Method for producing tumor-infiltrating lymphocytes and uses thereof in immunotherapy

DE602019069740T2Active Publication Date: 2025-05-07IOVANCE BIOTHERAPEUTICS INC
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Patent Information

Application Number
DE602019069740
Authority / Receiving Office
DE · DE
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-09-20
Filing Date
2019-11-04
Publication Date
2025-05-07
Estimated Expiration
2039-11-04

AI Technical Summary

Technical Problem

Current TIL manufacturing processes are limited by length, cost, sterility concerns, and the need for improved scalability and potency of TIL preparations for cancer treatment.

Method used

A novel TIL expansion process that includes antigen-presenting feeder cells from the initiation of expansion, reducing the overall time and enhancing the expansion process.

Benefits of technology

This process results in a substantial reduction in the time required for TIL expansion, improving the cost-effectiveness and scalability of TIL manufacturing while producing more potent anti-cancer TIL preparations.

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