grit - 6 µm) for any surface and fixed with a sample holder. Suspension / slurry of 25 g toothpaste in 40 mL water, renewal of the slurry after 30 min. Use of the ZM-3_8 brush sensing unit (SD-Mechatronic, Germany), Oral-B Indicator 35 medium toothbrush (pressure 150 g, 10,000 strokes at a 60 mm hub, 1 cm), 6 measurements per sample. Profilometric determination of dentin loss by profilometry. RDA = mittlerer Abrieb der getesteten Zahnpasta mittlerer Abrieb der getesteten Referenz ∗ 100 (It is based on the Fig. 5 referred) Conclusion

[0033] All test formulas, as well as two samples of well-known toothpaste brands, were tested according to the experimental setup described above. SENSOCEL ®< dental samples exhibit very low abrasion compared to standard silica abrasives and available toothpaste brands. SENSOCEL ®< dental o200 exhibits a slightly higher RDA value, which is still considered a low RDA value compared to commercially available toothpastes. The measured RDA values ​​for Sample 1 and Sample 2 correlate with the manufacturer's specifications (Sample 1: RDA 36, Sample 2: RDA 40). B) Regarding the abrasion value: Relative Dentin Abrasion (RDA) Experimental setup:

[0034] preparation of a toothpaste formula with in total 14% of different cleaning particles (water-based) determination of RDA (relative dentin abrasion) on retained third molar human dentin (in vitro) based on DIN EN ISO 11609: 2010 (Annex B)dentin sections were ground at decreased grit (4000 Grit - 6 µm) for an even surface and were fixed on sample holder slurry preparation of 25 g toothpaste in 40 mL water, renewal of slurry after 30 min use of brushing simulator ZM-3.8 (SD-Mechatronic, Germany), toothbrush Oral-B Indicator 35 medium (pressure 150 g, 10,000 strokes at 60 mm sec -1< , hub 1 cm), 6 measurements per sample determination of dentin loss by profilometry RDA = mean abrasion of the tested toothpaste mean abrasion of the tested reference ∗ 100 Conclusion

[0035] all test formulas es well as two market samples of well-known toothpaste brands have been tested according to the above described experimental set-up SENSOCEL ®< dental particles show a very low abrasion compared to Standard Silica abrasive and available toothpaste brands SENSOCEL ®< dental o200 shows a slightly higher RDA-value which is still considered as low RDA-value compared to commercially available toothpastes the RDA values measured for market sample 1 and market sample 2 correlate with the manufacturer specifications (market sample 1: RDA 36, market sample 2: RDA 40)

Claims

1. Oral and dental care and tooth cleaning means in the form of a paste with an addition of fine-grained, water-insoluble cleaning bodies, characterized in that the cleaning bodies consist of pure native cellulose which corresponds to an untreated, natural cellulose which is obtained from vegetable precursor material by means of a pulping process and which, in contrast to microcrystalline cellulose, is not subjected to any further subsequent chemical-modifying process, and which are in the form of short-fibered particles with an irregular surface and a surface-rough structure which has a large number of elevations and depressions, and in that the cleaning bodies have an average particle size of 30 µm to 80 µm.

2. Oral and dental care and tooth cleaning means according to claim 1, characterized in that the particles of the cleaning bodies are spherical particles which have a particle size of about 50 µm with respect to their diameter.

3. Oral and dental care and tooth cleaning means according to claim 1 or 2, characterized in that the cleaning bodies consist of pure, white and odourless cellulose particles.

4. Oral and dental care and dental cleaning means according to claim 1 or 2, characterized in that the proportion of cleaning agents in the paste is 10 to 20% by weight, preferably 14% by weight.

5. Oral and dental care and tooth cleaning means according to any one of claims 1 to 4 for use in cleaning teeth, including teeth provided with multiband appliances.

6. Body made of pure native cellulose for use as a cleaning body for cleaning teeth, in particular for cleaning teeth fitted with multi-band appliances.