Polysaccharide-based artificial eardrum patch

EP4529463A2Pending Publication Date: 2025-04-02YILDIZ TEKNIK UNIVSI +1
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Patent Information

Application Number
EP2023913335
Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-12-30
Filing Date
2023-12-28
Publication Date
2025-04-02

AI Technical Summary

Technical Problem

Current treatments for tympanic membrane perforations, such as myringoplasty or tympanoplasty, require invasive surgical procedures, are costly, and often result in incomplete regeneration and ethical/biosafety concerns, with grafts from patients not retaining the membrane effectively, especially in large perforations.

Method used

A polysaccharide-based artificial eardrum patch using a levan polymer, PCL polymer, and mesenchymal stem cells (MSCs) in a 3D bioprinted scaffold, with a coaxial electrospinning method for the first layer and a levan-alginate hydrogel in the second layer, to enhance cell proliferation, adhesion, and migration, aiming for outpatient treatment and improved membrane retention.

Benefits of technology

This approach promotes faster tissue regeneration, reduces the need for patient-derived tissue, and increases the success rate of membrane retention, offering a non-invasive, cost-effective alternative with enhanced bioactivity and reduced risks of contamination or chemical inhomogeneity.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to an application to increase the cell proliferation, adhesion and migration in the tissue scaffolds developed in the field of the tissue engineering, which is used in the coverage of the tympanic membrane perforations with the help of a levan polymer (1.1).
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